The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 4,128 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
21VIANET GROUP INC SPONSORED ADS 90138A103 13,910 583,000 SH   DFND 1,2,3,4,5,6 583,000 0 0
ABBVIE INC COM 00287Y109 24,545 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
AC IMMUNE SA SHS H00263105 6,626 984,550 SH   DFND 1,2,3,4,5,6 984,550 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 8,891 586,500 SH   DFND 1,2,3,4,5,6 586,500 0 0
ACCELERON PHARMA INC COM 00434H108 133,378 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 9,095 188,000 SH   DFND 1,2,3,4,5,6 188,000 0 0
ADC THERAPEUTICS SA SHS H0036K147 6,366 136,000 SH   DFND 1,2,3,4,5,6 136,000 0 0
ADURO BIOTECH INC COM 00739L101 2,195 950,000 SH   DFND 1,2,3,4,5,6 950,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 18,792 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 10,175 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
AGENUS INC COM NEW 00847G705 11,201 2,850,000 SH   DFND 1,2,3,4,5,6 2,850,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 20,108 376,000 SH   DFND 1,2,3,4,5,6 376,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 7,795 574,000 SH   DFND 1,2,3,4,5,6 574,000 0 0
ALBIREO PHARMA INC COM 01345P106 13,255 500,360 SH   DFND 1,2,3,4,5,6 500,360 0 0
ALECTOR INC COM 014442107 4,888 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 56,120 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 80,348 372,500 SH   DFND 1,2,3,4,5,6 372,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 133,299 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 14,811 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 19,605 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 6,535 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 52,780 3,500,000 SH   DFND 1,2,3,4,5,6 3,500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 15,080 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
APTINYX INC COM 03836N103 6,593 1,581,090 SH   DFND 1,2,3,4,5,6 1,581,090 0 0
ARAVIVE INC COM 03890D108 16,067 1,380,306 SH   DFND 1,2,3,4,5,6 1,380,306 0 0
ARGENX SE SPONSORED ADR 04016X101 101,354 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 9,614 65,000 SH   DFND 1,2,3,4,5,6 65,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 36,425 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 14,625 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 6,412 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AVANTOR INC COM 05352A100 34,000 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 4,946 175,000 SH   DFND 1,2,3,4,5,6 175,000 0 0
AXCELLA HEALTH INC COM 05454B105 4,977 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
BK OF AMERICA CORP COM 060505104 23,750 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 160,140 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 1,479 143,763 SH   DFND 1,2,3,4,5,6 143,763 0 0
BIONTECH SE SPONSORED ADS 09075V102 133,480 2,000,000 SH   DFND 1,2,3,4 2,000,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 10,011 150,000 SH Call DFND 1,2,3,4,5,6 150,000 0 0
BIO-TECHNE CORP COM 09073M104 17,165 65,000 SH   DFND 1,2,3,4,5,6 65,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 65,201 1,546,517 SH   DFND 1,2,3,4,5,6 1,546,517 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 42,900 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 19,566 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BRUKER CORP COM 116794108 7,505 184,500 SH   DFND 1,2,3,4,5,6 184,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 873 236,500 SH   DFND 1,2,3,4,5,6 236,500 0 0
CITIGROUP INC COM NEW 172967424 51,100 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,375 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
CRYOPORT INC COM PAR $0.001 229050307 2,692 89,000 SH   DFND 1,2,3,4,5,6 89,000 0 0
CURIS INC COM NEW 231269200 1,789 1,478,662 SH   DFND 1,2,3,4,5,6 1,478,662 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 65 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 10,818 1,830,531 SH   DFND 1,2,3,4,5,6 1,830,531 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,566 188,000 SH   DFND 1,2,3,4,5,6 188,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 38,818 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 35,063 1,250,000 SH Call DFND 1,2,3,4,5,6 1,250,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 10,881 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
EPIZYME INC COM 29428V104 30,113 1,875,000 SH   DFND 1,2,3,4,5,6 1,875,000 0 0
EPIZYME INC COM 29428V104 16,060 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
EVELO BIOSCIENCES INC COM 299734103 3,267 666,666 SH   DFND 1,2,3,4,5,6 666,666 0 0
FATE THERAPEUTICS INC COM 31189P102 61,758 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
FIBROGEN INC COM 31572Q808 16,212 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 87,626 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
GENERAL MTRS CO COM 37045V100 12,650 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
GENERATION BIO CO COM 37148K100 59,098 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 39,524 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
GOSSAMER BIO INC COM 38341P102 34,567 2,658,968 SH   DFND 1,2,3,4,5,6 2,658,968 0 0
HARPOON THERAPEUTICS INC COM 41358P106 14,940 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
HOOKIPA PHARMA INC COM 43906K100 6,968 599,616 SH   DFND 1,2,3,4,5,6 599,616 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 6,134 175,000 SH   DFND 1,2,3,4,5,6 175,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 3,401 239,304 SH   DFND 1,2,3,4,5,6 239,304 0 0
I MAB SPONSORED ADS 44975P103 9,697 324,000 SH   DFND 1,2,3,4,5,6 324,000 0 0
IMMUNIC INC COM 4525EP101 7,272 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
IMMUNOMEDICS INC COM 452907108 8,181 230,838 SH   DFND 1,2,3,4,5,6 230,838 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 5,024 239,000 SH   DFND 1,2,3,4,5,6 239,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 13,725 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,141 110,532 SH   DFND 1,2,3,4 110,532 0 0
JPMORGAN CHASE & CO COM 46625H100 282,180 3,000,000 SH Call DFND 1,2,3,4,5,6 3,000,000 0 0
KALEIDO BIOSCIENCES INC COM 483347100 3,719 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KRYSTAL BIOTECH INC COM 501147102 8,284 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
KURA ONCOLOGY INC COM 50127T109 9,421 578,000 SH   DFND 1,2,3,4,5,6 578,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 6,216 2,974,000 SH   DFND 1,2,3,4,5,6 2,974,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 7,015 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 113,166 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,380 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,949 714,000 SH   DFND 1,2,3,4,5,6 714,000 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 7,760 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 18,720 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
MERUS N V COM N5749R100 6,179 384,000 SH   DFND 1,2,3,4,5,6 384,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,888 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
MODERNA INC COM 60770K107 32,105 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 45,151 1,669,186 SH   DFND 1,2,3,4,5,6 1,669,186 0 0
NEKTAR THERAPEUTICS COM 640268108 5,535 239,000 SH   DFND 1,2,3,4,5,6 239,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 23,868 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,220 370,000 SH   DFND 1,2,3,4,5,6 370,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 5,060 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
PASSAGE BIO INC COM 702712100 6,395 234,000 SH   DFND 1,2,3,4,5,6 234,000 0 0
PAYPAL HLDGS INC COM 70450Y103 34,846 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 5,513 370,000 SH   DFND 1,2,3,4,5,6 370,000 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 11,958 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 7,656 1,259,177 SH   DFND 1,2,3,4,5,6 1,259,177 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 2,472 140,000 SH   DFND 1,2,3,4,5,6 140,000 0 0
PROTHENA CORP PLC SHS G72800108 3,870 370,000 SH   DFND 1,2,3,4,5,6 370,000 0 0
REGENXBIO INC COM 75901B107 8,618 234,000 SH   DFND 1,2,3,4,5,6 234,000 0 0
REPARE THERAPEUTICS INC COM 760273102 18,612 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
REPLIMUNE GROUP INC COM 76029N106 18,638 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
RESTORBIO INC COM 76133L103 2,049 953,000 SH   DFND 1,2,3,4,5,6 953,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 619 338,000 SH   DFND 1,2,3,4,5,6 338,000 0 0
ROYALTY PHARMA PLC SHS CL A G7709Q104 36,413 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 23,037 3,852,341 SH   DFND 1,2,3,4,5,6 3,852,341 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,730 234,000 SH   DFND 1,2,3,4,5,6 234,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 45,963 2,524,040 SH   DFND 1,2,3,4,5,6 2,524,040 0 0
SCHRODINGER INC COM 80810D103 82,179 897,445 SH   DFND 1,2,3,4,5,6 897,445 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 1,893 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 30,915 450,000 SH Call DFND 1,2,3,4,5,6 450,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 8,236 2,900,000 SH   DFND 1,2,3,4,5,6 2,900,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 5,274 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 7,374 545,040 SH   DFND 1,2,3,4,5,6 545,040 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 12,600 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 6,792 285,000 SH   DFND 1,2,3,4,5,6 285,000 0 0
STONECO LTD COM CL A G85158106 11,240 290,000 SH   DFND 1,2,3,4,5,6 290,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 5,223 490,000 SH   DFND 1,2,3,4,5,6 490,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 5,677 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 5,376 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
TG THERAPEUTICS INC COM 88322Q108 34,090 1,750,000 SH   DFND 1,2,3,4,5,6 1,750,000 0 0
TRANSLATE BIO INC COM 89374L104 28,672 1,600,000 SH   DFND 1,2,3,4,5,6 1,600,000 0 0
TRICIDA INC COM 89610F101 7,832 285,000 SH   DFND 1,2,3,4,5,6 285,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 7,710 953,000 SH   DFND 1,2,3,4,5,6 953,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 15,552 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 22,607 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
UNIQURE NV SHS N90064101 45,060 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
VAXART INC COM NEW 92243A200 1,770 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
WW INTL INC COM 98262P101 376,088 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 12,961 300,030 SH   DFND 1,2,3,4,5,6 300,030 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 4,418 92,000 SH   DFND 1,2,3,4,5,6 92,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 27,826 483,000 SH   DFND 1,2,3,4,5,6 483,000 0 0