The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 4,913 1,911,573 SH   SOLE   1,911,573 0 0
Akouos, Inc ADR 00973J101 34,650 1,515,073 SH   SOLE   1,515,073 0 0
Amarin Corp ADR 023111206 4,928 1,170,584 SH   SOLE   1,170,584 0 0
Ascendis Pharma A/S ADR 04351P101 171,276 1,109,874 SH   SOLE   1,109,874 0 0
Athira Pharma, Inc. COMM 04746L104 9,399 509,168 SH   SOLE   509,168 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 41,513 3,606,707 SH   SOLE   3,606,707 0 0
Chiasma COMM 16706W102 4,504 1,047,354 SH   SOLE   1,047,354 0 0
Coherus BioSciences COMM 19249H103 7,970 434,555 SH   SOLE   434,555 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 2,065 1,012,408 SH   SOLE   1,012,408 0 0
Galera Therapeutics, Inc COMM 36338D108 27,877 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 53,324 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 150,963 1,952,441 SH   SOLE   1,952,441 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 4,238 276,628 SH   SOLE   276,628 0 0
Merus N.V. COMM N5749R100 15,732 1,311,039 SH   SOLE   1,311,039 0 0
Natera COMM 632307104 223,984 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 23,512 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 28,952 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Biomed Ltd Ordinary Shares GBOOBYWYV 12,408 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 11,779 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 332 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 1,161 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 84,238 2,194,278 SH   SOLE   2,194,278 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 909 22,033 SH   SOLE   22,033 0 0
Abbvie Inc COMM 00287Y109 13,093 149,484 SH   SOLE   149,484 0 0
Acceleron Pharma Inc COMM 00434H108 2,933 26,066 SH   SOLE   26,066 0 0
Amgen Inc COMM 031162900 6,658 26,200 SH Call SOLE   26,200 0 0
Amgen Inc COMM 031162100 12,424 48,883 SH   SOLE   48,883 0 0
Applied Genetic Technologies Corp COMM 03820J100 1,755 361,172 SH   SOLE   361,172 0 0
Arena Pharmaceuticals Inc COMM 040047607 2,886 38,593 SH   SOLE   38,593 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 1,193 347,171 SH   SOLE   347,171 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 8,618 113,277 SH   SOLE   113,277 0 0
Calithera Biosciences Inc COMM 13089P101 748 216,907 SH   SOLE   216,907 0 0
ChemoCentryx Inc COMM 16383L106 1,949 35,572 SH   SOLE   35,572 0 0
Compugen Ltd COMM M25722105 1,068 65,705 SH   SOLE   65,705 0 0
Cytokinetics Inc COMM 23282W605 3,311 152,947 SH   SOLE   152,947 0 0
Cytokinetics Inc COMM 23282W955 3,157 145,800 SH Put SOLE   145,800 0 0
Lilly Eli & Co COMM 532457108 9,229 62,351 SH   SOLE   62,351 0 0
Fate Therapeutics Inc COMM 31189P102 724 18,126 SH   SOLE   18,126 0 0
GW Pharmaceuticals PLC ADR 36197T103 3,537 36,330 SH   SOLE   36,330 0 0
Homology Medicines Inc COMM 438083107 1,124 105,014 SH   SOLE   105,014 0 0
Immatics NV COMM N44445109 1,534 144,601 SH   SOLE   144,601 0 0
Insmed Inc COMM 457669307 8,659 269,405 SH   SOLE   269,405 0 0
Intra-Cellular Therapies Inc COMM 46116X101 5,657 220,465 SH   SOLE   220,465 0 0
Jazz Pharmaceuticals PLC COMM G50871105 8,137 57,063 SH   SOLE   57,063 0 0
Kadmon Holdings Inc COMM 48283N106 1,081 275,863 SH   SOLE   275,863 0 0
Kura Oncology Inc COMM 50127T109 3,024 98,683 SH   SOLE   98,683 0 0
Liquidia Technologies Inc COMM 53635D202 1,526 310,262 SH   SOLE   310,262 0 0
Marinus Pharmaceuticals Inc COMM 56854Q900 4,012 78,050 SH Call SOLE   78,050 0 0
Merck & Co Inc COMM 58933Y105 6,922 83,452 SH   SOLE   83,452 0 0
Mirum Pharmaceuticals Inc COMM 604749101 2,700 140,108 SH   SOLE   140,108 0 0
Moderna Inc COMM 60770K907 1,549 21,900 SH Call SOLE   21,900 0 0
MyoKardia Inc COMM 62857M105 2,925 21,452 SH   SOLE   21,452 0 0
Novocure Ltd COMM G6674U908 2,427 21,800 SH Call SOLE   21,800 0 0
Otonomy Inc COMM 68906L105 3,773 931,692 SH   SOLE   931,692 0 0
Ovid Therapeutics Inc COMM 690469101 2,780 484,280 SH   SOLE   484,280 0 0
PTC Therapeutics Inc COMM 69366J200 8,295 177,437 SH   SOLE   177,437 0 0
Protagonist Therapeutics Inc COMM 74366E102 3,072 157,159 SH   SOLE   157,159 0 0
Puma Biotechnology Inc COMM 74587V107 2,164 214,464 SH   SOLE   214,464 0 0
Reata Pharmaceuticals Inc COMM 75615P953 2,562 26,300 SH Put SOLE   26,300 0 0
Reata Pharmaceuticals Inc COMM 75615P103 2,927 30,043 SH   SOLE   30,043 0 0
Regenxbio Inc COMM 75901B107 718 26,078 SH   SOLE   26,078 0 0
Supernus Pharmaceuticals Inc COMM 868459108 3,014 144,647 SH   SOLE   144,647 0 0
TCR2 Therapeutics Inc COMM 87808K106 1,551 76,341 SH   SOLE   76,341 0 0
TG Therapeutics Inc COMM 88322Q108 2,931 109,545 SH   SOLE   109,545 0 0
United Therapeutics Corp COMM 91307C102 14,189 140,488 SH   SOLE   140,488 0 0
Zymeworks Inc COMM 98985W102 3,098 66,517 SH   SOLE   66,517 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 401 9,713 SH   OTR 1 9,713 0 0
Abbvie Inc COMM 00287Y109 5,774 65,922 SH   OTR 1 65,922 0 0
Acceleron Pharma Inc COMM 00434H108 1,295 11,509 SH   OTR 1 11,509 0 0
Amgen Inc COMM 031162900 28,948 11,100 SH Call OTR 1 11,600 0 0
Amgen Inc COMM 031162100 5,479 21,558 SH   OTR 1 21,558 0 0
Applied Genetic Technologies Corp COMM 03820J100 776 159,677 SH   OTR 1 159,677 0 0
Arena Pharmaceuticals Inc COMM 040047607 1,274 17,039 SH   OTR 1 17,039 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 527 153,281 SH   OTR 1 153,281 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 3,804 50,001 SH   OTR 1 50,001 0 0
Calithera Biosciences Inc COMM 13089P101 330 95,736 SH   OTR 1 95,736 0 0
ChemoCentryx Inc COMM 16383L106 861 15,712 SH   OTR 1 15,712 0 0
Compugen Ltd COMM M25722105 471 28,964 SH   OTR 1 28,964 0 0
Cytokinetics Inc COMM 23282W605 1,463 67,555 SH   OTR 1 67,555 0 0
Cytokinetics Inc COMM 23282W955 1,344 62,100 SH Put OTR 1 62,100 0 0
Lilly Eli & Co COMM 532457108 4,075 27,529 SH   OTR 1 27,529 0 0
Fate Therapeutics Inc COMM 31189P102 320 8,008 SH   OTR 1 8,008 0 0
GW Pharmaceuticals PLC ADR 36197T103 1,562 16,044 SH   OTR 1 16,044 0 0
Homology Medicines Inc COMM 438083107 495 46,292 SH   OTR 1 46,292 0 0
Immatics NV COMM N44445109 676 63,743 SH   OTR 1 63,743 0 0
Insmed Inc COMM 457669307 3,824 118,984 SH   OTR 1 118,984 0 0
Intra-Cellular Therapies Inc COMM 46116X101 2,498 97,338 SH   OTR 1 97,338 0 0
Jazz Pharmaceuticals PLC COMM G50871105 3,588 25,165 SH   OTR 1 25,165 0 0
Kadmon Holdings Inc COMM 48283N106 477 121,794 SH   OTR 1 121,794 0 0
Kadmon Holdings Inc Warrant 48283N114 137 240,091 SH   OTR 1 240,091 0 0
Kura Oncology Inc COMM 50127T109 1,333 43,519 SH   OTR 1 43,519 0 0
Liquidia Technologies Inc COMM 53635D202 576 117,160 SH   OTR 1 117,160 0 0
Marinus Pharmaceuticals Inc COMM 56854Q900 1,669 32,475 SH Call OTR 1 32,475 0 0
Merck & Co Inc COMM 58933Y105 3,053 36,802 SH   OTR 1 36,802 0 0
Mirum Pharmaceuticals Inc COMM 604749101 1,199 62,218 SH   OTR 1 62,218 0 0
Moderna Inc COMM 60770K907 686 9,700 SH Call OTR 1 9,700 0 0
MyoKardia Inc COMM 62857M105 1,291 9,471 SH   OTR 1 9,471 0 0
Novocure Ltd COMM G6674U908 1,069 9,600 SH Call OTR 1 9,600 0 0
Otonomy Inc COMM 68906L105 1,663 410,708 SH   OTR 1 410,708 0 0
Ovid Therapeutics Inc COMM 690469101 1,225 213,480 SH   OTR 1 213,480 0 0
PTC Therapeutics Inc COMM 69366J200 3,662 78,321 SH   OTR 1 78,321 0 0
Protagonist Therapeutics Inc COMM 74366E102 1,357 69,398 SH   OTR 1 69,398 0 0
Puma Biotechnology Inc COMM 74587V107 954 94,540 SH   OTR 1 94,540 0 0
Reata Pharmaceuticals Inc COMM 75615P953 1,130 11,600 SH Put OTR 1 11,600 0 0
Reata Pharmaceuticals Inc COMM 75615P103 1,292 13,264 SH   OTR 1 13,264 0 0
Regenxbio Inc COMM 75901B107 317 11,511 SH   OTR 1 11,511 0 0
Savara Inc COMM 805111101 152 139,507 SH   OTR 1 139,507 0 0
Supernus Pharmaceuticals Inc COMM 868459108 1,329 63,789 SH   OTR 1 63,789 0 0
TCR2 Therapeutics Inc COMM 87808K106 684 33,653 SH   OTR 1 33,653 0 0
TG Therapeutics Inc COMM 88322Q108 1,295 48,411 SH   OTR 1 48,411 0 0
United Therapeutics Corp COMM 91307C102 6,267 62,049 SH   OTR 1 62,049 0 0
Zymeworks Inc COMM 98985W102 1,368 29,365 SH   OTR 1 29,365 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 712 17,250 SH   OTR 2 17,250 0 0
Abbvie Inc COMM 00287Y109 11,031 125,934 SH   OTR 2 125,934 0 0
Acceleron Pharma Inc COMM 00434H108 2,472 21,971 SH   OTR 2 21,971 0 0
Amgen Inc COMM 031162900 5,642 22,200 SH Call OTR 2 22,200 0 0
Amgen Inc COMM 031162100 10,466 41,178 SH   OTR 2 41,178 0 0
Applied Genetic Technologies Corp COMM 03820J100 1,479 304,222 SH   OTR 2 304,222 0 0
Arena Pharmaceuticals Inc COMM 040047607 2,432 32,518 SH   OTR 2 32,518 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 1,005 292,602 SH   OTR 2 292,602 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 7,256 95,375 SH   OTR 2 95,375 0 0
Calithera Biosciences Inc COMM 13089P101 623 180,654 SH   OTR 2 180,654 0 0
ChemoCentryx Inc COMM 16383L106 1,641 29,951 SH   OTR 2 29,951 0 0
Compugen Ltd COMM M25722105 844 51,923 SH   OTR 2 51,923 0 0
Cytokinetics Inc COMM 23282W605 2,788 128,794 SH   OTR 2 128,794 0 0
Cytokinetics Inc COMM 23282W955 2,535 117,100 SH Put OTR 2 117,100 0 0
Lilly Eli & Co COMM 532457108 7,779 52,552 SH   OTR 2 52,552 0 0
Fate Therapeutics Inc COMM 31189P102 610 15,266 SH   OTR 2 15,266 0 0
GW Pharmaceuticals PLC ADR 36197T103 2,976 30,570 SH   OTR 2 30,570 0 0
Homology Medicines Inc COMM 438083107 928 86,709 SH   OTR 2 86,709 0 0
Immatics NV COMM N44445109 1,243 117,183 SH   OTR 2 117,183 0 0
Insmed Inc COMM 457669307 7,288 226,754 SH   OTR 2 226,754 0 0
Intra-Cellular Therapies Inc COMM 46116X101 4,766 185,752 SH   OTR 2 185,752 0 0
Jazz Pharmaceuticals PLC COMM G50871105 6,850 48,040 SH   OTR 2 48,040 0 0
Kadmon Holdings Inc COMM 48283N106 910 232,266 SH   OTR 2 232,266 0 0
Kura Oncology Inc COMM 50127T109 2,545 83,057 SH   OTR 2 83,057 0 0
Liquidia Technologies Inc COMM 53635D202 1,240 251,978 SH   OTR 2 251,978 0 0
Marinus Pharmaceuticals Inc COMM 56854Q900 3,314 64,475 SH Call OTR 2 64,475 0 0
Merck & Co Inc COMM 58933Y105 5,832 70,305 SH   OTR 2 70,305 0 0
Mirum Pharmaceuticals Inc COMM 604749101 2,292 118,926 SH   OTR 2 118,926 0 0
Moderna Inc COMM 60770K907 1,302 18,400 SH Call OTR 2 18,400 0 0
MyoKardia Inc COMM 62857M105 2,464 18,075 SH   OTR 2 18,075 0 0
Novocure Ltd COMM G6674U908 2,070 18,600 SH Call OTR 2 18,600 0 0
Otonomy Inc COMM 68906L105 3,115 769,196 SH   OTR 2 769,196 0 0
Ovid Therapeutics Inc COMM 690469101 2,295 399,861 SH   OTR 2 399,861 0 0
PTC Therapeutics Inc COMM 69366J200 6,984 149,394 SH   OTR 2 149,394 0 0
Protagonist Therapeutics Inc COMM 74366E102 2,565 131,212 SH   OTR 2 131,212 0 0
Puma Biotechnology Inc COMM 74587V107 1,685 166,978 SH   OTR 2 166,978 0 0
Reata Pharmaceuticals Inc COMM 75615P953 2,153 22,100 SH Put OTR 2 22,100 0 0
Reata Pharmaceuticals Inc COMM 75615P103 2,466 25,308 SH   OTR 2 25,308 0 0
Regenxbio Inc COMM 75901B107 603 21,918 SH   OTR 2 21,918 0 0
Savara Inc COMM 805111101 257 236,084 SH   OTR 2 236,084 0 0
Supernus Pharmaceuticals Inc COMM 868459108 2,540 121,859 SH   OTR 2 121,859 0 0
TCR2 Therapeutics Inc COMM 87808K106 1,281 63,034 SH   OTR 2 63,034 0 0
TG Therapeutics Inc COMM 88322Q108 2,474 92,445 SH   OTR 2 92,445 0 0
United Therapeutics Corp COMM 91307C102 11,961 118,422 SH   OTR 2 118,422 0 0
Zymeworks Inc COMM 98985W102 2,609 56,020 SH   OTR 2 56,020 0 0