The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 56,265 500,000 SH   DFND 1 500,000 0 0
AGENUS INC COM NEW 00847G705 34,000 8,500,000 SH   DFND 1 8,500,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 26,466 859,550 SH   DFND 1 859,550 0 0
AKOUOS INC COM 00973J101 11,206 499,991 SH   DFND 1 499,991 0 0
ALBIREO PHARMA INC COM 01345P106 23,359 700,000 SH   DFND 1 700,000 0 0
ALLAKOS INC COM 01671P100 6,109 75,000 SH   DFND 1 75,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 35,959 971,770 SH   DFND 1 971,770 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 1,263 300,000 SH   DFND 1 300,000 0 0
ANAPTYSBIO INC COM 032724106 9,588 650,000 SH   DFND 1 650,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 56,300 1,866,108 SH   DFND 1 1,866,108 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 30,030 700,000 SH   DFND 1 700,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 2,244 30,000 SH   DFND 1 30,000 0 0
ARGENX SE SPONSORED ADR 04016X101 10,501 40,000 SH   DFND 1 40,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 19,290 125,000 SH   DFND 1 125,000 0 0
ATRECA INC CL A COM 04965G109 4,100 293,500 SH   DFND 1 293,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 4,914 422,167 SH   DFND 1 422,167 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 5,940 1,000,000 SH   DFND 1 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 69,538 2,514,546 SH   DFND 1 2,514,546 0 0
AVROBIO INC COM 05455M100 3,177 244,032 SH   DFND 1 244,032 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 35,371 693,000 SH   DFND 1 693,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 17,813 250,000 SH   DFND 1 250,000 0 0
BCTG ACQUISITION CORP COM 05492W103 8,365 800,000 SH   DFND 1 800,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 19,608 796,428 SH   DFND 1 796,428 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 32,505 500,000 SH   DFND 1 500,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 22,410 325,000 SH   DFND 1 325,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 25,493 275,000 SH   DFND 1 275,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 85,011 2,265,762 SH   DFND 1 2,265,762 0 0
CABALETTA BIO INC COM 12674W109 22,410 2,067,302 SH   DFND 1 2,067,302 0 0
CARDIFF ONCOLOGY INC COM 14147L108 2,483 175,000 SH   DFND 1 175,000 0 0
CHEMOCENTRYX INC COM 16383L106 76,720 1,400,000 SH   DFND 1 1,400,000 0 0
CHEMOCENTRYX INC COM 16383L106 13,700 250,000 SH Call DFND 1 2,500 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 25,092 300,000 SH   DFND 1 300,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 12,825 250,000 SH   DFND 1 250,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 50,186 993,185 SH   DFND 1 993,185 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 3,659 449,510 SH   DFND 1 449,510 0 0
FATE THERAPEUTICS INC COM 31189P102 600 15,000 SH   DFND 1 15,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 166,465 3,379,373 SH   DFND 1 3,379,373 0 0
FS DEV CORP COM CL A 303020101 5,599 500,000 SH   DFND 1 500,000 0 0
GALAPAGOS NV SPON ADR 36315X101 18,471 130,000 SH   DFND 1 130,000 0 0
GENETRON HLDGS LTD ADS 37186H100 5,970 500,000 SH   DFND 1 500,000 0 0
GOSSAMER BIO INC COM 38341P102 3,082 248,382 SH   DFND 1 248,382 0 0
HARPOON THERAPEUTICS INC COM 41358P106 9,694 570,600 SH   DFND 1 570,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 8,800 800,000 SH   DFND 1 800,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 5,039 470,897 SH   DFND 1 470,897 0 0
IGM BIOSCIENCES INC COM 449585108 16,607 225,000 SH   DFND 1 225,000 0 0
IMMUNOVANT INC COM 45258J102 57,639 1,637,951 SH   DFND 1 1,637,951 0 0
INSMED INC COM PAR $.01 457669307 11,249 350,000 SH   DFND 1 350,000 0 0
INSPIRE MED SYS INC COM 457730109 15,486 120,000 SH   DFND 1 120,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 8,635 350,000 SH   DFND 1 350,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 74,895 500,000 SH Put DFND 1 5,000 0 0
KADMON HOLDINGS INC COM 48283N106 3,920 1,000,000 SH   DFND 1 1,000,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 4,510 931,800 SH   DFND 1 931,800 0 0
KURA ONCOLOGY INC COM 50127T109 15,320 500,000 SH   DFND 1 500,000 0 0
MERUS N V COM N5749R100 5,151 429,284 SH   DFND 1 429,284 0 0
MINERVA NEUROSCIENCES INC COM 603380106 759 238,817 SH   DFND 1 238,817 0 0
MIRATI THERAPEUTICS INC COM 60468T105 45,664 275,000 SH   DFND 1 275,000 0 0
MORPHIC HLDG INC COM 61775R105 6,835 250,000 SH   DFND 1 250,000 0 0
MYOKARDIA INC COM 62857M105 61,349 450,000 SH   DFND 1 450,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 29,996 2,134,966 SH   DFND 1 2,134,966 0 0
NEKTAR THERAPEUTICS COM 640268108 830 50,000 SH   DFND 1 50,000 0 0
OMEROS CORP COM 682143102 50,525 5,000,000 SH   DFND 1 5,000,000 0 0
OMEROS CORP COM 682143102 10,110 1,000,000 SH Call DFND 1 10,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,055 256,649 SH   DFND 1 256,649 0 0
OTONOMY INC COM 68906L105 13,129 3,241,800 SH   DFND 1 3,241,800 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 54 416,666 SH   DFND 1 416,666 0 0
PANACEA ACQUISITION CORP UNIT 99/99/9999 698102209 3,000 250,000 SH   DFND 1 250,000 0 0
PLIANT THERAPEUTICS, INC COM 729139105 13,571 611,409 SH   DFND 1 611,409 0 0
PRECISION BIOSCIENCES INC COM 74019P108 2,135 346,524 SH   DFND 1 346,524 0 0
PROTARA THERAPEUTIC INC COM STK 74365U107 7,574 450,000 SH   DFND 1 450,000 0 0
QUOTIENT LTD SHS G73268107 10,280 2,000,000 SH   DFND 1 2,000,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 43,839 450,000 SH   DFND 1 450,000 0 0
REPARE THERAPEUTICS INC COM 760273102 10,725 348,567 SH   DFND 1 348,567 0 0
REVOLUTION MEDICINES INC COM 76155X100 91,878 2,640,177 SH   DFND 1 2,640,177 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 31,285 1,368,550 SH   DFND 1 1,368,550 0 0
SAREPTA THERAPEUTICS INC(NSM) COM 803607100 11,937 85,000 SH   DFND 1 85,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 66,900 6,000,000 SH   DFND 1 6,000,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 5,575 500,000 SH Call DFND 1 5,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 167,445 500,000 SH Put DFND 1 5,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 51,501 1,537,807 SH   DFND 1 1,537,807 0 0
TCR2 THERAPEUTICS INC COM 87808K106 12,192 600,000 SH   DFND 1 600,000 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 7,190 500,000 SH   DFND 1 500,000 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 9,611 650,072 SH   DFND 1 650,072 0 0
TRICIDA INC COM 89610F101 6,595 727,975 SH   DFND 1 727,975 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 35,525 2,500,000 SH   DFND 1 2,500,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 213,359 2,442,297 SH   DFND 1 2,442,297 0 0
TWIST BIOSCIENCE CORP COM 90184D100 37,985 500,000 SH   DFND 1 500,000 0 0
UNIQURE NV SHS N90064101 11,970 325,000 SH   DFND 1 325,000 0 0
VESPER HEALTHCARE ACQSTN COR UNIT 99/99/9999 92538T203 4,104 400,000 SH   DFND 1 400,000 0 0
VIELA BIO INC COM 926613100 44,507 1,585,000 SH   DFND 1 1,585,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 55,715 500,000 SH Put DFND 1 5,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 53,658 1,397,700 SH   DFND 1 1,397,700 0 0
ZAI LAB LTD ADR 98887Q104 15,727 189,092 SH   DFND 1 189,092 0 0
ZYMEWORKS INC COM 98985W102 53,567 1,150,000 SH   DFND 1 1,150,000 0 0