The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 43,770 351,055 SH   DFND 1 350,177 0 878
ABBOTT LABS COM 002824100 80,062 735,665 SH   DFND 1 735,665 0 0
ABBVIE INC COM 00287Y109 47,833 546,099 SH   DFND 1 546,099 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 29,527 1,001,591 SH   DFND 1 1,001,591 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 5,222 177,133 SH   OTR 2 177,133 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,288 152,431 SH   DFND 1 152,431 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 8,435 37,323 SH   DFND 1 37,323 0 0
ACCOLADE INC COM 00437E102 11,410 293,554 SH   DFND 1 293,554 0 0
ACCOLADE INC COM 00437E102 2,039 52,455 SH   OTR 2 52,455 0 0
ACTIVISION BLIZZARD INC COM 00507V109 1,494 18,459 SH   DFND 1 18,459 0 0
ADECOAGRO S A COM L00849106 11,680 2,500,918 SH   DFND 1 2,500,918 0 0
ADECOAGRO S A COM L00849106 2,063 441,826 SH   OTR 2 441,826 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 3,347,136 6,824,901 SH   DFND 1 6,566,835 0 258,066
ADOBE SYSTEMS INCORPORATED COM 00724F101 52,601 107,254 SH   OTR 2 107,254 0 0
ADTALEM GLOBAL ED INC COM 00737L103 1,379 56,208 SH   DFND 1 56,208 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 38,441 250,429 SH   DFND 1 250,429 0 0
ADVANCED MICRO DEVICES INC COM 007903107 54,154 660,497 SH   DFND 1 657,506 0 2,991
AES CORP COM 00130H105 52,428 2,894,993 SH   DFND 1 2,894,993 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 46,627 461,930 SH   DFND 1 459,832 0 2,098
AGIOS PHARMACEUTICALS INC COM 00847X104 10,835 309,560 SH   DFND 1 309,560 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,664 47,551 SH   OTR 2 47,551 0 0
AGNICO EAGLE MINES LTD COM 008474108 40,337 506,679 SH   DFND 1 506,588 0 91
AIR PRODS & CHEMS INC COM 009158106 7,018 23,561 SH   DFND 1 23,555 0 6
AIR TRANSPORT SERVICES GRP I COM 00922R105 1,163 46,389 SH   DFND 1 46,389 0 0
ALCON AG ORD SHS H01301128 35,890 631,204 SH   DFND 1 631,127 0 77
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 16,271 101,691 SH   DFND 1 101,691 0 0
ALEXION PHARMACEUTICALS INC CALL OPTIONS 015351109 11,443 100,000 SH Call DFND 1 0 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 1,383,995 4,707,785 SH   DFND 1 4,518,229 0 189,556
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 27,920 94,974 SH   OTR 2 94,974 0 0
ALIGN TECHNOLOGY INC COM 016255101 47,712 145,749 SH   DFND 1 145,118 0 631
ALLEGHANY CORP DEL COM 017175100 9,411 18,083 SH   DFND 1 18,083 0 0
ALLIANT ENERGY CORP COM 018802108 100,267 1,941,275 SH   DFND 1 1,941,275 0 0
ALPHABET INC CAP STK CL A 02079K305 1,918,646 1,309,120 SH   DFND 1 1,261,945 0 47,175
ALPHABET INC CAP STK CL A 02079K305 19,380 13,223 SH   OTR 2 13,223 0 0
ALPHABET INC CAP STK CL C 02079K107 1,836,406 1,249,596 SH   DFND 1 1,187,618 0 61,978
ALPHABET INC CAP STK CL C 02079K107 19,359 13,173 SH   OTR 2 13,173 0 0
ALTRIA GROUP INC COM 02209S103 689 17,838 SH   DFND 1 17,838 0 0
AMAZON COM INC COM 023135106 8,628,619 2,740,349 SH   DFND 1 2,638,262 0 102,087
AMAZON COM INC COM 023135106 172,535 54,795 SH   OTR 2 54,795 0 0
AMEDISYS INC COM 023436108 1,474 6,233 SH   DFND 1 6,233 0 0
AMEREN CORP COM 023608102 191,970 2,427,548 SH   DFND 1 2,427,548 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 49,750 1,424,687 SH   DFND 1 1,424,687 0 0
AMERICAN ELEC PWR CO INC COM 025537101 225,285 2,756,452 SH   DFND 1 2,756,452 0 0
AMERICAN ELEC PWR CO INC UNIT 03/15/2022 025537127 7,413 152,813 SH   DFND 1 152,813 0 0
AMERICAN EQTY INVT LIFE HLD COM 025676206 1,301 59,148 SH   DFND 1 59,148 0 0
AMERICAN EXPRESS CO COM 025816109 558 5,570 SH   DFND 1 5,570 0 0
AMERICAN TOWER CORP NEW COM 03027X100 687,992 2,846,117 SH   DFND 1 2,703,379 0 142,738
AMERICAN TOWER CORP NEW COM 03027X100 5,593 23,139 SH   OTR 2 23,139 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 81,409 561,909 SH   DFND 1 561,909 0 0
AMERIS BANCORP COM 03076K108 26,636 1,169,244 SH   DFND 1 1,169,244 0 0
AMERIS BANCORP COM 03076K108 4,571 200,667 SH   OTR 2 200,667 0 0
AMERISOURCEBERGEN CORP COM 03073E105 2,880 29,713 SH   DFND 1 29,713 0 0
AMETEK INC COM 031100100 23,332 234,727 SH   DFND 1 233,634 0 1,093
AMGEN INC COM 031162100 5,481 21,567 SH   DFND 1 21,567 0 0
AMICUS THERAPEUTICS INC COM 03152W109 69,563 4,926,564 SH   DFND 1 4,926,564 0 0
AMICUS THERAPEUTICS INC COM 03152W109 6,117 433,241 SH   OTR 2 433,241 0 0
AMKOR TECHNOLOGY INC COM 031652100 1,786 159,490 SH   DFND 1 159,490 0 0
AMN HEALTHCARE SVCS INC COM 001744101 1,239 21,189 SH   DFND 1 21,189 0 0
AMPHENOL CORP NEW CL A 032095101 42,697 394,358 SH   DFND 1 392,648 0 1,710
ANTHEM INC COM 036752103 26,359 98,140 SH   DFND 1 98,140 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 82,027 2,718,834 SH   DFND 1 2,718,834 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,589 118,952 SH   OTR 2 118,952 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 25,096 560,802 SH   DFND 1 558,248 0 2,554
APPFOLIO INC COM CL A 03783C100 8,122 57,275 SH   DFND 1 57,275 0 0
APPLE INC COM 037833100 7,347,552 63,444,883 SH   DFND 1 61,153,363 0 2,291,520
APPLE INC COM 037833100 155,385 1,341,726 SH   OTR 2 1,341,726 0 0
APTIV PLC SHS G6095L109 33,638 366,912 SH   DFND 1 365,409 0 1,503
ARBOR REALTY TRUST INC COM 038923108 668 58,228 SH   DFND 1 58,228 0 0
ARCO PLATFORM LTD COM CL A G04553106 1,559 38,178 SH   DFND 1 38,178 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 992 23,116 SH   DFND 1 23,116 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 37,411 925,565 SH   DFND 1 922,726 0 2,839
ARGENX SE SPONSORED ADR 04016X101 112,192 427,365 SH   DFND 1 426,755 0 610
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 1,994 51,141 SH   DFND 1 51,141 0 0
ASBURY AUTOMOTIVE GROUP INC COM 043436104 928 9,518 SH   DFND 1 9,518 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 4,026 10,903 SH   DFND 1 10,882 0 21
ASSEMBLY BIOSCIENCES INC COM 045396108 38,821 2,361,403 SH   DFND 1 2,361,403 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 13,774 633,573 SH   DFND 1 633,573 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 2,230 102,591 SH   OTR 2 102,591 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,684,821 30,744,902 SH   DFND 1 29,948,670 0 796,232
ASTRAZENECA PLC SPONSORED ADR 046353108 15,922 290,556 SH   OTR 2 290,556 0 0
AT&T INC COM 00206R102 26,207 919,237 SH   DFND 1 919,237 0 0
ATKORE INTL GROUP INC COM 047649108 1,773 77,999 SH   DFND 1 77,999 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 6,021 281,774 SH   DFND 1 281,774 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 1,673 78,284 SH   OTR 2 78,284 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 5,278 184,481 SH   DFND 1 184,481 0 0
ATLASSIAN CORP PLC CL A G06242104 1,067,783 5,873,718 SH   DFND 1 5,717,338 0 156,380
ATLASSIAN CORP PLC CL A G06242104 23,076 126,939 SH   OTR 2 126,939 0 0
AVALARA INC COM 05338G106 53,749 422,091 SH   DFND 1 420,463 0 1,628
AVANGRID INC COM 05351W103 51,499 1,020,590 SH   DFND 1 1,020,590 0 0
AVANTOR INC COM 05352A100 43,933 1,953,456 SH   DFND 1 1,953,456 0 0
AVERY DENNISON CORP COM 053611109 1,276 9,984 SH   DFND 1 9,984 0 0
AVIENT CORPORATION COM 05368V106 48,231 1,822,814 SH   DFND 1 1,822,814 0 0
AVIENT CORPORATION COM 05368V106 6,695 253,005 SH   OTR 2 253,005 0 0
AXCELIS TECHNOLOGIES INC COM NEW 054540208 1,167 53,056 SH   DFND 1 53,056 0 0
AXIS CAP HLDGS LTD SHS G0692U109 25,482 578,623 SH   DFND 1 578,623 0 0
AXIS CAP HLDGS LTD SHS G0692U109 3,282 74,520 SH   OTR 2 74,520 0 0
AXOS FINANCIAL INC COM 05465C100 696 29,847 SH   DFND 1 29,847 0 0
AZEK CO INC CL A 05478C105 38,911 1,117,819 SH   DFND 1 1,114,387 0 3,432
AZEK CO INC CL A 05478C105 1,981 56,912 SH   OTR 2 56,912 0 0
B2GOLD CORP COM 11777Q209 2,386 366,535 SH   DFND 1 366,396 0 139
BANCORPSOUTH BK TUPELO MISS COM 05971J102 495 25,538 SH   DFND 1 25,538 0 0
BANDWIDTH INC COM CL A 05988J103 67,972 389,371 SH   DFND 1 389,371 0 0
BANDWIDTH INC COM CL A 05988J103 16,694 95,627 SH   OTR 2 95,627 0 0
BANKUNITED INC COM 06652K103 39,579 1,806,448 SH   DFND 1 1,806,448 0 0
BANKUNITED INC COM 06652K103 5,832 266,189 SH   OTR 2 266,189 0 0
BARNES GROUP INC COM 067806109 1,271 35,569 SH   DFND 1 35,569 0 0
BARRICK GOLD CORP COM 067901108 20,874 742,591 SH   DFND 1 742,321 0 270
BEAZER HOMES USA INC COM NEW 07556Q881 680 51,502 SH   DFND 1 51,502 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1,532 5,350 SH   DFND 1 5,350 0 0
BERKELEY LTS INC COM 084310101 3,614 47,329 SH   DFND 1 47,329 0 0
BERRY GLOBAL GROUP INC COM 08579W103 1,951 40,381 SH   DFND 1 40,381 0 0
BEST BUY INC COM 086516101 1,687 15,155 SH   DFND 1 15,155 0 0
BHP GROUP LTD SPONSORED ADS 088606108 15,971 308,864 SH   DFND 1 308,754 0 110
BIG LOTS INC COM 089302103 966 21,663 SH   DFND 1 21,663 0 0
BILIBILI INC SPONS ADS REP Z 090040106 2,555 61,426 SH   DFND 1 61,426 0 0
BIO RAD LABS INC CL A 090572207 4,951 9,605 SH   DFND 1 9,576 0 29
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 618 9,503 SH   DFND 1 9,503 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 49,664 652,792 SH   DFND 1 652,792 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 44,289 1,065,916 SH   DFND 1 1,065,916 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 7,042 169,480 SH   OTR 2 169,480 0 0
BK OF AMERICA CORP COM 060505104 100,439 4,169,342 SH   DFND 1 4,169,342 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 11,136 368,365 SH   DFND 1 368,365 0 0
BLACK HILLS CORP COM 092113109 567 10,600 SH   DFND 1 10,600 0 0
BLACKLINE INC COM 09239B109 10,863 121,193 SH   DFND 1 121,193 0 0
BLACKLINE INC COM 09239B109 3,527 39,355 SH   OTR 2 39,355 0 0
BLACKSTONE MTG TR INC COM CL A 09257W100 777 35,357 SH   DFND 1 35,357 0 0
BMC STK HLDGS INC COM 05591B109 485 11,331 SH   DFND 1 11,331 0 0
BOISE CASCADE CO DEL COM 09739D100 870 21,792 SH   DFND 1 21,792 0 0
BOOT BARN HLDGS INC COM 099406100 11,248 399,700 SH   DFND 1 399,700 0 0
BOOT BARN HLDGS INC COM 099406100 2,259 80,285 SH   OTR 2 80,285 0 0
BOOZ ALLEN HAMILTON HLDG COR CL A 099502106 2,245 27,057 SH   DFND 1 27,057 0 0
BOSTON BEER INC CL A 100557107 4,603 5,211 SH   DFND 1 5,211 0 0
BOSTON SCIENTIFIC CORP 5.50% CNV PFD A 101137206 1,126 10,065 SH   DFND 1 10,065 0 0
BOSTON SCIENTIFIC CORP COM 101137107 280,137 7,331,497 SH   DFND 1 6,898,567 0 432,930
BRIGHTHOUSE FINL INC COM 10922N103 3,310 123,003 SH   DFND 1 123,003 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 45,042 3,491,624 SH   DFND 1 3,491,624 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 6,129 475,118 SH   OTR 2 475,118 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 104,957 1,740,875 SH   DFND 1 1,740,875 0 0
BROADCOM INC COM 11135F101 107,951 296,307 SH   DFND 1 296,307 0 0
BROOKDALE SR LIVING INC COM 112463104 1,396 549,424 SH   DFND 1 549,424 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 2,448 41,771 SH   DFND 1 41,771 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 8,781 167,089 SH   DFND 1 167,089 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 4,843 560,268 SH   DFND 1 560,268 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 1,677 193,982 SH   OTR 2 193,982 0 0
BROOKS AUTOMATION INC NEW COM 114340102 45,285 978,925 SH   DFND 1 978,925 0 0
BROOKS AUTOMATION INC NEW COM 114340102 7,119 153,885 SH   OTR 2 153,885 0 0
BRUNSWICK CORP COM 117043109 43,902 745,239 SH   DFND 1 745,239 0 0
BRUNSWICK CORP COM 117043109 7,073 120,060 SH   OTR 2 120,060 0 0
BUCKLE INC COM 118440106 1,312 64,343 SH   DFND 1 64,343 0 0
BUILDERS FIRSTSOURCE INC COM 12008R107 2,295 70,361 SH   DFND 1 70,361 0 0
BURLINGTON STORES INC COM 122017106 46,295 224,635 SH   DFND 1 223,760 0 875
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 15,176 605,111 SH   DFND 1 605,111 0 0
BYLINE BANCORP INC COM 124411109 8,607 763,068 SH   DFND 1 763,068 0 0
BYLINE BANCORP INC COM 124411109 2,384 211,316 SH   OTR 2 211,316 0 0
CABOT OIL & GAS CORP COM 127097103 5,218 300,592 SH   DFND 1 300,485 0 107
CACTUS INC CL A 127203107 1,799 93,723 SH   DFND 1 93,723 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 5,432 50,938 SH   DFND 1 50,938 0 0
CAMPING WORLD HLDGS INC CL A 13462K109 677 22,766 SH   DFND 1 22,766 0 0
CANADIAN NATL RY CO COM 136375102 6,494 60,997 SH   DFND 1 60,997 0 0
CANNAE HLDGS INC COM 13765N107 1,107 29,714 SH   DFND 1 29,714 0 0
CAPITAL ONE FINL CORP COM 14040H105 59,956 834,347 SH   DFND 1 834,347 0 0
CARDLYTICS INC COM 14161W105 36,396 515,745 SH   DFND 1 515,745 0 0
CARDLYTICS INC COM 14161W105 5,834 82,666 SH   OTR 2 82,666 0 0
CARVANA CO CL A 146869102 421,164 1,888,124 SH   DFND 1 1,849,076 0 39,048
CARVANA CO CL A 146869102 10,147 45,488 SH   OTR 2 45,488 0 0
CATALENT INC COM 148806102 68,959 805,034 SH   DFND 1 802,808 0 2,226
CBIZ INC COM 124805102 858 37,521 SH   DFND 1 37,521 0 0
CDW CORP COM 12514G108 22,545 188,617 SH   DFND 1 188,586 0 31
CENTENE CORP DEL COM 15135B101 35,978 616,798 SH   DFND 1 616,798 0 0
CENTERPOINT ENERGY INC COM 15189T107 63,856 3,300,055 SH   DFND 1 3,300,055 0 0
CHANGE HEALTHCARE INC COM 15912K100 7,533 519,171 SH   DFND 1 519,171 0 0
CHANNELADVISOR CORP COM 159179100 528 36,488 SH   DFND 1 36,488 0 0
CHART INDS INC COM PAR $0.01 16115Q308 10,360 147,428 SH   DFND 1 147,376 0 52
CHARTER COMMUNICATIONS INC N CL A 16119P108 7,363 11,794 SH   DFND 1 11,794 0 0
CHENIERE ENERGY INC COM NEW 16411R208 91,250 1,972,117 SH   DFND 1 1,972,036 0 81
CHENIERE ENERGY PARTNERS LP COM UNIT 16411Q101 8,876 266,879 SH   DFND 1 266,879 0 0
CHEVRON CORP NEW COM 166764100 120,678 1,676,081 SH   DFND 1 1,676,030 0 51
CHEWY INC CL A 16679L109 182,935 3,336,406 SH   DFND 1 3,149,823 0 186,583
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,078,772 867,382 SH   DFND 1 833,003 0 34,379
CHIPOTLE MEXICAN GRILL INC COM 169656105 14,993 12,055 SH   OTR 2 12,055 0 0
CHUBB LIMITED COM H1467J104 113,866 980,591 SH   DFND 1 980,591 0 0
CHURCH & DWIGHT INC COM 171340102 44,198 471,651 SH   DFND 1 469,754 0 1,897
CIGNA CORP NEW COM 125523100 113,499 669,967 SH   DFND 1 669,967 0 0
CISCO SYS INC COM 17275R102 15,627 396,720 SH   DFND 1 396,720 0 0
CITIGROUP INC COM NEW 172967424 59,052 1,369,794 SH   DFND 1 1,369,794 0 0
CLEARWATER PAPER CORP COM 18538R103 1,487 39,197 SH   DFND 1 39,197 0 0
CLEARWAY ENERGY INC CL C 18539C204 9,764 362,181 SH   DFND 1 362,181 0 0
CMS ENERGY CORP COM 125896100 143,547 2,337,515 SH   DFND 1 2,337,515 0 0
CNO FINL GROUP INC COM 12621E103 1,976 123,217 SH   DFND 1 123,217 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 256 4,263 SH   DFND 1 4,263 0 0
COGNEX CORP COM 192422103 55,810 857,297 SH   DFND 1 854,679 0 2,618
COMCAST CORP NEW CL A 20030N101 28,868 624,047 SH   DFND 1 624,047 0 0
COMMERCIAL METALS CO COM 201723103 400 20,044 SH   DFND 1 20,044 0 0
CONCHO RES INC COM 20605P101 10,163 230,350 SH   DFND 1 230,271 0 79
CONOCOPHILLIPS COM 20825C104 67,236 2,047,394 SH   DFND 1 2,047,287 0 107
CONSTELLATION BRANDS INC CL A 21036P108 96,660 510,052 SH   DFND 1 357,135 0 152,917
CONSTELLATION PHARMCETICLS I COM 210373106 15,317 756,051 SH   DFND 1 756,051 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 1,573 77,632 SH   OTR 2 77,632 0 0
CONSTELLIUM SE CL A SHS F21107101 4,628 589,586 SH   DFND 1 589,348 0 238
CONSTRUCTION PARTNERS INC COM CL A 21044C107 3,423 188,090 SH   DFND 1 188,090 0 0
CONSTRUCTION PARTNERS INC COM CL A 21044C107 1,139 62,558 SH   OTR 2 62,558 0 0
COOPER COS INC COM NEW 216648402 27,556 81,738 SH   DFND 1 81,390 0 348
COSTAR GROUP INC COM 22160N109 57,010 67,188 SH   DFND 1 66,884 0 304
COSTCO WHSL CORP NEW COM 22160K105 1,273,186 3,586,441 SH   DFND 1 3,414,267 0 172,174
COSTCO WHSL CORP NEW COM 22160K105 15,695 44,211 SH   OTR 2 44,211 0 0
COUPA SOFTWARE INC COM 22266L106 1,164,400 4,245,917 SH   DFND 1 4,104,998 0 140,919
COUPA SOFTWARE INC COM 22266L106 18,269 66,617 SH   OTR 2 66,617 0 0
COUSINS PPTYS INC COM NEW 222795502 39,692 1,388,321 SH   DFND 1 1,388,321 0 0
COUSINS PPTYS INC COM NEW 222795502 5,089 177,985 SH   OTR 2 177,985 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 23,428 280,101 SH   DFND 1 280,101 0 0
CROCS INC COM 227046109 1,202 28,121 SH   DFND 1 28,121 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 832,186 6,060,197 SH   DFND 1 5,975,405 0 84,792
CROWDSTRIKE HLDGS INC CL A 22788C105 11,104 80,862 SH   OTR 2 80,862 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 30,544 183,448 SH   DFND 1 183,448 0 0
CROWN HLDGS INC COM 228368106 71,972 936,405 SH   DFND 1 934,746 0 1,659
CUE BIOPHARMA INC COM 22978P106 450 29,881 SH   DFND 1 29,881 0 0
CURTISS WRIGHT CORP COM 231561101 17,930 192,261 SH   DFND 1 192,261 0 0
CURTISS WRIGHT CORP COM 231561101 2,942 31,543 SH   OTR 2 31,543 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 25,561 247,151 SH   DFND 1 247,151 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 4,474 43,262 SH   OTR 2 43,262 0 0
CYTOKINETICS INC COM NEW 23282W605 5,854 270,382 SH   DFND 1 270,382 0 0
D R HORTON INC COM 23331A109 102,883 1,360,341 SH   DFND 1 1,360,341 0 0
DANAHER CORPORATION 4.75 MND CV PFD 235851300 1,128 764 SH   DFND 1 764 0 0
DANAHER CORPORATION COM 235851102 838,172 3,892,503 SH   DFND 1 3,709,085 0 183,418
DANAHER CORPORATION COM 235851102 6,222 28,894 SH   OTR 2 28,894 0 0
DARLING INGREDIENTS INC COM 237266101 61,531 1,707,766 SH   DFND 1 1,707,666 0 100
DARLING INGREDIENTS INC COM 237266101 8,890 246,732 SH   OTR 2 246,732 0 0
DEERE & CO COM 244199105 27,496 124,064 SH   DFND 1 124,064 0 0
DELL TECHNOLOGIES INC CL C 24703L202 3,134 46,299 SH   DFND 1 46,299 0 0
DENALI THERAPEUTICS INC COM 24823R105 13,749 383,727 SH   DFND 1 383,727 0 0
DEXCOM INC COM 252131107 1,100,590 2,669,844 SH   DFND 1 2,544,620 0 125,224
DEXCOM INC COM 252131107 28,040 68,021 SH   OTR 2 68,021 0 0
DIAMONDBACK ENERGY INC COM 25278X109 7,816 259,486 SH   DFND 1 259,391 0 95
DIAMONDROCK HOSPITALITY CO COM 252784301 840 165,659 SH   DFND 1 165,659 0 0
DISNEY WALT CO COM DISNEY 254687106 100,301 808,356 SH   DFND 1 808,356 0 0
DOCUSIGN INC COM 256163106 279,701 1,299,485 SH   DFND 1 1,191,717 0 107,768
DOCUSIGN INC COM 256163106 25,130 116,755 SH   OTR 2 116,755 0 0
DOLLAR GEN CORP NEW COM 256677105 61,897 295,282 SH   DFND 1 294,178 0 1,104
DOMINION ENERGY INC COM 25746U109 280,633 3,555,467 SH   DFND 1 3,555,467 0 0
DOUGLAS EMMETT INC COM 25960P109 7,436 296,255 SH   DFND 1 296,255 0 0
DOW INC COM 260557103 49,087 1,043,290 SH   DFND 1 1,043,255 0 35
DTE ENERGY CO COM 233331107 56,861 494,272 SH   DFND 1 494,272 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 68,075 768,688 SH   DFND 1 768,688 0 0
DUNKIN BRANDS GROUP INC COM 265504100 26,718 326,188 SH   DFND 1 324,816 0 1,372
DYNATRACE INC COM NEW 268150109 267,930 6,531,691 SH   DFND 1 5,983,654 0 548,037
DYNATRACE INC COM NEW 268150109 24,623 600,260 SH   OTR 2 600,260 0 0
DYNEX CAP INC COM 26817Q886 1,559 102,489 SH   DFND 1 102,489 0 0
EAST WEST BANCORP INC COM 27579R104 28,295 864,224 SH   DFND 1 864,224 0 0
EAST WEST BANCORP INC COM 27579R104 5,237 159,953 SH   OTR 2 159,953 0 0
EBAY INC. COM 278642103 5,323 102,176 SH   DFND 1 102,176 0 0
EDISON INTL COM 281020107 35,176 691,892 SH   DFND 1 691,892 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 264,860 3,318,212 SH   DFND 1 2,911,962 0 406,250
EDWARDS LIFESCIENCES CORP COM 28176E108 9,239 115,746 SH   OTR 2 115,746 0 0
EHEALTH INC COM 28238P109 21,382 270,652 SH   DFND 1 270,652 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 39,736 384,557 SH   DFND 1 384,557 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 7,036 68,091 SH   OTR 2 68,091 0 0
EMERSON ELEC CO COM 291011104 27,294 416,252 SH   DFND 1 416,252 0 0
ENBRIDGE INC COM 29250N105 57,434 1,966,624 SH   DFND 1 1,966,624 0 0
ENCORE CAP GROUP INC COM 292554102 663 17,180 SH   DFND 1 17,180 0 0
ENERGY TRANSFER LP COM UT LTD PTN 29273V100 8,178 1,508,947 SH   DFND 1 1,508,947 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 10,456 555,858 SH   DFND 1 555,858 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 3,382 179,797 SH   OTR 2 179,797 0 0
ENPHASE ENERGY INC COM 29355A107 5,844 70,764 SH   DFND 1 70,746 0 18
ENSTAR GROUP LIMITED SHS G3075P101 1,738 10,759 SH   DFND 1 10,759 0 0
ENTEGRIS INC COM 29362U104 1,740 23,405 SH   DFND 1 23,405 0 0
ENTERGY CORP NEW COM 29364G103 120,077 1,218,685 SH   DFND 1 1,218,685 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 9,717 356,326 SH   DFND 1 356,326 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 2,144 78,613 SH   OTR 2 78,613 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 18,910 1,197,604 SH   DFND 1 1,197,604 0 0
EPAM SYS INC COM 29414B104 4,887 15,118 SH   DFND 1 15,118 0 0
EQUINIX INC COM 29444U700 116,914 153,808 SH   DFND 1 153,806 0 2
EQUITRANS MIDSTREAM CORP COM 294600101 19,683 2,326,539 SH   DFND 1 2,326,539 0 0
ESSENT GROUP LTD COM G3198U102 872 23,563 SH   DFND 1 23,563 0 0
ESSENTIAL UTILS INC COM 29670G102 89,791 2,230,824 SH   DFND 1 2,230,824 0 0
ETSY INC COM 29786A106 60,814 499,993 SH   DFND 1 498,463 0 1,530
EVERBRIDGE INC COM 29978A104 34,289 272,724 SH   DFND 1 272,724 0 0
EVERBRIDGE INC COM 29978A104 6,011 47,807 SH   OTR 2 47,807 0 0
EVERSOURCE ENERGY COM 30040W108 35,909 429,793 SH   DFND 1 429,793 0 0
EVO PMTS INC CL A COM 26927E104 25,022 1,006,943 SH   DFND 1 1,006,943 0 0
EVO PMTS INC CL A COM 26927E104 7,744 311,626 SH   OTR 2 311,626 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 870 40,976 SH   DFND 1 40,976 0 0
EXELON CORP COM 30161N101 28,078 785,170 SH   DFND 1 785,170 0 0
F M C CORP COM NEW 302491303 138,731 1,309,891 SH   DFND 1 1,308,222 0 1,669
FACEBOOK INC CL A 30303M102 4,078,482 15,572,669 SH   DFND 1 15,035,335 0 537,334
FACEBOOK INC CL A 30303M102 47,988 183,232 SH   OTR 2 183,232 0 0
FASTENAL CO COM 311900104 1,430 31,718 SH   DFND 1 31,718 0 0
FATE THERAPEUTICS INC COM 31189P102 40,612 1,016,069 SH   DFND 1 1,016,069 0 0
FEDERATED HERMES INC CL B 314211103 950 44,188 SH   DFND 1 44,188 0 0
FEDEX CORP COM 31428X106 43,332 172,280 SH   DFND 1 172,280 0 0
FERRARI N V COM N3167Y103 23,022 125,061 SH   DFND 1 123,588 0 1,473
FIRST BANCORP N C COM 318910106 12,405 592,659 SH   DFND 1 592,659 0 0
FIRST BANCORP N C COM 318910106 3,538 169,047 SH   OTR 2 169,047 0 0
FIRST FNDTN INC COM 32026V104 16,267 1,244,539 SH   DFND 1 1,244,539 0 0
FIRST FNDTN INC COM 32026V104 2,919 223,367 SH   OTR 2 223,367 0 0
FIRSTENERGY CORP COM 337932107 107,251 3,735,659 SH   DFND 1 3,735,659 0 0
FIVE BELOW INC COM 33829M101 93,591 736,938 SH   DFND 1 735,428 0 1,510
FIVE BELOW INC COM 33829M101 7,695 60,593 SH   OTR 2 60,593 0 0
FIVE9 INC COM 338307101 21,192 163,421 SH   DFND 1 162,875 0 546
FLEETCOR TECHNOLOGIES INC COM 339041105 2,815 11,823 SH   DFND 1 11,801 0 22
FOCUS FINL PARTNERS INC COM CL A 34417P100 30,727 937,067 SH   DFND 1 937,067 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 4,922 150,119 SH   OTR 2 150,119 0 0
FORTIVE CORP COM 34959J108 48,931 642,057 SH   DFND 1 642,057 0 0
FREEPORT-MCMORAN INC CL B 35671D857 14,400 920,717 SH   DFND 1 920,375 0 342
FRESHPET INC COM 358039105 29,866 267,501 SH   DFND 1 266,937 0 564
FRESHPET INC COM 358039105 6,988 62,588 SH   OTR 2 62,588 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 29,191 790,444 SH   DFND 1 790,444 0 0
GENERAC HLDGS INC COM 368736104 6,681 34,500 SH   DFND 1 34,500 0 0
GENERAL MTRS CO COM 37045V100 89,808 3,035,086 SH   DFND 1 3,035,086 0 0
GENETRON HLDGS LTD ADS 37186H100 10,870 910,427 SH   DFND 1 910,427 0 0
GENMAB A/S SPONSORED ADS 372303206 39,539 1,079,997 SH   DFND 1 1,077,820 0 2,177
GFL ENVIRONMENTAL INC SUB VTG SHS 36168Q104 48,954 2,302,636 SH   DFND 1 2,296,490 0 6,146
GFL ENVIRONMENTAL INC UNIT 99/99/9999T 36168Q120 26,679 500,449 SH   DFND 1 500,449 0 0
GLACIER BANCORP INC NEW COM 37637Q105 945 29,478 SH   DFND 1 29,478 0 0
GLOBAL PMTS INC COM 37940X102 39,602 223,012 SH   DFND 1 222,006 0 1,006
GLOBANT S A COM L44385109 53,278 297,277 SH   DFND 1 296,676 0 601
GLOBANT S A COM L44385109 3,945 22,010 SH   OTR 2 22,010 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 945,922 4,706,781 SH   DFND 1 4,490,501 0 216,280
GOLDMAN SACHS GROUP INC COM 38141G104 8,911 44,341 SH   OTR 2 44,341 0 0
GOODRX HLDGS INC COM CL A 38246G108 38,920 700,000 SH   DFND 1 700,000 0 0
GOOSEHEAD INS INC COM CL A 38267D109 26,252 303,176 SH   DFND 1 303,176 0 0
GOOSEHEAD INS INC COM CL A 38267D109 7,419 85,674 SH   OTR 2 85,674 0 0
GOSSAMER BIO INC COM 38341P102 18,325 1,476,643 SH   DFND 1 1,476,643 0 0
GRAY TELEVISION INC COM 389375106 881 63,981 SH   DFND 1 63,981 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 42,375 4,455,792 SH   DFND 1 4,455,792 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 6,171 648,895 SH   OTR 2 648,895 0 0
GREENBRIER COS INC COM 393657101 1,177 40,048 SH   DFND 1 40,048 0 0
GUARDANT HEALTH INC COM 40131M109 351,416 3,143,820 SH   DFND 1 3,059,647 0 84,173
GUARDANT HEALTH INC COM 40131M109 3,759 33,625 SH   OTR 2 33,625 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 12,583 129,252 SH   DFND 1 129,252 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,669 27,418 SH   OTR 2 27,418 0 0
HAMILTON LANE INC CL A 407497106 12,838 198,763 SH   DFND 1 198,763 0 0
HAMILTON LANE INC CL A 407497106 3,150 48,775 SH   OTR 2 48,775 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 4,815 113,919 SH   DFND 1 113,879 0 40
HARSCO CORP COM 415864107 29,006 2,085,297 SH   DFND 1 2,085,297 0 0
HARSCO CORP COM 415864107 4,933 354,629 SH   OTR 2 354,629 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 7,633 354,500 SH   DFND 1 354,500 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 1,645 76,418 SH   OTR 2 76,418 0 0
HEALTHEQUITY INC COM 42226A107 9,517 185,272 SH   DFND 1 185,272 0 0
HEALTHEQUITY INC COM 42226A107 3,097 60,287 SH   OTR 2 60,287 0 0
HESS CORP COM 42809H107 7,855 191,902 SH   DFND 1 191,836 0 66
HILL ROM HLDGS INC COM 431475102 12,518 149,903 SH   DFND 1 149,903 0 0
HILLTOP HOLDINGS INC COM 432748101 792 38,461 SH   DFND 1 38,461 0 0
HOME DEPOT INC COM 437076102 1,560,023 5,617,451 SH   DFND 1 5,387,711 0 229,740
HOME DEPOT INC COM 437076102 15,754 56,730 SH   OTR 2 56,730 0 0
HONEYWELL INTL INC COM 438516106 2,386 14,496 SH   DFND 1 14,496 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 64,160 825,953 SH   DFND 1 825,362 0 591
HOULIHAN LOKEY INC CL A 441593100 19,518 330,530 SH   DFND 1 330,530 0 0
HOULIHAN LOKEY INC CL A 441593100 5,739 97,190 SH   OTR 2 97,190 0 0
HOWARD HUGHES CORP COM 44267D107 7,321 127,104 SH   DFND 1 127,104 0 0
HUBSPOT INC COM 443573100 57,152 195,571 SH   DFND 1 194,975 0 596
HUMANA INC COM 444859102 703,841 1,700,551 SH   DFND 1 1,618,483 0 82,068
HUMANA INC COM 444859102 8,072 19,503 SH   OTR 2 19,503 0 0
HUNT J B TRANS SVCS INC COM 445658107 66,630 527,216 SH   DFND 1 525,605 0 1,611
HURON CONSULTING GROUP INC COM 447462102 10,749 273,302 SH   DFND 1 273,302 0 0
HURON CONSULTING GROUP INC COM 447462102 3,497 88,918 SH   OTR 2 88,918 0 0
IDEX CORP COM 45167R104 34,151 187,220 SH   DFND 1 186,381 0 839
IHS MARKIT LTD SHS G47567105 44,400 565,535 SH   DFND 1 563,179 0 2,356
ILLINOIS TOOL WKS INC COM 452308109 953 4,930 SH   DFND 1 4,930 0 0
ILLUMINA INC COM 452327109 84,338 272,867 SH   DFND 1 230,480 0 42,387
IMMATICS N.V *W EXP 07/01/202 N44445117 1,351 386,035 SH   DFND 1 386,035 0 0
IMMUNOMEDICS INC CALL OPTIONS 452907108 17,006 200,000 SH Call DFND 1 0 0 0
IMMUNOMEDICS INC COM 452907108 176,608 2,077,004 SH   DFND 1 2,076,985 0 19
IMMUNOMEDICS INC COM 452907108 4,291 50,470 SH   OTR 2 50,470 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 28,420 2,452,071 SH   DFND 1 2,452,071 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 6,294 543,070 SH   OTR 2 543,070 0 0
INOVALON HLDGS INC COM CL A 45781D101 926 35,005 SH   DFND 1 35,005 0 0
INOVIO PHARMACEUTICALS INC PUT OPTIONS 45773H201 1,160 100,000 SH Put DFND 1 100,000 0 0
INPHI CORP COM 45772F107 33,980 302,716 SH   DFND 1 302,716 0 0
INPHI CORP COM 45772F107 9,465 84,320 SH   OTR 2 84,320 0 0
INSPIRE MED SYS INC COM 457730109 22,060 170,938 SH   DFND 1 170,938 0 0
INSPIRE MED SYS INC COM 457730109 6,456 50,030 SH   OTR 2 50,030 0 0
INSULET CORP COM 45784P101 62,698 265,008 SH   DFND 1 264,256 0 752
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 14,165 299,983 SH   DFND 1 299,983 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 2,730 57,813 SH   OTR 2 57,813 0 0
INTEL CORP COM 458140100 10,649 205,651 SH   DFND 1 205,651 0 0
INTERNATIONAL BANCSHARES COR COM 459044103 1,568 60,161 SH   DFND 1 60,161 0 0
INTERSECT ENT INC COM 46071F103 12,758 782,194 SH   DFND 1 782,194 0 0
INTERSECT ENT INC COM 46071F103 3,679 225,575 SH   OTR 2 225,575 0 0
INTUIT COM 461202103 446 1,366 SH   DFND 1 1,366 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 631,641 890,213 SH   DFND 1 838,147 0 52,066
INTUITIVE SURGICAL INC COM NEW 46120E602 4,359 6,143 SH   OTR 2 6,143 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 11,406 346,482 SH   DFND 1 346,482 0 0
IQVIA HLDGS INC COM 46266C105 71,478 453,456 SH   DFND 1 452,268 0 1,188
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,723 191,602 SH   DFND 1 191,602 0 0
ISHARES TR MSCI ACWI ETF 464288257 896 11,216 SH   DFND 1 11,176 0 40
ISHARES TR MSCI ACWI EX US 464288240 1,441 31,328 SH   DFND 1 31,328 0 0
ISHARES TR RUS 1000 GRW ETF 464287614 2,634 12,143 SH   DFND 1 11,316 0 827
JACK IN THE BOX INC COM 466367109 47,728 601,783 SH   DFND 1 601,783 0 0
JACK IN THE BOX INC COM 466367109 8,144 102,689 SH   OTR 2 102,689 0 0
JD.COM INC SPON ADR CL A 47215P106 2,785 35,886 SH   DFND 1 35,886 0 0
JELD-WEN HLDG INC COM 47580P103 15,840 700,850 SH   DFND 1 700,850 0 0
JELD-WEN HLDG INC COM 47580P103 5,126 226,830 SH   OTR 2 226,830 0 0
JOHNSON CTLS INTL PLC SHS G51502105 122,058 2,987,965 SH   DFND 1 2,987,965 0 0
JPMORGAN CHASE & CO COM 46625H100 196,823 2,044,491 SH   DFND 1 2,044,491 0 0
KAMAN CORP COM 483548103 16,376 420,227 SH   DFND 1 420,227 0 0
KAMAN CORP COM 483548103 2,675 68,647 SH   OTR 2 68,647 0 0
KB HOME COM 48666K109 3,465 90,246 SH   DFND 1 90,246 0 0
KENNAMETAL INC COM 489170100 17,216 594,884 SH   DFND 1 594,884 0 0
KENNAMETAL INC COM 489170100 4,521 156,210 SH   OTR 2 156,210 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 318 3,221 SH   DFND 1 3,221 0 0
KINDER MORGAN INC DEL COM 49456B101 15,789 1,280,533 SH   DFND 1 1,280,533 0 0
KINROSS GOLD CORP COM 496902404 17,594 1,994,831 SH   DFND 1 1,994,119 0 712
KKR & CO INC COM 48251W104 4,777 139,108 SH   DFND 1 139,108 0 0
KLA CORP COM NEW 482480100 4,671 24,111 SH   DFND 1 24,111 0 0
KNIGHT SWIFT TRANSN HLDGS IN CL A 499049104 13,635 335,011 SH   DFND 1 335,011 0 0
KONTOOR BRANDS INC COM 50050N103 31,960 1,320,668 SH   DFND 1 1,320,668 0 0
KONTOOR BRANDS INC COM 50050N103 7,229 298,722 SH   OTR 2 298,722 0 0
KYMERA THERAPEUTICS INC COM 501575104 2,262 70,024 SH   DFND 1 70,024 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 36,608 215,546 SH   DFND 1 214,611 0 935
LABORATORY CORP AMER HLDGS COM NEW 50540R409 65,485 347,825 SH   DFND 1 347,825 0 0
LADDER CAP CORP CL A 505743104 717 100,676 SH   DFND 1 100,676 0 0
LAM RESEARCH CORP COM 512807108 50,019 150,772 SH   DFND 1 150,362 0 410
LATTICE SEMICONDUCTOR CORP COM 518415104 27,665 955,273 SH   DFND 1 955,273 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 5,571 192,367 SH   OTR 2 192,367 0 0
LAUDER ESTEE COS INC CL A 518439104 1,000,159 4,582,627 SH   DFND 1 4,351,631 0 230,996
LAUDER ESTEE COS INC CL A 518439104 13,209 60,524 SH   OTR 2 60,524 0 0
LAZARD LTD SHS A G54050102 25,581 774,008 SH   DFND 1 774,008 0 0
LAZARD LTD SHS A G54050102 1,340 40,556 SH   OTR 2 40,556 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 4,178 135,357 SH   DFND 1 135,357 0 0
LEMONADE INC COM 52567D107 9,743 195,956 SH   DFND 1 195,956 0 0
LEMONADE INC COM 52567D107 1,752 35,240 SH   OTR 2 35,240 0 0
LEXINGTON REALTY TRUST COM 529043101 1,460 139,705 SH   DFND 1 139,705 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 5,088 53,374 SH   DFND 1 53,374 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 1,713 17,973 SH   OTR 2 17,973 0 0
LILLY ELI & CO COM 532457108 671,333 4,535,424 SH   DFND 1 4,322,028 0 213,396
LILLY ELI & CO COM 532457108 6,698 45,249 SH   OTR 2 45,249 0 0
LIMELIGHT NETWORKS INC COM 53261M104 494 85,830 SH   DFND 1 85,830 0 0
LINCOLN ELEC HLDGS INC COM 533900106 10,387 112,857 SH   DFND 1 112,857 0 0
LINDE PLC SHS G5494J103 211,321 887,417 SH   DFND 1 887,391 0 26
LITTELFUSE INC COM 537008104 38,280 215,856 SH   DFND 1 215,856 0 0
LITTELFUSE INC COM 537008104 6,743 38,023 SH   OTR 2 38,023 0 0
LIVERAMP HLDGS INC COM 53815P108 13,347 257,829 SH   DFND 1 257,829 0 0
LIVERAMP HLDGS INC COM 53815P108 4,366 84,327 SH   OTR 2 84,327 0 0
LOCKHEED MARTIN CORP COM 539830109 5,442 14,198 SH   DFND 1 14,198 0 0
LOWES COS INC COM 548661107 158,043 952,867 SH   DFND 1 952,867 0 0
LTC PPTYS INC COM 502175102 1,619 46,432 SH   DFND 1 46,432 0 0
LULULEMON ATHLETICA INC COM 550021109 2,309,874 7,013,006 SH   DFND 1 6,756,797 0 256,209
LULULEMON ATHLETICA INC COM 550021109 46,002 139,668 SH   OTR 2 139,668 0 0
LUMINEX CORP DEL COM 55027E102 779 29,668 SH   DFND 1 29,668 0 0
MACROGENICS INC COM 556099109 703 27,895 SH   DFND 1 27,895 0 0
MAG SILVER CORP COM 55903Q104 7,389 454,615 SH   DFND 1 454,454 0 161
MAGELLAN HEALTH INC COM NEW 559079207 1,580 20,848 SH   DFND 1 20,848 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 9,853 288,097 SH   DFND 1 288,097 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 1,448 94,267 SH   DFND 1 94,267 0 0
MALIBU BOATS INC COM CL A 56117J100 623 12,579 SH   DFND 1 12,579 0 0
MARINEMAX INC COM 567908108 1,001 39,001 SH   DFND 1 39,001 0 0
MARSH & MCLENNAN COS INC COM 571748102 63,375 552,528 SH   DFND 1 552,528 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 83,327 2,098,906 SH   DFND 1 2,091,807 0 7,099
MASONITE INTL CORP COM 575385109 1,167 11,859 SH   DFND 1 11,859 0 0
MASTERCARD INCORPORATED CL A 57636Q104 3,061,886 9,054,280 SH   DFND 1 8,678,989 0 375,291
MASTERCARD INCORPORATED CL A 57636Q104 55,281 163,472 SH   OTR 2 163,472 0 0
MATCH GROUP INC NEW COM 57667L107 1,766,912 15,968,481 SH   DFND 1 15,335,368 0 633,113
MATCH GROUP INC NEW COM 57667L107 40,903 369,658 SH   OTR 2 369,658 0 0
MAXAR TECHNOLOGIES INC COM 57778K105 757 30,370 SH   DFND 1 30,370 0 0
MAXLINEAR INC COM 57776J100 17,716 762,314 SH   DFND 1 762,314 0 0
MAXLINEAR INC COM 57776J100 5,589 240,475 SH   OTR 2 240,475 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 7,571 823,885 SH   DFND 1 823,885 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 2,416 262,889 SH   OTR 2 262,889 0 0
MCDONALDS CORP COM 580135101 80,503 366,775 SH   DFND 1 366,775 0 0
MCGRATH RENTCORP COM 580589109 501 8,415 SH   DFND 1 8,415 0 0
MCKESSON CORP COM 58155Q103 1,532 10,286 SH   DFND 1 10,286 0 0
MEDPACE HLDGS INC COM 58506Q109 990 8,859 SH   DFND 1 8,859 0 0
MERCADOLIBRE INC COM 58733R102 1,118,190 1,032,989 SH   DFND 1 987,452 0 45,537
MERCADOLIBRE INC COM 58733R102 53,819 49,718 SH   OTR 2 49,718 0 0
MERCK & CO. INC COM 58933Y105 2,121 25,565 SH   DFND 1 25,565 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 1,235 72,734 SH   DFND 1 72,734 0 0
MERITAGE HOMES CORP COM 59001A102 2,359 21,366 SH   DFND 1 21,366 0 0
METHODE ELECTRS INC COM 591520200 1,674 58,720 SH   DFND 1 58,720 0 0
METLIFE INC COM 59156R108 104,012 2,798,273 SH   DFND 1 2,798,273 0 0
MICHAELS COS INC COM 59408Q106 735 76,173 SH   DFND 1 76,173 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 36,038 350,699 SH   DFND 1 349,200 0 1,499
MICROSOFT CORP COM 594918104 5,462,792 25,972,481 SH   DFND 1 25,036,710 0 935,771
MICROSOFT CORP COM 594918104 91,448 434,783 SH   OTR 2 434,783 0 0
MOELIS & CO CL A 60786M105 9,023 256,790 SH   DFND 1 256,790 0 0
MOELIS & CO CL A 60786M105 2,805 79,815 SH   OTR 2 79,815 0 0
MOLINA HEALTHCARE INC COM 60855R100 73,593 402,061 SH   DFND 1 400,992 0 1,069
MOMENTA PHARMACEUTICALS INC COM 60877T100 583 11,116 SH   DFND 1 11,116 0 0
MONDELEZ INTL INC CL A 609207105 130,840 2,277,458 SH   DFND 1 2,277,458 0 0
MONOLITHIC PWR SYS INC COM 609839105 60,811 217,486 SH   DFND 1 216,843 0 643
MONRO INC COM 610236101 6,519 160,681 SH   DFND 1 160,681 0 0
MONRO INC COM 610236101 2,130 52,501 SH   OTR 2 52,501 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 2,357 29,392 SH   DFND 1 29,392 0 0
MOODYS CORP COM 615369105 1,479 5,103 SH   DFND 1 5,103 0 0
MPLX LP COM UNIT REP LTD 55336V100 17,857 1,134,528 SH   DFND 1 1,134,528 0 0
MUELLER WTR PRODS INC COM SER A 624758108 9,831 946,218 SH   DFND 1 946,218 0 0
MUELLER WTR PRODS INC COM SER A 624758108 2,629 253,028 SH   OTR 2 253,028 0 0
NATERA INC COM 632307104 142,221 1,968,730 SH   DFND 1 1,968,730 0 0
NATERA INC COM 632307104 11,244 155,641 SH   OTR 2 155,641 0 0
NATIONAL ENERGY SERVICES REU SHS G6375R107 5,254 823,437 SH   DFND 1 823,116 0 321
NATIONAL HEALTH INVS INC COM 63633D104 930 15,435 SH   DFND 1 15,435 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 23,956 732,375 SH   DFND 1 732,375 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 6,808 208,137 SH   OTR 2 208,137 0 0
NATIONAL VISION HLDGS INC COM 63845R107 26,713 698,571 SH   DFND 1 698,571 0 0
NATIONAL VISION HLDGS INC COM 63845R107 8,049 210,479 SH   OTR 2 210,479 0 0
NEOGENOMICS INC COM NEW 64049M209 11,689 316,857 SH   DFND 1 316,857 0 0
NEOGENOMICS INC COM NEW 64049M209 3,355 90,955 SH   OTR 2 90,955 0 0
NETFLIX INC COM 64110L106 3,968,474 7,936,472 SH   DFND 1 7,565,166 0 371,306
NETFLIX INC COM 64110L106 87,842 175,673 SH   OTR 2 175,673 0 0
NEVRO CORP COM 64157F103 44,023 316,028 SH   DFND 1 316,028 0 0
NEVRO CORP COM 64157F103 7,442 53,424 SH   OTR 2 53,424 0 0
NEW FORTRESS ENERGY INC COM CL A 644393100 6,923 157,304 SH   DFND 1 157,238 0 66
NEW JERSEY RES COM 646025106 597 22,100 SH   DFND 1 22,100 0 0
NEWMONT CORP COM 651639106 21,914 345,371 SH   DFND 1 345,252 0 119
NEXPOINT RESIDENTIAL TR INC COM 65341D102 1,783 40,196 SH   DFND 1 40,196 0 0
NEXTERA ENERGY INC COM 65339F101 303,482 1,093,394 SH   DFND 1 1,093,394 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F739 10,410 218,000 SH   DFND 1 218,000 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 198,879 3,316,855 SH   DFND 1 3,316,770 0 85
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 10,102 168,477 SH   OTR 2 168,477 0 0
NICE LTD SPONSORED ADR 653656108 85,691 377,445 SH   DFND 1 377,395 0 50
NIKE INC CL B 654106103 1,931,601 15,386,344 SH   DFND 1 14,718,426 0 667,918
NIKE INC CL B 654106103 31,080 247,569 SH   OTR 2 247,569 0 0
NISOURCE INC COM 65473P105 41,143 1,870,142 SH   DFND 1 1,870,142 0 0
NLIGHT INC COM 65487K100 22,796 970,866 SH   DFND 1 970,866 0 0
NLIGHT INC COM 65487K100 4,859 206,959 SH   OTR 2 206,959 0 0
NORDSON CORP COM 655663102 31,822 165,895 SH   DFND 1 165,146 0 749
NORFOLK SOUTHN CORP COM 655844108 14,008 65,463 SH   DFND 1 65,463 0 0
NORTHROP GRUMMAN CORP COM 666807102 61,505 194,950 SH   DFND 1 194,950 0 0
NORTONLIFELOCK INC COM 668771108 2,128 102,089 SH   DFND 1 102,089 0 0
NOVAVAX INC COM NEW 670002401 15,729 145,169 SH   DFND 1 145,169 0 0
NOVO-NORDISK A S ADR 670100205 70,010 1,008,360 SH   DFND 1 1,008,222 0 138
NURIX THERAPEUTICS INC COM 67080M103 6,988 200,160 SH   DFND 1 200,160 0 0
NUTRIEN LTD COM 67077M108 6,015 153,324 SH   DFND 1 153,267 0 57
NVIDIA CORPORATION COM 67066G104 4,414,928 8,157,364 SH   DFND 1 7,835,145 0 322,219
NVIDIA CORPORATION COM 67066G104 78,581 145,192 SH   OTR 2 145,192 0 0
OGE ENERGY CORP COM 670837103 30,177 1,006,249 SH   DFND 1 1,006,249 0 0
OKTA INC CL A 679295105 72,825 340,544 SH   DFND 1 339,897 0 647
OLD DOMINION FREIGHT LINE IN COM 679580100 4,744 26,221 SH   DFND 1 26,221 0 0
ON SEMICONDUCTOR CORP COM 682189105 8,630 397,859 SH   DFND 1 397,859 0 0
ONE GAS INC COM 68235P108 840 12,172 SH   DFND 1 12,172 0 0
ONEOK INC NEW COM 682680103 7,964 306,527 SH   DFND 1 306,527 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 54,626 118,474 SH   DFND 1 117,971 0 503
ORIC PHARMACEUTICALS INC COM 68622P109 3,767 150,601 SH   DFND 1 150,601 0 0
OTIS WORLDWIDE CORP COM 68902V107 67,719 1,084,894 SH   DFND 1 1,084,894 0 0
OUTSET MED INC COM 690145107 10,057 201,133 SH   DFND 1 201,133 0 0
OUTSET MED INC COM 690145107 933 18,668 SH   OTR 2 18,668 0 0
OWENS & MINOR INC NEW COM 690732102 885 35,259 SH   DFND 1 35,259 0 0
PAGERDUTY INC COM 69553P100 16,781 619,008 SH   DFND 1 619,008 0 0
PAGERDUTY INC COM 69553P100 2,449 90,341 SH   OTR 2 90,341 0 0
PALO ALTO NETWORKS INC COM 697435105 46,017 188,015 SH   DFND 1 187,161 0 854
PARSLEY ENERGY INC CL A 701877102 10,427 1,113,984 SH   DFND 1 1,113,570 0 414
PATRICK INDS INC COM 703343103 943 16,387 SH   DFND 1 16,387 0 0
PAYCOM SOFTWARE INC COM 70432V102 32,178 103,368 SH   DFND 1 102,900 0 468
PAYPAL HLDGS INC COM 70450Y103 2,162,144 10,973,676 SH   DFND 1 10,560,031 0 413,645
PAYPAL HLDGS INC COM 70450Y103 24,263 123,145 SH   OTR 2 123,145 0 0
PDC ENERGY INC COM 69327R101 5,138 414,550 SH   DFND 1 414,394 0 156
PELOTON INTERACTIVE INC CL A COM 70614W100 1,027,119 10,349,853 SH   DFND 1 9,966,980 0 382,873
PELOTON INTERACTIVE INC CL A COM 70614W100 41,393 417,098 SH   OTR 2 417,098 0 0
PEMBINA PIPELINE CORP COM 706327103 16,933 797,777 SH   DFND 1 797,777 0 0
PENN NATL GAMING INC COM 707569109 45,675 628,263 SH   DFND 1 628,263 0 0
PENN NATL GAMING INC COM 707569109 5,459 75,096 SH   OTR 2 75,096 0 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 764 13,138 SH   DFND 1 13,138 0 0
PENTAIR PLC SHS G7S00T104 19,714 430,722 SH   DFND 1 430,722 0 0
PEPSICO INC COM 713448108 95,923 692,085 SH   DFND 1 692,085 0 0
PERFICIENT INC COM 71375U101 1,813 42,414 SH   DFND 1 42,414 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 65,703 1,897,826 SH   DFND 1 1,897,826 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 10,289 297,210 SH   OTR 2 297,210 0 0
PETMED EXPRESS INC COM 716382106 714 22,577 SH   DFND 1 22,577 0 0
PHILIP MORRIS INTL INC COM 718172109 666 8,876 SH   DFND 1 8,876 0 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 6,430 279,095 SH   DFND 1 279,095 0 0
PHREESIA INC COM 71944F106 41,500 1,291,613 SH   DFND 1 1,291,613 0 0
PHREESIA INC COM 71944F106 5,724 178,151 SH   OTR 2 178,151 0 0
PHYSICIANS RLTY TR COM 71943U104 16,905 943,892 SH   DFND 1 943,892 0 0
PHYSICIANS RLTY TR COM 71943U104 2,743 153,135 SH   OTR 2 153,135 0 0
PIEDMONT OFFICE REALTY TR IN COM CL A 720190206 1,583 116,686 SH   DFND 1 116,686 0 0
PING IDENTITY HLDG CORP COM 72341T103 668 21,415 SH   DFND 1 21,415 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 39,575 1,111,970 SH   DFND 1 1,111,970 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 5,630 158,189 SH   OTR 2 158,189 0 0
PINTEREST INC CL A 72352L106 69,438 1,672,798 SH   DFND 1 1,667,508 0 5,290
PIONEER NAT RES CO COM 723787107 9,485 110,299 SH   DFND 1 110,261 0 38
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 4,816 805,433 SH   DFND 1 805,433 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 3,101 509,189 SH   DFND 1 509,189 0 0
PLEXUS CORP COM 729132100 751 10,635 SH   DFND 1 10,635 0 0
PLURALSIGHT INC COM CL A 72941B106 8,321 485,725 SH   DFND 1 485,725 0 0
PLURALSIGHT INC COM CL A 72941B106 1,458 85,119 SH   OTR 2 85,119 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 5,325 150,000 SH   DFND 1 150,000 0 0
PNC FINL SVCS GROUP INC COM 693475105 111,592 1,015,303 SH   DFND 1 1,015,303 0 0
PNM RES INC COM 69349H107 27,708 670,398 SH   DFND 1 670,398 0 0
PNM RES INC COM 69349H107 4,705 113,844 SH   OTR 2 113,844 0 0
POOL CORP COM 73278L105 6,714 20,068 SH   DFND 1 20,068 0 0
POWER INTEGRATIONS INC COM 739276103 1,982 35,785 SH   DFND 1 35,785 0 0
PPD INC COM 69355F102 81,219 2,195,700 SH   DFND 1 2,189,763 0 5,937
PRA GROUP INC COM 69354N106 902 22,568 SH   DFND 1 22,568 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 16,035 440,268 SH   DFND 1 440,268 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 4,235 116,282 SH   OTR 2 116,282 0 0
PRIMORIS SVCS CORP COM 74164F103 1,690 93,691 SH   DFND 1 93,691 0 0
PROCTER AND GAMBLE CO COM 742718109 98,984 712,167 SH   DFND 1 712,167 0 0
PROLOGIS INC. COM 74340W103 35,192 349,750 SH   DFND 1 349,750 0 0
PROOFPOINT INC COM 743424103 9,913 93,921 SH   DFND 1 93,921 0 0
PROOFPOINT INC COM 743424103 2,897 27,447 SH   OTR 2 27,447 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 12,618 2,634,140 SH   DFND 1 2,634,140 0 0
PROSIGHT GLOBAL INC COM 74349J103 8,270 729,284 SH   DFND 1 729,284 0 0
PROSIGHT GLOBAL INC COM 74349J103 1,351 119,119 SH   OTR 2 119,119 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 1,260 1,145,740 SH   DFND 1 1,145,740 0 0
PTC INC COM 69370C100 40,159 485,483 SH   DFND 1 485,483 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 82,882 1,509,409 SH   DFND 1 1,509,409 0 0
PURPLE INNOVATION INC COM 74640Y106 681 27,374 SH   DFND 1 27,374 0 0
Q2 HLDGS INC COM 74736L109 32,950 361,053 SH   DFND 1 361,053 0 0
Q2 HLDGS INC COM 74736L109 9,465 103,716 SH   OTR 2 103,716 0 0
QTS RLTY TR INC COM CL A 74736A103 56,667 899,189 SH   DFND 1 899,189 0 0
QTS RLTY TR INC COM CL A 74736A103 9,805 155,584 SH   OTR 2 155,584 0 0
QUALCOMM INC COM 747525103 124,771 1,060,255 SH   DFND 1 1,060,255 0 0
QUALYS INC COM 74758T303 491 5,014 SH   DFND 1 5,014 0 0
QUANTA SVCS INC COM 74762E102 71,389 1,350,528 SH   DFND 1 1,347,610 0 2,918
RAYTHEON TECHNOLOGIES CORP COM 75513E101 104,195 1,810,819 SH   DFND 1 1,810,819 0 0
REGENERON PHARMACEUTICALS COM 75886F107 37,440 66,884 SH   DFND 1 66,884 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 52,318 308,223 SH   DFND 1 307,881 0 342
RENASANT CORP COM 75970E107 9,904 435,879 SH   DFND 1 435,879 0 0
RENASANT CORP COM 75970E107 2,759 121,456 SH   OTR 2 121,456 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 5,897 110,387 SH   DFND 1 110,348 0 39
REPLIGEN CORP COM 759916109 29,022 196,709 SH   DFND 1 196,709 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 15,701 1,507,553 SH   DFND 1 1,507,553 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 2,627 252,201 SH   OTR 2 252,201 0 0
REVANCE THERAPEUTICS INC COM 761330109 51,904 2,064,608 SH   DFND 1 2,064,608 0 0
REVANCE THERAPEUTICS INC COM 761330109 5,567 221,434 SH   OTR 2 221,434 0 0
REXNORD CORP COM 76169B102 59,247 1,985,489 SH   DFND 1 1,985,489 0 0
REXNORD CORP COM 76169B102 8,760 293,558 SH   OTR 2 293,558 0 0
RIBBIT LEAP LTD UNIT 99/99/9999 G7552B121 7,160 550,799 SH   DFND 1 550,799 0 0
RINGCENTRAL INC CL A 76680R206 1,360,568 4,954,546 SH   DFND 1 4,729,055 0 225,491
RINGCENTRAL INC CL A 76680R206 41,548 151,300 SH   OTR 2 151,300 0 0
RIO TINTO PLC SPONSORED ADR 767204100 514 8,511 SH   DFND 1 8,454 0 57
ROLLINS INC COM 775711104 1,500 27,682 SH   DFND 1 27,682 0 0
ROSS STORES INC COM 778296103 82,206 880,900 SH   DFND 1 880,893 0 7
ROYAL GOLD INC COM 780287108 14,926 124,210 SH   DFND 1 124,210 0 0
RUSH ENTERPRISES INC CL A 781846209 13,546 268,023 SH   DFND 1 268,023 0 0
RUSH ENTERPRISES INC CL A 781846209 3,039 60,124 SH   OTR 2 60,124 0 0
S&P GLOBAL INC COM 78409V104 1,181,525 3,276,555 SH   DFND 1 3,151,873 0 124,682
S&P GLOBAL INC COM 78409V104 12,686 35,179 SH   OTR 2 35,179 0 0
SAGE THERAPEUTICS INC COM 78667J108 26,793 438,365 SH   DFND 1 438,365 0 0
SAIA INC COM 78709Y105 71,897 569,981 SH   DFND 1 569,981 0 0
SAIA INC COM 78709Y105 12,388 98,209 SH   OTR 2 98,209 0 0
SALESFORCE COM INC COM 79466L302 3,245,871 12,915,288 SH   DFND 1 12,285,740 0 629,548
SALESFORCE COM INC COM 79466L302 31,013 123,402 SH   OTR 2 123,402 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 10,158 1,203,630 SH   DFND 1 1,203,630 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 2,792 330,760 SH   OTR 2 330,760 0 0
SAP SE SPON ADR 803054204 94,069 603,742 SH   DFND 1 603,742 0 0
SAREPTA THERAPEUTICS INC COM 803607100 362,484 2,581,247 SH   DFND 1 2,561,736 0 19,511
SAREPTA THERAPEUTICS INC COM 803607100 3,346 23,825 SH   OTR 2 23,825 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 117,391 368,598 SH   DFND 1 367,934 0 664
SCHLUMBERGER LTD COM 806857108 4,061 261,006 SH   DFND 1 260,898 0 108
SCHWEITZER-MAUDUIT INTL INC COM 808541106 609 20,032 SH   DFND 1 20,032 0 0
SEA LTD SPONSORD ADS 81141R100 174,268 1,131,315 SH   DFND 1 1,131,153 0 162
SEACOAST BKG CORP FLA COM NEW 811707801 9,780 542,423 SH   DFND 1 542,423 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 1,565 86,800 SH   OTR 2 86,800 0 0
SEATTLE GENETICS INC COM 812578102 58,815 300,553 SH   DFND 1 299,767 0 786
SELECT MED HLDGS CORP COM 81619Q105 2,056 98,737 SH   DFND 1 98,737 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 254 8,486 SH   DFND 1 8,432 0 54
SELECTQUOTE INC COM 816307300 12,197 602,327 SH   DFND 1 602,327 0 0
SEMPRA ENERGY 6% PFD CONV A 816851406 14,565 147,944 SH   DFND 1 147,944 0 0
SEMPRA ENERGY COM 816851109 72,100 609,156 SH   DFND 1 609,156 0 0
SERVICE CORP INTL COM 817565104 1,922 45,558 SH   DFND 1 45,558 0 0
SERVICENOW INC COM 81762P102 933,434 1,924,608 SH   DFND 1 1,877,120 0 47,488
SERVICENOW INC COM 81762P102 10,330 21,298 SH   OTR 2 21,298 0 0
SHIFT4 PMTS INC CL A 82452J109 27,303 564,580 SH   DFND 1 564,580 0 0
SHIFT4 PMTS INC CL A 82452J109 6,107 126,273 SH   OTR 2 126,273 0 0
SHOCKWAVE MED INC COM 82489T104 44,186 582,934 SH   DFND 1 582,934 0 0
SHOPIFY INC CL A 82509L107 3,393,401 3,317,205 SH   DFND 1 3,214,604 0 102,601
SHOPIFY INC CL A 82509L107 78,406 76,645 SH   OTR 2 76,645 0 0
SILK RD MED INC COM 82710M100 76,295 1,135,171 SH   DFND 1 1,135,171 0 0
SILK RD MED INC COM 82710M100 8,038 119,592 SH   OTR 2 119,592 0 0
SIMULATIONS PLUS INC COM 829214105 11,799 156,576 SH   DFND 1 156,576 0 0
SIMULATIONS PLUS INC COM 829214105 2,239 29,706 SH   OTR 2 29,706 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 976 48,098 SH   DFND 1 48,098 0 0
SLM CORP COM 78442P106 44,413 5,489,857 SH   DFND 1 5,489,857 0 0
SMARTSHEET INC COM CL A 83200N103 12,302 248,920 SH   DFND 1 248,920 0 0
SNOWFLAKE INC CL A 833445109 4,512 17,979 SH   DFND 1 17,424 0 555
SNOWFLAKE INC CL A 833445109 395 1,572 SH   OTR 2 1,572 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 1,586 6,653 SH   DFND 1 6,653 0 0
SOUTH JERSEY INDS INC COM 838518108 1,912 99,208 SH   DFND 1 99,208 0 0
SOUTHERN COPPER CORP COM 84265V105 16,092 355,473 SH   DFND 1 355,340 0 133
SOUTHWEST GAS HOLDINGS INC COM 844895102 595 9,437 SH   DFND 1 9,437 0 0
SPARTANNASH CO COM 847215100 647 39,559 SH   DFND 1 39,559 0 0
SPDR SER TR PUT OPTIONS 78464A870 27,858 250,000 SH Put DFND 1 250,000 0 0
SPDR SER TR S&P METALS MNG 78464A755 3,472 149,405 SH   DFND 1 148,435 0 970
SPLUNK INC COM 848637104 1,000,638 5,318,865 SH   DFND 1 5,043,998 0 274,867
SPLUNK INC COM 848637104 12,575 66,842 SH   OTR 2 66,842 0 0
SPORTSMANS WHSE HLDGS INC COM 84920Y106 764 53,375 SH   DFND 1 53,375 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 998,161 4,114,938 SH   DFND 1 4,022,622 0 92,316
SPOTIFY TECHNOLOGY S A SHS L8681T102 9,979 41,139 SH   OTR 2 41,139 0 0
SPROUTS FMRS MKT INC COM 85208M102 22,274 1,064,229 SH   DFND 1 1,064,229 0 0
SPROUTS FMRS MKT INC COM 85208M102 2,834 135,391 SH   OTR 2 135,391 0 0
SQUARE INC CL A 852234103 4,215 25,930 SH   DFND 1 25,930 0 0
SSR MNG INC COM 784730103 5,383 288,501 SH   DFND 1 288,398 0 103
STAG INDL INC COM 85254J102 2,391 78,423 SH   DFND 1 78,423 0 0
STARWOOD PPTY TR INC COM 85571B105 8,185 542,416 SH   DFND 1 542,416 0 0
STEELCASE INC CL A 858155203 1,385 137,007 SH   DFND 1 137,007 0 0
STEPSTONE GROUP INC COM CL A 85914M107 1,690 63,517 SH   DFND 1 63,517 0 0
STEPSTONE GROUP INC COM CL A 85914M107 571 21,451 SH   OTR 2 21,451 0 0
STRYKER CORPORATION COM 863667101 365 1,751 SH   DFND 1 1,751 0 0
STURM RUGER & CO INC COM 864159108 729 11,916 SH   DFND 1 11,916 0 0
SUMMIT MATLS INC CL A 86614U100 52,554 3,177,385 SH   DFND 1 3,177,385 0 0
SUMMIT MATLS INC CL A 86614U100 8,232 497,698 SH   OTR 2 497,698 0 0
SUNCOR ENERGY INC NEW COM 867224107 19,830 1,621,399 SH   DFND 1 1,621,167 0 232
SUNNOVA ENERGY INTL INC. COM 86745K104 19,289 634,293 SH   DFND 1 634,063 0 230
SUNPOWER CORP COM 867652406 19,425 1,552,797 SH   DFND 1 1,552,690 0 107
SUNPOWER CORP COM 867652406 3,165 252,968 SH   OTR 2 252,968 0 0
SUNRUN INC COM 86771W105 24,399 316,585 SH   DFND 1 316,452 0 133
SYKES ENTERPRISES INC COM 871237103 1,823 53,282 SH   DFND 1 53,282 0 0
SYNEOS HEALTH INC CL A 87166B102 23,360 439,426 SH   DFND 1 439,426 0 0
SYNEOS HEALTH INC CL A 87166B102 4,957 93,242 SH   OTR 2 93,242 0 0
SYNOPSYS INC COM 871607107 5,434 25,393 SH   DFND 1 25,393 0 0
SYSCO CORP COM 871829107 248 3,993 SH   DFND 1 3,993 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 120,096 1,481,388 SH   DFND 1 1,481,206 0 182
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 48,388 292,870 SH   DFND 1 291,493 0 1,377
TANDEM DIABETES CARE INC COM NEW 875372203 56,990 502,111 SH   DFND 1 502,111 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 7,077 62,356 SH   OTR 2 62,356 0 0
TARGA RES CORP COM 87612G101 11,395 812,187 SH   DFND 1 812,187 0 0
TAYLOR MORRISON HOME CORP COM 87724P106 899 36,551 SH   DFND 1 36,551 0 0
TC ENERGY CORP COM 87807B107 31,638 753,871 SH   DFND 1 753,871 0 0
TC PIPELINES LP UT COM LTD PRT 87233Q108 2,164 84,604 SH   DFND 1 84,604 0 0
TELADOC HEALTH INC COM 87918A105 1,274,452 5,813,042 SH   DFND 1 5,547,768 0 265,274
TELADOC HEALTH INC COM 87918A105 31,680 144,501 SH   OTR 2 144,501 0 0
TELEFLEX INCORPORATED COM 879369106 48,491 142,444 SH   DFND 1 141,991 0 453
TERADYNE INC COM 880770102 1,457 18,338 SH   DFND 1 18,338 0 0
TESLA INC COM 88160R101 7,875,055 18,356,344 SH   DFND 1 17,630,400 0 725,944
TESLA INC COM 88160R101 166,059 387,074 SH   OTR 2 387,074 0 0
TEXAS INSTRS INC COM 882508104 159,592 1,117,672 SH   DFND 1 1,117,672 0 0
TFI INTL INC COM 87241L109 19,080 456,135 SH   DFND 1 456,135 0 0
TFI INTL INC COM 87241L109 2,923 69,875 SH   OTR 2 69,875 0 0
THE TRADE DESK INC COM CL A 88339J105 1,258,758 2,426,381 SH   DFND 1 2,298,282 0 128,099
THE TRADE DESK INC COM CL A 88339J105 36,522 70,400 SH   OTR 2 70,400 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 29,923 67,772 SH   DFND 1 67,772 0 0
THERMON GROUP HLDGS INC COM 88362T103 2,377 211,691 SH   DFND 1 211,691 0 0
THERMON GROUP HLDGS INC COM 88362T103 780 69,463 SH   OTR 2 69,463 0 0
TJX COS INC NEW COM 872540109 560 10,058 SH   DFND 1 10,058 0 0
TOLL BROTHERS INC COM 889478103 1,089 22,384 SH   DFND 1 22,384 0 0
TOTAL SE SPONSORED ADS 89151E109 22,793 664,526 SH   DFND 1 664,411 0 115
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 29,875 1,639,703 SH   DFND 1 1,639,703 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 5,273 289,392 SH   OTR 2 289,392 0 0
TPI COMPOSITES INC COM 87266J104 5,724 197,647 SH   DFND 1 197,579 0 68
TRACTOR SUPPLY CO COM 892356106 2,340 16,326 SH   DFND 1 16,326 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 42,323 349,059 SH   DFND 1 347,646 0 1,413
TREX CO INC COM 89531P105 16,448 229,724 SH   DFND 1 229,724 0 0
TREX CO INC COM 89531P105 4,030 56,282 SH   OTR 2 56,282 0 0
TRI POINTE GROUP INC COM 87265H109 1,577 86,960 SH   DFND 1 86,960 0 0
TRINET GROUP INC COM 896288107 1,982 33,419 SH   DFND 1 33,419 0 0
TRINITY INDS INC COM 896522109 13,534 694,053 SH   DFND 1 694,053 0 0
TRINITY INDS INC COM 896522109 3,973 203,751 SH   OTR 2 203,751 0 0
TRITON INTL LTD CL A G9078F107 589 14,486 SH   DFND 1 14,486 0 0
TRUIST FINL CORP COM 89832Q109 88,253 2,319,396 SH   DFND 1 2,319,396 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 52,703 603,292 SH   DFND 1 603,292 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 2,511 28,740 SH   OTR 2 28,740 0 0
TWILIO INC CL A 90138F102 1,769,242 7,160,315 SH   DFND 1 6,830,006 0 330,309
TWILIO INC CL A 90138F102 44,403 179,702 SH   OTR 2 179,702 0 0
TWIST BIOSCIENCE CORP COM 90184D100 12,480 164,280 SH   DFND 1 164,280 0 0
TWIST BIOSCIENCE CORP COM 90184D100 3,429 45,133 SH   OTR 2 45,133 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,234,957 33,852,975 SH   DFND 1 32,455,079 0 1,397,896
UBER TECHNOLOGIES INC COM 90353T100 14,469 396,628 SH   OTR 2 396,628 0 0
UFP INDUSTRIES INC COM 90278Q108 1,417 25,069 SH   DFND 1 25,069 0 0
UMB FINL CORP COM 902788108 607 12,390 SH   DFND 1 12,390 0 0
UNION PAC CORP COM 907818108 1,050,028 5,333,608 SH   DFND 1 5,172,679 0 160,929
UNION PAC CORP COM 907818108 12,597 63,988 SH   OTR 2 63,988 0 0
UNITED PARCEL SERVICE INC CL B 911312106 18,891 113,371 SH   DFND 1 113,371 0 0
UNITED RENTALS INC COM 911363109 73,448 420,907 SH   DFND 1 420,907 0 0
UNITEDHEALTH GROUP INC COM 91324P102 109,353 350,750 SH   DFND 1 350,750 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 11,104 61,438 SH   DFND 1 61,438 0 0
UTZ BRANDS INC COM CL A 918090101 8,173 456,593 SH   DFND 1 456,593 0 0
UTZ BRANDS INC COM CL A 918090101 2,458 137,310 SH   OTR 2 137,310 0 0
VALE S A SPONSORED ADS 91912E105 4,543 429,358 SH   DFND 1 429,199 0 159
VALERO ENERGY CORP COM 91913Y100 3,881 89,584 SH   DFND 1 89,549 0 35
VALLEY NATL BANCORP COM 919794107 2,040 297,881 SH   DFND 1 297,881 0 0
VANGUARD INDEX FDS GROWTH ETF 922908736 264 1,160 SH   DFND 1 1,160 0 0
VARONIS SYS INC COM 922280102 49,036 424,851 SH   DFND 1 424,851 0 0
VARONIS SYS INC COM 922280102 9,392 81,374 SH   OTR 2 81,374 0 0
VEEVA SYS INC CL A COM 922475108 3,054 10,860 SH   DFND 1 10,860 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 118,675 1,994,868 SH   DFND 1 1,994,868 0 0
VERTEX INC CL A 92538J106 11,674 507,572 SH   DFND 1 507,572 0 0
VERTEX INC CL A 92538J106 2,534 110,184 SH   OTR 2 110,184 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 972,365 3,573,294 SH   DFND 1 3,463,043 0 110,251
VERTEX PHARMACEUTICALS INC COM 92532F100 9,739 35,790 SH   OTR 2 35,790 0 0
VISA INC COM CL A 92826C839 2,878,554 14,394,930 SH   DFND 1 13,865,200 0 529,730
VISA INC COM CL A 92826C839 34,653 173,291 SH   OTR 2 173,291 0 0
VISHAY INTERTECHNOLOGY INC COM 928298108 664 42,646 SH   DFND 1 42,646 0 0
VITAL FARMS INC COM 92847W103 17,999 444,103 SH   DFND 1 444,103 0 0
VITAL FARMS INC COM 92847W103 2,983 73,590 SH   OTR 2 73,590 0 0
VROOM INC COM 92918V109 31,442 607,229 SH   DFND 1 607,229 0 0
VROOM INC COM 92918V109 5,041 97,357 SH   OTR 2 97,357 0 0
WABTEC COM 929740108 6,564 106,076 SH   DFND 1 106,076 0 0
WALMART INC COM 931142103 179,224 1,280,997 SH   DFND 1 1,280,997 0 0
WASTE CONNECTIONS INC COM 94106B101 9,933 95,693 SH   DFND 1 95,693 0 0
WAYFAIR INC CL A 94419L101 77,897 267,677 SH   DFND 1 251,803 0 15,874
WAYFAIR INC CL A 94419L101 5,546 19,059 SH   OTR 2 19,059 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 5,108 18,583 SH   DFND 1 18,583 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 6,221 126,776 SH   DFND 1 126,731 0 45
WILLIAMS COS INC COM 969457100 132,442 6,740,049 SH   DFND 1 6,740,049 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 54,864 3,289,224 SH   DFND 1 3,289,224 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 9,565 573,439 SH   OTR 2 573,439 0 0
WINGSTOP INC COM 974155103 33,740 246,910 SH   DFND 1 246,910 0 0
WINGSTOP INC COM 974155103 9,848 72,066 SH   OTR 2 72,066 0 0
WINTRUST FINL CORP COM 97650W108 25,386 633,866 SH   DFND 1 633,866 0 0
WINTRUST FINL CORP COM 97650W108 4,021 100,401 SH   OTR 2 100,401 0 0
WIX COM LTD SHS M98068105 66,396 260,530 SH   DFND 1 260,496 0 34
WORKDAY INC CL A 98138H101 925,066 4,300,031 SH   DFND 1 4,069,307 0 230,724
WORKDAY INC CL A 98138H101 11,773 54,726 SH   OTR 2 54,726 0 0
WPX ENERGY INC COM 98212B103 39,317 8,023,967 SH   DFND 1 8,023,530 0 437
WPX ENERGY INC COM 98212B103 4,902 1,000,351 SH   OTR 2 1,000,351 0 0
WSFS FINL CORP COM 929328102 16,540 613,266 SH   DFND 1 613,266 0 0
WSFS FINL CORP COM 929328102 3,112 115,405 SH   OTR 2 115,405 0 0
XCEL ENERGY INC COM 98389B100 58,397 846,215 SH   DFND 1 846,215 0 0
ZAI LAB LTD ADR 98887Q104 21,513 258,665 SH   DFND 1 258,665 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 110,640 812,694 SH   DFND 1 812,694 0 0
ZOETIS INC CL A 98978V103 236,976 1,433,003 SH   DFND 1 1,385,569 0 47,434
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 1,417 3,014 SH   DFND 1 3,014 0 0
ZUMIEZ INC COM 989817101 1,617 58,108 SH   DFND 1 58,108 0 0