The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 4,030 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
ABBVIE INC COM 00287Y109 43,795 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AC IMMUNE SA SHS H00263105 4,880 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 4,557 427,500 SH   DFND 1,2,3,4,5,6 427,500 0 0
ACCELERON PHARMA INC COM 00434H108 157,542 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 4,863 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ADC THERAPEUTICS SA SHS H0036K147 3,134 95,000 SH   DFND 1,2,3,4,5,6 95,000 0 0
ADICET BIO INC COM 007002108 1,538 129,335 SH   DFND 1,2,3,4,5,6 129,335 0 0
ADURO BIOTECH INC COM 00739L101 2,193 902,500 SH   DFND 1,2,3,4,5,6 902,500 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 18,540 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 7,409 1,045,000 SH   DFND 1,2,3,4,5,6 1,045,000 0 0
AGENUS INC COM NEW 00847G705 27,600 6,900,000 SH   DFND 1,2,3,4,5,6 6,900,000 0 0
ALBIREO PHARMA INC COM 01345P106 28,411 851,405 SH   DFND 1,2,3,4,5,6 851,405 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 124,942 425,000 SH   DFND 1,2,3,4,5,6 425,000 0 0
ALLOVIR INC COM 019818103 63,893 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 116,480 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 5,213 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 3,774 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 6,145 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 42,360 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 14,120 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
APPLE INC COM 037833100 23,162 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101 7,889 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
APTINYX INC COM 03836N103 5,077 1,502,035 SH   DFND 1,2,3,4,5,6 1,502,035 0 0
ARAVIVE INC COM 03890D108 6,163 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 85,109 324,200 SH   DFND 1,2,3,4,5,6 324,200 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 29,160 2,250,000 SH   DFND 1,2,3,4,5,6 2,250,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 14,730 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 3,317 285,000 SH   DFND 1,2,3,4,5,6 285,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 4,011 142,500 SH   DFND 1,2,3,4,5,6 142,500 0 0
AXCELLA HEALTH INC COM 05454B105 3,292 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 257,796 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 1,078 475,000 SH   DFND 1,2,3,4,5,6 475,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 11,412 150,000 SH Call DFND 1,2,3,4,5,6 150,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 17,308 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 102,544 1,481,214 SH   DFND 1,2,3,4 1,481,214 0 0
BIO-TECHNE CORP COM 09073M104 14,864 60,000 SH   DFND 1,2,3,4,5,6 60,000 0 0
BK OF AMERICA CORP COM 060505104 48,180 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 45,995 1,521,517 SH   DFND 1,2,3,4,5,6 1,521,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102 15,008 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
BRUKER CORP COM 116794108 6,967 175,275 SH   DFND 1,2,3,4,5,6 175,275 0 0
CARDIFF ONCOLOGY INC COM 14147L108 12,771 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
CHIASMA INC COM 16706W102 1,634 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
CIDARA THERAPEUTICS INC COM 171757107 640 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CITIGROUP INC COM NEW 172967424 21,555 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
CURIS INC COM NEW 231269200 1,644 1,404,729 SH   DFND 1,2,3,4,5,6 1,404,729 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 67 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 10,984 1,806,531 SH   DFND 1,2,3,4,5,6 1,806,531 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,188 178,600 SH   DFND 1,2,3,4,5,6 178,600 0 0
DANAHER CORPORATION COM 235851102 16,150 75,000 SH   DFND 1,2,3,4,5,6 75,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 30,780 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 14,332 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 7,470 370,000 SH   DFND 1,2,3,4,5,6 370,000 0 0
EPIZYME INC COM 29428V104 11,930 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9,293 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
EVELO BIOSCIENCES INC COM 299734103 2,503 475,000 SH   DFND 1,2,3,4,5,6 475,000 0 0
FATE THERAPEUTICS INC COM 31189P102 59,955 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
FIBROGEN INC COM 31572Q808 15,626 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 81,830 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
GENERAL MTRS CO COM 37045V100 14,795 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
GENERATION BIO CO COM 37148K100 86,987 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 175,849 875,000 SH Call DFND 1,2,3,4,5,6 875,000 0 0
GOSSAMER BIO INC COM 38341P102 29,275 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
HARPOON THERAPEUTICS INC COM 41358P106 13,592 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
HOOKIPA PHARMA INC COM 43906K100 5,678 599,616 SH   DFND 1,2,3,4,5,6 599,616 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 0 8 SH   DFND 1,2,3,4,5,6 8 0 0
IGM BIOSCIENCES INC COM 449585108 50,848 688,910 SH   DFND 1,2,3,4,5,6 688,910 0 0
I MAB SPONSORED ADS 44975P103 34,097 725,000 SH   DFND 1,2,3,4,5,6 725,000 0 0
IMMUNIC INC COM 4525EP101 14,856 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,777 190,000 SH   DFND 1,2,3,4,5,6 190,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 571,795 2,058,000 SH Put DFND 1,2,3,4,5,6 0 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 13,168 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 994 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 26,990 1,094,047 SH   DFND 1,2,3,4,5,6 1,094,047 0 0
JPMORGAN CHASE & CO COM 46625H100 96,270 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
KALEIDO BIOSCIENCES INC COM 483347100 5,541 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KE HLDGS INC SPONSORED ADS 482497104 53,331 870,000 SH   DFND 1,2,3,4,5,6 870,000 0 0
KRYSTAL BIOTECH INC COM 501147102 10,224 237,500 SH   DFND 1,2,3,4,5,6 237,500 0 0
KURA ONCOLOGY INC COM 50127T109 16,824 549,100 SH   DFND 1,2,3,4,5,6 549,100 0 0
KYMERA THERAPEUTICS INC COM 501575104 8,078 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 5,594 2,825,300 SH   DFND 1,2,3,4,5,6 2,825,300 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 5,063 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 81,683 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MEI PHARMA INC COM NEW 55279B202 2,371 760,000 SH   DFND 1,2,3,4,5,6 760,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 18,620 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MERUS N V COM N5749R100 3,000 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
METACRINE INC COM 59101E103 13,370 1,309,513 SH   DFND 1,2,3,4,5,6 1,309,513 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,417 760,000 SH   DFND 1,2,3,4,5,6 760,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 83,025 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MODERNA INC COM 60770K107 21,225 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
MORGAN STANLEY COM NEW 617446448 24,175 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 45,157 1,651,686 SH   DFND 1,2,3,4,5,6 1,651,686 0 0
NOVAGOLD RES INC COM NEW 66987E206 30,914 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
OCCIDENTAL PETE CORP COM 674599105 3,754 375,000 SH   DFND 1,2,3,4,5,6 375,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,445 351,500 SH   DFND 1,2,3,4,5,6 351,500 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 3,564 142,500 SH   DFND 1,2,3,4,5,6 142,500 0 0
OVID THERAPEUTICS INC COM 690469101 14,350 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PANDION THERAPEUTICS INC COM 698340106 1,662 145,000 SH   DFND 1,2,3,4,5,6 145,000 0 0
PASSAGE BIO INC COM 702712100 205 15,648 SH   DFND 1,2,3,4,5,6 15,648 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 7,100 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 3,082 302,750 SH   DFND 1,2,3,4,5,6 302,750 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 5,730 1,196,218 SH   DFND 1,2,3,4,5,6 1,196,218 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 2,600 133,000 SH   DFND 1,2,3,4,5,6 133,000 0 0
PROTHENA CORP PLC SHS G72800108 3,511 351,500 SH   DFND 1,2,3,4,5,6 351,500 0 0
REGENXBIO INC COM 75901B107 6,118 222,300 SH   DFND 1,2,3,4,5,6 222,300 0 0
RELAY THERAPEUTICS INC COM 75943R102 17,036 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 17,539 570,000 SH   DFND 1,2,3,4,5,6 570,000 0 0
REPLIMUNE GROUP INC COM 76029N106 16,114 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 771 321,100 SH   DFND 1,2,3,4,5,6 321,100 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 10,518 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 18,932 3,778,913 SH   DFND 1,2,3,4,5,6 3,778,913 0 0
SAGE THERAPEUTICS INC COM 78667J108 13,587 222,300 SH   DFND 1,2,3,4,5,6 222,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 44,139 2,495,140 SH   DFND 1,2,3,4,5,6 2,495,140 0 0
SCHRODINGER INC COM 80810D103 42,638 897,445 SH   DFND 1,2,3,4,5,6 897,445 0 0
SELECTA BIOSCIENCES INC COM 816212104 11,160 4,500,000 SH   DFND 1,2,3,4,5,6 4,500,000 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 1,498 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 38,490 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
SERES THERAPEUTICS INC COM 81750R102 8,493 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 3,471 1,710,000 SH   DFND 1,2,3,4,5,6 1,710,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 6,696 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 13,586 285,000 SH   DFND 1,2,3,4,5,6 285,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 9,067 270,750 SH   DFND 1,2,3,4,5,6 270,750 0 0
STONECO LTD COM CL A G85158106 21,156 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 4,115 465,500 SH   DFND 1,2,3,4,5,6 465,500 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 25,556 1,140,882 SH   DFND 1,2,3,4,5,6 1,140,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 10,160 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
TG THERAPEUTICS INC COM 88322Q108 40,140 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 19,054 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 21,315 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 17,750 570,000 SH   DFND 1,2,3,4,5,6 570,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 28,392 325,000 SH   DFND 1,2,3,4,5,6 325,000 0 0
UNIQURE NV SHS N90064101 27,623 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
VAXART INC COM NEW 92243A200 4,988 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
WW INTL INC COM 98262P101 279,621 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 10,942 285,028 SH   DFND 1,2,3,4,5,6 285,028 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 2,857 87,400 SH   DFND 1,2,3,4,5,6 87,400 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 20,318 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0