The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
TECHNIPFMC PLC COM G87110105 65,460 9,570,151 SH   SOLE   8,190,815 0 1,379,336
FULCRUM THERAPEUTICS INC COM 359616109 1,528 83,550 SH   SOLE   83,550 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,813 241,463 SH   SOLE   241,463 0 0
ALLY FINL INC COM 02005N100 151,285 7,629,105 SH   SOLE   6,881,997 0 747,108
OVID THERAPEUTICS INC COM 690469101 2,223 301,589 SH   SOLE   301,589 0 0
KONTOOR BRANDS INC COM 50050N103 6,015 337,755 SH   SOLE   337,755 0 0
CEDAR FAIR L P DEPOSITRY UNIT 150185106 5,007 182,063 SH   SOLE   182,063 0 0
ZYMEWORKS INC COM 98985W102 1,887 52,327 SH   SOLE   52,327 0 0
CENTOGENE N V COM N1976T109 1,352 59,080 SH   SOLE   59,080 0 0
GILEAD SCIENCES INC COM 375558103 126,338 1,642,032 SH   SOLE   1,441,577 0 200,455
MICROCHIP TECHNOLOGY INC. COM 595017104 251,394 2,387,179 SH   SOLE   2,130,508 0 256,671
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 315,400 8,591,653 SH   SOLE   7,572,042 0 1,019,611
AGIOS PHARMACEUTICALS INC COM 00847X104 3,677 68,752 SH   SOLE   68,752 0 0
BRF SA SPONSORED ADR 10552T107 5,512 1,388,303 SH   SOLE   1,159,226 0 229,077
ROKU INC COM CL A 77543R102 862 7,398 SH   SOLE   7,398 0 0
EQUIFAX INC COM 294429105 32,058 186,516 SH   SOLE   186,516 0 0
BOINGO WIRELESS INC COM 09739C102 1,186 89,043 SH   SOLE   89,043 0 0
PEABODY ENERGY CORP NEW COM 704551100 5,857 2,033,522 SH   SOLE   1,670,085 0 363,437
MICROSOFT CORP COM 594918104 5,087 24,998 SH   SOLE   24,998 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,712 70,793 SH   SOLE   70,793 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 36,952 1,450,817 SH   SOLE   1,450,817 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 832 920,294 SH   SOLE   920,294 0 0
GENETRON HLDGS LTD ADS 37186H100 2,683 222,314 SH   SOLE   222,314 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 196,383 1,535,920 SH   SOLE   1,388,716 0 147,204
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,997 327,414 SH   SOLE   327,414 0 0
CALLAWAY GOLF CO COM 131193104 3,581 204,516 SH   SOLE   204,516 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,760 83,737 SH   SOLE   83,737 0 0
BIO RAD LABS INC CL A 090572207 1,385 3,068 SH   SOLE   3,068 0 0
58 COM INC SPON ADR REP A 31680Q104 9,149 169,610 SH   SOLE   169,610 0 0
TRIP COM GROUP LTD ADS 89677Q107 204,517 7,890,309 SH   SOLE   7,204,501 0 685,808
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1,227 10,279 SH   SOLE   10,279 0 0
BIONTECH SE SPONSORED ADS 09075V102 24,546 367,788 SH   SOLE   367,788 0 0
ZAI LAB LTD ADR 98887Q104 5,613 68,337 SH   SOLE   68,337 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 424 15,000 SH   SOLE   15,000 0 0
CELLULAR BIOMEDICINE GROUP I COM NEW 15117P102 2,035 135,921 SH   SOLE   135,921 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 5,461 284,263 SH   SOLE   284,263 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 2,944 100,314 SH   SOLE   100,314 0 0
ALKERMES PLC SHS G01767105 3,158 162,716 SH   SOLE   162,716 0 0
ACCELERON PHARMA INC COM 00434H108 1,886 19,800 SH   SOLE   19,800 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,142 357,020 SH   SOLE   357,020 0 0
LAM RESEARCH CORP COM 512807108 89,255 275,938 SH   SOLE   236,375 0 39,563
QIWI PLC SPON ADR REP B 74735M108 6,928 400,000 SH   SOLE   400,000 0 0
BARRICK GOLD CORPORATION COM 067901108 89,052 3,305,563 SH   SOLE   2,899,933 0 405,630
LOUISIANA PAC CORP COM 546347105 6,840 266,673 SH   SOLE   266,673 0 0
ALPHABET INC CAP STK CL C 02079K107 199,671 141,249 SH   SOLE   135,098 0 6,151
COHERUS BIOSCIENCES INC COM 19249H103 2,537 142,034 SH   SOLE   142,034 0 0
KOHLS CORP COM 500255104 6,359 306,161 SH   SOLE   306,161 0 0
CANADA GOOSE HLDGS INC SHS SUB VTG 135086106 6,890 297,380 SH   SOLE   297,380 0 0
ARYA SCIENCES ACQUISITION CO SHS CL A G3165V109 2,663 169,171 SH   SOLE   169,171 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 61,273 2,757,549 SH   SOLE   2,478,056 0 279,493
SINA CORP ORD G81477104 253 7,057 SH   SOLE   7,057 0 0
FACEBOOK INC CL A 30303M102 262,455 1,155,833 SH   SOLE   1,034,993 0 120,840
SANGAMO THERAPEUTICS INC COM 800677106 2,155 240,512 SH   SOLE   240,512 0 0
BITAUTO HLDGS LTD SPONSORED ADS 091727107 0 9 SH   SOLE   9 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 34,650 3,178,857 SH   SOLE   2,682,683 0 496,174
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,203 462,402 SH   SOLE   462,402 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,614 154,954 SH   SOLE   154,954 0 0
MODERNA INC COM 60770K107 1,994 31,060 SH   SOLE   31,060 0 0
PERKINELMER INC COM 714046109 2,289 23,334 SH   SOLE   23,334 0 0
XILINX INC COM 983919101 906 9,209 SH   SOLE   9,209 0 0
MERUS N V COM N5749R100 3,064 190,408 SH   SOLE   190,408 0 0
ALPHABET INC CAP STK CL A 02079K305 67,187 47,380 SH   SOLE   33,573 0 13,807
MOMO INC ADR 60879B107 78,842 4,510,384 SH   SOLE   4,343,240 0 167,144
FEDEX CORP COM 31428X106 44,355 316,321 SH   SOLE   270,144 0 46,177
MELCO RESORTS AND ENTMNT LTD ADR 585464100 68,135 4,390,171 SH   SOLE   4,390,171 0 0
VAIL RESORTS INC COM 91879Q109 43,117 236,712 SH   SOLE   203,012 0 33,700
LIVANOVA PLC SHS G5509L101 3,446 71,603 SH   SOLE   71,603 0 0
SEAWORLD ENTMT INC COM 81282V100 3,776 254,975 SH   SOLE   254,975 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 253 17,000 SH   SOLE   17,000 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 1,332 17,640 SH   SOLE   17,640 0 0
QUANTERIX CORP COM 74766Q101 5,447 198,864 SH   SOLE   198,864 0 0
INTEL CORP COM 458140100 176,705 2,953,451 SH   SOLE   2,638,109 0 315,342
ANALOG DEVICES INC COM 032654105 1,315 10,720 SH   SOLE   10,720 0 0
CARDINAL HEALTH INC COM 14149Y108 2,331 44,670 SH   SOLE   44,670 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 43,688 851,453 SH   SOLE   749,234 0 102,219
PIERIS PHARMACEUTICALS INC COM 720795103 1,577 508,768 SH   SOLE   508,768 0 0
ARYA SCIENCES ACQUISTION CO UNIT 06/09/2027 G31655114 58 5,000 SH   SOLE   5,000 0 0
TWILIO INC CL A 90138F102 699 3,184 SH   SOLE   3,184 0 0
SIGNET JEWELERS LIMITED SHS G81276100 4,853 472,575 SH   SOLE   472,575 0 0
LIVERAMP HLDGS INC COM 53815P108 142 3,347 SH   SOLE   3,347 0 0
APPLE INC COM 037833100 1,956 5,362 SH   SOLE   5,362 0 0
BAIDU INC SPON ADR REP A 056752108 29,120 242,887 SH   SOLE   242,887 0 0
IHS MARKIT LTD SHS G47567105 17,685 234,239 SH   SOLE   234,239 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 111,908 3,192,821 SH   SOLE   3,192,821 0 0
WARRIOR MET COAL INC COM 93627C101 12,468 810,120 SH   SOLE   676,820 0 133,300
GOLDEN OCEAN GROUP LTD SHS NEW G39637205 5,799 1,500,000 SH   SOLE   1,500,000 0 0
ISHARES TR MSCI INDIA ETF 46429B598 768 26,449 SH   SOLE   26,449 0 0
MEDALLIA INC COM 584021109 51,006 2,020,857 SH   SOLE   1,739,984 0 280,873
MERSANA THERAPEUTICS INC COM 59045L106 2,595 110,906 SH   SOLE   110,906 0 0
BLUEBIRD BIO INC COM 09609G100 30,995 507,784 SH   SOLE   443,094 0 64,690
ULTA BEAUTY INC COM 90384S303 8,956 44,028 SH   SOLE   44,028 0 0
JD.COM INC SPON ADR CL A 47215P106 84,014 1,396,053 SH   SOLE   1,396,053 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,314 126,185 SH   SOLE   126,185 0 0
TIFFANY & CO NEW COM 886547108 20,254 166,097 SH   SOLE   166,097 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 831 415,450 SH   SOLE   415,450 0 0
CENTURYLINK INC COM 156700106 611 60,907 SH   SOLE   60,907 0 0
CARVANA CO CL A 146869102 15,247 126,846 SH   SOLE   126,846 0 0
BOOKING HOLDINGS INC COM 09857L108 276,496 173,641 SH   SOLE   155,132 0 18,509
ARCUS BIOSCIENCES INC COM 03969F109 2,154 87,058 SH   SOLE   87,058 0 0
WABTEC COM 929740108 15,009 260,714 SH   SOLE   255,900 0 4,814
WYNDHAM HOTELS & RESORTS INC COM 98311A105 3,257 76,409 SH   SOLE   76,409 0 0
FREEPORT-MCMORAN INC CL B 35671D857 16,563 1,431,587 SH   SOLE   1,177,206 0 254,381
ALECTOR INC COM 014442107 1,375 56,240 SH   SOLE   56,240 0 0
PROTHENA CORP PLC SHS G72800108 1,341 128,223 SH   SOLE   128,223 0 0
APPIAN CORP CL A 03782L101 548 10,693 SH   SOLE   10,693 0 0
FOOT LOCKER INC COM 344849104 4,445 152,434 SH   SOLE   152,434 0 0
MICRON TECHNOLOGY INC COM 595112103 235,452 4,570,104 SH   SOLE   4,063,992 0 506,112
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,365 48,890 SH   SOLE   48,890 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 271,899 1,260,543 SH   SOLE   1,150,259 0 110,284
NUVASIVE INC COM 670704105 1,041 18,705 SH   SOLE   18,705 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 2,955 856,526 SH   SOLE   856,526 0 0
YUM CHINA HLDGS INC COM 98850P109 62,587 1,301,994 SH   SOLE   1,301,994 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 324 14,800 SH   SOLE   14,800 0 0
KINGSOFT CLOUD HLDGS LTD ADS 49639K101 423 13,431 SH   SOLE   13,431 0 0
NORBORD INC COM NEW 65548P403 308 13,504 SH   SOLE   13,504 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 3,034 110,009 SH   SOLE   110,009 0 0
CISCO SYS INC COM 17275R102 1,665 35,700 SH   SOLE   35,700 0 0
GENERAL ELECTRIC CO COM 369604103 236,867 34,680,403 SH   SOLE   30,144,406 0 4,535,997
MYOVANT SCIENCES LTD COM G637AM102 6,294 305,230 SH   SOLE   305,230 0 0
ORACLE CORP COM 68389X105 1,626 29,418 SH   SOLE   29,418 0 0
PAYPAL HLDGS INC COM 70450Y103 2,767 15,884 SH   SOLE   15,884 0 0
EBAY INC. COM 278642103 1,271 24,235 SH   SOLE   24,235 0 0
JOHNSON & JOHNSON COM 478160104 3,585 25,495 SH   SOLE   25,495 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 3,082 39,511 SH   SOLE   39,511 0 0