The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AGNC INVT CORP COM 00123Q104 151,750 10,909,409 SH   DFND 1, 2 10,909,409 0 0
AES CORP COM 00130H105 1,471,348 81,245,083 SH   DFND 1, 2 81,245,083 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 11,322 300,000 SH   DFND 1, 2 300,000 0 0
ABBOTT LABS COM 002824100 300,538 2,761,775 SH   DFND 1, 2 2,754,573 0 7,202
ACACIA COMMUNICATIONS INC COM 00401C108 25,612 380,000 SH   DFND 1, 2 380,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,607,547 32,211,831 SH   DFND 1, 2 32,208,370 0 3,461
ACUTUS MED INC COM 005111109 30,871 1,035,935 SH   DFND 1, 2 1,035,935 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 63,862 8,002,700 SH   DFND 1, 2 8,002,700 0 0
ADDUS HOMECARE CORP COM 006739106 58,738 621,500 SH   DFND 1, 2 621,500 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,252,213 2,553,300 SH   DFND 1, 2 2,551,184 0 2,116
AEROJET ROCKETDYNE HLDGS INC COM 007800105 18,008 451,433 SH   DFND 1, 2 451,433 0 0
ADVANCED MICRO DEVICES INC COM 007903107 3,796,079 46,299,316 SH   DFND 1, 2 46,292,123 0 7,193
AGORA INC ADS 00851L103 63,610 1,480,000 SH   DFND 1, 2 1,480,000 0 0
AIR PRODS & CHEMS INC COM 009158106 1,100,019 3,693,073 SH   DFND 1, 2 3,693,073 0 0
ALARM COM HLDGS INC COM 011642105 84,367 1,527,000 SH   DFND 1, 2 1,527,000 0 0
ALCOA CORP COM 013872106 10,583 910,000 SH   DFND 1, 2 910,000 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 547,012 3,418,826 SH   DFND 1, 2 3,418,826 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 302 20,789 SH   DFND 1, 2 20,789 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2,375 8,574 SH   DFND 1, 2 6 0 8,568
ALLAKOS INC COM 01671P100 471,975 5,794,660 SH   DFND 1, 2 5,794,660 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 23,879 2,738,427 SH   DFND 1, 2 2,738,427 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 100,523 2,665,686 SH   DFND 1, 2 2,665,686 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 51,331 352,546 SH   DFND 1, 2 352,546 0 0
ALPHABET INC CAP STK CL C 02079K107 3,394,391 2,309,738 SH   DFND 1, 2 2,308,655 0 1,083
ALPHABET INC CAP STK CL A 02079K305 2,580,495 1,760,708 SH   DFND 1, 2 1,757,172 0 3,536
ALTIMMUNE INC COM NEW 02155H200 11,365 861,000 SH   DFND 1, 2 861,000 0 0
ALTERYX INC COM CL A 02156B103 522,507 4,601,556 SH   DFND 1, 2 4,599,421 0 2,135
ALTICE USA INC CL A 02156K103 84,031 3,231,972 SH   DFND 1, 2 3,231,972 0 0
ALTRIA GROUP INC COM 02209S103 4,079,101 105,566,793 SH   DFND 1, 2 105,566,793 0 0
AMAZON COM INC COM 023135106 10,903,615 3,462,864 SH   DFND 1, 2 3,460,704 0 2,160
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 229,148 18,346,691 SH   DFND 1, 2 18,337,075 0 9,616
AMERICAN AIRLS GROUP INC NOTE 6.500% 7/0 02376RAF9 3,136 3,383,000 PRN   DFND 1, 2 3,383,000 0 0
AMERICAN ELEC PWR CO INC COM 025537101 1,154,987 14,131,743 SH   DFND 1, 2 14,131,743 0 0
AMERICAN ELEC PWR CO INC UNIT 03/15/2022 025537127 118,166 2,435,904 SH   DFND 1, 2 2,435,904 0 0
AMERICAN ELEC PWR CO INC UNIT 99/99/9999 02557T307 75,491 1,540,000 SH   DFND 1, 2 1,540,000 0 0
AMERICAN TOWER CORP NEW COM 03027X100 2,238,105 9,258,705 SH   DFND 1, 2 9,257,670 0 1,035
AMERICAN WELL CORP CL A 03044L105 51,870 1,750,000 SH   DFND 1, 2 1,750,000 0 0
AMPHENOL CORP NEW CL A 032095101 50,022 462,010 SH   DFND 1, 2 462,010 0 0
ANALOG DEVICES INC COM 032654105 588,666 5,042,542 SH   DFND 1, 2 5,042,540 0 2
APACHE CORP COM 037411105 23,471 2,478,500 SH   DFND 1, 2 2,478,500 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 503,244 11,245,683 SH   DFND 1, 2 11,245,683 0 0
APPLE INC COM 037833100 2,774,976 23,961,724 SH   DFND 1, 2 23,943,445 0 18,279
APPLIED MATLS INC COM 038222105 1,285,081 21,616,165 SH   DFND 1, 2 21,616,165 0 0
APPLIED MOLECULAR TRANS INC COM 03824M109 44,322 1,392,897 SH   DFND 1, 2 1,392,897 0 0
ARAMARK COM 03852U106 144,775 5,473,543 SH   DFND 1, 2 5,473,543 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 817,867 17,592,312 SH   DFND 1, 2 17,592,312 0 0
ARCOSA INC COM 039653100 27,969 634,359 SH   DFND 1, 2 634,359 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 412,893 10,215,079 SH   DFND 1, 2 10,215,079 0 0
ARGENX SE SPONSORED ADR 04016X101 173,693 661,639 SH   DFND 1, 2 661,639 0 0
ARISTA NETWORKS INC COM 040413106 497,107 2,402,295 SH   DFND 1, 2 2,402,295 0 0
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 27,488 705,000 SH   DFND 1, 2 705,000 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 48,915 2,250,000 SH   DFND 1, 2 2,250,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 302,382 5,517,579 SH   DFND 1, 2 5,456,789 0 60,790
AUTODESK INC COM 052769106 1,842,096 7,974,079 SH   DFND 1, 2 7,971,828 0 2,251
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 34,406 2,955,806 SH   DFND 1, 2 2,955,806 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 22,931 164,393 SH   DFND 1, 2 164,393 0 0
BCE INC COM NEW 05534B760 311 7,500 SH   DFND 1, 2 7,500 0 0
BP PLC SPONSORED ADR 055622104 35,199 2,015,981 SH   DFND 1, 2 2,015,981 0 0
BMC STK HLDGS INC COM 05591B109 24,808 579,222 SH   DFND 1, 2 579,222 0 0
BAKER HUGHES COMPANY CL A 05722G100 860,463 64,745,167 SH   DFND 1, 2 64,745,167 0 0
BANDWIDTH INC COM CL A 05988J103 131,451 753,000 SH   DFND 1, 2 753,000 0 0
BK OF AMERICA CORP COM 060505104 1,774,332 73,654,278 SH   DFND 1, 2 73,654,278 0 0
BANK NOVA SCOTIA B C COM 064149107 587,988 14,157,884 SH   DFND 1, 2 14,157,884 0 0
BARRICK GOLD CORP COM 067901108 1,212,048 43,126,869 SH   DFND 1, 2 43,126,869 0 0
BARRETT BUSINESS SVCS INC COM 068463108 21,658 413,000 SH   DFND 1, 2 413,000 0 0
BAUSCH HEALTH COS INC COM 071734107 14,777 950,922 SH   DFND 1, 2 950,922 0 0
BAXTER INTL INC COM 071813109 421,855 5,245,643 SH   DFND 1, 2 5,245,643 0 0
BEAZER HOMES USA INC COM NEW 07556Q881 21,910 1,659,813 SH   DFND 1, 2 1,659,813 0 0
BELLRING BRANDS INC COM CL A 079823100 20,740 1,000,000 SH   DFND 1, 2 1,000,000 0 0
BENTLEY SYS INC COM CL B 08265T208 18,840 600,000 SH   DFND 1, 2 600,000 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 212,801 665 SH   DFND 1, 2 665 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 1,784,300 8,379,358 SH   DFND 1, 2 8,379,358 0 0
BEYOND MEAT INC COM 08862E109 15,177 91,395 SH   DFND 1, 2 91,395 0 0
BIOGEN INC COM 09062X103 90,203 317,974 SH   DFND 1, 2 317,974 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 15,871 525,000 SH   DFND 1, 2 525,000 0 0
BLACK KNIGHT INC COM 09215C105 10,272 118,000 SH   DFND 1, 2 118,000 0 0
BLACKLINE INC COM 09239B109 53,330 595,000 SH   DFND 1, 2 595,000 0 0
BLACKROCK INC COM 09247X101 3,910,836 6,939,733 SH   DFND 1, 2 6,933,980 0 5,753
BLACKSTONE GROUP INC COM CL A 09260D107 999,539 19,148,253 SH   DFND 1, 2 19,148,253 0 0
BLUEBIRD BIO INC COM 09609G100 187,290 3,471,543 SH   DFND 1, 2 3,471,543 0 0
BOEING CO COM 097023105 1,225,653 7,416,515 SH   DFND 1, 2 7,416,476 0 39
BOOKING HOLDINGS INC COM 09857L108 558,819 326,665 SH   DFND 1, 2 326,665 0 0
BOOT BARN HLDGS INC COM 099406100 37,004 1,315,000 SH   DFND 1, 2 1,315,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 2,336,011 61,136,588 SH   DFND 1, 2 61,097,598 0 38,990
BOSTON SCIENTIFIC CORP 5.50% CNV PFD A 101137206 166,808 1,491,091 SH   DFND 1, 2 1,491,091 0 0
BOTTOMLINE TECH DEL INC COM 101388106 192,957 4,576,781 SH   DFND 1, 2 4,576,781 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100 488,465 3,212,740 SH   DFND 1, 2 3,212,740 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 660,788 10,960,151 SH   DFND 1, 2 10,960,151 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 157,808 4,365,871 SH   DFND 1, 2 4,329,420 0 36,451
BROADCOM INC COM 11135F101 14,312,268 39,284,885 SH   DFND 1, 2 39,262,265 0 22,620
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 412,732 12,483,494 SH   DFND 1, 2 12,443,765 0 39,729
BROOKFIELD INFRASTRUCTURE CO COM SB VTG SHS A 11275Q107 7,903 142,590 SH   DFND 1, 2 142,590 0 0
BURLINGTON STORES INC COM 122017106 555,223 2,694,080 SH   DFND 1, 2 2,694,080 0 0
CDW CORP COM 12514G108 77,695 650,000 SH   DFND 1, 2 650,000 0 0
CF INDS HLDGS INC COM 125269100 178,769 5,821,212 SH   DFND 1, 2 5,821,212 0 0
CIGNA CORP NEW COM 125523100 2,464,558 14,548,192 SH   DFND 1, 2 14,538,061 0 10,131
CIT GROUP INC COM NEW 125581801 86,428 4,880,200 SH   DFND 1, 2 4,880,200 0 0
CME GROUP INC COM 12572Q105 5,811,306 34,733,807 SH   DFND 1, 2 34,727,373 0 6,434
CMS ENERGY CORP COM 125896100 436,243 7,104,015 SH   DFND 1, 2 7,057,013 0 47,002
CSX CORP COM 126408103 5,282,080 68,006,717 SH   DFND 1, 2 67,977,621 0 29,096
CVS HEALTH CORP COM 126650100 1,933,946 33,115,846 SH   DFND 1, 2 33,092,867 0 22,979
CABOT OIL & GAS CORP COM 127097103 207,300 11,941,218 SH   DFND 1, 2 11,941,218 0 0
CABOT MICROELECTRONICS CORP COM 12709P103 54,011 378,200 SH   DFND 1, 2 378,200 0 0
CAESARS ENTERTAINMENT INC NE COM 12769G100 632,424 11,281,200 SH   DFND 1, 2 11,281,200 0 0
CAMDEN PPTY TR SH BEN INT 133131102 229,594 2,580,285 SH   DFND 1, 2 2,580,285 0 0
CANADIAN NAT RES LTD COM 136385101 521,223 32,522,666 SH   DFND 1, 2 32,515,853 0 6,813
CANNAE HLDGS INC COM 13765N107 201,399 5,405,240 SH   DFND 1, 2 5,405,240 0 0
CAPITAL ONE FINL CORP COM 14040H105 1,554,343 21,630,866 SH   DFND 1, 2 21,594,568 0 36,298
CARGURUS INC COM CL A 141788109 17,520 810,000 SH   DFND 1, 2 810,000 0 0
CARLYLE GROUP INC COM 14316J108 311,264 12,617,110 SH   DFND 1, 2 12,617,110 0 0
CARVANA CO CL A 146869102 99,004 443,843 SH   DFND 1, 2 443,843 0 0
CATERPILLAR INC DEL COM 149123101 226,570 1,519,243 SH   DFND 1, 2 1,504,913 0 14,330
CAVCO INDS INC DEL COM 149568107 30,810 170,870 SH   DFND 1, 2 170,870 0 0
CELLECTIS S A SPON ADS 15117K103 16,188 875,000 SH   DFND 1, 2 875,000 0 0
CENTENE CORP DEL COM 15135B101 2,259,758 38,740,917 SH   DFND 1, 2 38,740,917 0 0
CENOVUS ENERGY INC COM 15135U109 49,885 12,798,618 SH   DFND 1, 2 12,798,618 0 0
CENTURY CMNTYS INC COM 156504300 38,563 911,000 SH   DFND 1, 2 911,000 0 0
CERIDIAN HCM HLDG INC COM 15677J108 693,731 8,393,605 SH   DFND 1, 2 8,393,605 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 1,347,863 2,158,860 SH   DFND 1, 2 2,158,860 0 0
CHEMED CORP NEW COM 16359R103 134,117 279,207 SH   DFND 1, 2 279,207 0 0
CHEVRON CORP NEW COM 166764100 1,026,640 14,258,913 SH   DFND 1, 2 14,246,017 0 12,896
CHEWY INC CL A 16679L109 8,861 161,600 SH   DFND 1, 2 161,600 0 0
CHINDATA GROUP HLDGS LTD ADS 16955F107 116,797 7,196,382 SH   DFND 1, 2 7,196,382 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 387,207 311,332 SH   DFND 1, 2 311,332 0 0
CIMAREX ENERGY CO COM 171798101 21,532 885,000 SH   DFND 1, 2 885,000 0 0
CINTAS CORP COM 172908105 195,192 586,462 SH   DFND 1, 2 586,462 0 0
CITIGROUP INC COM NEW 172967424 907,038 21,040,073 SH   DFND 1, 2 21,040,073 0 0
CLEAR CHANNEL OUTDOOR HLDGS COM 18453H106 1,044 1,043,695 SH   DFND 1, 2 1,043,695 0 0
CLOUDFLARE INC CL A COM 18915M107 29,774 725,122 SH   DFND 1, 2 725,122 0 0
COCA COLA CO COM 191216100 1,023,389 20,729,187 SH   DFND 1, 2 20,703,727 0 25,460
COLGATE PALMOLIVE CO COM 194162103 1,906,990 24,717,948 SH   DFND 1, 2 24,717,948 0 0
COMCAST CORP NEW CL A 20030N101 4,610,347 99,661,738 SH   DFND 1, 2 99,575,800 0 85,938
CONAGRA BRANDS INC COM 205887102 2,040,623 57,144,527 SH   DFND 1, 2 57,107,971 0 36,556
CONCHO RES INC COM 20605P101 48,334 1,095,514 SH   DFND 1, 2 1,095,514 0 0
CONOCOPHILLIPS COM 20825C104 304,777 9,280,660 SH   DFND 1, 2 9,280,654 0 6
CONSTELLATION BRANDS INC CL A 21036P108 543,301 2,866,870 SH   DFND 1, 2 2,866,870 0 0
COOPER TIRE & RUBR CO COM 216831107 19,527 616,000 SH   DFND 1, 2 616,000 0 0
COPART INC COM 217204106 519,633 4,941,355 SH   DFND 1, 2 4,941,355 0 0
CORTEVA INC COM 22052L104 265,587 9,218,553 SH   DFND 1, 2 9,218,553 0 0
CORTEXYME INC COM 22053A107 130,267 2,605,334 SH   DFND 1, 2 2,605,334 0 0
COSTCO WHSL CORP NEW COM 22160K105 1,849,767 5,210,658 SH   DFND 1, 2 5,204,831 0 5,827
COSTAR GROUP INC COM 22160N109 42,426 50,000 SH   DFND 1, 2 50,000 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 3,642,892 21,879,232 SH   DFND 1, 2 21,879,232 0 0
CUMULUS MEDIA INC COM CL A 231082801 4,184 779,084 SH   DFND 1, 2 779,084 0 0
D R HORTON INC COM 23331A109 488,025 6,452,798 SH   DFND 1, 2 6,452,798 0 0
DTE ENERGY CO COM 233331107 2,540,382 22,082,595 SH   DFND 1, 2 22,082,595 0 0
DTE ENERGY CO UNIT 11/01/2022S 233331842 164,966 3,652,915 SH   DFND 1, 2 3,652,915 0 0
DANAHER CORPORATION COM 235851102 660,121 3,065,626 SH   DFND 1, 2 3,065,626 0 0
DANAHER CORPORATION 4.75 MND CV PFD 235851300 221,378 150,000 SH   DFND 1, 2 150,000 0 0
DARDEN RESTAURANTS INC COM 237194105 1,070,374 10,625,119 SH   DFND 1, 2 10,625,119 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 13,851 270,000 SH   DFND 1, 2 270,000 0 0
DEERE & CO COM 244199105 534,832 2,413,177 SH   DFND 1, 2 2,413,177 0 0
DELL TECHNOLOGIES INC CL C 24703L202 696,317 10,286,852 SH   DFND 1, 2 10,286,852 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 646,499 21,141,240 SH   DFND 1, 2 21,141,240 0 0
DENBURY INC COM 24790A101 45,079 2,561,307 SH   DFND 1, 2 2,561,307 0 0
DEXCOM INC COM 252131107 724,769 1,758,166 SH   DFND 1, 2 1,758,166 0 0
DIAMONDBACK ENERGY INC COM 25278X109 98,878 3,282,802 SH   DFND 1, 2 3,282,802 0 0
DIEBOLD NXDF INC COM 253651103 7,923 1,037,000 SH   DFND 1, 2 1,037,000 0 0
DIGITAL RLTY TR INC COM 253868103 3,668,502 24,996,534 SH   DFND 1, 2 24,982,178 0 14,356
DISNEY WALT CO COM DISNEY 254687106 405,887 3,271,171 SH   DFND 1, 2 3,271,171 0 0
DISCOVER FINL SVCS COM 254709108 386,086 6,682,937 SH   DFND 1, 2 6,657,531 0 25,406
DISH NETWORK CORPORATION NOTE 3.375% 8/1 25470MAB5 35,743 38,830,000 PRN   DFND 1, 2 38,830,000 0 0
DOCUSIGN INC COM 256163106 518,448 2,408,698 SH   DFND 1, 2 2,408,698 0 0
DOLLAR GEN CORP NEW COM 256677105 2,274,644 10,851,274 SH   DFND 1, 2 10,851,274 0 0
DOMINION ENERGY INC COM 25746U109 158,371 2,006,478 SH   DFND 1, 2 2,006,478 0 0
DOMINION ENERGY INC UNIT 99/99/9999 25746U133 230,459 2,264,728 SH   DFND 1, 2 2,264,728 0 0
DOMINOS PIZZA INC COM 25754A201 1,425,234 3,351,285 SH   DFND 1, 2 3,351,285 0 0
DOW INC COM 260557103 2,428,721 51,620,148 SH   DFND 1, 2 51,605,183 0 14,965
DRAFTKINGS INC COM CL A 26142R104 106,324 1,807,000 SH   DFND 1, 2 1,807,000 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 310,846 3,510,000 SH   DFND 1, 2 3,510,000 0 0
DUN & BRADSTREET HLDGS INC COM 26484T106 368,432 14,358,210 SH   DFND 1, 2 14,358,210 0 0
DUPONT DE NEMOURS INC COM 26614N102 204,164 3,679,963 SH   DFND 1, 2 3,679,963 0 0
EOG RES INC COM 26875P101 154,431 4,296,910 SH   DFND 1, 2 4,296,910 0 0
EASTMAN CHEM CO COM 277432100 557,215 7,132,814 SH   DFND 1, 2 7,132,814 0 0
EDITAS MEDICINE INC COM 28106W103 49,386 1,760,000 SH   DFND 1, 2 1,760,000 0 0
EHEALTH INC COM 28238P109 16,084 203,600 SH   DFND 1, 2 203,600 0 0
EMERSON ELEC CO COM 291011104 742,261 11,320,129 SH   DFND 1, 2 11,320,129 0 0
ENBRIDGE INC COM 29250N105 276,724 9,476,441 SH   DFND 1, 2 9,469,411 0 7,030
ENDAVA PLC ADS 29260V105 73,620 1,165,798 SH   DFND 1, 2 1,165,798 0 0
EPAM SYS INC COM 29414B104 829,834 2,566,920 SH   DFND 1, 2 2,566,920 0 0
EQUIFAX INC COM 294429105 23,766 151,472 SH   DFND 1, 2 151,472 0 0
EQUINIX INC COM 29444U700 1,894,244 2,492,000 SH   DFND 1, 2 2,492,000 0 0
ESSENTIAL UTILS INC UNIT 04/30/2022 29670G201 2,226 41,600 SH   DFND 1, 2 41,600 0 0
ETSY INC COM 29786A106 50,586 415,900 SH   DFND 1, 2 415,900 0 0
EXACT SCIENCES CORP COM 30063P105 747,345 7,330,510 SH   DFND 1, 2 7,330,510 0 0
EXTRA SPACE STORAGE INC COM 30225T102 344,367 3,218,683 SH   DFND 1, 2 3,218,683 0 0
EXXON MOBIL CORP COM 30231G102 325,481 9,480,999 SH   DFND 1, 2 9,451,590 0 29,409
FLIR SYS INC COM 302445101 97,603 2,722,526 SH   DFND 1, 2 2,722,526 0 0
FACEBOOK INC CL A 30303M102 10,708,373 40,887,265 SH   DFND 1, 2 40,874,169 0 13,096
FIDELITY NATL INFORMATION SV COM 31620M106 75,112 510,237 SH   DFND 1, 2 510,237 0 0
FIFTH THIRD BANCORP COM 316773100 11,925 559,335 SH   DFND 1, 2 559,335 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 551,077 5,052,972 SH   DFND 1, 2 5,052,972 0 0
FIRSTSERVICE CORP NEW COM 33767E202 26,393 200,000 SH   DFND 1, 2 200,000 0 0
FISERV INC COM 337738108 584,150 5,668,609 SH   DFND 1, 2 5,668,609 0 0
FIVE BELOW INC COM 33829M101 465,511 3,665,443 SH   DFND 1, 2 3,665,443 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 677,923 2,847,219 SH   DFND 1, 2 2,847,219 0 0
FLEXION THERAPEUTICS INC COM 33938J106 39,797 3,823,000 SH   DFND 1, 2 3,823,000 0 0
FLOOR & DECOR HLDGS INC CL A 339750101 809,502 10,822,219 SH   DFND 1, 2 10,822,219 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 78,552 2,395,600 SH   DFND 1, 2 2,395,600 0 0
FRANCO NEV CORP COM 351858105 929,614 6,652,484 SH   DFND 1, 2 6,652,484 0 0
FRONTDOOR INC COM 35905A109 22,101 568,000 SH   DFND 1, 2 568,000 0 0
FULLER H B CO COM 359694106 19,685 430,000 SH   DFND 1, 2 430,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 268,165 2,754,644 SH   DFND 1, 2 2,754,644 0 0
GALAPAGOS NV SPON ADR 36315X101 546 3,854 SH   DFND 1, 2 2 0 3,852
GAMING & LEISURE PPTYS INC COM 36467J108 651,010 17,628,229 SH   DFND 1, 2 17,628,200 0 29
GENERAL ELECTRIC CO COM 369604103 35,522 5,701,725 SH   DFND 1, 2 5,701,725 0 0
GENERAL MLS INC COM 370334104 1,038,541 16,837,566 SH   DFND 1, 2 16,837,566 0 0
GENERAL MTRS CO COM 37045V100 2,697,422 91,162,021 SH   DFND 1, 2 91,089,144 0 72,877
GENETRON HLDGS LTD ADS 37186H100 29,518 2,472,191 SH   DFND 1, 2 2,472,191 0 0
GENTEX CORP COM 371901109 86,884 3,374,134 SH   DFND 1, 2 3,374,134 0 0
GILEAD SCIENCES INC COM 375558103 2,486,027 39,342,449 SH   DFND 1, 2 39,321,656 0 20,793
GLAUKOS CORP COM 377322102 56,964 1,150,322 SH   DFND 1, 2 1,150,322 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 15,076 400,520 SH   DFND 1, 2 400,520 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 80,142 1,453,421 SH   DFND 1, 2 1,453,421 0 0
GODADDY INC CL A 380237107 10,788 142,000 SH   DFND 1, 2 142,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 162,875 810,488 SH   DFND 1, 2 808,337 0 2,151
GOODRX HLDGS INC COM CL A 38246G108 72,291 1,300,203 SH   DFND 1, 2 1,300,203 0 0
GOSSAMER BIO INC COM 38341P102 3,872 312,000 SH   DFND 1, 2 312,000 0 0
GRACO INC COM 384109104 58,528 954,000 SH   DFND 1, 2 954,000 0 0
GRAND CANYON ED INC COM 38526M106 300,202 3,755,340 SH   DFND 1, 2 3,755,340 0 0
GREENHILL & CO INC COM 395259104 13,276 1,169,700 SH   DFND 1, 2 1,169,700 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 185,213 10,675,124 SH   DFND 1, 2 10,675,124 0 0
GROCERY OUTLET HLDG CORP COM 39874R101 31,535 802,000 SH   DFND 1, 2 802,000 0 0
GUIDEWIRE SOFTWARE INC COM 40171V100 375,742 3,603,551 SH   DFND 1, 2 3,603,551 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 38,713 776,193 SH   DFND 1, 2 710,713 0 65,480
HAEMONETICS CORP COM 405024100 72,932 835,900 SH   DFND 1, 2 835,900 0 0
HALLIBURTON CO COM 406216101 715,696 59,393,897 SH   DFND 1, 2 59,393,897 0 0
HARLEY DAVIDSON INC COM 412822108 14,528 592,000 SH   DFND 1, 2 592,000 0 0
HEICO CORP NEW COM 422806109 194,914 1,862,357 SH   DFND 1, 2 1,862,357 0 0
HELMERICH & PAYNE INC COM 423452101 19,924 1,360,000 SH   DFND 1, 2 1,360,000 0 0
HENRY JACK & ASSOC INC COM 426281101 466,772 2,870,852 SH   DFND 1, 2 2,870,852 0 0
HESS CORP COM 42809H107 102,466 2,503,441 SH   DFND 1, 2 2,503,441 0 0
HOME DEPOT INC COM 437076102 9,002,859 32,418,614 SH   DFND 1, 2 32,398,227 0 20,387
HONEYWELL INTL INC COM 438516106 4,689,380 28,487,835 SH   DFND 1, 2 28,465,132 0 22,703
HUBBELL INC COM 443510607 353,047 2,580,000 SH   DFND 1, 2 2,580,000 0 0
HUBSPOT INC COM 443573100 376,434 1,288,144 SH   DFND 1, 2 1,288,144 0 0
HUMANA INC COM 444859102 1,999,177 4,830,325 SH   DFND 1, 2 4,826,583 0 3,742
HUNTSMAN CORP COM 447011107 329,924 14,854,734 SH   DFND 1, 2 14,854,734 0 0
HUYA INC ADS REP SHS A 44852D108 191,106 7,979,392 SH   DFND 1, 2 7,979,392 0 0
ICICI BANK LIMITED ADR 45104G104 1,454 147,585 SH   DFND 1, 2 86 0 147,499
IDEX CORP COM 45167R104 464,408 2,545,975 SH   DFND 1, 2 2,540,621 0 5,354
IDEXX LABS INC COM 45168D104 376,210 957,052 SH   DFND 1, 2 955,027 0 2,025
IHEARTMEDIA INC COM CL A 45174J509 3,786 466,239 SH   DFND 1, 2 466,239 0 0
ILLINOIS TOOL WKS INC COM 452308109 577,745 2,990,245 SH   DFND 1, 2 2,990,245 0 0
ILLUMINA INC COM 452327109 807,018 2,611,034 SH   DFND 1, 2 2,611,034 0 0
INCYTE CORP COM 45337C102 35,537 396,000 SH   DFND 1, 2 396,000 0 0
INHIBRX INC COM 45720L107 18,091 1,005,046 SH   DFND 1, 2 1,005,046 0 0
INPHI CORP COM 45772F107 164,921 1,469,229 SH   DFND 1, 2 1,469,229 0 0
INSULET CORP COM 45784P101 1,541,379 6,515,045 SH   DFND 1, 2 6,511,618 0 3,427
INTEL CORP COM 458140100 1,133,417 21,889,479 SH   DFND 1, 2 21,855,501 0 33,978
INTERCONTINENTAL HOTELS GROU SPONSORED ADS 45857P806 531 10,095 SH   DFND 1, 2 9 0 10,086
INTERFACE INC COM 458665304 9,547 1,560,000 SH   DFND 1, 2 1,560,000 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,822,699 18,217,968 SH   DFND 1, 2 18,208,562 0 9,406
INTERNATIONAL BUSINESS MACHS COM 459200101 542,258 4,456,791 SH   DFND 1, 2 4,456,791 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 2,729,918 3,847,525 SH   DFND 1, 2 3,844,245 0 3,280
IRIDIUM COMMUNICATIONS INC COM 46269C102 99,094 3,873,868 SH   DFND 1, 2 3,873,868 0 0
IRON MTN INC NEW COM 46284V101 944,296 35,248,074 SH   DFND 1, 2 35,248,074 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 18,260 2,030,000 SH   DFND 1, 2 2,030,000 0 0
ISHARES TR RUS 1000 VAL ETF 464287598 833 7,102 SH   DFND 1, 2 0 0 7,102
JOYY INC ADS REPSTG COM A 46591M109 245,041 3,037,573 SH   DFND 1, 2 3,037,573 0 0
JPMORGAN CHASE & CO COM 46625H100 7,197,971 74,769,070 SH   DFND 1, 2 74,717,925 0 51,145
JACOBS ENGR GROUP INC COM 469814107 545,666 5,881,921 SH   DFND 1, 2 5,881,921 0 0
JAMF HLDG CORP COM 47074L105 61,417 1,633,000 SH   DFND 1, 2 1,633,000 0 0
JELD-WEN HLDG INC COM 47580P103 9,379 415,000 SH   DFND 1, 2 415,000 0 0
JOHNSON & JOHNSON COM 478160104 3,464,952 23,273,679 SH   DFND 1, 2 23,255,351 0 18,328
KE HLDGS INC SPONSORED ADS 482497104 479,439 7,821,189 SH   DFND 1, 2 7,821,189 0 0
KB HOME COM 48666K109 113,554 2,957,918 SH   DFND 1, 2 2,957,918 0 0
KELLOGG CO COM 487836108 1,023,705 15,849,274 SH   DFND 1, 2 15,849,274 0 0
KEURIG DR PEPPER INC COM 49271V100 1,101,425 39,906,710 SH   DFND 1, 2 39,906,710 0 0
KEYCORP COM 493267108 545,325 45,710,423 SH   DFND 1, 2 45,710,423 0 0
KINSALE CAP GROUP INC COM 49714P108 16,549 87,020 SH   DFND 1, 2 87,020 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 1,033 21,877 SH   DFND 1, 2 12 0 21,865
KONTOOR BRANDS INC COM 50050N103 136,034 5,621,240 SH   DFND 1, 2 5,621,240 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 629,747 3,707,885 SH   DFND 1, 2 3,707,885 0 0
LAM RESEARCH CORP COM 512807108 70,972 213,932 SH   DFND 1, 2 213,932 0 0
LAMAR ADVERTISING CO NEW CL A 512816109 155,719 2,353,322 SH   DFND 1, 2 2,353,322 0 0
LAS VEGAS SANDS CORP COM 517834107 285,135 6,110,903 SH   DFND 1, 2 6,110,903 0 0
LAUDER ESTEE COS INC CL A 518439104 141,105 646,529 SH   DFND 1, 2 646,529 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 31,383 1,016,619 SH   DFND 1, 2 1,016,619 0 0
LEMONADE INC COM 52567D107 20,634 415,000 SH   DFND 1, 2 415,000 0 0
LENNAR CORP CL A 526057104 300,290 3,676,425 SH   DFND 1, 2 3,676,425 0 0
LENNAR CORP CL B 526057302 1,390 21,169 SH   DFND 1, 2 21,169 0 0
LENNOX INTL INC COM 526107107 434,376 1,593,396 SH   DFND 1, 2 1,593,396 0 0
LILLY ELI & CO COM 532457108 455,660 3,078,369 SH   DFND 1, 2 3,078,369 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 186,831 3,467,533 SH   DFND 1, 2 3,467,533 0 0
LIVE NATION ENTERTAINMENT IN NOTE 2.500% 3/1 538034AQ2 6,691 5,980,000 PRN   DFND 1, 2 5,980,000 0 0
LOCKHEED MARTIN CORP COM 539830109 6,431,204 16,779,234 SH   DFND 1, 2 16,768,406 0 10,828
LULULEMON ATHLETICA INC COM 550021109 49,499 150,284 SH   DFND 1, 2 150,284 0 0
M D C HLDGS INC COM 552676108 45,571 967,528 SH   DFND 1, 2 967,528 0 0
MGM GROWTH PPTYS LLC CL A COM 55303A105 129,374 4,623,820 SH   DFND 1, 2 4,623,820 0 0
MACYS INC COM 55616P104 10,830 1,900,000 SH   DFND 1, 2 1,900,000 0 0
MAGNOLIA OIL & GAS CORP CL A 559663109 10,340 2,000,000 SH   DFND 1, 2 2,000,000 0 0
MANPOWERGROUP INC COM 56418H100 107,644 1,467,942 SH   DFND 1, 2 1,467,942 0 0
MANULIFE FINL CORP COM 56501R106 48,593 3,493,760 SH   DFND 1, 2 3,493,760 0 0
MARKETAXESS HLDGS INC COM 57060D108 99,208 206,000 SH   DFND 1, 2 206,000 0 0
MARSH & MCLENNAN COS INC COM 571748102 1,895,554 16,526,333 SH   DFND 1, 2 16,500,918 0 25,415
MARRIOTT INTL INC NEW CL A 571903202 458,901 4,956,805 SH   DFND 1, 2 4,956,805 0 0
MASCO CORP COM 574599106 89,586 1,625,000 SH   DFND 1, 2 1,625,000 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4,875,631 14,417,735 SH   DFND 1, 2 14,410,128 0 7,607
MATCH GROUP INC NEW COM 57667L107 228,800 2,067,780 SH   DFND 1, 2 2,067,780 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 64,906 960,000 SH   DFND 1, 2 960,000 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 329,444 19,786,490 SH   DFND 1, 2 19,765,580 0 20,910
MERCADOLIBRE INC COM 58733R102 2,616,085 2,416,750 SH   DFND 1, 2 2,413,793 0 2,957
MERCK & CO. INC COM 58933Y105 2,153,515 25,961,976 SH   DFND 1, 2 25,932,835 0 29,141
METTLER TOLEDO INTERNATIONAL COM 592688105 344,992 357,227 SH   DFND 1, 2 357,227 0 0
MICROSOFT CORP COM 594918104 23,530,053 111,872,823 SH   DFND 1, 2 111,821,459 0 51,364
MICRON TECHNOLOGY INC COM 595112103 68,679 1,462,496 SH   DFND 1, 2 1,462,496 0 0
MIDDLEBY CORP COM 596278101 62,976 702,000 SH   DFND 1, 2 702,000 0 0
MOELIS & CO CL A 60786M105 25,266 719,000 SH   DFND 1, 2 719,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 1,059,494 5,788,322 SH   DFND 1, 2 5,788,322 0 0
MONDELEZ INTL INC CL A 609207105 1,824,642 31,760,526 SH   DFND 1, 2 31,760,526 0 0
MONEYGRAM INTL INC COM NEW 60935Y208 7,466 2,642,886 SH   DFND 1, 2 2,642,886 0 0
MONGODB INC CL A 60937P106 1,669,523 7,211,450 SH   DFND 1, 2 7,211,450 0 0
MOODYS CORP COM 615369105 485,877 1,676,336 SH   DFND 1, 2 1,674,157 0 2,179
MORGAN STANLEY COM NEW 617446448 284,588 5,886,002 SH   DFND 1, 2 5,886,002 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 977,895 6,236,175 SH   DFND 1, 2 6,236,175 0 0
NMI HLDGS INC CL A 629209305 9,007 506,000 SH   DFND 1, 2 506,000 0 0
NVR INC COM 62944T105 476,455 116,689 SH   DFND 1, 2 116,689 0 0
NASDAQ INC COM 631103108 1,131,657 9,222,205 SH   DFND 1, 2 9,222,205 0 0
NATERA INC COM 632307104 103,231 1,429,000 SH   DFND 1, 2 1,429,000 0 0
NAVIENT CORPORATION COM 63938C108 6,338 750,000 SH   DFND 1, 2 750,000 0 0
NEOVASC INC COM 64065J304 1,947 910,000 SH   DFND 1, 2 910,000 0 0
NETFLIX INC COM 64110L106 6,825,019 13,649,248 SH   DFND 1, 2 13,647,096 0 2,152
NEVRO CORP COM 64157F103 22,288 160,000 SH   DFND 1, 2 160,000 0 0
NEW FORTRESS ENERGY INC COM CL A 644393100 116,891 2,656,000 SH   DFND 1, 2 2,656,000 0 0
NEW YORK TIMES CO CL A 650111107 339,729 7,939,455 SH   DFND 1, 2 7,939,455 0 0
NEXSTAR MEDIA GROUP INC CL A 65336K103 100,739 1,120,199 SH   DFND 1, 2 1,120,199 0 0
NEXTERA ENERGY INC COM 65339F101 14,607 52,626 SH   DFND 1, 2 52,626 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F739 29,295 613,500 SH   DFND 1, 2 613,500 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F770 159,660 3,420,300 SH   DFND 1, 2 3,420,300 0 0
NIKE INC CL B 654106103 2,073,558 16,517,047 SH   DFND 1, 2 16,507,276 0 9,771
NOBLE ENERGY INC COM 655044105 19,024 2,225,000 SH   DFND 1, 2 2,225,000 0 0
NORDSTROM INC COM 655664100 9,059 760,000 SH   DFND 1, 2 760,000 0 0
NORFOLK SOUTHN CORP COM 655844108 1,382,651 6,461,256 SH   DFND 1, 2 6,457,672 0 3,584
NORTHROP GRUMMAN CORP COM 666807102 1,984,061 6,288,603 SH   DFND 1, 2 6,281,444 0 7,159
NORTONLIFELOCK INC COM 668771108 1,533,049 73,562,806 SH   DFND 1, 2 73,562,806 0 0
NOVARTIS AG SPONSORED ADR 66987V109 30,810 354,281 SH   DFND 1, 2 326,614 0 27,667
NOVAVAX INC COM NEW 670002401 125,294 1,156,379 SH   DFND 1, 2 1,156,379 0 0
NOVO-NORDISK A S ADR 670100205 1,403 19,976 SH   DFND 1, 2 11 0 19,965
NU SKIN ENTERPRISES INC CL A 67018T105 30,054 600,000 SH   DFND 1, 2 600,000 0 0
NUCOR CORP COM 670346105 775,178 17,280,023 SH   DFND 1, 2 17,251,071 0 28,952
NUVASIVE INC COM 670704105 37,205 766,000 SH   DFND 1, 2 766,000 0 0
NUTRIEN LTD COM 67077M108 513 13,092 SH   DFND 1, 2 13,092 0 0
OAK STR HEALTH INC COM 67181A107 65,407 1,223,940 SH   DFND 1, 2 1,223,940 0 0
OKTA INC CL A 679295105 106,925 500,000 SH   DFND 1, 2 500,000 0 0
OSHKOSH CORP COM 688239201 55,875 760,207 SH   DFND 1, 2 760,207 0 0
PG&E CORP UNIT 99/99/9999 69331C140 5,920 60,350 SH   DFND 1, 2 60,350 0 0
PGT INNOVATIONS INC COM 69336V101 38,228 2,181,973 SH   DFND 1, 2 2,181,973 0 0
PNC FINL SVCS GROUP INC COM 693475105 1,804,403 16,417,779 SH   DFND 1, 2 16,392,416 0 25,363
PPD INC COM 69355F102 48,564 1,312,907 SH   DFND 1, 2 1,312,907 0 0
PACCAR INC COM 693718108 1,630,290 19,116,909 SH   DFND 1, 2 19,116,909 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 53,752 5,446,000 SH   DFND 1, 2 5,446,000 0 0
PACKAGING CORP AMER COM 695156109 748,552 6,864,303 SH   DFND 1, 2 6,864,303 0 0
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 4,598 4,070,000 PRN   DFND 1, 2 4,070,000 0 0
PARKER-HANNIFIN CORP COM 701094104 579,986 2,866,394 SH   DFND 1, 2 2,866,394 0 0
PARSLEY ENERGY INC CL A 701877102 20,040 2,141,000 SH   DFND 1, 2 2,141,000 0 0
PAYCHEX INC COM 704326107 166,592 2,088,405 SH   DFND 1, 2 2,088,405 0 0
PAYCOM SOFTWARE INC COM 70432V102 330,544 1,061,819 SH   DFND 1, 2 1,061,819 0 0
PAYLOCITY HLDG CORP COM 70438V106 24,213 150,000 SH   DFND 1, 2 150,000 0 0
PAYPAL HLDGS INC COM 70450Y103 3,857,492 19,578,321 SH   DFND 1, 2 19,568,665 0 9,656
PELOTON INTERACTIVE INC CL A COM 70614W100 611,704 6,163,882 SH   DFND 1, 2 6,163,882 0 0
PEMBINA PIPELINE CORP COM 706327103 463 21,827 SH   DFND 1, 2 21,827 0 0
PENN NATL GAMING INC NOTE 2.750% 5/1 707569AU3 7,168 2,230,000 PRN   DFND 1, 2 2,230,000 0 0
PENUMBRA INC COM 70975L107 144,935 745,628 SH   DFND 1, 2 745,628 0 0
PETROLEO BRASILEIRO SA PETRO SP ADR NON VTG 71654V101 180,023 25,571,417 SH   DFND 1, 2 25,571,417 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 453,387 63,679,105 SH   DFND 1, 2 63,613,003 0 66,102
PFIZER INC COM 717081103 9,512,064 259,186,297 SH   DFND 1, 2 259,048,546 0 137,751
PHILIP MORRIS INTL INC COM 718172109 6,246,817 83,301,997 SH   DFND 1, 2 83,301,997 0 0
PIONEER NAT RES CO COM 723787107 273,973 3,186,099 SH   DFND 1, 2 3,186,099 0 0
POLARIS INC COM 731068102 45,755 485,000 SH   DFND 1, 2 485,000 0 0
POOL CORP COM 73278L105 137,061 409,700 SH   DFND 1, 2 409,700 0 0
PRECISION BIOSCIENCES INC COM 74019P108 25,022 4,062,000 SH   DFND 1, 2 4,062,000 0 0
PROCTER AND GAMBLE CO COM 742718109 1,332,995 9,590,581 SH   DFND 1, 2 9,590,581 0 0
PROGRESSIVE CORP COM 743315103 760,394 8,032,048 SH   DFND 1, 2 8,032,048 0 0
PROLOGIS INC. COM 74340W103 467,883 4,650,000 SH   DFND 1, 2 4,650,000 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 794,127 14,462,336 SH   DFND 1, 2 14,462,336 0 0
PUBLIC STORAGE COM 74460D109 360,472 1,618,500 SH   DFND 1, 2 1,618,500 0 0
QUALCOMM INC COM 747525103 1,209,203 10,275,345 SH   DFND 1, 2 10,275,345 0 0
RH COM 74967X103 41,323 108,000 SH   DFND 1, 2 108,000 0 0
RADIAN GROUP INC COM 750236101 12,930 885,000 SH   DFND 1, 2 885,000 0 0
RATTLER MIDSTREAM LP COM UNITS 75419T103 17,016 2,859,750 SH   DFND 1, 2 2,859,750 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 656,588 11,410,975 SH   DFND 1, 2 11,410,975 0 0
REDWOOD TR INC COM 758075402 19,266 2,562,000 SH   DFND 1, 2 2,562,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 3,719,415 6,644,370 SH   DFND 1, 2 6,642,203 0 2,167
REGIONS FINANCIAL CORP NEW COM 7591EP100 510,024 44,234,540 SH   DFND 1, 2 44,234,540 0 0
REPAY HLDGS CORP COM CL A 76029L100 54,259 2,308,908 SH   DFND 1, 2 2,308,908 0 0
REPUBLIC SVCS INC COM 760759100 130,811 1,401,292 SH   DFND 1, 2 1,401,292 0 0
RESMED INC COM 761152107 915,168 5,338,434 SH   DFND 1, 2 5,338,434 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 1,853,121 32,227,408 SH   DFND 1, 2 32,213,268 0 14,140
REVANCE THERAPEUTICS INC COM 761330109 53,548 2,130,000 SH   DFND 1, 2 2,130,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 42,734 1,228,000 SH   DFND 1, 2 1,228,000 0 0
REXNORD CORP COM 76169B102 144,068 4,828,000 SH   DFND 1, 2 4,828,000 0 0
RINGCENTRAL INC CL A 76680R206 2,981,161 10,855,983 SH   DFND 1, 2 10,855,983 0 0
RIO TINTO PLC SPONSORED ADR 767204100 889 14,766 SH   DFND 1, 2 8 0 14,758
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 156,625 6,466,743 SH   DFND 1, 2 6,466,743 0 0
ROYAL GOLD INC COM 780287108 906,520 7,543,649 SH   DFND 1, 2 7,543,649 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 5,596 1,117,000 SH   DFND 1, 2 1,117,000 0 0
S&P GLOBAL INC COM 78409V104 1,391,741 3,859,516 SH   DFND 1, 2 3,859,516 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 629 1,891 SH   DFND 1, 2 0 0 1,891
SPDR INDEX SHS FDS MSCI ACWI EXUS 78463X848 515 21,459 SH   DFND 1, 2 0 0 21,459
SVB FINANCIAL GROUP COM 78486Q101 236,072 981,100 SH   DFND 1, 2 981,100 0 0
SAIA INC COM 78709Y105 87,037 690,000 SH   DFND 1, 2 690,000 0 0
SAILPOINT TECHNLGIES HLDGS I COM 78781P105 88,110 2,226,696 SH   DFND 1, 2 2,226,696 0 0
SAP SE SPON ADR 803054204 1,719 10,981 SH   DFND 1, 2 6 0 10,975
SEA LTD SPONSORD ADS 81141R100 3,172,734 20,596,678 SH   DFND 1, 2 20,577,299 0 19,379
SEACOAST BKG CORP FLA COM NEW 811707801 64,582 3,581,901 SH   DFND 1, 2 3,581,901 0 0
SEATTLE GENETICS INC COM 812578102 57,407 293,355 SH   DFND 1, 2 293,355 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 26,720 670,000 SH   DFND 1, 2 670,000 0 0
SERVICENOW INC COM 81762P102 805,288 1,660,381 SH   DFND 1, 2 1,659,290 0 1,091
SHAW COMMUNICATIONS INC CL B CONV 82028K200 138,978 7,615,497 SH   DFND 1, 2 7,615,497 0 0
SHERWIN WILLIAMS CO COM 824348106 2,215,984 3,180,489 SH   DFND 1, 2 3,179,331 0 1,158
SHOCKWAVE MED INC COM 82489T104 44,343 585,000 SH   DFND 1, 2 585,000 0 0
SHOPIFY INC CL A 82509L107 5,951,351 5,817,720 SH   DFND 1, 2 5,812,973 0 4,747
SILK RD MED INC COM 82710M100 145,567 2,165,850 SH   DFND 1, 2 2,165,850 0 0
SIMON PPTY GROUP INC NEW COM 828806109 463,091 7,159,727 SH   DFND 1, 2 7,159,711 0 16
SIMPLY GOOD FOODS CO COM 82900L102 109,170 4,951,000 SH   DFND 1, 2 4,951,000 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 30,734 1,514,000 SH   DFND 1, 2 1,514,000 0 0
SMARTSHEET INC COM CL A 83200N103 708,706 14,340,317 SH   DFND 1, 2 14,331,249 0 9,068
SNAP INC CL A 83304A106 1,039,353 39,806,684 SH   DFND 1, 2 39,806,684 0 0
SNOWFLAKE INC CL A 833445109 179,297 714,329 SH   DFND 1, 2 714,329 0 0
SOLARIS OILFIELD INFRSTR INC COM CL A 83418M103 4,379 690,675 SH   DFND 1, 2 690,675 0 0
SOUTH ST CORP COM 840441109 22,667 470,765 SH   DFND 1, 2 470,765 0 0
SOUTHWEST AIRLS CO COM 844741108 124,283 3,314,209 SH   DFND 1, 2 3,314,209 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 7,467 5,700,000 PRN   DFND 1, 2 5,700,000 0 0
SOUTHWESTERN ENERGY CO COM 845467109 539 229,524 SH   DFND 1, 2 229,524 0 0
SQUARE INC CL A 852234103 1,273,767 7,836,158 SH   DFND 1, 2 7,836,158 0 0
STARBUCKS CORP COM 855244109 65,019 756,737 SH   DFND 1, 2 756,737 0 0
STERICYCLE INC COM 858912108 27,116 430,000 SH   DFND 1, 2 430,000 0 0
STEPSTONE GROUP INC COM CL A 85914M107 18,627 700,000 SH   DFND 1, 2 700,000 0 0
STRATEGIC ED INC COM 86272C103 141,138 1,543,000 SH   DFND 1, 2 1,543,000 0 0
SUN CMNTYS INC COM 866674104 686,451 4,881,949 SH   DFND 1, 2 4,881,949 0 0
SUNCOR ENERGY INC NEW COM 867224107 116,273 9,521,695 SH   DFND 1, 2 9,521,695 0 0
SYNCHRONY FINANCIAL COM 87165B103 1,264,912 48,334,436 SH   DFND 1, 2 48,334,436 0 0
TJX COS INC NEW COM 872540109 100,297 1,802,282 SH   DFND 1, 2 1,802,282 0 0
T-MOBILE US INC COM 872590104 2,649,613 23,169,050 SH   DFND 1, 2 23,169,050 0 0
TTM TECHNOLOGIES INC COM 87305R109 13,315 1,167,000 SH   DFND 1, 2 1,167,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 3,282,518 40,490,588 SH   DFND 1, 2 40,394,306 0 96,282
TANDEM DIABETES CARE INC COM NEW 875372203 176,480 1,554,889 SH   DFND 1, 2 1,554,889 0 0
TARGET CORP COM 87612E106 1,631,108 10,361,505 SH   DFND 1, 2 10,361,505 0 0
TC ENERGY CORP COM 87807B107 673,286 16,035,345 SH   DFND 1, 2 16,004,753 0 30,592
TELADOC HEALTH INC COM 87918A105 588,906 2,686,127 SH   DFND 1, 2 2,686,127 0 0
TELUS CORPORATION COM 87971M103 61,030 3,468,408 SH   DFND 1, 2 3,468,408 0 0
10X GENOMICS INC CL A COM 88025U109 159,200 1,276,870 SH   DFND 1, 2 1,276,870 0 0
TESLA INC COM 88160R101 22,414,996 52,248,658 SH   DFND 1, 2 52,228,440 0 20,218
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 475,779 52,806,500 SH   DFND 1, 2 52,756,789 0 49,711
TEXAS INSTRS INC COM 882508104 1,568,361 10,983,853 SH   DFND 1, 2 10,965,886 0 17,967
TEXTRON INC COM 883203101 28,150 780,000 SH   DFND 1, 2 780,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,074,458 16,023,033 SH   DFND 1, 2 16,018,634 0 4,399
TOLL BROTHERS INC COM 889478103 606,914 12,472,537 SH   DFND 1, 2 12,472,537 0 0
TOPBUILD CORP COM 89055F103 229,032 1,341,800 SH   DFND 1, 2 1,341,800 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 868,179 18,751,613 SH   DFND 1, 2 18,721,829 0 29,784
TRADEWEB MKTS INC CL A 892672106 252,653 4,356,088 SH   DFND 1, 2 4,356,088 0 0
TRANSDIGM GROUP INC COM 893641100 449,112 945,261 SH   DFND 1, 2 945,261 0 0
TRUPANION INC COM 898202106 220,566 2,795,507 SH   DFND 1, 2 2,795,507 0 0
TRUIST FINL CORP COM 89832Q109 509,150 13,381,079 SH   DFND 1, 2 13,381,079 0 0
TURQUOISE HILL RES LTD COM 900435108 24,318 28,792,379 SH   DFND 1, 2 28,792,379 0 0
TWIST BIOSCIENCE CORP COM 90184D100 122,308 1,609,952 SH   DFND 1, 2 1,609,952 0 0
TWITTER INC COM 90184L102 318,520 7,157,745 SH   DFND 1, 2 7,157,745 0 0
TYLER TECHNOLOGIES INC COM 902252105 355,361 1,019,511 SH   DFND 1, 2 1,019,511 0 0
UBER TECHNOLOGIES INC COM 90353T100 632,025 17,325,257 SH   DFND 1, 2 17,325,257 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 266,087 3,237,461 SH   DFND 1, 2 3,237,461 0 0
UMPQUA HLDGS CORP COM 904214103 18,962 1,785,500 SH   DFND 1, 2 1,785,500 0 0
UNILEVER PLC SPON ADR NEW 904767704 98,744 1,600,900 SH   DFND 1, 2 1,600,900 0 0
UNILEVER N V N Y SHS NEW 904784709 42,170 698,186 SH   DFND 1, 2 698,186 0 0
UNION PAC CORP COM 907818108 1,595,737 8,105,531 SH   DFND 1, 2 8,101,961 0 3,570
UNITED PARCEL SERVICE INC CL B 911312106 1,146,509 6,880,568 SH   DFND 1, 2 6,880,568 0 0
UNITED RENTALS INC COM 911363109 98,110 562,234 SH   DFND 1, 2 562,234 0 0
UNITEDHEALTH GROUP INC COM 91324P102 11,708,060 37,553,956 SH   DFND 1, 2 37,535,951 0 18,005
V F CORP COM 918204108 664,200 9,454,962 SH   DFND 1, 2 9,436,888 0 18,074
VAIL RESORTS INC COM 91879Q109 36,803 172,000 SH   DFND 1, 2 172,000 0 0
VALE S A SPONSORED ADS 91912E105 1,002,705 94,775,455 SH   DFND 1, 2 94,664,433 0 111,022
VALERO ENERGY CORP COM 91913Y100 546,549 12,616,549 SH   DFND 1, 2 12,616,549 0 0
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 305 3,801 SH   DFND 1, 2 0 0 3,801
VEECO INSTRS INC DEL COM 922417100 11,986 1,027,109 SH   DFND 1, 2 1,027,109 0 0
VERISIGN INC COM 92343E102 111,650 545,031 SH   DFND 1, 2 545,031 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 3,767,120 63,323,757 SH   DFND 1, 2 63,283,489 0 40,268
VERTEX PHARMACEUTICALS INC COM 92532F100 3,091,419 11,360,515 SH   DFND 1, 2 11,358,370 0 2,145
VERTIV HOLDINGS CO COM CL A 92537N108 136,889 7,903,500 SH   DFND 1, 2 7,903,500 0 0
VIAVI SOLUTIONS INC COM 925550105 67,236 5,732,000 SH   DFND 1, 2 5,732,000 0 0
VIACOMCBS INC CL B 92556H206 145,166 5,182,640 SH   DFND 1, 2 5,182,640 0 0
VICI PPTYS INC COM 925652109 65,553 2,805,000 SH   DFND 1, 2 2,805,000 0 0
VICTORY CAP HLDGS INC COM CL A 92645B103 13,715 812,000 SH   DFND 1, 2 812,000 0 0
VIPER ENERGY PARTNERS LP COM UNT RP INT 92763M105 10,942 1,455,000 SH   DFND 1, 2 1,455,000 0 0
VISA INC COM CL A 92826C839 3,152,079 15,762,793 SH   DFND 1, 2 15,749,998 0 12,795
VISTRA CORP COM 92840M102 6,967 369,425 SH   DFND 1, 2 369,425 0 0
VMWARE INC CL A COM 928563402 397,068 2,763,749 SH   DFND 1, 2 2,763,749 0 0
VULCAN MATLS CO COM 929160109 883,243 6,516,475 SH   DFND 1, 2 6,516,475 0 0
VROOM INC COM 92918V109 15,741 304,000 SH   DFND 1, 2 304,000 0 0
WADDELL & REED FINL INC CL A 930059100 27,473 1,850,000 SH   DFND 1, 2 1,850,000 0 0
WALMART INC COM 931142103 332,020 2,373,094 SH   DFND 1, 2 2,373,094 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 555,844 15,474,486 SH   DFND 1, 2 15,474,486 0 0
WARNER MUSIC GROUP CORP COM CL A 934550203 64,284 2,236,728 SH   DFND 1, 2 2,236,728 0 0
WASTE CONNECTIONS INC COM 94106B101 102,175 984,345 SH   DFND 1, 2 984,345 0 0
WASTE MGMT INC DEL COM 94106L109 322,698 2,851,441 SH   DFND 1, 2 2,851,441 0 0
WATSCO INC COM 942622200 240,026 1,030,641 SH   DFND 1, 2 1,030,641 0 0
WAYFAIR INC CL A 94419L101 210,440 723,136 SH   DFND 1, 2 723,136 0 0
WESTLAKE CHEM CORP COM 960413102 307,456 4,863,274 SH   DFND 1, 2 4,863,274 0 0
WESTROCK CO COM 96145D105 138,960 4,000,000 SH   DFND 1, 2 4,000,000 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 720,676 14,686,687 SH   DFND 1, 2 14,686,687 0 0
WHITING PETE CORP NEW COM NEW 966387508 3,777 218,460 SH   DFND 1, 2 218,460 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 59,871 3,589,400 SH   DFND 1, 2 3,589,400 0 0
WINNEBAGO INDS INC COM 974637100 14,252 275,820 SH   DFND 1, 2 275,820 0 0
WORKDAY INC CL A 98138H101 84,663 393,545 SH   DFND 1, 2 393,545 0 0
WORLD WRESTLING ENTMT INC CL A 98156Q108 27,196 672,000 SH   DFND 1, 2 672,000 0 0
WYNN RESORTS LTD COM 983134107 119,735 1,667,381 SH   DFND 1, 2 1,667,375 0 6
XCEL ENERGY INC COM 98389B100 1,393,257 20,189,356 SH   DFND 1, 2 20,160,364 0 28,992
XENON PHARMACEUTICALS INC COM 98420N105 10,666 963,500 SH   DFND 1, 2 963,500 0 0
XPENG INC ADS 98422D105 170,942 8,517,268 SH   DFND 1, 2 8,517,268 0 0
YEXT INC COM 98585N106 120,230 7,920,309 SH   DFND 1, 2 7,920,309 0 0
YETI HLDGS INC COM 98585X104 34,307 757,000 SH   DFND 1, 2 757,000 0 0
YUM BRANDS INC COM 988498101 266,042 2,913,930 SH   DFND 1, 2 2,913,930 0 0
ZAI LAB LTD ADR 98887Q104 577,749 6,946,604 SH   DFND 1, 2 6,946,604 0 0
ZENDESK INC COM 98936J101 510,959 4,964,624 SH   DFND 1, 2 4,964,624 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 21,706 664,000 SH   DFND 1, 2 664,000 0 0
ZILLOW GROUP INC CL A 98954M101 136,071 1,340,077 SH   DFND 1, 2 1,340,077 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 303,617 2,988,647 SH   DFND 1, 2 2,988,647 0 0
ZOETIS INC CL A 98978V103 1,479,842 8,948,806 SH   DFND 1, 2 8,941,174 0 7,632
ZOOMINFO TECHNOLOGIES INC COM CL A 98980F104 210,854 4,904,732 SH   DFND 1, 2 4,904,732 0 0
EURONAV NV SHS B38564108 6,623 750,000 SH   DFND 1, 2 750,000 0 0
AON PLC SHS CL A G0403H108 1,448,845 7,023,000 SH   DFND 1, 2 7,023,000 0 0
ARCH CAP GROUP LTD ORD G0450A105 556,080 19,011,286 SH   DFND 1, 2 19,011,286 0 0
ARCO PLATFORM LTD COM CL A G04553106 63,813 1,562,501 SH   DFND 1, 2 1,562,501 0 0
ATLASSIAN CORP PLC CL A G06242104 2,363 13,000 SH   DFND 1, 2 13,000 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208 41,218 1,850,000 SH   DFND 1, 2 1,850,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 215,116 3,308,975 SH   DFND 1, 2 3,308,975 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 103,779 459,218 SH   DFND 1, 2 459,218 0 0
BROOKFIELD PROPERTY PARTRS L UNIT LTD PARTN G16249107 28,489 2,368,154 SH   DFND 1, 2 2,368,154 0 0
BROOKFIELD INFRAST PARTNERS LP INT UNIT G16252101 883,169 18,522,346 SH   DFND 1, 2 18,522,346 0 0
CLARIVATE PLC ORD SHS G21810109 109,242 3,525,084 SH   DFND 1, 2 3,525,084 0 0
CREDICORP LTD COM G2519Y108 8,615 69,481 SH   DFND 1, 2 69,481 0 0
COCA COLA EUROPEAN PARTNERS SHS G25839104 138,831 3,577,186 SH   DFND 1, 2 3,577,186 0 0
EATON CORP PLC SHS G29183103 5,418 53,100 SH   DFND 1, 2 53,100 0 0
ENSTAR GROUP LIMITED SHS G3075P101 87,937 544,500 SH   DFND 1, 2 544,500 0 0
ESSENT GROUP LTD COM G3198U102 70,247 1,898,064 SH   DFND 1, 2 1,898,064 0 0
FRESH DEL MONTE PRODUCE INC ORD G36738105 23,562 1,028,000 SH   DFND 1, 2 1,028,000 0 0
JANUS HENDERSON GROUP PLC ORD SHS G4474Y214 26,065 1,200,041 SH   DFND 1, 2 1,200,041 0 0
JOHNSON CTLS INTL PLC SHS G51502105 58,979 1,443,743 SH   DFND 1, 2 1,425,620 0 18,123
LINDE PLC SHS G5494J103 3,033,277 12,742,950 SH   DFND 1, 2 12,727,132 0 15,818
NOMAD FOODS LTD USD ORD SHS G6564A105 12,740 500,000 SH   DFND 1, 2 500,000 0 0
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 18,821 1,100,000 SH   DFND 1, 2 1,100,000 0 0
NOVOCURE LTD ORD SHS G6674U108 737,987 6,630,017 SH   DFND 1, 2 6,630,017 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 769,195 20,397,702 SH   DFND 1, 2 20,383,792 0 13,910
RENAISSANCERE HLDGS LTD COM G7496G103 410,190 2,416,578 SH   DFND 1, 2 2,416,578 0 0
VENATOR MATLS PLC SHS G9329Z100 15,195 7,873,182 SH   DFND 1, 2 7,873,182 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 409,382 1,960,454 SH   DFND 1, 2 1,960,454 0 0
CHUBB LIMITED COM H1467J104 1,374,753 11,839,423 SH   DFND 1, 2 11,816,753 0 22,670
LOGITECH INTL S A SHS H50430232 473,134 6,114,019 SH   DFND 1, 2 6,114,019 0 0
TE CONNECTIVITY LTD REG SHS H84989104 1,747,078 17,874,745 SH   DFND 1, 2 17,874,745 0 0
GLOBANT S A COM L44385109 115,234 642,973 SH   DFND 1, 2 642,973 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 37,384 154,118 SH   DFND 1, 2 154,118 0 0
JFROG LTD ORD SHS M6191J100 42,325 500,000 SH   DFND 1, 2 500,000 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 2,985,103 8,083,480 SH   DFND 1, 2 8,058,853 0 24,627
FERRARI N V COM N3167Y103 184,444 1,007,610 SH   DFND 1, 2 1,002,373 0 5,237
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 1,231,818 17,475,100 SH   DFND 1, 2 17,464,204 0 10,896
WRIGHT MED GROUP N V ORD SHS N96617118 26,871 879,857 SH   DFND 1, 2 879,857 0 0
YANDEX N V SHS CLASS A N97284108 693,535 10,628,891 SH   DFND 1, 2 10,628,891 0 0
SCORPIO TANKERS INC SHS Y7542C130 3,819 345,000 SH   DFND 1, 2 345,000 0 0