The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 57,162 600,000 SH   DFND 1 600,000 0 0
AGENUS INC COM NEW 00847G705 43,230 11,000,000 SH   DFND 1 11,000,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 14,766 592,539 SH   DFND 1 592,539 0 0
AKOUOS INC COM 00973J101 10,670 499,990 SH   DFND 1 499,990 0 0
ALLAKOS INC COM 01671P100 14,193 197,515 SH   DFND 1 197,515 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 4,152 600,000 SH   DFND 1 600,000 0 0
ANAPTYSBIO INC COM 032724106 19,790 885,838 SH   DFND 1 885,838 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 67,479 2,066,108 SH   DFND 1 2,066,108 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 37,392 800,000 SH   DFND 1 800,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,721 75,000 SH   DFND 1 75,000 0 0
ARGENX SE SPONSORED ADR 04016X101 15,766 70,000 SH   DFND 1 70,000 0 0
ARYA SCIENCES ACQUISITION CO UNIT 06/09/2027 G31655114 4,640 400,000 SH   DFND 1 400,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 25,883 175,000 SH   DFND 1 175,000 0 0
ATRECA INC CL A COM 04965G109 6,838 321,322 SH   DFND 1 321,322 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 7,694 479,988 SH   DFND 1 479,988 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 6,953 1,350,000 SH   DFND 1 1,350,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 67,804 2,514,547 SH   DFND 1 2,514,547 0 0
AVROBIO INC COM 05455M100 5,542 317,579 SH   DFND 1 317,579 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 25,293 720,397 SH   DFND 1 720,397 0 0
AXSOME THERAPEUTICS INC COM 05464T104 28,798 350,000 SH   DFND 1 350,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 22,036 796,429 SH   DFND 1 796,429 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 43,866 600,000 SH   DFND 1 600,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 11,680 175,000 SH   DFND 1 175,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 27,300 350,000 SH   DFND 1 350,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 84,485 2,590,762 SH   DFND 1 2,590,762 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 6,753 250,000 SH   DFND 1 250,000 0 0
CABALETTA BIO INC COM 12674W109 23,459 2,105,844 SH   DFND 1 2,105,844 0 0
CHEMOCENTRYX INC COM 16383L106 97,818 1,700,000 SH   DFND 1 1,700,000 0 0
CHEMOCENTRYX INC COM 16383L106 57,540 1,000,000 SH Call DFND 1 1,000,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 29,396 400,000 SH   DFND 1 400,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 19,046 318,914 SH   DFND 1 318,914 0 0
EIDOS THERAPEUTICS INC COM 28249H104 50,306 1,055,302 SH   DFND 1 1,055,302 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 6,720 700,000 SH   DFND 1 700,000 0 0
FATE THERAPEUTICS INC COM 31189P102 1,716 50,000 SH   DFND 1 50,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 152,547 3,379,373 SH   DFND 1 3,379,373 0 0
GALAPAGOS NV SPON ADR 36315X101 19,484 99,075 SH   DFND 1 99,075 0 0
GENETRON HLDGS LTD ADS 37186H100 6,035 500,000 SH   DFND 1 500,000 0 0
GOSSAMER BIO INC COM 38341P102 4,541 349,325 SH   DFND 1 349,325 0 0
HARPOON THERAPEUTICS INC COM 41358P106 10,711 645,257 SH   DFND 1 645,257 0 0
HOMOLOGY MEDICINES INC COM 438083107 8,355 550,000 SH   DFND 1 550,000 0 0
IGM BIOSCIENCES INC COM 449585108 24,831 340,146 SH   DFND 1 340,146 0 0
INSMED INC COM PAR $.01 457669307 12,393 450,000 SH   DFND 1 450,000 0 0
INSPIRE MED SYS INC COM 457730109 12,877 147,982 SH   DFND 1 147,982 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 71,590 500,000 SH Put DFND 1 500,000 0 0
KADMON HLDGS INC COM 48283N106 9,216 1,800,000 SH   DFND 1 1,800,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 6,734 1,300,000 SH   DFND 1 1,300,000 0 0
KURA ONCOLOGY INC COM 50127T109 11,410 700,000 SH   DFND 1 700,000 0 0
MERUS N V COM N5749R100 9,654 600,000 SH   DFND 1 600,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,849 512,159 SH   DFND 1 512,159 0 0
MIRATI THERAPEUTICS INC COM 60468T105 57,085 500,000 SH   DFND 1 500,000 0 0
MYOKARDIA INC COM 62857M105 57,972 600,000 SH   DFND 1 600,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 51,550 2,500,000 SH   DFND 1 2,500,000 0 0
NEKTAR THERAPEUTICS COM 640268108 2,895 125,000 SH   DFND 1 125,000 0 0
NEXTCURE INC COM 65343E108 14,879 693,971 SH   DFND 1 693,971 0 0
OMEROS CORP COM 682143102 40,848 2,775,000 SH   DFND 1 2,775,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,540 256,649 SH   DFND 1 256,649 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 117 416,666 SH   DFND 1 416,666 0 0
PLIANT THERAPEUTICS, INC COM 729139105 18,812 611,409 SH   DFND 1 611,409 0 0
PRECISION BIOSCIENCES INC COM 74019P108 2,887 346,524 SH   DFND 1 346,524 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 95,096 1,590,493 SH   DFND 1 1,590,493 0 0
QUOTIENT LTD SHS G73268107 21,463 2,900,399 SH   DFND 1 2,900,399 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 62,408 400,000 SH   DFND 1 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 10,944 352,795 SH   DFND 1 352,795 0 0
REVOLUTION MEDICINES INC COM 76155X100 82,737 2,636,661 SH   DFND 1 2,636,661 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 30,737 1,468,550 SH   DFND 1 1,468,550 0 0
SAREPTA THERAPEUTICS INC COM 803607100 17,637 110,000 SH   DFND 1 110,000 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 22,977 798,905 SH   DFND 1 798,905 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 40,820 6,500,000 SH   DFND 1 6,500,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 154,180 500,000 SH Put DFND 1 500,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 55,975 500,000 SH Put DFND 1 500,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 40,542 1,701,292 SH   DFND 1 1,701,292 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 2,099 100,000 SH   DFND 1 100,000 0 0
TRICIDA INC COM 89610F101 23,966 872,137 SH   DFND 1 872,137 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 176,802 2,737,297 SH   DFND 1 2,737,297 0 0
TWIST BIOSCIENCE CORP COM 90184D100 25,044 552,849 SH   DFND 1 552,849 0 0
UNIQURE NV SHS N90064101 20,014 444,157 SH   DFND 1 444,157 0 0
VIELA BIO INC COM 926613100 65,522 1,512,500 SH   DFND 1 1,512,500 0 0
X4 PHARMACEUTICALS INC -CW24 COM 98420X103 1,757 328,980 SH   DFND 1 328,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109 68,026 1,574,683 SH   DFND 1 1,574,683 0 0
ZAI LAB LTD ADR 98887Q104 20,533 250,000 SH   DFND 1 250,000 0 0
ZYMEWORKS INC COM 98985W102 19,839 550,000 SH   DFND 1 550,000 0 0