The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 7,936 279,844 SH   SOLE   279,844 0 0
ACCOLADE INC COM 00437E102 11,394 293,138 SH   SOLE   293,138 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 3,192 400,000 SH   SOLE   400,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 40,363 830,000 SH   SOLE   830,000 0 0
ADMA BIOLOGICS INC COM 000899104 39,638 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 48,397 15,919,925 SH   SOLE   15,919,925 0 0
AKERO THERAPEUTICS INC COM 00973Y108 675 21,938 SH   SOLE   21,938 0 0
ALBIREO PHARMA INC COM 01345P106 78,758 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 46,575 6,285,458 SH   SOLE   6,285,458 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 43,132 1,143,790 SH   SOLE   1,143,790 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 3,729 561,574 SH   SOLE   561,574 0 0
AMERICAN WELL CORP CL A 03044L105 13,486 455,000 SH   SOLE   455,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 354,723 25,122,048 SH   SOLE   25,122,048 0 0
AMYRIS INC COM NEW 03236M200 8,568 3,333,332 SH   SOLE   3,333,332 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 8,496 1,750,000 SH   SOLE   1,750,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 46,753 625,129 SH   SOLE   625,129 0 0
ATHENEX INC COM 04685N103 161,323 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 57,499 3,114,805 SH   SOLE   3,114,805 0 0
ATRICURE INC COM 04963C209 8,636 216,449 SH   SOLE   216,449 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 34,788 1,235,818 SH   SOLE   1,235,818 0 0
BCTG ACQUISITION CORP COM 05492W103 5,180 500,000 SH   SOLE   500,000 0 0
BIO RAD LABS INC CL A 090572207 252 489 SH   SOLE   489 0 0
BIOGEN INC COM 09062X103 28,368 100,000 SH Call SOLE   100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 61,606 664,574 SH   SOLE   664,574 0 0
BRIDGEBIO PHARMA INC COM 10806X102 251,619 6,706,268 SH   SOLE   6,706,268 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 3,762 150,000 SH   SOLE   150,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 738 49,751 SH   SOLE   49,751 0 0
COHERUS BIOSCIENCES INC COM 19249H103 66,693 3,636,485 SH   SOLE   3,636,485 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 42,849 2,058,068 SH   SOLE   2,058,068 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 163,765 17,500,000 PRN   SOLE   17,500,000 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 36,554 1,047,404 SH   SOLE   1,047,404 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 21,119 2,150,641 SH   SOLE   2,150,641 0 0
COVETRUS INC COM 22304C100 636 26,075 SH   SOLE   26,075 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 57,342 3,659,381 SH   SOLE   3,659,381 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 112,187 1,341,308 SH   SOLE   1,341,308 0 0
CYTOKINETICS INC NOTE 4.000%11/1 23282WAA8 218,301 9,770,000 PRN   SOLE   9,770,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 17,137 2,577,043 SH   SOLE   2,577,043 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 11,776 6,806,975 SH   SOLE   6,806,975 0 0
DEERFIELD HEALTHCARE TECH AC UNIT 07/16/2025 244413209 3,189 300,000 SH   SOLE   300,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 14,392 800,000 SH   SOLE   800,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 8,076 400,000 SH   SOLE   400,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 34,710 686,922 SH   SOLE   686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,138 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 12,575 678,633 SH   SOLE   678,633 0 0
FERRARI N V COM N3167Y103 1,141 6,200 SH   SOLE   6,200 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 62,300 1,250,000 SH   SOLE   1,250,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 62,558 3,256,518 SH   SOLE   3,256,518 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 26,877 2,235,983 SH   SOLE   2,235,983 0 0
GALERA THERAPEUTICS INC COM 36338D108 2,938 325,000 SH   SOLE   325,000 0 0
GERON CORP COM 374163103 23,423 13,461,538 SH   SOLE   13,461,538 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 319,867 5,800,996 SH   SOLE   5,800,996 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 14,759 435,377 SH   SOLE   435,377 0 0
HEALTH CATALYST INC COM 42225T107 10,654 291,084 SH   SOLE   291,084 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 4,950 450,000 SH   SOLE   450,000 0 0
HOLOGIC INC COM 436440101 11,300 170,000 SH   SOLE   170,000 0 0
IMMATICS N.V SHS N44445109 26,525 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNOMEDICS INC COM 452907108 77,559 912,140 SH   SOLE   912,140 0 0
IMMUNOVANT INC COM 45258J102 49,266 1,400,000 SH   SOLE   1,400,000 0 0
INARI MED INC COM 45332Y109 58,563 848,500 SH   SOLE   848,500 0 0
INSULET CORP COM 45784P101 8,927 37,733 SH   SOLE   37,733 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 332,019 10,085,632 SH   SOLE   10,085,632 0 0
IVERIC BIO INC COM 46583P102 19,635 3,481,431 SH   SOLE   3,481,431 0 0
KADMON HLDGS INC COM 48283N106 61,588 15,711,334 SH   SOLE   15,711,334 0 0
KODIAK SCIENCES INC COM 50015M109 61,757 1,043,021 SH   SOLE   1,043,021 0 0
LEAP THERAPEUTICS INC COM 52187K101 16,783 8,476,496 SH   SOLE   8,476,496 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 772 25,000 SH   SOLE   25,000 0 0
LIFESCI ACQUISITION CORP UNIT 03/31/2025 53228P208 4,080 300,000 SH   SOLE   300,000 0 0
LIVONGO HEALTH INC COM 539183103 1,493 10,663 SH   SOLE   10,663 0 0
LONGVIEW ACQUISITION CORP UNIT 99/99/9999 543195200 7,105 700,000 SH   SOLE   700,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 36,028 3,222,561 SH   SOLE   3,222,561 0 0
MACROGENICS INC COM 556099109 32,525 1,291,181 SH   SOLE   1,291,181 0 0
MEIRAGTX HLDGS PLC COM G59665102 85,176 6,433,277 SH   SOLE   6,433,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105 570,477 3,435,575 SH   SOLE   3,435,575 0 0
MOLECULAR TEMPLATES INC COM 608550109 27,018 2,474,133 SH   SOLE   2,474,133 0 0
MORPHIC HLDG INC COM 61775R105 13,314 487,000 SH   SOLE   487,000 0 0
MOTUS GI HLDGS INC COM 62014P108 4,027 4,210,542 SH   SOLE   4,210,542 0 0
MYLAN N.V SHS EURO N59465109 14,895 1,004,419 SH   SOLE   1,004,419 0 0
MYOKARDIA INC COM 62857M105 190,183 1,395,017 SH   SOLE   1,395,017 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 41,012 19,436,906 SH   SOLE   19,436,906 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 148,924 1,548,715 SH   SOLE   1,548,715 0 0
NEVRO CORP COM 64157F103 115,085 826,164 SH   SOLE   826,164 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 141,822 9,000,000 PRN   SOLE   9,000,000 0 0
NOVAVAX INC COM NEW 670002401 76,681 707,715 SH   SOLE   707,715 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 54 420,875 SH   SOLE   420,875 0 0
OUTSET MED INC COM 690145107 142,391 2,847,822 SH   SOLE   2,847,822 0 0
PERSONALIS INC COM 71535D106 591 27,272 SH   SOLE   27,272 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 21,497 605,556 SH   SOLE   605,556 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 6,987 787,745 SH   SOLE   787,745 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 10,242 608,544 SH   SOLE   608,544 0 0
PROVENTION BIO INC COM 74374N102 54,729 4,265,711 SH   SOLE   4,265,711 0 0
QUOTIENT LTD SHS G73268107 83,272 16,200,818 SH   SOLE   16,200,818 0 0
REGENERON PHARMACEUTICALS COM 75886F107 2,799 5,000 SH   SOLE   5,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 99,209 2,329,407 SH   SOLE   2,329,407 0 0
REPLIMUNE GROUP INC COM 76029N106 443 19,230 SH   SOLE   19,230 0 0
RETROPHIN INC COM 761299106 59,812 3,240,112 SH   SOLE   3,240,112 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 390,119 45,000,000 PRN   SOLE   45,000,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 7,803 224,224 SH   SOLE   224,224 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 50,041 2,189,010 SH   SOLE   2,189,010 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,600 1,000,000 SH   SOLE   1,000,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 711 66,655 SH   SOLE   66,655 0 0
SILK RD MED INC COM 82710M100 34,956 520,100 SH   SOLE   520,100 0 0
SOLID BIOSCIENCES INC COM 83422E105 13,702 6,749,803 SH   SOLE   6,749,803 0 0
SPDR SER TR S&P BIOTECH 78464A870 22,286 200,000 SH Put SOLE   200,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 165,946 3,481,148 SH   SOLE   3,481,148 0 0
STOKE THERAPEUTICS INC COM 86150R107 22,505 671,978 SH   SOLE   671,978 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 10,538 470,440 SH   SOLE   470,440 0 0
TCR2 THERAPEUTICS INC COM 87808K106 8,128 400,000 SH   SOLE   400,000 0 0
TG THERAPEUTICS INC COM 88322Q108 907 33,893 SH   SOLE   33,893 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 21,570 1,500,000 SH   SOLE   1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 4,290 315,237 SH   SOLE   315,237 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1,630 114,674 SH   SOLE   114,674 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 28,819 329,890 SH   SOLE   329,890 0 0
TWIST BIOSCIENCE CORP COM 90184D100 8,566 112,756 SH   SOLE   112,756 0 0
UNUM THERAPEUTICS INC COM 903214104 18,615 7,955,000 SH   SOLE   7,955,000 0 0
UROVANT SCIENCES LTD SHS G9381B108 22,106 2,366,831 SH   SOLE   2,366,831 0 0
VANECK VECTORS ETF TR PHARMACEUTICAL 92189F692 12,434 200,000 SH Put SOLE   200,000 0 0
VAXCYTE INC COM 92243G108 41,973 850,000 SH   SOLE   850,000 0 0
VBI VACCINES INC COM NEW 91822J103 157,421 55,042,465 SH   SOLE   55,042,465 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 18,027 2,888,889 SH   SOLE   2,888,889 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 26,397 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 4,323 1,650,000 SH   SOLE   1,650,000 0 0
VIEWRAY INC COM 92672L107 8,581 2,451,748 SH   SOLE   2,451,748 0 0
VYNE THERAPEUTICS INC COM NEW 92941V100 37,975 22,876,410 SH   SOLE   22,876,410 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 21,225 2,500,000 SH   SOLE   2,500,000 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 34,325 1,050,003 SH   SOLE   1,050,003 0 0
ZYMEWORKS INC COM 98985W102 204,999 4,400,999 SH   SOLE   4,400,999 0 0