The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 | 43,948 | 501,750 | SH | DFND | 0 | 501,750 | 0 | ||
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 17,370 | 421,087 | SH | DFND | 0 | 421,087 | 0 | ||
| ACORDA THERAPEUTICS INC | NOTE 1.750% 6/1 | 00484MAA4 | 1,200 | 2,000,000 | PRN | DFND | 0 | 2,000,000 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 6,779 | 849,440 | SH | DFND | 0 | 849,440 | 0 | ||
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 26,219 | 2,227,611 | SH | DFND | 0 | 2,227,611 | 0 | ||
| AERIE PHARMACEUTICALS INC | NOTE 1.500%10/0 | 00771VAB4 | 41,948 | 51,850,000 | PRN | DFND | 0 | 51,850,000 | 0 | ||
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 80,538 | 703,817 | SH | DFND | 0 | 703,817 | 0 | ||
| ALLENA PHARMACEUTICALS INC | COM | 018119107 | 421 | 284,285 | SH | DFND | 1 | 0 | 284,285 | 0 | |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 8,457 | 224,266 | SH | DFND | 0 | 224,266 | 0 | ||
| AMAZON COM INC | COM | 023135106 | 16,821 | 5,342 | SH | DFND | 0 | 5,342 | 0 | ||
| AMERICAN WELL CORP | CL A | 03044L105 | 3,853 | 130,000 | SH | DFND | 0 | 130,000 | 0 | ||
| ANTHEM INC | COM | 036752103 | 27,787 | 103,455 | SH | DFND | 0 | 103,455 | 0 | ||
| APTIV PLC | SHS | G6095L109 | 13,825 | 150,794 | SH | DFND | 0 | 150,794 | 0 | ||
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 4,114 | 240,000 | SH | Call | DFND | 0 | 240,000 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 43,483 | 2,536,932 | SH | DFND | 0 | 2,536,932 | 0 | ||
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 21,257 | 387,900 | SH | DFND | 0 | 387,900 | 0 | ||
| ATHIRA PHARMA INC | COM | 04746L104 | 7,245 | 392,489 | SH | DFND | 0 | 392,489 | 0 | ||
| AVANTOR INC | COM | 05352A100 | 28,564 | 1,270,070 | SH | DFND | 0 | 1,270,070 | 0 | ||
| AVIDITY BIOSCIENCES, INC. | COM | 05370A108 | 6,347 | 254,672 | SH | DFND | 0 | 254,672 | 0 | ||
| AVIDITY BIOSCIENCES, INC. | COM | 05370A108 | 4,648 | 186,483 | SH | DFND | 1 | 0 | 186,483 | 0 | |
| BIOGEN INC | COM | 09062X103 | 25,451 | 89,716 | SH | DFND | 0 | 89,716 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 21,774 | 286,200 | SH | Call | DFND | 0 | 286,200 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 53,260 | 700,052 | SH | DFND | 0 | 700,052 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | NOTE 0.599% 8/0 | 09061GAH4 | 42,361 | 40,300,000 | PRN | DFND | 0 | 40,300,000 | 0 | ||
| CONSTELLATION PHARMCETICLS I | COM | 210373106 | 26,236 | 1,294,977 | SH | DFND | 0 | 1,294,977 | 0 | ||
| DANAHER CORPORATION | COM | 235851102 | 35,242 | 163,663 | SH | DFND | 0 | 163,663 | 0 | ||
| DEERE & CO | COM | 244199105 | 16,918 | 76,336 | SH | DFND | 0 | 76,336 | 0 | ||
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 12,688 | 2,936,990 | SH | DFND | 0 | 2,936,990 | 0 | ||
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 38,940 | 487,842 | SH | DFND | 0 | 487,842 | 0 | ||
| FLUIDIGM CORP DEL | COM | 34385P108 | 7,849 | 1,056,343 | SH | DFND | 0 | 1,056,343 | 0 | ||
| GILEAD SCIENCES INC | COM | 375558103 | 22,117 | 350,000 | SH | Call | DFND | 0 | 350,000 | 0 | |
| GILEAD SCIENCES INC | COM | 375558103 | 68,124 | 1,078,089 | SH | DFND | 0 | 1,078,089 | 0 | ||
| HCA HEALTHCARE INC | COM | 40412C101 | 45,501 | 364,940 | SH | DFND | 0 | 364,940 | 0 | ||
| HENRY SCHEIN INC | COM | 806407102 | 23,648 | 402,310 | SH | DFND | 0 | 402,310 | 0 | ||
| HERON THERAPEUTICS INC | COM | 427746102 | 27,743 | 1,872,012 | SH | DFND | 0 | 1,872,012 | 0 | ||
| HOLOGIC INC | COM | 436440101 | 18,093 | 272,193 | SH | DFND | 0 | 272,193 | 0 | ||
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 105,600 | 1,359,420 | SH | DFND | 0 | 1,359,420 | 0 | ||
| HUMANA INC | COM | 444859102 | 32,176 | 77,740 | SH | DFND | 0 | 77,740 | 0 | ||
| ICON PLC | SHS | G4705A100 | 23,184 | 121,323 | SH | DFND | 0 | 121,323 | 0 | ||
| ICU MED INC | COM | 44930G107 | 55,376 | 302,999 | SH | DFND | 0 | 302,999 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 114,244 | 1,343,570 | SH | DFND | 0 | 1,343,570 | 0 | ||
| INVESCO QQQ TR | UNIT SER 1 | 46090E103 | 105,996 | 381,500 | SH | Put | DFND | 0 | 381,500 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 12,575 | 381,990 | SH | DFND | 0 | 381,990 | 0 | ||
| IQVIA HLDGS INC | COM | 46266C105 | 53,277 | 337,987 | SH | DFND | 0 | 337,987 | 0 | ||
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 39,766 | 167,008 | SH | DFND | 0 | 167,008 | 0 | ||
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 10,028 | 406,467 | SH | DFND | 0 | 406,467 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 10,667 | 137,960 | SH | DFND | 0 | 137,960 | 0 | ||
| LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 26,983 | 143,323 | SH | DFND | 0 | 143,323 | 0 | ||
| MERCK & CO. INC | COM | 58933Y105 | 28,203 | 340,000 | SH | Call | DFND | 0 | 340,000 | 0 | |
| MICROSOFT CORP | COM | 594918104 | 20,019 | 95,177 | SH | DFND | 0 | 95,177 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 26,086 | 157,100 | SH | Call | DFND | 0 | 157,100 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 41,358 | 249,068 | SH | DFND | 0 | 249,068 | 0 | ||
| MODERNA INC | COM | 60770K107 | 8,489 | 120,000 | SH | Put | DFND | 0 | 120,000 | 0 | |
| MOLINA HEALTHCARE INC | COM | 60855R100 | 29,748 | 162,524 | SH | DFND | 0 | 162,524 | 0 | ||
| MYOVANT SCIENCES LTD | COM | G637AM102 | 8,827 | 628,272 | SH | DFND | 0 | 628,272 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 44,330 | 318,232 | SH | DFND | 0 | 318,232 | 0 | ||
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 3,151 | 2,000,000 | PRN | DFND | 0 | 2,000,000 | 0 | ||
| NEXTERA ENERGY INC | COM | 65339F101 | 13,087 | 47,151 | SH | DFND | 0 | 47,151 | 0 | ||
| NVIDIA CORPORATION | COM | 67066G104 | 14,024 | 25,911 | SH | DFND | 0 | 25,911 | 0 | ||
| NXP SEMICONDUCTORS N V | COM | N6596X109 | 18,083 | 144,881 | SH | DFND | 0 | 144,881 | 0 | ||
| OUTSET MED INC | COM | 690145107 | 120,235 | 2,640,477 | SH | DFND | 0 | 2,640,477 | 0 | ||
| OUTSET MED INC | COM | 690145107 | 10,356 | 232,513 | SH | DFND | 1 | 0 | 232,513 | 0 | |
| PENUMBRA INC | COM | 70975L107 | 46,534 | 239,397 | SH | DFND | 0 | 239,397 | 0 | ||
| PERKINELMER INC | COM | 714046109 | 18,450 | 147,000 | SH | DFND | 0 | 147,000 | 0 | ||
| PFIZER INC | COM | 717081103 | 33,984 | 926,000 | SH | Call | DFND | 0 | 926,000 | 0 | |
| PFIZER INC | COM | 717081103 | 17,556 | 478,361 | SH | DFND | 0 | 478,361 | 0 | ||
| PPD INC | COM | 69355F102 | 29,143 | 787,863 | SH | DFND | 0 | 787,863 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 12,539 | 360,313 | SH | DFND | 0 | 360,313 | 0 | ||
| SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 8,351 | 193,585 | SH | DFND | 0 | 193,585 | 0 | ||
| SHOPIFY INC | CL A | 82509L107 | 9,671 | 9,454 | SH | DFND | 0 | 9,454 | 0 | ||
| SPDR SER TR | S&P BIOTECH | 78464A870 | 22,286 | 200,000 | SH | Put | DFND | 0 | 200,000 | 0 | |
| SQUARE INC | CL A | 852234103 | 29,504 | 181,509 | SH | DFND | 0 | 181,509 | 0 | ||
| TCR2 THERAPEUTICS INC | COM | 87808K106 | 15,764 | 775,794 | SH | DFND | 0 | 775,794 | 0 | ||
| TENET HEALTHCARE CORP | COM NEW | 88033G407 | 20,618 | 841,194 | SH | DFND | 0 | 841,194 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 16,005 | 1,126,325 | SH | DFND | 0 | 1,126,325 | 0 | ||
| VISA INC | COM CL A | 92826C839 | 8,692 | 43,468 | SH | DFND | 0 | 43,468 | 0 | ||
| ZENDESK INC | COM | 98936J101 | 6,899 | 67,034 | SH | DFND | 0 | 67,034 | 0 | ||