The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc Class A CL A COM 88025U109 55,067 388,891 SH   DFND 1 388,891 0 0
10X Genomics Inc Class A CL A COM 88025U109 20,293 143,312 SH   DFND 2 113,876 0 29,436
10X Genomics Inc Class A CL A COM 88025U109 34,383 242,817 SH   DFND 3 168,549 0 74,268
1Life Healthcare COM 68269G107 19 432 SH   DFND 3 432 0 0
2U COM 90214J101 12 292 SH   DFND 3 292 0 0
8x8 Inc COM 282914100 88 2,565 SH   DFND 3 2,565 0 0
ACM Research COM 00108J109 17 208 SH   DFND 3 208 0 0
AJ Gallagher & Co COM 363576109 130,972 1,058,704 SH   DFND 1 1,058,704 0 0
AJ Gallagher & Co COM 363576109 457,438 3,697,664 SH   DFND 2 3,443,049 0 254,615
AJ Gallagher & Co COM 363576109 92,068 744,228 SH   DFND 3 331,606 0 412,622
AJ Gallagher & Co COM 363576109 304,534 2,461,680 SH   SOLE 0 2,286,914 0 174,766
Abiomed COM 003654100 316,306 975,652 SH   DFND 1 975,652 0 0
Abiomed COM 003654100 406,937 1,255,204 SH   DFND 2 1,164,777 0 90,427
Abiomed COM 003654100 89,947 277,444 SH   DFND 3 164,785 0 112,659
Abiomed COM 003654100 172,969 533,527 SH   SOLE 0 503,761 0 29,766
Acacia Communications Inc COM 00401C108 56 769 SH   DFND 3 769 0 0
Acadia Pharmaceuticals Inc COM 004225108 28 532 SH   DFND 3 532 0 0
Accelerate Diagnostics COM 00430H102 3 371 SH   DFND 3 371 0 0
Accenture 'A' COM G1151C101 12 47 SH   DFND 3 47 0 0
Acutus Medical COM 005111109 12 418 SH   DFND 3 418 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 27,849 5,166,864 SH   DFND 1 5,166,864 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 10,688 1,982,970 SH   DFND 2 714,325 0 1,268,645
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 4,165 772,784 SH   DFND 3 772,784 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 13,126 2,435,162 SH   SOLE 0 2,435,162 0 0
Adicet Bio Inc COM 007002108 1,313 93,449 SH   DFND 1 93,449 0 0
Adicet Bio Inc COM 007002108 1,239 88,177 SH   SOLE 0 88,177 0 0
Advanced Micro Devices Inc COM 007903107 48 526 SH   DFND 3 526 0 0
Aerovironment COM 008073108 30,460 350,517 SH   DFND 1 350,517 0 0
Aerovironment COM 008073108 21,822 251,120 SH   DFND 2 91,376 0 159,744
Aerovironment COM 008073108 8,326 95,816 SH   DFND 3 95,816 0 0
Aerovironment COM 008073108 19,167 220,567 SH   SOLE 0 220,567 0 0
Agios Pharmaceuticals Inc COM 00847X104 8 183 SH   DFND 3 183 0 0
Agora Inc ADR ADS 00851L103 10,495 265,288 SH   DFND 1 265,288 0 0
Agora Inc ADR ADS 00851L103 6,643 167,912 SH   SOLE 0 167,912 0 0
Albemarle Corp COM 012653101 92,656 628,091 SH   DFND 1 628,091 0 0
Albemarle Corp COM 012653101 271,268 1,838,858 SH   DFND 2 1,705,220 0 133,638
Albemarle Corp COM 012653101 55,555 376,596 SH   DFND 3 169,701 0 206,895
Albemarle Corp COM 012653101 199,537 1,352,611 SH   SOLE 0 1,264,070 0 88,541
Alector Inc COM 014442107 22 1,474 SH   DFND 1 1,474 0 0
Alector Inc COM 014442107 1,157 76,483 SH   DFND 2 76,483 0 0
Alector Inc COM 014442107 673 44,449 SH   DFND 3 44,449 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 524,906 2,255,428 SH   DFND 1 2,255,428 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 3,054,272 13,123,673 SH   DFND 2 6,687,215 0 6,436,458
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 300,994 1,293,318 SH   DFND 3 838,973 0 454,345
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 1,954,231 8,396,989 SH   SOLE 0 6,997,743 0 1,399,246
Align Technology Inc COM 016255101 15,682 29,346 SH   DFND 2 29,346 0 0
Alkermes Plc COM G01767905 3 155 SH   DFND 3 155 0 0
Allscripts Healthcare Solution COM 01988P108 10 704 SH   DFND 3 704 0 0
Alnylam Pharmaceuticals COM 02043Q107 303,844 2,337,799 SH   DFND 1 2,337,799 0 0
Alnylam Pharmaceuticals COM 02043Q107 474,131 3,648,005 SH   DFND 2 3,061,396 0 586,609
Alnylam Pharmaceuticals COM 02043Q107 120,001 923,300 SH   DFND 3 609,019 0 314,281
Alnylam Pharmaceuticals COM 02043Q107 288,965 2,223,318 SH   SOLE 0 2,121,630 0 101,688
Alphabet Inc Class A CAP STK CL A 02079K305 95,727 54,619 SH   DFND 1 54,619 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 98,689 56,309 SH   DFND 2 42,865 0 13,444
Alphabet Inc Class A CAP STK CL A 02079K305 50,313 28,707 SH   DFND 3 18,323 0 10,384
Alphabet Inc Class A CAP STK CL A 02079K305 136,271 77,752 SH   SOLE 0 77,752 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 636,542 363,348 SH   DFND 1 363,348 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,869,803 1,067,312 SH   DFND 2 729,763 0 337,549
Alphabet Inc Class C CAP STK CL C 02079K107 247,605 141,337 SH   DFND 3 78,070 0 63,267
Alphabet Inc Class C CAP STK CL C 02079K107 720,189 411,095 SH   SOLE 0 321,039 0 90,056
Alteryx Inc COM 02156B103 39 321 SH   DFND 3 321 0 0
Amazon.Com COM 023135106 1,329,251 408,130 SH   DFND 1 408,130 0 0
Amazon.Com COM 023135106 5,512,442 1,692,527 SH   DFND 2 1,104,010 0 588,517
Amazon.Com COM 023135106 457,618 140,506 SH   DFND 3 92,149 0 48,357
Amazon.Com COM 023135106 3,113,876 956,077 SH   SOLE 0 824,492 0 131,585
Ambarella SHS G037AX101 26,738 291,200 SH   DFND 1 291,200 0 0
Ambarella SHS G037AX101 12,612 137,355 SH   DFND 2 49,356 0 87,999
Ambarella SHS G037AX101 4,704 51,233 SH   DFND 3 51,233 0 0
Ambarella SHS G037AX101 8,962 97,605 SH   SOLE 0 97,605 0 0
Ameren COM 023608102 44,679 572,364 SH   DFND 1 572,364 0 0
Ameren COM 023608102 90 1,150 SH   DFND 2 1,150 0 0
Ameren COM 023608102 2,403 30,781 SH   DFND 3 30,781 0 0
American Electric Power COM 025537101 51,719 621,100 SH   DFND 1 621,100 0 0
American Electric Power COM 025537101 96 1,148 SH   DFND 2 1,148 0 0
American Electric Power COM 025537101 2,743 32,943 SH   DFND 3 32,943 0 0
American Superconductor Corp COM 030111207 15,230 650,300 SH   SOLE 0 650,300 0 0
American Well Corp Class A COM 03044L105 57 2,246 SH   DFND 1 2,246 0 0
American Well Corp Class A COM 03044L105 2,900 114,487 SH   DFND 2 114,487 0 0
American Well Corp Class A COM 03044L105 1,772 69,973 SH   DFND 3 69,973 0 0
Amicus Therapeutics Inc COM 03152W109 12 535 SH   DFND 3 535 0 0
Amneal Pharmaceuticals Inc COM 03168L105 2 517 SH   DFND 3 517 0 0
Analog Devices COM 032654105 24,096 163,105 SH   DFND 1 163,105 0 0
Analog Devices COM 032654105 882 5,973 SH   DFND 2 0 0 5,973
Analog Devices COM 032654105 82 556 SH   DFND 3 556 0 0
Analog Devices COM 032654105 24,509 165,902 SH   SOLE 0 165,902 0 0
Anaplan Inc Common COM 03272L108 21 296 SH   DFND 3 296 0 0
Anaplan Inc Common COM 03272L108 134,478 1,871,644 SH   SOLE 0 1,871,644 0 0
Annaly Capital Man. COM 035710409 63 7,446 SH   DFND 1 7,446 0 0
Anterix COM 03676C100 6 162 SH   DFND 3 162 0 0
Anthem Inc COM 036752103 157,882 491,705 SH   DFND 1 491,705 0 0
Anthem Inc COM 036752103 598,404 1,863,664 SH   DFND 2 1,732,612 0 131,052
Anthem Inc COM 036752103 121,898 379,638 SH   DFND 3 169,452 0 210,186
Anthem Inc COM 036752103 390,658 1,216,662 SH   SOLE 0 1,126,496 0 90,166
AppFolio COM 03783C100 47 262 SH   DFND 3 262 0 0
Appian Corp CL A 03782L101 395,179 2,438,020 SH   DFND 1 2,438,020 0 0
Appian Corp CL A 03782L101 397,463 2,452,111 SH   DFND 2 2,028,486 0 423,625
Appian Corp CL A 03782L101 41,073 253,398 SH   DFND 3 253,398 0 0
Appian Corp CL A 03782L101 161,907 998,873 SH   SOLE 0 998,873 0 0
Apple COM 037833100 26,422 199,125 SH   DFND 1 199,125 0 0
Apple COM 037833100 1,106 8,335 SH   DFND 2 0 0 8,335
Apple COM 037833100 90 680 SH   DFND 3 680 0 0
Apple COM 037833100 27,038 203,767 SH   SOLE 0 203,767 0 0
Applied Optoelectronics COM 03823U102 2 260 SH   DFND 3 260 0 0
Aptiv COM G6095L109 19 147 SH   DFND 3 147 0 0
Ares Capital Corp COM 04010L103 30,081 1,781,000 SH   DFND 1 1,781,000 0 0
Ares Capital Corp COM 04010L103 59 3,500 SH   DFND 2 3,500 0 0
Ares Capital Corp COM 04010L103 1,628 96,370 SH   DFND 3 96,370 0 0
Argan COM 04010E109 5 103 SH   DFND 3 103 0 0
Arista Networks COM 040413106 28 98 SH   DFND 3 98 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 95 568 SH   DFND 1 568 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 4,811 28,848 SH   DFND 2 28,848 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 2,959 17,739 SH   DFND 3 17,739 0 0
Atlassian Corp Plc CL A G06242104 133,651 571,476 SH   DFND 1 571,476 0 0
Atlassian Corp Plc CL A G06242104 1,019,693 4,360,086 SH   DFND 2 1,363,507 0 2,996,579
Atlassian Corp Plc CL A G06242104 86,478 369,769 SH   DFND 3 288,647 0 81,122
Atlassian Corp Plc CL A G06242104 298,294 1,275,471 SH   SOLE 0 614,494 0 660,977
Atrion COM 049904105 6 9 SH   DFND 3 9 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 36,668 368,082 SH   DFND 1 368,082 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 137,976 1,385,021 SH   DFND 2 1,287,125 0 97,896
Autohome Inc - ADR SP ADR RP CL A 05278C107 28,173 282,802 SH   DFND 3 126,121 0 156,681
Autohome Inc - ADR SP ADR RP CL A 05278C107 94,827 951,884 SH   SOLE 0 881,287 0 70,597
Avangrid COM 05351W103 64,352 1,415,875 SH   DFND 1 1,415,875 0 0
Avangrid COM 05351W103 123 2,701 SH   DFND 2 2,701 0 0
Avangrid COM 05351W103 2,987 65,728 SH   DFND 3 65,728 0 0
Avery Dennison Corporation COM 053611109 17 109 SH   DFND 3 109 0 0
Axogen Inc COM 05463X106 7,874 439,900 SH   DFND 1 439,900 0 0
Axogen Inc COM 05463X106 7,226 403,677 SH   DFND 2 149,102 0 254,575
Axogen Inc COM 05463X106 2,659 148,575 SH   DFND 3 148,575 0 0
Axogen Inc COM 05463X106 3,036 169,600 SH   SOLE 0 169,600 0 0
Axon Enterprise Inc COM 05464C101 99,625 813,067 SH   DFND 1 813,067 0 0
Axon Enterprise Inc COM 05464C101 226,896 1,851,760 SH   DFND 2 1,598,494 0 253,266
Axon Enterprise Inc COM 05464C101 53,191 434,105 SH   DFND 3 241,638 0 192,467
Axon Enterprise Inc COM 05464C101 150,757 1,230,367 SH   SOLE 0 1,145,997 0 84,370
Axonics Modulation Technologies COM 05465P101 12 249 SH   DFND 3 249 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 12,781 59,105 SH   DFND 1 59,105 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 797,531 3,688,176 SH   DFND 2 3,379,722 0 308,454
Baidu.com Sponsored ADR SPON ADR REP A 056752108 40,772 188,549 SH   DFND 3 19,225 0 169,324
Baidu.com Sponsored ADR SPON ADR REP A 056752108 1,917 8,867 SH   DFND 4 8,867 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 719 3,325 SH   SOLE 0 3,325 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 21,826 4,149,462 SH   DFND 1 4,149,462 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 148,100 28,155,813 SH   DFND 2 14,440,247 0 13,715,566
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 4,484 852,446 SH   DFND 3 852,446 0 0
Bandwidth COM 05988J103 23 150 SH   DFND 3 150 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 20,349 592,408 SH   DFND 1 592,408 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 15,669 456,168 SH   DFND 2 165,973 0 290,195
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 5,889 171,432 SH   DFND 3 171,432 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 10,102 294,100 SH   SOLE 0 294,100 0 0
Barrick Gold Corp COM 067901108 137 6,005 SH   DFND 2 6,005 0 0
Beam Therapeutics COM 07373V105 40 495 SH   DFND 3 495 0 0
BeiGene Ltd SPONSORED ADR 07725L102 108,864 421,315 SH   DFND 1 421,315 0 0
BeiGene Ltd SPONSORED ADR 07725L102 733,418 2,838,416 SH   DFND 2 930,380 0 1,908,036
BeiGene Ltd SPONSORED ADR 07725L102 57,822 223,779 SH   DFND 3 175,598 0 48,181
BeiGene Ltd SPONSORED ADR 07725L102 197,492 764,317 SH   SOLE 0 372,438 0 391,879
Benefitfocus Inc COM 08180D106 4,437 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 4,422 305,357 SH   DFND 2 97,676 0 207,681
Benefitfocus Inc COM 08180D106 1,585 109,439 SH   DFND 3 109,439 0 0
Benefitfocus Inc COM 08180D106 3,278 226,368 SH   SOLE 0 226,368 0 0
Berkeley Lights Inc COM 084310101 36,739 410,901 SH   DFND 1 410,901 0 0
Berkeley Lights Inc COM 084310101 8,298 92,805 SH   DFND 2 76,131 0 16,674
Berkeley Lights Inc COM 084310101 12,852 143,747 SH   DFND 3 102,243 0 41,504
Berkeley Lights Inc COM 084310101 11,588 129,607 SH   SOLE 0 129,607 0 0
Beyond Meat Inc COM 08862E109 90,870 726,960 SH   DFND 1 726,960 0 0
Beyond Meat Inc COM 08862E109 404,642 3,237,136 SH   DFND 2 1,061,228 0 2,175,908
Beyond Meat Inc COM 08862E109 53,530 428,243 SH   DFND 3 309,166 0 119,077
Beyond Meat Inc COM 08862E109 116,254 930,032 SH   SOLE 0 449,380 0 480,652
Bilibili Inc ADR SPONSORED ADR 090040106 24,210 282,426 SH   DFND 1 282,426 0 0
Biomarin Pharmaceutical Inc COM 09061G101 6 74 SH   DFND 3 74 0 0
BlackRock Floating Rate Income COM 091941104 9,246 784,230 SH   DFND 1 784,230 0 0
Blackline COM 09239B109 72,258 541,742 SH   DFND 1 541,742 0 0
Blackline COM 09239B109 44,815 335,993 SH   DFND 2 122,106 0 213,887
Blackline COM 09239B109 17,153 128,599 SH   DFND 3 128,599 0 0
Blackline COM 09239B109 33,649 252,276 SH   SOLE 0 252,276 0 0
Blackrock Inc COM 09247X101 15 21 SH   DFND 3 21 0 0
Blue Apron Holdings Inc CL A 09523Q101 830 148,506 SH   DFND 1 148,506 0 0
Bluebird Bio Inc COM 09609G100 11 259 SH   DFND 1 259 0 0
Bluebird Bio Inc COM 09609G100 628 14,514 SH   DFND 2 14,514 0 0
Bluebird Bio Inc COM 09609G100 370 8,552 SH   DFND 3 8,552 0 0
Booking Holdings Inc COM 09857L108 112,401 50,466 SH   DFND 1 50,466 0 0
Booking Holdings Inc COM 09857L108 336,990 151,302 SH   DFND 2 134,965 0 16,337
Booking Holdings Inc COM 09857L108 72,763 32,669 SH   DFND 3 14,864 0 17,805
Booking Holdings Inc COM 09857L108 227,264 102,037 SH   SOLE 0 94,451 0 7,586
Box Inc COM 10316T104 18 1,015 SH   DFND 3 1,015 0 0
Brady Corp COM 104674106 14 256 SH   DFND 3 256 0 0
BridgeBio Pharma Inc COM 10806X102 102 1,432 SH   DFND 1 1,432 0 0
BridgeBio Pharma Inc COM 10806X102 5,166 72,653 SH   DFND 2 72,653 0 0
BridgeBio Pharma Inc COM 10806X102 3,161 44,447 SH   DFND 3 44,447 0 0
Bristol Myers Squibb COM 110122108 36 583 SH   DFND 3 583 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 3,707 98,872 SH   DFND 1 98,872 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 147 3,912 SH   DFND 2 0 0 3,912
British Amer.Tobacco - ADR SPONSORED ADR 110448107 16 433 SH   DFND 3 433 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,350 116,021 SH   SOLE 0 116,021 0 0
Broadridge Finl.Sltn. COM 11133T103 75,008 489,608 SH   DFND 1 489,608 0 0
Broadridge Finl.Sltn. COM 11133T103 300,630 1,962,338 SH   DFND 2 1,832,618 0 129,720
Broadridge Finl.Sltn. COM 11133T103 58,300 380,550 SH   DFND 3 169,260 0 211,290
Broadridge Finl.Sltn. COM 11133T103 189,238 1,235,235 SH   SOLE 0 1,146,163 0 89,072
Brookfield Renewable COM 11284V105 61,254 1,051,207 SH   DFND 1 1,051,207 0 0
Brookfield Renewable COM 11284V105 181 3,106 SH   DFND 2 3,106 0 0
Brookfield Renewable COM 11284V105 4,267 73,235 SH   DFND 3 73,235 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 24,423 1,057,261 SH   DFND 1 1,057,261 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 4,631 200,483 SH   DFND 2 200,483 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 4,344 188,041 SH   DFND 3 3,241 0 184,800
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 3,044 131,772 SH   SOLE 0 131,772 0 0
CEVA Inc COM 157210105 8,130 178,680 SH   DFND 1 178,680 0 0
CEVA Inc COM 157210105 7,503 164,901 SH   DFND 2 59,380 0 105,521
CEVA Inc COM 157210105 2,750 60,431 SH   DFND 3 60,431 0 0
CEVA Inc COM 157210105 3,754 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 26,129 278,352 SH   DFND 1 278,352 0 0
CH Robinson Worldwide COM NEW 12541W209 977 10,406 SH   DFND 2 0 0 10,406
CH Robinson Worldwide COM NEW 12541W209 88 939 SH   DFND 3 939 0 0
CH Robinson Worldwide COM NEW 12541W209 26,369 280,908 SH   SOLE 0 280,908 0 0
Calavo Growers Inc COM 128246105 8 122 SH   DFND 3 122 0 0
Cargurus Inc COM 141788109 11 332 SH   DFND 3 332 0 0
Carvana COM 146869102 264,502 1,104,209 SH   DFND 1 1,104,209 0 0
Carvana COM 146869102 725,068 3,026,920 SH   DFND 2 1,507,465 0 1,519,455
Carvana COM 146869102 48,306 201,662 SH   DFND 3 161,483 0 40,179
Carvana COM 146869102 352,931 1,473,370 SH   SOLE 0 1,148,141 0 325,229
Cbre Group Inc CL A 12504L109 102,042 1,626,953 SH   DFND 1 1,626,953 0 0
Cbre Group Inc CL A 12504L109 328,250 5,233,582 SH   DFND 2 4,728,075 0 505,507
Cbre Group Inc CL A 12504L109 65,256 1,040,434 SH   DFND 3 476,310 0 564,124
Cbre Group Inc CL A 12504L109 203,260 3,240,749 SH   SOLE 0 2,997,056 0 243,693
Cemex ADR SPON ADR NEW 151290889 25,486 4,929,570 SH   DFND 1 4,929,570 0 0
Cemex ADR SPON ADR NEW 151290889 129,857 25,117,481 SH   DFND 2 9,869,603 0 15,247,878
Cemex ADR SPON ADR NEW 151290889 46,012 8,899,823 SH   DFND 3 724,391 0 8,175,432
Cemex ADR SPON ADR NEW 151290889 2,169 419,603 SH   DFND 4 419,603 0 0
Cerus COM 157085101 8 1,189 SH   DFND 3 1,189 0 0
Chegg COM 163092109 486,468 5,385,450 SH   DFND 1 5,385,450 0 0
Chegg COM 163092109 589,406 6,525,027 SH   DFND 2 5,637,422 0 887,605
Chegg COM 163092109 97,135 1,075,333 SH   DFND 3 758,941 0 316,392
Chegg COM 163092109 270,993 3,000,030 SH   SOLE 0 2,884,365 0 115,665
Chewy Inc CL A 16679L109 253,681 2,822,123 SH   DFND 1 2,822,123 0 0
Chewy Inc CL A 16679L109 272,901 3,035,940 SH   DFND 2 2,855,406 0 180,534
Chewy Inc CL A 16679L109 9,614 106,950 SH   DFND 3 106,950 0 0
Chewy Inc CL A 16679L109 60,711 675,391 SH   SOLE 0 675,391 0 0
Chinook Therapeutics COM 16961L106 6,284 396,187 SH   DFND 1 396,187 0 0
Chinook Therapeutics COM 16961L106 3,843 242,336 SH   DFND 2 96,273 0 146,063
Chinook Therapeutics COM 16961L106 1,413 89,103 SH   DFND 3 89,103 0 0
Chinook Therapeutics COM 16961L106 1,857 117,058 SH   SOLE 0 117,058 0 0
Church & Dwight Co Inc COM 171340102 16 184 SH   DFND 3 184 0 0
Cimpress COM g2143t103 7 80 SH   DFND 3 80 0 0
Cisco Systems COM 17275R102 13,400 299,452 SH   DFND 1 299,452 0 0
Cisco Systems COM 17275R102 414 9,256 SH   DFND 2 0 0 9,256
Cisco Systems COM 17275R102 46 1,027 SH   DFND 3 1,027 0 0
Cisco Systems COM 17275R102 13,439 300,321 SH   SOLE 0 300,321 0 0
Cloudera Inc COM 18914U100 40,741 2,928,928 SH   DFND 1 2,928,928 0 0
Cloudera Inc COM 18914U100 23,204 1,668,166 SH   DFND 2 606,845 0 1,061,321
Cloudera Inc COM 18914U100 8,902 639,944 SH   DFND 3 639,944 0 0
Cloudera Inc COM 18914U100 20,866 1,500,090 SH   SOLE 0 1,500,090 0 0
Cloudflare Inc CL A COM 18915M107 377,978 4,974,053 SH   DFND 1 4,974,053 0 0
Cloudflare Inc CL A COM 18915M107 1,274,406 16,770,710 SH   DFND 2 8,912,932 0 7,857,778
Cloudflare Inc CL A COM 18915M107 133,237 1,753,346 SH   DFND 3 1,105,992 0 647,354
Cloudflare Inc CL A COM 18915M107 483,610 6,364,129 SH   SOLE 0 4,560,288 0 1,803,841
Clovis Oncology COM 189464100 1 142 SH   DFND 3 142 0 0
CoStar Group COM 22160N109 189,679 205,218 SH   DFND 1 205,218 0 0
CoStar Group COM 22160N109 200,289 216,697 SH   DFND 2 204,814 0 11,883
CoStar Group COM 22160N109 7,220 7,811 SH   DFND 3 7,811 0 0
CoStar Group COM 22160N109 44,337 47,969 SH   SOLE 0 47,969 0 0
Coca Cola COM 191216100 23,241 423,789 SH   DFND 1 423,789 0 0
Coca Cola COM 191216100 764 13,938 SH   DFND 2 0 0 13,938
Coca Cola COM 191216100 83 1,520 SH   DFND 3 1,520 0 0
Coca Cola COM 191216100 24,892 453,911 SH   SOLE 0 453,911 0 0
Codexis COM 192005106 40,762 1,867,255 SH   DFND 1 1,867,255 0 0
Codexis COM 192005106 42,431 1,943,705 SH   DFND 2 702,511 0 1,241,194
Codexis COM 192005106 16,053 735,371 SH   DFND 3 735,371 0 0
Codexis COM 192005106 27,267 1,249,067 SH   SOLE 0 1,249,067 0 0
Cohen & Steers Inc COM 19247A100 26 344 SH   DFND 3 344 0 0
Coherus BioSciences COM 19249H103 30 1,703 SH   DFND 3 1,703 0 0
Columbia Sportswear Co COM 198516106 9 100 SH   DFND 3 100 0 0
Commscope Holding Co Inc COM 20337X109 20 1,486 SH   DFND 3 1,486 0 0
Consolidated Edison COM 209115104 52,731 729,640 SH   DFND 1 729,640 0 0
Consolidated Edison COM 209115104 92 1,275 SH   DFND 2 1,275 0 0
Consolidated Edison COM 209115104 2,305 31,901 SH   DFND 3 31,901 0 0
Cooper Cos Inc/The COM 216648402 12,971 35,700 SH   DFND 2 35,700 0 0
Copa Holdings S A CL A P31076105 29,536 382,440 SH   DFND 1 382,440 0 0
Copa Holdings S A CL A P31076105 274,464 3,553,847 SH   DFND 2 2,217,650 0 1,336,197
Copa Holdings S A CL A P31076105 58,227 753,943 SH   DFND 3 56,914 0 697,029
Copa Holdings S A CL A P31076105 2,547 32,977 SH   DFND 4 32,977 0 0
Copa Holdings S A CL A P31076105 21,457 277,829 SH   SOLE 0 277,829 0 0
Coupa Software Inc COM 22266L106 127 375 SH   DFND 3 375 0 0
Credicorp COM G2519Y108 16,943 103,298 SH   DFND 1 103,298 0 0
Credicorp COM G2519Y108 224,830 1,370,749 SH   DFND 2 818,483 0 552,266
Credicorp COM G2519Y108 34,139 208,140 SH   DFND 3 16,706 0 191,434
Credicorp COM G2519Y108 1,655 10,091 SH   DFND 4 10,091 0 0
Credicorp COM G2519Y108 19,937 121,553 SH   SOLE 0 121,553 0 0
CrowdStrike Holdings COM 22788C105 28 132 SH   DFND 3 132 0 0
Cullen/Frost Bankers COM 229899109 9,861 113,042 SH   DFND 1 113,042 0 0
Cullen/Frost Bankers COM 229899109 406 4,658 SH   DFND 2 0 0 4,658
Cullen/Frost Bankers COM 229899109 34 392 SH   DFND 3 392 0 0
Cullen/Frost Bankers COM 229899109 10,576 121,245 SH   SOLE 0 121,245 0 0
CureVac N.V. - Converted at IPO COM N2451R105 151,602 1,870,009 SH   DFND 2 1,870,009 0 0
CureVac N.V. - Converted at IPO COM N2451R105 126,335 1,558,341 SH   SOLE 0 1,558,341 0 0
Curevac N.V. COM N2451R105 94,084 1,160,522 SH   DFND 2 1,160,522 0 0
Curevac N.V. COM N2451R105 17,250 212,784 SH   SOLE 0 212,784 0 0
CyberArk Software Ltd SHS M2682V108 36,176 223,877 SH   DFND 1 223,877 0 0
CyberArk Software Ltd SHS M2682V108 36,062 223,172 SH   DFND 2 81,277 0 141,895
CyberArk Software Ltd SHS M2682V108 13,864 85,796 SH   DFND 3 85,796 0 0
CyberArk Software Ltd SHS M2682V108 18,602 115,118 SH   SOLE 0 115,118 0 0
DTE Energy Co COM 233331107 55,108 453,900 SH   DFND 1 453,900 0 0
DTE Energy Co COM 233331107 102 838 SH   DFND 2 838 0 0
DTE Energy Co COM 233331107 2,852 23,491 SH   DFND 3 23,491 0 0
Dada Nexus Ltd ADR ADS 23344D108 98,703 2,704,200 SH   DFND 1 2,704,200 0 0
Dada Nexus Ltd ADR ADS 23344D108 113,668 3,114,193 SH   DFND 2 1,808,649 0 1,305,544
Dada Nexus Ltd ADR ADS 23344D108 387 10,614 SH   DFND 3 10,614 0 0
Dada Nexus Ltd ADR ADS 23344D108 16,492 451,837 SH   SOLE 0 451,837 0 0
Darden Restaurants COM 237194105 10 84 SH   DFND 3 84 0 0
Datadog COM 23804L103 152,683 1,551,027 SH   DFND 1 1,551,027 0 0
Datadog COM 23804L103 279,003 2,834,246 SH   DFND 2 2,593,076 0 241,170
Datadog COM 23804L103 36,955 375,411 SH   DFND 3 191,795 0 183,616
Datadog COM 23804L103 133,997 1,361,208 SH   SOLE 0 1,280,770 0 80,438
Deere & Co COM 244199105 56,419 209,696 SH   DFND 1 209,696 0 0
Deere & Co COM 244199105 10,924 40,602 SH   DFND 2 24,843 0 15,759
Deere & Co COM 244199105 29,822 110,843 SH   DFND 3 70,519 0 40,324
Denali Therapeutics COM 24823R105 195,056 2,328,754 SH   DFND 1 2,328,754 0 0
Denali Therapeutics COM 24823R105 203,786 2,432,974 SH   DFND 2 2,294,500 0 138,474
Denali Therapeutics COM 24823R105 16,739 199,839 SH   DFND 3 166,330 0 33,509
Denali Therapeutics COM 24823R105 605,475 7,228,689 SH   SOLE 0 7,228,689 0 0
Dexcom Inc COM 252131107 268,013 724,908 SH   DFND 1 724,908 0 0
Dexcom Inc COM 252131107 1,226,097 3,316,286 SH   DFND 2 1,057,322 0 2,258,964
Dexcom Inc COM 252131107 162,115 438,481 SH   DFND 3 327,783 0 110,698
Dexcom Inc COM 252131107 360,170 974,169 SH   SOLE 0 484,628 0 489,541
Digimarc COM 25381B101 8,793 186,145 SH   DFND 1 186,145 0 0
Digimarc COM 25381B101 14,450 305,880 SH   DFND 2 111,007 0 194,873
Digimarc COM 25381B101 5,380 113,889 SH   DFND 3 113,889 0 0
Digimarc COM 25381B101 7,309 154,711 SH   SOLE 0 154,711 0 0
Dolby Laboratories 'A' COM 25659T107 13,781 141,879 SH   DFND 1 141,879 0 0
Dolby Laboratories 'A' COM 25659T107 525 5,407 SH   DFND 2 0 0 5,407
Dolby Laboratories 'A' COM 25659T107 47 489 SH   DFND 3 489 0 0
Dolby Laboratories 'A' COM 25659T107 14,121 145,382 SH   SOLE 0 145,382 0 0
Doordash Inc COM 25809K105 43,983 308,115 SH   DFND 1 308,115 0 0
Doordash Inc COM 25809K105 70,626 494,756 SH   DFND 2 453,313 0 41,443
Doordash Inc COM 25809K105 8,747 61,277 SH   DFND 3 32,540 0 28,737
Doordash Inc COM 25809K105 99,417 696,443 SH   SOLE 0 683,942 0 12,501
Dropbox CL A 26210C104 20 923 SH   DFND 3 923 0 0
EOG Resources COM 26875P101 46,813 938,703 SH   DFND 1 938,703 0 0
EOG Resources COM 26875P101 174,873 3,506,576 SH   DFND 2 3,266,203 0 240,373
EOG Resources COM 26875P101 23,821 477,670 SH   DFND 3 240,895 0 236,775
EOG Resources COM 26875P101 111,515 2,236,114 SH   SOLE 0 2,065,610 0 170,504
EPAM Systems COM 29414B104 41 115 SH   DFND 3 115 0 0
Ecolab COM 278865100 39,670 183,350 SH   DFND 1 183,350 0 0
Ecolab COM 278865100 19,897 91,964 SH   DFND 2 77,957 0 14,007
Ecolab COM 278865100 21,000 97,062 SH   DFND 3 61,739 0 35,323
Edwards Lifesciences Corp COM 28176E108 140 1,535 SH   DFND 1 1,535 0 0
Edwards Lifesciences Corp COM 28176E108 21,015 230,354 SH   DFND 2 230,354 0 0
Edwards Lifesciences Corp COM 28176E108 4,418 48,422 SH   DFND 3 48,422 0 0
Emergent Biosolutions Inc COM 29089Q105 36 407 SH   DFND 3 407 0 0
Equifax COM 294429105 8 43 SH   DFND 3 43 0 0
Estee Lauder 'A' COM 518439104 98,265 369,155 SH   DFND 1 369,155 0 0
Estee Lauder 'A' COM 518439104 397,290 1,492,507 SH   DFND 2 1,396,996 0 95,511
Estee Lauder 'A' COM 518439104 75,156 282,341 SH   DFND 3 126,822 0 155,519
Estee Lauder 'A' COM 518439104 239,979 901,532 SH   SOLE 0 833,854 0 67,678
Etsy COM 29786A106 127 714 SH   DFND 3 714 0 0
Eventbrite Inc Class A COM CL A 29975E109 29,078 1,606,535 SH   DFND 1 1,606,535 0 0
Eventbrite Inc Class A COM CL A 29975E109 28,907 1,597,098 SH   DFND 2 1,508,511 0 88,587
Eventbrite Inc Class A COM CL A 29975E109 1,137 62,821 SH   DFND 3 62,821 0 0
Eventbrite Inc Class A COM CL A 29975E109 4,397 242,948 SH   SOLE 0 242,948 0 0
EverQuote Inc COM CL A 30041R108 21,195 567,467 SH   DFND 1 567,467 0 0
EverQuote Inc COM CL A 30041R108 10,842 290,281 SH   DFND 2 105,159 0 185,122
EverQuote Inc COM CL A 30041R108 4,045 108,287 SH   DFND 3 108,287 0 0
EverQuote Inc COM CL A 30041R108 6,998 187,350 SH   SOLE 0 187,350 0 0
Everbridge Inc COM 29978A104 33,181 222,586 SH   DFND 1 222,586 0 0
Everbridge Inc COM 29978A104 30,749 206,270 SH   DFND 2 75,239 0 131,031
Everbridge Inc COM 29978A104 11,814 79,253 SH   DFND 3 79,253 0 0
Everbridge Inc COM 29978A104 22,129 148,446 SH   SOLE 0 148,446 0 0
Eversource Energy COM 30040W108 46,210 534,156 SH   DFND 1 534,156 0 0
Eversource Energy COM 30040W108 93 1,077 SH   DFND 2 1,077 0 0
Eversource Energy COM 30040W108 2,373 27,428 SH   DFND 3 27,428 0 0
Exact Sciences COM 30063P105 52,773 398,320 SH   DFND 1 398,320 0 0
Exact Sciences COM 30063P105 53,912 406,910 SH   DFND 2 174,800 0 232,110
Exact Sciences COM 30063P105 24,036 181,415 SH   DFND 3 173,269 0 8,146
Exact Sciences COM 30063P105 21,543 162,599 SH   SOLE 0 162,599 0 0
Exelon Corporation COM 30161N101 819 19,387 SH   DFND 1 19,387 0 0
Expeditors Intl COM 302130109 12 130 SH   DFND 3 130 0 0
Exponent COM 30214U102 22 243 SH   DFND 3 243 0 0
Extreme Networks COM 30226D106 4 588 SH   DFND 3 588 0 0
Facebook Cl.A CL A 30303M102 294,466 1,078,000 SH   DFND 1 1,078,000 0 0
Facebook Cl.A CL A 30303M102 1,863,536 6,822,141 SH   DFND 2 2,964,890 0 3,857,251
Facebook Cl.A CL A 30303M102 209,975 768,689 SH   DFND 3 515,922 0 252,767
Facebook Cl.A CL A 30303M102 679,681 2,488,214 SH   SOLE 0 1,594,998 0 893,216
Farfetch ORD SHS CL A 30744W107 114,069 1,787,642 SH   DFND 1 1,787,642 0 0
Farfetch ORD SHS CL A 30744W107 375,292 5,881,404 SH   DFND 2 5,465,311 0 416,093
Farfetch ORD SHS CL A 30744W107 86,017 1,348,015 SH   DFND 3 679,797 0 668,218
Farfetch ORD SHS CL A 30744W107 327,798 5,137,101 SH   SOLE 0 4,362,477 0 774,624
Faro Technologies COM 311642102 7,184 101,715 SH   DFND 1 101,715 0 0
Faro Technologies COM 311642102 12,061 170,762 SH   DFND 2 61,795 0 108,967
Faro Technologies COM 311642102 4,644 65,751 SH   DFND 3 65,751 0 0
Faro Technologies COM 311642102 7,620 107,880 SH   SOLE 0 107,880 0 0
Fastenal COM 311900104 44,746 916,364 SH   DFND 1 916,364 0 0
Fastenal COM 311900104 20,049 410,597 SH   DFND 2 381,745 0 28,852
Fastenal COM 311900104 4,525 92,659 SH   DFND 3 59,991 0 32,668
Fastenal COM 311900104 38,441 787,234 SH   SOLE 0 787,234 0 0
Ferrari NV COM N3167Y103 462,338 2,003,000 SH   SOLE 0 2,003,000 0 0
Ferrari NV COM N3167Y103 2,259,597 9,789,320 SH   DFND 2 7,799,944 0 1,989,376
Fiat Chrysler Automobiles SHS N31738102 532,841 29,705,863 SH   DFND 2 22,238,088 0 7,467,775
Fibrogen Inc COM 31572Q808 13 347 SH   DFND 3 347 0 0
First Republic Bank COM 33616C100 248,740 1,692,915 SH   DFND 1 1,692,915 0 0
First Republic Bank COM 33616C100 293,242 1,995,797 SH   DFND 2 1,894,938 0 100,859
First Republic Bank COM 33616C100 17,088 116,303 SH   DFND 3 96,319 0 19,984
First Republic Bank COM 33616C100 61,019 415,293 SH   SOLE 0 415,293 0 0
FirstCash COM 33767D105 19,443 277,600 SH   DFND 1 277,600 0 0
FirstCash COM 33767D105 1,079 15,400 SH   DFND 3 15,400 0 0
Fortis COM 349553107 769 18,837 SH   DFND 1 18,837 0 0
Fortive Corp COM 34959J108 7,724 109,062 SH   DFND 2 109,062 0 0
Fortive Corp COM 34959J108 11 157 SH   DFND 3 157 0 0
Fox COM 35137L105 10 343 SH   DFND 3 343 0 0
Gentex Corp COM 371901109 16 478 SH   DFND 3 478 0 0
Glaukos Corp COM 377322102 170,050 2,259,502 SH   DFND 1 2,259,502 0 0
Glaukos Corp COM 377322102 134,251 1,783,824 SH   DFND 2 1,643,011 0 140,813
Glaukos Corp COM 377322102 32,919 437,409 SH   DFND 3 311,715 0 125,694
Glaukos Corp COM 377322102 28,884 383,789 SH   SOLE 0 383,789 0 0
Global Blood Therapeutics Inc COM 37890U108 41 950 SH   DFND 3 950 0 0
Glu Mobile COM 379890106 47 5,180 SH   DFND 3 5,180 0 0
Grifols ADR SP ADR REP B NVT 398438408 55,255 2,996,485 SH   DFND 2 2,172,348 0 824,137
Grifols ADR SP ADR REP B NVT 398438408 7,126 386,447 SH   SOLE 0 386,447 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 62,254 861,527 SH   DFND 2 779,558 0 81,969
HDFC Bank ADR ADR REPS 3 SHS 40415F101 12,379 171,311 SH   DFND 3 76,175 0 95,136
HDFC Bank ADR ADR REPS 3 SHS 40415F101 81,123 1,122,661 SH   SOLE 0 1,013,184 0 109,477
HEICO COM 422806109 12,570 94,942 SH   DFND 1 94,942 0 0
HEICO COM 422806109 8,223 62,106 SH   SOLE 0 62,106 0 0
HEICO 'A' CL A 422806208 59,229 505,971 SH   DFND 1 505,971 0 0
HEICO 'A' CL A 422806208 88,041 752,098 SH   DFND 2 715,619 0 36,479
HEICO 'A' CL A 422806208 2,822 24,107 SH   DFND 3 24,107 0 0
HEICO 'A' CL A 422806208 9,067 77,460 SH   SOLE 0 77,460 0 0
HUYA ADR ADS REP SHS A 44852D108 36,917 1,852,330 SH   DFND 1 1,852,330 0 0
HUYA ADR ADS REP SHS A 44852D108 5,357 268,783 SH   DFND 2 268,783 0 0
HUYA ADR ADS REP SHS A 44852D108 7,759 389,295 SH   DFND 3 4,531 0 384,764
HUYA ADR ADS REP SHS A 44852D108 9,812 492,323 SH   SOLE 0 492,323 0 0
Halozyme Therapeutics COM 40637H109 41 954 SH   DFND 3 954 0 0
Harris Corp COM 502431109 11 57 SH   DFND 3 57 0 0
Health Catalyst Inc COM 42225T107 64 1,468 SH   DFND 1 1,468 0 0
Health Catalyst Inc COM 42225T107 3,260 74,885 SH   DFND 2 74,885 0 0
Health Catalyst Inc COM 42225T107 1,989 45,700 SH   DFND 3 45,700 0 0
Healthcare Services Group Inc COM 421906108 4 153 SH   DFND 3 153 0 0
Heron Therapeutics Inc COM 427746102 7 326 SH   DFND 3 326 0 0
Hillenbrand COM 431571108 7 167 SH   DFND 3 167 0 0
Home Depot COM 437076102 16 61 SH   DFND 3 61 0 0
Homology Medicines COM 438083107 5 481 SH   DFND 3 481 0 0
Hormel Foods Corp COM 440452100 12 247 SH   DFND 3 247 0 0
Howard Hughes COM 44267D107 51,093 647,317 SH   DFND 1 647,317 0 0
Howard Hughes COM 44267D107 117,394 1,487,317 SH   DFND 2 1,381,866 0 105,451
Howard Hughes COM 44267D107 25,420 322,056 SH   DFND 3 152,058 0 169,998
Howard Hughes COM 44267D107 80,164 1,015,639 SH   SOLE 0 938,712 0 76,927
Hubbell COM 443510607 14 92 SH   DFND 3 92 0 0
Hubspot Inc COM 443573100 61 155 SH   DFND 3 155 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 3,294 102,877 SH   DFND 1 102,877 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 6,120 191,146 SH   DFND 3 0 0 191,146
ICICI Bank ADR ADR 45104G104 117,057 7,877,347 SH   DFND 1 7,877,347 0 0
ICICI Bank ADR ADR 45104G104 121,526 8,178,064 SH   DFND 2 7,469,347 0 708,717
ICICI Bank ADR ADR 45104G104 59,538 4,006,614 SH   DFND 3 2,123,076 0 1,883,538
ICICI Bank ADR ADR 45104G104 7,558 508,602 SH   DFND 4 508,602 0 0
ICICI Bank ADR ADR 45104G104 128,995 8,680,654 SH   SOLE 0 8,120,300 0 560,354
IPG Photonics Corp COM 44980X109 27,022 120,747 SH   DFND 1 120,747 0 0
IPG Photonics Corp COM 44980X109 24,940 111,444 SH   DFND 2 40,557 0 70,887
IPG Photonics Corp COM 44980X109 9,408 42,038 SH   DFND 3 42,038 0 0
IPG Photonics Corp COM 44980X109 16,479 73,636 SH   SOLE 0 73,636 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 29,358 3,437,662 SH   DFND 1 3,437,662 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 7,143 836,416 SH   DFND 2 836,416 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 149 17,392 SH   DFND 3 17,392 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 5,905 691,490 SH   SOLE 0 691,490 0 0
Ii-Vi Inc COM 902104108 48 634 SH   DFND 3 634 0 0
Illumina COM 452327109 668,019 1,805,456 SH   DFND 1 1,805,456 0 0
Illumina COM 452327109 4,344,889 11,742,942 SH   DFND 2 7,907,111 0 3,835,831
Illumina COM 452327109 292,336 790,096 SH   DFND 3 562,973 0 227,123
Illumina COM 452327109 2,033,619 5,496,268 SH   SOLE 0 4,716,640 0 779,628
InMode SHS M5425M103 16 346 SH   DFND 3 346 0 0
Incyte Corp COM 45337C102 16 184 SH   DFND 3 184 0 0
Infinera COM 45667G103 30 2,842 SH   DFND 3 2,842 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 16,274 960,137 SH   DFND 1 960,137 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 15,041 887,361 SH   DFND 2 205,437 0 681,924
Infosys Ltd ADR SPONSORED ADR 456788108 7,335 432,737 SH   DFND 3 310,320 0 122,417
Infosys Ltd ADR SPONSORED ADR 456788108 3,087 182,140 SH   DFND 4 182,140 0 0
Inogen Inc COM 45780L104 7 149 SH   DFND 3 149 0 0
Inphi Corp COM 45772F107 85 532 SH   DFND 3 532 0 0
Insmed Inc COM 457669307 25 760 SH   DFND 3 760 0 0
Inspire Medical Systems COM 457730109 37 196 SH   DFND 3 196 0 0
Interactive Brokers Group COM 45841N107 32,424 532,232 SH   DFND 1 532,232 0 0
Interactive Brokers Group COM 45841N107 123,279 2,023,615 SH   DFND 2 1,896,717 0 126,898
Interactive Brokers Group COM 45841N107 24,677 405,068 SH   DFND 3 189,510 0 215,558
Interactive Brokers Group COM 45841N107 74,598 1,224,522 SH   SOLE 0 1,129,063 0 95,459
Intercept Pharmaceuticals Inc COM 45845P108 2 86 SH   DFND 3 86 0 0
Intersect ENT COM 46071F103 8 340 SH   DFND 3 340 0 0
Intuitive Surgical COM NEW 46120E602 118,841 145,265 SH   DFND 1 145,265 0 0
Intuitive Surgical COM NEW 46120E602 904,389 1,105,475 SH   DFND 2 345,695 0 759,780
Intuitive Surgical COM NEW 46120E602 76,131 93,058 SH   DFND 3 72,606 0 20,452
Intuitive Surgical COM NEW 46120E602 463,600 566,679 SH   SOLE 0 400,804 0 165,875
Invesco Senior Income Trust COM 46131H107 10,177 2,556,949 SH   DFND 1 2,556,949 0 0
Invesco Senior Income Trust COM 46131H107 2,542 638,746 SH   DFND 3 638,746 0 0
Ionis Pharmaceuticals COM 462222100 86 1,525 SH   DFND 1 1,525 0 0
Ionis Pharmaceuticals COM 462222100 4,359 77,104 SH   DFND 2 77,104 0 0
Ionis Pharmaceuticals COM 462222100 2,691 47,589 SH   DFND 3 47,589 0 0
Ironwood Pharmaceuticals Inc COM 46333X108 11 990 SH   DFND 3 990 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 14,936 2,452,615 SH   DFND 1 2,452,615 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 139,369 22,884,956 SH   DFND 2 12,288,345 0 10,596,611
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 57,429 9,430,072 SH   DFND 3 786,287 0 8,643,785
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 2,796 459,075 SH   DFND 4 459,075 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 12,780 2,098,498 SH   SOLE 0 2,098,498 0 0
Itron Inc COM 465741106 19 199 SH   DFND 3 199 0 0
J&J Snack Foods Corp COM 466032109 12 79 SH   DFND 3 79 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 129,755 1,476,163 SH   DFND 1 1,476,163 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 8,433 95,934 SH   DFND 2 95,934 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 644 7,322 SH   DFND 3 7,322 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 25,661 291,937 SH   SOLE 0 291,937 0 0
JDS Uniphase Corporation COM 925550105 15 996 SH   DFND 3 996 0 0
Jack Henry & Associates COM 426281101 12 73 SH   DFND 3 73 0 0
Jefferies Financial Group Inc COM 47233W109 37,522 1,525,304 SH   DFND 1 1,525,304 0 0
Jefferies Financial Group Inc COM 47233W109 138,073 5,612,704 SH   DFND 2 5,207,715 0 404,989
Jefferies Financial Group Inc COM 47233W109 28,482 1,157,800 SH   DFND 3 520,795 0 637,005
Jefferies Financial Group Inc COM 47233W109 96,819 3,935,734 SH   SOLE 0 3,637,496 0 298,238
John Wiley & Sons Inc COM 968223206 7 159 SH   DFND 3 159 0 0
Johnson & Johnson COM 478160104 14 88 SH   DFND 3 88 0 0
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 361,443 8,957,703 SH   DFND 2 8,833,471 0 124,232
KE Holdings ADR ADR 482497104 116,529 1,893,556 SH   DFND 1 1,893,556 0 0
KE Holdings ADR ADR 482497104 636,739 10,346,744 SH   DFND 2 4,918,569 0 5,428,175
KE Holdings ADR ADR 482497104 42,229 686,207 SH   DFND 3 452,546 0 233,661
KE Holdings ADR ADR 482497104 289,541 4,704,924 SH   SOLE 0 3,746,143 0 958,781
Kaleido Biosciences Inc COM 483347100 2,243 246,500 SH   DFND 1 246,500 0 0
Kaleido Biosciences Inc COM 483347100 1,761 193,500 SH   SOLE 0 193,500 0 0
Keysight Technologies COM 49338L103 21 157 SH   DFND 3 157 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 69,632 1,598,904 SH   DFND 1 1,598,904 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 220,070 5,053,264 SH   DFND 2 2,714,506 0 2,338,758
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 13,116 301,175 SH   DFND 3 4,873 0 296,302
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 17,122 393,153 SH   SOLE 0 393,153 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 23 1,900 SH   DFND 2 1,900 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 1,933 157,540 SH   DFND 3 157,540 0 0
LUFAX Holdings LTD COM 54975P102 81,937 5,770,215 SH   DFND 1 5,770,215 0 0
LUFAX Holdings LTD COM 54975P102 148,412 10,451,579 SH   DFND 2 5,685,112 0 4,766,467
LUFAX Holdings LTD COM 54975P102 262 18,431 SH   DFND 3 18,431 0 0
LUFAX Holdings LTD COM 54975P102 11,399 802,735 SH   SOLE 0 802,735 0 0
Lci Industries COM 50189K103 12 89 SH   DFND 3 89 0 0
Lemonade Inc COM 52567D107 146,307 1,194,339 SH   DFND 1 1,194,339 0 0
Lemonade Inc COM 52567D107 157,734 1,287,626 SH   DFND 2 1,211,123 0 76,503
Lemonade Inc COM 52567D107 5,624 45,907 SH   DFND 3 45,907 0 0
Lemonade Inc COM 52567D107 92,418 754,430 SH   SOLE 0 754,430 0 0
LendingTree COM 52603B107 70,102 256,042 SH   DFND 1 256,042 0 0
LendingTree COM 52603B107 158,238 577,955 SH   DFND 2 418,949 0 159,006
LendingTree COM 52603B107 46,600 170,204 SH   DFND 3 123,270 0 46,934
LendingTree COM 52603B107 94,319 344,493 SH   SOLE 0 327,194 0 17,299
Liberty Broadband Corp COM 530307305 11 71 SH   DFND 3 71 0 0
Lightspeed POS COM 53227R106 22 312 SH   DFND 3 312 0 0
Lindblad Expeditions Holdings COM 535219109 11,984 700,000 SH   SOLE 0 700,000 0 0
LivePerson Inc COM 538146101 30,635 492,291 SH   DFND 1 492,291 0 0
LivePerson Inc COM 538146101 22,815 366,617 SH   DFND 2 131,267 0 235,350
LivePerson Inc COM 538146101 8,515 136,838 SH   DFND 3 136,838 0 0
LivePerson Inc COM 538146101 15,426 247,880 SH   SOLE 0 247,880 0 0
Liveramp Holdings Inc COM 53815P108 37,342 510,201 SH   DFND 1 510,201 0 0
Liveramp Holdings Inc COM 53815P108 22,914 313,074 SH   DFND 2 113,487 0 199,587
Liveramp Holdings Inc COM 53815P108 8,829 120,637 SH   DFND 3 120,637 0 0
Liveramp Holdings Inc COM 53815P108 19,181 262,075 SH   SOLE 0 262,075 0 0
Lowes Cos COM 548661107 12 72 SH   DFND 3 72 0 0
Lumentum Hdgs COM 55024U109 17 183 SH   DFND 3 183 0 0
Lyft Inc Class A Common CL A COM 55087P104 108,674 2,211,965 SH   DFND 1 2,211,965 0 0
Lyft Inc Class A Common CL A COM 55087P104 209,367 4,261,491 SH   DFND 2 3,982,746 0 278,745
Lyft Inc Class A Common CL A COM 55087P104 38,601 785,683 SH   DFND 3 386,038 0 399,645
Lyft Inc Class A Common CL A COM 55087P104 195,069 3,970,474 SH   SOLE 0 3,797,289 0 173,185
M&T Bank COM 55261F104 9,296 73,026 SH   DFND 2 73,026 0 0
MRC Global COM 55345K103 4,310 650,000 SH   SOLE 0 650,000 0 0
MakeMyTrip SHS V5633W109 77,750 2,632,913 SH   DFND 2 1,967,029 0 665,884
Markel Corp COM 570535104 58,277 56,399 SH   DFND 1 56,399 0 0
Markel Corp COM 570535104 207,151 200,475 SH   DFND 2 186,920 0 13,555
Markel Corp COM 570535104 43,177 41,786 SH   DFND 3 19,182 0 22,604
Markel Corp COM 570535104 134,021 129,702 SH   SOLE 0 120,130 0 9,572
MarketAxess Holdings COM 57060D108 328,815 576,303 SH   DFND 1 576,303 0 0
MarketAxess Holdings COM 57060D108 397,501 696,686 SH   DFND 2 556,458 0 140,228
MarketAxess Holdings COM 57060D108 63,275 110,900 SH   DFND 3 100,206 0 10,694
MarketAxess Holdings COM 57060D108 119,868 210,089 SH   SOLE 0 210,089 0 0
Martin Marietta Materials COM 573284106 110,325 388,508 SH   DFND 1 388,508 0 0
Martin Marietta Materials COM 573284106 345,896 1,218,073 SH   DFND 2 1,133,619 0 84,454
Martin Marietta Materials COM 573284106 72,343 254,757 SH   DFND 3 117,024 0 137,733
Martin Marietta Materials COM 573284106 238,475 839,788 SH   SOLE 0 781,032 0 58,756
Masimo Corp COM 574795100 102 380 SH   DFND 1 380 0 0
Masimo Corp COM 574795100 5,154 19,205 SH   DFND 2 19,205 0 0
Masimo Corp COM 574795100 3,162 11,782 SH   DFND 3 11,782 0 0
Mastercard Inc-Class A CL A 57636Q104 456,915 1,280,088 SH   DFND 1 1,280,088 0 0
Mastercard Inc-Class A CL A 57636Q104 972,789 2,725,357 SH   DFND 2 2,549,477 0 175,880
Mastercard Inc-Class A CL A 57636Q104 154,916 434,010 SH   DFND 3 211,576 0 222,434
Mastercard Inc-Class A CL A 57636Q104 499,398 1,399,108 SH   SOLE 0 1,306,952 0 92,156
Maxlinear Inc COM 57776J100 33 861 SH   DFND 3 861 0 0
McDonald's COM 580135101 18,389 85,696 SH   DFND 1 85,696 0 0
McDonald's COM 580135101 734 3,422 SH   DFND 2 0 0 3,422
McDonald's COM 580135101 63 294 SH   DFND 3 294 0 0
McDonald's COM 580135101 18,832 87,764 SH   SOLE 0 87,764 0 0
Medtronic COM G5960L103 11,699 99,874 SH   DFND 1 99,874 0 0
Medtronic COM G5960L103 372 3,179 SH   DFND 2 0 0 3,179
Medtronic COM G5960L103 40 340 SH   DFND 3 340 0 0
Medtronic COM G5960L103 12,341 105,354 SH   SOLE 0 105,354 0 0
MercadoLibre COM 58733R102 409,935 244,705 SH   DFND 1 244,705 0 0
MercadoLibre COM 58733R102 6,695,152 3,996,581 SH   DFND 2 3,293,323 0 703,258
MercadoLibre COM 58733R102 122,799 73,303 SH   DFND 3 57,134 0 16,169
MercadoLibre COM 58733R102 12,730 7,599 SH   DFND 4 7,599 0 0
MercadoLibre COM 58733R102 719,567 429,536 SH   SOLE 0 429,536 0 0
Mercury Computer Systems COM 589378108 19 217 SH   DFND 3 217 0 0
Meredith Corp COM 589433101 6 320 SH   DFND 3 320 0 0
Mettler-Toledo COM 592688105 93,965 82,449 SH   DFND 1 82,449 0 0
Mettler-Toledo COM 592688105 550,095 482,675 SH   DFND 2 343,637 0 139,038
Mettler-Toledo COM 592688105 3,267 2,867 SH   DFND 3 2,867 0 0
Mettler-Toledo COM 592688105 34,511 30,281 SH   SOLE 0 30,281 0 0
MiMedx Group COM 602496101 4 484 SH   DFND 3 484 0 0
Microsoft COM 594918104 214,779 965,646 SH   DFND 1 965,646 0 0
Microsoft COM 594918104 710,964 3,196,491 SH   DFND 2 2,981,952 0 214,539
Microsoft COM 594918104 136,981 615,867 SH   DFND 3 276,394 0 339,473
Microsoft COM 594918104 463,150 2,082,320 SH   SOLE 0 1,940,489 0 141,831
Mobile Telesystems ADR SPONSORED ADR 607409109 266 29,700 SH   DFND 1 29,700 0 0
Moderna Inc COM 60770K107 400,677 3,835,331 SH   DFND 1 3,835,331 0 0
Moderna Inc COM 60770K107 1,303,608 12,478,298 SH   DFND 2 8,808,314 0 3,669,984
Moderna Inc COM 60770K107 157,374 1,506,403 SH   DFND 3 973,542 0 532,861
Moderna Inc COM 60770K107 678,244 6,492,239 SH   SOLE 0 5,681,031 0 811,208
Modine Manufacturing Co COM 607828100 7 558 SH   DFND 3 558 0 0
MongoDB Inc COM 60937P106 87 241 SH   DFND 3 241 0 0
Monolithic Power Systems Inc COM 609839105 29 79 SH   DFND 3 79 0 0
Moody's Corp COM 615369105 201,278 693,488 SH   DFND 1 693,488 0 0
Moody's Corp COM 615369105 742,161 2,557,059 SH   DFND 2 2,377,057 0 180,002
Moody's Corp COM 615369105 152,820 526,529 SH   DFND 3 235,312 0 291,217
Moody's Corp COM 615369105 478,677 1,649,247 SH   SOLE 0 1,524,523 0 124,724
NIO Inc ADR SPON ADS 62914V106 181,773 3,729,444 SH   DFND 1 3,729,444 0 0
NIO Inc ADR SPON ADS 62914V106 3,472,949 71,254,598 SH   DFND 2 49,887,918 0 21,366,680
NIO Inc ADR SPON ADS 62914V106 108,618 2,228,524 SH   DFND 3 1,700,883 0 527,641
NIO Inc ADR SPON ADS 62914V106 1,496,084 30,695,202 SH   SOLE 0 26,433,618 0 4,261,584
NV5 Global COM 62945V109 10 128 SH   DFND 3 128 0 0
NVIDIA COM 67066G104 287,987 551,488 SH   DFND 1 551,488 0 0
NVIDIA COM 67066G104 1,275,665 2,442,867 SH   DFND 2 1,003,415 0 1,439,452
NVIDIA COM 67066G104 96,277 184,368 SH   DFND 3 142,272 0 42,096
NVIDIA COM 67066G104 790,428 1,513,650 SH   SOLE 0 1,214,921 0 298,729
Nanobiotix ADR COM 63009J107 14,039 850,841 SH   DFND 1 850,841 0 0
Nanobiotix ADR COM 63009J107 9,061 549,159 SH   SOLE 0 549,159 0 0
National Instruments Corp COM 636518102 24,609 560,059 SH   DFND 1 560,059 0 0
National Instruments Corp COM 636518102 7,545 171,709 SH   DFND 2 56,826 0 114,883
National Instruments Corp COM 636518102 2,631 59,883 SH   DFND 3 59,883 0 0
National Instruments Corp COM 636518102 25,453 579,259 SH   SOLE 0 579,259 0 0
Nektar Therapeutics COM 640268108 26 1,511 SH   DFND 3 1,511 0 0
NetEase.com ADR SPONSORED ADR 64110W102 91,121 951,459 SH   DFND 1 951,459 0 0
NetEase.com ADR SPONSORED ADR 64110W102 553,560 5,780,100 SH   DFND 2 1,723,353 0 4,056,747
NetEase.com ADR SPONSORED ADR 64110W102 45,970 480,003 SH   DFND 3 366,246 0 113,757
NetEase.com ADR SPONSORED ADR 64110W102 171,406 1,789,771 SH   SOLE 0 868,341 0 921,430
Netflix Inc COM 64110L106 708,133 1,309,587 SH   DFND 1 1,309,587 0 0
Netflix Inc COM 64110L106 2,253,842 4,168,146 SH   DFND 2 2,056,397 0 2,111,749
Netflix Inc COM 64110L106 213,487 394,812 SH   DFND 3 286,705 0 108,107
Netflix Inc COM 64110L106 1,216,141 2,249,073 SH   SOLE 0 1,782,070 0 467,003
Nevro Corp COM 64157F103 26 148 SH   DFND 3 148 0 0
New Relic COM 64829B100 12 184 SH   DFND 3 184 0 0
Newmont Mining COM 651639106 192 3,200 SH   DFND 2 3,200 0 0
NextEra Energy COM 65339F101 930 12,056 SH   DFND 1 12,056 0 0
Nike COM 654106103 16 110 SH   DFND 3 110 0 0
Novocure Ltd ORD SHS G6674U108 420,797 2,431,789 SH   DFND 1 2,431,789 0 0
Novocure Ltd ORD SHS G6674U108 617,196 3,566,780 SH   DFND 2 3,092,633 0 474,147
Novocure Ltd ORD SHS G6674U108 99,572 575,427 SH   DFND 3 395,750 0 179,677
Novocure Ltd ORD SHS G6674U108 291,932 1,687,079 SH   SOLE 0 1,610,448 0 76,631
Nucana Plc ADR SPONSORED ADR 67022C106 9,341 2,080,341 SH   DFND 1 2,080,341 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 5,563 1,238,989 SH   SOLE 0 1,238,989 0 0
Nutanix Inc COM 67059N108 19 586 SH   DFND 3 586 0 0
Nuveen Senior Income Fund COM 67067Y104 1,946 375,012 SH   DFND 1 375,012 0 0
On Semiconductor Corp COM 682189105 27 833 SH   DFND 3 833 0 0
OneConnect Financial Technology ADR COM 68248T105 13,330 676,301 SH   DFND 2 246,783 0 429,518
OneConnect Financial Technology ADR COM 68248T105 5,167 262,150 SH   DFND 3 262,150 0 0
Outset Medical COM 690145107 18 318 SH   DFND 3 318 0 0
Oxford Industries Inc COM 691497309 5 82 SH   DFND 3 82 0 0
Ozon Holdings COM 69269L104 10,231 247,078 SH   DFND 1 247,078 0 0
Ozon Holdings COM 69269L104 72,141 1,742,112 SH   DFND 2 853,099 0 889,013
Pacific Biosciences of California COM 69404D108 13 508 SH   DFND 3 508 0 0
Pacira BioSciences COM 695127100 56,238 939,804 SH   DFND 1 939,804 0 0
Pacira BioSciences COM 695127100 28,078 469,225 SH   DFND 2 199,941 0 269,284
Pacira BioSciences COM 695127100 15,325 256,096 SH   DFND 3 220,522 0 35,574
Pacira BioSciences COM 695127100 17,872 298,670 SH   SOLE 0 298,670 0 0
PagerDuty COM 69553P100 25 606 SH   DFND 3 606 0 0
Palantir Technologies COM 69608A108 132,452 5,624,297 SH   SOLE 0 5,624,297 0 0
Paychex COM 704326107 11 117 SH   DFND 3 117 0 0
Peloton Interactive Inc CL A COM 70614W100 212,846 1,402,884 SH   DFND 1 1,402,884 0 0
Peloton Interactive Inc CL A COM 70614W100 1,603,841 10,571,057 SH   DFND 2 3,308,290 0 7,262,767
Peloton Interactive Inc CL A COM 70614W100 138,324 911,706 SH   DFND 3 715,065 0 196,641
Peloton Interactive Inc CL A COM 70614W100 470,066 3,098,249 SH   SOLE 0 1,501,347 0 1,596,902
Penumbra Inc COM 70975L107 84,693 483,960 SH   DFND 1 483,960 0 0
Penumbra Inc COM 70975L107 91,052 520,297 SH   DFND 2 491,209 0 29,088
Penumbra Inc COM 70975L107 5,843 33,389 SH   DFND 3 33,389 0 0
Penumbra Inc COM 70975L107 20,846 119,120 SH   SOLE 0 119,120 0 0
Pepsico COM 713448108 29,879 201,476 SH   DFND 1 201,476 0 0
Pepsico COM 713448108 1,114 7,509 SH   DFND 2 0 0 7,509
Pepsico COM 713448108 102 686 SH   DFND 3 686 0 0
Pepsico COM 713448108 30,344 204,614 SH   SOLE 0 204,614 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 97,196 8,655,060 SH   DFND 1 8,655,060 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 395,414 35,210,537 SH   DFND 2 14,192,947 0 21,017,590
Petrobras Common ADR SPONSORED ADR 71654V408 83,051 7,395,440 SH   DFND 3 611,004 0 6,784,436
Petrobras Common ADR SPONSORED ADR 71654V408 4,017 357,664 SH   DFND 4 357,664 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 11,348 1,010,506 SH   SOLE 0 1,010,506 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 18,309 1,655,414 SH   DFND 1 1,655,414 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 120,653 10,908,922 SH   DFND 2 5,980,339 0 4,928,583
Pinduoduo Inc ADR SPONSORED ADS 722304102 368,158 2,072,145 SH   DFND 1 2,072,145 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 2,641,433 14,867,071 SH   DFND 2 4,571,683 0 10,295,388
Pinduoduo Inc ADR SPONSORED ADS 722304102 238,468 1,342,194 SH   DFND 3 1,060,530 0 281,664
Pinduoduo Inc ADR SPONSORED ADS 722304102 1,259,332 7,088,040 SH   SOLE 0 4,801,926 0 2,286,114
Pinterest COM 72352L106 28 424 SH   DFND 3 424 0 0
Plantronics Inc COM 727493108 6 234 SH   DFND 3 234 0 0
Procter & Gamble COM 742718109 36,901 265,209 SH   DFND 1 265,209 0 0
Procter & Gamble COM 742718109 1,416 10,180 SH   DFND 2 0 0 10,180
Procter & Gamble COM 742718109 126 905 SH   DFND 3 905 0 0
Procter & Gamble COM 742718109 37,784 271,554 SH   SOLE 0 271,554 0 0
Progyny COM 74340E103 17 408 SH   DFND 3 408 0 0
Proofpoint Inc COM 743424103 21 153 SH   DFND 3 153 0 0
Proto Labs Inc COM 743713109 10 67 SH   DFND 3 67 0 0
Ptc Therapeutics Inc COM 69366J200 15 246 SH   DFND 3 246 0 0
Puma Biotechnology COM 74587V107 3 252 SH   DFND 3 252 0 0
Pure Storage Inc COM 74624M102 32 1,433 SH   DFND 3 1,433 0 0
Q2 Holdings Inc COM 74736L109 35,548 280,946 SH   DFND 1 280,946 0 0
Q2 Holdings Inc COM 74736L109 23,217 183,492 SH   DFND 2 66,736 0 116,756
Q2 Holdings Inc COM 74736L109 8,762 69,245 SH   DFND 3 69,245 0 0
Q2 Holdings Inc COM 74736L109 15,466 122,235 SH   SOLE 0 122,235 0 0
Quaker Chemical Corp COM 747316107 20 78 SH   DFND 3 78 0 0
QuantumScape Corp COM CL A 74767V109 77,126 913,279 SH   SOLE 0 913,279 0 0
Quest Diagnostics COM 74834L100 18 148 SH   DFND 3 148 0 0
Quidel Corp COM 74838J101 21 116 SH   DFND 3 116 0 0
Rambus Inc COM 750917106 11 657 SH   DFND 3 657 0 0
Redfin COM 75737F108 261,965 3,817,065 SH   DFND 1 3,817,065 0 0
Redfin COM 75737F108 250,488 3,649,829 SH   DFND 2 3,436,074 0 213,755
Redfin COM 75737F108 18,293 266,539 SH   DFND 3 219,896 0 46,643
Redfin COM 75737F108 60,603 883,046 SH   SOLE 0 883,046 0 0
Regeneron Pharmaceuticals COM 75886F107 29 60 SH   DFND 3 60 0 0
Relay Therapeutics Inc COM 75943R102 39 940 SH   DFND 1 940 0 0
Relay Therapeutics Inc COM 75943R102 2,031 48,873 SH   DFND 2 48,873 0 0
Relay Therapeutics Inc COM 75943R102 1,252 30,119 SH   DFND 3 30,119 0 0
ResMed COM 761152107 81,468 383,269 SH   DFND 1 383,269 0 0
ResMed COM 761152107 300,675 1,414,544 SH   DFND 2 1,314,964 0 99,580
ResMed COM 761152107 65,690 309,044 SH   DFND 3 147,334 0 161,710
ResMed COM 761152107 207,118 974,397 SH   SOLE 0 903,146 0 71,251
Research in Motion COM 09228F103 21 3,175 SH   DFND 3 3,175 0 0
Ringcentral Inc COM 76680R206 160 422 SH   DFND 3 422 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 35,160 505,538 SH   DFND 1 505,538 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 249,210 3,583,176 SH   DFND 2 3,200,257 0 382,919
Ritchie Bros Auctioneers (USA) COM 767744105 26,050 374,548 SH   DFND 3 166,967 0 207,581
Ritchie Bros Auctioneers (USA) COM 767744105 82,833 1,190,985 SH   SOLE 0 1,101,268 0 89,717
Ritchie Bros. Auctioneers COM 767744105 81,348 1,171,304 SH   DFND 2 641,812 0 529,492
Ritchie Bros. Auctioneers COM 767744105 30,136 433,928 SH   SOLE 0 433,928 0 0
Robert Half International Inc COM 770323103 8 135 SH   DFND 3 135 0 0
Roku COM CL A 77543R102 463,822 1,396,970 SH   DFND 1 1,396,970 0 0
Roku COM CL A 77543R102 451,543 1,359,986 SH   DFND 2 1,278,994 0 80,992
Roku COM CL A 77543R102 17,350 52,256 SH   DFND 3 52,256 0 0
Roku COM CL A 77543R102 107,426 323,554 SH   SOLE 0 323,554 0 0
Rollins Inc COM 775711104 23 583 SH   DFND 3 583 0 0
Royal Caribbean Cruises COM V7780T103 17,836 238,800 SH   DFND 1 238,800 0 0
Royal Caribbean Cruises COM V7780T103 986 13,200 SH   DFND 3 13,200 0 0
Rubius Therapeutics Inc COM 78116T103 6,732 887,000 SH   DFND 1 887,000 0 0
Rubius Therapeutics Inc COM 78116T103 1,255 165,310 SH   DFND 2 70,263 0 95,047
Rubius Therapeutics Inc COM 78116T103 593 78,186 SH   DFND 3 78,186 0 0
Rubius Therapeutics Inc COM 78116T103 27,169 3,579,565 SH   SOLE 0 3,579,565 0 0
Ryanair ADR SPONSORED ADR NE 783513203 35 320 SH   DFND 1 320 0 0
Ryanair ADR SPONSORED ADR NE 783513203 1,134,033 10,311,267 SH   DFND 2 8,734,250 0 1,577,017
Ryanair ADR SPONSORED ADR NE 783513203 10,758 97,822 SH   DFND 3 19,041 0 78,781
Ryanair ADR SPONSORED ADR NE 783513203 9,154 83,230 SH   SOLE 0 83,230 0 0
S&P Global Inc COM 78409V104 32,133 97,749 SH   DFND 1 97,749 0 0
S&P Global Inc COM 78409V104 130,236 396,179 SH   DFND 2 372,189 0 23,990
S&P Global Inc COM 78409V104 23,644 71,925 SH   DFND 3 32,239 0 39,686
S&P Global Inc COM 78409V104 76,138 231,614 SH   SOLE 0 214,341 0 17,273
SCP Pool Corporation COM 73278L105 34 90 SH   DFND 3 90 0 0
SEA Ltd ADR ADR 81141R100 453,879 2,280,226 SH   DFND 1 2,280,226 0 0
SEA Ltd ADR ADR 81141R100 729,583 3,665,323 SH   DFND 2 3,089,291 0 576,032
SEA Ltd ADR ADR 81141R100 123,379 619,837 SH   DFND 3 282,735 0 337,102
SEA Ltd ADR ADR 81141R100 458,726 2,304,578 SH   SOLE 0 2,161,181 0 143,397
SINA Corp ORD G81477104 5,575 131,550 SH   DFND 3 0 0 131,550
Sage Therapeutics Inc COM 78667J108 33 380 SH   DFND 1 380 0 0
Sage Therapeutics Inc COM 78667J108 1,771 20,467 SH   DFND 2 20,467 0 0
Sage Therapeutics Inc COM 78667J108 1,044 12,069 SH   DFND 3 12,069 0 0
Sailpoint Technologies Holding COM 78781P105 19 365 SH   DFND 3 365 0 0
Salesforce.com COM 79466L302 106,420 478,229 SH   DFND 1 478,229 0 0
Salesforce.com COM 79466L302 835,235 3,753,357 SH   DFND 2 1,236,979 0 2,516,378
Salesforce.com COM 79466L302 69,736 313,377 SH   DFND 3 245,134 0 68,243
Salesforce.com COM 79466L302 238,057 1,069,774 SH   SOLE 0 518,095 0 551,679
Sarepta Therapeutics Inc COM 803607100 30 178 SH   DFND 3 178 0 0
Schrodinger COM 80810D103 18 225 SH   DFND 3 225 0 0
Schweitzer-Maudit Int. COM 808541106 11 270 SH   DFND 3 270 0 0
Seagen Inc COM 81181C104 79,821 455,754 SH   DFND 1 455,754 0 0
Seagen Inc COM 81181C104 256,983 1,467,303 SH   DFND 2 1,319,622 0 147,681
Seagen Inc COM 81181C104 56,656 323,492 SH   DFND 3 160,921 0 162,571
Seagen Inc COM 81181C104 174,655 997,230 SH   SOLE 0 928,124 0 69,106
Service Corp.Intl. COM 817565104 68,156 1,388,106 SH   DFND 1 1,388,106 0 0
Service Corp.Intl. COM 817565104 246,075 5,011,715 SH   DFND 2 4,654,381 0 357,334
Service Corp.Intl. COM 817565104 51,891 1,056,847 SH   DFND 3 472,368 0 584,479
Service Corp.Intl. COM 817565104 165,763 3,376,024 SH   SOLE 0 3,123,559 0 252,465
Shake Shack Inc COM 819047101 14 163 SH   DFND 3 163 0 0
Sherwin-Williams Co COM 824348106 12,222 16,631 SH   DFND 2 16,631 0 0
ShockWave Medical Inc COM 82489T104 14,546 140,244 SH   DFND 1 140,244 0 0
ShockWave Medical Inc COM 82489T104 19,694 189,873 SH   DFND 2 106,569 0 83,304
ShockWave Medical Inc COM 82489T104 8,757 84,434 SH   DFND 3 84,434 0 0
ShockWave Medical Inc COM 82489T104 8,909 85,892 SH   SOLE 0 85,892 0 0
Shopify 'A' CL A 82509L107 1,272,391 1,124,070 SH   DFND 1 1,124,070 0 0
Shopify 'A' CL A 82509L107 3,560,672 3,145,609 SH   DFND 2 2,119,010 0 1,026,599
Shopify 'A' CL A 82509L107 335,646 296,520 SH   DFND 3 192,242 0 104,278
Shopify 'A' CL A 82509L107 1,311,409 1,158,540 SH   SOLE 0 956,122 0 202,418
Silicon Laboratories Inc COM 826919102 15 119 SH   DFND 3 119 0 0
Silicon Motion Technology ADR COM 82706C108 13,568 281,780 SH   DFND 1 281,780 0 0
Silicon Motion Technology ADR COM 82706C108 416 8,648 SH   DFND 2 0 0 8,648
Silicon Motion Technology ADR COM 82706C108 47 969 SH   DFND 3 969 0 0
Silicon Motion Technology ADR COM 82706C108 13,966 290,044 SH   SOLE 0 290,044 0 0
Silk Road Medical COM 82710M100 15 233 SH   DFND 3 233 0 0
SiteOne Landscape Supply COM 82982L103 77,739 490,064 SH   DFND 1 490,064 0 0
SiteOne Landscape Supply COM 82982L103 266,576 1,680,491 SH   DFND 2 1,560,514 0 119,977
SiteOne Landscape Supply COM 82982L103 57,165 360,365 SH   DFND 3 162,046 0 198,319
SiteOne Landscape Supply COM 82982L103 177,677 1,120,069 SH   SOLE 0 1,037,658 0 82,411
Six Flags Entertainment Corp COM 83001A102 20,501 601,200 SH   DFND 1 601,200 0 0
Six Flags Entertainment Corp COM 83001A102 1,146 33,600 SH   DFND 3 33,600 0 0
Slack Technologies Inc COM CL A 83088V102 134,478 3,183,664 SH   DFND 1 3,183,664 0 0
Slack Technologies Inc COM CL A 83088V102 150,237 3,556,743 SH   DFND 2 3,367,098 0 189,645
Slack Technologies Inc COM CL A 83088V102 8,950 211,888 SH   DFND 3 178,418 0 33,470
Slack Technologies Inc COM CL A 83088V102 32,757 775,508 SH   SOLE 0 775,508 0 0
Smartsheet COM 83200N103 23 326 SH   DFND 3 326 0 0
Snap Inc CL A 83304A106 103 2,060 SH   DFND 3 2,060 0 0
Snowflake Inc COM 833445109 58,199 206,820 SH   DFND 1 206,820 0 0
Snowflake Inc COM 833445109 102,629 364,708 SH   DFND 2 332,730 0 31,978
Snowflake Inc COM 833445109 14,690 52,203 SH   DFND 3 26,836 0 25,367
Snowflake Inc COM 833445109 104,166 370,170 SH   SOLE 0 358,577 0 11,593
Sohu.com COM 83410S108 3,190 200,140 SH   DFND 3 0 0 200,140
Solaredge Technologies Inc COM 83417M104 62 193 SH   DFND 3 193 0 0
Sorrento Therapeutics COM 83587F202 35 5,109 SH   DFND 3 5,109 0 0
Splunk Inc COM 848637104 17,149 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 25,081 147,632 SH   DFND 2 53,469 0 94,163
Splunk Inc COM 848637104 9,417 55,430 SH   DFND 3 55,430 0 0
Splunk Inc COM 848637104 12,552 73,884 SH   SOLE 0 73,884 0 0
Spotify Technology SA SHS L8681T102 408,018 1,296,694 SH   DFND 1 1,296,694 0 0
Spotify Technology SA SHS L8681T102 4,897,366 15,563,992 SH   DFND 2 10,756,824 0 4,807,168
Spotify Technology SA SHS L8681T102 144,207 458,296 SH   DFND 3 320,665 0 137,631
Spotify Technology SA SHS L8681T102 1,094,069 3,476,988 SH   SOLE 0 2,925,800 0 551,188
Sprout Social COM 85209W109 26 567 SH   DFND 3 567 0 0
Square Inc COM 852234103 251 1,153 SH   DFND 3 1,153 0 0
Staar Surgical COM PAR $0.01 852312305 79,676 1,005,758 SH   DFND 1 1,005,758 0 0
Staar Surgical COM PAR $0.01 852312305 49,114 619,965 SH   DFND 2 249,394 0 370,571
Staar Surgical COM PAR $0.01 852312305 23,847 301,021 SH   DFND 3 272,263 0 28,758
Staar Surgical COM PAR $0.01 852312305 33,283 420,133 SH   SOLE 0 420,133 0 0
Stamps.Com COM NEW 852857200 11 57 SH   DFND 3 57 0 0
Stanley Black & Decker COM 854502101 15 82 SH   DFND 3 82 0 0
Stericycle Inc COM 858912108 41,769 602,470 SH   DFND 1 602,470 0 0
Stericycle Inc COM 858912108 152,385 2,197,961 SH   DFND 2 2,042,003 0 155,958
Stericycle Inc COM 858912108 31,681 456,966 SH   DFND 3 204,902 0 252,064
Stericycle Inc COM 858912108 104,537 1,507,814 SH   SOLE 0 1,400,309 0 107,505
Stitch Fix COM CL A 860897107 139,837 2,381,423 SH   DFND 1 2,381,423 0 0
Stitch Fix COM CL A 860897107 128,019 2,180,158 SH   DFND 2 2,048,122 0 132,036
Stitch Fix COM CL A 860897107 5,369 91,435 SH   DFND 3 91,435 0 0
Stitch Fix COM CL A 860897107 32,805 558,670 SH   SOLE 0 558,670 0 0
StoneCo COM CL A G85158106 10,785 128,512 SH   DFND 2 128,512 0 0
Stratasys SHS M85548101 4,689 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 7,958 384,065 SH   DFND 2 137,015 0 247,050
Stratasys SHS M85548101 2,937 141,747 SH   DFND 3 141,747 0 0
Stratasys SHS M85548101 2,996 144,600 SH   SOLE 0 144,600 0 0
Stryker COM 863667101 13 55 SH   DFND 3 55 0 0
Summit Therapeutics New Listing COM 86627T108 860 183,027 SH   DFND 1 183,027 0 0
Summit Therapeutics New Listing COM 86627T108 889 189,234 SH   SOLE 0 189,234 0 0
Sunpower Corp COM 867652406 38 1,486 SH   DFND 3 1,486 0 0
SurveyMonkey COM 78489X103 26 1,028 SH   DFND 3 1,028 0 0
Sutro Biopharma COM 869367102 22,631 1,042,428 SH   DFND 1 1,042,428 0 0
Sutro Biopharma COM 869367102 14,182 653,226 SH   SOLE 0 653,226 0 0
Symantec Corp COM 668771108 10 480 SH   DFND 3 480 0 0
Synopsys COM 871607107 33 128 SH   DFND 3 128 0 0
T. Rowe Price COM 74144T108 12,869 85,006 SH   DFND 1 85,006 0 0
T. Rowe Price COM 74144T108 408 2,693 SH   DFND 2 0 0 2,693
T. Rowe Price COM 74144T108 44 290 SH   DFND 3 290 0 0
T. Rowe Price COM 74144T108 13,542 89,452 SH   SOLE 0 89,452 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 107,007 1,496,390 SH   DFND 1 1,496,390 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 2,525,654 35,318,890 SH   DFND 2 26,243,140 0 9,075,750
TAL Education Group ADR ADS REPSTG COM 874080104 68,105 952,388 SH   DFND 3 739,578 0 212,810
TAL Education Group ADR ADS REPSTG COM 874080104 238,835 3,339,879 SH   SOLE 0 1,613,308 0 1,726,571
TJX Companies COM 872540109 2,728 39,954 SH   DFND 1 39,954 0 0
TJX Companies COM 872540109 9,753 142,821 SH   DFND 2 142,821 0 0
TJX Companies COM 872540109 1,615 23,649 SH   DFND 3 15,086 0 8,563
TJX Companies COM 872540109 603 8,826 SH   SOLE 0 8,826 0 0
TSMC ADR SPONSORED ADR 874039100 52,874 484,907 SH   DFND 1 484,907 0 0
TSMC ADR SPONSORED ADR 874039100 773,873 7,097,146 SH   DFND 2 5,445,384 0 1,651,762
TSMC ADR SPONSORED ADR 874039100 2,068 18,962 SH   DFND 3 18,962 0 0
TSMC ADR SPONSORED ADR 874039100 145,070 1,330,429 SH   SOLE 0 1,154,561 0 175,868
Tabula Rasa HealthCare Inc COM 873379101 14,744 344,175 SH   DFND 1 344,175 0 0
Tabula Rasa HealthCare Inc COM 873379101 7,999 186,725 SH   DFND 2 67,234 0 119,491
Tabula Rasa HealthCare Inc COM 873379101 2,995 69,919 SH   DFND 3 69,919 0 0
Tabula Rasa HealthCare Inc COM 873379101 5,911 137,974 SH   SOLE 0 137,974 0 0
Tandem Diabetes Care COM NEW 875372203 14,055 146,892 SH   DFND 1 146,892 0 0
Tandem Diabetes Care COM NEW 875372203 17 176 SH   DFND 3 176 0 0
Tandem Diabetes Care COM NEW 875372203 14,197 148,377 SH   SOLE 0 148,377 0 0
Tata Motors Ltd ADR COM 876568502 51,541 4,090,544 SH   DFND 1 4,090,544 0 0
Tata Motors Ltd ADR COM 876568502 19,670 1,561,082 SH   DFND 2 1,561,082 0 0
Tata Motors Ltd ADR COM 876568502 270 21,442 SH   DFND 3 21,442 0 0
Tata Motors Ltd ADR COM 876568502 14,830 1,177,015 SH   SOLE 0 1,177,015 0 0
Teladoc COM 87918A105 425,542 2,128,136 SH   DFND 1 2,128,136 0 0
Teladoc COM 87918A105 586,790 2,934,535 SH   DFND 2 2,511,682 0 422,853
Teladoc COM 87918A105 149,216 746,228 SH   DFND 3 482,679 0 263,549
Teladoc COM 87918A105 285,896 1,429,768 SH   SOLE 0 1,350,490 0 79,278
Teledyne Technologies Inc COM 879360105 14 35 SH   DFND 3 35 0 0
Telus Corp COM 87971M103 8 399 SH   DFND 3 399 0 0
Tenable Holdings COM 88025T102 17 328 SH   DFND 3 328 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 65,119 3,384,589 SH   DFND 1 3,384,589 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 559,840 29,097,732 SH   DFND 2 21,467,504 0 7,630,228
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 37,056 1,925,981 SH   DFND 3 861,309 0 1,064,672
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 156,693 8,144,146 SH   SOLE 0 7,683,662 0 460,484
Teradyne COM 880770102 101,161 843,782 SH   DFND 1 843,782 0 0
Teradyne COM 880770102 537,062 4,479,627 SH   DFND 2 4,266,332 0 213,295
Teradyne COM 880770102 74,365 620,275 SH   DFND 3 277,373 0 342,902
Teradyne COM 880770102 235,298 1,962,619 SH   SOLE 0 1,813,924 0 148,695
Tesla Inc COM 88160R101 2,222,332 3,149,251 SH   DFND 1 3,149,251 0 0
Tesla Inc COM 88160R101 11,835,859 16,772,513 SH   DFND 2 11,550,598 0 5,221,915
Tesla Inc COM 88160R101 826,793 1,171,643 SH   DFND 3 827,680 0 343,963
Tesla Inc COM 88160R101 4,382,749 6,210,763 SH   SOLE 0 5,180,850 0 1,029,913
Texas Roadhouse Inc COM 882681109 11 137 SH   DFND 3 137 0 0
The Trade Desk COM CL A 88339J105 771,409 963,057 SH   DFND 1 963,057 0 0
The Trade Desk COM CL A 88339J105 1,023,603 1,277,906 SH   DFND 2 1,197,165 0 80,741
The Trade Desk COM CL A 88339J105 118,414 147,833 SH   DFND 3 85,441 0 62,392
The Trade Desk COM CL A 88339J105 419,386 523,578 SH   SOLE 0 498,779 0 24,799
Thermo Fisher Scientific COM 883556102 126,886 272,416 SH   DFND 1 272,416 0 0
Thermo Fisher Scientific COM 883556102 486,141 1,043,713 SH   DFND 2 974,044 0 69,669
Thermo Fisher Scientific COM 883556102 96,145 206,418 SH   DFND 3 91,871 0 114,547
Thermo Fisher Scientific COM 883556102 306,966 659,036 SH   SOLE 0 611,152 0 47,884
Thor Industries Inc COM 885160101 11 118 SH   DFND 3 118 0 0
Trimble Navigation COM 896239100 23 346 SH   DFND 3 346 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 8,329 246,939 SH   DFND 1 246,939 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 207,753 6,159,294 SH   DFND 2 4,525,807 0 1,633,487
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 34,108 1,011,196 SH   DFND 3 75,128 0 936,068
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 1,541 45,692 SH   DFND 4 45,692 0 0
Truecar Inc COM 89785L107 1 351 SH   DFND 3 351 0 0
Trupanion COM 898202106 23,655 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 43,937 367,027 SH   DFND 2 132,906 0 234,121
Trupanion COM 898202106 16,711 139,596 SH   DFND 3 139,596 0 0
Trupanion COM 898202106 87,987 735,000 SH   SOLE 0 735,000 0 0
Twilio Inc CL A 90138F102 287,300 848,743 SH   DFND 1 848,743 0 0
Twilio Inc CL A 90138F102 483,034 1,426,985 SH   DFND 2 1,319,595 0 107,390
Twilio Inc CL A 90138F102 53,605 158,360 SH   DFND 3 88,207 0 70,153
Twilio Inc CL A 90138F102 188,878 557,984 SH   SOLE 0 529,382 0 28,602
Ultragenyx COM 90400D108 15 106 SH   DFND 3 106 0 0
United Parcel Service CL B 911312106 41,747 247,902 SH   DFND 1 247,902 0 0
United Parcel Service CL B 911312106 1,484 8,812 SH   DFND 2 0 0 8,812
United Parcel Service CL B 911312106 141 840 SH   DFND 3 840 0 0
United Parcel Service CL B 911312106 42,644 253,231 SH   SOLE 0 253,231 0 0
Unity Biotechnology Inc COM 91381U101 1,300 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 18,628 3,555,014 SH   SOLE 0 3,555,014 0 0
Upwork Inc COM 91688F104 62,342 1,805,959 SH   DFND 1 1,805,959 0 0
Upwork Inc COM 91688F104 39,379 1,140,761 SH   DFND 2 473,578 0 667,183
Upwork Inc COM 91688F104 20,369 590,073 SH   DFND 3 523,240 0 66,833
Upwork Inc COM 91688F104 32,130 930,768 SH   SOLE 0 930,768 0 0
Uxin ADR ADS 91818X108 1,057 1,211,500 SH   DFND 1 1,211,500 0 0
Uxin ADR ADS 91818X108 493 564,600 SH   SOLE 0 564,600 0 0
Vale SA ADR ADR 91912E105 48,634 2,901,781 SH   DFND 1 2,901,781 0 0
Vale SA ADR ADR 91912E105 349,799 20,871,087 SH   DFND 2 10,104,451 0 10,766,636
Varonis Systems Inc COM 922280102 34 205 SH   DFND 3 205 0 0
Vedanta Ltd ADR COM 92242Y100 3,793 431,984 SH   SOLE 0 431,984 0 0
Veeco Instruments COM 922417100 10,188 586,854 SH   DFND 1 586,854 0 0
Veeco Instruments COM 922417100 9,364 539,428 SH   DFND 2 193,848 0 345,580
Veeco Instruments COM 922417100 3,601 207,418 SH   DFND 3 207,418 0 0
Veeva Systems Inc Class A COM 922475108 45 165 SH   DFND 1 165 0 0
Veeva Systems Inc Class A COM 922475108 2,350 8,633 SH   DFND 2 8,633 0 0
Veeva Systems Inc Class A COM 922475108 1,423 5,226 SH   DFND 3 5,226 0 0
Verint Systems Inc COM 92343X100 25 369 SH   DFND 3 369 0 0
Verisk Analytics COM 92345Y106 11,941 57,521 SH   DFND 2 57,521 0 0
ViewRay COM 92672L107 3 803 SH   DFND 3 803 0 0
Vir Biotechnology Inc COM 92764N102 20 741 SH   DFND 1 741 0 0
Vir Biotechnology Inc COM 92764N102 1,008 37,626 SH   DFND 2 37,626 0 0
Vir Biotechnology Inc COM 92764N102 593 22,144 SH   DFND 3 22,144 0 0
Vir Biotechnology Inc COM 92764N102 98,669 3,684,437 SH   SOLE 0 3,684,437 0 0
Visa Inc-Class A Shares COM CL A 92826C839 15,822 72,337 SH   DFND 2 72,337 0 0
Vontier COM 928881101 1,529 45,779 SH   DFND 2 45,779 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 2,552 571,000 SH   DFND 1 571,000 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 2,410 539,210 SH   DFND 3 539,210 0 0
Vroom Inc COM 92918V109 161,890 3,951,427 SH   DFND 1 3,951,427 0 0
Vroom Inc COM 92918V109 197,387 4,817,842 SH   DFND 2 4,530,869 0 286,973
Vroom Inc COM 92918V109 6,183 150,908 SH   DFND 3 150,908 0 0
Vroom Inc COM 92918V109 38,870 948,745 SH   SOLE 0 948,745 0 0
Vyne Therapeutics Inc COM 92941V100 308 194,824 SH   DFND 1 194,824 0 0
Vyne Therapeutics Inc COM 92941V100 316 200,225 SH   SOLE 0 200,225 0 0
WD-40 Co COM 929236107 16 60 SH   DFND 3 60 0 0
WEC Energy Group COM 92939U106 1,221 13,262 SH   DFND 1 13,262 0 0
Wabtec COM 929740108 34,909 476,896 SH   DFND 1 476,896 0 0
Wabtec COM 929740108 130,441 1,781,982 SH   DFND 2 1,662,146 0 119,836
Wabtec COM 929740108 25,959 354,625 SH   DFND 3 160,728 0 193,897
Wabtec COM 929740108 81,003 1,106,601 SH   SOLE 0 1,021,753 0 84,848
Wal-Mart Stores COM 931142103 16 108 SH   DFND 3 108 0 0
Waters COM 941848103 4,779 19,314 SH   DFND 1 19,314 0 0
Waters COM 941848103 14,404 58,216 SH   DFND 2 58,216 0 0
Waters COM 941848103 2,793 11,290 SH   DFND 3 7,266 0 4,024
Waters COM 941848103 1,057 4,271 SH   SOLE 0 4,271 0 0
Watsco Inc COM 942622200 169,381 747,652 SH   DFND 1 747,652 0 0
Watsco Inc COM 942622200 158,559 699,885 SH   DFND 2 661,646 0 38,239
Watsco Inc COM 942622200 9,800 43,259 SH   DFND 3 36,084 0 7,175
Watsco Inc COM 942622200 56,528 249,516 SH   SOLE 0 249,516 0 0
Wayfair Inc Class A CL A 94419L101 574,753 2,545,296 SH   DFND 1 2,545,296 0 0
Wayfair Inc Class A CL A 94419L101 637,257 2,822,093 SH   DFND 2 2,570,717 0 251,376
Wayfair Inc Class A CL A 94419L101 66,488 294,443 SH   DFND 3 214,038 0 80,405
Wayfair Inc Class A CL A 94419L101 457,016 2,023,895 SH   SOLE 0 1,994,154 0 29,741
Wheaton Precious Metals COM 962879102 341 8,165 SH   DFND 1 8,165 0 0
Williams-Sonoma Inc COM 969904101 7 68 SH   DFND 3 68 0 0
Wix Com SHS M98068105 821,046 3,284,710 SH   DFND 2 1,842,908 0 1,441,802
Wix Com SHS M98068105 117 467 SH   DFND 3 467 0 0
Workday Inc CL A 98138H101 327,317 1,366,041 SH   DFND 1 1,366,041 0 0
Workday Inc CL A 98138H101 1,078,174 4,499,703 SH   DFND 2 2,041,645 0 2,458,058
Workday Inc CL A 98138H101 87,407 364,790 SH   DFND 3 286,260 0 78,530
Workday Inc CL A 98138H101 497,912 2,078,010 SH   SOLE 0 1,551,094 0 526,916
XPEL COM 98379L100 17 326 SH   DFND 3 326 0 0
Xencor Inc COM 98401F105 20 449 SH   DFND 3 449 0 0
Xperi Holding Corp COM 98390M103 42 2,015 SH   DFND 3 2,015 0 0
Xylem COM 98419M100 67,040 658,610 SH   DFND 1 658,610 0 0
Xylem COM 98419M100 12,950 127,225 SH   DFND 2 77,859 0 49,366
Xylem COM 98419M100 35,465 348,411 SH   DFND 3 221,847 0 126,564
Yandex SHS CLASS A N97284108 14,293 205,414 SH   DFND 2 0 0 205,414
Yatsen Holding Ltd ADR COM 985194109 21,360 1,256,485 SH   DFND 1 1,256,485 0 0
Yatsen Holding Ltd ADR COM 985194109 58,739 3,455,219 SH   DFND 2 1,689,784 0 1,765,435
Yelp COM 985817105 8 251 SH   DFND 3 251 0 0
Yext Inc COM 98585N106 75,451 4,799,673 SH   DFND 1 4,799,673 0 0
Yext Inc COM 98585N106 69,102 4,395,832 SH   DFND 2 3,284,929 0 1,110,903
Yext Inc COM 98585N106 11,810 751,265 SH   DFND 3 722,490 0 28,775
Yext Inc COM 98585N106 25,048 1,593,354 SH   SOLE 0 1,593,354 0 0
Zai Lab ADR ADR 98887Q104 172,313 1,273,189 SH   DFND 1 1,273,189 0 0
Zai Lab ADR ADR 98887Q104 252,442 1,865,241 SH   DFND 2 876,549 0 988,692
Zai Lab ADR ADR 98887Q104 48,305 356,919 SH   DFND 3 172,419 0 184,500
Zai Lab ADR ADR 98887Q104 48,019 354,800 SH   SOLE 0 354,800 0 0
Zillow Group Inc Class A CL A 98954M101 154,355 1,135,463 SH   DFND 1 1,135,463 0 0
Zillow Group Inc Class A CL A 98954M101 215,434 1,584,776 SH   DFND 2 1,406,868 0 177,908
Zillow Group Inc Class A CL A 98954M101 14,624 107,577 SH   DFND 3 107,577 0 0
Zillow Group Inc Class A CL A 98954M101 47,803 351,650 SH   SOLE 0 351,650 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 190,896 1,470,692 SH   DFND 1 1,470,692 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 421,527 3,247,509 SH   DFND 2 2,530,130 0 717,379
Zillow Group Inc Class C CL C CAP STK 98954M200 103,918 800,602 SH   DFND 3 503,950 0 296,652
Zillow Group Inc Class C CL C CAP STK 98954M200 288,982 2,226,363 SH   SOLE 0 2,098,719 0 127,644
Zoom Video Communications Inc CL A 98980L101 411,543 1,220,037 SH   DFND 1 1,220,037 0 0
Zoom Video Communications Inc CL A 98980L101 1,113,659 3,301,492 SH   DFND 2 1,538,304 0 1,763,188
Zoom Video Communications Inc CL A 98980L101 90,389 267,962 SH   DFND 3 213,198 0 54,764
Zoom Video Communications Inc CL A 98980L101 612,415 1,815,530 SH   SOLE 0 1,431,964 0 383,566
Zuora Inc Class A COM CL A 98983V106 19,693 1,413,711 SH   DFND 1 1,413,711 0 0
Zuora Inc Class A COM CL A 98983V106 10,415 747,699 SH   DFND 2 272,015 0 475,684
Zuora Inc Class A COM CL A 98983V106 3,964 284,542 SH   DFND 3 284,542 0 0
Zuora Inc Class A COM CL A 98983V106 8,030 576,468 SH   SOLE 0 576,468 0 0
Zynex COM 98986M103 6 437 SH   DFND 3 437 0 0
Zynga Inc COM 98986T108 32 3,281 SH   DFND 3 3,281 0 0
iQIYI Inc ADR SPON ADR 46267X108 23,748 1,358,567 SH   DFND 1 1,358,567 0 0
iQIYI Inc ADR SPON ADR 46267X108 4,586 262,352 SH   DFND 2 262,352 0 0
iQIYI Inc ADR SPON ADR 46267X108 86 4,896 SH   DFND 3 4,896 0 0
iQIYI Inc ADR SPON ADR 46267X108 3,207 183,441 SH   SOLE 0 183,441 0 0
iRobot COM 462726100 15,386 191,634 SH   DFND 1 191,634 0 0
iRobot COM 462726100 19,094 237,809 SH   DFND 2 96,668 0 141,141
iRobot COM 462726100 9,579 119,301 SH   DFND 3 106,548 0 12,753
iRobot COM 462726100 24,691 307,517 SH   SOLE 0 307,517 0 0
iShares Physical Silver ETC COM 46428Q109 60,344 2,372,000 SH   DFND 1 2,372,000 0 0
iShares Physical Silver ETC COM 46428Q109 3,432 134,900 SH   DFND 3 134,900 0 0
j2 Global COM 48123V102 8 77 SH   DFND 3 77 0 0
nLIGHT COM 65487K100 17 516 SH   DFND 3 516 0 0