The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 2,835 110,478 SH   SOLE 110,478 0 0
ACCURAY INC COM 004397105 2,578 1,074,300 SH   SOLE 1,074,300 0 0
ADICET BIO INC COM 007002108 803 67,577 SH   SOLE 67,577 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 3,348 284,440 SH   SOLE 284,440 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,206 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED NV COM N01045108 3,133 924,278 SH   SOLE 924,278 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 858 341,779 SH   SOLE 341,779 0 0
ALECTOR INC COM 014442107 1,475 140,000 SH   SOLE 140,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,303 148,260 SH   SOLE 148,260 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 907 30,054 SH   SOLE 30,054 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 5,322 1,095,139 SH   SOLE 1,095,139 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 9,852 229,652 SH   SOLE 229,652 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,236 72,100 SH   SOLE 72,100 0 0
ARDELYX INC COM 039697107 759 144,650 SH   SOLE 144,650 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 5,670 75,815 SH   SOLE 75,815 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4,512 29,237 SH   SOLE 29,237 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 164 86,082 SH   SOLE 86,082 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 585 35,573 SH   SOLE 35,573 0 0
ATRICURE INC COM 04963C209 5,316 133,229 SH   SOLE 133,229 0 0
AXOVANT SCIENCES LTD COM G0750W203 790 171,083 SH   SOLE 171,083 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,573 749,051 SH   SOLE 749,051 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 5,500 84,600 SH   SOLE 84,600 0 0
BIOTELEMETRY INC COM 090672106 2,758 60,500 SH   SOLE 60,500 0 0
BLUEBIRD BIO INC COM 09609G100 1,633 30,273 SH   SOLE 30,273 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 21,607 233,089 SH   SOLE 233,089 0 0
CARA THERAPEUTICS INC COM 140755109 3,148 247,377 SH   SOLE 247,377 0 0
CARDIFF ONCOLOGY INC COM 14147L108 71 5,000 SH   SOLE 5,000 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 5,950 151,200 SH   SOLE 151,200 0 0
CHIASMA INC COM 16706W102 659 153,208 SH   SOLE 153,208 0 0
COMPUGEN LTD ORD M25722105 1,872 115,202 SH   SOLE 115,202 0 0
CONSTELLATION PHARMACEUTICAL COM 210373106 3,666 180,942 SH   SOLE 180,942 0 0
DEXCOM INC COM 252131107 8,714 21,138 SH   SOLE 21,138 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 664 156,529 SH   SOLE 156,529 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,172 454,236 SH   SOLE 454,236 0 0
FATE THERAPEUTICS INC COM 31189P102 17,525 438,460 SH   SOLE 438,460 0 0
GALAPAGOS NV SPON ADR 36315X101 6,297 44,375 SH   SOLE 44,375 0 0
GAMIDA CELL LTD SHS M47364100 581 140,000 SH   SOLE 140,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 1,446 85,119 SH   SOLE 85,119 0 0
HOOKIPA PHARMA INC COM 43906K100 209 22,061 SH   SOLE 22,061 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 4,166 331,661 SH   SOLE 331,661 0 0
IMMUNOMEDICS INC COM 452907108 22,185 260,905 SH   SOLE 260,905 0 0
INOGEN INC COM 45780L104 435 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 7,569 55,900 SH   SOLE 55,900 0 0
IVERIC BIO INC COM 46583P102 1,819 322,500 SH   SOLE 322,500 0 0
JOHNSON AND JOHNSON COM 478160104 1,399 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 2,209 563,564 SH   SOLE 563,564 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,619 208,054 SH   SOLE 208,054 0 0
KARUNA THERAPEUTICS INC COM 48576A100 714 9,231 SH   SOLE 9,231 0 0
KURA ONCOLOGY INC COM 50127T109 1,196 39,019 SH   SOLE 39,019 0 0
LARIMAR THERAPEUTICS INC COM 517125100 1,201 79,155 SH   SOLE 79,155 0 0
LINEAGE CELL THERAPEUTICS INC COM 53566P109 89 95,000 SH   SOLE 95,000 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 2,829 575,000 SH   SOLE 575,000 0 0
LUMINEX CORP COM 55027E102 4,045 154,091 SH   SOLE 154,091 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 784 6,600 SH   SOLE 6,600 0 0
MASIMO CORPORATION COM 574795100 708 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,078 666,000 SH   SOLE 666,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 522 199,425 SH   SOLE 199,425 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,844 152,763 SH   SOLE 152,763 0 0
NATUS MEDICAL INC COM 639050103 735 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,674 90,208 SH   SOLE 90,208 0 0
NEURONETICS INC COM 64131A105 2,409 495,772 SH   SOLE 495,772 0 0
NEXTCURE INC COM 65343E108 748 85,000 SH   SOLE 85,000 0 0
OTONOMY INC COM 68906L105 2,791 689,100 SH   SOLE 689,100 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 1,125 320,542 SH   SOLE 320,542 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 764 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 5,927 1,237,400 SH   SOLE 1,237,400 0 0
RADIUS HEALTH INC COM NEW 750469207 249 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,315 4,000,000 PRN   SOLE 4,000,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,676 158,306 SH   SOLE 158,306 0 0
SCPHARMACEUTICALS INC COM 810648105 677 90,900 SH   SOLE 90,900 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 2,101 514,891 SH   SOLE 514,891 0 0
SPERO THERAPEUTICS INC COM 84833T103 1,116 100,000 SH   SOLE 100,000 0 0
STEREOTAXIS INC COM NEW 85916J409 48,976 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 1,195 118,940 SH   SOLE 118,940 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,516 102,713 SH   SOLE 102,713 0 0
TRANSLATE BIO INC COM 89374L104 2,599 190,930 SH   SOLE 190,930 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 1,008 161,507 SH   SOLE 161,507 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,624 450,900 SH   SOLE 450,900 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,836 346,535 SH   SOLE 346,535 0 0
ZYMEWORKS INC COM 98985W102 463 9,950 SH   SOLE 9,950 0 0