The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 3,097 1,911,573 SH   SOLE   1,911,573 0 0
Akouos, Inc ADR 00973J101 34,089 1,515,073 SH   SOLE   1,515,073 0 0
Amarin ADR 023111206 36,041 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc COMM 03753U106 1,619 49,580 SH   SOLE   49,580 0 0
Ascendis Pharma A/S ADR 04351P101 164,150 1,109,874 SH   SOLE   1,109,874 0 0
Chiasma COMM 16706W102 8,771 1,630,221 SH   SOLE   1,630,221 0 0
Coherus BioSciences COMM 19249H103 34,527 1,933,221 SH   SOLE   1,933,221 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 3,493 1,180,178 SH   SOLE   1,180,178 0 0
Galera Therapeutics, Inc COMM 36338D108 22,018 3,083,712 SH   SOLE   3,083,712 0 0
Karuna Therapeutics, Inc. COMM 48576A100 210,169 1,885,602 SH   SOLE   1,885,602 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 20,634 809,803 SH   SOLE   809,803 0 0
Merus N.V. COMM N5749R100 21,095 1,311,039 SH   SOLE   1,311,039 0 0
Natera COMM 632307104 154,594 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 57,285 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 12,263 2,266,666 SH   SOLE   2,266,666 0 0
Nucana Biomed Ltd Ordinary Shares GBOOBYWYV 12,984 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 27,975 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 287 142,635 SH   SOLE   142,635 0 0
Principia Biopharma COMM 74257L108 84,738 1,417,258 SH   SOLE   1,417,258 0 0
Synlogic Inc. COMM 87166L100 1,167 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 94,793 2,194,278 SH   SOLE   2,194,278 0 0
Abbvie Inc COMM 00287Y109 10,772 109,717 SH   SOLE   109,717 0 0
Acceleron Pharma Inc COMM 00434H108 9,016 94,641 SH   SOLE   94,641 0 0
Akebia Therapeutics Inc COMM 00972D105 4,032 296,912 SH   SOLE   296,912 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 9,672 65,300 SH Call SOLE   65,300 0 0
Amgen Inc COMM 031162950 17,336 73,500 SH Put SOLE   73,500 0 0
Applied Genetic Technologies Corp COMM 03820J100 2,582 466,103 SH   SOLE   466,103 0 0
Arena Pharmaceuticals Inc COMM 040047607 382 6,065 SH   SOLE   6,065 0 0
Axsome Therapeutics Inc COMM 05464T104 3,116 37,871 SH   SOLE   37,871 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 2,821 592,106 SH   SOLE   592,106 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 3,378 27,390 SH   SOLE   27,390 0 0
Blueprint Medicines Corp COMM 09627Y109 3,231 41,427 SH   SOLE   41,427 0 0
Calithera Biosciences Inc COMM 13089P101 2,092 396,177 SH   SOLE   396,177 0 0
ChemoCentryx Inc COMM 16383L106 2,428 42,192 SH   SOLE   42,192 0 0
Compugen Ltd COMM M25722105 678 45,107 SH   SOLE   45,107 0 0
Constellation Pharmaceuticals Inc COMM 210373106 2,709 90,144 SH   SOLE   90,144 0 0
Cytokinetics Inc COMM 23282W605 1,644 69,767 SH   SOLE   69,767 0 0
Eli Lilly & Co COMM 532457108 10,644 64,834 SH   SOLE   64,834 0 0
Gilead Sciences Inc COMM 375558103 13,519 175,706 SH   SOLE   175,706 0 0
SPDR Ser Tr S&P Biotech 81369Y959 6,535 65,300 SH Put SOLE   65,300 0 0
Homology Medicines Inc COMM 438083107 2,185 143,831 SH   SOLE   143,831 0 0
Horizon Therapeutics PLC COMM G46188101 6,120 110,120 SH   SOLE   110,120 0 0
Immunovant Inc COMM 45258J102 447 18,338 SH   SOLE   18,338 0 0
Insmed Inc COMM 457669307 5,801 210,646 SH   SOLE   210,646 0 0
Intellia Therapeutics Inc COMM 45826J105 527 25,050 SH   SOLE   25,050 0 0
Intra-Cellular Therapies Inc COMM 46116X101 2,704 105,346 SH   SOLE   105,346 0 0
Intra-Cellular Therapies Inc COMM 46116X951 2,462 95,900 SH Put SOLE   95,900 0 0
Invesco QQQ Trust UNIT SER 1 46090E953 3,244 13,100 SH Put SOLE   13,100 0 0
Jazz Pharmaceuticals PLC COMM G50871105 11,693 105,975 SH   SOLE   105,975 0 0
Kadmon Holdings Inc COMM 48283N106 3,412 666,381 SH   SOLE   666,381 0 0
Kala Pharmaceuticals Inc COMM 483119103 2,319 220,610 SH   SOLE   220,610 0 0
Kura Oncology Inc COMM 50127T109 4,337 266,058 SH   SOLE   266,058 0 0
Liquidia Technologies Inc COMM 53635D202 2,933 348,305 SH   SOLE   348,305 0 0
Menlo Therapeutics Inc COMM 586858102 547 316,027 SH   SOLE   316,027 0 0
Merck & Co Inc COMM 58933Y105 15,233 196,985 SH   SOLE   196,985 0 0
Mersana Therapeutics Inc COMM 59045L106 1,408 60,184 SH   SOLE   60,184 0 0
Mirati Therapeutics Inc COMM 60468T105 401 3,514 SH   SOLE   3,514 0 0
Mirum Pharmaceuticals Inc COMM 604749101 4,590 235,882 SH   SOLE   235,882 0 0
MyoKardia Inc COMM 62857M105 4,718 48,826 SH   SOLE   48,826 0 0
Novocure Ltd COMM G6674U908 1,293 21,800 SH Call SOLE   21,800 0 0
Oric Pharmaceuticals Inc COMM 68622P109 255 7,569 SH   SOLE   7,569 0 0
Otonomy Inc COMM 68906L105 2,672 738,154 SH   SOLE   738,154 0 0
PTC Therapeutics Inc COMM 69366J200 9,710 191,358 SH   SOLE   191,358 0 0
PTC Therapeutics Inc COMM 69366J900 1,324 26,100 SH Call SOLE   26,100 0 0
Pfizer Inc COMM 717081903 2,492 76,200 SH Call SOLE   76,200 0 0
Protagonist Therapeutics Inc COMM 74366E102 2,508 142,020 SH   SOLE   142,020 0 0
Puma Biotechnology Inc COMM 74587V107 5,427 520,370 SH   SOLE   520,370 0 0
Reata Pharmaceuticals Inc COMM 75615P103 886 5,680 SH   SOLE   5,680 0 0
Rigel Pharmaceuticals Inc COMM 766559603 271 147,828 SH   SOLE   147,828 0 0
SPDR Ser Tr S&P Biotech 78464A950 7,310 65,300 SH Put SOLE   65,300 0 0
Supernus Pharmaceuticals Inc COMM 868459108 4,959 208,815 SH   SOLE   208,815 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 601 40,583 SH   SOLE   40,583 0 0
TG Therapeutics Inc COMM 88322Q108 5,910 303,374 SH   SOLE   303,374 0 0
United Therapeutics Corp COMM 91307C102 16,048 132,624 SH   SOLE   132,624 0 0
Zymeworks Inc COMM 98985W102 4,394 121,815 SH   SOLE   121,815 0 0
iShares Tr Russell 2000 ETF 464287955 4,367 30,500 SH Put SOLE   30,500 0 0
Abbvie Inc COMM 00287Y109 4,067 41,422 SH   OTR 1 41,422 0 0
Acceleron Pharma Inc COMM 00434H108 3,408 35,774 SH   OTR 1 35,774 0 0
Akebia Therapeutics Inc COMM 00972D105 1,525 112,262 SH   OTR 1 112,262 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 3,658 24,700 SH Call OTR 1 24,700 0 0
Amgen Inc COMM 031162950 6,510 27,600 SH Put OTR 1 27,600 0 0
Applied Genetic Technologies Corp COMM 03820J100 973 175,613 SH   OTR 1 175,613 0 0
Arena Pharmaceuticals Inc COMM 040047607 144 2,292 SH   OTR 1 2,292 0 0
Axsome Therapeutics Inc COMM 05464T104 1,178 14,319 SH   OTR 1 14,319 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 1,063 223,133 SH   OTR 1 223,133 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 1,275 10,340 SH   OTR 1 10,340 0 0
Blueprint Medicines Corp COMM 09627Y109 1,217 15,607 SH   OTR 1 15,607 0 0
Calithera Biosciences Inc COMM 13089P101 787 149,096 SH   OTR 1 149,096 0 0
ChemoCentryx Inc COMM 16383L106 918 15,954 SH   OTR 1 15,954 0 0
Compugen Ltd COMM M25722105 256 17,030 SH   OTR 1 17,030 0 0
Constellation Pharmaceuticals Inc COMM 210373106 1,024 34,077 SH   OTR 1 34,077 0 0
Cytokinetics Inc COMM 23282W605 621 26,340 SH   OTR 1 26,340 0 0
Eli Lilly & Co COMM 532457108 4,021 24,493 SH   OTR 1 24,493 0 0
Gilead Sciences Inc COMM 375558103 5,104 66,335 SH   OTR 1 66,335 0 0
Select Sector SPDR Tr SBI Healthcare 81369Y959 2,472 24,700 SH Put OTR 1 24,700 0 0
Homology Medicines Inc COMM 438083107 826 54,376 SH   OTR 1 54,376 0 0
Horizon Therapeutics PLC COMM G46188101 2,314 41,630 SH   OTR 1 41,630 0 0
Immunovant Inc COMM 45258J102 168 6,900 SH   OTR 1 6,900 0 0
Insmed Inc COMM 457669307 2,193 79,643 SH   OTR 1 79,643 0 0
Intellia Therapeutics Inc COMM 45826J105 199 9,459 SH   OTR 1 9,459 0 0
Intra-Cellular Therapies Inc COMM 46116X951 929 36,200 SH Put OTR 1 36,200 0 0
Intra-Cellular Therapies Inc COMM 46116X101 1,021 39,793 SH   OTR 1 39,793 0 0
Invesco QQQ Trust UNIT SER 1 46090E953 1,213 4,900 SH Put OTR 1 4,900 0 0
Jazz Pharmaceuticals PLC COMM G50871105 4,417 40,035 SH   OTR 1 40,035 0 0
Kadmon Holdings Inc COMM 48283N106 1,290 251,920 SH   OTR 1 251,920 0 0
Kala Pharmaceuticals Inc COMM 483119103 876 83,359 SH   OTR 1 83,359 0 0
Kura Oncology Inc COMM 50127T109 1,637 100,445 SH   OTR 1 100,445 0 0
Liquidia Technologies Inc COMM 53635D202 1,109 131,694 SH   OTR 1 131,694 0 0
Menlo Therapeutics Inc COMM 586858102 207 119,406 SH   OTR 1 119,406 0 0
Merck & Co Inc COMM 58933Y105 5,739 74,217 SH   OTR 1 74,217 0 0
Mersana Therapeutics Inc COMM 59045L106 531 22,681 SH   OTR 1 22,681 0 0
Mirati Therapeutics Inc COMM 60468T105 152 1,328 SH   OTR 1 1,328 0 0
Mirum Pharmaceuticals Inc COMM 604749101 1,735 89,150 SH   OTR 1 89,150 0 0
MyoKardia Inc COMM 62857M105 1,776 18,385 SH   OTR 1 18,385 0 0
Novocure Ltd COMM G6674U908 486 8,200 SH Call OTR 1 8,200 0 0
Oric Pharmaceuticals Inc COMM 68622P109 96 2,858 SH   OTR 1 2,858 0 0
Otonomy Inc COMM 68906L105 1,028 283,853 SH   OTR 1 283,853 0 0
PTC Therapeutics Inc COMM 69366J200 3,658 72,085 SH   OTR 1 72,085 0 0
PTC Therapeutics Inc COMM 69366J900 502 9,900 SH Call OTR 1 9,900 0 0
Pfizer Inc COMM 717081903 942 28,800 SH Call OTR 1 28,800 0 0
Protagonist Therapeutics Inc COMM 74366E102 947 53,626 SH   OTR 1 53,626 0 0
Puma Biotechnology Inc COMM 74587V107 2,055 196,982 SH   OTR 1 196,982 0 0
Reata Pharmaceuticals Inc COMM 75615P103 335 2,146 SH   OTR 1 2,146 0 0
Rigel Pharmaceuticals Inc COMM 766559603 102 55,898 SH   OTR 1 55,898 0 0
SPDR Ser Tr S&P Biotech 78464A950 2,765 24,700 SH Put OTR 1 24,700 0 0
Supernus Pharmaceuticals Inc COMM 868459108 1,868 78,672 SH   OTR 1 78,672 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 227 15,286 SH   OTR 1 15,286 0 0
TG Therapeutics Inc COMM 88322Q108 2,233 114,646 SH   OTR 1 114,646 0 0
United Therapeutics Corp COMM 91307C102 6,066 50,133 SH   OTR 1 50,133 0 0
Zymeworks Inc COMM 98985W102 1,654 45,848 SH   OTR 1 45,848 0 0
iShares Tr Russell 2000 ETF 464287955 1,647 11,500 SH Put OTR 1 11,500 0 0
Abbvie Inc COMM 00287Y109 9,899 100,820 SH   OTR 2 100,820 0 0
Acceleron Pharma Inc COMM 00434H108 8,286 86,975 SH   OTR 2 86,975 0 0
Akebia Therapeutics Inc COMM 00972D105 3,704 272,718 SH   OTR 2 272,718 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 8,887 60,000 SH Call OTR 2 60,000 0 0
Amgen Inc COMM 031162950 15,897 67,400 SH Put OTR 2 67,400 0 0
Applied Genetic Technologies Corp COMM 03820J100 2,790 503,538 SH   OTR 2 503,538 0 0
Arena Pharmaceuticals Inc COMM 040047607 351 5,572 SH   OTR 2 5,572 0 0
Axsome Therapeutics Inc COMM 05464T104 2,862 34,788 SH   OTR 2 34,788 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 2,586 542,609 SH   OTR 2 542,609 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 3,104 25,167 SH   OTR 2 25,167 0 0
Blueprint Medicines Corp COMM 09627Y109 2,953 37,857 SH   OTR 2 37,857 0 0
Calithera Biosciences Inc COMM 13089P101 2,614 495,126 SH   OTR 2 495,126 0 0
ChemoCentryx Inc COMM 16383L106 2,231 38,770 SH   OTR 2 38,770 0 0
Compugen Ltd COMM M25722105 623 41,450 SH   OTR 2 41,450 0 0
Constellation Pharmaceuticals Inc COMM 210373106 2,490 82,866 SH   OTR 2 82,866 0 0
Cytokinetics Inc COMM 23282W605 1,511 64,110 SH   OTR 2 64,110 0 0
Eli Lilly & Co COMM 532457108 9,781 59,573 SH   OTR 2 59,573 0 0
Gilead Sciences Inc COMM 375558103 12,422 161,453 SH   OTR 2 161,453 0 0
Select Sector SPDR Tr SBI Healthcare 81369Y959 6,004 60,000 SH Put OTR 2 60,000 0 0
Homology Medicines Inc COMM 438083107 2,223 146,372 SH   OTR 2 146,372 0 0
Horizon Therapeutics PLC COMM G46188101 5,625 101,208 SH   OTR 2 101,208 0 0
Immunovant Inc COMM 45258J102 372 15,275 SH   OTR 2 15,275 0 0
Insmed Inc COMM 457669307 5,334 193,678 SH   OTR 2 193,678 0 0
Intellia Therapeutics Inc COMM 45826J105 483 22,991 SH   OTR 2 22,991 0 0
Intra-Cellular Therapies Inc COMM 46116X951 2,256 87,900 SH Put OTR 2 87,900 0 0
Intra-Cellular Therapies Inc COMM 46116X101 2,484 96,769 SH   OTR 2 96,769 0 0
Invesco QQQ Trust UNIT SER 1 46090E953 2,971 12,000 SH Put OTR 2 12,000 0 0
Jazz Pharmaceuticals PLC COMM G50871105 10,741 97,343 SH   OTR 2 97,343 0 0
Kadmon Holdings Inc COMM 48283N106 3,136 612,563 SH   OTR 2 612,563 0 0
Kala Pharmaceuticals Inc COMM 483119103 2,130 202,678 SH   OTR 2 202,678 0 0
Kura Oncology Inc COMM 50127T109 3,985 244,476 SH   OTR 2 244,476 0 0
Liquidia Technologies Inc COMM 53635D202 2,694 320,001 SH   OTR 2 320,001 0 0
Menlo Therapeutics Inc COMM 586858102 502 290,138 SH   OTR 2 290,138 0 0
Merck & Co Inc COMM 58933Y105 13,918 179,976 SH   OTR 2 179,976 0 0
Mersana Therapeutics Inc COMM 59045L106 1,289 55,101 SH   OTR 2 55,101 0 0
Mirati Therapeutics Inc COMM 60468T105 369 3,230 SH   OTR 2 3,230 0 0
Mirum Pharmaceuticals Inc COMM 604749101 4,216 216,669 SH   OTR 2 216,669 0 0
MyoKardia Inc COMM 62857M105 4,309 44,599 SH   OTR 2 44,599 0 0
Novocure Ltd COMM G6674U908 1,186 20,000 SH Call OTR 2 20,000 0 0
Oric Pharmaceuticals Inc COMM 68622P109 234 6,942 SH   OTR 2 6,942 0 0
Otonomy Inc COMM 68906L105 2,278 629,404 SH   OTR 2 629,404 0 0
PTC Therapeutics Inc COMM 69366J200 8,871 174,827 SH   OTR 2 174,827 0 0
PTC Therapeutics Inc COMM 69366J900 1,218 24,000 SH Call OTR 2 24,000 0 0
Pfizer Inc COMM 717081903 2,289 70,000 SH Call OTR 2 70,000 0 0
Protagonist Therapeutics Inc COMM 74366E102 2,303 130,418 SH   OTR 2 130,418 0 0
Puma Biotechnology Inc COMM 74587V107 5,009 480,278 SH   OTR 2 480,278 0 0
Reata Pharmaceuticals Inc COMM 75615P103 813 5,209 SH   OTR 2 5,209 0 0
Rigel Pharmaceuticals Inc COMM 766559603 249 135,969 SH   OTR 2 135,969 0 0
SPDR Ser Tr S&P Biotech 78464A950 6,717 60,000 SH Put OTR 2 60,000 0 0
Supernus Pharmaceuticals Inc COMM 868459108 4,532 190,842 SH   OTR 2 190,842 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 535 36,095 SH   OTR 2 36,095 0 0
TG Therapeutics Inc COMM 88322Q108 5,423 278,370 SH   OTR 2 278,370 0 0
United Therapeutics Corp COMM 91307C102 14,738 121,805 SH   OTR 2 121,805 0 0
Zymeworks Inc COMM 98985W102 4,764 132,071 SH   OTR 2 132,071 0 0
iShares Tr Russell 2000 ETF 464287955 4,009 28,000 SH Put OTR 2 28,000 0 0