The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 408 20,478 SH   SOLE 20,478 0 0
ACCURAY INC COM 004397105 1,369 674,300 SH   SOLE 674,300 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 4,125 279,440 SH   SOLE 279,440 0 0
AFFIMED NV COM N01045108 3,900 845,000 SH   SOLE 845,000 0 0
AILERON THERAPEUTICS INC COM 00887A105 531 450,000 SH   SOLE 450,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 10,357 762,666 SH   SOLE 762,666 0 0
ALECTOR INC COM 014442107 3,422 140,000 SH   SOLE 140,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,096 33,554 SH   SOLE 33,554 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 6,431 1,160,878 SH   SOLE 1,160,878 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 6,965 149,017 SH   SOLE 149,017 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,784 72,100 SH   SOLE 72,100 0 0
ARDELYX INC COM 039697107 1,279 184,850 SH   SOLE 184,850 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 15,432 245,142 SH   SOLE 245,142 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,106 14,237 SH   SOLE 14,237 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 172 86,082 SH   SOLE 86,082 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 830 35,573 SH   SOLE 35,573 0 0
ATRICURE INC COM 04963C209 5,989 133,229 SH   SOLE 133,229 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,030 64,235 SH   SOLE 64,235 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 2,835 1,005,391 SH   SOLE 1,005,391 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 3,545 744,051 SH   SOLE 744,051 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 6,404 87,600 SH   SOLE 87,600 0 0
BIOTELEMETRY INC COM 090672106 2,734 60,500 SH   SOLE 60,500 0 0
BLUEBIRD BIO INC COM 09609G100 1,848 30,273 SH   SOLE 30,273 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 17,791 228,089 SH   SOLE 228,089 0 0
CARA THERAPEUTICS INC COM 140755109 6,345 371,033 SH   SOLE 371,033 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 4,770 151,200 SH   SOLE 151,200 0 0
CERECOR INC COM 15671L109 827 318,000 SH   SOLE 318,000 0 0
COMPUGEN LTD ORD M25722105 5,153 343,046 SH   SOLE 343,046 0 0
CONSTELLATION PHARMACEUTICAL COM 210373106 5,137 170,942 SH   SOLE 170,942 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 907 108,061 SH   SOLE 108,061 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 578 165,600 SH   SOLE 165,600 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 51 6,100 SH   SOLE 6,100 0 0
DEXCOM INC COM 252131107 8,569 21,138 SH   SOLE 21,138 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 11,538 454,236 SH   SOLE 454,236 0 0
FATE THERAPEUTICS INC COM 31189P102 16,841 490,861 SH   SOLE 490,861 0 0
GALAPAGOS NV SPON ADR 36315X101 8,755 44,375 SH   SOLE 44,375 0 0
GAMIDA CELL LTD SHS M47364100 640 140,000 SH   SOLE 140,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,207 524,664 SH   SOLE 524,664 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 332 50,000 SH   SOLE 50,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 1,413 85,119 SH   SOLE 85,119 0 0
HOOKIPA PHARMA INC COM 43906K100 931 80,118 SH   SOLE 80,118 0 0
IMMUNOMEDICS INC COM 452907108 8,892 250,905 SH   SOLE 250,905 0 0
INOGEN INC COM 45780L104 533 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 7,504 54,900 SH   SOLE 54,900 0 0
IVERIC BIO INC COM 46583P102 1,823 357,500 SH   SOLE 357,500 0 0
JOHNSON AND JOHNSON COM 478160104 1,322 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 2,834 553,564 SH   SOLE 553,564 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,692 222,452 SH   SOLE 222,452 0 0
KARUNA THERAPEUTICS INC COM 48576A100 1,029 9,231 SH   SOLE 9,231 0 0
KURA ONCOLOGY INC COM 50127T109 4,796 294,260 SH   SOLE 294,260 0 0
LARIMAR THERAPEUTICS INC COM 517125100 1,622 126,261 SH   SOLE 126,261 0 0
LEAP THERAPEUTICS INC COM 52187K101 575 275,000 SH   SOLE 275,000 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 83 95,000 SH   SOLE 95,000 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 4,631 550,000 SH   SOLE 550,000 0 0
LUMINEX CORP COM 55027E102 5,013 154,091 SH   SOLE 154,091 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 747 6,600 SH   SOLE 6,600 0 0
MASIMO CORPORATION COM 574795100 684 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 227 55,000 SH   SOLE 55,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 235 76,800 SH   SOLE 76,800 0 0
MERSANA THERAPEUTICS INC COM 59045L106 6,322 270,163 SH   SOLE 270,163 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,500 21,893 SH   SOLE 21,893 0 0
MORPHIC HOLDING INC COM 61775R105 812 30,000 SH   SOLE 30,000 0 0
NATUS MEDICAL INC COM 639050103 936 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,931 73,208 SH   SOLE 73,208 0 0
NEURONETICS INC COM 64131A105 957 495,772 SH   SOLE 495,772 0 0
NEXTCURE INC COM 65343E108 429 20,000 SH   SOLE 20,000 0 0
OTONOMY INC COM 68906L105 1,698 469,135 SH   SOLE 469,135 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 1,474 320,542 SH   SOLE 320,542 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 1,118 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 7,523 1,237,400 SH   SOLE 1,237,400 0 0
PROVENTION BIO INC COM 74374N102 353 25,000 SH   SOLE 25,000 0 0
RADIUS HEALTH INC COM NEW 750469207 300 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 2,990 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 289 157,700 SH   SOLE 157,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 6,873 165,306 SH   SOLE 165,306 0 0
SCPHARMACEUTICALS INC COM 810648105 736 100,000 SH   SOLE 100,000 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 827 372,500 SH   SOLE 372,500 0 0
STEREOTAXIS INC COM NEW 85916J409 61,015 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 826 106,444 SH   SOLE 106,444 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,335 360,000 SH   SOLE 360,000 0 0
SYNLOGIC INC COM 87166L100 819 403,597 SH   SOLE 403,597 0 0
TCR2 THERAPEUTICS INC COM 87808K106 709 46,183 SH   SOLE 46,183 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,499 23,210 SH   SOLE 23,210 0 0
VIKING THERAPEUTICS INC COM 92686J106 3,251 450,900 SH   SOLE 450,900 0 0
XENON PHARMACEUTICALS INC COM 98420N105 4,346 346,535 SH   SOLE 346,535 0 0
ZOGENIX INC COM NEW 98978L204 1,371 50,749 SH   SOLE 50,749 0 0
ZYMEWORKS INC COM 98985W102 651 18,039 SH   SOLE 18,039 0 0