The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 10X Genomics Inc Class A | CL A COM | 88025U109 | 384 | 4,297 | SH | DFND | 3 | 4,297 | 0 | 0 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 10,052 | 186,347 | SH | DFND | 1 | 186,347 | 0 | 0 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 35,987 | 667,163 | SH | DFND | 2 | 614,825 | 0 | 52,338 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 7,356 | 136,366 | SH | DFND | 3 | 65,402 | 0 | 70,964 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 25,038 | 464,183 | SH | SOLE | 0 | 429,764 | 0 | 34,419 | |
| AJ Gallagher & Co | COM | 363576109 | 114,146 | 1,170,849 | SH | DFND | 1 | 1,170,849 | 0 | 0 | |
| AJ Gallagher & Co | COM | 363576109 | 374,158 | 3,837,914 | SH | DFND | 2 | 3,559,208 | 0 | 278,706 | |
| AJ Gallagher & Co | COM | 363576109 | 73,606 | 755,007 | SH | DFND | 3 | 353,334 | 0 | 401,673 | |
| AJ Gallagher & Co | COM | 363576109 | 248,657 | 2,550,592 | SH | SOLE | 0 | 2,370,335 | 0 | 180,257 | |
| Abiomed | COM | 003654100 | 200,344 | 829,376 | SH | DFND | 1 | 829,376 | 0 | 0 | |
| Abiomed | COM | 003654100 | 298,867 | 1,237,236 | SH | DFND | 2 | 1,157,287 | 0 | 79,949 | |
| Abiomed | COM | 003654100 | 48,674 | 201,500 | SH | DFND | 3 | 98,393 | 0 | 103,107 | |
| Abiomed | COM | 003654100 | 139,378 | 576,992 | SH | SOLE | 0 | 546,208 | 0 | 30,784 | |
| Activision Blizzard Inc | COM | 00507V109 | 55,103 | 725,998 | SH | DFND | 1 | 725,998 | 0 | 0 | |
| Activision Blizzard Inc | COM | 00507V109 | 67,578 | 890,353 | SH | DFND | 2 | 767,247 | 0 | 123,106 | |
| Activision Blizzard Inc | COM | 00507V109 | 824 | 10,860 | SH | DFND | 3 | 10,860 | 0 | 0 | |
| Activision Blizzard Inc | COM | 00507V109 | 13,972 | 184,088 | SH | SOLE | 0 | 184,088 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 24,221 | 2,419,653 | SH | DFND | 1 | 2,419,653 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 15,504 | 1,548,822 | SH | DFND | 2 | 603,824 | 0 | 944,998 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 4,889 | 488,402 | SH | DFND | 3 | 488,402 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 8,336 | 832,792 | SH | SOLE | 0 | 832,792 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 4,576 | 1,980,937 | SH | DFND | 1 | 1,980,937 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 2,933 | 1,269,842 | SH | DFND | 2 | 539,524 | 0 | 730,318 | |
| Aduro Biotechnology | COM | 00739L101 | 1,032 | 446,648 | SH | DFND | 3 | 446,648 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 1,352 | 585,293 | SH | SOLE | 0 | 585,293 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 25,419 | 319,217 | SH | DFND | 1 | 319,217 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 20,766 | 260,784 | SH | DFND | 2 | 101,040 | 0 | 159,744 | |
| Aerovironment | COM | 008073108 | 6,565 | 82,441 | SH | DFND | 3 | 82,441 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 17,564 | 220,567 | SH | SOLE | 0 | 220,567 | 0 | 0 | |
| Agora Inc ADR | ADS | 00851L103 | 10,251 | 232,088 | SH | DFND | 1 | 232,088 | 0 | 0 | |
| Agora Inc ADR | ADS | 00851L103 | 7,417 | 167,912 | SH | SOLE | 0 | 167,912 | 0 | 0 | |
| Albemarle Corp | COM | 012653101 | 53,028 | 686,808 | SH | DFND | 1 | 686,808 | 0 | 0 | |
| Albemarle Corp | COM | 012653101 | 147,912 | 1,915,714 | SH | DFND | 2 | 1,764,162 | 0 | 151,552 | |
| Albemarle Corp | COM | 012653101 | 29,998 | 388,527 | SH | DFND | 3 | 179,733 | 0 | 208,794 | |
| Albemarle Corp | COM | 012653101 | 110,423 | 1,430,166 | SH | SOLE | 0 | 1,335,082 | 0 | 95,084 | |
| Alector Inc | COM | 014442107 | 90 | 3,666 | SH | DFND | 3 | 3,666 | 0 | 0 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 528,209 | 2,448,811 | SH | DFND | 1 | 2,448,811 | 0 | 0 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 6,180,868 | 28,654,930 | SH | DFND | 2 | 21,024,094 | 0 | 7,630,836 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 272,234 | 1,262,095 | SH | DFND | 3 | 707,647 | 0 | 554,448 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 1,809,976 | 8,391,175 | SH | SOLE | 0 | 6,972,946 | 0 | 1,418,229 | |
| Align Technology Inc | COM | 016255101 | 10,309 | 37,565 | SH | DFND | 2 | 37,565 | 0 | 0 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 299,328 | 2,020,983 | SH | DFND | 1 | 2,020,983 | 0 | 0 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 534,888 | 3,611,423 | SH | DFND | 2 | 3,044,131 | 0 | 567,292 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 108,190 | 730,470 | SH | DFND | 3 | 438,284 | 0 | 292,186 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 338,550 | 2,285,802 | SH | SOLE | 0 | 2,180,147 | 0 | 105,655 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 43,407 | 30,610 | SH | DFND | 1 | 30,610 | 0 | 0 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 65,816 | 46,413 | SH | DFND | 2 | 37,128 | 0 | 9,285 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 22,049 | 15,549 | SH | DFND | 3 | 7,276 | 0 | 8,273 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 113,087 | 79,748 | SH | SOLE | 0 | 79,748 | 0 | 0 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 562,823 | 398,146 | SH | DFND | 1 | 398,146 | 0 | 0 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 1,840,773 | 1,302,179 | SH | DFND | 2 | 850,749 | 0 | 451,430 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 223,083 | 157,811 | SH | DFND | 3 | 84,857 | 0 | 72,954 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 932,756 | 659,840 | SH | SOLE | 0 | 531,898 | 0 | 127,942 | |
| Amazon.Com | COM | 023135106 | 1,313,085 | 475,959 | SH | DFND | 1 | 475,959 | 0 | 0 | |
| Amazon.Com | COM | 023135106 | 6,280,818 | 2,276,632 | SH | DFND | 2 | 1,567,300 | 0 | 709,332 | |
| Amazon.Com | COM | 023135106 | 471,686 | 170,974 | SH | DFND | 3 | 97,810 | 0 | 73,164 | |
| Amazon.Com | COM | 023135106 | 3,298,776 | 1,195,720 | SH | SOLE | 0 | 1,019,119 | 0 | 176,601 | |
| Ambarella | SHS | G037AX101 | 8,368 | 182,700 | SH | DFND | 1 | 182,700 | 0 | 0 | |
| Ambarella | SHS | G037AX101 | 6,553 | 143,073 | SH | DFND | 2 | 55,074 | 0 | 87,999 | |
| Ambarella | SHS | G037AX101 | 2,064 | 45,067 | SH | DFND | 3 | 45,067 | 0 | 0 | |
| Ambarella | SHS | G037AX101 | 4,470 | 97,605 | SH | SOLE | 0 | 97,605 | 0 | 0 | |
| Ameren | COM | 023608102 | 30,315 | 430,850 | SH | DFND | 1 | 430,850 | 0 | 0 | |
| Ameren | COM | 023608102 | 72 | 1,020 | SH | DFND | 2 | 1,020 | 0 | 0 | |
| Ameren | COM | 023608102 | 2,069 | 29,407 | SH | DFND | 3 | 29,407 | 0 | 0 | |
| American Electric Power | COM | 025537101 | 30,510 | 383,100 | SH | DFND | 1 | 383,100 | 0 | 0 | |
| American Electric Power | COM | 025537101 | 72 | 900 | SH | DFND | 2 | 900 | 0 | 0 | |
| American Electric Power | COM | 025537101 | 2,028 | 25,469 | SH | DFND | 3 | 25,469 | 0 | 0 | |
| American Express | COM | 025816109 | 13,498 | 141,786 | SH | DFND | 2 | 141,786 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 18,559 | 151,330 | SH | DFND | 1 | 151,330 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 927 | 7,560 | SH | DFND | 2 | 0 | 0 | 7,560 | |
| Analog Devices | COM | 032654105 | 24 | 195 | SH | DFND | 3 | 195 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 20,092 | 163,830 | SH | SOLE | 0 | 163,830 | 0 | 0 | |
| Anaplan Inc Common | COM | 03272L108 | 84,804 | 1,871,644 | SH | SOLE | 0 | 1,871,644 | 0 | 0 | |
| Annaly Capital Man. | COM | 035710409 | 49 | 7,446 | SH | DFND | 1 | 7,446 | 0 | 0 | |
| Anthem Inc | COM | 036752103 | 146,784 | 558,158 | SH | DFND | 1 | 558,158 | 0 | 0 | |
| Anthem Inc | COM | 036752103 | 492,611 | 1,873,188 | SH | DFND | 2 | 1,731,066 | 0 | 142,122 | |
| Anthem Inc | COM | 036752103 | 102,376 | 389,293 | SH | DFND | 3 | 181,181 | 0 | 208,112 | |
| Anthem Inc | COM | 036752103 | 335,474 | 1,275,665 | SH | SOLE | 0 | 1,180,998 | 0 | 94,667 | |
| Appian Corp | CL A | 03782L101 | 69,618 | 1,358,392 | SH | DFND | 1 | 1,358,392 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 73,542 | 1,434,958 | SH | DFND | 2 | 1,083,905 | 0 | 351,053 | |
| Appian Corp | CL A | 03782L101 | 8,760 | 170,929 | SH | DFND | 3 | 170,929 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 40,282 | 785,982 | SH | SOLE | 0 | 785,982 | 0 | 0 | |
| Apple | COM | 037833100 | 16,993 | 46,583 | SH | DFND | 1 | 46,583 | 0 | 0 | |
| Apple | COM | 037833100 | 958 | 2,625 | SH | DFND | 2 | 0 | 0 | 2,625 | |
| Apple | COM | 037833100 | 22 | 61 | SH | DFND | 3 | 61 | 0 | 0 | |
| Apple | COM | 037833100 | 18,449 | 50,572 | SH | SOLE | 0 | 50,572 | 0 | 0 | |
| Ares Capital Corp | COM | 04010L103 | 24,926 | 1,725,000 | SH | DFND | 1 | 1,725,000 | 0 | 0 | |
| Ares Capital Corp | COM | 04010L103 | 51 | 3,500 | SH | DFND | 2 | 3,500 | 0 | 0 | |
| Ares Capital Corp | COM | 04010L103 | 1,393 | 96,370 | SH | DFND | 3 | 96,370 | 0 | 0 | |
| Atlassian Corp Plc | CL A | G06242104 | 124,478 | 690,511 | SH | DFND | 1 | 690,511 | 0 | 0 | |
| Atlassian Corp Plc | CL A | G06242104 | 822,930 | 4,564,985 | SH | DFND | 2 | 1,701,176 | 0 | 2,863,809 | |
| Atlassian Corp Plc | CL A | G06242104 | 66,694 | 369,965 | SH | DFND | 3 | 241,039 | 0 | 128,926 | |
| Atlassian Corp Plc | CL A | G06242104 | 266,176 | 1,476,542 | SH | SOLE | 0 | 761,587 | 0 | 714,955 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 30,282 | 401,089 | SH | DFND | 1 | 401,089 | 0 | 0 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 108,241 | 1,433,652 | SH | DFND | 2 | 1,322,326 | 0 | 111,326 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 22,514 | 298,202 | SH | DFND | 3 | 138,723 | 0 | 159,479 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 77,845 | 1,031,055 | SH | SOLE | 0 | 957,858 | 0 | 73,197 | |
| Avangrid | COM | 05351W103 | 30,172 | 718,730 | SH | DFND | 1 | 718,730 | 0 | 0 | |
| Avangrid | COM | 05351W103 | 74 | 1,760 | SH | DFND | 2 | 1,760 | 0 | 0 | |
| Avangrid | COM | 05351W103 | 2,090 | 49,780 | SH | DFND | 3 | 49,780 | 0 | 0 | |
| Axogen Inc | COM | 05463X106 | 3,318 | 359,100 | SH | DFND | 1 | 359,100 | 0 | 0 | |
| Axogen Inc | COM | 05463X106 | 3,880 | 419,912 | SH | DFND | 2 | 165,337 | 0 | 254,575 | |
| Axogen Inc | COM | 05463X106 | 1,224 | 132,520 | SH | DFND | 3 | 132,520 | 0 | 0 | |
| Axogen Inc | COM | 05463X106 | 1,567 | 169,600 | SH | SOLE | 0 | 169,600 | 0 | 0 | |
| Axon Enterprise Inc | COM | 05464C101 | 64,588 | 658,184 | SH | DFND | 1 | 658,184 | 0 | 0 | |
| Axon Enterprise Inc | COM | 05464C101 | 185,707 | 1,892,464 | SH | DFND | 2 | 1,625,797 | 0 | 266,667 | |
| Axon Enterprise Inc | COM | 05464C101 | 42,023 | 428,238 | SH | DFND | 3 | 238,950 | 0 | 189,288 | |
| Axon Enterprise Inc | COM | 05464C101 | 123,618 | 1,259,736 | SH | SOLE | 0 | 1,175,366 | 0 | 84,370 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 10,805 | 90,123 | SH | DFND | 1 | 90,123 | 0 | 0 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 495,944 | 4,136,661 | SH | DFND | 2 | 3,913,775 | 0 | 222,886 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 22,086 | 184,219 | SH | DFND | 3 | 14,895 | 0 | 169,324 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 1,063 | 8,867 | SH | DFND | 4 | 8,867 | 0 | 0 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 796 | 6,639 | SH | SOLE | 0 | 6,639 | 0 | 0 | |
| BanColombia Pref ADR | SPON ADR PREF | 05968L102 | 6,766 | 257,155 | SH | DFND | 2 | 0 | 0 | 257,155 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 15,544 | 4,079,727 | SH | DFND | 1 | 4,079,727 | 0 | 0 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 103,088 | 27,057,177 | SH | DFND | 2 | 13,096,657 | 0 | 13,960,520 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 2,117 | 555,599 | SH | DFND | 3 | 555,599 | 0 | 0 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 20,444 | 531,708 | SH | DFND | 1 | 531,708 | 0 | 0 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 18,213 | 473,682 | SH | DFND | 2 | 183,487 | 0 | 290,195 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 5,729 | 148,990 | SH | DFND | 3 | 148,990 | 0 | 0 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 11,308 | 294,100 | SH | SOLE | 0 | 294,100 | 0 | 0 | |
| Barrick Gold Corp | COM | 067901108 | 212 | 7,900 | SH | DFND | 2 | 7,900 | 0 | 0 | |
| Beigene Ltd | SPONSORED ADR | 07725L102 | 10,658 | 56,570 | SH | DFND | 1 | 56,570 | 0 | 0 | |
| Beigene Ltd | SPONSORED ADR | 07725L102 | 50,795 | 269,613 | SH | DFND | 2 | 138,508 | 0 | 131,105 | |
| Benefitfocus Inc | COM | 08180D106 | 3,297 | 306,448 | SH | DFND | 1 | 306,448 | 0 | 0 | |
| Benefitfocus Inc | COM | 08180D106 | 3,402 | 316,210 | SH | DFND | 2 | 108,529 | 0 | 207,681 | |
| Benefitfocus Inc | COM | 08180D106 | 1,240 | 115,203 | SH | DFND | 3 | 115,203 | 0 | 0 | |
| Benefitfocus Inc | COM | 08180D106 | 2,436 | 226,368 | SH | SOLE | 0 | 226,368 | 0 | 0 | |
| Beyond Meat Inc | COM | 08862E109 | 7,613 | 56,823 | SH | DFND | 1 | 56,823 | 0 | 0 | |
| Beyond Meat Inc | COM | 08862E109 | 2,649 | 19,771 | SH | DFND | 2 | 14,221 | 0 | 5,550 | |
| Beyond Meat Inc | COM | 08862E109 | 4,111 | 30,684 | SH | DFND | 3 | 11,843 | 0 | 18,841 | |
| Bilibili Inc ADR | SPONSORED ADR | 090040106 | 2,321 | 50,113 | SH | DFND | 1 | 50,113 | 0 | 0 | |
| BitAuto Holdings Ltd - ADR | SPONSORED ADS | 091727107 | 265 | 16,750 | SH | SOLE | 0 | 16,750 | 0 | 0 | |
| BlackRock Floating Rate Income | COM | 091941104 | 8,611 | 784,230 | SH | DFND | 1 | 784,230 | 0 | 0 | |
| Blackline | COM | 09239B109 | 28,026 | 338,032 | SH | DFND | 1 | 338,032 | 0 | 0 | |
| Blackline | COM | 09239B109 | 19,906 | 240,095 | SH | DFND | 2 | 93,066 | 0 | 147,029 | |
| Blackline | COM | 09239B109 | 6,233 | 75,179 | SH | DFND | 3 | 75,179 | 0 | 0 | |
| Blackline | COM | 09239B109 | 11,539 | 139,175 | SH | SOLE | 0 | 139,175 | 0 | 0 | |
| Blue Apron Holdings Inc | CL A | 09523Q101 | 1,647 | 148,506 | SH | DFND | 1 | 148,506 | 0 | 0 | |
| Bluebird Bio Inc | COM | 09609G100 | 69 | 1,127 | SH | DFND | 3 | 1,127 | 0 | 0 | |
| Bluebird Bio Inc | COM | 09609G100 | 42,423 | 695,000 | SH | SOLE | 0 | 695,000 | 0 | 0 | |
| Booking Holdings Inc | COM | 09857L108 | 34,910 | 21,924 | SH | DFND | 1 | 21,924 | 0 | 0 | |
| Booking Holdings Inc | COM | 09857L108 | 117,836 | 74,002 | SH | DFND | 2 | 65,740 | 0 | 8,262 | |
| Booking Holdings Inc | COM | 09857L108 | 24,637 | 15,472 | SH | DFND | 3 | 7,194 | 0 | 8,278 | |
| Booking Holdings Inc | COM | 09857L108 | 80,577 | 50,603 | SH | SOLE | 0 | 46,896 | 0 | 3,707 | |
| BridgeBio Pharma Inc | COM | 10806X102 | 189 | 5,809 | SH | DFND | 3 | 5,809 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 3,806 | 98,030 | SH | DFND | 1 | 98,030 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 177 | 4,555 | SH | DFND | 2 | 0 | 0 | 4,555 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 6 | 148 | SH | DFND | 3 | 148 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 4,504 | 116,021 | SH | SOLE | 0 | 116,021 | 0 | 0 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 70,915 | 561,969 | SH | DFND | 1 | 561,969 | 0 | 0 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 257,716 | 2,042,288 | SH | DFND | 2 | 1,898,275 | 0 | 144,013 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 49,561 | 392,750 | SH | DFND | 3 | 181,099 | 0 | 211,651 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 162,180 | 1,285,203 | SH | SOLE | 0 | 1,189,975 | 0 | 95,228 | |
| Burning Rock Biotech Ltd ADR | SPON ADS | 12233L107 | 11,420 | 422,800 | SH | DFND | 1 | 422,800 | 0 | 0 | |
| Burning Rock Biotech Ltd ADR | SPON ADS | 12233L107 | 5,002 | 185,200 | SH | DFND | 3 | 400 | 0 | 184,800 | |
| Burning Rock Biotech Ltd ADR | SPON ADS | 12233L107 | 2,987 | 110,600 | SH | SOLE | 0 | 110,600 | 0 | 0 | |
| CEVA Inc | COM | 157210105 | 5,874 | 156,980 | SH | DFND | 1 | 156,980 | 0 | 0 | |
| CEVA Inc | COM | 157210105 | 6,386 | 170,651 | SH | DFND | 2 | 65,130 | 0 | 105,521 | |
| CEVA Inc | COM | 157210105 | 2,037 | 54,437 | SH | DFND | 3 | 54,437 | 0 | 0 | |
| CEVA Inc | COM | 157210105 | 3,087 | 82,500 | SH | SOLE | 0 | 82,500 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 20,497 | 259,255 | SH | DFND | 1 | 259,255 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 991 | 12,531 | SH | DFND | 2 | 0 | 0 | 12,531 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 26 | 326 | SH | DFND | 3 | 326 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 21,917 | 277,224 | SH | SOLE | 0 | 277,224 | 0 | 0 | |
| Cbre Group Inc | CL A | 12504L109 | 32,202 | 712,114 | SH | DFND | 1 | 712,114 | 0 | 0 | |
| Cbre Group Inc | CL A | 12504L109 | 134,676 | 2,978,239 | SH | DFND | 2 | 2,691,958 | 0 | 286,281 | |
| Cbre Group Inc | CL A | 12504L109 | 23,763 | 525,506 | SH | DFND | 3 | 248,163 | 0 | 277,343 | |
| Cbre Group Inc | CL A | 12504L109 | 77,061 | 1,704,128 | SH | SOLE | 0 | 1,578,585 | 0 | 125,543 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 13,289 | 4,614,397 | SH | DFND | 1 | 4,614,397 | 0 | 0 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 74,927 | 26,016,392 | SH | DFND | 2 | 10,569,177 | 0 | 15,447,215 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 24,896 | 8,644,450 | SH | DFND | 3 | 469,018 | 0 | 8,175,432 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 1,255 | 435,758 | SH | DFND | 4 | 435,758 | 0 | 0 | |
| Chegg | COM | 163092109 | 308,313 | 4,583,900 | SH | DFND | 1 | 4,583,900 | 0 | 0 | |
| Chegg | COM | 163092109 | 405,249 | 6,025,110 | SH | DFND | 2 | 5,187,996 | 0 | 837,114 | |
| Chegg | COM | 163092109 | 65,338 | 971,420 | SH | DFND | 3 | 646,281 | 0 | 325,139 | |
| Chegg | COM | 163092109 | 207,966 | 3,091,966 | SH | SOLE | 0 | 2,972,752 | 0 | 119,214 | |
| Chewy Inc | CL A | 16679L109 | 104,122 | 2,329,871 | SH | DFND | 1 | 2,329,871 | 0 | 0 | |
| Chewy Inc | CL A | 16679L109 | 104,295 | 2,333,751 | SH | DFND | 2 | 2,223,922 | 0 | 109,829 | |
| Chewy Inc | CL A | 16679L109 | 1,523 | 34,071 | SH | DFND | 3 | 34,071 | 0 | 0 | |
| Chewy Inc | CL A | 16679L109 | 29,038 | 649,760 | SH | SOLE | 0 | 649,760 | 0 | 0 | |
| Cisco Systems | COM | 17275R102 | 13,302 | 285,200 | SH | DFND | 1 | 285,200 | 0 | 0 | |
| Cisco Systems | COM | 17275R102 | 532 | 11,400 | SH | DFND | 2 | 0 | 0 | 11,400 | |
| Cisco Systems | COM | 17275R102 | 19 | 400 | SH | DFND | 3 | 400 | 0 | 0 | |
| Cisco Systems | COM | 17275R102 | 13,777 | 295,400 | SH | SOLE | 0 | 295,400 | 0 | 0 | |
| Cloudflare Inc | CL A COM | 18915M107 | 89,322 | 2,484,613 | SH | DFND | 1 | 2,484,613 | 0 | 0 | |
| Cloudflare Inc | CL A COM | 18915M107 | 299,893 | 8,341,951 | SH | DFND | 2 | 4,012,213 | 0 | 4,329,738 | |
| Cloudflare Inc | CL A COM | 18915M107 | 22,077 | 614,101 | SH | DFND | 3 | 405,237 | 0 | 208,864 | |
| Cloudflare Inc | CL A COM | 18915M107 | 100,585 | 2,797,926 | SH | SOLE | 0 | 1,640,462 | 0 | 1,157,464 | |
| CoStar Group | COM | 22160N109 | 130,250 | 183,278 | SH | DFND | 1 | 183,278 | 0 | 0 | |
| CoStar Group | COM | 22160N109 | 144,829 | 203,792 | SH | DFND | 2 | 195,089 | 0 | 8,703 | |
| CoStar Group | COM | 22160N109 | 1,899 | 2,672 | SH | DFND | 3 | 2,672 | 0 | 0 | |
| CoStar Group | COM | 22160N109 | 36,964 | 52,013 | SH | SOLE | 0 | 52,013 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 25,617 | 573,343 | SH | DFND | 1 | 573,343 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 1,196 | 26,768 | SH | DFND | 2 | 0 | 0 | 26,768 | |
| Coca Cola | COM | 191216100 | 33 | 739 | SH | DFND | 3 | 739 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 27,507 | 615,648 | SH | SOLE | 0 | 615,648 | 0 | 0 | |
| Codexis | COM | 192005106 | 19,802 | 1,737,008 | SH | DFND | 1 | 1,737,008 | 0 | 0 | |
| Codexis | COM | 192005106 | 21,376 | 1,875,064 | SH | DFND | 2 | 720,447 | 0 | 1,154,617 | |
| Codexis | COM | 192005106 | 6,773 | 594,164 | SH | DFND | 3 | 594,164 | 0 | 0 | |
| Codexis | COM | 192005106 | 13,246 | 1,161,941 | SH | SOLE | 0 | 1,161,941 | 0 | 0 | |
| Consolidated Edison | COM | 209115104 | 27,020 | 375,640 | SH | DFND | 1 | 375,640 | 0 | 0 | |
| Consolidated Edison | COM | 209115104 | 68 | 950 | SH | DFND | 2 | 950 | 0 | 0 | |
| Consolidated Edison | COM | 209115104 | 2,076 | 28,860 | SH | DFND | 3 | 28,860 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 14,999 | 296,664 | SH | DFND | 1 | 296,664 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 156,834 | 3,101,939 | SH | DFND | 2 | 2,007,926 | 0 | 1,094,013 | |
| Copa Holdings S A | CL A | P31076105 | 38,981 | 770,976 | SH | DFND | 3 | 36,029 | 0 | 734,947 | |
| Copa Holdings S A | CL A | P31076105 | 1,763 | 34,873 | SH | DFND | 4 | 34,873 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 14,047 | 277,829 | SH | SOLE | 0 | 277,829 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 13,493 | 100,946 | SH | DFND | 1 | 100,946 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 200,457 | 1,499,643 | SH | DFND | 2 | 859,251 | 0 | 640,392 | |
| Credicorp | COM | G2519Y108 | 27,004 | 202,020 | SH | DFND | 3 | 10,586 | 0 | 191,434 | |
| Credicorp | COM | G2519Y108 | 1,349 | 10,091 | SH | DFND | 4 | 10,091 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 16,248 | 121,553 | SH | SOLE | 0 | 121,553 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 7,508 | 100,489 | SH | DFND | 1 | 100,489 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 444 | 5,942 | SH | DFND | 2 | 0 | 0 | 5,942 | |
| Cullen/Frost Bankers | COM | 229899109 | 10 | 128 | SH | DFND | 3 | 128 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 9,119 | 122,059 | SH | SOLE | 0 | 122,059 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 16,874 | 169,977 | SH | DFND | 1 | 169,977 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 19,506 | 196,490 | SH | DFND | 2 | 75,966 | 0 | 120,524 | |
| CyberArk Software Ltd | SHS | M2682V108 | 6,168 | 62,133 | SH | DFND | 3 | 62,133 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 7,991 | 80,500 | SH | SOLE | 0 | 80,500 | 0 | 0 | |
| DTE Energy Co | COM | 233331107 | 33,153 | 308,400 | SH | DFND | 1 | 308,400 | 0 | 0 | |
| DTE Energy Co | COM | 233331107 | 75 | 700 | SH | DFND | 2 | 700 | 0 | 0 | |
| DTE Energy Co | COM | 233331107 | 2,156 | 20,055 | SH | DFND | 3 | 20,055 | 0 | 0 | |
| Dada Nexus Ltd ADR | ADS | 23344D108 | 6,359 | 285,176 | SH | DFND | 1 | 285,176 | 0 | 0 | |
| Dada Nexus Ltd ADR | ADS | 23344D108 | 9 | 395 | SH | DFND | 3 | 395 | 0 | 0 | |
| Dada Nexus Ltd ADR | ADS | 23344D108 | 2,183 | 97,906 | SH | SOLE | 0 | 97,906 | 0 | 0 | |
| Deere & Co | COM | 244199105 | 14,157 | 90,083 | SH | DFND | 1 | 90,083 | 0 | 0 | |
| Deere & Co | COM | 244199105 | 4,980 | 31,688 | SH | DFND | 2 | 22,908 | 0 | 8,780 | |
| Deere & Co | COM | 244199105 | 7,847 | 49,932 | SH | DFND | 3 | 19,239 | 0 | 30,693 | |
| Denali Therapeutics | COM | 24823R105 | 50,690 | 2,096,355 | SH | DFND | 1 | 2,096,355 | 0 | 0 | |
| Denali Therapeutics | COM | 24823R105 | 51,689 | 2,137,693 | SH | DFND | 2 | 2,036,391 | 0 | 101,302 | |
| Denali Therapeutics | COM | 24823R105 | 2,958 | 122,313 | SH | DFND | 3 | 90,536 | 0 | 31,777 | |
| Denali Therapeutics | COM | 24823R105 | 119,034 | 4,922,833 | SH | SOLE | 0 | 4,922,833 | 0 | 0 | |
| Dexcom Inc | COM | 252131107 | 236,401 | 583,131 | SH | DFND | 1 | 583,131 | 0 | 0 | |
| Dexcom Inc | COM | 252131107 | 1,119,354 | 2,761,111 | SH | DFND | 2 | 1,046,297 | 0 | 1,714,814 | |
| Dexcom Inc | COM | 252131107 | 124,554 | 307,238 | SH | DFND | 3 | 183,905 | 0 | 123,333 | |
| Dexcom Inc | COM | 252131107 | 361,010 | 890,504 | SH | SOLE | 0 | 472,885 | 0 | 417,619 | |
| Digimarc | COM | 25381B101 | 2,976 | 186,145 | SH | DFND | 1 | 186,145 | 0 | 0 | |
| Digimarc | COM | 25381B101 | 5,094 | 318,584 | SH | DFND | 2 | 123,711 | 0 | 194,873 | |
| Digimarc | COM | 25381B101 | 1,660 | 103,803 | SH | DFND | 3 | 103,803 | 0 | 0 | |
| Digimarc | COM | 25381B101 | 2,474 | 154,711 | SH | SOLE | 0 | 154,711 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 8,632 | 131,044 | SH | DFND | 1 | 131,044 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 455 | 6,904 | SH | DFND | 2 | 0 | 0 | 6,904 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 11 | 170 | SH | DFND | 3 | 170 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 9,380 | 142,400 | SH | SOLE | 0 | 142,400 | 0 | 0 | |
| EOG Resources | COM | 26875P101 | 50,483 | 996,503 | SH | DFND | 1 | 996,503 | 0 | 0 | |
| EOG Resources | COM | 26875P101 | 183,357 | 3,619,370 | SH | DFND | 2 | 3,356,181 | 0 | 263,189 | |
| EOG Resources | COM | 26875P101 | 26,220 | 517,574 | SH | DFND | 3 | 262,738 | 0 | 254,836 | |
| EOG Resources | COM | 26875P101 | 117,506 | 2,319,496 | SH | SOLE | 0 | 2,148,992 | 0 | 170,504 | |
| Ecolab | COM | 278865100 | 15,674 | 78,786 | SH | DFND | 1 | 78,786 | 0 | 0 | |
| Ecolab | COM | 278865100 | 5,481 | 27,551 | SH | DFND | 2 | 19,830 | 0 | 7,721 | |
| Ecolab | COM | 278865100 | 8,669 | 43,572 | SH | DFND | 3 | 16,969 | 0 | 26,603 | |
| Edwards Lifesciences Corp | COM | 28176E108 | 13,029 | 188,523 | SH | DFND | 2 | 188,523 | 0 | 0 | |
| Edwards Lifesciences Corp | COM | 28176E108 | 430 | 6,220 | SH | DFND | 3 | 6,220 | 0 | 0 | |
| Estee Lauder 'A' | COM | 518439104 | 33,510 | 177,600 | SH | DFND | 1 | 177,600 | 0 | 0 | |
| Estee Lauder 'A' | COM | 518439104 | 147,189 | 780,096 | SH | DFND | 2 | 732,878 | 0 | 47,218 | |
| Estee Lauder 'A' | COM | 518439104 | 24,563 | 130,184 | SH | DFND | 3 | 60,952 | 0 | 69,232 | |
| Estee Lauder 'A' | COM | 518439104 | 79,748 | 422,665 | SH | SOLE | 0 | 391,603 | 0 | 31,062 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 11,956 | 1,395,096 | SH | DFND | 1 | 1,395,096 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 12,873 | 1,502,044 | SH | DFND | 2 | 1,439,307 | 0 | 62,737 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 169 | 19,741 | SH | DFND | 3 | 19,741 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 2,628 | 306,658 | SH | SOLE | 0 | 306,658 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 15,678 | 269,567 | SH | DFND | 1 | 269,567 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 14,206 | 244,253 | SH | DFND | 2 | 94,141 | 0 | 150,112 | |
| EverQuote Inc | COM CL A | 30041R108 | 4,458 | 76,643 | SH | DFND | 3 | 76,643 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 8,713 | 149,814 | SH | SOLE | 0 | 149,814 | 0 | 0 | |
| Eversource Energy | COM | 30040W108 | 30,611 | 367,610 | SH | DFND | 1 | 367,610 | 0 | 0 | |
| Eversource Energy | COM | 30040W108 | 77 | 920 | SH | DFND | 2 | 920 | 0 | 0 | |
| Eversource Energy | COM | 30040W108 | 2,156 | 25,889 | SH | DFND | 3 | 25,889 | 0 | 0 | |
| Exact Sciences | COM | 30063P105 | 22,885 | 263,228 | SH | DFND | 1 | 263,228 | 0 | 0 | |
| Exact Sciences | COM | 30063P105 | 29,272 | 336,689 | SH | DFND | 2 | 134,293 | 0 | 202,396 | |
| Exact Sciences | COM | 30063P105 | 11,174 | 128,529 | SH | DFND | 3 | 120,932 | 0 | 7,597 | |
| Exact Sciences | COM | 30063P105 | 14,755 | 169,715 | SH | SOLE | 0 | 169,715 | 0 | 0 | |
| Exelon Corporation | COM | 30161N101 | 704 | 19,387 | SH | DFND | 1 | 19,387 | 0 | 0 | |
| Facebook Cl.A | CL A | 30303M102 | 452,449 | 1,992,555 | SH | DFND | 1 | 1,992,555 | 0 | 0 | |
| Facebook Cl.A | CL A | 30303M102 | 1,909,282 | 8,408,342 | SH | DFND | 2 | 4,595,811 | 0 | 3,812,531 | |
| Facebook Cl.A | CL A | 30303M102 | 198,833 | 875,645 | SH | DFND | 3 | 502,800 | 0 | 372,845 | |
| Facebook Cl.A | CL A | 30303M102 | 755,470 | 3,327,035 | SH | SOLE | 0 | 2,323,336 | 0 | 1,003,699 | |
| Farfetch | ORD SHS CL A | 30744W107 | 4,725 | 273,614 | SH | DFND | 1 | 273,614 | 0 | 0 | |
| Farfetch | ORD SHS CL A | 30744W107 | 1,740 | 100,755 | SH | DFND | 3 | 100,755 | 0 | 0 | |
| Farfetch | ORD SHS CL A | 30744W107 | 33,315 | 1,929,063 | SH | SOLE | 0 | 1,401,206 | 0 | 527,857 | |
| Faro Technologies | COM | 311642102 | 5,452 | 101,715 | SH | DFND | 1 | 101,715 | 0 | 0 | |
| Faro Technologies | COM | 311642102 | 9,528 | 177,757 | SH | DFND | 2 | 68,790 | 0 | 108,967 | |
| Faro Technologies | COM | 311642102 | 3,021 | 56,353 | SH | DFND | 3 | 56,353 | 0 | 0 | |
| Faro Technologies | COM | 311642102 | 5,782 | 107,880 | SH | SOLE | 0 | 107,880 | 0 | 0 | |
| Fastenal | COM | 311900104 | 35,573 | 830,359 | SH | DFND | 1 | 830,359 | 0 | 0 | |
| Fastenal | COM | 311900104 | 19,531 | 455,912 | SH | DFND | 2 | 420,738 | 0 | 35,174 | |
| Fastenal | COM | 311900104 | 3,880 | 90,562 | SH | DFND | 3 | 59,651 | 0 | 30,911 | |
| Fastenal | COM | 311900104 | 34,789 | 812,078 | SH | SOLE | 0 | 812,078 | 0 | 0 | |
| Ferrari NV | COM | N3167Y103 | 1,782,112 | 10,449,188 | SH | DFND | 2 | 8,013,774 | 0 | 2,435,414 | |
| Ferrari NV | COM | N3167Y103 | 341,613 | 2,003,000 | SH | SOLE | 0 | 2,003,000 | 0 | 0 | |
| Fiat Chrysler Automobiles | SHS | N31738102 | 319,426 | 31,798,112 | SH | DFND | 2 | 22,900,522 | 0 | 8,897,590 | |
| First Quantum Minerals | COM | 335934105 | 10,934 | 1,376,311 | SH | DFND | 1 | 1,376,311 | 0 | 0 | |
| First Quantum Minerals | COM | 335934105 | 47,362 | 5,961,845 | SH | DFND | 2 | 4,363,045 | 0 | 1,598,800 | |
| First Republic Bank | COM | 33616C100 | 147,270 | 1,389,473 | SH | DFND | 1 | 1,389,473 | 0 | 0 | |
| First Republic Bank | COM | 33616C100 | 174,155 | 1,643,123 | SH | DFND | 2 | 1,581,679 | 0 | 61,444 | |
| First Republic Bank | COM | 33616C100 | 8,225 | 77,603 | SH | DFND | 3 | 56,794 | 0 | 20,809 | |
| First Republic Bank | COM | 33616C100 | 44,101 | 416,087 | SH | SOLE | 0 | 416,087 | 0 | 0 | |
| Fortis | COM | 349553107 | 714 | 18,837 | SH | DFND | 1 | 18,837 | 0 | 0 | |
| Fortive Corp | COM | 34959J108 | 9,853 | 145,632 | SH | DFND | 2 | 145,632 | 0 | 0 | |
| Glaukos Corp | COM | 377322102 | 70,149 | 1,825,852 | SH | DFND | 1 | 1,825,852 | 0 | 0 | |
| Glaukos Corp | COM | 377322102 | 60,235 | 1,567,793 | SH | DFND | 2 | 1,472,179 | 0 | 95,614 | |
| Glaukos Corp | COM | 377322102 | 7,603 | 197,904 | SH | DFND | 3 | 97,711 | 0 | 100,193 | |
| Glaukos Corp | COM | 377322102 | 16,673 | 433,958 | SH | SOLE | 0 | 433,958 | 0 | 0 | |
| Grifols ADR | SP ADR REP B NVT | 398438408 | 53,063 | 2,909,176 | SH | DFND | 2 | 2,082,966 | 0 | 826,210 | |
| Grifols ADR | SP ADR REP B NVT | 398438408 | 7,049 | 386,447 | SH | SOLE | 0 | 386,447 | 0 | 0 | |
| Grubhub Inc | COM | 400110102 | 55,393 | 787,955 | SH | DFND | 1 | 787,955 | 0 | 0 | |
| Grubhub Inc | COM | 400110102 | 163,313 | 2,323,092 | SH | DFND | 2 | 1,920,220 | 0 | 402,872 | |
| Grubhub Inc | COM | 400110102 | 37,966 | 540,055 | SH | DFND | 3 | 325,073 | 0 | 214,982 | |
| Grubhub Inc | COM | 400110102 | 103,652 | 1,474,430 | SH | SOLE | 0 | 1,373,718 | 0 | 100,712 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 33,046 | 726,918 | SH | DFND | 2 | 627,813 | 0 | 99,105 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 8,185 | 180,044 | SH | DFND | 3 | 79,459 | 0 | 100,585 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 65,011 | 1,430,079 | SH | SOLE | 0 | 1,313,525 | 0 | 116,554 | |
| HEICO | COM | 422806109 | 10,326 | 103,624 | SH | DFND | 1 | 103,624 | 0 | 0 | |
| HEICO | COM | 422806109 | 6,975 | 69,997 | SH | SOLE | 0 | 69,997 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 36,523 | 449,572 | SH | DFND | 1 | 449,572 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 60,487 | 744,552 | SH | DFND | 2 | 716,713 | 0 | 27,839 | |
| HEICO 'A' | CL A | 422806208 | 672 | 8,273 | SH | DFND | 3 | 8,273 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 6,699 | 82,462 | SH | SOLE | 0 | 82,462 | 0 | 0 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 14,274 | 764,522 | SH | DFND | 1 | 764,522 | 0 | 0 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 7,190 | 385,134 | SH | DFND | 3 | 370 | 0 | 384,764 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 7,384 | 395,495 | SH | SOLE | 0 | 395,495 | 0 | 0 | |
| Health Catalyst Inc | COM | 42225T107 | 175 | 5,987 | SH | DFND | 3 | 5,987 | 0 | 0 | |
| Howard Hughes | COM | 44267D107 | 24,299 | 467,734 | SH | DFND | 1 | 467,734 | 0 | 0 | |
| Howard Hughes | COM | 44267D107 | 81,583 | 1,570,407 | SH | DFND | 2 | 1,449,763 | 0 | 120,644 | |
| Howard Hughes | COM | 44267D107 | 17,253 | 332,100 | SH | DFND | 3 | 156,310 | 0 | 175,790 | |
| Howard Hughes | COM | 44267D107 | 55,753 | 1,073,202 | SH | SOLE | 0 | 996,275 | 0 | 76,927 | |
| Hutchison China Meditech | SPONSORED ADR | 44842L103 | 990 | 35,894 | SH | DFND | 1 | 35,894 | 0 | 0 | |
| Hutchison China Meditech | SPONSORED ADR | 44842L103 | 5,272 | 191,146 | SH | DFND | 3 | 0 | 0 | 191,146 | |
| ICICI Bank ADR | ADR | 45104G104 | 66,159 | 7,121,491 | SH | DFND | 1 | 7,121,491 | 0 | 0 | |
| ICICI Bank ADR | ADR | 45104G104 | 61,970 | 6,670,653 | SH | DFND | 2 | 5,926,833 | 0 | 743,820 | |
| ICICI Bank ADR | ADR | 45104G104 | 34,821 | 3,748,252 | SH | DFND | 3 | 1,846,411 | 0 | 1,901,841 | |
| ICICI Bank ADR | ADR | 45104G104 | 5,014 | 539,749 | SH | DFND | 4 | 539,749 | 0 | 0 | |
| ICICI Bank ADR | ADR | 45104G104 | 89,334 | 9,616,198 | SH | SOLE | 0 | 9,055,844 | 0 | 560,354 | |
| IPG Photonics Corp | COM | 44980X109 | 15,597 | 97,247 | SH | DFND | 1 | 97,247 | 0 | 0 | |
| IPG Photonics Corp | COM | 44980X109 | 18,583 | 115,860 | SH | DFND | 2 | 44,973 | 0 | 70,887 | |
| IPG Photonics Corp | COM | 44980X109 | 5,903 | 36,807 | SH | DFND | 3 | 36,807 | 0 | 0 | |
| IPG Photonics Corp | COM | 44980X109 | 11,810 | 73,636 | SH | SOLE | 0 | 73,636 | 0 | 0 | |
| Iclick Interactive Asia G | SPON ADR | 45113Y104 | 9,234 | 1,732,466 | SH | DFND | 1 | 1,732,466 | 0 | 0 | |
| Iclick Interactive Asia G | SPON ADR | 45113Y104 | 12 | 2,288 | SH | DFND | 3 | 2,288 | 0 | 0 | |
| Iclick Interactive Asia G | SPON ADR | 45113Y104 | 3,000 | 562,765 | SH | SOLE | 0 | 562,765 | 0 | 0 | |
| Illumina | COM | 452327109 | 639,989 | 1,728,064 | SH | DFND | 1 | 1,728,064 | 0 | 0 | |
| Illumina | COM | 452327109 | 3,640,442 | 9,829,735 | SH | DFND | 2 | 6,217,256 | 0 | 3,612,479 | |
| Illumina | COM | 452327109 | 245,102 | 661,813 | SH | DFND | 3 | 390,764 | 0 | 271,049 | |
| Illumina | COM | 452327109 | 1,811,198 | 4,890,503 | SH | SOLE | 0 | 4,039,820 | 0 | 850,683 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 8,914 | 922,731 | SH | DFND | 1 | 922,731 | 0 | 0 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 2,854 | 295,452 | SH | DFND | 2 | 208,166 | 0 | 87,286 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 3,163 | 327,435 | SH | DFND | 3 | 205,018 | 0 | 122,417 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 1,840 | 190,455 | SH | DFND | 4 | 190,455 | 0 | 0 | |
| Interactive Brokers Group | COM | 45841N107 | 73,430 | 1,757,969 | SH | DFND | 1 | 1,757,969 | 0 | 0 | |
| Interactive Brokers Group | COM | 45841N107 | 135,463 | 3,243,071 | SH | DFND | 2 | 3,048,010 | 0 | 195,061 | |
| Interactive Brokers Group | COM | 45841N107 | 20,693 | 495,407 | SH | DFND | 3 | 258,611 | 0 | 236,796 | |
| Interactive Brokers Group | COM | 45841N107 | 69,091 | 1,654,076 | SH | SOLE | 0 | 1,558,617 | 0 | 95,459 | |
| Intuitive Surgical | COM NEW | 46120E602 | 99,015 | 173,763 | SH | DFND | 1 | 173,763 | 0 | 0 | |
| Intuitive Surgical | COM NEW | 46120E602 | 656,329 | 1,151,798 | SH | DFND | 2 | 429,833 | 0 | 721,965 | |
| Intuitive Surgical | COM NEW | 46120E602 | 53,072 | 93,137 | SH | DFND | 3 | 60,628 | 0 | 32,509 | |
| Intuitive Surgical | COM NEW | 46120E602 | 351,081 | 616,116 | SH | SOLE | 0 | 436,135 | 0 | 179,981 | |
| Invesco Senior Income Trust | COM | 46131H107 | 7,589 | 2,193,291 | SH | DFND | 1 | 2,193,291 | 0 | 0 | |
| Invesco Senior Income Trust | COM | 46131H107 | 2,210 | 638,746 | SH | DFND | 3 | 638,746 | 0 | 0 | |
| Ionis Pharmaceuticals | COM | 462222100 | 48,360 | 820,220 | SH | DFND | 1 | 820,220 | 0 | 0 | |
| Ionis Pharmaceuticals | COM | 462222100 | 310,589 | 5,267,790 | SH | DFND | 2 | 1,972,096 | 0 | 3,295,694 | |
| Ionis Pharmaceuticals | COM | 462222100 | 25,491 | 432,339 | SH | DFND | 3 | 283,108 | 0 | 149,231 | |
| Ionis Pharmaceuticals | COM | 462222100 | 100,135 | 1,698,350 | SH | SOLE | 0 | 870,812 | 0 | 827,538 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 11,140 | 2,375,333 | SH | DFND | 1 | 2,375,333 | 0 | 0 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 113,266 | 24,150,436 | SH | DFND | 2 | 12,850,904 | 0 | 11,299,532 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 57,220 | 12,200,385 | SH | DFND | 3 | 519,583 | 0 | 11,680,802 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 2,313 | 493,153 | SH | DFND | 4 | 493,153 | 0 | 0 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 9,842 | 2,098,498 | SH | SOLE | 0 | 2,098,498 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 126,392 | 2,100,240 | SH | DFND | 1 | 2,100,240 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 174,524 | 2,900,033 | SH | DFND | 2 | 959,025 | 0 | 1,941,008 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 111,452 | 1,851,982 | SH | DFND | 3 | 199,849 | 0 | 1,652,133 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 4,984 | 82,826 | SH | DFND | 4 | 82,826 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 22,256 | 369,831 | SH | SOLE | 0 | 369,831 | 0 | 0 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 26,940 | 1,732,474 | SH | DFND | 1 | 1,732,474 | 0 | 0 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 89,862 | 5,778,931 | SH | DFND | 2 | 5,312,699 | 0 | 466,232 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 18,836 | 1,211,305 | SH | DFND | 3 | 553,145 | 0 | 658,160 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 64,200 | 4,128,607 | SH | SOLE | 0 | 3,830,369 | 0 | 298,238 | |
| Jianpu Technology Inc- ADR | ADR | 47738D101 | 304 | 467,034 | SH | DFND | 1 | 467,034 | 0 | 0 | |
| Jianpu Technology Inc- ADR | ADR | 47738D101 | 264 | 406,185 | SH | SOLE | 0 | 406,185 | 0 | 0 | |
| Jumia Technologies Ag ADR | SPONSORED ADS | 48138M105 | 50,728 | 9,240,132 | SH | DFND | 2 | 8,957,519 | 0 | 282,613 | |
| Kaleido Biosciences Inc | COM | 483347100 | 1,831 | 246,500 | SH | DFND | 1 | 246,500 | 0 | 0 | |
| Kaleido Biosciences Inc | COM | 483347100 | 1,438 | 193,500 | SH | SOLE | 0 | 193,500 | 0 | 0 | |
| Kirby | COM | 497266106 | 51,464 | 960,871 | SH | DFND | 1 | 960,871 | 0 | 0 | |
| Kirby | COM | 497266106 | 178,556 | 3,333,760 | SH | DFND | 2 | 3,079,943 | 0 | 253,817 | |
| Kirby | COM | 497266106 | 37,949 | 708,537 | SH | DFND | 3 | 332,360 | 0 | 376,177 | |
| Kirby | COM | 497266106 | 122,389 | 2,285,087 | SH | SOLE | 0 | 2,114,436 | 0 | 170,651 | |
| Korea Electric Power ADR | SPONSORED ADR | 500631106 | 15 | 1,900 | SH | DFND | 2 | 1,900 | 0 | 0 | |
| Korea Electric Power ADR | SPONSORED ADR | 500631106 | 1,214 | 152,080 | SH | DFND | 3 | 152,080 | 0 | 0 | |
| LendingTree | COM | 52603B107 | 75,389 | 260,384 | SH | DFND | 1 | 260,384 | 0 | 0 | |
| LendingTree | COM | 52603B107 | 170,636 | 589,354 | SH | DFND | 2 | 427,417 | 0 | 161,937 | |
| LendingTree | COM | 52603B107 | 46,745 | 161,450 | SH | DFND | 3 | 115,036 | 0 | 46,414 | |
| LendingTree | COM | 52603B107 | 104,379 | 360,513 | SH | SOLE | 0 | 342,197 | 0 | 18,316 | |
| Lindblad Expeditions Holdings | COM | 535219109 | 5,404 | 700,000 | SH | SOLE | 0 | 700,000 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 13,965 | 328,822 | SH | DFND | 1 | 328,822 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 13,782 | 324,518 | SH | DFND | 2 | 124,931 | 0 | 199,587 | |
| Liveramp Holdings Inc | COM | 53815P108 | 4,358 | 102,605 | SH | DFND | 3 | 102,605 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 7,882 | 185,600 | SH | SOLE | 0 | 185,600 | 0 | 0 | |
| Livongo Health Inc | COM | 539183103 | 116 | 1,548 | SH | DFND | 3 | 1,548 | 0 | 0 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 57,962 | 1,755,880 | SH | DFND | 1 | 1,755,880 | 0 | 0 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 142,814 | 4,326,400 | SH | DFND | 2 | 4,028,286 | 0 | 298,114 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 25,397 | 769,367 | SH | DFND | 3 | 368,915 | 0 | 400,452 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 136,750 | 4,142,682 | SH | SOLE | 0 | 3,969,497 | 0 | 173,185 | |
| M&T Bank | COM | 55261F104 | 8,794 | 84,580 | SH | DFND | 2 | 84,580 | 0 | 0 | |
| MRC Global | COM | 55345K103 | 3,841 | 650,000 | SH | SOLE | 0 | 650,000 | 0 | 0 | |
| MakeMyTrip | SHS | V5633W109 | 49,509 | 3,231,669 | SH | DFND | 2 | 2,522,443 | 0 | 709,226 | |
| Markel Corp | COM | 570535104 | 55,850 | 60,498 | SH | DFND | 1 | 60,498 | 0 | 0 | |
| Markel Corp | COM | 570535104 | 191,288 | 207,208 | SH | DFND | 2 | 192,496 | 0 | 14,712 | |
| Markel Corp | COM | 570535104 | 40,356 | 43,715 | SH | DFND | 3 | 20,780 | 0 | 22,935 | |
| Markel Corp | COM | 570535104 | 126,823 | 137,378 | SH | SOLE | 0 | 127,534 | 0 | 9,844 | |
| MarketAxess Holdings | COM | 57060D108 | 363,576 | 725,817 | SH | DFND | 1 | 725,817 | 0 | 0 | |
| MarketAxess Holdings | COM | 57060D108 | 444,159 | 886,686 | SH | DFND | 2 | 743,358 | 0 | 143,328 | |
| MarketAxess Holdings | COM | 57060D108 | 48,434 | 96,690 | SH | DFND | 3 | 85,996 | 0 | 10,694 | |
| MarketAxess Holdings | COM | 57060D108 | 151,589 | 302,622 | SH | SOLE | 0 | 302,622 | 0 | 0 | |
| Martin Marietta Materials | COM | 573284106 | 75,929 | 367,571 | SH | DFND | 1 | 367,571 | 0 | 0 | |
| Martin Marietta Materials | COM | 573284106 | 258,251 | 1,250,187 | SH | DFND | 2 | 1,157,813 | 0 | 92,374 | |
| Martin Marietta Materials | COM | 573284106 | 52,741 | 255,317 | SH | DFND | 3 | 118,519 | 0 | 136,798 | |
| Martin Marietta Materials | COM | 573284106 | 180,277 | 872,716 | SH | SOLE | 0 | 811,338 | 0 | 61,378 | |
| Masimo Corp | COM | 574795100 | 299 | 1,311 | SH | DFND | 3 | 1,311 | 0 | 0 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 372,929 | 1,261,173 | SH | DFND | 1 | 1,261,173 | 0 | 0 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 813,473 | 2,751,008 | SH | DFND | 2 | 2,575,318 | 0 | 175,690 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 125,369 | 423,972 | SH | DFND | 3 | 206,513 | 0 | 217,459 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 437,751 | 1,480,390 | SH | SOLE | 0 | 1,385,106 | 0 | 95,284 | |
| McDonald's | COM | 580135101 | 15,010 | 81,369 | SH | DFND | 1 | 81,369 | 0 | 0 | |
| McDonald's | COM | 580135101 | 797 | 4,322 | SH | DFND | 2 | 0 | 0 | 4,322 | |
| McDonald's | COM | 580135101 | 19 | 103 | SH | DFND | 3 | 103 | 0 | 0 | |
| McDonald's | COM | 580135101 | 16,317 | 88,451 | SH | SOLE | 0 | 88,451 | 0 | 0 | |
| Medtronic | COM | G5960L903 | 8,835 | 96,352 | SH | DFND | 1 | 96,352 | 0 | 0 | |
| Medtronic | COM | G5960L903 | 367 | 4,000 | SH | DFND | 2 | 0 | 0 | 4,000 | |
| Medtronic | COM | G5960L903 | 11 | 124 | SH | DFND | 3 | 124 | 0 | 0 | |
| Medtronic | COM | G5960L903 | 9,636 | 105,077 | SH | SOLE | 0 | 105,077 | 0 | 0 | |
| Menlo Therapeutics Inc | COM | 586858102 | 337 | 194,824 | SH | DFND | 1 | 194,824 | 0 | 0 | |
| Menlo Therapeutics Inc | COM | 586858102 | 346 | 200,225 | SH | SOLE | 0 | 200,225 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 204,295 | 207,244 | SH | DFND | 1 | 207,244 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 4,176,499 | 4,236,788 | SH | DFND | 2 | 3,403,294 | 0 | 833,494 | |
| MercadoLibre | COM | 58733R102 | 42,095 | 42,703 | SH | DFND | 3 | 30,240 | 0 | 12,463 | |
| MercadoLibre | COM | 58733R102 | 9,345 | 9,480 | SH | DFND | 4 | 9,480 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 300,248 | 304,582 | SH | SOLE | 0 | 304,582 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 52,377 | 65,020 | SH | DFND | 1 | 65,020 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 392,139 | 486,796 | SH | DFND | 2 | 345,448 | 0 | 141,348 | |
| Mettler-Toledo | COM | 592688105 | 1,680 | 2,085 | SH | DFND | 3 | 2,085 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 24,674 | 30,630 | SH | SOLE | 0 | 30,630 | 0 | 0 | |
| Microsoft | COM | 594918104 | 210,154 | 1,032,649 | SH | DFND | 1 | 1,032,649 | 0 | 0 | |
| Microsoft | COM | 594918104 | 676,623 | 3,324,765 | SH | DFND | 2 | 3,093,194 | 0 | 231,571 | |
| Microsoft | COM | 594918104 | 127,742 | 627,696 | SH | DFND | 3 | 292,701 | 0 | 334,995 | |
| Microsoft | COM | 594918104 | 442,885 | 2,176,234 | SH | SOLE | 0 | 2,028,205 | 0 | 148,029 | |
| Mobile Telesystems ADR | SPONSORED ADR | 607409109 | 273 | 29,700 | SH | DFND | 1 | 29,700 | 0 | 0 | |
| Moderna Inc | COM | 60770K107 | 120,945 | 1,883,590 | SH | DFND | 1 | 1,883,590 | 0 | 0 | |
| Moderna Inc | COM | 60770K107 | 95,836 | 1,492,536 | SH | DFND | 2 | 1,382,577 | 0 | 109,959 | |
| Moderna Inc | COM | 60770K107 | 19,195 | 298,947 | SH | DFND | 3 | 133,749 | 0 | 165,198 | |
| Moderna Inc | COM | 60770K107 | 24,683 | 384,410 | SH | SOLE | 0 | 384,410 | 0 | 0 | |
| Moody's Corp | COM | 615369105 | 209,486 | 762,517 | SH | DFND | 1 | 762,517 | 0 | 0 | |
| Moody's Corp | COM | 615369105 | 723,253 | 2,632,594 | SH | DFND | 2 | 2,440,116 | 0 | 192,478 | |
| Moody's Corp | COM | 615369105 | 147,028 | 535,174 | SH | DFND | 3 | 248,599 | 0 | 286,575 | |
| Moody's Corp | COM | 615369105 | 471,136 | 1,714,906 | SH | SOLE | 0 | 1,587,089 | 0 | 127,817 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 34,907 | 4,521,662 | SH | DFND | 1 | 4,521,662 | 0 | 0 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 456,835 | 59,175,575 | SH | DFND | 2 | 37,623,120 | 0 | 21,552,455 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 18,131 | 2,348,535 | SH | DFND | 3 | 1,529,794 | 0 | 818,741 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 244,970 | 31,731,822 | SH | SOLE | 0 | 27,262,851 | 0 | 4,468,971 | |
| NVIDIA | COM | 67066G104 | 237,271 | 624,544 | SH | DFND | 1 | 624,544 | 0 | 0 | |
| NVIDIA | COM | 67066G104 | 1,103,221 | 2,903,900 | SH | DFND | 2 | 1,285,609 | 0 | 1,618,291 | |
| NVIDIA | COM | 67066G104 | 81,115 | 213,512 | SH | DFND | 3 | 139,546 | 0 | 73,966 | |
| NVIDIA | COM | 67066G104 | 658,771 | 1,734,019 | SH | SOLE | 0 | 1,352,025 | 0 | 381,994 | |
| National Instruments Corp | COM | 636518102 | 13,594 | 351,169 | SH | DFND | 1 | 351,169 | 0 | 0 | |
| National Instruments Corp | COM | 636518102 | 6,846 | 176,846 | SH | DFND | 2 | 64,088 | 0 | 112,758 | |
| National Instruments Corp | COM | 636518102 | 2,024 | 52,280 | SH | DFND | 3 | 52,280 | 0 | 0 | |
| National Instruments Corp | COM | 636518102 | 14,384 | 371,572 | SH | SOLE | 0 | 371,572 | 0 | 0 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 91,686 | 213,532 | SH | DFND | 1 | 213,532 | 0 | 0 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 552,195 | 1,286,028 | SH | DFND | 2 | 474,827 | 0 | 811,201 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 45,636 | 106,284 | SH | DFND | 3 | 69,189 | 0 | 37,095 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 180,787 | 421,043 | SH | SOLE | 0 | 216,296 | 0 | 204,747 | |
| Netflix Inc | COM | 64110L106 | 568,592 | 1,249,542 | SH | DFND | 1 | 1,249,542 | 0 | 0 | |
| Netflix Inc | COM | 64110L106 | 1,749,612 | 3,844,963 | SH | DFND | 2 | 2,103,527 | 0 | 1,741,436 | |
| Netflix Inc | COM | 64110L106 | 153,294 | 336,880 | SH | DFND | 3 | 207,519 | 0 | 129,361 | |
| Netflix Inc | COM | 64110L106 | 1,038,447 | 2,282,100 | SH | SOLE | 0 | 1,842,439 | 0 | 439,661 | |
| Newmont Mining | COM | 651639106 | 198 | 3,200 | SH | DFND | 2 | 3,200 | 0 | 0 | |
| NextEra Energy | COM | 65339F101 | 724 | 3,014 | SH | DFND | 1 | 3,014 | 0 | 0 | |
| Novocure Ltd | ORD SHS | G6674U108 | 134,826 | 2,273,619 | SH | DFND | 1 | 2,273,619 | 0 | 0 | |
| Novocure Ltd | ORD SHS | G6674U108 | 204,561 | 3,449,587 | SH | DFND | 2 | 3,014,011 | 0 | 435,576 | |
| Novocure Ltd | ORD SHS | G6674U108 | 28,390 | 478,746 | SH | DFND | 3 | 306,890 | 0 | 171,856 | |
| Novocure Ltd | ORD SHS | G6674U108 | 100,915 | 1,701,768 | SH | SOLE | 0 | 1,625,137 | 0 | 76,631 | |
| Now Inc/DE | COM | 67011P100 | 10,528 | 1,219,984 | SH | DFND | 1 | 1,219,984 | 0 | 0 | |
| Now Inc/DE | COM | 67011P100 | 40,916 | 4,741,131 | SH | DFND | 2 | 4,395,783 | 0 | 345,348 | |
| Now Inc/DE | COM | 67011P100 | 7,522 | 871,593 | SH | DFND | 3 | 438,320 | 0 | 433,273 | |
| Now Inc/DE | COM | 67011P100 | 30,850 | 3,574,713 | SH | SOLE | 0 | 3,356,385 | 0 | 218,328 | |
| Nucana Plc ADR | SPONSORED ADR | 67022C106 | 2,653 | 491,208 | SH | DFND | 1 | 491,208 | 0 | 0 | |
| Nucana Plc ADR | SPONSORED ADR | 67022C106 | 1,815 | 336,100 | SH | SOLE | 0 | 336,100 | 0 | 0 | |
| Nuveen Senior Income Fund | COM | 67067Y104 | 1,763 | 375,012 | SH | DFND | 1 | 375,012 | 0 | 0 | |
| Orchard Therapeutics PLC ADR | ADS | 68570P101 | 16,440 | 2,740,000 | SH | SOLE | 0 | 2,740,000 | 0 | 0 | |
| Pacira BioSciences | COM | 695127100 | 25,371 | 483,526 | SH | DFND | 1 | 483,526 | 0 | 0 | |
| Pacira BioSciences | COM | 695127100 | 24,197 | 461,164 | SH | DFND | 2 | 191,880 | 0 | 269,284 | |
| Pacira BioSciences | COM | 695127100 | 10,823 | 206,271 | SH | DFND | 3 | 182,789 | 0 | 23,482 | |
| Pacira BioSciences | COM | 695127100 | 16,196 | 308,665 | SH | SOLE | 0 | 308,665 | 0 | 0 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 95,256 | 1,648,892 | SH | DFND | 1 | 1,648,892 | 0 | 0 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 631,275 | 10,927,376 | SH | DFND | 2 | 4,091,954 | 0 | 6,835,422 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 51,383 | 889,449 | SH | DFND | 3 | 579,293 | 0 | 310,156 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 204,989 | 3,548,357 | SH | SOLE | 0 | 1,825,735 | 0 | 1,722,622 | |
| Penumbra Inc | COM | 70975L107 | 80,292 | 449,010 | SH | DFND | 1 | 449,010 | 0 | 0 | |
| Penumbra Inc | COM | 70975L107 | 79,369 | 443,846 | SH | DFND | 2 | 423,641 | 0 | 20,205 | |
| Penumbra Inc | COM | 70975L107 | 1,541 | 8,618 | SH | DFND | 3 | 8,618 | 0 | 0 | |
| Penumbra Inc | COM | 70975L107 | 23,053 | 128,919 | SH | SOLE | 0 | 128,919 | 0 | 0 | |
| Pepsico | COM | 713448108 | 25,050 | 189,396 | SH | DFND | 1 | 189,396 | 0 | 0 | |
| Pepsico | COM | 713448108 | 1,240 | 9,378 | SH | DFND | 2 | 0 | 0 | 9,378 | |
| Pepsico | COM | 713448108 | 32 | 239 | SH | DFND | 3 | 239 | 0 | 0 | |
| Pepsico | COM | 713448108 | 26,753 | 202,273 | SH | SOLE | 0 | 202,273 | 0 | 0 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 52,062 | 6,295,234 | SH | DFND | 1 | 6,295,234 | 0 | 0 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 236,780 | 28,631,161 | SH | DFND | 2 | 10,721,665 | 0 | 17,909,496 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 8,357 | 1,010,506 | SH | SOLE | 0 | 1,010,506 | 0 | 0 | |
| Petrobras Pref ADR | SP ADR NON VTG | 71654V101 | 9,833 | 1,233,706 | SH | DFND | 1 | 1,233,706 | 0 | 0 | |
| Petrobras Pref ADR | SP ADR NON VTG | 71654V101 | 65,007 | 8,156,457 | SH | DFND | 2 | 3,885,823 | 0 | 4,270,634 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 199,828 | 2,327,910 | SH | DFND | 1 | 2,327,910 | 0 | 0 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 1,300,682 | 15,152,400 | SH | DFND | 2 | 5,573,194 | 0 | 9,579,206 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 107,789 | 1,255,700 | SH | DFND | 3 | 823,021 | 0 | 432,679 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 604,925 | 7,047,117 | SH | SOLE | 0 | 4,644,117 | 0 | 2,403,000 | |
| Procter & Gamble | COM | 742718109 | 29,578 | 247,371 | SH | DFND | 1 | 247,371 | 0 | 0 | |
| Procter & Gamble | COM | 742718109 | 1,494 | 12,492 | SH | DFND | 2 | 0 | 0 | 12,492 | |
| Procter & Gamble | COM | 742718109 | 38 | 315 | SH | DFND | 3 | 315 | 0 | 0 | |
| Procter & Gamble | COM | 742718109 | 32,081 | 268,299 | SH | SOLE | 0 | 268,299 | 0 | 0 | |
| Q2 Holdings Inc | COM | 74736L109 | 8,893 | 103,658 | SH | DFND | 1 | 103,658 | 0 | 0 | |
| Q2 Holdings Inc | COM | 74736L109 | 11,080 | 129,147 | SH | DFND | 2 | 49,438 | 0 | 79,709 | |
| Q2 Holdings Inc | COM | 74736L109 | 3,510 | 40,910 | SH | DFND | 3 | 40,910 | 0 | 0 | |
| Q2 Holdings Inc | COM | 74736L109 | 6,962 | 81,146 | SH | SOLE | 0 | 81,146 | 0 | 0 | |
| Redfin | COM | 75737F108 | 145,769 | 3,478,136 | SH | DFND | 1 | 3,478,136 | 0 | 0 | |
| Redfin | COM | 75737F108 | 144,024 | 3,436,502 | SH | DFND | 2 | 3,277,155 | 0 | 159,347 | |
| Redfin | COM | 75737F108 | 7,635 | 182,184 | SH | DFND | 3 | 135,495 | 0 | 46,689 | |
| Redfin | COM | 75737F108 | 43,369 | 1,034,813 | SH | SOLE | 0 | 1,034,813 | 0 | 0 | |
| ResMed | COM | 761152107 | 118,081 | 615,003 | SH | DFND | 1 | 615,003 | 0 | 0 | |
| ResMed | COM | 761152107 | 397,925 | 2,072,526 | SH | DFND | 2 | 1,915,168 | 0 | 157,358 | |
| ResMed | COM | 761152107 | 84,070 | 437,864 | SH | DFND | 3 | 205,137 | 0 | 232,727 | |
| ResMed | COM | 761152107 | 273,364 | 1,423,769 | SH | SOLE | 0 | 1,320,142 | 0 | 103,627 | |
| ResTORbio Inc | COM | 76133L103 | 1,406 | 654,147 | SH | DFND | 1 | 654,147 | 0 | 0 | |
| ResTORbio Inc | COM | 76133L103 | 1,327 | 617,240 | SH | SOLE | 0 | 617,240 | 0 | 0 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 36,422 | 891,597 | SH | DFND | 1 | 891,597 | 0 | 0 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 206,129 | 5,046,004 | SH | DFND | 2 | 4,442,769 | 0 | 603,235 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 26,930 | 659,236 | SH | DFND | 3 | 313,739 | 0 | 345,497 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 85,329 | 2,088,827 | SH | SOLE | 0 | 1,933,097 | 0 | 155,730 | |
| Ritchie Bros. Auctioneers | COM | 767744105 | 51,361 | 1,265,672 | SH | DFND | 2 | 710,568 | 0 | 555,104 | |
| Ritchie Bros. Auctioneers | COM | 767744105 | 17,609 | 433,928 | SH | SOLE | 0 | 433,928 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 122,534 | 1,051,521 | SH | DFND | 1 | 1,051,521 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 123,805 | 1,062,426 | SH | DFND | 2 | 1,012,503 | 0 | 49,923 | |
| Roku | COM CL A | 77543R102 | 1,770 | 15,190 | SH | DFND | 3 | 15,190 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 34,848 | 299,045 | SH | SOLE | 0 | 299,045 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 2,696 | 450,800 | SH | DFND | 1 | 450,800 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 989 | 165,310 | SH | DFND | 2 | 70,263 | 0 | 95,047 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 353 | 59,057 | SH | DFND | 3 | 59,057 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 21,406 | 3,579,565 | SH | SOLE | 0 | 3,579,565 | 0 | 0 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 486,437 | 7,332,485 | SH | DFND | 2 | 5,820,418 | 0 | 1,512,067 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 3,019 | 45,508 | SH | DFND | 3 | 6,593 | 0 | 38,915 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 3,128 | 47,149 | SH | SOLE | 0 | 47,149 | 0 | 0 | |
| S&P Global Inc | COM | 78409V104 | 34,102 | 103,501 | SH | DFND | 1 | 103,501 | 0 | 0 | |
| S&P Global Inc | COM | 78409V104 | 138,277 | 419,684 | SH | DFND | 2 | 379,842 | 0 | 39,842 | |
| S&P Global Inc | COM | 78409V104 | 24,784 | 75,222 | SH | DFND | 3 | 35,358 | 0 | 39,864 | |
| S&P Global Inc | COM | 78409V104 | 80,164 | 243,305 | SH | SOLE | 0 | 225,420 | 0 | 17,885 | |
| SEA Ltd ADR | ADR | 81141R100 | 198,826 | 1,854,031 | SH | DFND | 1 | 1,854,031 | 0 | 0 | |
| SEA Ltd ADR | ADR | 81141R100 | 401,249 | 3,741,598 | SH | DFND | 2 | 2,653,125 | 0 | 1,088,473 | |
| SEA Ltd ADR | ADR | 81141R100 | 67,337 | 627,906 | SH | DFND | 3 | 295,244 | 0 | 332,662 | |
| SEA Ltd ADR | ADR | 81141R100 | 264,010 | 2,461,863 | SH | SOLE | 0 | 2,312,744 | 0 | 149,119 | |
| SINA Corp | ORD | G81477104 | 4,724 | 131,550 | SH | DFND | 3 | 0 | 0 | 131,550 | |
| Sage Therapeutics Inc | COM | 78667J108 | 66 | 1,590 | SH | DFND | 3 | 1,590 | 0 | 0 | |
| Salesforce.com | COM | 79466L302 | 93,480 | 499,012 | SH | DFND | 1 | 499,012 | 0 | 0 | |
| Salesforce.com | COM | 79466L302 | 624,980 | 3,336,250 | SH | DFND | 2 | 1,313,338 | 0 | 2,022,912 | |
| Salesforce.com | COM | 79466L302 | 49,145 | 262,347 | SH | DFND | 3 | 171,009 | 0 | 91,338 | |
| Salesforce.com | COM | 79466L302 | 195,834 | 1,045,397 | SH | SOLE | 0 | 538,616 | 0 | 506,781 | |
| Schlumberger | COM | 806857108 | 1,829 | 99,477 | SH | DFND | 2 | 99,477 | 0 | 0 | |
| Seattle Genetics | COM | 812578102 | 83,425 | 490,968 | SH | DFND | 1 | 490,968 | 0 | 0 | |
| Seattle Genetics | COM | 812578102 | 258,183 | 1,519,441 | SH | DFND | 2 | 1,360,597 | 0 | 158,844 | |
| Seattle Genetics | COM | 812578102 | 55,736 | 328,015 | SH | DFND | 3 | 166,703 | 0 | 161,312 | |
| Seattle Genetics | COM | 812578102 | 177,428 | 1,044,185 | SH | SOLE | 0 | 971,706 | 0 | 72,479 | |
| Service Corp.Intl. | COM | 817565104 | 59,178 | 1,521,671 | SH | DFND | 1 | 1,521,671 | 0 | 0 | |
| Service Corp.Intl. | COM | 817565104 | 198,845 | 5,113,023 | SH | DFND | 2 | 4,723,624 | 0 | 389,399 | |
| Service Corp.Intl. | COM | 817565104 | 41,402 | 1,064,593 | SH | DFND | 3 | 487,502 | 0 | 577,091 | |
| Service Corp.Intl. | COM | 817565104 | 136,429 | 3,508,064 | SH | SOLE | 0 | 3,247,516 | 0 | 260,548 | |
| Sherwin-Williams Co | COM | 824348106 | 11,025 | 19,079 | SH | DFND | 2 | 19,079 | 0 | 0 | |
| ShockWave Medical Inc | COM | 82489T104 | 5,048 | 106,572 | SH | DFND | 1 | 106,572 | 0 | 0 | |
| ShockWave Medical Inc | COM | 82489T104 | 6,452 | 136,207 | SH | DFND | 2 | 52,903 | 0 | 83,304 | |
| ShockWave Medical Inc | COM | 82489T104 | 2,250 | 47,507 | SH | DFND | 3 | 47,507 | 0 | 0 | |
| ShockWave Medical Inc | COM | 82489T104 | 4,069 | 85,892 | SH | SOLE | 0 | 85,892 | 0 | 0 | |
| Shopify 'A' | CL A | 82509L107 | 1,046,194 | 1,102,185 | SH | DFND | 1 | 1,102,185 | 0 | 0 | |
| Shopify 'A' | CL A | 82509L107 | 3,029,364 | 3,191,492 | SH | DFND | 2 | 2,244,039 | 0 | 947,453 | |
| Shopify 'A' | CL A | 82509L107 | 250,762 | 264,182 | SH | DFND | 3 | 150,031 | 0 | 114,151 | |
| Shopify 'A' | CL A | 82509L107 | 1,189,103 | 1,252,742 | SH | SOLE | 0 | 1,034,511 | 0 | 218,231 | |
| SiteOne Landscape Supply | COM | 82982L103 | 60,241 | 528,572 | SH | DFND | 1 | 528,572 | 0 | 0 | |
| SiteOne Landscape Supply | COM | 82982L103 | 198,112 | 1,738,282 | SH | DFND | 2 | 1,604,464 | 0 | 133,818 | |
| SiteOne Landscape Supply | COM | 82982L103 | 41,170 | 361,233 | SH | DFND | 3 | 166,923 | 0 | 194,310 | |
| SiteOne Landscape Supply | COM | 82982L103 | 134,893 | 1,183,584 | SH | SOLE | 0 | 1,098,169 | 0 | 85,415 | |
| Slack Technologies Inc | COM CL A | 83088V102 | 90,642 | 2,915,461 | SH | DFND | 1 | 2,915,461 | 0 | 0 | |
| Slack Technologies Inc | COM CL A | 83088V102 | 101,084 | 3,251,323 | SH | DFND | 2 | 3,109,736 | 0 | 141,587 | |
| Slack Technologies Inc | COM CL A | 83088V102 | 4,225 | 135,883 | SH | DFND | 3 | 102,413 | 0 | 33,470 | |
| Slack Technologies Inc | COM CL A | 83088V102 | 56,339 | 1,812,141 | SH | SOLE | 0 | 1,812,141 | 0 | 0 | |
| Snap Inc | CL A | 83304A106 | 4,349 | 185,160 | SH | DFND | 2 | 185,160 | 0 | 0 | |
| Sohu.com | COM | 83410S108 | 1,843 | 200,140 | SH | DFND | 3 | 0 | 0 | 200,140 | |
| Splunk Inc | COM | 848637104 | 20,057 | 100,940 | SH | DFND | 1 | 100,940 | 0 | 0 | |
| Splunk Inc | COM | 848637104 | 30,351 | 152,749 | SH | DFND | 2 | 58,586 | 0 | 94,163 | |
| Splunk Inc | COM | 848637104 | 9,613 | 48,379 | SH | DFND | 3 | 48,379 | 0 | 0 | |
| Splunk Inc | COM | 848637104 | 14,681 | 73,884 | SH | SOLE | 0 | 73,884 | 0 | 0 | |
| Spotify Technology SA | SHS | L8681T102 | 322,835 | 1,250,378 | SH | DFND | 1 | 1,250,378 | 0 | 0 | |
| Spotify Technology SA | SHS | L8681T102 | 4,304,887 | 16,673,328 | SH | DFND | 2 | 11,543,717 | 0 | 5,129,611 | |
| Spotify Technology SA | SHS | L8681T102 | 118,414 | 458,630 | SH | DFND | 3 | 280,363 | 0 | 178,267 | |
| Spotify Technology SA | SHS | L8681T102 | 958,846 | 3,713,724 | SH | SOLE | 0 | 3,119,162 | 0 | 594,562 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 54,452 | 884,824 | SH | DFND | 1 | 884,824 | 0 | 0 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 36,807 | 598,091 | SH | DFND | 2 | 248,256 | 0 | 349,835 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 16,124 | 262,005 | SH | DFND | 3 | 233,362 | 0 | 28,643 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 25,886 | 420,644 | SH | SOLE | 0 | 420,644 | 0 | 0 | |
| Stericycle Inc | COM | 858912108 | 36,258 | 647,697 | SH | DFND | 1 | 647,697 | 0 | 0 | |
| Stericycle Inc | COM | 858912108 | 124,568 | 2,225,223 | SH | DFND | 2 | 2,056,775 | 0 | 168,448 | |
| Stericycle Inc | COM | 858912108 | 26,093 | 466,120 | SH | DFND | 3 | 214,670 | 0 | 251,450 | |
| Stericycle Inc | COM | 858912108 | 88,050 | 1,572,875 | SH | SOLE | 0 | 1,461,402 | 0 | 111,473 | |
| Stitch Fix | COM CL A | 860897107 | 54,244 | 2,174,966 | SH | DFND | 1 | 2,174,966 | 0 | 0 | |
| Stitch Fix | COM CL A | 860897107 | 51,764 | 2,075,538 | SH | DFND | 2 | 1,976,782 | 0 | 98,756 | |
| Stitch Fix | COM CL A | 860897107 | 761 | 30,502 | SH | DFND | 3 | 30,502 | 0 | 0 | |
| Stitch Fix | COM CL A | 860897107 | 15,348 | 615,378 | SH | SOLE | 0 | 615,378 | 0 | 0 | |
| StoneCo | COM CL A | G85158106 | 5,864 | 151,300 | SH | DFND | 2 | 151,300 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 3,589 | 226,300 | SH | DFND | 1 | 226,300 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 6,413 | 404,339 | SH | DFND | 2 | 157,289 | 0 | 247,050 | |
| Stratasys | SHS | M85548101 | 2,018 | 127,216 | SH | DFND | 3 | 127,216 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 2,293 | 144,600 | SH | SOLE | 0 | 144,600 | 0 | 0 | |
| Sunpower Corp | DBCV 4.000 1/1 | 867652AL3 | 5,243 | 6,311,000 | SH | DFND | 1 | 6,311,000 | 0 | 0 | |
| Sunpower Corp | DBCV 4.000 1/1 | 867652AL3 | 3 | 4,000 | SH | DFND | 2 | 4,000 | 0 | 0 | |
| Sunpower Corp | DBCV 4.000 1/1 | 867652AL3 | 716 | 862,000 | SH | DFND | 3 | 862,000 | 0 | 0 | |
| Sutro Biopharma | COM | 869367102 | 6,571 | 846,774 | SH | DFND | 1 | 846,774 | 0 | 0 | |
| Sutro Biopharma | COM | 869367102 | 5,069 | 653,226 | SH | SOLE | 0 | 653,226 | 0 | 0 | |
| T. Rowe Price | COM | 74144T108 | 10,137 | 82,078 | SH | DFND | 1 | 82,078 | 0 | 0 | |
| T. Rowe Price | COM | 74144T108 | 412 | 3,335 | SH | DFND | 2 | 0 | 0 | 3,335 | |
| T. Rowe Price | COM | 74144T108 | 13 | 105 | SH | DFND | 3 | 105 | 0 | 0 | |
| T. Rowe Price | COM | 74144T108 | 11,146 | 90,247 | SH | SOLE | 0 | 90,247 | 0 | 0 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 124,394 | 1,819,161 | SH | DFND | 1 | 1,819,161 | 0 | 0 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 2,669,855 | 39,044,380 | SH | DFND | 2 | 29,559,394 | 0 | 9,484,986 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 64,942 | 949,720 | SH | DFND | 3 | 619,109 | 0 | 330,611 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 259,262 | 3,791,491 | SH | SOLE | 0 | 1,959,288 | 0 | 1,832,203 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 32,060 | 881,258 | SH | DFND | 1 | 881,258 | 0 | 0 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 112,531 | 3,093,204 | SH | DFND | 2 | 2,849,828 | 0 | 243,376 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 23,811 | 654,501 | SH | DFND | 3 | 305,661 | 0 | 348,840 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 77,294 | 2,124,642 | SH | SOLE | 0 | 1,970,683 | 0 | 153,959 | |
| TJX Companies | COM | 872540109 | 1,829 | 36,176 | SH | DFND | 1 | 36,176 | 0 | 0 | |
| TJX Companies | COM | 872540109 | 7,889 | 156,027 | SH | DFND | 2 | 156,027 | 0 | 0 | |
| TJX Companies | COM | 872540109 | 1,080 | 21,357 | SH | DFND | 3 | 13,368 | 0 | 7,989 | |
| TJX Companies | COM | 872540109 | 832 | 16,449 | SH | SOLE | 0 | 16,449 | 0 | 0 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 126,279 | 2,224,389 | SH | DFND | 1 | 2,224,389 | 0 | 0 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 917,060 | 16,153,959 | SH | DFND | 2 | 11,838,306 | 0 | 4,315,653 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 72,775 | 1,281,927 | SH | DFND | 3 | 617,876 | 0 | 664,051 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 237,500 | 4,183,547 | SH | SOLE | 0 | 3,888,908 | 0 | 294,639 | |
| Tabula Rasa HealthCare Inc | COM | 873379101 | 8,608 | 157,275 | SH | DFND | 1 | 157,275 | 0 | 0 | |
| Tabula Rasa HealthCare Inc | COM | 873379101 | 8,434 | 154,101 | SH | DFND | 2 | 59,172 | 0 | 94,929 | |
| Tabula Rasa HealthCare Inc | COM | 873379101 | 2,681 | 48,993 | SH | DFND | 3 | 48,993 | 0 | 0 | |
| Tabula Rasa HealthCare Inc | COM | 873379101 | 5,303 | 96,894 | SH | SOLE | 0 | 96,894 | 0 | 0 | |
| Tandem Diabetes Care | COM NEW | 875372203 | 14,531 | 146,892 | SH | DFND | 1 | 146,892 | 0 | 0 | |
| Tandem Diabetes Care | COM NEW | 875372203 | 14,677 | 148,377 | SH | SOLE | 0 | 148,377 | 0 | 0 | |
| Teladoc | COM | 87918A105 | 278,766 | 1,460,733 | SH | DFND | 1 | 1,460,733 | 0 | 0 | |
| Teladoc | COM | 87918A105 | 488,272 | 2,558,542 | SH | DFND | 2 | 2,169,631 | 0 | 388,911 | |
| Teladoc | COM | 87918A105 | 102,791 | 538,625 | SH | DFND | 3 | 317,139 | 0 | 221,486 | |
| Teladoc | COM | 87918A105 | 268,804 | 1,408,531 | SH | SOLE | 0 | 1,329,253 | 0 | 79,278 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 6,494 | 482,432 | SH | DFND | 1 | 482,432 | 0 | 0 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 243,682 | 18,104,153 | SH | DFND | 2 | 12,415,050 | 0 | 5,689,103 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 26,235 | 1,949,121 | SH | SOLE | 0 | 1,949,121 | 0 | 0 | |
| Teradyne | COM | 880770102 | 75,376 | 891,919 | SH | DFND | 1 | 891,919 | 0 | 0 | |
| Teradyne | COM | 880770102 | 385,498 | 4,561,568 | SH | DFND | 2 | 4,329,487 | 0 | 232,081 | |
| Teradyne | COM | 880770102 | 53,707 | 635,509 | SH | DFND | 3 | 290,320 | 0 | 345,189 | |
| Teradyne | COM | 880770102 | 172,924 | 2,046,199 | SH | SOLE | 0 | 1,893,711 | 0 | 152,488 | |
| TerraForm Power | CL A COM | 88104R209 | 27,135 | 1,471,508 | SH | DFND | 1 | 1,471,508 | 0 | 0 | |
| TerraForm Power | CL A COM | 88104R209 | 80 | 4,350 | SH | DFND | 2 | 4,350 | 0 | 0 | |
| TerraForm Power | CL A COM | 88104R209 | 2,070 | 112,276 | SH | DFND | 3 | 112,276 | 0 | 0 | |
| Tesla Inc | COM | 88160R101 | 1,305,467 | 1,208,978 | SH | DFND | 1 | 1,208,978 | 0 | 0 | |
| Tesla Inc | COM | 88160R101 | 7,440,693 | 6,890,743 | SH | DFND | 2 | 4,803,438 | 0 | 2,087,305 | |
| Tesla Inc | COM | 88160R101 | 434,792 | 402,656 | SH | DFND | 3 | 248,662 | 0 | 153,994 | |
| Tesla Inc | COM | 88160R101 | 3,529,722 | 3,268,836 | SH | SOLE | 0 | 2,806,617 | 0 | 462,219 | |
| The Trade Desk | COM CL A | 88339J105 | 364,819 | 897,463 | SH | DFND | 1 | 897,463 | 0 | 0 | |
| The Trade Desk | COM CL A | 88339J105 | 495,762 | 1,219,587 | SH | DFND | 2 | 1,146,989 | 0 | 72,598 | |
| The Trade Desk | COM CL A | 88339J105 | 52,069 | 128,091 | SH | DFND | 3 | 67,148 | 0 | 60,943 | |
| The Trade Desk | COM CL A | 88339J105 | 229,253 | 563,967 | SH | SOLE | 0 | 538,269 | 0 | 25,698 | |
| Thermo Fisher Scientific | COM | 883556102 | 106,300 | 293,371 | SH | DFND | 1 | 293,371 | 0 | 0 | |
| Thermo Fisher Scientific | COM | 883556102 | 390,095 | 1,076,600 | SH | DFND | 2 | 1,001,066 | 0 | 75,534 | |
| Thermo Fisher Scientific | COM | 883556102 | 76,222 | 210,360 | SH | DFND | 3 | 97,916 | 0 | 112,444 | |
| Thermo Fisher Scientific | COM | 883556102 | 248,422 | 685,605 | SH | SOLE | 0 | 635,792 | 0 | 49,813 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 31,334 | 1,208,883 | SH | DFND | 1 | 1,208,883 | 0 | 0 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 401,919 | 15,506,134 | SH | DFND | 2 | 13,407,817 | 0 | 2,098,317 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 44,804 | 1,728,559 | SH | DFND | 3 | 400,148 | 0 | 1,328,411 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 1,242 | 47,913 | SH | DFND | 4 | 47,913 | 0 | 0 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 168,710 | 6,508,878 | SH | SOLE | 0 | 6,337,025 | 0 | 171,853 | |
| Trupanion | COM | 898202106 | 8,436 | 197,600 | SH | DFND | 1 | 197,600 | 0 | 0 | |
| Trupanion | COM | 898202106 | 16,266 | 381,021 | SH | DFND | 2 | 146,900 | 0 | 234,121 | |
| Trupanion | COM | 898202106 | 5,165 | 120,977 | SH | DFND | 3 | 120,977 | 0 | 0 | |
| Trupanion | COM | 898202106 | 31,377 | 735,000 | SH | SOLE | 0 | 735,000 | 0 | 0 | |
| Twilio Inc | CL A | 90138F102 | 109,262 | 497,959 | SH | DFND | 1 | 497,959 | 0 | 0 | |
| Twilio Inc | CL A | 90138F102 | 208,781 | 951,514 | SH | DFND | 2 | 872,974 | 0 | 78,540 | |
| Twilio Inc | CL A | 90138F102 | 29,324 | 133,644 | SH | DFND | 3 | 66,395 | 0 | 67,249 | |
| Twilio Inc | CL A | 90138F102 | 106,599 | 485,820 | SH | SOLE | 0 | 457,218 | 0 | 28,602 | |
| United Parcel Service | CL B | 911312106 | 25,356 | 228,060 | SH | DFND | 1 | 228,060 | 0 | 0 | |
| United Parcel Service | CL B | 911312106 | 1,211 | 10,893 | SH | DFND | 2 | 0 | 0 | 10,893 | |
| United Parcel Service | CL B | 911312106 | 33 | 299 | SH | DFND | 3 | 299 | 0 | 0 | |
| United Parcel Service | CL B | 911312106 | 27,151 | 244,210 | SH | SOLE | 0 | 244,210 | 0 | 0 | |
| Unity Biotechnology Inc | COM | 91381U101 | 2,153 | 248,000 | SH | DFND | 1 | 248,000 | 0 | 0 | |
| Unity Biotechnology Inc | COM | 91381U101 | 30,858 | 3,555,014 | SH | SOLE | 0 | 3,555,014 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 10,791 | 747,307 | SH | DFND | 1 | 747,307 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 10,658 | 738,107 | SH | DFND | 2 | 280,861 | 0 | 457,246 | |
| Upwork Inc | COM | 91688F104 | 3,372 | 233,548 | SH | DFND | 3 | 233,548 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 7,509 | 520,000 | SH | SOLE | 0 | 520,000 | 0 | 0 | |
| Uxin ADR | ADS | 91818X108 | 1,732 | 1,211,500 | SH | DFND | 1 | 1,211,500 | 0 | 0 | |
| Uxin ADR | ADS | 91818X108 | 807 | 564,600 | SH | SOLE | 0 | 564,600 | 0 | 0 | |
| Vale SA ADR | ADR | 91912E105 | 37,052 | 3,593,752 | SH | DFND | 1 | 3,593,752 | 0 | 0 | |
| Vale SA ADR | ADR | 91912E105 | 298,488 | 28,951,338 | SH | DFND | 2 | 12,426,529 | 0 | 16,524,809 | |
| Varian Medical Systems Inc | COM | 92220P105 | 7,965 | 65,009 | SH | DFND | 2 | 65,009 | 0 | 0 | |
| Veeco Instruments | COM | 922417100 | 7,917 | 586,854 | SH | DFND | 1 | 586,854 | 0 | 0 | |
| Veeco Instruments | COM | 922417100 | 7,563 | 560,637 | SH | DFND | 2 | 215,057 | 0 | 345,580 | |
| Veeco Instruments | COM | 922417100 | 2,367 | 175,453 | SH | DFND | 3 | 175,453 | 0 | 0 | |
| Verisk Analytics | COM | 92345Y106 | 11,265 | 66,186 | SH | DFND | 2 | 66,186 | 0 | 0 | |
| Vir Biotechnology Inc | COM | 92764N102 | 141,887 | 3,463,202 | SH | SOLE | 0 | 3,463,202 | 0 | 0 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 79,712 | 412,653 | SH | DFND | 1 | 412,653 | 0 | 0 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 288,746 | 1,494,777 | SH | DFND | 2 | 1,387,627 | 0 | 107,150 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 57,387 | 297,081 | SH | DFND | 3 | 138,387 | 0 | 158,694 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 186,272 | 964,292 | SH | SOLE | 0 | 892,970 | 0 | 71,322 | |
| Voya Prime Rate Trust | SH BEN INT | 92913A100 | 2,324 | 571,000 | SH | DFND | 1 | 571,000 | 0 | 0 | |
| Voya Prime Rate Trust | SH BEN INT | 92913A100 | 2,195 | 539,210 | SH | DFND | 3 | 539,210 | 0 | 0 | |
| Vroom Inc | COM | 92918V109 | 26,364 | 505,637 | SH | DFND | 1 | 505,637 | 0 | 0 | |
| Vroom Inc | COM | 92918V109 | 28,069 | 538,343 | SH | DFND | 2 | 512,125 | 0 | 26,218 | |
| Vroom Inc | COM | 92918V109 | 378 | 7,252 | SH | DFND | 3 | 7,252 | 0 | 0 | |
| Vroom Inc | COM | 92918V109 | 7,775 | 149,115 | SH | SOLE | 0 | 149,115 | 0 | 0 | |
| WEC Energy Group | COM | 92939U106 | 1,162 | 13,262 | SH | DFND | 1 | 13,262 | 0 | 0 | |
| Wabtec | COM | 929740108 | 27,589 | 479,223 | SH | DFND | 1 | 479,223 | 0 | 0 | |
| Wabtec | COM | 929740108 | 103,910 | 1,804,929 | SH | DFND | 2 | 1,676,489 | 0 | 128,440 | |
| Wabtec | COM | 929740108 | 20,653 | 358,754 | SH | DFND | 3 | 166,121 | 0 | 192,633 | |
| Wabtec | COM | 929740108 | 65,761 | 1,142,287 | SH | SOLE | 0 | 1,057,439 | 0 | 84,848 | |
| Waters | COM | 941848103 | 37,024 | 205,231 | SH | DFND | 1 | 205,231 | 0 | 0 | |
| Waters | COM | 941848103 | 125,936 | 698,094 | SH | DFND | 2 | 649,677 | 0 | 48,417 | |
| Waters | COM | 941848103 | 26,064 | 144,480 | SH | DFND | 3 | 68,751 | 0 | 75,729 | |
| Waters | COM | 941848103 | 79,476 | 440,556 | SH | SOLE | 0 | 408,879 | 0 | 31,677 | |
| Watsco Inc | COM | 942622200 | 120,841 | 680,030 | SH | DFND | 1 | 680,030 | 0 | 0 | |
| Watsco Inc | COM | 942622200 | 120,559 | 678,441 | SH | DFND | 2 | 648,038 | 0 | 30,403 | |
| Watsco Inc | COM | 942622200 | 5,075 | 28,557 | SH | DFND | 3 | 21,382 | 0 | 7,175 | |
| Watsco Inc | COM | 942622200 | 48,153 | 270,977 | SH | SOLE | 0 | 270,977 | 0 | 0 | |
| Wayfair Inc Class A | CL A | 94419L101 | 420,910 | 2,130,005 | SH | DFND | 1 | 2,130,005 | 0 | 0 | |
| Wayfair Inc Class A | CL A | 94419L101 | 418,765 | 2,119,151 | SH | DFND | 2 | 1,907,234 | 0 | 211,917 | |
| Wayfair Inc Class A | CL A | 94419L101 | 25,304 | 128,051 | SH | DFND | 3 | 114,970 | 0 | 13,081 | |
| Wayfair Inc Class A | CL A | 94419L101 | 338,633 | 1,713,642 | SH | SOLE | 0 | 1,713,642 | 0 | 0 | |
| Wheaton Precious Metals | COM | 962879102 | 360 | 8,165 | SH | DFND | 1 | 8,165 | 0 | 0 | |
| Wipro Ltd ADR | SPON ADR 1 SH | 97651M109 | 215 | 64,843 | SH | DFND | 2 | 64,843 | 0 | 0 | |
| Wix Com | SHS | M98068105 | 934,398 | 3,646,858 | SH | DFND | 2 | 1,948,032 | 0 | 1,698,826 | |
| Workday Inc | CL A | 98138H101 | 258,279 | 1,378,515 | SH | DFND | 1 | 1,378,515 | 0 | 0 | |
| Workday Inc | CL A | 98138H101 | 863,756 | 4,610,142 | SH | DFND | 2 | 2,265,658 | 0 | 2,344,484 | |
| Workday Inc | CL A | 98138H101 | 64,741 | 345,546 | SH | DFND | 3 | 229,071 | 0 | 116,475 | |
| Workday Inc | CL A | 98138H101 | 426,841 | 2,278,188 | SH | SOLE | 0 | 1,704,285 | 0 | 573,903 | |
| Xylem | COM | 98419M100 | 18,563 | 285,755 | SH | DFND | 1 | 285,755 | 0 | 0 | |
| Xylem | COM | 98419M100 | 6,531 | 100,540 | SH | DFND | 2 | 72,445 | 0 | 28,095 | |
| Xylem | COM | 98419M100 | 10,263 | 157,989 | SH | DFND | 3 | 61,029 | 0 | 96,960 | |
| Yext Inc | COM | 98585N106 | 71,879 | 4,327,479 | SH | DFND | 1 | 4,327,479 | 0 | 0 | |
| Yext Inc | COM | 98585N106 | 71,794 | 4,322,310 | SH | DFND | 2 | 3,248,219 | 0 | 1,074,091 | |
| Yext Inc | COM | 98585N106 | 10,094 | 607,692 | SH | DFND | 3 | 578,917 | 0 | 28,775 | |
| Yext Inc | COM | 98585N106 | 28,883 | 1,738,922 | SH | SOLE | 0 | 1,738,922 | 0 | 0 | |
| Zai Lab ADR | ADR | 98887Q104 | 72,566 | 883,547 | SH | DFND | 1 | 883,547 | 0 | 0 | |
| Zai Lab ADR | ADR | 98887Q104 | 143,538 | 1,747,690 | SH | DFND | 2 | 845,737 | 0 | 901,953 | |
| Zai Lab ADR | ADR | 98887Q104 | 26,647 | 324,445 | SH | DFND | 3 | 139,945 | 0 | 184,500 | |
| Zai Lab ADR | ADR | 98887Q104 | 29,140 | 354,800 | SH | SOLE | 0 | 354,800 | 0 | 0 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 59,594 | 1,036,786 | SH | DFND | 1 | 1,036,786 | 0 | 0 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 103,458 | 1,799,890 | SH | DFND | 2 | 1,636,612 | 0 | 163,278 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 5,483 | 95,385 | SH | DFND | 3 | 71,415 | 0 | 23,970 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 34,871 | 606,668 | SH | SOLE | 0 | 590,518 | 0 | 16,150 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 121,155 | 2,103,017 | SH | DFND | 1 | 2,103,017 | 0 | 0 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 282,083 | 4,896,424 | SH | DFND | 2 | 3,975,437 | 0 | 920,987 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 66,508 | 1,154,460 | SH | DFND | 3 | 671,681 | 0 | 482,779 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 189,503 | 3,289,420 | SH | SOLE | 0 | 3,078,105 | 0 | 211,315 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 297,681 | 1,174,097 | SH | DFND | 1 | 1,174,097 | 0 | 0 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 869,599 | 3,429,830 | SH | DFND | 2 | 1,710,828 | 0 | 1,719,002 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 64,537 | 254,543 | SH | DFND | 3 | 168,695 | 0 | 85,848 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 458,856 | 1,809,796 | SH | SOLE | 0 | 1,389,040 | 0 | 420,756 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 8,365 | 656,112 | SH | DFND | 1 | 656,112 | 0 | 0 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 5,178 | 406,143 | SH | DFND | 2 | 156,012 | 0 | 250,131 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 1,647 | 129,194 | SH | DFND | 3 | 129,194 | 0 | 0 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 3,128 | 245,311 | SH | SOLE | 0 | 245,311 | 0 | 0 | |
| iQIYI Inc ADR | SPON ADR | 46267X108 | 14,818 | 638,978 | SH | DFND | 1 | 638,978 | 0 | 0 | |
| iQIYI Inc ADR | SPON ADR | 46267X108 | 17 | 749 | SH | DFND | 3 | 749 | 0 | 0 | |
| iQIYI Inc ADR | SPON ADR | 46267X108 | 4,254 | 183,441 | SH | SOLE | 0 | 183,441 | 0 | 0 | |
| iRobot | COM | 462726100 | 9,034 | 107,680 | SH | DFND | 3 | 95,567 | 0 | 12,113 | |
| iRobot | COM | 462726100 | 20,343 | 242,470 | SH | DFND | 2 | 101,329 | 0 | 141,141 | |
| iRobot | COM | 462726100 | 14,637 | 174,459 | SH | DFND | 1 | 174,459 | 0 | 0 | |
| iRobot | COM | 462726100 | 26,833 | 319,820 | SH | SOLE | 0 | 319,820 | 0 | 0 | |