The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALECTOR INC COM 014442107 8,299 339,569 SH   DFND   339,569 0 0
APTINYX INC COM 03836N103 13,720 3,290,079 SH   DFND   3,290,079 0 0
ARAVIVE INC COM 03890D108 11,016 946,423 SH   DFND   946,423 0 0
ARVINAS INC COM 04335A105 76,573 2,283,048 SH   DFND   2,283,048 0 0
AVROBIO INC COM 05455M100 5,506 315,550 SH   DFND   315,550 0 0
CHIASMA INC COM 16706W102 3,958 735,700 SH   DFND   735,700 0 0
CHIMERIX INC COM 16934W106 4,185 1,350,000 SH   DFND   1,350,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 2,470 141,000 SH   DFND   141,000 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 72,236 1,209,571 SH   DFND   1,209,571 0 0
HARPOON THERAPEUTICS INC COM 41358P106 48,495 2,921,405 SH   DFND   2,921,405 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 1,733 1,456,303 SH   DFND   1,456,303 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,623 449,500 SH   DFND   449,500 0 0
NEURONETICS INC COM 64131A105 1,043 540,317 SH   DFND   540,317 0 0
OBSEVA SA COM H5861P103 5,304 900,501 SH   DFND   900,501 0 0
PASSAGE BIO COM 702712100 68,268 2,497,922 SH   DFND   2,497,922 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 236 117,242 SH   DFND   117,242 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 14,934 249,774 SH   DFND   249,774 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,956 409,611 SH   DFND   409,611 0 0
UNUM THERAPEUTICS INC COM 903214104 826 1,795,545 SH   DFND   1,795,545 0 0
X4 PHARMACEUTICALS INC COM 98420X103 3,122 335,000 SH   DFND   335,000 0 0