The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 109,348 3,010,684 SH   SOLE   3,010,684 0 0
ADC THERAPEUTICS SA SHS H0036K147 258,666 5,525,870 SH   SOLE   5,525,870 0 0
AKERO THERAPEUTICS INC COM 00973Y108 9,772 392,152 SH   SOLE   392,152 0 0
ALLAKOS INC COM 01671P100 188,207 2,619,080 SH   SOLE   2,619,080 0 0
AMEDISYS INC COM 023436108 44,903 226,165 SH   SOLE   226,165 0 0
AMICUS THERAPEUTICS INC COM 03152W109 376,166 24,944,695 SH   SOLE   24,944,695 0 0
APREA THERAPEUTICS INC COM 03836J102 87,981 2,268,718 SH   SOLE   2,268,718 0 0
ARDELYX INC COM 039697107 24,318 3,514,100 SH   SOLE   3,514,100 0 0
ARGENX SE SPONSORED ADR 04016X101 233,083 1,034,868 SH   SOLE   1,034,868 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 99,708 6,843,370 SH   SOLE   6,843,370 0 0
ATRECA INC CL A COM 04965G109 21,111 992,068 SH   SOLE   992,068 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 41,855 1,192,100 SH   SOLE   1,192,100 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 6,687 666,666 SH   SOLE   666,666 0 0
BEAM THERAPEUTICS INC COM 07373V105 93,995 3,356,958 SH   SOLE   3,356,958 0 0
BIOGEN INC COM 09062X103 43,423 162,300 SH   SOLE   162,300 0 0
BIONTECH SE SPONSORED ADS 09075V102 204,836 3,069,164 SH   SOLE   3,069,164 0 0
BOSTON SCIENTIFIC CORP COM 101137107 31,506 897,355 SH   SOLE   897,355 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 8,832 2,467,000 SH   SOLE   2,467,000 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 3,617 133,931 SH   SOLE   133,931 0 0
CABALETTA BIO INC COM 12674W109 15,884 1,425,896 SH   SOLE   1,425,896 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 8 10,229 SH   SOLE   10,229 0 0
CATALENT INC COM 148806102 30,280 413,100 SH   SOLE   413,100 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 26,000 2,000,000 SH   SOLE   2,000,000 0 0
CIGNA CORP NEW COM 125523100 91,217 486,100 SH   SOLE   486,100 0 0
CRYOPORT INC COM PAR $0.001 229050307 54,984 1,817,663 SH   SOLE   1,817,663 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 5,844 1,674,447 SH   SOLE   1,674,447 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 297,342 4,978,941 SH   SOLE   4,978,941 0 0
DEXCOM INC COM 252131107 39,445 97,300 SH   SOLE   97,300 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 44,901 5,062,100 SH   SOLE   5,062,100 0 0
EIDOS THERAPEUTICS INC COM 28249H104 28,308 593,842 SH   SOLE   593,842 0 0
ENDOLOGIX INC COM NEW 29266S304 63 78,755 SH   SOLE   78,755 0 0
EPIZYME INC COM 29428V104 136,279 8,485,605 SH   SOLE   8,485,605 0 0
FATE THERAPEUTICS INC COM 31189P102 433,326 12,629,737 SH   SOLE   12,629,737 0 0
GENMAB A/S SPONSORED ADS 372303206 35,835 1,057,393 SH   SOLE   1,057,393 0 0
GENMARK DIAGNOSTICS INC COM 372309104 72,129 4,903,400 SH   SOLE   4,903,400 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 20,352 3,064,994 SH   SOLE   3,064,994 0 0
GUARDANT HEALTH INC COM 40131M109 24,146 297,619 SH   SOLE   297,619 0 0
HILL ROM HLDGS INC COM 431475102 64,221 585,000 SH   SOLE   585,000 0 0
HOOKIPA PHARMA INC COM 43906K100 21,620 1,860,610 SH   SOLE   1,860,610 0 0
ICU MED INC COM 44930G107 37,120 201,400 SH   SOLE   201,400 0 0
IGM BIOSCIENCES INC COM 449585108 229,512 3,144,000 SH   SOLE   3,144,000 0 0
IMMUNOGEN INC COM 45253H101 55,232 12,006,979 SH   SOLE   12,006,979 0 0
IMMUNOMEDICS INC COM 452907108 123,682 3,489,900 SH   SOLE   3,489,900 0 0
IMMUNOVANT INC COM 45258J102 14,610 600,000 SH   SOLE   600,000 0 0
INVITAE CORP COM 46185L103 13,058 431,100 SH   SOLE   431,100 0 0
ITAMAR MED LTD SPONSORED ADS 465437101 11,625 625,000 SH   SOLE   625,000 0 0
KRYSTAL BIOTECH INC COM 501147102 58,392 1,409,745 SH   SOLE   1,409,745 0 0
LUMINEX CORP DEL COM 55027E102 29,860 917,907 SH   SOLE   917,907 0 0
MERCK & CO. INC COM 58933Y105 40,544 524,300 SH   SOLE   524,300 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 156,546 4,705,308 SH   SOLE   4,705,308 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 67,084 4,041,211 SH   SOLE   4,041,211 0 0
NEVRO CORP COM 64157F103 59,468 497,764 SH   SOLE   497,764 0 0
NOVARTIS AG SPONSORED ADR 66987V109 38,412 439,800 SH   SOLE   439,800 0 0
ODONATE THERAPEUTICS INC COM 676079106 26,803 633,038 SH   SOLE   633,038 0 0
OVID THERAPEUTICS INC COM 690469101 899 121,950 SH   SOLE   121,950 0 0
PLIANT THERAPEUTICS INC COM 729139105 110,710 3,410,657 SH   SOLE   3,410,657 0 0
PPD INC COM 69355F102 51,817 1,933,473 SH   SOLE   1,933,473 0 0
PRA HEALTH SCIENCES INC COM 69354M108 27,177 279,336 SH   SOLE   279,336 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 162,174 2,712,388 SH   SOLE   2,712,388 0 0
PROFOUND MED CORP COM NEW 74319B502 6,776 400,000 SH   SOLE   400,000 0 0
REGENXBIO INC COM 75901B107 82,380 2,236,766 SH   SOLE   2,236,766 0 0
REPARE THERAPEUTICS INC COM 760273102 74,019 2,386,174 SH   SOLE   2,386,174 0 0
REPLIMUNE GROUP INC COM 76029N106 77,139 3,104,193 SH   SOLE   3,104,193 0 0
ROYALTY PHARMA PLC SHS CL A G7709Q104 9,710 200,000 SH   SOLE   200,000 0 0
SANOFI SPONSORED ADR 80105N105 62,562 1,225,500 SH   SOLE   1,225,500 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 52,370 2,875,889 SH   SOLE   2,875,889 0 0
SELECTQUOTE INC COM 816307300 12,586 496,872 SH   SOLE   496,872 0 0
STEREOTAXIS INC COM NEW 85916J409 13,841 3,103,327 SH   SOLE   3,103,327 0 0
STOKE THERAPEUTICS INC COM 86150R107 59,630 2,502,306 SH   SOLE   2,502,306 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 2,263 212,291 SH   SOLE   212,291 0 0
TCR2 THERAPEUTICS INC COM 87808K106 27,113 1,765,188 SH   SOLE   1,765,188 0 0
TRICIDA INC COM 89610F101 58,230 2,119,000 SH   SOLE   2,119,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 26,695 589,300 SH   SOLE   589,300 0 0
UNIQURE NV SHS N90064101 56,196 1,247,135 SH   SOLE   1,247,135 0 0
UNITEDHEALTH GROUP INC COM 91324P102 30,645 103,900 SH   SOLE   103,900 0 0
VAPOTHERM INC COM 922107107 1,025 25,000 SH   SOLE   25,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 4,322 415,155 SH   SOLE   415,155 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 6,377 2,397,441 SH   SOLE   2,397,441 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 79,771 1,661,205 SH   SOLE   1,661,205 0 0
ZYMEWORKS INC COM 98985W102 28,261 783,500 SH   SOLE   783,500 0 0