The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 11,921 807,656 SH   SOLE   807,656 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 26,990 1,987,506 SH   SOLE   1,987,506 0 0
AKOUOS INC COM 00973J101 10,525 467,786 SH   SOLE   467,786 0 0
AMICUS THERAPEUTICS INC COM 03152W109 34,986 2,320,026 SH   SOLE   2,320,026 0 0
APPLE INC COM 037833100 137,977 378,226 SH   SOLE   378,226 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 6,185 84,600 SH   SOLE   84,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 20,028 256,767 SH   SOLE   256,767 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 101,034 3,070,957 SH   SOLE   3,070,957 0 0
CABLE ONE INC COM 12685J105 101,683 57,291 SH   SOLE   57,291 0 0
CATALENT INC COM 148806102 60,453 824,739 SH   SOLE   824,739 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 13,136 437,131 SH   SOLE   437,131 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 7,963 2,927,560 SH   SOLE   2,927,560 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 3,757 214,453 SH   SOLE   214,453 0 0
ENTASIS THERAPEUTICS HLDGS I COM 293614103 6,458 2,181,843 SH   SOLE   2,181,843 0 0
FLEXION THERAPEUTICS INC COM 33938J106 18,454 1,403,370 SH   SOLE   1,403,370 0 0
GALERA THERAPEUTICS INC COM 36338D108 24,340 3,409,021 SH   SOLE   3,409,021 0 0
INARI MED INC COM 45332Y109 3,657 75,500 SH   SOLE   75,500 0 0
INOGEN INC COM 45780L104 126,072 3,549,321 SH   SOLE   3,549,321 0 0
INSPIRE MED SYS INC COM 457730109 6,921 79,536 SH   SOLE   79,536 0 0
INSMED INC COM PAR $.01 457669307 11,845 430,107 SH   SOLE   430,107 0 0
INTERSECT ENT INC COM 46071F103 7,562 558,515 SH   SOLE   558,515 0 0
MEDTRONIC PLC SHS G5960L103 90,612 988,136 SH   SOLE   988,136 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 7,865 2,080,585 SH   SOLE   2,080,585 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 47,583 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 71,559 2,645,446 SH   SOLE   2,645,446 0 0
NEURONETICS INC COM 64131A105 992 514,190 SH   SOLE   514,190 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 14,555 824,169 SH   SOLE   824,169 0 0
SEASPINE HLDGS CORP COM 81255T108 18,746 1,790,431 SH   SOLE   1,790,431 0 0
SI BONE INC COM 825704109 15,778 989,827 SH   SOLE   989,827 0 0
SILK RD MED INC COM 82710M100 6,092 145,428 SH   SOLE   145,428 0 0
SPERO THERAPEUTICS INC COM 84833T103 12,598 931,099 SH   SOLE   931,099 0 0
VAXCYTE INC COM 92243G108 27,877 881,898 SH   SOLE   881,898 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 480,610 3,070,400 SH   SOLE   3,070,400 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,467 740,740 SH   SOLE   740,740 0 0
ZOGENIX INC COM NEW 98978L204 8,800 325,814 SH   SOLE   325,814 0 0