The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105 47,916 9,818,758 SH   DFND 1 0 9,818,758 0
ALX ONCOLOGY HLDGS INC COM 00166B105 24,113 638,928 SH   DFND 1 0 638,928 0
AMARIN CORP PLC SPONS ADR NEW 023111206 4,631 1,100,000 SH   DFND 1 0 1,100,000 0
ANAPTYSBIO INC COM 032724106 18,104 1,227,405 SH   DFND 1 0 1,227,405 0
ARCUS BIOSCIENCES INC COM 03969F109 44,516 2,597,222 SH   DFND 1 0 2,597,222 0
ARGENX SE SPONSORED ADR 04016X101 44,523 169,600 SH   DFND 1 0 169,600 0
BCTG ACQUISITION CORP COM 05492W103 8,288 800,000 SH   DFND 1 0 800,000 0
BIOLINERX LTD SPONSORED ADS 09071M205 2,766 1,686,375 SH   DFND 1 0 1,686,375 0
CALITHERA BIOSCIENCES INC COM 13089P101 15,820 4,585,638 SH   DFND 1 0 4,585,638 0
CALLIDITAS THERAPEUTICS AB SPONSORED ADS 13124Q106 18,000 750,000 SH   DFND 1 0 750,000 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 45,481 3,066,797 SH   DFND 1 0 3,066,797 0
CIDARA THERAPEUTICS INC COM 171757107 10,735 3,766,704 SH   DFND 1 0 3,766,704 0
CONTRAFECT CORP COM NEW 212326300 8,448 1,600,000 SH   DFND 1 0 1,600,000 0
CORVUS PHARMACEUTICALS INC COM 221015100 6,992 1,743,712 SH   DFND 1 0 1,743,712 0
CTI BIOPHARMA CORP COM 12648L601 14,899 6,929,690 SH   DFND 1 0 6,929,690 0
CURIS INC COM NEW 231269200 4,271 3,650,000 SH   DFND 1 0 3,650,000 0
CYTOKINETICS INC COM NEW 23282W605 71,944 3,323,051 SH   DFND 1 0 3,323,051 0
CYTOMX THERAPEUTICS INC COM 23284F105 23,672 3,559,722 SH   DFND 1 0 3,559,722 0
ERYTECH PHARMA SPONSORED ADR 29604W108 3,906 625,000 SH   DFND 1 0 625,000 0
ESSA PHARMA INC COM NEW 29668H708 20,739 3,005,589 SH   DFND 1 0 3,005,589 0
EVELO BIOSCIENCES INC COM 299734103 6,851 1,300,000 SH   DFND 1 0 1,300,000 0
EXELIXIS INC COM 30161Q104 374 15,300 SH   DFND 1 0 15,300 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 37,644 8,009,353 SH   DFND 1 0 8,009,353 0
FORTE BIOSCIENCES INC COM 34962G109 37,719 777,553 SH   DFND 1 0 777,553 0
FORWARD PHARMA A/S SPONSORD ADS NEW 34986J204 4,033 647,299 SH   DFND 1 0 647,299 0
GALMED PHARMACEUTICALS LTD SHS M47238106 6,353 1,799,694 SH   DFND 1 0 1,799,694 0
GAMIDA CELL LTD SHS M47364100 8,896 2,143,667 SH   DFND 1 0 2,143,667 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 9,188 4,012,404 SH   DFND 1 0 4,012,404 0
GLYCOMIMETICS INC COM 38000Q102 22,240 7,244,262 SH   DFND 1 0 7,244,262 0
IDEAYA BIOSCIENCES INC COM 45166A102 40,528 3,226,769 SH   DFND 1 0 3,226,769 0
IMMUNOVANT INC COM 45258J102 42,173 1,198,427 SH   DFND 1 0 1,198,427 0
INFINITY PHARMACEUTICALS INC COM 45665G303 20,390 17,426,968 SH   DFND 1 0 17,426,968 0
IONIS PHARMACEUTICALS INC COM 462222100 34,878 735,055 SH   DFND 1 0 735,055 0
KURA ONCOLOGY INC COM 50127T109 45,626 1,489,112 SH   DFND 1 0 1,489,112 0
KYMERA THERAPEUTICS INC COM 501575104 84,997 2,630,658 SH   DFND 1 0 2,630,658 0
MEI PHARMA INC COM NEW 55279B202 12,730 4,080,162 SH   DFND 1 0 4,080,162 0
MERUS N V COM N5749R100 67,747 5,645,571 SH   DFND 1 0 5,645,571 0
MOLECULAR TEMPLATES INC COM 608550109 23,468 2,149,057 SH   DFND 1 0 2,149,057 0
NOVUS THERAPEUTICS INC COM 67011N105 3,340 3,515,873 SH   DFND 1 0 3,515,873 0
OVID THERAPEUTICS INC COM 690469101 20,791 3,622,051 SH   DFND 1 0 3,622,051 0
PANACEA ACQUISITION CORP UNIT 99/99/9999 698102209 9,600 800,000 SH   DFND 1 0 800,000 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 11,811 322,098 SH   DFND 1 0 322,098 0
PIERIS PHARMACEUTICALS INC COM 720795103 11,374 5,494,582 SH   DFND 1 0 5,494,582 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 46,378 2,372,288 SH   DFND 1 0 2,372,288 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 1,654 3,217,480 SH   DFND 1 0 3,217,480 0
RELAY THERAPEUTICS INC COM 75943R102 143,885 3,378,380 SH   DFND 1 0 3,378,380 0
REPARE THERAPEUTICS INC COM 760273102 94,302 3,064,734 SH   DFND 1 0 3,064,734 0
REPLIMUNE GROUP INC COM 76029N106 38,946 1,691,834 SH   DFND 1 0 1,691,834 0
REVOLUTION MEDICINES INC COM 76155X100 73,117 2,101,049 SH   DFND 1 0 2,101,049 0
SELECTA BIOSCIENCES INC COM 816212104 20,980 8,459,547 SH   DFND 1 0 8,459,547 0
SPERO THERAPEUTICS INC COM 84833T103 15,003 1,344,334 SH   DFND 1 0 1,344,334 0
SPRING BK PHARMACEUTICALS IN COM 849431101 1,261 941,171 SH   DFND 1 0 941,171 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 97,914 2,053,991 SH   DFND 1 0 2,053,991 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328874 2,159 1,727,308 SH   DFND 1 0 1,727,308 0
SUTRO BIOPHARMA INC COM 869367102 31,026 3,087,195 SH   DFND 1 0 3,087,195 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 36,467 2,470,678 SH   DFND 1 0 2,470,678 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 14,380 1,000,000 SH   DFND 1 0 1,000,000 0
VERASTEM INC COM 92337C104 13,005 10,747,994 SH   DFND 1 0 10,747,994 0
X4 PHARMACEUTICALS INC COM 98420X103 5,368 792,892 SH   DFND 1 0 792,892 0
XENCOR INC COM 98401F105 80,222 2,068,098 SH   DFND 1 0 2,068,098 0
XENON PHARMACEUTICALS INC COM 98420N105 38,738 3,499,346 SH   DFND 1 0 3,499,346 0
XOMA CORP DEL COM NEW 98419J206 78,793 4,182,243 SH   DFND 1 0 4,182,243 0