The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 24,508 257,249 SH   DFND 1,2,3,4 257,249 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 17,186 1,164,343 SH   DFND 1,2,3,4 1,164,343 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 15,209 135,500 SH   DFND 1,2,3,4 135,500 0 0
ALPHABET INC CAP STK CL A 02079K305 27,924 19,692 SH   DFND 1,2,3,4 19,692 0 0
AMAZON COM INC COM 023135106 37,319 13,527 SH   DFND 1,2,3,4 13,527 0 0
API GROUP CORP COM STK 00187Y100 18,752 1,543,344 SH   DFND 1,2,3,4 1,543,344 0 0
ATHENEX INC COM 04685N103 51,132 3,715,960 SH   DFND 1,2,3,4 3,715,960 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 3,250 200,000 SH Call DFND 1,2,3,4 200,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 21,951 1,350,808 SH   DFND 1,2,3,4 1,350,808 0 0
AXON ENTERPRISE INC COM 05464C101 7,850 80,000 SH   DFND 1,2,3,4 80,000 0 0
AZEK CO INC CL A 05478C105 637 20,000 SH   DFND 1,2,3,4 20,000 0 0
BEYOND AIR INC COM 08862L103 3,705 511,036 SH   DFND 1,2,3,4 511,036 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,311 100,000 SH Call DFND 1,2,3,4 100,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 95,208 1,302,261 SH   DFND 1,2,3,4 1,302,261 0 0
CARA THERAPEUTICS INC COM 140755109 10,715 626,583 SH   DFND 1,2,3,4 626,583 0 0
CONSTELLIUM SE CL A SHS F21107101 17,752 2,311,416 SH   DFND 1,2,3,4 2,311,416 0 0
CROWN HLDGS INC COM 228368106 36,392 558,762 SH   DFND 1,2,3,4 558,762 0 0
DANAHER CORPORATION COM 235851102 8,187 46,300 SH   DFND 1,2,3,4 46,300 0 0
DISNEY WALT CO COM DISNEY 254687106 14,976 134,300 SH   DFND 1,2,3,4 134,300 0 0
EXICURE INC COM 30205M101 828 339,395 SH   DFND 1,2,3,4 339,395 0 0
FACEBOOK INC CL A 30303M102 8,107 35,703 SH   DFND 1,2,3,4 35,703 0 0
FLEXION THERAPEUTICS INC COM 33938J106 15,384 1,169,895 SH   DFND 1,2,3,4 1,169,895 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,637 711,552 SH   DFND 1,2,3,4 711,552 0 0
GRAF INDL CORP COM 384278107 2,596 186,750 SH   DFND 1,2,3,4 186,750 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 2,934 1,259,049 SH   DFND 1,2,3,4 1,259,049 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 4,830 1,159,600 SH   DFND 1,2,3,4 1,159,600 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 99,411 401,500 SH Put DFND 1,2,3,4 401,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 4,118 150,000 SH Put DFND 1,2,3,4 150,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 101,658 710,000 SH Put DFND 1,2,3,4 710,000 0 0
JD.COM INC SPON ADR CL A 47215P106 12,355 205,300 SH   DFND 1,2,3,4 205,300 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 19,217 128,725 SH   DFND 1,2,3,4 128,725 0 0
LEXINFINTECH HLDGS LTD ADR 528877103 12,236 1,150,000 SH   DFND 1,2,3,4 1,150,000 0 0
MIMECAST LTD ORD SHS G14838109 16,636 399,324 SH   DFND 1,2,3,4 399,324 0 0
MOLECULAR TEMPLATES INC COM 608550109 6,585 477,536 SH   DFND 1,2,3,4 477,536 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 13,251 617,749 SH   DFND 1,2,3,4 617,749 0 0
PTC THERAPEUTICS INC COM 69366J200 12,773 251,734 SH   DFND 1,2,3,4 251,734 0 0
PURPLE INNOVATION INC COM 74640Y106 15,930 885,000 SH   DFND 1,2,3,4 885,000 0 0
SCYNEXIS INC COM 811292101 2,005 2,670,487 SH   DFND 1,2,3,4 2,670,487 0 0
SEA LTD SPONSORED ADS 81141R100 6,434 60,000 SH Put DFND 1,2,3,4 60,000 0 0
SEA LTD SPONSORED ADS 81141R100 24,837 231,600 SH   DFND 1,2,3,4 231,600 0 0
SELECT SECTOR SPDR TR COMMUNICATION 81369Y852 5,404 100,000 SH Put DFND 1,2,3,4 100,000 0 0
SESEN BIO INC COM 817763105 1,259 1,749,219 SH   DFND 1,2,3,4 1,749,219 0 0
SIMPLY GOOD FOODS CO COM 82900L102 7,492 403,229 SH   DFND 1,2,3,4 403,229 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 7,427 829,500 SH   DFND 1,2,3,4 829,500 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 164,973 535,000 SH Put DFND 1,2,3,4 535,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 16,793 150,000 SH Put DFND 1,2,3,4 150,000 0 0
SPLUNK INC COM 848637104 14,445 72,700 SH   DFND 1,2,3,4 72,700 0 0
STONERIDGE INC COM 86183P102 8,167 395,301 SH   DFND 1,2,3,4 395,301 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 13,141 192,173 SH   DFND 1,2,3,4 192,173 0 0
TRILOGY METALS INC NEW COM 89621C105 3,047 1,523,461 SH   DFND 1,2,3,4 1,523,461 0 0
VERTIV HOLDINGS CO COM CL A 92537N108 23,433 1,728,087 SH   DFND 1,2,3,4 1,728,087 0 0
WILLSCOT CORP COM 971375126 9,727 791,431 SH   DFND 1,2,3,4 791,431 0 0
WNS HLDGS LTD SPON ADR 92932M101 4,948 90,000 SH   DFND 1,2,3,4 90,000 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 15,212 60,000 SH Put DFND 1,2,3,4 60,000 0 0