The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 85,856 688,611 SH   DFND   0 0 688,611
1LIFE HEALTHCARE INC COM 68269G107 117,873 4,156,309 SH   DFND   0 0 4,156,309
2U INC COM 90214J101 1,932 57,051 SH   DFND   0 0 57,051
89BIO INC COM 282559103 827 32,248 SH   DFND   0 0 32,248
ABIOMED INC COM 003654100 35,512 128,174 SH   DFND   0 0 128,174
ACCEL ENTERTAINMENT INC COM CL A1 00436Q106 26 2,400 SH   DFND   0 0 2,400
ACCOLADE INC COM 00437E102 50,965 1,311,157 SH   DFND   0 0 1,311,157
ACTIVISION BLIZZARD INC COM 00507V109 1,684 20,806 SH   DFND   0 0 20,806
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 116,580 2,397,279 SH   DFND   0 0 2,397,279
ADOBE SYSTEMS INCORPORATED COM 00724F101 60,473 123,306 SH   DFND   0 0 123,306
ADYEN NV 144A COM N3501V104 60,879 33,015 SH   DFND   0 0 33,015
AFYA LTD CL A COM G01125106 6,798 249,551 SH   DFND   0 0 249,551
AGORA INC ADS 00851L103 11,045 256,982 SH   DFND   0 0 256,982
ALAMOS GOLD INC NEW COM CL A 011532108 4,604 522,620 SH   DFND   0 0 522,620
ALASKA COMMUNICATIONS SYS GR COM 01167P101 1,888 943,833 SH   DFND   0 0 943,833
ALECTOR INC COM 014442107 22,775 2,161,820 SH   DFND   0 0 2,161,820
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 125,324 426,302 SH   DFND   0 0 426,302
ALLAKOS INC COM 01671P100 3,548 43,564 SH   DFND   0 0 43,564
ALLOGENE THERAPEUTICS INC COM 019770106 2,331 61,816 SH   DFND   0 0 61,816
ALLOVIR INC COM 019818103 380 13,829 SH   DFND   0 0 13,829
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 129,645 890,416 SH   DFND   0 0 890,416
ALPHABET INC CAP STK CL A 02079K305 58,807 40,125 SH   DFND   0 0 40,125
ALPHABET INC CAP STK CL C 02079K107 67,516 45,942 SH   DFND   0 0 45,942
ALTERYX INC COM CL A 02156B103 3 30 SH   DFND   0 0 30
ALTUS MIDSTREAM CO COM NEW CL A 02215L209 644 57,929 SH   DFND   0 0 57,929
AMAZON COM INC COM 023135106 497,665 158,053 SH   DFND   0 0 158,053
AMERICAN TOWER CORP NEW COM 03027X100 18,313 75,758 SH   DFND   0 0 75,758
AMERICAN WELL CORP CL A 03044L105 2,951 99,561 SH   DFND   0 0 99,561
AMICUS THERAPEUTICS INC COM 03152W109 29,437 2,084,742 SH   DFND   0 0 2,084,742
AMYRIS INC COM NEW 03236M200 150 51,369 SH   DFND   0 0 51,369
ANAPLAN INC COM 03272L108 3 41 SH   DFND   0 0 41
ANTERIX INC COM 03676C100 1,508 46,117 SH   DFND   0 0 46,117
APACHE CORP COM 037411105 1,542 162,809 SH   DFND   0 0 162,809
APPFOLIO INC COM CL A 03783C100 63,081 444,827 SH   DFND   0 0 444,827
APPIAN CORP CL A 03782L101 1,600 24,709 SH   DFND   0 0 24,709
APPLE INC COM 037833100 19,997 172,667 SH   DFND   0 0 172,667
APPLIED OPTOELECTRONICS INC COM 03823U102 79 7,050 SH   DFND   0 0 7,050
APTOSE BIOSCIENCES INC COM NEW 03835T200 1 125 SH   DFND   0 0 125
ARCUS BIOSCIENCES INC COM 03969F109 14,923 870,634 SH   DFND   0 0 870,634
ARENA PHARMACEUTICALS INC COM NEW 040047607 48,101 643,147 SH   DFND   0 0 643,147
ARGENX SE SPONSORED ADR 04016X101 35,907 136,779 SH   DFND   0 0 136,779
ARISTA NETWORKS INC COM 040413106 6,264 30,269 SH   DFND   0 0 30,269
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2 COM 04045U102 10,025 768,271 SH   DFND   0 0 768,271
ARVINAS INC COM 04335A105 31,289 1,325,260 SH   DFND   0 0 1,325,260
ASHTEAD GROUP ORD GBP010 ISIN GB0000536739 SEDOL 0053673 COM G05320109 3 85 SH   DFND   0 0 85
ATLASSIAN CORP PLC CL A G06242104 37,054 203,830 SH   DFND   0 0 203,830
ATRICURE INC COM 04963C209 13,474 337,689 SH   DFND   0 0 337,689
AUTO TRADER GROUP PLC ORD GBP001 ISIN GB00BVYVFW23 SEDOL BVYV COM G06708104 1,515 208,213 SH   DFND   0 0 208,213
AUTODESK INC COM 052769106 125,734 544,281 SH   DFND   0 0 544,281
AVIDITY BIOSCIENCES INC COM 05370A108 277 9,828 SH   DFND   0 0 9,828
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN US05462W1099 SEDOL COM 05462W109 1,921 65,353 SH   DFND   0 0 65,353
AXOGEN INC COM 05463X106 287 24,713 SH   DFND   0 0 24,713
AZEK CO INC CL A 05478C105 20,081 576,869 SH   DFND   0 0 576,869
AZUL S A SPONSR ADR PFD 05501U106 16,458 1,250,594 SH   DFND   0 0 1,250,594
BAMBUSER AB NPV ISIN SE0009663834 SEDOL BD8Z3Y2 COM W1R91S102 8,933 8,092,012 SH   DFND   0 0 8,092,012
BARCLAYS BANK PLC IPTH SR B S&P 06746P621 7,333 294,512 SH   DFND   0 0 294,512
BASICFIT NV 144A REG S ISIN NL0011872650 SEDOL BD9Y9B7 COM N10058100 11 457 SH   DFND   0 0 457
BEAM THERAPEUTICS INC COM 07373V105 2,616 106,263 SH   DFND   0 0 106,263
BERKLEY W R CORP COM 084423102 4,894 80,034 SH   DFND   0 0 80,034
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 723 3,394 SH   DFND   0 0 3,394
BEYOND MEAT INC COM 08862E109 114,726 690,870 SH   DFND   0 0 690,870
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,034 592,200 SH   DFND   0 0 592,200
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 6,616 101,771 SH   DFND   0 0 101,771
BLACKROCK GOLD CORP COM NPV ISIN CA09258M1014 SEDOL BDCQFK1 COM 09258M101 2,483 3,727,108 SH   DFND   0 0 3,727,108
BLUEBIRD BIO INC COM 09609G100 23,826 441,638 SH   DFND   0 0 441,638
BOSTON SCIENTIFIC CORP COM 101137107 812 21,260 SH   DFND   0 0 21,260
BRP GROUP INC COM CL A 05589G102 10,734 430,912 SH   DFND   0 0 430,912
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 33 1,300 SH   DFND   0 0 1,300
CALIX INC COM 13100M509 56,121 3,156,403 SH   DFND   0 0 3,156,403
CALVERT US LRG CAP CORE RESPNSBL INDX C COM 131582769 20 729 SH   DFND   0 0 729
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961 COM D14895102 1,518 11,983 SH   DFND   0 0 11,983
CARVANA CO CL A 146869102 324,229 1,453,550 SH   DFND   0 0 1,453,550
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76 COM Q2159P101 280 186,684 SH   DFND   0 0 186,684
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOL COM E2R41M104 12,241 200,749 SH   DFND   0 0 200,749
CELSIUS HLDGS INC COM NEW 15118V207 11,918 524,802 SH   DFND   0 0 524,802
CHARLES RIV LABS INTL INC COM 159864107 5,678 25,073 SH   DFND   0 0 25,073
CHART INDS INC COM PAR $0.01 16115Q308 43 607 SH   DFND   0 0 607
CHEGG INC COM 163092109 117,123 1,639,464 SH   DFND   0 0 1,639,464
CHEWY INC CL A 16679L109 20,379 371,669 SH   DFND   0 0 371,669
CHIPOTLE MEXICAN GRILL INC COM 169656105 1 1 SH   DFND   0 0 1
CHUBB LIMITED COM H1467J104 12,597 108,480 SH   DFND   0 0 108,480
CITIGROUP INC COM NEW 172967424 2 35 SH   DFND   0 0 35
CLEARFIELD INC COM 18482P103 691 34,260 SH   DFND   0 0 34,260
CLOUDFLARE INC CL A COM 18915M107 215,226 5,241,741 SH   DFND   0 0 5,241,741
CODEXIS INC COM 192005106 29,622 2,523,168 SH   DFND   0 0 2,523,168
CONTROLADORA VUELA COMP DE A SPON ADR RP 10 21240E105 21,395 2,967,413 SH   DFND   0 0 2,967,413
CORECIVIC INC COM 21871N101 65 8,079 SH   DFND   0 0 8,079
COUPA SOFTWARE INC COM 22266L106 103,787 378,453 SH   DFND   0 0 378,453
COVETRUS INC COM 22304C100 0 8 SH   DFND   0 0 8
CREE INC COM 225447101 966 15,158 SH   DFND   0 0 15,158
CRIMSON WINE GROUP COM USD001 COM 22662X100 89 17,996 SH   DFND   0 0 17,996
CROWDSTRIKE HLDGS INC CL A 22788C105 71,973 524,125 SH   DFND   0 0 524,125
D R HORTON INC COM 23331A109 4,502 59,530 SH   DFND   0 0 59,530
DATADOG INC CL A COM 23804L103 23,890 233,844 SH   DFND   0 0 233,844
DELTA AIR LINES INC DEL COM NEW 247361702 277 9,050 SH   DFND   0 0 9,050
DENALI THERAPEUTICS INC COM 24823R105 118,817 3,316,130 SH   DFND   0 0 3,316,130
DEXCOM INC COM 252131107 186,227 451,756 SH   DFND   0 0 451,756
DISH NETWORK CORPORATION CL A 25470M109 52,809 1,819,135 SH   DFND   0 0 1,819,135
DISNEY WALT CO COM DISNEY 254687106 4,363 35,162 SH   DFND   0 0 35,162
DIVERSIFIED GAS OIL PLC ORD GBP001 ISIN GB00BYX7JT74 SEDOL B COM G2891G105 9,915 7,304,538 SH   DFND   0 0 7,304,538
DOCUSIGN INC COM 256163106 315,969 1,467,985 SH   DFND   0 0 1,467,985
DOWNEY FINL CORP COM 261018105 0 200 SH   DFND   0 0 200
DRAFTKINGS INC COM CL A 26142R104 1,909 32,441 SH   DFND   0 0 32,441
EHEALTH INC COM 28238P109 12,075 152,845 SH   DFND   0 0 152,845
EIDOS THERAPEUTICS INC COM 28249H104 16,945 335,349 SH   DFND   0 0 335,349
ELASTIC N V ORD SHS N14506104 4,617 42,797 SH   DFND   0 0 42,797
EMERGENT BIOSOLUTIONS INC COM 29089Q105 4,192 40,568 SH   DFND   0 0 40,568
ENPHASE ENERGY INC COM 29355A107 190,474 2,306,256 SH   DFND   0 0 2,306,256
ENTERCOM COMMUNICATIONS CORP CL A 293639100 42 26,326 SH   DFND   0 0 26,326
EPAM SYS INC COM 29414B104 117,273 362,760 SH   DFND   0 0 362,760
EQUATOR EXPLORATION COM STK NPV COM G3084F128 0 215,000 SH   DFND   0 0 215,000
EROS STX GLOBAL CORPORATION SHS NEW G3788M114 44 19,905 SH   DFND   0 0 19,905
ESPERION THERAPEUTICS INC NE COM 29664W105 42 1,128 SH   DFND   0 0 1,128
ETSY INC COM 29786A106 41,562 341,706 SH   DFND   0 0 341,706
EVEREST RE GROUP LTD COM G3223R108 3,498 17,709 SH   DFND   0 0 17,709
EXACT SCIENCES CORP COM 30063P105 138,942 1,362,848 SH   DFND   0 0 1,362,848
FACEBOOK INC CL A 30303M102 80,815 308,572 SH   DFND   0 0 308,572
FASTLY INC CL A 31188V100 39,527 421,933 SH   DFND   0 0 421,933
FATHOM HOLDINGS INC COM 31189V109 7,482 475,350 SH   DFND   0 0 475,350
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4 COM G3421J106 10,945 108,375 SH   DFND   0 0 108,375
FLEX LNG LTD BM USD010 ISIN BMG359472021 SEDOL BJJMGB2 COM ZZCKKNHC2 381 67,402 SH   DFND   0 0 67,402
FLOOR & DECOR HLDGS INC CL A 339750101 130,996 1,751,286 SH   DFND   0 0 1,751,286
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634 COM G36545104 94 270,000 SH   DFND   0 0 270,000
FRANCO NEV CORP COM 351858105 10,195 73,038 SH   DFND   0 0 73,038
FRANKLIN INCOME CLASS C COM 353496805 15 7,137 SH   DFND   0 0 7,137
FRESHPET INC COM 358039105 230,800 2,067,171 SH   DFND   0 0 2,067,171
FRIENDLY ENERGY EXPLORATION COM NPV COM 35846A200 0 690 SH   DFND   0 0 690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5 COM B44170106 39,287 276,423 SH   DFND   0 0 276,423
GEOPARK LTD USD SHS G38327105 2,763 375,453 SH   DFND   0 0 375,453
GLAUKOS CORP COM 377322102 43,675 881,972 SH   DFND   0 0 881,972
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 388 7,028 SH   DFND   0 0 7,028
GLOBANT S A COM L44385109 107,287 598,636 SH   DFND   0 0 598,636
GOLDEN MINERALS CO COM 381119106 20 47,017 SH   DFND   0 0 47,017
GOLDMAN SACHS GROUP INC COM 38141G104 70,198 349,297 SH   DFND   0 0 349,297
GOODRX HLDGS INC COM CL A 38246G108 278 5,000 SH   DFND   0 0 5,000
GROCERY OUTLET HLDG CORP COM 39874R101 3,933 100,014 SH   DFND   0 0 100,014
GTT COMMUNICATIONS INC COM 362393100 4,743 919,090 SH   DFND   0 0 919,090
GUARDANT HEALTH INC COM 40131M109 976 8,727 SH   DFND   0 0 8,727
H & E EQUIPMENT SERVICES INC COM 404030108 2,609 132,709 SH   DFND   0 0 132,709
HDFC BANK LTD SPONSORED ADS 40415F101 7,145 143,009 SH   DFND   0 0 143,009
HEALTHEQUITY INC COM 42226A107 1,153 22,448 SH   DFND   0 0 22,448
HEARUSA INC NEW COM 422360305 0 375 SH   DFND   0 0 375
HEICO CORP NEW CL A 422806208 4,554 51,364 SH   DFND   0 0 51,364
HEICO CORP NEW COM 422806109 2,116 20,219 SH   DFND   0 0 20,219
HELLOFRESH SE ISIN DE000A161408 SEDOL BYWH8S0 COM D3R2MA100 36,100 647,014 SH   DFND   0 0 647,014
HUBSPOT INC COM 443573100 178,480 610,753 SH   DFND   0 0 610,753
ICICI BANK LIMITED ADR 45104G104 2,835 288,450 SH   DFND   0 0 288,450
IDEXX LABS INC COM 45168D104 3,805 9,678 SH   DFND   0 0 9,678
ILLUMINA INC COM 452327109 2,434 7,875 SH   DFND   0 0 7,875
IMPINJ INC COM 453204109 12,653 480,192 SH   DFND   0 0 480,192
INARI MED INC COM 45332Y109 9,918 143,699 SH   DFND   0 0 143,699
INFINERA CORP COM 45667G103 55,789 9,056,677 SH   DFND   0 0 9,056,677
INPHI CORP COM 45772F107 20,751 184,863 SH   DFND   0 0 184,863
INSPIRE MED SYS INC COM 457730109 128,916 998,964 SH   DFND   0 0 998,964
INSULET CORP COM 45784P101 5,134 21,701 SH   DFND   0 0 21,701
INTERBREW PLC GDREACH REPR 1 A SH REG S COM 45845T308 0 200 SH   DFND   0 0 200
INTL GNRL INSURANCE HLDNGS L SHS G4809J106 13,642 1,907,912 SH   DFND   0 0 1,907,912
INTUITIVE SURGICAL INC COM NEW 46120E602 122,271 172,324 SH   DFND   0 0 172,324
INVITAE CORP COM 46185L103 307,412 7,091,386 SH   DFND   0 0 7,091,386
IRHYTHM TECHNOLOGIES INC COM 450056106 94,472 396,756 SH   DFND   0 0 396,756
IWG PLC ORD GBP001 ISIN JE00BYVQYS01 SEDOL BYVQYS0 COM G4969N103 54,062 16,083,661 SH   DFND   0 0 16,083,661
JAMF HLDG CORP COM 47074L105 11,133 296,022 SH   DFND   0 0 296,022
JPMORGAN CHASE & CO COM 46625H100 1,565 16,253 SH   DFND   0 0 16,253
JUST EAT TAKEAWAYCOM NV EUR004 144A REG S ISIN NL0012015705 COM ZZDLN2RN7 224 1,990 SH   DFND   0 0 1,990
KAMBI GROUP PLC EUR0003 ISIN MT0000780107 SEDOL BMNQDC1 COM X4170A107 37 1,118 SH   DFND   0 0 1,118
KB HOME COM 48666K109 313 8,147 SH   DFND   0 0 8,147
KIRKLAND LAKE GOLD LTD CALL 49741E900 16,304 334,573 SH   DFND   0 0 334,573
KORNIT DIGITAL LTD SHS M6372Q113 91,980 1,417,919 SH   DFND   0 0 1,417,919
KRYSTAL BIOTECH INC COM 501147102 308 7,146 SH   DFND   0 0 7,146
KURA SUSHI USA INC CL A COM 501270102 39 2,973 SH   DFND   0 0 2,973
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 518 16,768 SH   DFND   0 0 16,768
LEMONADE INC COM 52567D107 5,056 101,683 SH   DFND   0 0 101,683
LGI HOMES INC COM 50187T106 125,775 1,082,678 SH   DFND   0 0 1,082,678
LI NING CO LTD HKD01 ISIN KYG5496K1242 SEDOL B01JCK9 COM G5496K124 21 4,621 SH   DFND   0 0 4,621
LIBERTY MEDIA CORP DEL COM A BRAVES GRP 531229706 2,660 127,390 SH   DFND   0 0 127,390
LIBERTY MEDIA CORP DEL COM C BRAVES GRP 531229888 4,721 224,707 SH   DFND   0 0 224,707
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 2,296 63,296 SH   DFND   0 0 63,296
LIVE NATION ENTERTAINMENT IN COM 538034109 15 278 SH   DFND   0 0 278
LIVEPERSON INC COM 538146101 52 1,000 SH   DFND   0 0 1,000
LIVONGO HEALTH INC COM 539183103 203,695 1,454,443 SH   DFND   0 0 1,454,443
LOVESAC COMPANY COM 54738L109 788 28,423 SH   DFND   0 0 28,423
LULULEMON ATHLETICA INC COM 550021109 37,406 113,567 SH   DFND   0 0 113,567
LUMENTUM HLDGS INC COM 55024U109 759 10,096 SH   DFND   0 0 10,096
LYFT INC CL A COM 55087P104 1,206 43,770 SH   DFND   0 0 43,770
MAG SILVER CORP COM 55903Q104 25,783 1,585,661 SH   DFND   0 0 1,585,661
MAGENTA THERAPEUTICS INC COM 55910K108 29,004 4,265,282 SH   DFND   0 0 4,265,282
MAGNOLIA OIL & GAS CORP CL A 559663109 2,281 441,202 SH   DFND   0 0 441,202
MAINSTAY EPOCH GL EQUITY YIELD CL C COM 56063J872 9 540 SH   DFND   0 0 540
MARTIN MARIETTA MATLS INC COM 573284106 25,734 109,338 SH   DFND   0 0 109,338
MASTERCARD INCORPORATED CL A 57636Q104 26,936 79,652 SH   DFND   0 0 79,652
MATCH GROUP INC NEW COM 57667L107 99,351 897,888 SH   DFND   0 0 897,888
MAXAR TECHNOLOGIES INC COM 57778K105 32,101 1,287,116 SH   DFND   0 0 1,287,116
MAYVILLE ENGINEERING CO INC COM 578605107 513 55,860 SH   DFND   0 0 55,860
MERCADOLIBRE INC COM 58733R102 157,793 145,770 SH   DFND   0 0 145,770
MGP INGREDIENTS INC NEW COM 55303J106 835 21,012 SH   DFND   0 0 21,012
MICROSOFT CORP COM 594918104 60,964 289,848 SH   DFND   0 0 289,848
MOLECULAR TEMPLATES INC COM 608550109 5,615 514,159 SH   DFND   0 0 514,159
MONGODB INC CL A 60937P106 173,393 748,965 SH   DFND   0 0 748,965
MONOLITHIC PWR SYS INC COM 609839105 12,449 44,521 SH   DFND   0 0 44,521
MYOKARDIA INC COM 62857M105 1,690 12,395 SH   DFND   0 0 12,395
MYOVANT SCIENCES LTD COM G637AM102 2,587 184,128 SH   DFND   0 0 184,128
NATERA INC COM 632307104 96,569 1,336,778 SH   DFND   0 0 1,336,778
NATIONAL VISION HLDGS INC COM 63845R107 23 603 SH   DFND   0 0 603
NETCOMPANY GROUP AS DKK1 144A ISIN DK0060952919 SEDOL BFYDWS1 COM K7020C102 77,606 935,654 SH   DFND   0 0 935,654
NETFLIX INC COM 64110L106 543,088 1,086,110 SH   DFND   0 0 1,086,110
NEW PACIFIC METALS CORP COM NPV ISIN CA6478241012 SEDOL BF4CP8 COM 647824101 10,226 2,120,979 SH   DFND   0 0 2,120,979
NEW YORK TIMES CO CL A 650111107 120,494 2,815,928 SH   DFND   0 0 2,815,928
NIKE INC CL B 654106103 17,361 138,289 SH   DFND   0 0 138,289
NINTENDO 8 ADR REP ORD COM 654445303 333 4,713 SH   DFND   0 0 4,713
NIU TECHNOLOGIES ADS 65481N100 206 10,707 SH   DFND   0 0 10,707
NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST 65506L105 7 910 SH   DFND   0 0 910
NORDSTROM INC COM 655664100 1,184 99,298 SH   DFND   0 0 99,298
NORTHERN DATA AG ORD SHS ISIN DE000A0SMU87 SEDOL BWT5WX6 COM D5S1LG112 210 3,371 SH   DFND   0 0 3,371
NV5 GLOBAL INC COM 62945V109 34 644 SH   DFND   0 0 644
NVIDIA CORPORATION COM 67066G104 116,444 215,152 SH   DFND   0 0 215,152
NYXOAH SA NPV ISIN BE0974358906 SEDOL BN782G7 COM B6S7WD106 2,443 106,274 SH   DFND   0 0 106,274
OAK STR HEALTH INC COM 67181A107 106,509 1,993,055 SH   DFND   0 0 1,993,055
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74 COM G6718L106 374,269 10,550,378 SH   DFND   0 0 10,550,378
OKTA INC CL A 679295105 322,736 1,509,169 SH   DFND   0 0 1,509,169
ONEWATER MARINE INC CL A COM 68280L101 18,985 926,552 SH   DFND   0 0 926,552
OPTION CARE HEALTH INC COM NEW 68404L201 31,373 2,346,538 SH   DFND   0 0 2,346,538
OUTSET MED INC COM 690145107 4,901 98,017 SH   DFND   0 0 98,017
PAGERDUTY INC COM 69553P100 3,891 143,515 SH   DFND   0 0 143,515
PALANTIR TECHNOLOGIES INC CL A 69608A108 180 18,987 SH   DFND   0 0 18,987
PALOMAR HLDGS INC COM 69753M105 15,021 144,098 SH   DFND   0 0 144,098
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN CA6993202069 S COM 699320206 149 95,783 SH   DFND   0 0 95,783
PAYPAL HLDGS INC COM 70450Y103 39,498 200,469 SH   DFND   0 0 200,469
PDF SOLUTIONS INC COM 693282105 520 27,772 SH   DFND   0 0 27,772
PELOTON INTERACTIVE INC CL A COM 70614W100 358,907 3,616,555 SH   DFND   0 0 3,616,555
PENN NATL GAMING INC COM 707569109 46,866 644,643 SH   DFND   0 0 644,643
PENN TREATY AMERN CORP COM NEW COM 707874400 0 125 SH   DFND   0 0 125
PENSKE AUTOMOTIVE GRP INC COM 70959W103 2,853 59,871 SH   DFND   0 0 59,871
PENUMBRA INC COM 70975L107 415 2,133 SH   DFND   0 0 2,133
PINDUODUO INC SPONSORED ADS 722304102 18,585 250,637 SH   DFND   0 0 250,637
PINTEREST INC CL A 72352L106 918 22,121 SH   DFND   0 0 22,121
POOL CORP COM 73278L105 110,247 329,547 SH   DFND   0 0 329,547
PREVAIL THERAPEUTICS INC COM 74140Y101 0 5 SH   DFND   0 0 5
PROFOUND MED CORP COM NEW 74319B502 2,363 133,931 SH   DFND   0 0 133,931
PROOFPOINT INC COM 743424103 4,796 45,441 SH   DFND   0 0 45,441
PROVENTION BIO INC COM 74374N102 27,602 2,151,402 SH   DFND   0 0 2,151,402
PURPLE INNOVATION INC COM 74640Y106 26,128 1,051,013 SH   DFND   0 0 1,051,013
Q2 HLDGS INC COM 74736L109 57,963 635,144 SH   DFND   0 0 635,144
QUANTERIX CORP COM 74766Q101 99,519 2,949,599 SH   DFND   0 0 2,949,599
QUIDEL CORP COM 74838J101 8,305 37,855 SH   DFND   0 0 37,855
QUOTIENT LTD SHS G73268107 570 110,808 SH   DFND   0 0 110,808
REDFIN CORP COM 75737F108 33,652 673,977 SH   DFND   0 0 673,977
REECE LIMITED NPV ISIN AU000000REH4 SEDOL 6728801 COM Q80528138 2,949 317,675 SH   DFND   0 0 317,675
REGENERON PHARMACEUTICALS COM 75886F107 3,734 6,671 SH   DFND   0 0 6,671
RELAY THERAPEUTICS INC COM 75943R102 86,266 2,025,501 SH   DFND   0 0 2,025,501
RENAISSANCERE HLDGS LTD COM G7496G103 3,348 19,724 SH   DFND   0 0 19,724
RENALYTIX AI PLC ADS 75973T101 30,469 2,499,532 SH   DFND   0 0 2,499,532
RENALYTIX AI PLC ORD GBP00025 ISIN GB00BYWL4Y04 SEDOL BYWL4Y0 COM G7489R108 1,257 228,792 SH   DFND   0 0 228,792
REPARE THERAPEUTICS INC COM 760273102 100 3,239 SH   DFND   0 0 3,239
REPLIGEN CORP COM 759916109 71,255 482,953 SH   DFND   0 0 482,953
REYNA SILVER CORP COM NPV ISIN CA76170Q1063 SEDOL BMG11D0 COM 76170Q106 1,597 2,344,727 SH   DFND   0 0 2,344,727
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2 COM G7565D106 6,909 852,608 SH   DFND   0 0 852,608
RINGCENTRAL INC CL A 76680R206 264,245 962,254 SH   DFND   0 0 962,254
ROKU INC COM CL A 77543R102 419,073 2,219,664 SH   DFND   0 0 2,219,664
ROYALTY PHARMA PLC SHS CL A G7709Q104 2,525 60,015 SH   DFND   0 0 60,015
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6 COM V74587102 25,687 93,840,157 SH   DFND   0 0 93,840,157
SAFETY INS GROUP INC COM 78648T100 321 4,645 SH   DFND   0 0 4,645
SALESFORCE COM INC COM 79466L302 44,941 178,819 SH   DFND   0 0 178,819
SAREPTA THERAPEUTICS INC COM 803607100 121,366 864,248 SH   DFND   0 0 864,248
SCHRODINGER INC COM 80810D103 19,530 411,064 SH   DFND   0 0 411,064
SCIENTIFIC GAMES CORP COM 80874P109 381 10,904 SH   DFND   0 0 10,904
SCOTTS MIRACLE GRO CO CL A 810186106 55,267 361,432 SH   DFND   0 0 361,432
SELECTQUOTE INC COM 816307300 81 4,003 SH   DFND   0 0 4,003
SEMLER SCIENTIFIC INC COM USD0001 COM 81684M104 2,941 55,094 SH   DFND   0 0 55,094
SENESTECH INC COM NEW 81720R208 69 36,900 SH   DFND   0 0 36,900
SENSEONICS HLDGS INC COM 81727U105 5,638 14,558,073 SH   DFND   0 0 14,558,073
SERES THERAPEUTICS INC COM 81750R102 90,179 3,185,420 SH   DFND   0 0 3,185,420
SERVICENOW INC COM 81762P102 53,776 110,878 SH   DFND   0 0 110,878
SHAKE SHACK INC CL A 819047101 192,823 2,990,433 SH   DFND   0 0 2,990,433
SHERWIN WILLIAMS CO COM 824348106 1,099 1,577 SH   DFND   0 0 1,577
SHOCKWAVE MED INC COM 82489T104 142,711 1,882,729 SH   DFND   0 0 1,882,729
SHOPIFY INC CL A 82509L107 432,181 422,477 SH   DFND   0 0 422,477
SHOTSPOTTER INC COM 82536T107 61,189 1,971,292 SH   DFND   0 0 1,971,292
SI BONE INC COM 825704109 47,090 1,985,250 SH   DFND   0 0 1,985,250
SILK RD MED INC COM 82710M100 7,912 117,728 SH   DFND   0 0 117,728
SILVERCREST METALS INC COM 828363101 72,067 8,488,411 SH   DFND   0 0 8,488,411
SINTX TECHNOLOGIES INC COM NEW 829392307 0 71 SH   DFND   0 0 71
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 31,095 254,983 SH   DFND   0 0 254,983
SITIME CORP COM 82982T106 17,323 206,150 SH   DFND   0 0 206,150
SKEENA RESOURCES COM NPVPOST REV SPLT ISIN CA83056P8064 SEDOL COM 83056P806 8,130 3,977,774 SH   DFND   0 0 3,977,774
SLACK TECHNOLOGIES INC COM CL A 83088V102 352 13,122 SH   DFND   0 0 13,122
SMARTSHEET INC COM CL A 83200N103 550 11,126 SH   DFND   0 0 11,126
SNAP INC CL A 83304A106 62,809 2,405,551 SH   DFND   0 0 2,405,551
SNOWFLAKE INC CL A 833445109 35,301 140,643 SH   DFND   0 0 140,643
SOCIAL CAP HDOSPHIA HLDG CO SHS CL A G8250T109 14,575 767,494 SH   DFND   0 0 767,494
SONOS INC COM 83570H108 793 52,247 SH   DFND   0 0 52,247
SPDR GOLD TR GOLD SHS 78463V107 14,945 84,379 SH   DFND   0 0 84,379
SPLUNK INC COM 848637104 16,115 85,658 SH   DFND   0 0 85,658
SPORTSMANS WHSE HLDGS INC COM 84920Y106 4,272 298,537 SH   DFND   0 0 298,537
SPOTIFY TECHNOLOGY S A SHS L8681T102 165,296 681,435 SH   DFND   0 0 681,435
SPROUT SOCIAL INC COM CL A 85209W109 12,875 334,404 SH   DFND   0 0 334,404
SQUARE INC CL A 852234103 162,223 997,987 SH   DFND   0 0 997,987
SS&C TECHNOLOGIES HLDGS INC COM 78467J100 36,283 599,527 SH   DFND   0 0 599,527
STAAR SURGICAL CO COM PAR $0.01 852312305 12 212 SH   DFND   0 0 212
STAMPS COM INC COM NEW 852857200 466 1,932 SH   DFND   0 0 1,932
STAR BULK CARRIERS CORP. SHS PAR Y8162K204 69 10,000 SH   DFND   0 0 10,000
STARBUCKS CORP COM 855244109 1,174 13,660 SH   DFND   0 0 13,660
STOKE THERAPEUTICS INC COM 86150R107 49,905 1,490,153 SH   DFND   0 0 1,490,153
STONECO LTD COM CL A G85158106 86,735 1,639,916 SH   DFND   0 0 1,639,916
SUNRUN INC COM 86771W105 111,175 1,442,517 SH   DFND   0 0 1,442,517
SUNTIMES MEDIA GROUP INC CLASS A COM USD001 NO STOCKHOLDER EQU COM 86688Q100 0 650 SH   DFND   0 0 650
SVB FINANCIAL GROUP COM 78486Q101 5,852 24,321 SH   DFND   0 0 24,321
SVMK INC COM 78489X103 3,147 142,345 SH   DFND   0 0 142,345
TACTILE SYS TECHNOLOGY INC COM 87357P100 150 4,103 SH   DFND   0 0 4,103
TAL EDUCATION GROUP SPONSORED ADS 874080104 120,861 1,589,441 SH   DFND   0 0 1,589,441
TALON THERAPEUTICS CVR NEW COM 874CNT108 0 125 SH   DFND   0 0 125
TANDEM DIABETES CARE INC COM NEW 875372203 158,941 1,400,361 SH   DFND   0 0 1,400,361
TAYSHA GENE THERAPIES INC COM SHS 877619106 972 43,410 SH   DFND   0 0 43,410
TELADOC HEALTH INC COM 87918A105 186,863 852,323 SH   DFND   0 0 852,323
TENCENT HOLDINGS LIMITED HKD000002 ISIN KYG875721634 SEDOL BM COM G87572163 88,105 1,334,929 SH   DFND   0 0 1,334,929
TESLA INC COM 88160R101 987,727 2,302,340 SH   DFND   0 0 2,302,340
THE A2 MILK COMPANY LTD NPV ISIN NZATME0002S8 SEDOL BWSRTS7 COM ZZCXTSUT2 1,972 195,831 SH   DFND   0 0 195,831
THOR INDS INC COM 885160101 5,064 53,163 SH   DFND   0 0 53,163
T-MOBILE US INC COM 872590104 77,239 675,398 SH   DFND   0 0 675,398
TRANSDIGM GROUP INC COM 893641100 7,993 16,824 SH   DFND   0 0 16,824
TREAN INS GROUP INC COM 89457R101 2,562 168,004 SH   DFND   0 0 168,004
TRINE ACQUISITION CORP COM CL A 89628U108 136 12,627 SH   DFND   0 0 12,627
TRUPANION INC COM 898202106 47,199 598,210 SH   DFND   0 0 598,210
TWILIO INC CL A 90138F102 24,340 98,508 SH   DFND   0 0 98,508
TWIST BIOSCIENCE CORP COM 90184D100 973 12,808 SH   DFND   0 0 12,808
TWITTER INC COM 90184L102 3,616 81,251 SH   DFND   0 0 81,251
UBER TECHNOLOGIES INC COM 90353T100 46,401 1,271,953 SH   DFND   0 0 1,271,953
UNITY SOFTWARE INC COM 91332U101 81,479 933,532 SH   DFND   0 0 933,532
VANECK VECTORS ETF TR GOLD MINERS ETF 92189F106 30,142 769,719 SH   DFND   0 0 769,719
VEEVA SYS INC CL A COM 922475108 17,332 61,637 SH   DFND   0 0 61,637
VERACYTE INC COM 92337F107 99,994 3,077,700 SH   DFND   0 0 3,077,700
VERIZON COMMUNICATIONS INC COM 92343V104 13,575 228,195 SH   DFND   0 0 228,195
VICOR CORP COM 925815102 5,289 68,039 SH   DFND   0 0 68,039
VIR BIOTECHNOLOGY INC COM 92764N102 1,855 54,034 SH   DFND   0 0 54,034
VIRGIN GALACTIC HOLDINGS INC COM 92766K106 553 28,734 SH   DFND   0 0 28,734
VISA INC COM CL A 92826C839 410 2,049 SH   DFND   0 0 2,049
VITAL FARMS INC COM 92847W103 9,992 246,531 SH   DFND   0 0 246,531
VULCAN MATLS CO COM 929160109 4,045 29,845 SH   DFND   0 0 29,845
WATSCO INC COM 942622200 87,812 377,055 SH   DFND   0 0 377,055
WHEATON PRECIOUS METALS CORP COM 962879102 3,839 78,243 SH   DFND   0 0 78,243
WHITING PETE CORP NEW COM NEW 966387508 11,731 678,483 SH   DFND   0 0 678,483
WILLOW BIOSCIENCES INC COM NPV POST REV SPLIT ISIN CA97111B40 COM 97111B404 264 476,920 SH   DFND   0 0 476,920
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 7,427 445,250 SH   DFND   0 0 445,250
WORKDAY INC CL A 98138H101 19,630 91,247 SH   DFND   0 0 91,247
WUXI BIOLOGICS CAYMAN INC USD0000025 144A REG S ISIN KYG9700 COM G97008109 74,783 3,073,012 SH   DFND   0 0 3,073,012
WYNN RESORTS LTD COM 983134107 110 1,533 SH   DFND   0 0 1,533
XP INC CL A G98239109 27,427 657,882 SH   DFND   0 0 657,882
XYLEM INC COM 98419M100 30,479 362,331 SH   DFND   0 0 362,331
ZAI LAB LTD ADR 98887Q104 92,401 1,110,984 SH   DFND   0 0 1,110,984
ZILLOW GROUP INC CL A 98954M101 423 4,163 SH   DFND   0 0 4,163
ZILLOW GROUP INC CL C CAP STK 98954M200 87,377 860,097 SH   DFND   0 0 860,097
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 505,707 1,075,721 SH   DFND   0 0 1,075,721
ZOOMINFO TECHNOLOGIES INC COM CL A 98980F104 11,557 268,833 SH   DFND   0 0 268,833