The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABB LTD SPONSORED ADR 000375204 255,035 10,008,065 SH   DFND 1, 2 10,008,065 0 0
AES CORP COM 00130H105 406,556 22,451,436 SH   DFND 1, 2 22,451,436 0 0
ASGN INC COM 00191U102 62,081 976,725 SH   DFND 1, 2 976,725 0 0
ABBOTT LABS COM 002824100 6,091,304 55,977,647 SH   DFND 1, 2 55,953,592 0 24,055
ABBVIE INC COM 00287Y109 875,558 9,996,100 SH   DFND 1, 2 9,996,100 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,637,203 32,578,869 SH   DFND 1, 2 32,566,172 0 12,697
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 84,069 1,728,750 SH   DFND 1, 2 1,728,750 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 10,543 1,321,200 SH   DFND 1, 2 1,321,200 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,279,484 2,608,948 SH   DFND 1, 2 2,608,948 0 0
AGNICO EAGLE MINES LTD COM 008474108 344 4,325 SH   DFND 1, 2 4,325 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 120,237 3,435,353 SH   DFND 1, 2 3,435,353 0 0
AIR LEASE CORP CL A 00912X302 398,107 13,531,861 SH   DFND 1, 2 13,531,861 0 0
AIR PRODS & CHEMS INC COM 009158106 1,761,448 5,913,903 SH   DFND 1, 2 5,913,903 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 56,128 191,025 SH   DFND 1, 2 189,314 0 1,711
ALLAKOS INC COM 01671P100 292,039 3,585,500 SH   DFND 1, 2 3,585,500 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 73,640 8,444,905 SH   DFND 1, 2 8,444,905 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 273,940 7,264,389 SH   DFND 1, 2 7,264,389 0 0
ALPHABET INC CAP STK CL C 02079K107 5,982,827 4,071,062 SH   DFND 1, 2 4,069,981 0 1,081
ALPHABET INC CAP STK CL A 02079K305 2,601,341 1,774,932 SH   DFND 1, 2 1,774,932 0 0
ALTERYX INC COM CL A 02156B103 86,422 761,091 SH   DFND 1, 2 761,091 0 0
ALTRIA GROUP INC COM 02209S103 710,819 18,397,198 SH   DFND 1, 2 18,396,761 0 437
AMAZON COM INC COM 023135106 11,143,508 3,539,076 SH   DFND 1, 2 3,539,076 0 0
AMBEV SA SPONSORED ADR 02319V103 2,550 1,128,200 SH   DFND 1, 2 1,128,200 0 0
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 828,411 66,352,480 SH   DFND 1, 2 66,275,504 0 76,976
AMERICAN INTL GROUP INC COM NEW 026874784 83,203 3,022,269 SH   DFND 1, 2 3,022,269 0 0
AMERICAN TOWER CORP NEW COM 03027X100 1,093,367 4,524,120 SH   DFND 1, 2 4,522,925 0 1,195
AMERISOURCEBERGEN CORP COM 03073E105 186,074 1,919,868 SH   DFND 1, 2 1,919,868 0 0
AMETEK INC COM 031100100 177,942 1,789,366 SH   DFND 1, 2 1,788,199 0 1,167
AMGEN INC COM 031162100 787,904 3,100,032 SH   DFND 1, 2 3,100,032 0 0
AMPHENOL CORP NEW CL A 032095101 293,107 2,707,183 SH   DFND 1, 2 2,706,735 0 448
ANALOG DEVICES INC COM 032654105 196,085 1,679,674 SH   DFND 1, 2 1,679,673 0 1
ANGLOGOLD ASHANTI LIMITED SPONSORED ADR 035128206 223,856 8,485,818 SH   DFND 1, 2 8,485,818 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 315,244 5,844,557 SH   DFND 1, 2 5,823,514 0 21,043
ANTHEM INC COM 036752103 1,281,386 4,772,040 SH   DFND 1, 2 4,764,960 0 7,080
APOLLO GLOBAL MGMT INC COM CL A 03768E105 248,301 5,548,625 SH   DFND 1, 2 5,548,625 0 0
APPLE INC COM 037833100 1,869,804 16,150,321 SH   DFND 1, 2 16,149,124 0 1,197
APPFOLIO INC COM CL A 03783C100 7,658 54,000 SH   DFND 1, 2 54,000 0 0
APPLIED MATLS INC COM 038222105 1,127,403 18,963,858 SH   DFND 1, 2 18,956,926 0 6,932
APPLIED MOLECULAR TRANS INC COM 03824M109 20,852 655,300 SH   DFND 1, 2 655,300 0 0
ARAMARK COM 03852U106 316,992 11,984,590 SH   DFND 1, 2 11,984,590 0 0
ARCOSA INC COM 039653100 80,283 1,820,900 SH   DFND 1, 2 1,820,900 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 266,244 6,586,942 SH   DFND 1, 2 6,586,942 0 0
ARMSTRONG WORLD INDS INC COM 04247X102 396,451 5,761,526 SH   DFND 1, 2 5,761,526 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,603,866 29,249,466 SH   DFND 1, 2 29,185,493 0 63,973
AUTODESK INC COM 052769106 55,419 239,899 SH   DFND 1, 2 239,899 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 14,232 1,222,688 SH   DFND 1, 2 1,222,688 0 0
AVALARA INC COM 05338G106 19,188 150,683 SH   DFND 1, 2 150,683 0 0
AVALONBAY CMNTYS INC COM 053484101 266,227 1,782,690 SH   DFND 1, 2 1,782,690 0 0
AZUL S A SPONSR ADR PFD 05501U106 4,046 307,473 SH   DFND 1, 2 307,473 0 0
BCE INC COM NEW 05534B760 41,550 1,001,928 SH   DFND 1, 2 1,001,928 0 0
BWX TECHNOLOGIES INC COM 05605H100 418,252 7,427,659 SH   DFND 1, 2 7,427,659 0 0
BAKER HUGHES COMPANY CL A 05722G100 29,212 2,198,027 SH   DFND 1, 2 2,198,027 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 2,974 1,101,514 SH   DFND 1, 2 1,101,514 0 0
BK OF AMERICA CORP COM 060505104 342,482 14,216,779 SH   DFND 1, 2 14,216,779 0 0
BANK NEW YORK MELLON CORP COM 064058100 406,557 11,839,162 SH   DFND 1, 2 11,839,162 0 0
BARRICK GOLD CORP COM 067901108 269,929 9,602,477 SH   DFND 1, 2 9,602,477 0 0
BAXTER INTL INC COM 071813109 961,553 11,957,557 SH   DFND 1, 2 11,957,557 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1,706,943 5,962,380 SH   DFND 1, 2 5,958,045 0 4,335
BERKELEY LTS INC COM 084310101 18,992 248,712 SH   DFND 1, 2 248,712 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 18,240 57 SH   DFND 1, 2 57 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 954,795 4,483,896 SH   DFND 1, 2 4,481,610 0 2,286
BIGCOMMERCE HLDGS INC COM SER 1 08975P108 20,825 250,000 SH   DFND 1, 2 250,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 41,519 545,725 SH   DFND 1, 2 543,613 0 2,112
BLACKROCK INC COM 09247X101 1,679,710 2,980,643 SH   DFND 1, 2 2,977,094 0 3,549
BLACKSTONE GROUP INC COM CL A 09260D107 884,751 16,949,251 SH   DFND 1, 2 16,949,251 0 0
BLUEBIRD BIO INC COM 09609G100 60,822 1,127,382 SH   DFND 1, 2 1,127,382 0 0
BOEING CO COM 097023105 290,646 1,758,717 SH   DFND 1, 2 1,758,687 0 30
BOOKING HOLDINGS INC COM 09857L108 1,111,897 649,974 SH   DFND 1, 2 649,974 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100 33,190 218,300 SH   DFND 1, 2 218,300 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 457,240 12,685,663 SH   DFND 1, 2 12,671,128 0 14,535
BROADCOM INC COM 11135F101 12,536,963 34,411,980 SH   DFND 1, 2 34,393,620 0 18,360
BURLINGTON STORES INC COM 122017106 468,604 2,273,792 SH   DFND 1, 2 2,272,703 0 1,089
CDK GLOBAL INC COM 12508E101 337,554 7,743,850 SH   DFND 1, 2 7,743,850 0 0
CIGNA CORP NEW COM 125523100 499,418 2,948,773 SH   DFND 1, 2 2,948,773 0 0
CME GROUP INC COM 12572Q105 1,829,017 10,932,713 SH   DFND 1, 2 10,929,022 0 3,691
CMS ENERGY CORP COM 125896100 488,989 7,963,419 SH   DFND 1, 2 7,956,189 0 7,230
CSX CORP COM 126408103 888,060 11,434,033 SH   DFND 1, 2 11,416,134 0 17,899
CVS HEALTH CORP COM 126650100 783,192 13,411,118 SH   DFND 1, 2 13,391,427 0 19,691
CABLE ONE INC COM 12685J105 302,201 160,792 SH   DFND 1, 2 160,792 0 0
CABOT MICROELECTRONICS CORP COM 12709P103 90,851 636,169 SH   DFND 1, 2 636,169 0 0
CACTUS INC CL A 127203107 23,986 1,249,900 SH   DFND 1, 2 1,249,900 0 0
CANADIAN NATL RY CO COM 136375102 112,566 1,057,367 SH   DFND 1, 2 1,057,367 0 0
CANADIAN NAT RES LTD COM 136385101 262,948 16,407,776 SH   DFND 1, 2 16,407,776 0 0
CANNAE HLDGS INC COM 13765N107 13,190 353,987 SH   DFND 1, 2 353,987 0 0
CARDINAL HEALTH INC COM 14149Y108 37,420 797,019 SH   DFND 1, 2 797,019 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 47,359 3,119,809 SH   DFND 1, 2 3,119,809 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 914,966 29,959,593 SH   DFND 1, 2 29,959,287 0 306
CATERPILLAR INC DEL COM 149123101 1,195,123 8,012,892 SH   DFND 1, 2 8,012,892 0 0
CELANESE CORP DEL COM 150870103 845,267 7,866,635 SH   DFND 1, 2 7,862,167 0 4,468
CELLECTIS S A SPON ADS 15117K103 24,778 1,339,336 SH   DFND 1, 2 1,339,336 0 0
CENTENE CORP DEL COM 15135B101 1,385,040 23,745,095 SH   DFND 1, 2 23,740,666 0 4,429
CENTERPOINT ENERGY INC COM 15189T107 388,635 20,084,511 SH   DFND 1, 2 20,084,511 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 6,412,104 10,270,068 SH   DFND 1, 2 10,268,787 0 1,281
CHEVRON CORP NEW COM 166764100 2,101,237 29,184,351 SH   DFND 1, 2 29,174,092 0 10,259
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,131,060 909,236 SH   DFND 1, 2 909,236 0 0
CHURCH & DWIGHT INC COM 171340102 1,332,899 14,223,657 SH   DFND 1, 2 14,223,657 0 0
CISCO SYS INC COM 17275R102 260,185 6,605,347 SH   DFND 1, 2 6,605,347 0 0
CITIZENS FINL GROUP INC COM 174610105 609,548 24,118,092 SH   DFND 1, 2 24,118,092 0 0
CLOROX CO DEL COM 189054109 6,019 28,606 SH   DFND 1, 2 28,606 0 0
CLOUDERA INC COM 18914U100 3,228 296,400 SH   DFND 1, 2 296,400 0 0
COCA COLA CO COM 191216100 621,759 12,596,077 SH   DFND 1, 2 12,545,161 0 50,916
COGNEX CORP COM 192422103 34,503 530,000 SH   DFND 1, 2 530,000 0 0
COLGATE PALMOLIVE CO COM 194162103 76,848 996,081 SH   DFND 1, 2 996,081 0 0
COMCAST CORP NEW CL A 20030N101 9,649,410 208,591,834 SH   DFND 1, 2 208,458,177 0 133,657
CONCHO RES INC COM 20605P101 368,986 8,363,180 SH   DFND 1, 2 8,356,209 0 6,971
CONOCOPHILLIPS COM 20825C104 1,145,234 34,874,182 SH   DFND 1, 2 34,874,179 0 3
CONSTELLATION BRANDS INC CL A 21036P108 173,854 917,388 SH   DFND 1, 2 917,388 0 0
CORTEXYME INC COM 22053A107 127,953 2,559,067 SH   DFND 1, 2 2,559,067 0 0
COSTCO WHSL CORP NEW COM 22160K105 1,808,066 5,093,792 SH   DFND 1, 2 5,089,064 0 4,728
COUSINS PPTYS INC COM NEW 222795502 16,904 591,253 SH   DFND 1, 2 591,253 0 0
CREE INC COM 225447101 359,918 5,646,653 SH   DFND 1, 2 5,646,653 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 2,426,992 14,580,987 SH   DFND 1, 2 14,580,536 0 451
CUMMINS INC COM 231021106 88,106 417,249 SH   DFND 1, 2 417,249 0 0
DANAHER CORPORATION COM 235851102 1,366,229 6,346,912 SH   DFND 1, 2 6,346,912 0 0
DARDEN RESTAURANTS INC COM 237194105 675,682 6,707,186 SH   DFND 1, 2 6,707,186 0 0
DEERE & CO COM 244199105 571,735 2,580,061 SH   DFND 1, 2 2,580,061 0 0
DEL TACO RESTAURANTS INC NEW COM 245496104 11,793 1,438,200 SH   DFND 1, 2 1,438,200 0 0
DEXCOM INC COM 252131107 72,292 175,367 SH   DFND 1, 2 175,367 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 62,468 458,932 SH   DFND 1, 2 458,932 0 0
DIGITAL RLTY TR INC COM 253868103 1,047,279 7,135,651 SH   DFND 1, 2 7,132,064 0 3,587
DOMINION ENERGY INC UNIT 99/99/9999 25746U133 54,370 534,300 SH   DFND 1, 2 534,300 0 0
DOMINOS PIZZA INC COM 25754A201 8,335 19,600 SH   DFND 1, 2 19,600 0 0
DOW INC COM 260557103 1,780,426 37,842,448 SH   DFND 1, 2 37,804,279 0 38,169
DUN & BRADSTREET HLDGS INC COM 26484T106 186,291 7,259,980 SH   DFND 1, 2 7,259,980 0 0
DUPONT DE NEMOURS INC COM 26614N102 197,707 3,563,579 SH   DFND 1, 2 3,563,579 0 0
EOG RES INC COM 26875P101 1,655,291 46,056,245 SH   DFND 1, 2 46,047,434 0 8,811
EAST WEST BANCORP INC COM 27579R104 393,409 12,017,853 SH   DFND 1, 2 12,017,853 0 0
EATON VANCE CORP COM NON VTG 278265103 41,572 1,089,704 SH   DFND 1, 2 1,089,704 0 0
EDISON INTL COM 281020107 782,984 15,400,506 SH   DFND 1, 2 15,399,738 0 768
EDWARDS LIFESCIENCES CORP COM 28176E108 1,394,736 17,475,190 SH   DFND 1, 2 17,475,190 0 0
ELECTRONIC ARTS INC COM 285512109 170,178 1,305,041 SH   DFND 1, 2 1,305,041 0 0
ENBRIDGE INC COM 29250N105 2,499,572 85,568,935 SH   DFND 1, 2 85,460,009 0 108,926
ENDAVA PLC ADS 29260V105 20,347 322,200 SH   DFND 1, 2 322,200 0 0
EPAM SYS INC COM 29414B104 108,331 335,099 SH   DFND 1, 2 335,099 0 0
EQUIFAX INC COM 294429105 1,304,644 8,315,097 SH   DFND 1, 2 8,309,563 0 5,534
EQUINIX INC COM 29444U700 1,788,001 2,352,013 SH   DFND 1, 2 2,350,863 0 1,150
EQUITRANS MIDSTREAM CORP COM 294600101 373,909 44,171,343 SH   DFND 1, 2 44,171,343 0 0
EURONET WORLDWIDE INC COM 298736109 81,743 897,290 SH   DFND 1, 2 897,290 0 0
EVERTEC INC COM 30040P103 36,008 1,037,390 SH   DFND 1, 2 1,037,390 0 0
EXELON CORP COM 30161N101 1,037,662 29,017,404 SH   DFND 1, 2 29,017,404 0 0
EXTRA SPACE STORAGE INC COM 30225T102 191,197 1,787,052 SH   DFND 1, 2 1,787,052 0 0
FTI CONSULTING INC COM 302941109 72,674 685,800 SH   DFND 1, 2 685,800 0 0
FACEBOOK INC CL A 30303M102 13,037,369 49,779,984 SH   DFND 1, 2 49,761,111 0 18,873
FAIR ISAAC CORP COM 303250104 12,379 29,100 SH   DFND 1, 2 29,100 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 2,410,214 16,372,621 SH   DFND 1, 2 16,372,619 0 2
FIRST REP BK SAN FRANCISCO C COM 33616C100 912,054 8,362,897 SH   DFND 1, 2 8,360,619 0 2,278
FLEETCOR TECHNOLOGIES INC COM 339041105 1,030,272 4,327,054 SH   DFND 1, 2 4,327,054 0 0
FORTIS INC COM 349553107 384 9,400 SH   DFND 1, 2 9,400 0 0
FOX CORP CL A COM 35137L105 13,182 473,666 SH   DFND 1, 2 473,666 0 0
FRANCO NEV CORP COM 351858105 57,974 415,344 SH   DFND 1, 2 415,344 0 0
GCI LIBERTY INC COM CLASS A 36164V305 42,608 519,868 SH   DFND 1, 2 519,868 0 0
GALAPAGOS NV SPON ADR 36315X101 38,249 269,837 SH   DFND 1, 2 269,837 0 0
GALLAGHER ARTHUR J & CO COM 363576109 453,617 4,296,767 SH   DFND 1, 2 4,296,767 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 270,676 7,329,603 SH   DFND 1, 2 7,329,585 0 18
GENERAC HLDGS INC COM 368736104 157,080 811,197 SH   DFND 1, 2 811,197 0 0
GENERAL DYNAMICS CORP COM 369550108 171,602 1,239,628 SH   DFND 1, 2 1,239,628 0 0
GENERAL MLS INC COM 370334104 767,884 12,449,487 SH   DFND 1, 2 12,449,487 0 0
GENMAB A/S SPONSORED ADS 372303206 94,605 2,534,892 SH   DFND 1, 2 2,534,892 0 0
GERDAU SA SPON ADR REP PFD 373737105 474,655 128,285,076 SH   DFND 1, 2 128,285,076 0 0
GILEAD SCIENCES INC COM 375558103 3,066,528 48,533,977 SH   DFND 1, 2 48,506,101 0 27,876
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 621,191 16,505,150 SH   DFND 1, 2 16,503,779 0 1,371
GLOBAL PMTS INC COM 37940X102 323,106 1,819,535 SH   DFND 1, 2 1,819,535 0 0
GODADDY INC CL A 380237107 700,732 9,223,251 SH   DFND 1, 2 9,213,417 0 9,834
GOL LINHAS AEREAS INTELIGENT SPON ADR PFD NEW 38045R206 6,381 1,046,096 SH   DFND 1, 2 1,046,096 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 224,730 1,118,229 SH   DFND 1, 2 1,118,229 0 0
GOODRX HLDGS INC COM CL A 38246G108 83,400 1,500,000 SH   DFND 1, 2 1,500,000 0 0
GOSSAMER BIO INC COM 38341P102 57,627 4,643,561 SH   DFND 1, 2 4,643,561 0 0
GRACO INC COM 384109104 25,767 420,000 SH   DFND 1, 2 420,000 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 24,113 1,420,351 SH   DFND 1, 2 1,420,351 0 0
GROCERY OUTLET HLDG CORP COM 39874R101 142,604 3,626,753 SH   DFND 1, 2 3,626,753 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 30,498 620,564 SH   DFND 1, 2 612,519 0 8,045
HALLIBURTON CO COM 406216101 11,090 920,300 SH   DFND 1, 2 920,300 0 0
HASBRO INC COM 418056107 93,054 1,124,930 SH   DFND 1, 2 1,124,780 0 150
HEALTH CATALYST INC COM 42225T107 48,888 1,335,737 SH   DFND 1, 2 1,335,737 0 0
HEICO CORP NEW COM 422806109 112,639 1,076,242 SH   DFND 1, 2 1,076,242 0 0
HEICO CORP NEW CL A 422806208 63,199 712,799 SH   DFND 1, 2 712,799 0 0
HENRY JACK & ASSOC INC COM 426281101 38,376 236,496 SH   DFND 1, 2 236,496 0 0
HESS CORP COM 42809H107 61,479 1,502,058 SH   DFND 1, 2 1,502,058 0 0
HILTON GRAND VACATIONS INC COM 43283X105 142,442 6,789,407 SH   DFND 1, 2 6,789,407 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 684,065 8,017,414 SH   DFND 1, 2 8,008,778 0 8,636
HOME DEPOT INC COM 437076102 263,897 950,268 SH   DFND 1, 2 950,111 0 157
HONEYWELL INTL INC COM 438516106 913,557 5,549,851 SH   DFND 1, 2 5,539,115 0 10,736
HORMEL FOODS CORP COM 440452100 599,051 12,253,897 SH   DFND 1, 2 12,217,491 0 36,406
HUAZHU GROUP LTD SPONSORED ADS 44332N106 32,869 760,158 SH   DFND 1, 2 760,158 0 0
HUBSPOT INC COM 443573100 417,864 1,429,914 SH   DFND 1, 2 1,429,914 0 0
HUMANA INC COM 444859102 1,709,652 4,131,539 SH   DFND 1, 2 4,124,059 0 7,480
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 145,146 4,507,442 SH   DFND 1, 2 4,507,442 0 0
HUYA INC ADS REP SHS A 44852D108 66,332 2,769,622 SH   DFND 1, 2 2,769,622 0 0
ICICI BANK LIMITED ADR 45104G104 288,298 29,327,966 SH   DFND 1, 2 29,100,836 0 227,130
IDEXX LABS INC COM 45168D104 75,466 191,972 SH   DFND 1, 2 191,972 0 0
INARI MED INC COM 45332Y109 31,059 450,000 SH   DFND 1, 2 450,000 0 0
INCYTE CORP COM 45337C102 663,177 7,390,123 SH   DFND 1, 2 7,384,446 0 5,677
INFOSYS LTD SPONSORED ADR 456788108 281,985 20,421,179 SH   DFND 1, 2 20,293,450 0 127,729
INSULET CORP COM 45784P101 70,949 299,883 SH   DFND 1, 2 299,883 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 9,123 193,200 SH   DFND 1, 2 193,200 0 0
INTEL CORP COM 458140100 5,168,121 99,815,578 SH   DFND 1, 2 99,752,903 0 62,675
INTERCONTINENTAL EXCHANGE IN COM 45866F104 2,245,999 22,450,757 SH   DFND 1, 2 22,431,947 0 18,810
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 464,417 3,792,716 SH   DFND 1, 2 3,792,269 0 447
INTUIT COM 461202103 59,640 182,826 SH   DFND 1, 2 182,826 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 65,085 91,728 SH   DFND 1, 2 91,728 0 0
IRIDIUM COMMUNICATIONS INC COM 46269C102 163,421 6,388,639 SH   DFND 1, 2 6,388,639 0 0
ISHARES TR MSCI EAFE ETF 464287465 9,329 145,860 SH   DFND 1, 2 145,628 0 232
ISHARES TR RUS 1000 VAL ETF 464287598 658 5,611 SH   DFND 1, 2 0 0 5,611
ISHARES TR RUS 1000 ETF 464287622 2,090 11,253 SH   DFND 1, 2 11,253 0 0
ISHARES TR MSCI ACWI ETF 464288257 1,468 18,456 SH   DFND 1, 2 18,438 0 18
JPMORGAN CHASE & CO COM 46625H100 3,267,780 33,947,010 SH   DFND 1, 2 33,931,122 0 15,888
JACOBS ENGR GROUP INC COM 469814107 371,595 4,005,551 SH   DFND 1, 2 4,005,551 0 0
JAMF HLDG CORP COM 47074L105 9,403 250,000 SH   DFND 1, 2 250,000 0 0
JOHNSON & JOHNSON COM 478160104 2,718,556 18,260,356 SH   DFND 1, 2 18,238,366 0 21,990
KLA CORP COM NEW 482480100 1,772,745 9,150,317 SH   DFND 1, 2 9,150,317 0 0
KKR & CO INC COM 48251W104 778,630 22,674,142 SH   DFND 1, 2 22,674,142 0 0
KT CORP SPONSORED ADR 48268K101 93,256 9,704,072 SH   DFND 1, 2 9,704,072 0 0
KARUNA THERAPEUTICS INC COM 48576A100 35,992 465,500 SH   DFND 1, 2 465,500 0 0
KEURIG DR PEPPER INC COM 49271V100 1,001,503 36,286,394 SH   DFND 1, 2 36,284,824 0 1,570
KEYCORP COM 493267108 738,372 61,892,010 SH   DFND 1, 2 61,892,010 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 60,491 1,281,126 SH   DFND 1, 2 1,281,126 0 0
KRAFT HEINZ CO COM 500754106 220,927 7,376,525 SH   DFND 1, 2 7,376,525 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 65,106 3,376,853 SH   DFND 1, 2 3,376,853 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 1,025,733 6,039,388 SH   DFND 1, 2 6,039,070 0 318
LAMB WESTON HLDGS INC COM 513272104 282,617 4,264,640 SH   DFND 1, 2 4,264,139 0 501
LAS VEGAS SANDS CORP COM 517834107 166,382 3,565,547 SH   DFND 1, 2 3,565,547 0 0
LAUDER ESTEE COS INC CL A 518439104 387,904 1,778,111 SH   DFND 1, 2 1,778,111 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 21,411 693,588 SH   DFND 1, 2 693,588 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 33,815 236,682 SH   DFND 1, 2 236,682 0 0
LIGHTSPEED POS INC SUB VTG SHS 53227R106 24,904 777,695 SH   DFND 1, 2 777,695 0 0
LILLY ELI & CO COM 532457108 2,388,287 16,136,691 SH   DFND 1, 2 16,132,973 0 3,718
LIVERAMP HLDGS INC COM 53815P108 145,287 2,806,387 SH   DFND 1, 2 2,806,387 0 0
LIVONGO HEALTH INC COM 539183103 11,974 85,500 SH   DFND 1, 2 85,500 0 0
LOCKHEED MARTIN CORP COM 539830109 962,027 2,509,823 SH   DFND 1, 2 2,509,662 0 161
LOMA NEGRA CORP SPONSORED ADS 54150E104 36,046 8,363,411 SH   DFND 1, 2 8,363,411 0 0
MKS INSTRS INC COM 55306N104 415,488 3,803,788 SH   DFND 1, 2 3,803,788 0 0
MSCI INC COM 55354G100 464,289 1,301,370 SH   DFND 1, 2 1,301,370 0 0
MANULIFE FINL CORP COM 56501R106 154 11,100 SH   DFND 1, 2 11,100 0 0
MARKETAXESS HLDGS INC COM 57060D108 85,675 177,900 SH   DFND 1, 2 177,900 0 0
MARSH & MCLENNAN COS INC COM 571748102 2,496,341 21,765,720 SH   DFND 1, 2 21,740,307 0 25,413
MARRIOTT INTL INC NEW CL A 571903202 192,420 2,078,422 SH   DFND 1, 2 2,078,422 0 0
MASTERCARD INCORPORATED CL A 57636Q104 2,959,068 8,750,239 SH   DFND 1, 2 8,750,087 0 152
MATTEL INC COM 577081102 46,112 3,941,175 SH   DFND 1, 2 3,941,175 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 160,225 2,369,849 SH   DFND 1, 2 2,369,849 0 0
MERCADOLIBRE INC COM 58733R102 586,845 542,112 SH   DFND 1, 2 542,112 0 0
MERCK & CO. INC COM 58933Y105 3,169,561 38,213,851 SH   DFND 1, 2 38,198,364 0 15,487
METTLER TOLEDO INTERNATIONAL COM 592688105 412,762 427,400 SH   DFND 1, 2 427,400 0 0
MICROSOFT CORP COM 594918104 19,896,349 94,601,027 SH   DFND 1, 2 94,560,413 0 40,614
MICRON TECHNOLOGY INC COM 595112103 920,804 19,607,616 SH   DFND 1, 2 19,599,975 0 7,641
MOLINA HEALTHCARE INC COM 60855R100 141,904 775,261 SH   DFND 1, 2 775,261 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 99,210 2,956,204 SH   DFND 1, 2 2,956,204 0 0
MONDELEZ INTL INC CL A 609207105 1,338,612 23,302,355 SH   DFND 1, 2 23,302,355 0 0
MONGODB INC CL A 60937P106 188,931 816,080 SH   DFND 1, 2 816,080 0 0
MOODYS CORP COM 615369105 1,531,390 5,284,386 SH   DFND 1, 2 5,282,208 0 2,178
MOSAIC CO NEW COM 61945C103 90,028 4,927,645 SH   DFND 1, 2 4,927,645 0 0
MURPHY OIL CORP COM 626717102 9,305 1,043,200 SH   DFND 1, 2 1,043,200 0 0
NASDAQ INC COM 631103108 232,490 1,894,626 SH   DFND 1, 2 1,894,626 0 0
NATIONAL GRID PLC SPONSORED ADR NE 636274409 9,421 165,603 SH   DFND 1, 2 165,603 0 0
NCINO INC COM 63947U107 13,346 167,500 SH   DFND 1, 2 167,500 0 0
NETAPP INC COM 64110D104 1,160,362 26,467,846 SH   DFND 1, 2 26,467,846 0 0
NETFLIX INC COM 64110L106 8,101,326 16,201,903 SH   DFND 1, 2 16,198,433 0 3,470
NETEASE INC SPONSORED ADS 64110W102 6,123 13,468 SH   DFND 1, 2 13,468 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 411,206 4,275,476 SH   DFND 1, 2 4,275,476 0 0
NEWMONT CORP COM 651639106 74,529 1,174,604 SH   DFND 1, 2 1,174,604 0 0
NEXTERA ENERGY INC COM 65339F101 371,915 1,339,915 SH   DFND 1, 2 1,338,520 0 1,395
NEXTERA ENERGY INC UNIT 09/01/2022S 65339F796 77,436 1,429,759 SH   DFND 1, 2 1,429,759 0 0
NIKE INC CL B 654106103 933,034 7,431,416 SH   DFND 1, 2 7,427,854 0 3,562
NOBLE ENERGY INC COM 655044105 125,984 14,735,000 SH   DFND 1, 2 14,735,000 0 0
NORFOLK SOUTHN CORP COM 655844108 1,393,260 6,510,804 SH   DFND 1, 2 6,503,640 0 7,164
NORTHROP GRUMMAN CORP COM 666807102 4,759,782 15,083,838 SH   DFND 1, 2 15,070,613 0 13,225
NOVARTIS AG SPONSORED ADR 66987V109 67,872 780,185 SH   DFND 1, 2 780,185 0 0
NOVANTA INC COM 67000B104 35,321 335,300 SH   DFND 1, 2 335,300 0 0
NOVO-NORDISK A S ADR 670100205 319,972 4,581,821 SH   DFND 1, 2 4,568,532 0 13,289
NUCANA PLC SPONSORED ADR 67022C106 22,837 4,417,153 SH   DFND 1, 2 4,417,153 0 0
NUCOR CORP COM 670346105 212,746 4,742,444 SH   DFND 1, 2 4,738,827 0 3,617
OAK STR HEALTH INC COM 67181A107 53,440 1,000,000 SH   DFND 1, 2 1,000,000 0 0
OKTA INC CL A 679295105 95,965 448,751 SH   DFND 1, 2 448,751 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 227,482 1,257,364 SH   DFND 1, 2 1,257,364 0 0
ON SEMICONDUCTOR CORP COM 682189105 382,066 17,614,868 SH   DFND 1, 2 17,614,868 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 85,182 3,999,141 SH   DFND 1, 2 3,999,141 0 0
OTIS WORLDWIDE CORP COM 68902V107 70,210 1,124,799 SH   DFND 1, 2 1,124,799 0 0
PG&E CORP COM 69331C108 65,163 6,939,582 SH   DFND 1, 2 6,939,582 0 0
PNC FINL SVCS GROUP INC COM 693475105 1,697,456 15,446,046 SH   DFND 1, 2 15,431,554 0 14,492
PPG INDS INC COM 693506107 538,371 4,409,984 SH   DFND 1, 2 4,409,984 0 0
PPL CORP COM 69351T106 14,234 523,133 SH   DFND 1, 2 523,133 0 0
PACCAR INC COM 693718108 222,718 2,611,606 SH   DFND 1, 2 2,611,606 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 106,002 10,739,832 SH   DFND 1, 2 10,739,832 0 0
PARK HOTELS RESORTS INC COM 700517105 88,991 8,907,994 SH   DFND 1, 2 8,907,994 0 0
PAYCHEX INC COM 704326107 1,195,204 14,983,505 SH   DFND 1, 2 14,983,505 0 0
PAYPAL HLDGS INC COM 70450Y103 391,111 1,985,031 SH   DFND 1, 2 1,985,031 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 85,723 6,841,404 SH   DFND 1, 2 6,841,404 0 0
PEPSICO INC COM 713448108 365,147 2,635,320 SH   DFND 1, 2 2,635,320 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 20,359 2,859,438 SH   DFND 1, 2 2,859,438 0 0
PFIZER INC COM 717081103 205,687 5,604,540 SH   DFND 1, 2 5,604,540 0 0
PHILIP MORRIS INTL INC COM 718172109 4,525,136 60,346,649 SH   DFND 1, 2 60,342,805 0 3,844
PHREESIA INC COM 71944F106 30,384 945,659 SH   DFND 1, 2 945,659 0 0
PINTEREST INC CL A 72352L106 473,106 11,397,402 SH   DFND 1, 2 11,397,402 0 0
PIONEER NAT RES CO COM 723787107 542,693 6,311,049 SH   DFND 1, 2 6,296,658 0 14,391
PLUG POWER INC COM NEW 72919P202 11,299 842,573 SH   DFND 1, 2 842,573 0 0
POOL CORP COM 73278L105 23,050 68,900 SH   DFND 1, 2 68,900 0 0
PROCTER AND GAMBLE CO COM 742718109 569,689 4,099,625 SH   DFND 1, 2 4,099,625 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 252,664 4,601,412 SH   DFND 1, 2 4,601,412 0 0
PUBLIC STORAGE COM 74460D109 564,901 2,536,658 SH   DFND 1, 2 2,536,354 0 304
QUALCOMM INC COM 747525103 802,717 6,821,440 SH   DFND 1, 2 6,821,440 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 1,685,714 29,296,294 SH   DFND 1, 2 29,295,721 0 573
REALPAGE INC COM 75606N109 82,694 1,434,658 SH   DFND 1, 2 1,434,658 0 0
REGENERON PHARMACEUTICALS COM 75886F107 807,754 1,442,984 SH   DFND 1, 2 1,442,984 0 0
RELX PLC SPONSORED ADR 759530108 281,710 12,611,487 SH   DFND 1, 2 12,611,487 0 0
REVANCE THERAPEUTICS INC COM 761330109 29,210 1,161,900 SH   DFND 1, 2 1,161,900 0 0
RINGCENTRAL INC CL A 76680R206 682,053 2,483,716 SH   DFND 1, 2 2,483,716 0 0
RIO TINTO PLC SPONSORED ADR 767204100 6,164 102,372 SH   DFND 1, 2 102,372 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 69,876 2,884,419 SH   DFND 1, 2 2,850,470 0 33,949
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 784 31,165 SH   DFND 1, 2 31,165 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 2,086 416,396 SH   DFND 1, 2 416,396 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 676,731 8,278,286 SH   DFND 1, 2 8,271,738 0 6,548
S&P GLOBAL INC COM 78409V104 1,432,066 3,971,349 SH   DFND 1, 2 3,971,044 0 305
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,838 8,538 SH   DFND 1, 2 6,827 0 1,711
SVB FINANCIAL GROUP COM 78486Q101 464,209 1,929,220 SH   DFND 1, 2 1,929,220 0 0
SVMK INC COM 78489X103 152,982 6,919,121 SH   DFND 1, 2 6,919,121 0 0
SABRE CORP COM 78573M104 2,418 371,400 SH   DFND 1, 2 371,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,218 69,010 SH   DFND 1, 2 69,010 0 0
SAIA INC COM 78709Y105 47,328 375,200 SH   DFND 1, 2 375,200 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 11,489 1,361,300 SH   DFND 1, 2 1,361,300 0 0
SAP SE SPON ADR 803054204 261,300 1,672,725 SH   DFND 1, 2 1,672,725 0 0
SAREPTA THERAPEUTICS INC COM 803607100 21,292 151,623 SH   DFND 1, 2 151,623 0 0
SCHLUMBERGER LTD COM 806857108 457,360 29,393,214 SH   DFND 1, 2 29,361,409 0 31,805
SCHRODINGER INC COM 80810D103 14,752 310,500 SH   DFND 1, 2 310,500 0 0
SEA LTD SPONSORD ADS 81141R100 111,203 721,911 SH   DFND 1, 2 721,911 0 0
SEATTLE GENETICS INC COM 812578102 3,645,865 18,636,304 SH   DFND 1, 2 18,630,935 0 5,369
SEMPRA ENERGY COM 816851109 2,061,344 17,418,122 SH   DFND 1, 2 17,401,189 0 16,933
SEMPRA ENERGY 6% PFD CONV A 816851406 279,215 2,836,112 SH   DFND 1, 2 2,836,112 0 0
SERVICENOW INC COM 81762P102 1,599,081 3,297,067 SH   DFND 1, 2 3,295,977 0 1,090
SHAW COMMUNICATIONS INC CL B CONV 82028K200 300 16,452 SH   DFND 1, 2 16,452 0 0
SHERWIN WILLIAMS CO COM 824348106 479,635 688,246 SH   DFND 1, 2 688,246 0 0
SHOPIFY INC CL A 82509L107 133,385 130,390 SH   DFND 1, 2 130,390 0 0
SILK RD MED INC COM 82710M100 21,548 320,600 SH   DFND 1, 2 320,600 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 49,325 2,429,784 SH   DFND 1, 2 2,429,784 0 0
SLACK TECHNOLOGIES INC COM CL A 83088V102 62,125 2,312,930 SH   DFND 1, 2 2,312,930 0 0
SMARTSHEET INC COM CL A 83200N103 164,219 3,322,917 SH   DFND 1, 2 3,321,911 0 1,006
SNOWFLAKE INC CL A 833445109 74,549 297,006 SH   DFND 1, 2 297,006 0 0
SOUTH ST CORP COM 840441109 31,724 658,866 SH   DFND 1, 2 658,866 0 0
SQUARE INC CL A 852234103 134,479 827,308 SH   DFND 1, 2 827,308 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 36,846 651,450 SH   DFND 1, 2 651,450 0 0
STATE STR CORP COM 857477103 1,091,635 18,398,431 SH   DFND 1, 2 18,398,431 0 0
STMICROELECTRONICS N V NY REGISTRY 861012102 12,208 398,941 SH   DFND 1, 2 397,041 0 1,900
SUN LIFE FINANCIAL INC. COM 866796105 314 7,700 SH   DFND 1, 2 7,700 0 0
SUNCOR ENERGY INC NEW COM 867224107 220,896 18,089,592 SH   DFND 1, 2 18,089,592 0 0
SYNNEX CORP COM 87162W100 176,424 1,259,631 SH   DFND 1, 2 1,259,631 0 0
SYSCO CORP COM 871829107 221,087 3,553,309 SH   DFND 1, 2 3,553,309 0 0
TFI INTL INC COM 87241L109 89,618 2,142,856 SH   DFND 1, 2 2,142,856 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2,954,142 36,458,124 SH   DFND 1, 2 36,435,534 0 22,590
TC ENERGY CORP COM 87807B107 1,208,258 28,761,634 SH   DFND 1, 2 28,761,159 0 475
TELADOC HEALTH INC COM 87918A105 33,724 153,822 SH   DFND 1, 2 153,822 0 0
TELUS CORPORATION COM 87971M103 421 23,908 SH   DFND 1, 2 23,908 0 0
TERADATA CORP DEL COM 88076W103 28,347 1,248,757 SH   DFND 1, 2 1,248,757 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 210,952 23,413,709 SH   DFND 1, 2 23,380,978 0 32,731
TEXAS INSTRS INC COM 882508104 110,895 776,886 SH   DFND 1, 2 776,886 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 690,391 1,563,688 SH   DFND 1, 2 1,562,510 0 1,178
TOLL BROTHERS INC COM 889478103 19,862 408,184 SH   DFND 1, 2 408,184 0 0
TOPBUILD CORP COM 89055F103 25,091 147,000 SH   DFND 1, 2 147,000 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 55,717 1,204,931 SH   DFND 1, 2 1,204,931 0 0
TOTAL SE SPONSORED ADS 89151E109 22,949 688,540 SH   DFND 1, 2 688,540 0 0
TRADEWEB MKTS INC CL A 892672106 9,071 156,400 SH   DFND 1, 2 156,400 0 0
TRANSDIGM GROUP INC COM 893641100 2,716,527 5,717,098 SH   DFND 1, 2 5,715,968 0 1,130
TRAVELERS COMPANIES INC COM 89417E109 1,588,142 14,679,197 SH   DFND 1, 2 14,679,197 0 0
TRIMBLE INC COM 896239100 1,100,033 22,587,863 SH   DFND 1, 2 22,568,746 0 19,117
TRINITY INDS INC COM 896522109 185,155 9,495,041 SH   DFND 1, 2 9,495,041 0 0
TRIP COM GROUP LTD ADS 89677Q107 274,501 8,814,995 SH   DFND 1, 2 8,800,352 0 14,643
TRUIST FINL CORP COM 89832Q109 2,870,793 75,460,283 SH   DFND 1, 2 75,409,598 0 50,685
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 509,422 6,197,949 SH   DFND 1, 2 6,193,652 0 4,297
UNILEVER PLC SPON ADR NEW 904767704 162,460 2,632,480 SH   DFND 1, 2 2,632,480 0 0
UNION PAC CORP COM 907818108 1,454,021 7,385,664 SH   DFND 1, 2 7,371,395 0 14,269
UNITEDHEALTH GROUP INC COM 91324P102 5,628,274 18,055,831 SH   DFND 1, 2 18,047,271 0 8,560
UPWORK INC COM 91688F104 64,196 3,680,936 SH   DFND 1, 2 3,680,936 0 0
VAIL RESORTS INC COM 91879Q109 408,682 1,909,999 SH   DFND 1, 2 1,909,999 0 0
VALE S A SPONSORED ADS 91912E105 1,034,579 97,788,608 SH   DFND 1, 2 97,644,701 0 143,907
VANGUARD TAX-MANAGED INTL FD FTSE DEV MKT ETF 921943858 5,542 135,160 SH   DFND 1, 2 134,486 0 674
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 1,730 21,549 SH   DFND 1, 2 19,143 0 2,406
VENTAS INC COM 92276F100 109,753 2,615,666 SH   DFND 1, 2 2,615,666 0 0
VERISIGN INC COM 92343E102 798,098 3,896,013 SH   DFND 1, 2 3,896,013 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 2,349,887 39,500,681 SH   DFND 1, 2 39,467,739 0 32,942
VERTEX PHARMACEUTICALS INC COM 92532F100 1,492,833 5,486,084 SH   DFND 1, 2 5,483,941 0 2,143
VERTEX INC CL A 92538J106 34,883 1,516,646 SH   DFND 1, 2 1,516,646 0 0
VIACOMCBS INC CL B 92556H206 85,103 3,038,310 SH   DFND 1, 2 3,038,310 0 0
VICI PPTYS INC COM 925652109 349,495 14,954,401 SH   DFND 1, 2 14,954,401 0 0
VIOMI TECHNOLOGY CO LTD SPONSORED ADS 92762J103 2,269 375,000 SH   DFND 1, 2 375,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 387,349 11,283,094 SH   DFND 1, 2 11,283,094 0 0
VISA INC COM CL A 92826C839 4,118,928 20,598,497 SH   DFND 1, 2 20,577,003 0 21,494
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 4,740 354,404 SH   DFND 1, 2 354,404 0 0
WABTEC COM 929740108 628,693 10,159,135 SH   DFND 1, 2 10,159,135 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 51,791 1,441,847 SH   DFND 1, 2 1,441,847 0 0
WASTE CONNECTIONS INC COM 94106B101 1,038,502 10,003,875 SH   DFND 1, 2 10,003,875 0 0
WASTE MGMT INC DEL COM 94106L109 238,194 2,104,644 SH   DFND 1, 2 2,104,644 0 0
WEBSTER FINL CORP CONN COM 947890109 22,491 851,600 SH   DFND 1, 2 851,600 0 0
WELLS FARGO CO NEW COM 949746101 167,030 7,104,619 SH   DFND 1, 2 7,104,619 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 219,493 4,473,696 SH   DFND 1, 2 4,473,696 0 0
WYNDHAM HOTELS & RESORTS INC COM 98311A105 9,499 188,100 SH   DFND 1, 2 188,100 0 0
WYNN RESORTS LTD COM 983134107 312,112 4,346,352 SH   DFND 1, 2 4,346,348 0 4
XCEL ENERGY INC COM 98389B100 897,355 13,003,300 SH   DFND 1, 2 12,996,054 0 7,246
XENON PHARMACEUTICALS INC COM 98420N105 11,687 1,055,726 SH   DFND 1, 2 1,055,726 0 0
YEXT INC COM 98585N106 22,078 1,454,400 SH   DFND 1, 2 1,454,400 0 0
YETI HLDGS INC COM 98585X104 35,381 780,700 SH   DFND 1, 2 780,700 0 0
YUM BRANDS INC COM 988498101 208,536 2,284,535 SH   DFND 1, 2 2,284,535 0 0
YUM CHINA HLDGS INC COM 98850P109 138,832 2,622,335 SH   DFND 1, 2 2,607,620 0 14,715
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 9,164 36,300 SH   DFND 1, 2 36,300 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 210,321 1,544,891 SH   DFND 1, 2 1,544,891 0 0
ZOETIS INC CL A 98978V103 546,485 3,304,633 SH   DFND 1, 2 3,304,162 0 471
AON PLC SHS CL A G0403H108 2,067,103 10,021,389 SH   DFND 1, 2 10,017,918 0 3,471
ARCH CAP GROUP LTD ORD G0450A105 319,174 10,911,916 SH   DFND 1, 2 10,911,916 0 0
AXALTA COATING SYS LTD COM G0750C108 31,029 1,399,600 SH   DFND 1, 2 1,399,600 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 373,624 5,747,185 SH   DFND 1, 2 5,747,185 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 94,512 418,213 SH   DFND 1, 2 418,213 0 0
BROOKFIELD PROPERTY PARTRS L UNIT LTD PARTN G16249107 34,291 2,850,460 SH   DFND 1, 2 2,850,460 0 0
CREDICORP LTD COM G2519Y108 22,743 183,425 SH   DFND 1, 2 183,425 0 0
COSAN LTD SHS A G25343107 5,361 361,000 SH   DFND 1, 2 361,000 0 0
DESPEGAR COM CORP ORD SHS G27358103 3,699 581,609 SH   DFND 1, 2 581,609 0 0
EVEREST RE GROUP LTD COM G3223R108 405,395 2,052,026 SH   DFND 1, 2 2,052,026 0 0
FABRINET SHS G3323L100 20,516 325,500 SH   DFND 1, 2 325,500 0 0
FRESH DEL MONTE PRODUCE INC ORD G36738105 7,603 331,700 SH   DFND 1, 2 331,700 0 0
HELEN OF TROY LTD COM G4388N106 8,708 45,000 SH   DFND 1, 2 45,000 0 0
JOHNSON CTLS INTL PLC SHS G51502105 796,551 19,499,291 SH   DFND 1, 2 19,452,174 0 47,117
LINDE PLC SHS G5494J103 859,131 3,608,026 SH   DFND 1, 2 3,608,026 0 0
NEW FRONTIER HEALTH CORP ORD SHS G6461G106 16,720 2,191,400 SH   DFND 1, 2 2,191,400 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 12,144 856,400 SH   DFND 1, 2 856,400 0 0
NOVOCURE LTD ORD SHS G6674U108 912,583 8,198,569 SH   DFND 1, 2 8,198,569 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 109,805 2,911,836 SH   DFND 1, 2 2,911,836 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 195,799 1,153,547 SH   DFND 1, 2 1,153,547 0 0
ROYALTY PHARMA PLC SHS CL A G7709Q104 436,436 10,374,043 SH   DFND 1, 2 10,374,043 0 0
CHUBB LIMITED COM H1467J104 2,600,818 22,399,622 SH   DFND 1, 2 22,386,917 0 12,705
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 618,464 7,394,274 SH   DFND 1, 2 7,389,124 0 5,150
UBS GROUP AG SHS H42097107 427,836 38,320,944 SH   DFND 1, 2 38,320,944 0 0
GLOBANT S A COM L44385109 71,066 396,531 SH   DFND 1, 2 396,531 0 0
NEXA RES S A COM L67359106 33,095 6,256,144 SH   DFND 1, 2 6,256,144 0 0
JFROG LTD ORD SHS M6191J100 16,930 200,000 SH   DFND 1, 2 200,000 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 2,496,464 6,755,249 SH   DFND 1, 2 6,747,649 0 7,600
ELASTIC N V ORD SHS N14506104 250,080 2,317,919 SH   DFND 1, 2 2,317,919 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 2,219,250 31,483,343 SH   DFND 1, 2 31,468,819 0 14,524
YANDEX N V SHS CLASS A N97284108 642,791 9,851,366 SH   DFND 1, 2 9,833,869 0 17,497
ROYAL CARIBBEAN GROUP COM V7780T103 272,867 4,215,958 SH   DFND 1, 2 4,215,958 0 0
FLEX LTD ORD Y2573F102 256,366 23,013,122 SH   DFND 1, 2 23,013,122 0 0