The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 6,950 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ABBVIE INC COM 00287Y109 85,720 800,000 SH Call DFND 1,2,3,4,5,6 800,000 0 0
AC IMMUNE SA SHS H00263105 5,170 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERON PHARMA INC COM 00434H108 179,116 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
ADC THERAPEUTICS SA SHS H0036K147 3,041 95,000 SH   DFND 1,2,3,4,5,6 95,000 0 0
ADICET BIO INC COM 007002108 1,817 129,335 SH   DFND 1,2,3,4,5,6 129,335 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 27,100 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 8,224 1,045,000 SH   DFND 1,2,3,4,5,6 1,045,000 0 0
AGENUS INC COM NEW 00847G705 21,942 6,900,000 SH   DFND 1,2,3,4,5,6 6,900,000 0 0
ALBIREO PHARMA INC COM 01345P106 26,257 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 46,546 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 46,546 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
ALLOVIR INC COM 019818103 89,310 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 103,976 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 25,994 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 7,472 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 25,860 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 7,885 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 57,725 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 23,090 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101 8,364 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
APTINYX INC COM 03836N103 8,657 2,502,035 SH   DFND 1,2,3,4,5,6 2,502,035 0 0
ARAVIVE INC COM 03890D108 7,396 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 88,227 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 54,964 2,800,000 SH   DFND 1,2,3,4,5,6 2,800,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 13,830 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,637 142,500 SH   DFND 1,2,3,4,5,6 142,500 0 0
AXCELLA HEALTH INC COM 05454B105 3,698 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 258,390 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 14,535 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,154 150,000 SH Call DFND 1,2,3,4,5,6 150,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 81,520 1,000,000 SH   DFND 1,2,3,4 1,000,000 0 0
BIO-TECHNE CORP COM 09073M104 19,053 60,000 SH   DFND 1,2,3,4,5,6 60,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 52,771 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102 21,333 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 62,030 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
BRUKER CORP COM 116794108 9,488 175,275 SH   DFND 1,2,3,4,5,6 175,275 0 0
CARDIFF ONCOLOGY INC COM 14147L108 16,191 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 7,008 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 450 79,600 SH   DFND 1,2,3,4,5,6 79,600 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 37,837 2,282,100 SH   DFND 1,2,3,4,5,6 2,282,100 0 0
CHEMOCENTRYX INC COM 16383L106 40,248 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
CHIASMA INC COM 16706W102 1,653 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 2,863 180,500 SH   DFND 1,2,3,4,5,6 180,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 449 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CONTRAFECT CORP COM NEW 212326300 5,050 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
CURIS INC COM NEW 231269200 14,781 1,804,729 SH   DFND 1,2,3,4,5,6 1,804,729 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 33 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 5,528 1,806,531 SH   DFND 1,2,3,4,5,6 1,806,531 0 0
CYTOKINETICS INC COM NEW 23282W605 10,390 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DANAHER CORPORATION COM 235851102 11,107 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 28,535 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 33,504 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 6,300 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
EVELO BIOSCIENCES INC COM 299734103 8,463 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
FATE THERAPEUTICS INC COM 31189P102 127,302 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
FIBROGEN INC COM 31572Q808 14,836 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 34,879 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 17,450 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 93,640 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
GENERATION BIO CO COM 37148K100 79,782 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 22,811 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
HARPOON THERAPEUTICS INC COM 41358P106 13,288 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
HOOKIPA PHARMA INC COM 43906K100 10,531 949,616 SH   DFND 1,2,3,4,5,6 949,616 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 1,835 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
IGM BIOSCIENCES INC COM 449585108 105,948 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
I MAB SPONSORED ADS 44975P103 34,184 725,000 SH   DFND 1,2,3,4,5,6 725,000 0 0
IMMUNIC INC COM 4525EP101 10,703 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 13,600 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 18,560 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
IQIYI INC SPONSORED ADS 46267X108 14,858 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,258 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 37,001 1,094,047 SH   DFND 1,2,3,4,5,6 1,094,047 0 0
KALEIDO BIOSCIENCES INC COM 483347100 4,555 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KE HLDGS INC SPONSORED ADS 482497104 61,540 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 4,973 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 39,367 1,317,954 SH   DFND 1,2,3,4,5,6 1,317,954 0 0
KRYSTAL BIOTECH INC COM 501147102 14,250 237,500 SH   DFND 1,2,3,4,5,6 237,500 0 0
KURA ONCOLOGY INC COM 50127T109 19,596 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 15,500 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 6,750 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 12,025 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 231,405 67,662,150 SH   DFND 1,2,3,4 67,662,150 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 3,660 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,006 760,000 SH   DFND 1,2,3,4,5,6 760,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 31,932 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
METACRINE INC COM 59101E103 7,270 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MIRATI THERAPEUTICS INC COM 60468T105 109,820 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MODERNA INC COM 60770K107 5,224 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
MORPHIC HLDG INC COM 61775R105 55,414 1,651,686 SH   DFND 1,2,3,4,5,6 1,651,686 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 16,500 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 25,142 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 12,525 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,518 351,500 SH   DFND 1,2,3,4,5,6 351,500 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 3,385 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
OVID THERAPEUTICS INC COM 690469101 5,775 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 41,265 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 5,024 1,196,218 SH   DFND 1,2,3,4,5,6 1,196,218 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 2,681 133,000 SH   DFND 1,2,3,4,5,6 133,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 16,624 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 19,551 570,000 SH   DFND 1,2,3,4,5,6 570,000 0 0
REPLIMUNE GROUP INC COM 76029N106 26,705 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,124 321,100 SH   DFND 1,2,3,4,5,6 321,100 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 28,682 3,778,913 SH   DFND 1,2,3,4,5,6 3,778,913 0 0
SAGE THERAPEUTICS INC COM 78667J108 34,604 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHLUMBERGER LTD COM 806857108 21,830 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 101,913 2,100,000 SH   DFND 1,2,3,4,5,6 2,100,000 0 0
SCHRODINGER INC COM 80810D103 63,142 797,445 SH   DFND 1,2,3,4,5,6 797,445 0 0
SEER INC COM CL A 81578P106 327,909 5,840,911 SH   DFND 1,2,3,4,5,6 5,840,911 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 1,895 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 13,635 4,500,000 SH   DFND 1,2,3,4,5,6 4,500,000 0 0
SERES THERAPEUTICS INC COM 81750R102 4,900 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
SIGILON THERAPEUTICS INC COM 82657L107 13,256 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 9,695 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 32,634 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 46,551 1,606,308 SH   DFND 1,2,3,4,5,6 1,606,308 0 0
STOKE THERAPEUTICS INC COM 86150R107 15,483 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SURFACE ONCOLOGY INC COM 86877M209 924 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 8,138 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 27,625 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 15,465 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
TG THERAPEUTICS INC COM 88322Q108 78,030 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 22,116 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 30,891 2,100,000 SH   DFND 1,2,3,4,5,6 2,100,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 16,865 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 42,648 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
UNIQURE NV SHS N90064101 25,291 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
WW INTL INC COM 98262P101 361,566 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 14,112 285,028 SH   DFND 1,2,3,4,5,6 285,028 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 3,696 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 71,390 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
ZYMEWORKS INC COM 98985W102 16,541 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0