The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc Class A CL A COM 88025U109 33,045 265,036 SH   DFND 1 265,036 0 0
10X Genomics Inc Class A CL A COM 88025U109 12,927 103,682 SH   DFND 2 82,225 0 21,457
10X Genomics Inc Class A CL A COM 88025U109 17,795 142,729 SH   DFND 3 81,689 0 61,040
AJ Gallagher & Co COM 363576109 122,032 1,155,821 SH   DFND 1 1,155,821 0 0
AJ Gallagher & Co COM 363576109 395,934 3,750,082 SH   DFND 2 3,485,161 0 264,921
AJ Gallagher & Co COM 363576109 80,388 761,390 SH   DFND 3 344,999 0 416,391
AJ Gallagher & Co COM 363576109 265,018 2,510,114 SH   SOLE 0 2,333,045 0 177,069
Abiomed COM 003654100 248,821 898,076 SH   DFND 1 898,076 0 0
Abiomed COM 003654100 348,632 1,258,327 SH   DFND 2 1,169,081 0 89,246
Abiomed COM 003654100 63,353 228,662 SH   DFND 3 122,605 0 106,057
Abiomed COM 003654100 155,206 560,188 SH   SOLE 0 529,404 0 30,784
Activision Blizzard Inc COM 00507V109 13,058 161,314 SH   DFND 2 161,314 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 27,472 3,442,664 SH   DFND 1 3,442,664 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 11,962 1,499,051 SH   DFND 2 554,053 0 944,998
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 4,214 528,086 SH   DFND 3 528,086 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 12,834 1,608,262 SH   SOLE 0 1,608,262 0 0
Adicet Bio Inc COM 007002108 1,111 93,449 SH   DFND 1 93,449 0 0
Adicet Bio Inc COM 007002108 1,048 88,177 SH   SOLE 0 88,177 0 0
Aerovironment COM 008073108 21,035 350,517 SH   DFND 1 350,517 0 0
Aerovironment COM 008073108 15,184 253,019 SH   DFND 2 93,275 0 159,744
Aerovironment COM 008073108 5,332 88,858 SH   DFND 3 88,858 0 0
Aerovironment COM 008073108 13,236 220,567 SH   SOLE 0 220,567 0 0
Agora Inc ADR ADS 00851L103 9,975 232,088 SH   DFND 1 232,088 0 0
Agora Inc ADR ADS 00851L103 7,217 167,912 SH   SOLE 0 167,912 0 0
Albemarle Corp COM 012653101 60,311 675,524 SH   DFND 1 675,524 0 0
Albemarle Corp COM 012653101 166,927 1,869,703 SH   DFND 2 1,728,546 0 141,157
Albemarle Corp COM 012653101 34,510 386,542 SH   DFND 3 174,196 0 212,346
Albemarle Corp COM 012653101 125,129 1,401,534 SH   SOLE 0 1,310,750 0 90,784
Alector Inc COM 014442107 485 46,047 SH   DFND 2 46,047 0 0
Alector Inc COM 014442107 188 17,811 SH   DFND 3 17,811 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 713,488 2,426,995 SH   DFND 1 2,426,995 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 3,747,861 12,748,693 SH   DFND 2 6,749,830 0 5,998,863
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 335,530 1,141,335 SH   DFND 3 733,461 0 407,874
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 2,562,002 8,714,887 SH   SOLE 0 7,234,519 0 1,480,368
Align Technology Inc COM 016255101 11,026 33,681 SH   DFND 2 33,681 0 0
Alnylam Pharmaceuticals COM 02043Q107 319,608 2,195,112 SH   DFND 1 2,195,112 0 0
Alnylam Pharmaceuticals COM 02043Q107 529,113 3,634,017 SH   DFND 2 3,050,088 0 583,929
Alnylam Pharmaceuticals COM 02043Q107 117,040 803,849 SH   DFND 3 504,728 0 299,121
Alnylam Pharmaceuticals COM 02043Q107 328,839 2,258,510 SH   SOLE 0 2,154,864 0 103,646
Alphabet Inc Class A CAP STK CL A 02079K305 58,263 39,754 SH   DFND 1 39,754 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 79,106 53,975 SH   DFND 2 41,495 0 12,480
Alphabet Inc Class A CAP STK CL A 02079K305 28,194 19,237 SH   DFND 3 10,749 0 8,488
Alphabet Inc Class A CAP STK CL A 02079K305 115,035 78,490 SH   SOLE 0 78,490 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 567,690 386,289 SH   DFND 1 386,289 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,725,321 1,174,007 SH   DFND 2 776,003 0 398,004
Alphabet Inc Class C CAP STK CL C 02079K107 215,238 146,460 SH   DFND 3 83,573 0 62,887
Alphabet Inc Class C CAP STK CL C 02079K107 917,736 624,480 SH   SOLE 0 508,515 0 115,965
Amazon.Com COM 023135106 1,380,661 438,482 SH   DFND 1 438,482 0 0
Amazon.Com COM 023135106 6,163,900 1,957,583 SH   DFND 2 1,285,118 0 672,465
Amazon.Com COM 023135106 439,519 139,586 SH   DFND 3 92,715 0 46,871
Amazon.Com COM 023135106 3,344,272 1,062,102 SH   SOLE 0 893,888 0 168,214
Ambarella SHS G037AX101 11,281 216,200 SH   DFND 1 216,200 0 0
Ambarella SHS G037AX101 7,254 139,028 SH   DFND 2 51,029 0 87,999
Ambarella SHS G037AX101 2,513 48,166 SH   DFND 3 48,166 0 0
Ambarella SHS G037AX101 5,093 97,605 SH   SOLE 0 97,605 0 0
Ameren COM 023608102 45,263 572,364 SH   DFND 1 572,364 0 0
Ameren COM 023608102 91 1,150 SH   DFND 2 1,150 0 0
Ameren COM 023608102 2,336 29,546 SH   DFND 3 29,546 0 0
American Electric Power COM 025537101 50,763 621,100 SH   DFND 1 621,100 0 0
American Electric Power COM 025537101 94 1,148 SH   DFND 2 1,148 0 0
American Electric Power COM 025537101 2,604 31,858 SH   DFND 3 31,858 0 0
American Express COM 025816109 14,214 141,786 SH   DFND 2 141,786 0 0
American Superconductor Corp COM 030111207 7,490 517,270 SH   SOLE 0 517,270 0 0
American Well Corp Class A COM 03044L105 2,016 68,000 SH   DFND 2 68,000 0 0
American Well Corp Class A COM 03044L105 821 27,700 SH   DFND 3 27,700 0 0
Analog Devices COM 032654105 18,649 159,746 SH   DFND 1 159,746 0 0
Analog Devices COM 032654105 755 6,469 SH   DFND 2 0 0 6,469
Analog Devices COM 032654105 29 245 SH   DFND 3 245 0 0
Analog Devices COM 032654105 19,329 165,575 SH   SOLE 0 165,575 0 0
Anaplan Inc Common COM 03272L108 117,127 1,871,644 SH   SOLE 0 1,871,644 0 0
Annaly Capital Man. COM 035710409 53 7,446 SH   DFND 1 7,446 0 0
Anthem Inc COM 036752103 143,869 535,646 SH   DFND 1 535,646 0 0
Anthem Inc COM 036752103 501,628 1,867,636 SH   DFND 2 1,732,701 0 134,935
Anthem Inc COM 036752103 105,258 391,892 SH   DFND 3 177,378 0 214,514
Anthem Inc COM 036752103 335,248 1,248,176 SH   SOLE 0 1,155,484 0 92,692
Appian Corp CL A 03782L101 151,689 2,342,684 SH   DFND 1 2,342,684 0 0
Appian Corp CL A 03782L101 153,421 2,369,442 SH   DFND 2 1,948,884 0 420,558
Appian Corp CL A 03782L101 14,345 221,540 SH   DFND 3 221,540 0 0
Appian Corp CL A 03782L101 62,594 966,697 SH   SOLE 0 966,697 0 0
Apple COM 037833100 22,867 197,453 SH   DFND 1 197,453 0 0
Apple COM 037833100 1,033 8,923 SH   DFND 2 0 0 8,923
Apple COM 037833100 35 302 SH   DFND 3 302 0 0
Apple COM 037833100 23,300 201,192 SH   SOLE 0 201,192 0 0
Ares Capital Corp COM 04010L103 24,845 1,781,000 SH   DFND 1 1,781,000 0 0
Ares Capital Corp COM 04010L103 49 3,500 SH   DFND 2 3,500 0 0
Ares Capital Corp COM 04010L103 1,344 96,370 SH   DFND 3 96,370 0 0
Atlassian Corp Plc CL A G06242104 113,596 624,877 SH   DFND 1 624,877 0 0
Atlassian Corp Plc CL A G06242104 754,891 4,152,543 SH   DFND 2 1,395,413 0 2,757,130
Atlassian Corp Plc CL A G06242104 54,956 302,306 SH   DFND 3 245,754 0 56,552
Atlassian Corp Plc CL A G06242104 257,925 1,418,805 SH   SOLE 0 716,220 0 702,585
Autohome Inc - ADR SP ADR RP CL A 05278C107 38,505 401,089 SH   DFND 1 401,089 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 134,927 1,405,490 SH   DFND 2 1,301,803 0 103,687
Autohome Inc - ADR SP ADR RP CL A 05278C107 29,711 309,490 SH   DFND 3 139,241 0 170,249
Autohome Inc - ADR SP ADR RP CL A 05278C107 96,040 1,000,420 SH   SOLE 0 927,223 0 73,197
Avangrid COM 05351W103 71,445 1,415,875 SH   DFND 1 1,415,875 0 0
Avangrid COM 05351W103 136 2,701 SH   DFND 2 2,701 0 0
Avangrid COM 05351W103 3,237 64,158 SH   DFND 3 64,158 0 0
Axogen Inc COM 05463X106 4,176 359,100 SH   DFND 1 359,100 0 0
Axogen Inc COM 05463X106 4,759 409,158 SH   DFND 2 154,583 0 254,575
Axogen Inc COM 05463X106 1,661 142,826 SH   DFND 3 142,826 0 0
Axogen Inc COM 05463X106 1,972 169,600 SH   SOLE 0 169,600 0 0
Axon Enterprise Inc COM 05464C101 69,393 765,084 SH   DFND 1 765,084 0 0
Axon Enterprise Inc COM 05464C101 167,769 1,849,708 SH   DFND 2 1,590,407 0 259,301
Axon Enterprise Inc COM 05464C101 39,808 438,899 SH   DFND 3 238,797 0 200,102
Axon Enterprise Inc COM 05464C101 113,744 1,254,064 SH   SOLE 0 1,169,694 0 84,370
Baidu.com Sponsored ADR SPON ADR REP A 056752108 15,411 121,736 SH   DFND 1 121,736 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 458,960 3,625,561 SH   DFND 2 3,459,705 0 165,856
Baidu.com Sponsored ADR SPON ADR REP A 056752108 23,402 184,865 SH   DFND 3 15,541 0 169,324
Baidu.com Sponsored ADR SPON ADR REP A 056752108 1,122 8,867 SH   DFND 4 8,867 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 840 6,639 SH   SOLE 0 6,639 0 0
BanColombia Pref ADR SPON ADR PREF 05968L102 6,570 257,155 SH   DFND 2 0 0 257,155
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 13,823 4,030,113 SH   DFND 1 4,030,113 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 93,247 27,185,764 SH   DFND 2 13,501,136 0 13,684,628
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 2,033 592,781 SH   DFND 3 592,781 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 17,275 531,708 SH   DFND 1 531,708 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 14,919 459,200 SH   DFND 2 169,005 0 290,195
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 5,228 160,921 SH   DFND 3 160,921 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 9,555 294,100 SH   SOLE 0 294,100 0 0
Barrick Gold Corp COM 067901108 168 6,005 SH   DFND 2 6,005 0 0
BeiGene Ltd SPONSORED ADR 07725L102 50,636 176,778 SH   DFND 1 176,778 0 0
BeiGene Ltd SPONSORED ADR 07725L102 276,305 964,619 SH   DFND 2 374,827 0 589,792
BeiGene Ltd SPONSORED ADR 07725L102 15,466 53,994 SH   DFND 3 44,448 0 9,546
BeiGene Ltd SPONSORED ADR 07725L102 68,688 239,798 SH   SOLE 0 121,854 0 117,944
Benefitfocus Inc COM 08180D106 3,432 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 3,472 309,982 SH   DFND 2 102,301 0 207,681
Benefitfocus Inc COM 08180D106 1,290 115,203 SH   DFND 3 115,203 0 0
Benefitfocus Inc COM 08180D106 2,535 226,368 SH   SOLE 0 226,368 0 0
Berkeley Lights Inc COM 084310101 25,794 337,794 SH   DFND 1 337,794 0 0
Berkeley Lights Inc COM 084310101 4,426 57,956 SH   DFND 2 45,876 0 12,080
Berkeley Lights Inc COM 084310101 6,108 79,986 SH   DFND 3 46,087 0 33,899
Berkeley Lights Inc COM 084310101 9,897 129,607 SH   SOLE 0 129,607 0 0
Beyond Meat Inc COM 08862E109 79,790 480,489 SH   DFND 1 480,489 0 0
Beyond Meat Inc COM 08862E109 291,349 1,754,483 SH   DFND 2 607,599 0 1,146,884
Beyond Meat Inc COM 08862E109 37,497 225,804 SH   DFND 3 155,820 0 69,984
Beyond Meat Inc COM 08862E109 97,199 585,327 SH   SOLE 0 297,308 0 288,019
Bilibili Inc ADR SPONSORED ADR 090040106 5,862 140,911 SH   DFND 1 140,911 0 0
BitAuto Holdings Ltd - ADR SPONSORED ADS 091727107 264 16,750 SH   SOLE 0 16,750 0 0
BlackRock Floating Rate Income COM 091941104 8,807 784,230 SH   DFND 1 784,230 0 0
Blackline COM 09239B109 48,556 541,742 SH   DFND 1 541,742 0 0
Blackline COM 09239B109 30,326 338,344 SH   DFND 2 124,457 0 213,887
Blackline COM 09239B109 10,693 119,306 SH   DFND 3 119,306 0 0
Blackline COM 09239B109 22,611 252,276 SH   SOLE 0 252,276 0 0
Blue Apron Holdings Inc CL A 09523Q101 1,063 148,506 SH   DFND 1 148,506 0 0
Bluebird Bio Inc COM 09609G100 470 8,714 SH   DFND 2 8,714 0 0
Bluebird Bio Inc COM 09609G100 181 3,354 SH   DFND 3 3,354 0 0
Bluebird Bio Inc COM 09609G100 37,495 695,000 SH   SOLE 0 695,000 0 0
Booking Holdings Inc COM 09857L108 77,827 45,495 SH   DFND 1 45,495 0 0
Booking Holdings Inc COM 09857L108 258,879 151,331 SH   DFND 2 134,739 0 16,592
Booking Holdings Inc COM 09857L108 55,874 32,662 SH   DFND 3 14,788 0 17,874
Booking Holdings Inc COM 09857L108 176,742 103,317 SH   SOLE 0 95,731 0 7,586
BridgeBio Pharma Inc COM 10806X102 1,617 43,096 SH   DFND 2 43,096 0 0
BridgeBio Pharma Inc COM 10806X102 652 17,373 SH   DFND 3 17,373 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 3,544 98,030 SH   DFND 1 98,030 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 141 3,912 SH   DFND 2 0 0 3,912
British Amer.Tobacco - ADR SPONSORED ADR 110448107 7 198 SH   DFND 3 198 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,194 116,021 SH   SOLE 0 116,021 0 0
Broadridge Finl.Sltn. COM 11133T103 70,989 537,792 SH   DFND 1 537,792 0 0
Broadridge Finl.Sltn. COM 11133T103 263,674 1,997,533 SH   DFND 2 1,860,894 0 136,639
Broadridge Finl.Sltn. COM 11133T103 51,534 390,411 SH   DFND 3 174,955 0 215,456
Broadridge Finl.Sltn. COM 11133T103 166,727 1,263,080 SH   SOLE 0 1,167,852 0 95,228
Brookfield Renewable COM 11284V105 41,067 700,805 SH   DFND 1 700,805 0 0
Brookfield Renewable COM 11284V105 121 2,071 SH   DFND 2 2,071 0 0
Brookfield Renewable COM 11284V105 3,007 51,307 SH   DFND 3 51,307 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 17,965 716,320 SH   DFND 1 716,320 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 4,649 185,352 SH   DFND 3 552 0 184,800
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 2,774 110,600 SH   SOLE 0 110,600 0 0
CEVA Inc COM 157210105 7,035 178,680 SH   DFND 1 178,680 0 0
CEVA Inc COM 157210105 6,554 166,479 SH   DFND 2 60,958 0 105,521
CEVA Inc COM 157210105 2,275 57,796 SH   DFND 3 57,796 0 0
CEVA Inc COM 157210105 3,248 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 27,510 269,209 SH   DFND 1 269,209 0 0
CH Robinson Worldwide COM NEW 12541W209 1,137 11,130 SH   DFND 2 0 0 11,130
CH Robinson Worldwide COM NEW 12541W209 42 411 SH   DFND 3 411 0 0
CH Robinson Worldwide COM NEW 12541W209 28,625 280,119 SH   SOLE 0 280,119 0 0
Carvana COM 146869102 246,582 1,105,451 SH   DFND 1 1,105,451 0 0
Carvana COM 146869102 639,938 2,868,905 SH   DFND 2 1,471,968 0 1,396,937
Carvana COM 146869102 38,974 174,723 SH   DFND 3 145,239 0 29,484
Carvana COM 146869102 344,112 1,542,687 SH   SOLE 0 1,195,929 0 346,758
Cbre Group Inc CL A 12504L109 33,448 712,114 SH   DFND 1 712,114 0 0
Cbre Group Inc CL A 12504L109 136,337 2,902,631 SH   DFND 2 2,636,101 0 266,530
Cbre Group Inc CL A 12504L109 24,211 515,453 SH   DFND 3 233,309 0 282,144
Cbre Group Inc CL A 12504L109 78,248 1,665,918 SH   SOLE 0 1,540,375 0 125,543
Cemex ADR SPON ADR NEW 151290889 17,876 4,704,115 SH   DFND 1 4,704,115 0 0
Cemex ADR SPON ADR NEW 151290889 96,037 25,272,989 SH   DFND 2 9,866,775 0 15,406,214
Cemex ADR SPON ADR NEW 151290889 32,968 8,675,731 SH   DFND 3 500,299 0 8,175,432
Cemex ADR SPON ADR NEW 151290889 1,656 435,758 SH   DFND 4 435,758 0 0
Chegg COM 163092109 368,717 5,161,217 SH   DFND 1 5,161,217 0 0
Chegg COM 163092109 460,809 6,450,295 SH   DFND 2 5,553,504 0 896,791
Chegg COM 163092109 75,586 1,058,034 SH   DFND 3 722,485 0 335,549
Chegg COM 163092109 219,101 3,066,917 SH   SOLE 0 2,951,252 0 115,665
Chewy Inc CL A 16679L109 149,805 2,732,170 SH   DFND 1 2,732,170 0 0
Chewy Inc CL A 16679L109 163,950 2,990,154 SH   DFND 2 2,808,254 0 181,900
Chewy Inc CL A 16679L109 4,404 80,314 SH   DFND 3 80,314 0 0
Chewy Inc CL A 16679L109 36,524 666,134 SH   SOLE 0 666,134 0 0
Chinook Therapeutics COM 16961L106 4,814 1,980,937 SH   DFND 1 1,980,937 0 0
Chinook Therapeutics COM 16961L106 2,999 1,234,263 SH   DFND 2 503,945 0 730,318
Chinook Therapeutics COM 16961L106 1,131 465,487 SH   DFND 3 465,487 0 0
Chinook Therapeutics COM 16961L106 1,422 585,293 SH   SOLE 0 585,293 0 0
Cisco Systems COM 17275R102 11,851 300,863 SH   DFND 1 300,863 0 0
Cisco Systems COM 17275R102 395 10,026 SH   DFND 2 0 0 10,026
Cisco Systems COM 17275R102 18 459 SH   DFND 3 459 0 0
Cisco Systems COM 17275R102 11,830 300,321 SH   SOLE 0 300,321 0 0
Cloudera Inc COM 18914U100 24,549 2,254,228 SH   DFND 1 2,254,228 0 0
Cloudera Inc COM 18914U100 18,285 1,679,082 SH   DFND 2 617,761 0 1,061,321
Cloudera Inc COM 18914U100 6,490 595,950 SH   DFND 3 595,950 0 0
Cloudera Inc COM 18914U100 12,555 1,152,890 SH   SOLE 0 1,152,890 0 0
Cloudflare Inc CL A COM 18915M107 202,038 4,920,550 SH   DFND 1 4,920,550 0 0
Cloudflare Inc CL A COM 18915M107 612,532 14,917,984 SH   DFND 2 8,458,608 0 6,459,376
Cloudflare Inc CL A COM 18915M107 63,387 1,543,763 SH   DFND 3 967,832 0 575,931
Cloudflare Inc CL A COM 18915M107 257,458 6,270,279 SH   SOLE 0 4,585,224 0 1,685,055
CoStar Group COM 22160N109 162,787 191,850 SH   DFND 1 191,850 0 0
CoStar Group COM 22160N109 176,642 208,179 SH   DFND 2 196,480 0 11,699
CoStar Group COM 22160N109 4,920 5,798 SH   DFND 3 5,798 0 0
CoStar Group COM 22160N109 40,474 47,700 SH   SOLE 0 47,700 0 0
Coca Cola COM 191216100 29,811 603,837 SH   DFND 1 603,837 0 0
Coca Cola COM 191216100 1,179 23,883 SH   DFND 2 0 0 23,883
Coca Cola COM 191216100 45 920 SH   DFND 3 920 0 0
Coca Cola COM 191216100 30,634 620,502 SH   SOLE 0 620,502 0 0
Codexis COM 192005106 20,392 1,737,008 SH   DFND 1 1,737,008 0 0
Codexis COM 192005106 21,399 1,822,736 SH   DFND 2 668,119 0 1,154,617
Codexis COM 192005106 7,509 639,576 SH   DFND 3 639,576 0 0
Codexis COM 192005106 13,641 1,161,941 SH   SOLE 0 1,161,941 0 0
Consolidated Edison COM 209115104 56,766 729,640 SH   DFND 1 729,640 0 0
Consolidated Edison COM 209115104 99 1,275 SH   DFND 2 1,275 0 0
Consolidated Edison COM 209115104 2,385 30,661 SH   DFND 3 30,661 0 0
Copa Holdings S A CL A P31076105 18,638 370,234 SH   DFND 1 370,234 0 0
Copa Holdings S A CL A P31076105 175,020 3,476,752 SH   DFND 2 2,220,254 0 1,256,498
Copa Holdings S A CL A P31076105 37,046 735,917 SH   DFND 3 38,888 0 697,029
Copa Holdings S A CL A P31076105 1,756 34,873 SH   DFND 4 34,873 0 0
Copa Holdings S A CL A P31076105 13,986 277,829 SH   SOLE 0 277,829 0 0
Credicorp COM G2519Y108 12,808 103,298 SH   DFND 1 103,298 0 0
Credicorp COM G2519Y108 182,644 1,473,053 SH   DFND 2 848,808 0 624,245
Credicorp COM G2519Y108 25,172 203,017 SH   DFND 3 11,583 0 191,434
Credicorp COM G2519Y108 1,251 10,091 SH   DFND 4 10,091 0 0
Credicorp COM G2519Y108 15,071 121,553 SH   SOLE 0 121,553 0 0
Cullen/Frost Bankers COM 229899109 6,650 103,992 SH   DFND 1 103,992 0 0
Cullen/Frost Bankers COM 229899109 323 5,045 SH   DFND 2 0 0 5,045
Cullen/Frost Bankers COM 229899109 11 169 SH   DFND 3 169 0 0
Cullen/Frost Bankers COM 229899109 7,730 120,878 SH   SOLE 0 120,878 0 0
CureVac N.V. - Converted at IPO COM N2451R105 87,049 1,870,009 SH   DFND 2 1,870,009 0 0
CureVac N.V. - Converted at IPO COM N2451R105 72,541 1,558,341 SH   SOLE 0 1,558,341 0 0
Curevac N.V. COM N2451R105 11,886 255,341 SH   DFND 2 255,341 0 0
Curevac N.V. COM N2451R105 9,905 212,784 SH   SOLE 0 212,784 0 0
CyberArk Software Ltd SHS M2682V108 23,153 223,877 SH   DFND 1 223,877 0 0
CyberArk Software Ltd SHS M2682V108 23,218 224,502 SH   DFND 2 82,607 0 141,895
CyberArk Software Ltd SHS M2682V108 8,196 79,246 SH   DFND 3 79,246 0 0
CyberArk Software Ltd SHS M2682V108 11,906 115,118 SH   SOLE 0 115,118 0 0
DTE Energy Co COM 233331107 52,217 453,900 SH   DFND 1 453,900 0 0
DTE Energy Co COM 233331107 96 838 SH   DFND 2 838 0 0
DTE Energy Co COM 233331107 2,622 22,796 SH   DFND 3 22,796 0 0
Dada Nexus Ltd ADR ADS 23344D108 15,233 575,493 SH   DFND 1 575,493 0 0
Dada Nexus Ltd ADR ADS 23344D108 19 722 SH   DFND 3 722 0 0
Dada Nexus Ltd ADR ADS 23344D108 4,063 153,479 SH   SOLE 0 153,479 0 0
Datadog COM 23804L103 135,840 1,329,683 SH   DFND 1 1,329,683 0 0
Datadog COM 23804L103 257,341 2,518,998 SH   DFND 2 2,287,015 0 231,983
Datadog COM 23804L103 37,622 368,264 SH   DFND 3 181,681 0 186,583
Datadog COM 23804L103 136,896 1,340,012 SH   SOLE 0 1,259,574 0 80,438
Deere & Co COM 244199105 31,931 144,073 SH   DFND 1 144,073 0 0
Deere & Co COM 244199105 7,600 34,290 SH   DFND 2 22,707 0 11,583
Deere & Co COM 244199105 14,860 67,050 SH   DFND 3 35,401 0 31,649
Denali Therapeutics COM 24823R105 79,050 2,206,253 SH   DFND 1 2,206,253 0 0
Denali Therapeutics COM 24823R105 81,650 2,278,827 SH   DFND 2 2,142,204 0 136,623
Denali Therapeutics COM 24823R105 5,847 163,183 SH   DFND 3 129,674 0 33,509
Denali Therapeutics COM 24823R105 221,391 6,178,915 SH   SOLE 0 6,178,915 0 0
Dexcom Inc COM 252131107 240,523 583,467 SH   DFND 1 583,467 0 0
Dexcom Inc COM 252131107 1,035,086 2,510,942 SH   DFND 2 859,629 0 1,651,313
Dexcom Inc COM 252131107 114,184 276,992 SH   DFND 3 203,627 0 73,365
Dexcom Inc COM 252131107 353,304 857,055 SH   SOLE 0 446,095 0 410,960
Digimarc COM 25381B101 4,157 186,145 SH   DFND 1 186,145 0 0
Digimarc COM 25381B101 6,915 309,685 SH   DFND 2 114,812 0 194,873
Digimarc COM 25381B101 2,475 110,857 SH   DFND 3 110,857 0 0
Digimarc COM 25381B101 3,455 154,711 SH   SOLE 0 154,711 0 0
Dolby Laboratories 'A' COM 25659T107 9,443 142,467 SH   DFND 1 142,467 0 0
Dolby Laboratories 'A' COM 25659T107 388 5,858 SH   DFND 2 0 0 5,858
Dolby Laboratories 'A' COM 25659T107 14 213 SH   DFND 3 213 0 0
Dolby Laboratories 'A' COM 25659T107 9,365 141,302 SH   SOLE 0 141,302 0 0
EOG Resources COM 26875P101 35,814 996,503 SH   DFND 1 996,503 0 0
EOG Resources COM 26875P101 127,426 3,545,520 SH   DFND 2 3,295,220 0 250,300
EOG Resources COM 26875P101 17,789 494,969 SH   DFND 3 253,391 0 241,578
EOG Resources COM 26875P101 82,201 2,287,167 SH   SOLE 0 2,116,663 0 170,504
Ecolab COM 278865100 25,276 126,479 SH   DFND 1 126,479 0 0
Ecolab COM 278865100 6,017 30,108 SH   DFND 2 19,902 0 10,206
Ecolab COM 278865100 11,704 58,565 SH   DFND 3 31,211 0 27,354
Edwards Lifesciences Corp COM 28176E108 18,727 234,619 SH   DFND 2 234,619 0 0
Edwards Lifesciences Corp COM 28176E108 1,506 18,862 SH   DFND 3 18,862 0 0
Estee Lauder 'A' COM 518439104 88,577 405,849 SH   DFND 1 405,849 0 0
Estee Lauder 'A' COM 518439104 331,985 1,521,124 SH   DFND 2 1,421,338 0 99,786
Estee Lauder 'A' COM 518439104 63,624 291,520 SH   DFND 3 131,905 0 159,615
Estee Lauder 'A' COM 518439104 201,183 921,800 SH   SOLE 0 854,122 0 67,678
Eventbrite Inc Class A COM CL A 29975E109 15,050 1,387,142 SH   DFND 1 1,387,142 0 0
Eventbrite Inc Class A COM CL A 29975E109 17,329 1,597,098 SH   DFND 2 1,508,511 0 88,587
Eventbrite Inc Class A COM CL A 29975E109 461 42,444 SH   DFND 3 42,444 0 0
Eventbrite Inc Class A COM CL A 29975E109 3,761 346,666 SH   SOLE 0 346,666 0 0
EverQuote Inc COM CL A 30041R108 19,732 510,667 SH   DFND 1 510,667 0 0
EverQuote Inc COM CL A 30041R108 11,313 292,774 SH   DFND 2 107,652 0 185,122
EverQuote Inc COM CL A 30041R108 3,918 101,407 SH   DFND 3 101,407 0 0
EverQuote Inc COM CL A 30041R108 7,239 187,350 SH   SOLE 0 187,350 0 0
Eversource Energy COM 30040W108 44,629 534,156 SH   DFND 1 534,156 0 0
Eversource Energy COM 30040W108 90 1,077 SH   DFND 2 1,077 0 0
Eversource Energy COM 30040W108 2,202 26,353 SH   DFND 3 26,353 0 0
Exact Sciences COM 30063P105 28,972 284,181 SH   DFND 1 284,181 0 0
Exact Sciences COM 30063P105 40,282 395,118 SH   DFND 2 163,008 0 232,110
Exact Sciences COM 30063P105 16,278 159,665 SH   DFND 3 151,519 0 8,146
Exact Sciences COM 30063P105 17,302 169,715 SH   SOLE 0 169,715 0 0
Exelon Corporation COM 30161N101 693 19,387 SH   DFND 1 19,387 0 0
Facebook Cl.A CL A 30303M102 308,376 1,177,458 SH   DFND 1 1,177,458 0 0
Facebook Cl.A CL A 30303M102 1,731,459 6,611,144 SH   DFND 2 3,023,777 0 3,587,367
Facebook Cl.A CL A 30303M102 176,462 673,775 SH   DFND 3 449,902 0 223,873
Facebook Cl.A CL A 30303M102 711,623 2,717,157 SH   SOLE 0 1,760,284 0 956,873
Farfetch ORD SHS CL A 30744W107 49,040 1,949,145 SH   DFND 1 1,949,145 0 0
Farfetch ORD SHS CL A 30744W107 150,560 5,984,100 SH   DFND 2 5,543,883 0 440,217
Farfetch ORD SHS CL A 30744W107 35,162 1,397,539 SH   DFND 3 702,903 0 694,636
Farfetch ORD SHS CL A 30744W107 133,877 5,321,007 SH   SOLE 0 4,551,718 0 769,289
Faro Technologies COM 311642102 6,203 101,715 SH   DFND 1 101,715 0 0
Faro Technologies COM 311642102 10,538 172,803 SH   DFND 2 63,836 0 108,967
Faro Technologies COM 311642102 3,729 61,157 SH   DFND 3 61,157 0 0
Faro Technologies COM 311642102 6,579 107,880 SH   SOLE 0 107,880 0 0
Fastenal COM 311900104 39,544 877,004 SH   DFND 1 877,004 0 0
Fastenal COM 311900104 20,580 456,416 SH   DFND 2 425,362 0 31,054
Fastenal COM 311900104 4,115 91,254 SH   DFND 3 58,586 0 32,668
Fastenal COM 311900104 36,809 816,350 SH   SOLE 0 816,350 0 0
Ferrari NV COM N3167Y103 367,942 2,003,000 SH   SOLE 0 2,003,000 0 0
Ferrari NV COM N3167Y103 1,849,011 10,065,622 SH   DFND 2 7,907,914 0 2,157,708
Fiat Chrysler Automobiles SHS N31738102 375,848 30,618,275 SH   DFND 2 22,516,503 0 8,101,772
First Quantum Minerals COM 335934105 16,643 1,872,833 SH   DFND 1 1,872,833 0 0
First Quantum Minerals COM 335934105 77,433 8,713,635 SH   DFND 2 6,456,557 0 2,257,078
First Republic Bank COM 33616C100 177,092 1,623,801 SH   DFND 1 1,623,801 0 0
First Republic Bank COM 33616C100 217,565 1,994,907 SH   DFND 2 1,893,768 0 101,139
First Republic Bank COM 33616C100 11,128 102,038 SH   DFND 3 82,054 0 19,984
First Republic Bank COM 33616C100 46,780 428,934 SH   SOLE 0 428,934 0 0
Fortis COM 349553107 768 18,837 SH   DFND 1 18,837 0 0
Fortive Corp COM 34959J108 11,099 145,632 SH   DFND 2 145,632 0 0
Glaukos Corp COM 377322102 99,905 2,017,471 SH   DFND 1 2,017,471 0 0
Glaukos Corp COM 377322102 82,758 1,671,212 SH   DFND 2 1,545,238 0 125,974
Glaukos Corp COM 377322102 13,988 282,477 SH   DFND 3 178,378 0 104,099
Glaukos Corp COM 377322102 20,488 413,736 SH   SOLE 0 413,736 0 0
Grifols ADR SP ADR REP B NVT 398438408 50,438 2,907,108 SH   DFND 2 2,082,160 0 824,948
Grifols ADR SP ADR REP B NVT 398438408 6,705 386,447 SH   SOLE 0 386,447 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 35,969 719,959 SH   DFND 2 620,854 0 99,105
HDFC Bank ADR ADR REPS 3 SHS 40415F101 8,839 176,914 SH   DFND 3 79,459 0 97,455
HDFC Bank ADR ADR REPS 3 SHS 40415F101 60,423 1,209,421 SH   SOLE 0 1,092,867 0 116,554
HEICO COM 422806109 9,994 95,493 SH   DFND 1 95,493 0 0
HEICO COM 422806109 7,049 67,355 SH   SOLE 0 67,355 0 0
HEICO 'A' CL A 422806208 44,859 505,971 SH   DFND 1 505,971 0 0
HEICO 'A' CL A 422806208 68,346 770,877 SH   DFND 2 734,398 0 36,479
HEICO 'A' CL A 422806208 1,594 17,982 SH   DFND 3 17,982 0 0
HEICO 'A' CL A 422806208 6,774 76,399 SH   SOLE 0 76,399 0 0
HUYA ADR ADS REP SHS A 44852D108 31,098 1,298,454 SH   DFND 1 1,298,454 0 0
HUYA ADR ADS REP SHS A 44852D108 9,237 385,672 SH   DFND 3 908 0 384,764
HUYA ADR ADS REP SHS A 44852D108 11,791 492,323 SH   SOLE 0 492,323 0 0
Health Catalyst Inc COM 42225T107 1,626 44,427 SH   DFND 2 44,427 0 0
Health Catalyst Inc COM 42225T107 655 17,888 SH   DFND 3 17,888 0 0
Howard Hughes COM 44267D107 25,494 442,608 SH   DFND 1 442,608 0 0
Howard Hughes COM 44267D107 88,180 1,530,906 SH   DFND 2 1,419,810 0 111,096
Howard Hughes COM 44267D107 19,107 331,715 SH   DFND 3 147,181 0 184,534
Howard Hughes COM 44267D107 61,576 1,069,028 SH   SOLE 0 992,101 0 76,927
Hutchison China Meditech SPONSORED ADR 44842L103 2,599 80,461 SH   DFND 1 80,461 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 6,174 191,146 SH   DFND 3 0 0 191,146
ICICI Bank ADR ADR 45104G104 73,017 7,427,969 SH   DFND 1 7,427,969 0 0
ICICI Bank ADR ADR 45104G104 65,200 6,632,718 SH   DFND 2 5,914,591 0 718,127
ICICI Bank ADR ADR 45104G104 37,105 3,774,629 SH   DFND 3 1,859,944 0 1,914,685
ICICI Bank ADR ADR 45104G104 5,306 539,749 SH   DFND 4 539,749 0 0
ICICI Bank ADR ADR 45104G104 87,643 8,915,885 SH   SOLE 0 8,355,531 0 560,354
IPG Photonics Corp COM 44980X109 18,501 108,847 SH   DFND 1 108,847 0 0
IPG Photonics Corp COM 44980X109 19,112 112,443 SH   DFND 2 41,556 0 70,887
IPG Photonics Corp COM 44980X109 6,764 39,794 SH   DFND 3 39,794 0 0
IPG Photonics Corp COM 44980X109 12,516 73,636 SH   SOLE 0 73,636 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 17,607 2,639,774 SH   DFND 1 2,639,774 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 23 3,522 SH   DFND 3 3,522 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 4,612 691,490 SH   SOLE 0 691,490 0 0
Illumina COM 452327109 541,253 1,751,173 SH   DFND 1 1,751,173 0 0
Illumina COM 452327109 3,174,835 10,271,886 SH   DFND 2 6,795,950 0 3,475,936
Illumina COM 452327109 194,334 628,751 SH   DFND 3 437,027 0 191,724
Illumina COM 452327109 1,568,201 5,073,770 SH   SOLE 0 4,234,696 0 839,074
Infosys Ltd ADR SPONSORED ADR 456788108 12,743 922,731 SH   DFND 1 922,731 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 12,136 878,777 SH   DFND 2 208,166 0 670,611
Infosys Ltd ADR SPONSORED ADR 456788108 4,665 337,773 SH   DFND 3 215,356 0 122,417
Infosys Ltd ADR SPONSORED ADR 456788108 2,630 190,455 SH   DFND 4 190,455 0 0
Interactive Brokers Group COM 45841N107 47,903 991,163 SH   DFND 1 991,163 0 0
Interactive Brokers Group COM 45841N107 118,388 2,449,574 SH   DFND 2 2,296,380 0 153,194
Interactive Brokers Group COM 45841N107 23,379 483,734 SH   DFND 3 236,154 0 247,580
Interactive Brokers Group COM 45841N107 68,072 1,408,493 SH   SOLE 0 1,313,034 0 95,459
Intuitive Surgical COM NEW 46120E602 112,858 159,058 SH   DFND 1 159,058 0 0
Intuitive Surgical COM NEW 46120E602 739,646 1,042,430 SH   DFND 2 350,438 0 691,992
Intuitive Surgical COM NEW 46120E602 54,078 76,215 SH   DFND 3 61,959 0 14,256
Intuitive Surgical COM NEW 46120E602 425,269 599,359 SH   SOLE 0 423,429 0 175,930
Invesco Senior Income Trust COM 46131H107 9,358 2,556,949 SH   DFND 1 2,556,949 0 0
Invesco Senior Income Trust COM 46131H107 2,338 638,746 SH   DFND 3 638,746 0 0
Ionis Pharmaceuticals COM 462222100 22,723 478,891 SH   DFND 1 478,891 0 0
Ionis Pharmaceuticals COM 462222100 149,065 3,141,525 SH   DFND 2 1,093,830 0 2,047,695
Ionis Pharmaceuticals COM 462222100 11,123 234,417 SH   DFND 3 191,971 0 42,446
Ionis Pharmaceuticals COM 462222100 50,582 1,066,010 SH   SOLE 0 544,530 0 521,480
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 9,454 2,375,333 SH   DFND 1 2,375,333 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 92,050 23,128,033 SH   DFND 2 12,242,642 0 10,885,391
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 36,591 9,193,641 SH   DFND 3 549,856 0 8,643,785
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 1,963 493,153 SH   DFND 4 493,153 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 8,352 2,098,498 SH   SOLE 0 2,098,498 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 91,558 1,179,721 SH   DFND 1 1,179,721 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 19,394 249,893 SH   DFND 2 105,677 0 144,216
JD.Com Inc - ADR SPON ADR CL A 47215P106 64,234 827,647 SH   DFND 3 1,581 0 826,066
JD.Com Inc - ADR SPON ADR CL A 47215P106 22,657 291,937 SH   SOLE 0 291,937 0 0
Jefferies Financial Group Inc COM 47233W109 31,185 1,732,474 SH   DFND 1 1,732,474 0 0
Jefferies Financial Group Inc COM 47233W109 101,084 5,615,750 SH   DFND 2 5,196,077 0 419,673
Jefferies Financial Group Inc COM 47233W109 21,613 1,200,735 SH   DFND 3 555,439 0 645,296
Jefferies Financial Group Inc COM 47233W109 72,572 4,031,757 SH   SOLE 0 3,733,519 0 298,238
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 72,050 9,017,500 SH   DFND 2 8,893,268 0 124,232
KE Holdings ADR ADR 482497104 118,740 1,937,039 SH   DFND 1 1,937,039 0 0
KE Holdings ADR ADR 482497104 502,708 8,200,780 SH   DFND 2 4,421,600 0 3,779,180
KE Holdings ADR ADR 482497104 28,360 462,646 SH   DFND 3 273,000 0 189,646
KE Holdings ADR ADR 482497104 253,124 4,129,265 SH   SOLE 0 3,518,759 0 610,506
Kaleido Biosciences Inc COM 483347100 2,729 246,500 SH   DFND 1 246,500 0 0
Kaleido Biosciences Inc COM 483347100 2,142 193,500 SH   SOLE 0 193,500 0 0
Kirby COM 497266106 15,814 437,211 SH   DFND 1 437,211 0 0
Kirby COM 497266106 52,646 1,455,523 SH   DFND 2 1,346,109 0 109,414
Kirby COM 497266106 11,150 308,280 SH   DFND 3 140,975 0 167,305
Kirby COM 497266106 35,878 991,927 SH   SOLE 0 919,794 0 72,133
Korea Electric Power ADR SPONSORED ADR 500631106 17 1,900 SH   DFND 2 1,900 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 1,325 152,080 SH   DFND 3 152,080 0 0
Lemonade Inc COM 52567D107 57,693 1,160,362 SH   DFND 1 1,160,362 0 0
Lemonade Inc COM 52567D107 59,429 1,195,270 SH   DFND 2 1,122,542 0 72,728
Lemonade Inc COM 52567D107 1,669 33,571 SH   DFND 3 33,571 0 0
Lemonade Inc COM 52567D107 38,651 777,382 SH   SOLE 0 777,382 0 0
LendingTree COM 52603B107 79,830 260,127 SH   DFND 1 260,127 0 0
LendingTree COM 52603B107 178,066 580,228 SH   DFND 2 420,259 0 159,969
LendingTree COM 52603B107 51,649 168,299 SH   DFND 3 120,542 0 47,757
LendingTree COM 52603B107 109,569 357,029 SH   SOLE 0 339,730 0 17,299
Lindblad Expeditions Holdings COM 535219109 5,957 700,000 SH   SOLE 0 700,000 0 0
LivePerson Inc COM 538146101 21,347 410,591 SH   DFND 1 410,591 0 0
LivePerson Inc COM 538146101 19,212 369,530 SH   DFND 2 134,180 0 235,350
LivePerson Inc COM 538146101 6,622 127,371 SH   DFND 3 127,371 0 0
LivePerson Inc COM 538146101 12,887 247,880 SH   SOLE 0 247,880 0 0
Liveramp Holdings Inc COM 53815P108 26,413 510,201 SH   DFND 1 510,201 0 0
Liveramp Holdings Inc COM 53815P108 16,327 315,385 SH   DFND 2 115,798 0 199,587
Liveramp Holdings Inc COM 53815P108 5,564 107,476 SH   DFND 3 107,476 0 0
Liveramp Holdings Inc COM 53815P108 13,568 262,075 SH   SOLE 0 262,075 0 0
Livongo Health Inc COM 539183103 1,648 11,770 SH   DFND 2 11,770 0 0
Livongo Health Inc COM 539183103 668 4,772 SH   DFND 3 4,772 0 0
Lyft Inc Class A Common CL A COM 55087P104 48,356 1,755,225 SH   DFND 1 1,755,225 0 0
Lyft Inc Class A Common CL A COM 55087P104 119,598 4,341,133 SH   DFND 2 4,042,045 0 299,088
Lyft Inc Class A Common CL A COM 55087P104 22,164 804,491 SH   DFND 3 384,130 0 420,361
Lyft Inc Class A Common CL A COM 55087P104 113,969 4,136,813 SH   SOLE 0 3,963,628 0 173,185
M&T Bank COM 55261F104 7,789 84,580 SH   DFND 2 84,580 0 0
MRC Global COM 55345K103 2,782 650,000 SH   SOLE 0 650,000 0 0
MakeMyTrip SHS V5633W109 41,173 2,680,559 SH   DFND 2 2,009,654 0 670,905
Markel Corp COM 570535104 58,976 60,569 SH   DFND 1 60,569 0 0
Markel Corp COM 570535104 198,129 203,481 SH   DFND 2 189,393 0 14,088
Markel Corp COM 570535104 42,301 43,444 SH   DFND 3 20,334 0 23,110
Markel Corp COM 570535104 131,186 134,729 SH   SOLE 0 124,885 0 9,844
MarketAxess Holdings COM 57060D108 267,072 554,564 SH   DFND 1 554,564 0 0
MarketAxess Holdings COM 57060D108 331,119 687,554 SH   DFND 2 547,207 0 140,347
MarketAxess Holdings COM 57060D108 50,314 104,474 SH   DFND 3 93,780 0 10,694
MarketAxess Holdings COM 57060D108 111,228 230,960 SH   SOLE 0 230,960 0 0
Martin Marietta Materials COM 573284106 83,250 353,715 SH   DFND 1 353,715 0 0
Martin Marietta Materials COM 573284106 288,617 1,226,277 SH   DFND 2 1,138,280 0 87,997
Martin Marietta Materials COM 573284106 60,786 258,267 SH   DFND 3 116,450 0 141,817
Martin Marietta Materials COM 573284106 200,225 850,717 SH   SOLE 0 790,833 0 59,884
Masimo Corp COM 574795100 2,294 9,718 SH   DFND 2 9,718 0 0
Masimo Corp COM 574795100 925 3,918 SH   DFND 3 3,918 0 0
Mastercard Inc-Class A CL A 57636Q104 432,085 1,277,714 SH   DFND 1 1,277,714 0 0
Mastercard Inc-Class A CL A 57636Q104 924,749 2,734,567 SH   DFND 2 2,554,880 0 179,687
Mastercard Inc-Class A CL A 57636Q104 147,658 436,638 SH   DFND 3 212,341 0 224,297
Mastercard Inc-Class A CL A 57636Q104 485,531 1,435,761 SH   SOLE 0 1,342,339 0 93,422
McDonald's COM 580135101 18,760 85,470 SH   DFND 1 85,470 0 0
McDonald's COM 580135101 810 3,689 SH   DFND 2 0 0 3,689
McDonald's COM 580135101 29 132 SH   DFND 3 132 0 0
McDonald's COM 580135101 19,291 87,890 SH   SOLE 0 87,890 0 0
Medtronic COM G5960L903 10,381 99,896 SH   DFND 1 99,896 0 0
Medtronic COM G5960L903 362 3,481 SH   DFND 2 0 0 3,481
Medtronic COM G5960L903 16 156 SH   DFND 3 156 0 0
Medtronic COM G5960L903 10,948 105,354 SH   SOLE 0 105,354 0 0
MercadoLibre COM 58733R102 236,974 218,918 SH   DFND 1 218,918 0 0
MercadoLibre COM 58733R102 4,542,463 4,196,348 SH   DFND 2 3,402,514 0 793,834
MercadoLibre COM 58733R102 54,383 50,239 SH   DFND 3 37,403 0 12,836
MercadoLibre COM 58733R102 10,262 9,480 SH   DFND 4 9,480 0 0
MercadoLibre COM 58733R102 418,233 386,366 SH   SOLE 0 386,366 0 0
Mettler-Toledo COM 592688105 73,163 75,758 SH   DFND 1 75,758 0 0
Mettler-Toledo COM 592688105 480,682 497,729 SH   DFND 2 354,271 0 143,458
Mettler-Toledo COM 592688105 2,379 2,463 SH   DFND 3 2,463 0 0
Mettler-Toledo COM 592688105 28,998 30,026 SH   SOLE 0 30,026 0 0
Microsoft COM 594918104 212,292 1,009,327 SH   DFND 1 1,009,327 0 0
Microsoft COM 594918104 683,827 3,251,208 SH   DFND 2 3,031,062 0 220,146
Microsoft COM 594918104 131,926 627,232 SH   DFND 3 285,269 0 341,963
Microsoft COM 594918104 448,546 2,132,580 SH   SOLE 0 1,984,551 0 148,029
Mobile Telesystems ADR SPONSORED ADR 607409109 259 29,700 SH   DFND 1 29,700 0 0
Moderna Inc COM 60770K107 174,826 2,471,032 SH   DFND 1 2,471,032 0 0
Moderna Inc COM 60770K107 232,260 3,282,825 SH   DFND 2 2,048,714 0 1,234,111
Moderna Inc COM 60770K107 39,172 553,667 SH   DFND 3 361,209 0 192,458
Moderna Inc COM 60770K107 64,956 918,112 SH   SOLE 0 643,529 0 274,583
Moody's Corp COM 615369105 213,496 736,575 SH   DFND 1 736,575 0 0
Moody's Corp COM 615369105 746,755 2,576,349 SH   DFND 2 2,392,447 0 183,902
Moody's Corp COM 615369105 155,588 536,788 SH   DFND 3 243,834 0 292,954
Moody's Corp COM 615369105 488,240 1,684,457 SH   SOLE 0 1,558,383 0 126,074
Myokardia Inc COM 62857M105 2,041 14,970 SH   DFND 2 14,970 0 0
Myokardia Inc COM 62857M105 821 6,023 SH   DFND 3 6,023 0 0
NIO Inc ADR SPON ADS 62914V106 87,469 4,121,997 SH   DFND 1 4,121,997 0 0
NIO Inc ADR SPON ADS 62914V106 1,513,183 71,309,275 SH   DFND 2 50,109,992 0 21,199,283
NIO Inc ADR SPON ADS 62914V106 39,814 1,876,251 SH   DFND 3 1,507,207 0 369,044
NIO Inc ADR SPON ADS 62914V106 671,169 31,629,063 SH   SOLE 0 27,107,585 0 4,521,478
NVIDIA COM 67066G104 300,282 554,825 SH   DFND 1 554,825 0 0
NVIDIA COM 67066G104 1,261,339 2,330,548 SH   DFND 2 1,004,887 0 1,325,661
NVIDIA COM 67066G104 83,373 154,046 SH   DFND 3 123,084 0 30,962
NVIDIA COM 67066G104 854,570 1,578,970 SH   SOLE 0 1,261,835 0 317,135
National Instruments Corp COM 636518102 12,740 356,852 SH   DFND 1 356,852 0 0
National Instruments Corp COM 636518102 6,054 169,593 SH   DFND 2 58,606 0 110,987
National Instruments Corp COM 636518102 1,998 55,965 SH   DFND 3 55,965 0 0
National Instruments Corp COM 636518102 13,196 369,640 SH   SOLE 0 369,640 0 0
NetEase.com ADR SPONSORED ADR 64110W102 94,132 207,034 SH   DFND 1 207,034 0 0
NetEase.com ADR SPONSORED ADR 64110W102 492,372 1,082,921 SH   DFND 2 319,668 0 763,253
NetEase.com ADR SPONSORED ADR 64110W102 39,374 86,600 SH   DFND 3 70,469 0 16,131
NetEase.com ADR SPONSORED ADR 64110W102 183,493 403,573 SH   SOLE 0 205,219 0 198,354
Netflix Inc COM 64110L106 622,483 1,244,892 SH   DFND 1 1,244,892 0 0
Netflix Inc COM 64110L106 1,813,376 3,626,534 SH   DFND 2 1,935,808 0 1,690,726
Netflix Inc COM 64110L106 155,224 310,430 SH   DFND 3 222,893 0 87,537
Netflix Inc COM 64110L106 1,114,711 2,229,288 SH   SOLE 0 1,795,784 0 433,504
Newmont Mining COM 651639106 203 3,200 SH   DFND 2 3,200 0 0
NextEra Energy COM 65339F101 837 3,014 SH   DFND 1 3,014 0 0
Novocure Ltd ORD SHS G6674U108 266,688 2,395,900 SH   DFND 1 2,395,900 0 0
Novocure Ltd ORD SHS G6674U108 388,011 3,485,855 SH   DFND 2 3,010,107 0 475,748
Novocure Ltd ORD SHS G6674U108 59,582 535,277 SH   DFND 3 354,886 0 180,391
Novocure Ltd ORD SHS G6674U108 190,074 1,707,613 SH   SOLE 0 1,630,982 0 76,631
Now Inc/DE COM 67011P100 55 12,154 SH   DFND 1 12,154 0 0
Now Inc/DE COM 67011P100 199 43,762 SH   DFND 2 40,322 0 3,440
Now Inc/DE COM 67011P100 38 8,471 SH   DFND 3 4,155 0 4,316
Now Inc/DE COM 67011P100 162 35,613 SH   SOLE 0 33,438 0 2,175
Nucana Plc ADR SPONSORED ADR 67022C106 9,360 1,810,541 SH   DFND 1 1,810,541 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 6,406 1,238,989 SH   SOLE 0 1,238,989 0 0
Nuveen Senior Income Fund COM 67067Y104 1,811 375,012 SH   DFND 1 375,012 0 0
Orchard Therapeutics PLC ADR ADS 68570P101 11,261 2,740,000 SH   SOLE 0 2,740,000 0 0
Pacira BioSciences COM 695127100 42,587 708,361 SH   DFND 1 708,361 0 0
Pacira BioSciences COM 695127100 27,978 465,371 SH   DFND 2 196,087 0 269,284
Pacira BioSciences COM 695127100 15,097 251,119 SH   DFND 3 215,545 0 35,574
Pacira BioSciences COM 695127100 20,088 334,138 SH   SOLE 0 334,138 0 0
Palantir Technologies Inc Class B Common COM 75943R102 40,776 5,624,297 SH   SOLE 0 5,624,297 0 0
Peloton Interactive Inc CL A COM 70614W100 151,945 1,531,087 SH   DFND 1 1,531,087 0 0
Peloton Interactive Inc CL A COM 70614W100 998,758 10,064,066 SH   DFND 2 3,380,390 0 6,683,676
Peloton Interactive Inc CL A COM 70614W100 73,064 736,238 SH   DFND 3 599,079 0 137,159
Peloton Interactive Inc CL A COM 70614W100 342,396 3,450,185 SH   SOLE 0 1,746,579 0 1,703,606
Penumbra Inc COM 70975L107 92,300 474,843 SH   DFND 1 474,843 0 0
Penumbra Inc COM 70975L107 93,285 479,911 SH   DFND 2 451,428 0 28,483
Penumbra Inc COM 70975L107 3,866 19,891 SH   DFND 3 19,891 0 0
Penumbra Inc COM 70975L107 23,332 120,032 SH   SOLE 0 120,032 0 0
Pepsico COM 713448108 27,273 196,772 SH   DFND 1 196,772 0 0
Pepsico COM 713448108 1,122 8,098 SH   DFND 2 0 0 8,098
Pepsico COM 713448108 42 302 SH   DFND 3 302 0 0
Pepsico COM 713448108 28,206 203,503 SH   SOLE 0 203,503 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 57,042 8,011,561 SH   DFND 1 8,011,561 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 252,886 35,517,675 SH   DFND 2 12,422,932 0 23,094,743
Petrobras Common ADR SPONSORED ADR 71654V408 47,371 6,653,269 SH   DFND 3 385,534 0 6,267,735
Petrobras Common ADR SPONSORED ADR 71654V408 2,570 360,954 SH   DFND 4 360,954 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 7,195 1,010,506 SH   SOLE 0 1,010,506 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 8,112 1,152,292 SH   DFND 1 1,152,292 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 59,860 8,502,785 SH   DFND 2 4,262,465 0 4,240,320
Pinduoduo Inc ADR SPONSORED ADS 722304102 158,385 2,136,003 SH   DFND 1 2,136,003 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 1,025,001 13,823,349 SH   DFND 2 4,520,158 0 9,303,191
Pinduoduo Inc ADR SPONSORED ADS 722304102 77,567 1,046,086 SH   DFND 3 854,168 0 191,918
Pinduoduo Inc ADR SPONSORED ADS 722304102 511,285 6,895,281 SH   SOLE 0 4,516,070 0 2,379,211
Procter & Gamble COM 742718109 36,714 264,152 SH   DFND 1 264,152 0 0
Procter & Gamble COM 742718109 1,525 10,970 SH   DFND 2 0 0 10,970
Procter & Gamble COM 742718109 56 403 SH   DFND 3 403 0 0
Procter & Gamble COM 742718109 37,770 271,747 SH   SOLE 0 271,747 0 0
Q2 Holdings Inc COM 74736L109 23,659 259,246 SH   DFND 1 259,246 0 0
Q2 Holdings Inc COM 74736L109 16,871 184,866 SH   DFND 2 68,110 0 116,756
Q2 Holdings Inc COM 74736L109 5,944 65,135 SH   DFND 3 65,135 0 0
Q2 Holdings Inc COM 74736L109 11,155 122,235 SH   SOLE 0 122,235 0 0
Redfin COM 75737F108 183,244 3,670,009 SH   DFND 1 3,670,009 0 0
Redfin COM 75737F108 176,970 3,544,359 SH   DFND 2 3,330,767 0 213,592
Redfin COM 75737F108 11,712 234,559 SH   DFND 3 187,916 0 46,643
Redfin COM 75737F108 47,211 945,539 SH   SOLE 0 945,539 0 0
Relay Therapeutics Inc COM 75943R102 1,234 28,978 SH   DFND 2 28,978 0 0
Relay Therapeutics Inc COM 75943R102 496 11,646 SH   DFND 3 11,646 0 0
ResMed COM 761152107 71,491 417,026 SH   DFND 1 417,026 0 0
ResMed COM 761152107 242,242 1,413,068 SH   DFND 2 1,309,414 0 103,654
ResMed COM 761152107 52,714 307,497 SH   DFND 3 142,079 0 165,418
ResMed COM 761152107 170,706 995,777 SH   SOLE 0 924,526 0 71,251
Ritchie Bros Auctioneers (USA) COM 767744105 31,781 536,391 SH   DFND 1 536,391 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 218,392 3,685,935 SH   DFND 2 3,240,544 0 445,391
Ritchie Bros Auctioneers (USA) COM 767744105 22,965 387,587 SH   DFND 3 174,637 0 212,950
Ritchie Bros Auctioneers (USA) COM 767744105 72,319 1,220,576 SH   SOLE 0 1,130,859 0 89,717
Ritchie Bros. Auctioneers COM 767744105 71,340 1,206,690 SH   DFND 2 667,162 0 539,528
Ritchie Bros. Auctioneers COM 767744105 25,654 433,928 SH   SOLE 0 433,928 0 0
Roku COM CL A 77543R102 206,344 1,092,925 SH   DFND 1 1,092,925 0 0
Roku COM CL A 77543R102 205,193 1,086,828 SH   DFND 2 1,019,176 0 67,652
Roku COM CL A 77543R102 6,217 32,929 SH   DFND 3 32,929 0 0
Roku COM CL A 77543R102 51,156 270,956 SH   SOLE 0 270,956 0 0
Rubius Therapeutics Inc COM 78116T103 2,259 450,800 SH   DFND 1 450,800 0 0
Rubius Therapeutics Inc COM 78116T103 828 165,310 SH   DFND 2 70,263 0 95,047
Rubius Therapeutics Inc COM 78116T103 392 78,186 SH   DFND 3 78,186 0 0
Rubius Therapeutics Inc COM 78116T103 17,934 3,579,565 SH   SOLE 0 3,579,565 0 0
Ryanair ADR SPONSORED ADR NE 783513203 855,064 10,458,218 SH   DFND 2 8,805,922 0 1,652,296
Ryanair ADR SPONSORED ADR NE 783513203 7,932 97,020 SH   DFND 3 15,032 0 81,988
Ryanair ADR SPONSORED ADR NE 783513203 10,358 126,691 SH   SOLE 0 126,691 0 0
S&P Global Inc COM 78409V104 37,322 103,501 SH   DFND 1 103,501 0 0
S&P Global Inc COM 78409V104 148,509 411,838 SH   DFND 2 372,757 0 39,081
S&P Global Inc COM 78409V104 27,079 75,095 SH   DFND 3 34,275 0 40,820
S&P Global Inc COM 78409V104 86,823 240,775 SH   SOLE 0 222,890 0 17,885
SEA Ltd ADR ADR 81141R100 333,672 2,166,137 SH   DFND 1 2,166,137 0 0
SEA Ltd ADR ADR 81141R100 626,338 4,066,076 SH   DFND 2 2,843,795 0 1,222,281
SEA Ltd ADR ADR 81141R100 97,423 632,452 SH   DFND 3 287,010 0 345,442
SEA Ltd ADR ADR 81141R100 368,730 2,393,730 SH   SOLE 0 2,248,439 0 145,291
SINA Corp ORD G81477104 5,605 131,550 SH   DFND 3 0 0 131,550
Sage Therapeutics Inc COM 78667J108 750 12,270 SH   DFND 2 12,270 0 0
Sage Therapeutics Inc COM 78667J108 291 4,760 SH   DFND 3 4,760 0 0
Salesforce.com COM 79466L302 132,333 526,550 SH   DFND 1 526,550 0 0
Salesforce.com COM 79466L302 893,446 3,555,012 SH   DFND 2 1,270,016 0 2,284,996
Salesforce.com COM 79466L302 63,529 252,783 SH   DFND 3 205,764 0 47,019
Salesforce.com COM 79466L302 296,360 1,179,215 SH   SOLE 0 595,503 0 583,712
Seagen Inc COM 81181C104 92,229 471,300 SH   DFND 1 471,300 0 0
Seagen Inc COM 81181C104 288,639 1,474,980 SH   DFND 2 1,321,831 0 153,149
Seagen Inc COM 81181C104 63,517 324,579 SH   DFND 3 160,884 0 163,695
Seagen Inc COM 81181C104 200,396 1,024,050 SH   SOLE 0 953,291 0 70,759
Service Corp.Intl. COM 817565104 64,184 1,521,671 SH   DFND 1 1,521,671 0 0
Service Corp.Intl. COM 817565104 212,672 5,042,020 SH   DFND 2 4,670,447 0 371,573
Service Corp.Intl. COM 817565104 45,512 1,078,995 SH   DFND 3 484,266 0 594,729
Service Corp.Intl. COM 817565104 144,639 3,429,078 SH   SOLE 0 3,176,613 0 252,465
Sherwin-Williams Co COM 824348106 13,293 19,079 SH   DFND 2 19,079 0 0
ShockWave Medical Inc COM 82489T104 10,542 139,072 SH   DFND 1 139,072 0 0
ShockWave Medical Inc COM 82489T104 12,262 161,763 SH   DFND 2 78,459 0 83,304
ShockWave Medical Inc COM 82489T104 4,373 57,697 SH   DFND 3 57,697 0 0
ShockWave Medical Inc COM 82489T104 6,511 85,892 SH   SOLE 0 85,892 0 0
Shopify 'A' CL A 82509L107 1,122,578 1,097,371 SH   DFND 1 1,097,371 0 0
Shopify 'A' CL A 82509L107 3,143,770 3,073,179 SH   DFND 2 2,122,074 0 951,105
Shopify 'A' CL A 82509L107 268,429 262,402 SH   DFND 3 165,211 0 97,191
Shopify 'A' CL A 82509L107 1,244,080 1,216,145 SH   SOLE 0 1,001,045 0 215,100
SiteOne Landscape Supply COM 82982L103 62,653 513,760 SH   DFND 1 513,760 0 0
SiteOne Landscape Supply COM 82982L103 206,819 1,695,934 SH   DFND 2 1,569,983 0 125,951
SiteOne Landscape Supply COM 82982L103 45,360 371,958 SH   DFND 3 168,124 0 203,834
SiteOne Landscape Supply COM 82982L103 140,871 1,155,156 SH   SOLE 0 1,069,741 0 85,415
Slack Technologies Inc COM CL A 83088V102 82,439 3,069,228 SH   DFND 1 3,069,228 0 0
Slack Technologies Inc COM CL A 83088V102 96,865 3,606,308 SH   DFND 2 3,416,663 0 189,645
Slack Technologies Inc COM CL A 83088V102 4,926 183,398 SH   DFND 3 149,928 0 33,470
Slack Technologies Inc COM CL A 83088V102 48,286 1,797,684 SH   SOLE 0 1,797,684 0 0
Snowflake Inc COM 833445109 50,621 201,676 SH   DFND 1 201,676 0 0
Snowflake Inc COM 833445109 93,064 370,772 SH   DFND 2 337,955 0 32,817
Snowflake Inc COM 833445109 13,352 53,195 SH   DFND 3 26,246 0 26,949
Snowflake Inc COM 833445109 93,455 372,332 SH   SOLE 0 360,739 0 11,593
Snowflake, Inc. Class B Common COM 833445909 75,805 302,011 SH   SOLE 0 302,011 0 0
Sohu.com COM 83410S108 3,975 200,140 SH   DFND 3 0 0 200,140
Splunk Inc COM 848637104 18,990 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 27,918 148,395 SH   DFND 2 54,232 0 94,163
Splunk Inc COM 848637104 9,744 51,794 SH   DFND 3 51,794 0 0
Splunk Inc COM 848637104 13,900 73,884 SH   SOLE 0 73,884 0 0
Spotify Technology SA SHS L8681T102 312,187 1,286,996 SH   DFND 1 1,286,996 0 0
Spotify Technology SA SHS L8681T102 3,898,100 16,070,000 SH   DFND 2 11,181,667 0 4,888,333
Spotify Technology SA SHS L8681T102 98,596 406,464 SH   DFND 3 284,182 0 122,282
Spotify Technology SA SHS L8681T102 886,642 3,655,201 SH   SOLE 0 3,071,979 0 583,222
Staar Surgical COM PAR $0.01 852312305 54,559 964,618 SH   DFND 1 964,618 0 0
Staar Surgical COM PAR $0.01 852312305 34,997 618,767 SH   DFND 2 248,196 0 370,571
Staar Surgical COM PAR $0.01 852312305 16,297 288,135 SH   DFND 3 259,377 0 28,758
Staar Surgical COM PAR $0.01 852312305 25,449 449,952 SH   SOLE 0 449,952 0 0
Stericycle Inc COM 858912108 40,299 639,054 SH   DFND 1 639,054 0 0
Stericycle Inc COM 858912108 140,134 2,222,234 SH   DFND 2 2,057,178 0 165,056
Stericycle Inc COM 858912108 29,488 467,621 SH   DFND 3 210,421 0 257,200
Stericycle Inc COM 858912108 96,479 1,529,948 SH   SOLE 0 1,422,443 0 107,505
Stitch Fix COM CL A 860897107 60,205 2,219,143 SH   DFND 1 2,219,143 0 0
Stitch Fix COM CL A 860897107 58,659 2,162,145 SH   DFND 2 2,036,497 0 125,648
Stitch Fix COM CL A 860897107 1,788 65,912 SH   DFND 3 65,912 0 0
Stitch Fix COM CL A 860897107 14,901 549,250 SH   SOLE 0 549,250 0 0
StoneCo COM CL A G85158106 6,722 127,088 SH   DFND 2 127,088 0 0
Stratasys SHS M85548101 2,822 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 4,887 391,930 SH   DFND 2 144,880 0 247,050
Stratasys SHS M85548101 1,686 135,240 SH   DFND 3 135,240 0 0
Stratasys SHS M85548101 1,803 144,600 SH   SOLE 0 144,600 0 0
Summit Therapeutics New Listing COM 86627T108 630 183,027 SH   DFND 1 183,027 0 0
Summit Therapeutics New Listing COM 86627T108 651 189,234 SH   SOLE 0 189,234 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 6,058 6,311,000 SH   DFND 1 6,311,000 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 4 4,000 SH   DFND 2 4,000 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 827 862,000 SH   DFND 3 862,000 0 0
Sutro Biopharma COM 869367102 10,476 1,042,428 SH   DFND 1 1,042,428 0 0
Sutro Biopharma COM 869367102 6,565 653,226 SH   SOLE 0 653,226 0 0
T. Rowe Price COM 74144T108 10,914 85,118 SH   DFND 1 85,118 0 0
T. Rowe Price COM 74144T108 374 2,917 SH   DFND 2 0 0 2,917
T. Rowe Price COM 74144T108 17 132 SH   DFND 3 132 0 0
T. Rowe Price COM 74144T108 11,470 89,452 SH   SOLE 0 89,452 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 124,096 1,631,978 SH   DFND 1 1,631,978 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 2,716,773 35,728,214 SH   DFND 2 26,880,893 0 8,847,321
TAL Education Group ADR ADS REPSTG COM 874080104 59,996 789,005 SH   DFND 3 641,459 0 147,546
TAL Education Group ADR ADS REPSTG COM 874080104 281,331 3,699,781 SH   SOLE 0 1,869,525 0 1,830,256
TD Ameritrade Holding Corp COM 87236Y108 34,501 881,258 SH   DFND 1 881,258 0 0
TD Ameritrade Holding Corp COM 87236Y108 120,317 3,073,229 SH   DFND 2 2,841,821 0 231,408
TD Ameritrade Holding Corp COM 87236Y108 26,570 678,666 SH   DFND 3 307,511 0 371,155
TD Ameritrade Holding Corp COM 87236Y108 82,731 2,113,184 SH   SOLE 0 1,959,225 0 153,959
TJX Companies COM 872540109 2,013 36,176 SH   DFND 1 36,176 0 0
TJX Companies COM 872540109 8,791 157,974 SH   DFND 2 157,974 0 0
TJX Companies COM 872540109 1,316 23,649 SH   DFND 3 15,086 0 8,563
TJX Companies COM 872540109 915 16,449 SH   SOLE 0 16,449 0 0
TSMC ADR SPONSORED ADR 874039100 39,281 484,535 SH   DFND 1 484,535 0 0
TSMC ADR SPONSORED ADR 874039100 613,965 7,573,275 SH   DFND 2 5,773,189 0 1,800,086
TSMC ADR SPONSORED ADR 874039100 14,601 180,102 SH   DFND 3 180,102 0 0
TSMC ADR SPONSORED ADR 874039100 116,758 1,440,207 SH   SOLE 0 1,264,339 0 175,868
Tabula Rasa HealthCare Inc COM 873379101 11,141 273,275 SH   DFND 1 273,275 0 0
Tabula Rasa HealthCare Inc COM 873379101 7,705 188,996 SH   DFND 2 69,505 0 119,491
Tabula Rasa HealthCare Inc COM 873379101 2,646 64,906 SH   DFND 3 64,906 0 0
Tabula Rasa HealthCare Inc COM 873379101 5,625 137,974 SH   SOLE 0 137,974 0 0
Tandem Diabetes Care COM NEW 875372203 16,672 146,892 SH   DFND 1 146,892 0 0
Tandem Diabetes Care COM NEW 875372203 16,841 148,377 SH   SOLE 0 148,377 0 0
Tata Motors Ltd ADR COM 876568502 9,844 1,082,939 SH   DFND 1 1,082,939 0 0
Tata Motors Ltd ADR COM 876568502 13 1,429 SH   DFND 3 1,429 0 0
Tata Motors Ltd ADR COM 876568502 10,699 1,177,015 SH   SOLE 0 1,177,015 0 0
Teladoc COM 87918A105 362,482 1,653,355 SH   DFND 1 1,653,355 0 0
Teladoc COM 87918A105 565,875 2,581,075 SH   DFND 2 2,179,035 0 402,040
Teladoc COM 87918A105 137,155 625,592 SH   DFND 3 376,716 0 248,876
Teladoc COM 87918A105 302,993 1,382,017 SH   SOLE 0 1,302,739 0 79,278
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 52,511 3,555,272 SH   DFND 1 3,555,272 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 431,834 29,237,261 SH   DFND 2 21,730,948 0 7,506,313
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 29,406 1,990,915 SH   DFND 3 896,630 0 1,094,285
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 121,784 8,245,389 SH   SOLE 0 7,784,905 0 460,484
Teradyne COM 880770102 71,260 896,800 SH   DFND 1 896,800 0 0
Teradyne COM 880770102 358,706 4,514,294 SH   DFND 2 4,292,023 0 222,271
Teradyne COM 880770102 51,341 646,120 SH   DFND 3 292,412 0 353,708
Teradyne COM 880770102 160,119 2,015,091 SH   SOLE 0 1,866,396 0 148,695
Tesla Inc COM 88160R101 1,675,561 3,905,646 SH   DFND 1 3,905,646 0 0
Tesla Inc COM 88160R101 8,643,874 20,148,421 SH   DFND 2 14,394,990 0 5,753,431
Tesla Inc COM 88160R101 485,646 1,132,015 SH   DFND 3 806,730 0 325,285
Tesla Inc COM 88160R101 4,084,370 9,520,453 SH   SOLE 0 8,255,054 0 1,265,399
The Trade Desk COM CL A 88339J105 483,604 932,195 SH   DFND 1 932,195 0 0
The Trade Desk COM CL A 88339J105 645,433 1,244,137 SH   DFND 2 1,161,384 0 82,753
The Trade Desk COM CL A 88339J105 73,663 141,993 SH   DFND 3 79,007 0 62,986
The Trade Desk COM CL A 88339J105 277,198 534,326 SH   SOLE 0 509,527 0 24,799
Thermo Fisher Scientific COM 883556102 129,812 294,012 SH   DFND 1 294,012 0 0
Thermo Fisher Scientific COM 883556102 467,586 1,059,037 SH   DFND 2 986,778 0 72,259
Thermo Fisher Scientific COM 883556102 93,144 210,961 SH   DFND 3 95,491 0 115,470
Thermo Fisher Scientific COM 883556102 297,528 673,873 SH   SOLE 0 625,181 0 48,692
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 7,292 234,156 SH   DFND 1 234,156 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 196,257 6,302,424 SH   DFND 2 4,650,537 0 1,651,887
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 30,772 988,171 SH   DFND 3 52,103 0 936,068
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 1,492 47,913 SH   DFND 4 47,913 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 128,431 4,124,323 SH   SOLE 0 4,124,323 0 0
Trupanion COM 898202106 15,591 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 29,209 370,206 SH   DFND 2 136,085 0 234,121
Trupanion COM 898202106 10,236 129,740 SH   DFND 3 129,740 0 0
Trupanion COM 898202106 57,992 735,000 SH   SOLE 0 735,000 0 0
Twilio Inc CL A 90138F102 205,832 833,024 SH   DFND 1 833,024 0 0
Twilio Inc CL A 90138F102 354,443 1,434,471 SH   DFND 2 1,324,812 0 109,659
Twilio Inc CL A 90138F102 37,980 153,710 SH   DFND 3 82,429 0 71,281
Twilio Inc CL A 90138F102 141,528 572,780 SH   SOLE 0 544,178 0 28,602
United Parcel Service CL B 911312106 40,839 245,087 SH   DFND 1 245,087 0 0
United Parcel Service CL B 911312106 1,580 9,481 SH   DFND 2 0 0 9,481
United Parcel Service CL B 911312106 61 369 SH   DFND 3 369 0 0
United Parcel Service CL B 911312106 41,763 250,632 SH   SOLE 0 250,632 0 0
Unity Biotechnology Inc COM 91381U101 858 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 12,300 3,555,014 SH   SOLE 0 3,555,014 0 0
Upwork Inc COM 91688F104 28,421 1,629,625 SH   DFND 1 1,629,625 0 0
Upwork Inc COM 91688F104 15,764 903,916 SH   DFND 2 352,227 0 551,689
Upwork Inc COM 91688F104 6,909 396,134 SH   DFND 3 366,068 0 30,066
Upwork Inc COM 91688F104 14,522 832,679 SH   SOLE 0 832,679 0 0
Uxin ADR ADS 91818X108 1,054 1,211,500 SH   DFND 1 1,211,500 0 0
Uxin ADR ADS 91818X108 491 564,600 SH   SOLE 0 564,600 0 0
Vale SA ADR ADR 91912E105 38,366 3,626,310 SH   DFND 1 3,626,310 0 0
Vale SA ADR ADR 91912E105 298,576 28,220,828 SH   DFND 2 12,512,960 0 15,707,868
Varian Medical Systems Inc COM 92220P105 11,182 65,009 SH   DFND 2 65,009 0 0
Veeco Instruments COM 922417100 6,849 586,854 SH   DFND 1 586,854 0 0
Veeco Instruments COM 922417100 6,360 544,989 SH   DFND 2 199,409 0 345,580
Veeco Instruments COM 922417100 2,192 187,816 SH   DFND 3 187,816 0 0
Verisk Analytics COM 92345Y106 12,265 66,186 SH   DFND 2 66,186 0 0
Vir Biotechnology Inc COM 92764N102 763 22,222 SH   DFND 2 22,222 0 0
Vir Biotechnology Inc COM 92764N102 317 9,229 SH   DFND 3 9,229 0 0
Vir Biotechnology Inc COM 92764N102 126,487 3,684,437 SH   SOLE 0 3,684,437 0 0
Visa Inc-Class A Shares COM CL A 92826C839 16,270 81,362 SH   DFND 2 81,362 0 0
Vroom Inc COM 92918V109 89,649 1,731,343 SH   DFND 1 1,731,343 0 0
Vroom Inc COM 92918V109 105,720 2,041,709 SH   DFND 2 1,916,794 0 124,915
Vroom Inc COM 92918V109 2,623 50,662 SH   DFND 3 50,662 0 0
Vroom Inc COM 92918V109 23,084 445,817 SH   SOLE 0 445,817 0 0
Vyne Therapeutics Inc COM 92941V100 323 194,824 SH   DFND 1 194,824 0 0
Vyne Therapeutics Inc COM 92941V100 332 200,225 SH   SOLE 0 200,225 0 0
WEC Energy Group COM 92939U106 1,285 13,262 SH   DFND 1 13,262 0 0
Wabtec COM 929740108 29,654 479,223 SH   DFND 1 479,223 0 0
Wabtec COM 929740108 110,521 1,786,054 SH   DFND 2 1,662,547 0 123,507
Wabtec COM 929740108 22,247 359,516 SH   DFND 3 163,543 0 195,973
Wabtec COM 929740108 69,368 1,121,011 SH   SOLE 0 1,036,163 0 84,848
Waters COM 941848103 3,552 18,152 SH   DFND 1 18,152 0 0
Waters COM 941848103 12,702 64,913 SH   DFND 2 64,913 0 0
Waters COM 941848103 2,209 11,290 SH   DFND 3 7,266 0 4,024
Waters COM 941848103 1,587 8,110 SH   SOLE 0 8,110 0 0
Watsco Inc COM 942622200 160,801 690,461 SH   DFND 2 651,745 0 38,716
Watsco Inc COM 942622200 165,349 709,987 SH   DFND 1 709,987 0 0
Watsco Inc COM 942622200 59,886 257,143 SH   SOLE 0 257,143 0 0
Watsco Inc COM 942622200 8,696 37,341 SH   DFND 3 30,166 0 7,175
Wayfair Inc Class A CL A 94419L101 592,745 2,036,853 SH   SOLE 0 2,007,112 0 29,741
Wayfair Inc Class A CL A 94419L101 84,485 290,316 SH   DFND 3 209,735 0 80,581
Wayfair Inc Class A CL A 94419L101 808,730 2,779,047 SH   DFND 2 2,491,519 0 287,528
Wayfair Inc Class A CL A 94419L101 703,958 2,419,016 SH   DFND 1 2,419,016 0 0
Wheaton Precious Metals COM 962879102 401 8,165 SH   DFND 1 8,165 0 0
Wix Com SHS M98068105 893,376 3,505,497 SH   DFND 2 1,897,785 0 1,607,712
Workday Inc CL A 98138H101 475,891 2,212,107 SH   SOLE 0 1,649,849 0 562,258
Workday Inc CL A 98138H101 292,095 1,357,762 SH   DFND 1 1,357,762 0 0
Workday Inc CL A 98138H101 930,930 4,327,289 SH   DFND 2 2,056,869 0 2,270,420
Workday Inc CL A 98138H101 65,637 305,106 SH   DFND 3 246,228 0 58,878
Xpeng Inc ADR ADR 98422D105 2 89 SH   DFND 3 89 0 0
Xpeng Inc ADR ADR 98422D105 1,268 63,188 SH   DFND 1 63,188 0 0
Xpeng Inc ADR ADR 98422D105 338 16,833 SH   SOLE 0 16,833 0 0
Xylem COM 98419M100 17,749 210,994 SH   DFND 3 111,727 0 99,267
Xylem COM 98419M100 37,944 451,075 SH   DFND 1 451,075 0 0
Xylem COM 98419M100 9,101 108,185 SH   DFND 2 71,998 0 36,187
Yext Inc COM 98585N106 66,808 4,401,084 SH   DFND 2 3,290,181 0 1,110,903
Yext Inc COM 98585N106 72,752 4,792,629 SH   DFND 1 4,792,629 0 0
Yext Inc COM 98585N106 26,077 1,717,834 SH   SOLE 0 1,717,834 0 0
Yext Inc COM 98585N106 10,552 695,109 SH   DFND 3 666,334 0 28,775
Zai Lab ADR ADR 98887Q104 29,509 354,800 SH   SOLE 0 354,800 0 0
Zai Lab ADR ADR 98887Q104 28,583 343,674 SH   DFND 3 159,174 0 184,500
Zai Lab ADR ADR 98887Q104 147,259 1,770,576 SH   DFND 2 860,955 0 909,621
Zai Lab ADR ADR 98887Q104 94,264 1,133,386 SH   DFND 1 1,133,386 0 0
Zillow Group Inc Class A CL A 98954M101 191,781 1,888,719 SH   DFND 2 1,707,335 0 181,384
Zillow Group Inc Class A CL A 98954M101 112,749 1,110,387 SH   DFND 1 1,110,387 0 0
Zillow Group Inc Class A CL A 98954M101 55,209 543,715 SH   SOLE 0 533,554 0 10,161
Zillow Group Inc Class A CL A 98954M101 10,435 102,764 SH   DFND 3 92,383 0 10,381
Zillow Group Inc Class C CL C CAP STK 98954M200 332,893 3,276,827 SH   SOLE 0 3,065,512 0 211,315
Zillow Group Inc Class C CL C CAP STK 98954M200 120,154 1,182,730 SH   DFND 3 673,772 0 508,958
Zillow Group Inc Class C CL C CAP STK 98954M200 490,671 4,829,917 SH   DFND 2 3,925,330 0 904,587
Zillow Group Inc Class C CL C CAP STK 98954M200 210,657 2,073,600 SH   DFND 1 2,073,600 0 0
Zoom Video Communications Inc CL A 98980L101 1,486,689 3,162,429 SH   DFND 2 1,524,213 0 1,638,216
Zoom Video Communications Inc CL A 98980L101 556,976 1,184,779 SH   DFND 1 1,184,779 0 0
Zoom Video Communications Inc CL A 98980L101 811,856 1,726,949 SH   SOLE 0 1,321,272 0 405,677
Zoom Video Communications Inc CL A 98980L101 104,321 221,907 SH   DFND 3 181,131 0 40,776
Zuora Inc Class A COM CL A 98983V106 2,537 245,311 SH   SOLE 0 245,311 0 0
Zuora Inc Class A COM CL A 98983V106 1,425 137,799 SH   DFND 3 137,799 0 0
Zuora Inc Class A COM CL A 98983V106 4,104 396,896 SH   DFND 2 146,765 0 250,131
Zuora Inc Class A COM CL A 98983V106 9,355 904,771 SH   DFND 1 904,771 0 0
iQIYI Inc ADR SPON ADR 46267X108 22 976 SH   DFND 3 976 0 0
iQIYI Inc ADR SPON ADR 46267X108 21,627 957,793 SH   DFND 1 957,793 0 0
iQIYI Inc ADR SPON ADR 46267X108 4,142 183,441 SH   SOLE 0 183,441 0 0
iRobot COM 462726100 14,052 185,136 SH   DFND 1 185,136 0 0
iRobot COM 462726100 18,024 237,475 SH   DFND 2 96,334 0 141,141
iRobot COM 462726100 8,626 113,655 SH   DFND 3 100,902 0 12,753
iRobot COM 462726100 24,274 319,820 SH   SOLE 0 319,820 0 0