The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AC IMMUNE SA | SHS | H00263105 | 76,175 | 11,318,758 | SH | DFND | 1 | 0 | 11,318,758 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 28,917 | 1,294,401 | SH | DFND | 1 | 0 | 1,294,401 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 46,579 | 1,882,722 | SH | DFND | 1 | 0 | 1,882,722 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 87,840 | 390,000 | SH | DFND | 1 | 0 | 390,000 | 0 | |
| BIOLINERX LTD | SPONSORED ADS | 09071M205 | 2,884 | 1,686,375 | SH | DFND | 1 | 0 | 1,686,375 | 0 | |
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 15,970 | 378,788 | SH | DFND | 1 | 0 | 378,788 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 37,439 | 7,090,638 | SH | DFND | 1 | 0 | 7,090,638 | 0 | |
| CALLIDITAS THERAPEUTICS AB | SPONSORED ADS | 13124Q106 | 17,475 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 35,620 | 2,740,000 | SH | DFND | 1 | 0 | 2,740,000 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 13,613 | 3,689,203 | SH | DFND | 1 | 0 | 3,689,203 | 0 | |
| CONTRAFECT CORP | COM | 212326300 | 10,224 | 1,600,000 | SH | DFND | 1 | 0 | 1,600,000 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 4,739 | 1,742,112 | SH | DFND | 1 | 0 | 1,742,112 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 8,038 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CURIS INC | COM NEW | 231269200 | 4,417 | 3,650,000 | SH | DFND | 1 | 0 | 3,650,000 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 25,952 | 3,115,537 | SH | DFND | 1 | 0 | 3,115,537 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 5,263 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 12,306 | 1,984,889 | SH | DFND | 1 | 0 | 1,984,889 | 0 | |
| EVELO BIOSCIENCES INC | COM | 299734103 | 6,370 | 1,300,000 | SH | DFND | 1 | 0 | 1,300,000 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 363 | 15,300 | SH | DFND | 1 | 0 | 15,300 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 48,727 | 7,988,053 | SH | DFND | 1 | 0 | 7,988,053 | 0 | |
| FORTE BIOSCIENCES INC | COM | 34962G109 | 14,272 | 978,857 | SH | DFND | 1 | 0 | 978,857 | 0 | |
| FORWARD PHARMA A/S | SPONSORD ADS NEW | 34986J204 | 3,968 | 647,299 | SH | DFND | 1 | 0 | 647,299 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 8,603 | 1,799,694 | SH | DFND | 1 | 0 | 1,799,694 | 0 | |
| GAMIDA CELL LTD | SHS | M47364100 | 9,797 | 2,143,667 | SH | DFND | 1 | 0 | 2,143,667 | 0 | |
| GENOCEA BIOSCIENCES INC | COM NEW | 372427401 | 4,642 | 2,018,398 | SH | DFND | 1 | 0 | 2,018,398 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 27,238 | 7,244,262 | SH | DFND | 1 | 0 | 7,244,262 | 0 | |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 45,852 | 3,226,769 | SH | DFND | 1 | 0 | 3,226,769 | 0 | |
| IMMUNOVANT INC | COM | 45258J102 | 26,504 | 1,088,479 | SH | DFND | 1 | 0 | 1,088,479 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 15,764 | 17,426,968 | SH | DFND | 1 | 0 | 17,426,968 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 83,891 | 1,422,842 | SH | DFND | 1 | 0 | 1,422,842 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 45,247 | 2,775,882 | SH | DFND | 1 | 0 | 2,775,882 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 17,058 | 4,130,162 | SH | DFND | 1 | 0 | 4,130,162 | 0 | |
| MERUS N V | COM | N5749R100 | 81,907 | 5,090,571 | SH | DFND | 1 | 0 | 5,090,571 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 29,635 | 2,149,057 | SH | DFND | 1 | 0 | 2,149,057 | 0 | |
| NOVUS THERAPEUTICS INC | COM | 67011N105 | 818 | 1,785,000 | SH | DFND | 1 | 0 | 1,785,000 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 17,630 | 2,392,151 | SH | DFND | 1 | 0 | 2,392,151 | 0 | |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 10,600 | 322,098 | SH | DFND | 1 | 0 | 322,098 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 9,658 | 3,115,382 | SH | DFND | 1 | 0 | 3,115,382 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 88,769 | 1,484,674 | SH | DFND | 1 | 0 | 1,484,674 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 41,806 | 2,367,288 | SH | DFND | 1 | 0 | 2,367,288 | 0 | |
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 988 | 1,450,000 | SH | DFND | 1 | 0 | 1,450,000 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 60,320 | 1,944,546 | SH | DFND | 1 | 0 | 1,944,546 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 57,529 | 2,315,053 | SH | DFND | 1 | 0 | 2,315,053 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 25,202 | 798,286 | SH | DFND | 1 | 0 | 798,286 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 23,557 | 8,294,547 | SH | DFND | 1 | 0 | 8,294,547 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 6,583 | 486,540 | SH | DFND | 1 | 0 | 486,540 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 1,384 | 941,171 | SH | DFND | 1 | 0 | 941,171 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 96,049 | 2,286,891 | SH | DFND | 1 | 0 | 2,286,891 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM | 867328700 | 684 | 2,594,925 | SH | DFND | 1 | 0 | 2,594,925 | 0 | |
| SURFACE ONCOLOGY INC | COM | 86877M209 | 13,373 | 2,038,528 | SH | DFND | 1 | 0 | 2,038,528 | 0 | |
| SUTRO BIOPHARMA INC | COM | 869367102 | 18,379 | 2,368,392 | SH | DFND | 1 | 0 | 2,368,392 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 36,615 | 2,470,678 | SH | DFND | 1 | 0 | 2,470,678 | 0 | |
| VERASTEM INC | COM | 92337C104 | 8,650 | 5,028,994 | SH | DFND | 1 | 0 | 5,028,994 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 9,422 | 1,010,892 | SH | DFND | 1 | 0 | 1,010,892 | 0 | |
| XENCOR INC | COM | 98401F105 | 66,986 | 2,068,098 | SH | DFND | 1 | 0 | 2,068,098 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 44,101 | 3,516,851 | SH | DFND | 1 | 0 | 3,516,851 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 79,557 | 4,026,157 | SH | DFND | 1 | 0 | 4,026,157 | 0 | |