The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 29,250 327,512 SH   DFND 1 326,699 0 813
ABBOTT LABS COM 002824100 65,893 720,696 SH   DFND 1 720,696 0 0
ABBVIE INC COM 00287Y109 43,382 441,865 SH   DFND 1 441,865 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 23,084 918,926 SH   DFND 1 918,926 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 4,066 161,878 SH   OTR 2 161,878 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 7,359 151,823 SH   DFND 1 151,823 0 0
ADECOAGRO S A COM L00849106 11,741 2,705,281 SH   DFND 1 2,705,281 0 0
ADECOAGRO S A COM L00849106 2,034 468,717 SH   OTR 2 468,717 0 0
ADOBE INC COM 00724F101 2,995,433 6,881,149 SH   DFND 1 6,591,375 0 289,774
ADOBE INC COM 00724F101 49,215 113,057 SH   OTR 2 113,057 0 0
ADTALEM GLOBAL ED INC COM 00737L103 762 24,450 SH   DFND 1 24,450 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 35,676 250,446 SH   DFND 1 250,446 0 0
ADVANCED MICRO DEVICES INC COM 007903107 53,129 1,009,871 SH   DFND 1 1,005,817 0 4,054
AES CORP COM 00130H105 42,730 2,948,944 SH   DFND 1 2,948,944 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 35,638 403,283 SH   DFND 1 401,527 0 1,756
AGIOS PHARMACEUTICALS INC COM 00847X104 16,188 302,681 SH   DFND 1 302,681 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,697 50,436 SH   OTR 2 50,436 0 0
AGNICO EAGLE MINES LTD COM 008474108 32,443 506,448 SH   DFND 1 506,359 0 89
AIR PRODS & CHEMS INC COM 009158106 7,560 31,309 SH   DFND 1 31,303 0 6
AIR TRANSPORT SERVICES GRP I COM 00922R105 563 25,284 SH   DFND 1 25,284 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 502 36,934 SH   DFND 1 36,934 0 0
ALCON AG ORD SHS H01301128 375,501 6,547,672 SH   DFND 1 6,295,197 0 252,475
ALCON AG ORD SHS H01301128 14,176 247,063 SH   OTR 2 247,063 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 16,608 102,362 SH   DFND 1 102,362 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,724 33,182 SH   DFND 1 33,182 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2,010,275 9,319,770 SH   DFND 1 8,995,667 0 324,103
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 39,487 183,065 SH   OTR 2 183,065 0 0
ALIGN TECHNOLOGY INC COM 016255101 32,352 117,882 SH   DFND 1 117,366 0 516
ALLEGHANY CORP DEL COM 017175100 8,845 18,083 SH   DFND 1 18,083 0 0
ALLIANT ENERGY CORP COM 018802108 100,975 2,110,672 SH   DFND 1 2,110,672 0 0
ALPHABET INC CAP STK CL A 02079K305 2,219,994 1,565,526 SH   DFND 1 1,508,919 0 56,607
ALPHABET INC CAP STK CL A 02079K305 21,943 15,474 SH   OTR 2 15,474 0 0
ALPHABET INC CAP STK CL C 02079K107 2,165,871 1,532,156 SH   DFND 1 1,458,660 0 73,496
ALPHABET INC CAP STK CL C 02079K107 21,826 15,440 SH   OTR 2 15,440 0 0
ALTRIA GROUP INC COM 02209S103 1,071 27,280 SH   DFND 1 27,280 0 0
AMAZON COM INC COM 023135106 7,322,408 2,654,181 SH   DFND 1 2,541,924 0 112,257
AMAZON COM INC COM 023135106 145,845 52,865 SH   OTR 2 52,865 0 0
AMER STATES WTR CO COM 029899101 472 6,008 SH   DFND 1 6,008 0 0
AMEREN CORP COM 023608102 165,897 2,357,837 SH   DFND 1 2,357,837 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 47,860 1,368,996 SH   DFND 1 1,368,996 0 0
AMERICAN ELEC PWR CO INC COM 025537101 227,930 2,862,007 SH   DFND 1 2,862,007 0 0
AMERICAN ELEC PWR CO INC UNIT 03/15/2022 025537127 7,514 155,220 SH   DFND 1 155,220 0 0
AMERICAN EQTY INVT LIFE HLD COM 025676206 535 21,635 SH   DFND 1 21,635 0 0
AMERICAN EXPRESS CO COM 025816109 2,917 30,641 SH   DFND 1 30,641 0 0
AMERICAN TOWER CORP NEW COM 03027X100 745,361 2,882,961 SH   DFND 1 2,717,885 0 165,076
AMERICAN TOWER CORP NEW COM 03027X100 6,167 23,853 SH   OTR 2 23,853 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 69,792 542,451 SH   DFND 1 542,451 0 0
AMERIS BANCORP COM 03076K108 27,637 1,171,555 SH   DFND 1 1,171,555 0 0
AMERIS BANCORP COM 03076K108 5,021 212,839 SH   OTR 2 212,839 0 0
AMERISOURCEBERGEN CORP COM 03073E105 3,032 30,093 SH   DFND 1 30,093 0 0
AMETEK INC COM 031100100 34,938 390,941 SH   DFND 1 389,232 0 1,709
AMGEN INC COM 031162100 1,332 5,646 SH   DFND 1 5,646 0 0
AMICUS THERAPEUTICS INC COM 03152W109 70,370 4,666,495 SH   DFND 1 4,666,495 0 0
AMICUS THERAPEUTICS INC COM 03152W109 6,309 418,344 SH   OTR 2 418,344 0 0
AMKOR TECHNOLOGY INC COM 031652100 1,672 135,849 SH   DFND 1 135,849 0 0
AMN HEALTHCARE SVCS INC COM 001744101 673 14,867 SH   DFND 1 14,867 0 0
AMPHENOL CORP NEW CL A 032095101 29,636 309,320 SH   DFND 1 308,003 0 1,317
ANTHEM INC COM 036752103 25,676 97,633 SH   DFND 1 97,633 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 66,574 2,038,416 SH   DFND 1 2,038,416 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,896 88,662 SH   OTR 2 88,662 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 15,880 318,102 SH   DFND 1 316,729 0 1,373
APPFOLIO INC COM CL A 03783C100 20,652 126,925 SH   DFND 1 126,925 0 0
APPFOLIO INC COM CL A 03783C100 3,808 23,403 SH   OTR 2 23,403 0 0
APPLE INC COM 037833100 5,709,200 15,650,219 SH   DFND 1 15,047,142 0 603,077
APPLE INC COM 037833100 110,285 302,316 SH   OTR 2 302,316 0 0
APTIV PLC SHS G6095L109 28,640 367,552 SH   DFND 1 365,996 0 1,556
ARAMARK COM 03852U106 2,300 101,912 SH   DFND 1 101,912 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 618 339,639 SH   DFND 1 339,639 0 0
ARCO PLATFORM LTD COM CL A G04553106 1,369 31,490 SH   DFND 1 31,490 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 7,545 161,424 SH   DFND 1 161,424 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 29,725 748,737 SH   DFND 1 746,515 0 2,222
ARGENX SE SPONSORED ADR 04016X101 102,131 453,450 SH   DFND 1 452,998 0 452
ARMSTRONG WORLD INDS INC COM 04247X102 7,223 92,653 SH   DFND 1 92,653 0 0
ARMSTRONG WORLD INDS INC COM 04247X102 1,337 17,146 SH   OTR 2 17,146 0 0
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 1,758 54,091 SH   DFND 1 54,091 0 0
ARYA SCIENCES ACQUISITION CO *W EXP 10/10/202 G3165V125 2,085 386,035 SH   DFND 1 386,035 0 0
ASBURY AUTOMOTIVE GROUP INC COM 043436104 737 9,529 SH   DFND 1 9,529 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 11,391 30,950 SH   DFND 1 30,594 0 356
ASSEMBLY BIOSCIENCES INC COM 045396108 54,878 2,353,274 SH   DFND 1 2,353,274 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 15,084 552,739 SH   DFND 1 552,739 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 2,632 96,444 SH   OTR 2 96,444 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 2,050,512 38,769,383 SH   DFND 1 37,859,882 0 909,501
ASTRAZENECA PLC SPONSORED ADR 046353108 19,271 364,353 SH   OTR 2 364,353 0 0
AT&T INC COM 00206R102 34,292 1,134,356 SH   DFND 1 1,134,356 0 0
ATKORE INTL GROUP INC COM 047649108 1,662 60,760 SH   DFND 1 60,760 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 5,069 218,872 SH   DFND 1 218,872 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 1,330 57,418 SH   OTR 2 57,418 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 5,399 185,545 SH   DFND 1 185,545 0 0
ATLASSIAN CORP PLC CL A G06242104 1,001,778 5,557,094 SH   DFND 1 5,423,513 0 133,581
ATLASSIAN CORP PLC CL A G06242104 22,070 122,429 SH   OTR 2 122,429 0 0
ATMOS ENERGY CORP COM 049560105 49,119 493,257 SH   DFND 1 493,257 0 0
AUTOZONE INC COM 053332102 3,786 3,356 SH   DFND 1 3,356 0 0
AVALARA INC COM 05338G106 68,180 512,288 SH   DFND 1 510,915 0 1,373
AVANGRID INC COM 05351W103 29,861 711,308 SH   DFND 1 711,308 0 0
AVANTOR INC COM 05352A100 18,077 1,063,377 SH   DFND 1 1,063,377 0 0
AVERY DENNISON CORP COM 053611109 1,415 12,406 SH   DFND 1 12,406 0 0
AVISTA CORP COM 05379B107 399 10,971 SH   DFND 1 10,971 0 0
AXIS CAPITAL HOLDINGS LTD SHS G0692U109 23,221 572,523 SH   DFND 1 572,523 0 0
AXIS CAPITAL HOLDINGS LTD SHS G0692U109 3,206 79,041 SH   OTR 2 79,041 0 0
AXOS FINANCIAL INC COM 05465C100 660 29,897 SH   DFND 1 29,897 0 0
B2GOLD CORP COM 11777Q209 4,135 726,901 SH   DFND 1 726,644 0 257
BAKER HUGHES COMPANY CL A 05722G100 4,961 322,323 SH   DFND 1 322,200 0 123
BANCORPSOUTH BK TUPELO MISS COM 05971J102 581 25,571 SH   DFND 1 25,571 0 0
BANDWIDTH INC COM CL A 05988J103 54,511 429,225 SH   DFND 1 429,225 0 0
BANDWIDTH INC COM CL A 05988J103 15,371 121,029 SH   OTR 2 121,029 0 0
BANKUNITED INC COM 06652K103 40,414 1,995,747 SH   DFND 1 1,995,747 0 0
BANKUNITED INC COM 06652K103 5,718 282,364 SH   OTR 2 282,364 0 0
BARRICK GOLD CORPORATION COM 067901108 21,617 802,410 SH   DFND 1 802,113 0 297
BEIGENE LTD SPONSORED ADR 07725L102 915 4,858 SH   DFND 1 4,858 0 0
BERRY GLOBAL GROUP INC COM 08579W103 1,326 29,910 SH   DFND 1 29,910 0 0
BHP GROUP LTD SPONSORED ADS 088606108 16,985 341,537 SH   DFND 1 341,410 0 127
BIG LOTS INC COM 089302103 911 21,691 SH   DFND 1 21,691 0 0
BILIBILI INC SPONS ADS REP Z 090040106 2,586 55,829 SH   DFND 1 55,829 0 0
BIO RAD LABS INC CL A 090572207 2,819 6,244 SH   DFND 1 6,225 0 19
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 682 9,328 SH   DFND 1 9,328 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 929,046 7,532,394 SH   DFND 1 7,276,571 0 255,823
BIOMARIN PHARMACEUTICAL INC COM 09061G101 7,199 58,371 SH   OTR 2 58,371 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 32,956 884,248 SH   DFND 1 884,248 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 5,474 146,865 SH   OTR 2 146,865 0 0
BK OF AMERICA CORP COM 060505104 111,884 4,710,901 SH   DFND 1 4,710,901 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 18,078 428,806 SH   DFND 1 428,806 0 0
BLACK HILLS CORP COM 092113109 581 10,248 SH   DFND 1 10,248 0 0
BLACKLINE INC COM 09239B109 9,500 114,585 SH   DFND 1 114,585 0 0
BLACKLINE INC COM 09239B109 3,461 41,742 SH   OTR 2 41,742 0 0
BLACKSTONE MTG TR INC COM CL A 09257W100 853 35,400 SH   DFND 1 35,400 0 0
BMC STK HLDGS INC COM 05591B109 745 29,653 SH   DFND 1 29,653 0 0
BOEING CO COM 097023105 539,948 2,945,707 SH   DFND 1 2,775,551 0 170,156
BOEING CO COM 097023105 8,534 46,559 SH   OTR 2 46,559 0 0
BOISE CASCADE CO DEL COM 09739D100 698 18,570 SH   DFND 1 18,570 0 0
BOOT BARN HLDGS INC COM 099406100 11,198 519,372 SH   DFND 1 519,372 0 0
BOOT BARN HLDGS INC COM 099406100 2,153 99,867 SH   OTR 2 99,867 0 0
BOOZ ALLEN HAMILTON HLDG COR CL A 099502106 1,343 17,266 SH   DFND 1 17,266 0 0
BOSTON BEER INC CL A 100557107 1,280 2,386 SH   DFND 1 2,386 0 0
BOSTON SCIENTIFIC CORP 5.50% CNV PFD A 101137206 1,152 11,000 SH   DFND 1 11,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 315,367 8,982,250 SH   DFND 1 8,466,971 0 515,279
BP PLC SPONSORED ADR 055622104 5,766 247,242 SH   DFND 1 247,169 0 73
BRIGHT HORIZONS FAM SOL IN D COM 109194100 31,226 266,433 SH   DFND 1 265,278 0 1,155
BRIGHTHOUSE FINL INC COM 10922N103 11,972 430,340 SH   DFND 1 430,340 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 41,087 3,297,476 SH   DFND 1 3,297,476 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 6,117 490,959 SH   OTR 2 490,959 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 99,793 1,697,164 SH   DFND 1 1,697,164 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 2,987 834,349 SH   DFND 1 834,349 0 0
BROADCOM INC COM 11135F101 81,580 258,482 SH   DFND 1 258,482 0 0
BROOKDALE SR LIVING INC COM 112463104 726 246,123 SH   DFND 1 246,123 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 8,054 168,132 SH   DFND 1 168,132 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 5,831 578,553 SH   DFND 1 578,553 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 2,075 205,809 SH   OTR 2 205,809 0 0
BROOKS AUTOMATION INC NEW COM 114340102 38,480 869,817 SH   DFND 1 869,817 0 0
BROOKS AUTOMATION INC NEW COM 114340102 5,920 133,806 SH   OTR 2 133,806 0 0
BRUNSWICK CORP COM 117043109 17,441 272,483 SH   DFND 1 272,483 0 0
BRUNSWICK CORP COM 117043109 2,989 46,692 SH   OTR 2 46,692 0 0
BUCKLE INC COM 118440106 766 48,879 SH   DFND 1 48,879 0 0
BUILDERS FIRSTSOURCE INC COM 12008R107 1,769 85,443 SH   DFND 1 85,443 0 0
BURLINGTON STORES INC COM 122017106 73,896 375,242 SH   DFND 1 374,119 0 1,123
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 12,750 472,046 SH   DFND 1 472,046 0 0
BYLINE BANCORP INC COM 124411109 8,997 686,841 SH   DFND 1 686,841 0 0
BYLINE BANCORP INC COM 124411109 2,937 224,180 SH   OTR 2 224,180 0 0
CABOT OIL & GAS CORP COM 127097103 1,727 100,539 SH   DFND 1 100,500 0 39
CACTUS INC CL A 127203107 1,293 62,659 SH   DFND 1 62,659 0 0
CAMPING WORLD HLDGS INC CL A 13462K109 894 32,930 SH   DFND 1 32,930 0 0
CAPITAL ONE FINL CORP COM 14040H105 54,465 870,190 SH   DFND 1 870,190 0 0
CARDLYTICS INC COM 14161W105 26,372 376,851 SH   DFND 1 376,851 0 0
CARDLYTICS INC COM 14161W105 4,337 61,969 SH   OTR 2 61,969 0 0
CARVANA CO CL A 146869102 184,659 1,536,261 SH   DFND 1 1,501,394 0 34,867
CARVANA CO CL A 146869102 3,671 30,542 SH   OTR 2 30,542 0 0
CATALENT INC COM 148806102 68,699 937,236 SH   DFND 1 934,688 0 2,548
CBIZ INC COM 124805102 900 37,559 SH   DFND 1 37,559 0 0
CBRE GROUP INC CL A 12504L109 27,120 599,741 SH   DFND 1 597,237 0 2,504
CDW CORP COM 12514G108 44,814 385,725 SH   DFND 1 384,788 0 937
CENTENE CORP DEL COM 15135B101 63,770 1,003,459 SH   DFND 1 1,001,718 0 1,741
CENTERPOINT ENERGY INC COM 15189T107 62,909 3,369,498 SH   DFND 1 3,369,498 0 0
CHANGE HEALTHCARE INC COM 15912K100 5,815 519,171 SH   DFND 1 519,171 0 0
CHART INDS INC COM PAR $0.01 16115Q308 6,762 139,449 SH   DFND 1 139,401 0 48
CHARTER COMMUNICATIONS INC N CL A 16119P108 6,533 12,808 SH   DFND 1 12,808 0 0
CHENIERE ENERGY INC COM NEW 16411R208 97,278 2,013,204 SH   DFND 1 2,013,123 0 81
CHENIERE ENERGY PARTNERS LP COM UNIT 16411Q101 9,535 272,578 SH   DFND 1 272,578 0 0
CHEVRON CORP NEW COM 166764100 149,934 1,680,305 SH   DFND 1 1,680,254 0 51
CHEWY INC CL A 16679L109 24,478 547,726 SH   DFND 1 546,162 0 1,564
CHIPOTLE MEXICAN GRILL INC COM 169656105 964,909 916,900 SH   DFND 1 877,828 0 39,072
CHIPOTLE MEXICAN GRILL INC COM 169656105 13,373 12,708 SH   OTR 2 12,708 0 0
CHUBB LIMITED COM H1467J104 128,201 1,012,485 SH   DFND 1 1,012,485 0 0
CHURCH & DWIGHT INC COM 171340102 46,155 597,088 SH   DFND 1 594,825 0 2,263
CIGNA CORP NEW COM 125523100 120,928 644,434 SH   DFND 1 644,434 0 0
CINTAS CORP COM 172908105 2,286 8,583 SH   DFND 1 8,583 0 0
CISCO SYS INC COM 17275R102 25,950 556,380 SH   DFND 1 556,380 0 0
CITIGROUP INC COM NEW 172967424 100,012 1,957,191 SH   DFND 1 1,957,191 0 0
CITRIX SYS INC COM 177376100 3,035 20,521 SH   DFND 1 20,521 0 0
CLEARWAY ENERGY INC CL C 18539C204 8,404 364,436 SH   DFND 1 364,436 0 0
CMS ENERGY CORP COM 125896100 139,983 2,396,156 SH   DFND 1 2,396,156 0 0
CNO FINL GROUP INC COM 12621E103 1,764 113,270 SH   DFND 1 113,270 0 0
COCA COLA CO COM 191216100 2,180 48,800 SH   DFND 1 48,800 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 468 6,049 SH   DFND 1 6,049 0 0
COGNEX CORP COM 192422103 28,258 473,168 SH   DFND 1 471,117 0 2,051
COHEN & STEERS INC COM 19247A100 702 10,311 SH   DFND 1 10,311 0 0
COLUMBIA PPTY TR INC COM NEW 198287203 10,540 802,125 SH   DFND 1 802,125 0 0
COLUMBIA PPTY TR INC COM NEW 198287203 1,808 137,622 SH   OTR 2 137,622 0 0
COMCAST CORP NEW CL A 20030N101 24,857 637,679 SH   DFND 1 637,679 0 0
CONCHO RES INC COM 20605P101 10,134 196,769 SH   DFND 1 196,695 0 74
CONOCOPHILLIPS COM 20825C104 86,165 2,050,564 SH   DFND 1 2,050,453 0 111
CONSTELLATION BRANDS INC CL A 21036P108 101,734 581,506 SH   DFND 1 393,262 0 188,244
CONSTELLATION PHARMCETICLS I COM 210373106 18,336 610,185 SH   DFND 1 610,185 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 1,614 53,722 SH   OTR 2 53,722 0 0
CONSTELLIUM SE CL A SHS F21107101 6,216 809,324 SH   DFND 1 809,019 0 305
CONSTRUCTION PARTNERS INC COM CL A 21044C107 7,782 438,160 SH   DFND 1 438,160 0 0
CONSTRUCTION PARTNERS INC COM CL A 21044C107 1,927 108,508 SH   OTR 2 108,508 0 0
COOPER COS INC COM NEW 216648402 23,198 81,786 SH   DFND 1 81,424 0 362
CORECIVIC INC COM 21871N101 479 51,197 SH   DFND 1 51,197 0 0
COSTAR GROUP INC COM 22160N109 61,703 86,823 SH   DFND 1 86,453 0 370
COSTCO WHSL CORP NEW COM 22160K105 1,157,461 3,817,358 SH   DFND 1 3,619,175 0 198,183
COSTCO WHSL CORP NEW COM 22160K105 14,237 46,953 SH   OTR 2 46,953 0 0
COUPA SOFTWARE INC COM 22266L106 1,327,265 4,790,880 SH   DFND 1 4,624,299 0 166,581
COUPA SOFTWARE INC COM 22266L106 18,759 67,711 SH   OTR 2 67,711 0 0
COUSINS PPTYS INC COM NEW 222795502 39,415 1,321,309 SH   DFND 1 1,321,309 0 0
COUSINS PPTYS INC COM NEW 222795502 5,631 188,778 SH   OTR 2 188,778 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 20,518 279,188 SH   DFND 1 279,188 0 0
CROCS INC COM 227046109 681 18,497 SH   DFND 1 18,497 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 852,442 8,499,776 SH   DFND 1 8,301,912 0 197,864
CROWDSTRIKE HLDGS INC CL A 22788C105 19,628 195,709 SH   OTR 2 195,709 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 31,836 190,235 SH   DFND 1 190,235 0 0
CROWN HLDGS INC COM 228368106 53,378 819,567 SH   DFND 1 818,232 0 1,335
CUE BIOPHARMA INC COM 22978P106 733 29,924 SH   DFND 1 29,924 0 0
CURTISS WRIGHT CORP COM 231561101 11,014 123,368 SH   DFND 1 123,368 0 0
CURTISS WRIGHT CORP COM 231561101 1,602 17,940 SH   OTR 2 17,940 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 50,272 506,415 SH   DFND 1 505,881 0 534
CYBERARK SOFTWARE LTD SHS M2682V108 6,450 64,975 SH   OTR 2 64,975 0 0
CYTOKINETICS INC COM NEW 23282W605 14,547 617,183 SH   DFND 1 617,183 0 0
D R HORTON INC COM 23331A109 73,915 1,333,000 SH   DFND 1 1,333,000 0 0
DANAHER CORPORATION 4.75 MND CV PFD 235851300 1,586 1,272 SH   DFND 1 1,272 0 0
DANAHER CORPORATION COM 235851102 711,023 4,020,937 SH   DFND 1 3,808,373 0 212,564
DANAHER CORPORATION COM 235851102 5,367 30,353 SH   OTR 2 30,353 0 0
DARLING INGREDIENTS INC COM 237266101 60,607 2,461,676 SH   DFND 1 2,461,577 0 99
DARLING INGREDIENTS INC COM 237266101 8,691 353,019 SH   OTR 2 353,019 0 0
DEERE & CO COM 244199105 11,673 74,280 SH   DFND 1 74,280 0 0
DELL TECHNOLOGIES INC CL C 24703L202 2,860 52,061 SH   DFND 1 52,061 0 0
DENALI THERAPEUTICS INC COM 24823R105 10,655 440,641 SH   DFND 1 440,641 0 0
DEXCOM INC COM 252131107 1,091,354 2,692,042 SH   DFND 1 2,552,720 0 139,322
DEXCOM INC COM 252131107 28,343 69,914 SH   OTR 2 69,914 0 0
DIAMONDBACK ENERGY INC COM 25278X109 10,592 253,285 SH   DFND 1 253,195 0 90
DIAMONDROCK HOSPITALITY CO COM 252784301 691 125,033 SH   DFND 1 125,033 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 537 21,143 SH   DFND 1 21,143 0 0
DISNEY WALT CO COM DISNEY 254687106 80,030 717,690 SH   DFND 1 717,690 0 0
DOCUSIGN INC COM 256163106 1,311 7,615 SH   DFND 1 7,615 0 0
DOLLAR GEN CORP NEW COM 256677105 54,281 284,927 SH   DFND 1 283,783 0 1,144
DOMINION ENERGY INC COM 25746U109 288,395 3,552,534 SH   DFND 1 3,552,534 0 0
DOUGLAS EMMETT INC COM 25960P109 9,083 296,255 SH   DFND 1 296,255 0 0
DOW INC COM 260557103 33,547 823,026 SH   DFND 1 822,991 0 35
DTE ENERGY CO COM 233331107 54,133 503,559 SH   DFND 1 503,559 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 47,376 593,011 SH   DFND 1 593,011 0 0
DUNKIN BRANDS GROUP INC COM 265504100 21,288 326,348 SH   DFND 1 324,928 0 1,420
DYNATRACE INC COM 268150109 224,013 5,517,550 SH   DFND 1 5,001,192 0 516,358
DYNATRACE INC COM 268150109 22,562 555,725 SH   OTR 2 555,725 0 0
EAST WEST BANCORP INC COM 27579R104 33,253 917,572 SH   DFND 1 917,572 0 0
EAST WEST BANCORP INC COM 27579R104 6,148 169,652 SH   OTR 2 169,652 0 0
EBAY INC. COM 278642103 1,336 25,479 SH   DFND 1 25,479 0 0
EDISON INTL COM 281020107 78,454 1,444,551 SH   DFND 1 1,444,551 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 183,982 2,662,156 SH   DFND 1 2,315,085 0 347,071
EDWARDS LIFESCIENCES CORP COM 28176E108 8,439 122,113 SH   OTR 2 122,113 0 0
EHEALTH INC COM 28238P109 11,830 120,421 SH   DFND 1 120,421 0 0
EL PASO ELEC CO COM NEW 283677854 7,024 104,835 SH   DFND 1 104,835 0 0
EL PASO ELEC CO COM NEW 283677854 3,132 46,748 SH   OTR 2 46,748 0 0
EMCOR GROUP INC COM 29084Q100 582 8,797 SH   DFND 1 8,797 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 30,503 385,732 SH   DFND 1 385,732 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 5,121 64,752 SH   OTR 2 64,752 0 0
EMERSON ELEC CO COM 291011104 56,356 908,535 SH   DFND 1 908,535 0 0
EMPLOYERS HOLDINGS INC COM 292218104 270 8,959 SH   DFND 1 8,959 0 0
ENBRIDGE INC COM 29250N105 60,653 1,994,150 SH   DFND 1 1,994,150 0 0
ENERGY TRANSFER LP COM UT LTD PTN 29273V100 10,976 1,541,642 SH   DFND 1 1,541,642 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 12,281 697,728 SH   DFND 1 697,728 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 4,088 232,301 SH   OTR 2 232,301 0 0
ENPHASE ENERGY INC COM 29355A107 1,311 27,552 SH   DFND 1 27,552 0 0
ENTERGY CORP NEW COM 29364G103 116,421 1,241,031 SH   DFND 1 1,241,031 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 10,704 343,959 SH   DFND 1 343,959 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 2,595 83,379 SH   OTR 2 83,379 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 22,224 1,223,142 SH   DFND 1 1,223,142 0 0
EOG RES INC COM 26875P101 6,849 135,191 SH   DFND 1 135,139 0 52
EQUINIX INC COM 29444U700 123,808 176,290 SH   DFND 1 176,176 0 114
EQUITRANS MIDSTREAM CORP COM 294600101 12,015 1,445,857 SH   DFND 1 1,445,857 0 0
ESSENT GROUP LTD COM G3198U102 729 20,111 SH   DFND 1 20,111 0 0
ESSENTIAL UTILS INC COM 29670G102 94,908 2,246,864 SH   DFND 1 2,246,864 0 0
ETSY INC COM 29786A106 59,767 562,619 SH   DFND 1 560,852 0 1,767
EVERBRIDGE INC COM 29978A104 35,467 256,338 SH   DFND 1 256,338 0 0
EVERBRIDGE INC COM 29978A104 7,016 50,706 SH   OTR 2 50,706 0 0
EVERSOURCE ENERGY COM 30040W108 36,417 437,341 SH   DFND 1 437,341 0 0
EVERTEC INC COM 30040P103 801 28,509 SH   DFND 1 28,509 0 0
EVO PMTS INC CL A COM 26927E104 8,921 390,771 SH   DFND 1 390,771 0 0
EVO PMTS INC CL A COM 26927E104 3,239 141,871 SH   OTR 2 141,871 0 0
EXELON CORP COM 30161N101 32,261 888,983 SH   DFND 1 888,983 0 0
F M C CORP COM NEW 302491303 141,047 1,415,854 SH   DFND 1 1,413,854 0 2,000
FACEBOOK INC CL A 30303M102 3,307,397 14,565,541 SH   DFND 1 13,961,951 0 603,590
FACEBOOK INC CL A 30303M102 54,895 241,752 SH   OTR 2 241,752 0 0
FAIR ISAAC CORP COM 303250104 4,329 10,355 SH   DFND 1 10,355 0 0
FATE THERAPEUTICS INC COM 31189P102 34,736 1,012,425 SH   DFND 1 1,012,425 0 0
FEDERAL SIGNAL CORP COM 313855108 720 24,233 SH   DFND 1 24,233 0 0
FEDERATED HERMES INC CL B 314211103 1,049 44,250 SH   DFND 1 44,250 0 0
FERRARI N V COM N3167Y103 17,737 103,721 SH   DFND 1 102,249 0 1,472
FIDELITY NATL INFORMATION SV COM 31620M106 25,764 192,143 SH   DFND 1 191,278 0 865
FIRST BANCORP N C COM 318910106 14,238 567,716 SH   DFND 1 567,716 0 0
FIRST BANCORP N C COM 318910106 4,497 179,309 SH   OTR 2 179,309 0 0
FIRST FINL BANCORP OH COM 320209109 449 32,343 SH   DFND 1 32,343 0 0
FIRST FNDTN INC COM 32026V104 13,437 822,317 SH   DFND 1 822,317 0 0
FIRST FNDTN INC COM 32026V104 3,194 195,488 SH   OTR 2 195,488 0 0
FIRSTENERGY CORP COM 337932107 154,159 3,975,211 SH   DFND 1 3,975,211 0 0
FISERV INC COM 337738108 32,105 328,878 SH   DFND 1 327,535 0 1,343
FIVE BELOW INC COM 33829M101 82,117 768,098 SH   DFND 1 766,424 0 1,674
FIVE BELOW INC COM 33829M101 5,586 52,245 SH   OTR 2 52,245 0 0
FIVE9 INC COM 338307101 8,171 73,828 SH   DFND 1 73,828 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 28,492 113,273 SH   DFND 1 112,895 0 378
FOCUS FINL PARTNERS INC COM CL A 34417P100 15,633 473,011 SH   DFND 1 473,011 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 2,288 69,229 SH   OTR 2 69,229 0 0
FORTINET INC COM 34959E109 2,981 21,719 SH   DFND 1 21,719 0 0
FREEPORT-MCMORAN INC CL B 35671D857 8,582 741,745 SH   DFND 1 741,483 0 262
FRESHPET INC COM 358039105 17,241 206,094 SH   DFND 1 206,094 0 0
FRESHPET INC COM 358039105 5,554 66,383 SH   OTR 2 66,383 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 28,132 813,059 SH   DFND 1 813,059 0 0
GENERAL MTRS CO COM 37045V100 59,608 2,356,060 SH   DFND 1 2,356,060 0 0
GENERATION BIO CO COM 37148K100 515 24,526 SH   DFND 1 24,526 0 0
GENETRON HLDGS LTD ADS 37186H100 9,117 755,367 SH   DFND 1 755,367 0 0
GENMAB A/S SPONSORED ADS 372303206 20,235 597,089 SH   DFND 1 597,089 0 0
GFL ENVIRONMENTAL INC SUB VTG SHS 36168Q104 45,073 2,401,347 SH   DFND 1 2,394,980 0 6,367
GFL ENVIRONMENTAL INC UNIT 99/99/9999T 36168Q120 22,072 452,952 SH   DFND 1 452,952 0 0
GLAUKOS CORP COM 377322102 5,850 152,253 SH   DFND 1 152,253 0 0
GLAUKOS CORP COM 377322102 2,115 55,057 SH   OTR 2 55,057 0 0
GLOBAL PMTS INC COM 37940X102 45,221 266,601 SH   DFND 1 265,443 0 1,158
GLOBANT S A COM L44385109 40,895 272,906 SH   DFND 1 272,374 0 532
GLOBANT S A COM L44385109 3,498 23,345 SH   OTR 2 23,345 0 0
GMS INC COM 36251C103 601 24,458 SH   DFND 1 24,458 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 1,067,486 5,401,711 SH   DFND 1 5,131,501 0 270,210
GOLDMAN SACHS GROUP INC COM 38141G104 11,400 57,687 SH   OTR 2 57,687 0 0
GOOSEHEAD INS INC COM CL A 38267D109 23,874 317,645 SH   DFND 1 317,645 0 0
GOOSEHEAD INS INC COM CL A 38267D109 7,662 101,943 SH   OTR 2 101,943 0 0
GOSSAMER BIO INC COM 38341P102 19,127 1,471,308 SH   DFND 1 1,471,308 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 37,079 4,004,269 SH   DFND 1 4,004,269 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 5,424 585,741 SH   OTR 2 585,741 0 0
GUARDANT HEALTH INC COM 40131M109 265,842 3,276,734 SH   DFND 1 3,180,064 0 96,670
GUARDANT HEALTH INC COM 40131M109 4,744 58,475 SH   OTR 2 58,475 0 0
GUIDEWIRE SOFTWARE INC COM 40171V100 24,324 219,430 SH   DFND 1 218,482 0 948
HAMILTON LANE INC CL A 407497106 562 8,349 SH   DFND 1 8,349 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 2,733 96,019 SH   DFND 1 95,982 0 37
HARSCO CORP COM 415864107 17,339 1,283,369 SH   DFND 1 1,283,369 0 0
HARSCO CORP COM 415864107 3,048 225,630 SH   OTR 2 225,630 0 0
HCA HEALTHCARE INC COM 40412C101 1,128 11,626 SH   DFND 1 11,626 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 8,397 343,330 SH   DFND 1 343,330 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 1,983 81,053 SH   OTR 2 81,053 0 0
HEALTHEQUITY INC COM 42226A107 11,328 193,088 SH   DFND 1 193,088 0 0
HEALTHEQUITY INC COM 42226A107 3,752 63,944 SH   OTR 2 63,944 0 0
HENRY JACK & ASSOC INC COM 426281101 1,831 9,952 SH   DFND 1 9,952 0 0
HESS CORP COM 42809H107 9,097 175,583 SH   DFND 1 175,519 0 64
HILL ROM HLDGS INC COM 431475102 47,440 432,141 SH   DFND 1 430,941 0 1,200
HILLTOP HOLDINGS INC COM 432748101 1,252 67,832 SH   DFND 1 67,832 0 0
HOME DEPOT INC COM 437076102 1,465,974 5,851,959 SH   DFND 1 5,587,596 0 264,363
HOME DEPOT INC COM 437076102 15,093 60,248 SH   OTR 2 60,248 0 0
HONEYWELL INTL INC COM 438516106 2,421 16,743 SH   DFND 1 16,743 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 56,949 1,024,628 SH   DFND 1 1,024,628 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 5,712 102,766 SH   OTR 2 102,766 0 0
HOULIHAN LOKEY INC CL A 441593100 17,809 320,061 SH   DFND 1 320,061 0 0
HOULIHAN LOKEY INC CL A 441593100 5,736 103,097 SH   OTR 2 103,097 0 0
HOWARD HUGHES CORP COM 44267D107 8,508 163,771 SH   DFND 1 163,771 0 0
HUB GROUP INC CL A 443320106 437 9,138 SH   DFND 1 9,138 0 0
HUBSPOT INC COM 443573100 97,850 436,150 SH   DFND 1 435,400 0 750
HUBSPOT INC COM 443573100 5,308 23,658 SH   OTR 2 23,658 0 0
HUMANA INC COM 444859102 383,216 988,308 SH   DFND 1 907,465 0 80,843
HUMANA INC COM 444859102 2,892 7,458 SH   OTR 2 7,458 0 0
HUNT J B TRANS SVCS INC COM 445658107 47,014 390,675 SH   DFND 1 389,391 0 1,284
HURON CONSULTING GROUP INC COM 447462102 10,145 229,254 SH   DFND 1 229,254 0 0
HURON CONSULTING GROUP INC COM 447462102 3,679 83,142 SH   OTR 2 83,142 0 0
IDEX CORP COM 45167R104 23,608 149,380 SH   DFND 1 148,730 0 650
IHS MARKIT LTD SHS G47567105 44,315 586,958 SH   DFND 1 584,519 0 2,439
ILLUMINA INC COM 452327109 628,954 1,698,269 SH   DFND 1 1,614,175 0 84,094
ILLUMINA INC COM 452327109 5,678 15,332 SH   OTR 2 15,332 0 0
IMMUNOMEDICS INC CALL OPTIONS 452907108 7,088 200,000 SH Call DFND 1 0 0 0
IMMUNOMEDICS INC COM 452907108 104,734 2,955,223 SH   DFND 1 2,953,722 0 1,501
IMMUNOMEDICS INC COM 452907108 5,387 152,017 SH   OTR 2 152,017 0 0
INARI MED INC COM 45332Y109 1,976 40,791 SH   DFND 1 40,791 0 0
INARI MED INC COM 45332Y109 191 3,942 SH   OTR 2 3,942 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 18,881 1,643,236 SH   DFND 1 1,643,236 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 5,928 515,912 SH   OTR 2 515,912 0 0
INOVALON HLDGS INC COM CL A 45781D101 700 36,337 SH   DFND 1 36,337 0 0
INPHI CORP COM 45772F107 41,409 352,420 SH   DFND 1 352,420 0 0
INPHI CORP COM 45772F107 13,244 112,712 SH   OTR 2 112,712 0 0
INSPIRE MED SYS INC COM 457730109 14,741 169,401 SH   DFND 1 169,401 0 0
INSPIRE MED SYS INC COM 457730109 4,618 53,064 SH   OTR 2 53,064 0 0
INSULET CORP COM 45784P101 31,490 162,101 SH   DFND 1 161,627 0 474
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 19,041 405,215 SH   DFND 1 405,215 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 3,190 67,888 SH   OTR 2 67,888 0 0
INTEL CORP COM 458140100 14,442 241,379 SH   DFND 1 241,379 0 0
INTERNATIONAL BANCSHARES COR COM 459044103 1,639 51,187 SH   DFND 1 51,187 0 0
INTERSECT ENT INC COM 46071F103 6,595 487,133 SH   DFND 1 487,133 0 0
INTERSECT ENT INC COM 46071F103 2,018 149,012 SH   OTR 2 149,012 0 0
INTUIT COM 461202103 763 2,577 SH   DFND 1 2,577 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 519,177 911,110 SH   DFND 1 849,988 0 61,122
INTUITIVE SURGICAL INC COM NEW 46120E602 3,579 6,280 SH   OTR 2 6,280 0 0
INVITAE CORP COM 46185L103 11,886 392,396 SH   DFND 1 392,396 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 9,477 345,239 SH   DFND 1 345,239 0 0
IQVIA HLDGS INC COM 46266C105 54,625 385,010 SH   DFND 1 383,914 0 1,096
ISHARES TR RUS 1000 GRW ETF 464287614 1,196 6,230 SH   DFND 1 5,691 0 539
ISTAR INC COM 45031U101 1,263 102,530 SH   DFND 1 102,530 0 0
ITRON INC COM 465741106 1,050 15,846 SH   DFND 1 15,846 0 0
JACK IN THE BOX INC COM 466367109 39,997 539,851 SH   DFND 1 539,851 0 0
JACK IN THE BOX INC COM 466367109 8,070 108,915 SH   OTR 2 108,915 0 0
JD.COM INC SPON ADR CL A 47215P106 1,963 32,613 SH   DFND 1 32,613 0 0
JELD-WEN HLDG INC COM 47580P103 5,440 337,693 SH   DFND 1 337,693 0 0
JELD-WEN HLDG INC COM 47580P103 1,671 103,728 SH   OTR 2 103,728 0 0
JOHNSON & JOHNSON COM 478160104 1,812 12,883 SH   DFND 1 12,883 0 0
JOHNSON CTLS INTL PLC SHS G51502105 92,232 2,701,584 SH   DFND 1 2,701,584 0 0
JPMORGAN CHASE & CO COM 46625H100 224,495 2,386,720 SH   DFND 1 2,386,720 0 0
KAMAN CORP COM 483548103 6,192 148,840 SH   DFND 1 148,840 0 0
KAMAN CORP COM 483548103 2,279 54,785 SH   OTR 2 54,785 0 0
KB HOME COM 48666K109 2,855 93,043 SH   DFND 1 93,043 0 0
KENNAMETAL INC COM 489170100 11,047 384,760 SH   DFND 1 384,760 0 0
KENNAMETAL INC COM 489170100 2,791 97,226 SH   OTR 2 97,226 0 0
KENNEDY-WILSON HOLDINGS INC COM 489398107 1,143 75,079 SH   DFND 1 75,079 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 451 4,479 SH   DFND 1 4,479 0 0
KINDER MORGAN INC DEL COM 49456B101 35,690 2,352,676 SH   DFND 1 2,352,398 0 278
KINROSS GOLD CORP COM 496902404 15,392 2,131,887 SH   DFND 1 2,131,106 0 781
KIRBY CORP COM 497266106 2,306 43,063 SH   DFND 1 43,047 0 16
KKR & CO INC COM 48251W104 5,540 179,400 SH   DFND 1 179,400 0 0
KLA CORP COM NEW 482480100 2,793 14,362 SH   DFND 1 14,362 0 0
KONTOOR BRANDS INC COM 50050N103 9,736 546,629 SH   DFND 1 546,629 0 0
KONTOOR BRANDS INC COM 50050N103 2,929 164,484 SH   OTR 2 164,484 0 0
KORN FERRY COM NEW 500643200 27,574 897,300 SH   DFND 1 897,300 0 0
KORN FERRY COM NEW 500643200 4,495 146,273 SH   OTR 2 146,273 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 38,424 226,465 SH   DFND 1 225,496 0 969
LABORATORY CORP AMER HLDGS COM NEW 50540R409 91,602 551,456 SH   DFND 1 551,456 0 0
LAM RESEARCH CORP COM 512807108 64,393 199,076 SH   DFND 1 198,473 0 603
LAMB WESTON HLDGS INC COM 513272104 15,674 245,174 SH   DFND 1 244,123 0 1,051
LATTICE SEMICONDUCTOR CORP COM 518415104 22,878 805,840 SH   DFND 1 805,840 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 4,883 171,995 SH   OTR 2 171,995 0 0
LAUDER ESTEE COS INC CL A 518439104 1,060,719 5,621,785 SH   DFND 1 5,331,213 0 290,572
LAUDER ESTEE COS INC CL A 518439104 14,621 77,493 SH   OTR 2 77,493 0 0
LAZARD LTD SHS A G54050102 15,370 536,863 SH   DFND 1 536,863 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 5,746 135,000 SH   DFND 1 135,000 0 0
LEXINGTON REALTY TRUST COM 529043101 1,777 168,450 SH   DFND 1 168,450 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 5,714 51,090 SH   DFND 1 51,090 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 2,133 19,067 SH   OTR 2 19,067 0 0
LILLY ELI & CO COM 532457108 1,309,586 7,976,528 SH   DFND 1 7,687,314 0 289,214
LILLY ELI & CO COM 532457108 14,258 86,844 SH   OTR 2 86,844 0 0
LIMELIGHT NETWORKS INC COM 53261M104 632 85,912 SH   DFND 1 85,912 0 0
LINCOLN NATL CORP IND COM 534187109 1,346 36,579 SH   DFND 1 36,579 0 0
LINDE PLC SHS G5494J103 196,909 928,334 SH   DFND 1 928,308 0 26
LITTELFUSE INC COM 537008104 18,023 105,629 SH   DFND 1 105,629 0 0
LITTELFUSE INC COM 537008104 4,235 24,817 SH   OTR 2 24,817 0 0
LIVERAMP HLDGS INC COM 53815P108 18,022 424,351 SH   DFND 1 424,351 0 0
LIVERAMP HLDGS INC COM 53815P108 4,685 110,313 SH   OTR 2 110,313 0 0
LIVONGO HEALTH INC COM 539183103 56,265 748,306 SH   DFND 1 748,306 0 0
LIVONGO HEALTH INC COM 539183103 15,652 208,166 SH   OTR 2 208,166 0 0
LOCKHEED MARTIN CORP COM 539830109 8,785 24,075 SH   DFND 1 24,075 0 0
LOWES COS INC COM 548661107 140,169 1,037,367 SH   DFND 1 1,037,367 0 0
LTC PPTYS INC COM 502175102 439 11,656 SH   DFND 1 11,656 0 0
LULULEMON ATHLETICA INC COM 550021109 2,577,494 8,260,935 SH   DFND 1 7,922,838 0 338,097
LULULEMON ATHLETICA INC COM 550021109 56,072 179,711 SH   OTR 2 179,711 0 0
LUMINEX CORP DEL COM 55027E102 734 22,575 SH   DFND 1 22,575 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 18,348 162,019 SH   DFND 1 162,019 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 1,761 15,546 SH   OTR 2 15,546 0 0
MAG SILVER CORP COM 55903Q104 5,629 398,761 SH   DFND 1 398,608 0 153
MAGELLAN HEALTH INC COM NEW 559079207 508 6,960 SH   DFND 1 6,960 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 12,703 294,263 SH   DFND 1 294,263 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 1,313 85,710 SH   DFND 1 85,710 0 0
MALIBU BOATS INC COM CL A 56117J100 313 6,033 SH   DFND 1 6,033 0 0
MANTECH INTL CORP CL A 564563104 430 6,285 SH   DFND 1 6,285 0 0
MARATHON PETE CORP COM 56585A102 3,635 97,237 SH   DFND 1 97,199 0 38
MARSH & MCLENNAN COS INC COM 571748102 60,698 565,312 SH   DFND 1 565,312 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 81,268 2,317,966 SH   DFND 1 2,310,615 0 7,351
MASIMO CORP COM 574795100 1,356 5,949 SH   DFND 1 5,949 0 0
MASONITE INTL CORP NEW COM 575385109 842 10,830 SH   DFND 1 10,830 0 0
MASTERCARD INCORPORATED CL A 57636Q104 3,264,017 11,038,271 SH   DFND 1 10,561,896 0 476,375
MASTERCARD INCORPORATED CL A 57636Q104 66,381 224,489 SH   OTR 2 224,489 0 0
MATCH GROUP INC COM 57665R106 214,004 1,999,105 SH   DFND 1 1,912,664 0 86,441
MATCH GROUP INC COM 57665R106 11,388 106,378 SH   OTR 2 106,378 0 0
MAXAR TECHNOLOGIES INC COM 57778K105 971 54,064 SH   DFND 1 54,064 0 0
MAXIMUS INC COM 577933104 1,079 15,312 SH   DFND 1 15,312 0 0
MAXLINEAR INC COM 57776J100 15,531 723,760 SH   DFND 1 723,760 0 0
MAXLINEAR INC COM 57776J100 5,474 255,057 SH   OTR 2 255,057 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 4,379 554,273 SH   DFND 1 554,273 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 1,597 202,174 SH   OTR 2 202,174 0 0
MCDONALDS CORP COM 580135101 63,202 342,616 SH   DFND 1 342,616 0 0
MCKESSON CORP COM 58155Q103 4,508 29,384 SH   DFND 1 29,384 0 0
MEDPACE HLDGS INC COM 58506Q109 931 10,013 SH   DFND 1 10,013 0 0
MERCADOLIBRE INC COM 58733R102 845,826 858,036 SH   DFND 1 814,118 0 43,918
MERCADOLIBRE INC COM 58733R102 46,611 47,284 SH   OTR 2 47,284 0 0
MERCK & CO. INC COM 58933Y105 10,209 132,024 SH   DFND 1 132,024 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 541 23,226 SH   DFND 1 23,226 0 0
MERITAGE HOMES CORP COM 59001A102 1,636 21,492 SH   DFND 1 21,492 0 0
MERITOR INC COM 59001K100 440 22,224 SH   DFND 1 22,224 0 0
META FINL GROUP INC COM 59100U108 715 39,375 SH   DFND 1 39,375 0 0
METHODE ELECTRS INC COM 591520200 1,579 50,522 SH   DFND 1 50,522 0 0
METLIFE INC COM 59156R108 124,419 3,406,870 SH   DFND 1 3,406,870 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 35,224 334,475 SH   DFND 1 333,099 0 1,376
MICROSOFT CORP COM 594918104 5,941,512 29,195,183 SH   DFND 1 28,081,474 0 1,113,709
MICROSOFT CORP COM 594918104 99,529 489,063 SH   OTR 2 489,063 0 0
MIRATI THERAPEUTICS INC COM 60468T105 54,261 475,270 SH   DFND 1 475,270 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,332 29,181 SH   OTR 2 29,181 0 0
MOBILE MINI INC COM 60740F105 37,388 1,267,364 SH   DFND 1 1,267,364 0 0
MOBILE MINI INC COM 60740F105 6,223 210,961 SH   OTR 2 210,961 0 0
MODEL N INC COM 607525102 1,629 46,860 SH   DFND 1 46,860 0 0
MOELIS & CO CL A 60786M105 30,948 993,198 SH   DFND 1 993,198 0 0
MOELIS & CO CL A 60786M105 4,979 159,787 SH   OTR 2 159,787 0 0
MOLINA HEALTHCARE INC COM 60855R100 69,002 387,695 SH   DFND 1 386,597 0 1,098
MOMENTA PHARMACEUTICALS INC COM 60877T100 20,191 606,894 SH   DFND 1 606,894 0 0
MONDELEZ INTL INC CL A 609207105 188,541 3,687,489 SH   DFND 1 3,235,644 0 451,845
MONOLITHIC PWR SYS INC COM 609839105 48,591 205,026 SH   DFND 1 204,525 0 501
MONRO INC COM 610236101 8,418 153,210 SH   DFND 1 153,210 0 0
MONRO INC COM 610236101 3,059 55,686 SH   OTR 2 55,686 0 0
MPLX LP COM UNIT REP LTD 55336V100 20,021 1,158,650 SH   DFND 1 1,158,650 0 0
MSCI INC COM 55354G100 1,384 4,147 SH   DFND 1 4,147 0 0
MUELLER WTR PRODS INC COM SER A 624758108 9,010 955,478 SH   DFND 1 955,478 0 0
MUELLER WTR PRODS INC COM SER A 624758108 2,531 268,406 SH   OTR 2 268,406 0 0
MYOKARDIA INC COM 62857M105 10,981 113,654 SH   DFND 1 113,654 0 0
NATERA INC COM 632307104 108,874 2,183,613 SH   DFND 1 2,183,613 0 0
NATERA INC COM 632307104 8,233 165,113 SH   OTR 2 165,113 0 0
NATIONAL ENERGY SERVICES REU SHS G6375R107 5,671 824,340 SH   DFND 1 824,019 0 321
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 17,814 621,551 SH   DFND 1 621,551 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 5,389 188,042 SH   OTR 2 188,042 0 0
NATIONAL VISION HLDGS INC COM 63845R107 14,078 461,273 SH   DFND 1 461,273 0 0
NATIONAL VISION HLDGS INC COM 63845R107 4,617 151,272 SH   OTR 2 151,272 0 0
NEOGENOMICS INC COM NEW 64049M209 9,270 299,229 SH   DFND 1 299,229 0 0
NEOGENOMICS INC COM NEW 64049M209 2,989 96,470 SH   OTR 2 96,470 0 0
NETFLIX INC COM 64110L106 4,055,315 8,911,996 SH   DFND 1 8,486,687 0 425,309
NETFLIX INC COM 64110L106 85,169 187,169 SH   OTR 2 187,169 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 41,707 341,858 SH   DFND 1 341,402 0 456
NEVRO CORP COM 64157F103 14,368 120,270 SH   DFND 1 120,270 0 0
NEVRO CORP COM 64157F103 4,756 39,807 SH   OTR 2 39,807 0 0
NEW JERSEY RES COM 646025106 507 15,531 SH   DFND 1 15,531 0 0
NEWMONT CORP COM 651639106 24,308 393,722 SH   DFND 1 393,594 0 128
NEXPOINT RESIDENTIAL TR INC COM 65341D102 1,441 40,774 SH   DFND 1 40,774 0 0
NEXSTAR MEDIA GROUP INC CL A 65336K103 2,191 26,180 SH   DFND 1 26,180 0 0
NEXTCURE INC COM 65343E108 9,999 466,364 SH   DFND 1 466,364 0 0
NEXTERA ENERGY INC COM 65339F101 269,239 1,121,037 SH   DFND 1 1,121,037 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 175,053 3,413,665 SH   DFND 1 3,413,574 0 91
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 9,164 178,706 SH   OTR 2 178,706 0 0
NIC INC COM 62914B100 368 16,007 SH   DFND 1 16,007 0 0
NICE LTD SPONSORED ADR 653656108 44,813 236,807 SH   DFND 1 236,781 0 26
NIKE INC CL B 654106103 1,267,603 12,928,125 SH   DFND 1 12,251,733 0 676,392
NIKE INC CL B 654106103 12,530 127,796 SH   OTR 2 127,796 0 0
NISOURCE INC COM 65473P105 43,320 1,904,992 SH   DFND 1 1,904,992 0 0
NLIGHT INC COM 65487K100 21,142 949,762 SH   DFND 1 949,762 0 0
NLIGHT INC COM 65487K100 4,887 219,535 SH   OTR 2 219,535 0 0
NOBLE ENERGY INC COM 655044105 5,903 658,824 SH   DFND 1 658,593 0 231
NORDSON CORP COM 655663102 31,862 167,949 SH   DFND 1 167,353 0 596
NORFOLK SOUTHERN CORP COM 655844108 9,499 54,104 SH   DFND 1 54,104 0 0
NORTHROP GRUMMAN CORP COM 666807102 70,971 230,845 SH   DFND 1 230,845 0 0
NORTHWESTERN CORP COM NEW 668074305 451 8,273 SH   DFND 1 8,273 0 0
NOVO-NORDISK A S ADR 670100205 65,141 994,830 SH   DFND 1 994,715 0 115
NUTRIEN LTD COM 67077M108 4,225 131,625 SH   DFND 1 131,570 0 55
NVIDIA CORPORATION COM 67066G104 2,906,943 7,651,661 SH   DFND 1 7,295,951 0 355,710
NVIDIA CORPORATION COM 67066G104 51,231 134,851 SH   OTR 2 134,851 0 0
OFFICE DEPOT INC COM 676220106 702 298,622 SH   DFND 1 298,622 0 0
OKTA INC CL A 679295105 22,246 111,103 SH   DFND 1 111,103 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 1,346 7,939 SH   DFND 1 7,939 0 0
ON SEMICONDUCTOR CORP COM 682189105 11,716 591,105 SH   DFND 1 591,105 0 0
ONE GAS INC COM 68235P108 634 8,234 SH   DFND 1 8,234 0 0
ONEOK INC NEW COM 682680103 11,956 359,890 SH   DFND 1 359,890 0 0
ORACLE CORP COM 68389X105 5,399 97,681 SH   DFND 1 97,681 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 542 46,564 SH   DFND 1 46,564 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 44,167 104,742 SH   DFND 1 104,281 0 461
ORIC PHARMACEUTICALS INC COM 68622P109 5,061 150,058 SH   DFND 1 150,058 0 0
OTIS WORLDWIDE CORP COM 68902V107 60,602 1,065,803 SH   DFND 1 1,065,803 0 0
PACIFIC PREMIER BANCORP COM 69478X105 1,130 52,134 SH   DFND 1 52,134 0 0
PALO ALTO NETWORKS INC COM 697435105 26,899 117,121 SH   DFND 1 116,603 0 518
PARSLEY ENERGY INC CL A 701877102 11,919 1,115,968 SH   DFND 1 1,115,554 0 414
PATRICK INDS INC COM 703343103 554 9,046 SH   DFND 1 9,046 0 0
PAYCOM SOFTWARE INC COM 70432V102 23,639 76,322 SH   DFND 1 76,120 0 202
PAYLOCITY HLDG CORP COM 70438V106 1,423 9,756 SH   DFND 1 9,756 0 0
PAYPAL HLDGS INC COM 70450Y103 1,961,974 11,260,824 SH   DFND 1 10,779,545 0 481,279
PAYPAL HLDGS INC COM 70450Y103 22,317 128,091 SH   OTR 2 128,091 0 0
PDC ENERGY INC COM 69327R101 1,785 143,477 SH   DFND 1 143,421 0 56
PEMBINA PIPELINE CORP COM 706327103 20,418 816,642 SH   DFND 1 816,642 0 0
PENN NATL GAMING INC COM 707569109 32,980 1,079,906 SH   DFND 1 1,079,906 0 0
PENN NATL GAMING INC COM 707569109 6,248 204,572 SH   OTR 2 204,572 0 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 593 14,201 SH   DFND 1 14,201 0 0
PENTAIR PLC SHS G7S00T104 13,134 345,730 SH   DFND 1 345,730 0 0
PEPSICO INC COM 713448108 99,316 750,917 SH   DFND 1 750,917 0 0
PERFICIENT INC COM 71375U101 1,629 45,535 SH   DFND 1 45,535 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 50,203 1,722,825 SH   DFND 1 1,722,825 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 8,197 281,307 SH   OTR 2 281,307 0 0
PETMED EXPRESS INC COM 716382106 806 22,602 SH   DFND 1 22,602 0 0
PHILIP MORRIS INTL INC COM 718172109 687 9,804 SH   DFND 1 9,804 0 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 14,237 395,031 SH   DFND 1 395,031 0 0
PHREESIA INC COM 71944F106 23,999 848,620 SH   DFND 1 848,620 0 0
PHREESIA INC COM 71944F106 3,676 129,970 SH   OTR 2 129,970 0 0
PHYSICIANS RLTY TR COM 71943U104 16,121 920,175 SH   DFND 1 920,175 0 0
PHYSICIANS RLTY TR COM 71943U104 2,846 162,420 SH   OTR 2 162,420 0 0
PIEDMONT OFFICE REALTY TR IN COM CL A 720190206 1,763 106,144 SH   DFND 1 106,144 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 34,868 830,390 SH   DFND 1 830,390 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 5,397 128,529 SH   OTR 2 128,529 0 0
PINTEREST INC CL A 72352L106 36,452 1,644,203 SH   DFND 1 1,639,022 0 5,181
PIONEER NAT RES CO COM 723787107 6,829 69,893 SH   DFND 1 69,868 0 25
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 7,274 822,863 SH   DFND 1 822,863 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 4,628 519,998 SH   DFND 1 519,998 0 0
PLANET FITNESS INC CL A 72703H101 20,192 333,376 SH   DFND 1 333,376 0 0
PLANET FITNESS INC CL A 72703H101 3,556 58,704 SH   OTR 2 58,704 0 0
PLURALSIGHT INC COM CL A 72941B106 8,518 471,937 SH   DFND 1 471,937 0 0
PLURALSIGHT INC COM CL A 72941B106 1,630 90,279 SH   OTR 2 90,279 0 0
PNC FINL SVCS GROUP INC COM 693475105 125,436 1,192,245 SH   DFND 1 1,192,245 0 0
PNM RES INC COM 69349H107 21,480 558,774 SH   DFND 1 558,774 0 0
PNM RES INC COM 69349H107 3,712 96,575 SH   OTR 2 96,575 0 0
POLYONE CORP COM 73179P106 47,620 1,815,465 SH   DFND 1 1,815,465 0 0
POLYONE CORP COM 73179P106 7,039 268,363 SH   OTR 2 268,363 0 0
PORTLAND GEN ELEC CO COM NEW 736508847 613 14,659 SH   DFND 1 14,659 0 0
POWER INTEGRATIONS INC COM 739276103 1,793 15,175 SH   DFND 1 15,175 0 0
PPD INC COM 69355F102 41,725 1,556,921 SH   DFND 1 1,551,939 0 4,982
PPL CORP COM 69351T106 25,548 988,709 SH   DFND 1 988,709 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 15,335 408,281 SH   DFND 1 408,281 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 4,632 123,335 SH   OTR 2 123,335 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 911 61,161 SH   DFND 1 61,161 0 0
PROCTER AND GAMBLE CO COM 742718109 96,127 803,941 SH   DFND 1 803,941 0 0
PROLOGIS INC. COM 74340W103 30,150 323,048 SH   DFND 1 323,048 0 0
PROOFPOINT INC COM 743424103 19,094 171,831 SH   DFND 1 171,831 0 0
PROOFPOINT INC COM 743424103 6,331 56,973 SH   OTR 2 56,973 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 15,963 2,625,514 SH   DFND 1 2,625,514 0 0
PROSIGHT GLOBAL INC COM 74349J103 4,482 503,568 SH   DFND 1 503,568 0 0
PROSIGHT GLOBAL INC COM 74349J103 669 75,190 SH   OTR 2 75,190 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 57,515 1,169,964 SH   DFND 1 1,169,964 0 0
PURPLE INNOVATION INC COM 74640Y106 493 27,399 SH   DFND 1 27,399 0 0
Q2 HLDGS INC COM 74736L109 29,927 348,843 SH   DFND 1 348,843 0 0
Q2 HLDGS INC COM 74736L109 9,437 110,001 SH   OTR 2 110,001 0 0
QTS RLTY TR INC COM CL A 74736A103 52,647 821,457 SH   DFND 1 821,457 0 0
QTS RLTY TR INC COM CL A 74736A103 10,530 164,293 SH   OTR 2 164,293 0 0
QUALCOMM INC COM 747525103 86,527 948,653 SH   DFND 1 948,653 0 0
QUALYS INC COM 74758T303 522 5,020 SH   DFND 1 5,020 0 0
QUANTA SVCS INC COM 74762E102 70,928 1,807,996 SH   DFND 1 1,803,380 0 4,616
QUIDEL CORP COM 74838J101 2,079 9,291 SH   DFND 1 9,291 0 0
RADIAN GROUP INC COM 750236101 778 50,129 SH   DFND 1 50,129 0 0
RADNET INC COM 750491102 381 24,026 SH   DFND 1 24,026 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 92,992 1,509,120 SH   DFND 1 1,509,120 0 0
REGENERON PHARMACEUTICALS COM 75886F107 42,756 68,557 SH   DFND 1 68,557 0 0
RENAISSANCERE HOLDINGS LTD COM G7496G103 46,949 274,507 SH   DFND 1 274,197 0 310
RENASANT CORP COM 75970E107 10,425 418,673 SH   DFND 1 418,673 0 0
RENASANT CORP COM 75970E107 3,208 128,823 SH   OTR 2 128,823 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 2,737 110,458 SH   DFND 1 110,419 0 39
REPLIGEN CORP COM 759916109 24,218 195,920 SH   DFND 1 195,920 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 19,070 1,683,176 SH   DFND 1 1,683,176 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 3,361 296,635 SH   OTR 2 296,635 0 0
REVANCE THERAPEUTICS INC COM 761330109 47,031 1,925,946 SH   DFND 1 1,925,946 0 0
REVANCE THERAPEUTICS INC COM 761330109 4,899 200,595 SH   OTR 2 200,595 0 0
REXNORD CORP COM 76169B102 53,577 1,837,969 SH   DFND 1 1,837,969 0 0
REXNORD CORP COM 76169B102 8,378 287,420 SH   OTR 2 287,420 0 0
REYNOLDS CONSUMER PRODS INC COM 76171L106 393 11,310 SH   DFND 1 11,310 0 0
RINGCENTRAL INC CL A 76680R206 1,365,242 4,790,158 SH   DFND 1 4,544,054 0 246,104
RINGCENTRAL INC CL A 76680R206 43,501 152,628 SH   OTR 2 152,628 0 0
RIO TINTO PLC SPONSORED ADR 767204100 482 8,582 SH   DFND 1 8,525 0 57
ROSS STORES INC COM 778296103 64,459 756,210 SH   DFND 1 756,203 0 7
ROYAL GOLD INC COM 780287108 14,009 112,684 SH   DFND 1 112,684 0 0
S&P GLOBAL INC COM 78409V104 1,149,905 3,490,062 SH   DFND 1 3,339,138 0 150,924
S&P GLOBAL INC COM 78409V104 12,419 37,692 SH   OTR 2 37,692 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,074 218,238 SH   DFND 1 218,238 0 0
SAIA INC COM 78709Y105 70,638 635,352 SH   DFND 1 635,352 0 0
SAIA INC COM 78709Y105 11,581 104,164 SH   OTR 2 104,164 0 0
SALESFORCE COM INC COM 79466L302 2,803,897 14,967,689 SH   DFND 1 14,205,556 0 762,133
SALESFORCE COM INC COM 79466L302 28,312 151,135 SH   OTR 2 151,135 0 0
SALLY BEAUTY HLDGS INC COM 79546E104 657 52,400 SH   DFND 1 52,400 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 11,201 1,164,370 SH   DFND 1 1,164,370 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 3,376 350,905 SH   OTR 2 350,905 0 0
SAP SE SPON ADR 803054204 78,724 562,311 SH   DFND 1 562,311 0 0
SAREPTA THERAPEUTICS INC COM 803607100 93,636 583,981 SH   DFND 1 583,981 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 115,864 388,911 SH   DFND 1 388,185 0 726
SCHLUMBERGER LTD COM 806857108 4,812 261,661 SH   DFND 1 261,553 0 108
SCHWEITZER-MAUDUIT INTL INC COM 808541106 670 20,061 SH   DFND 1 20,061 0 0
SCULPTOR CAP MGMT COM CL A 811246107 1,301 100,622 SH   DFND 1 100,622 0 0
SCULPTOR CAP MGMT COM CL A 811246107 492 38,069 SH   OTR 2 38,069 0 0
SEA LTD SPONSORED ADS 81141R100 106,890 996,732 SH   DFND 1 996,618 0 114
SEACOAST BKG CORP FLA COM NEW 811707801 10,811 529,933 SH   DFND 1 529,933 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 1,878 92,065 SH   OTR 2 92,065 0 0
SEATTLE GENETICS INC COM 812578102 48,874 287,627 SH   DFND 1 286,909 0 718
SELECT MED HLDGS CORP COM 81619Q105 1,719 116,693 SH   DFND 1 116,693 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 304 8,031 SH   DFND 1 7,978 0 53
SELECTQUOTE INC COM 816307300 17,752 700,842 SH   DFND 1 700,842 0 0
SELECTQUOTE INC COM 816307300 1,632 64,435 SH   OTR 2 64,435 0 0
SEMPRA ENERGY 6% PFD CONV A 816851406 14,732 150,742 SH   DFND 1 150,742 0 0
SEMPRA ENERGY COM 816851109 89,916 767,009 SH   DFND 1 767,009 0 0
SERVICE CORP INTL COM 817565104 299 7,679 SH   DFND 1 7,679 0 0
SERVICENOW INC COM 81762P102 817,175 2,017,419 SH   DFND 1 1,963,260 0 54,159
SERVICENOW INC COM 81762P102 8,520 21,033 SH   OTR 2 21,033 0 0
SHIFT4 PMTS INC CL A 82452J109 16,498 464,737 SH   DFND 1 464,737 0 0
SHIFT4 PMTS INC CL A 82452J109 2,948 83,034 SH   OTR 2 83,034 0 0
SHOCKWAVE MED INC COM 82489T104 27,522 581,008 SH   DFND 1 581,008 0 0
SHOPIFY INC CL A 82509L107 3,058,107 3,221,773 SH   DFND 1 3,114,292 0 107,481
SHOPIFY INC CL A 82509L107 74,485 78,471 SH   OTR 2 78,471 0 0
SILK RD MED INC COM 82710M100 58,977 1,407,898 SH   DFND 1 1,407,898 0 0
SILK RD MED INC COM 82710M100 5,313 126,843 SH   OTR 2 126,843 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 1,163 60,522 SH   DFND 1 60,522 0 0
SLM CORP COM 78442P106 42,635 6,064,708 SH   DFND 1 6,064,708 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 1,545 11,133 SH   DFND 1 11,133 0 0
SOUTHERN COPPER CORP COM 84265V105 13,394 336,778 SH   DFND 1 336,649 0 129
SPDR SER TR PUT OPTIONS 78464A870 11,195 100,000 SH Put DFND 1 100,000 0 0
SPDR SER TR S&P METALS MNG 78464A755 3,374 159,244 SH   DFND 1 158,204 0 1,040
SPIRE INC COM 84857L101 538 8,181 SH   DFND 1 8,181 0 0
SPLUNK INC COM 848637104 1,117,226 5,622,680 SH   DFND 1 5,296,690 0 325,990
SPLUNK INC COM 848637104 15,184 76,415 SH   OTR 2 76,415 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 760,558 2,945,732 SH   DFND 1 2,913,555 0 32,177
SPOTIFY TECHNOLOGY S A SHS L8681T102 9,335 36,155 SH   OTR 2 36,155 0 0
SPROUTS FMRS MKT INC COM 85208M102 31,084 1,214,681 SH   DFND 1 1,214,681 0 0
SPROUTS FMRS MKT INC COM 85208M102 3,675 143,604 SH   OTR 2 143,604 0 0
STARWOOD PPTY TR INC COM 85571B105 9,455 632,007 SH   DFND 1 632,007 0 0
STEELCASE INC CL A 858155203 1,572 130,311 SH   DFND 1 130,311 0 0
STIFEL FINL CORP COM 860630102 1,459 30,751 SH   DFND 1 30,751 0 0
STONERIDGE INC COM 86183P102 1,075 52,037 SH   DFND 1 52,037 0 0
STRYKER CORPORATION COM 863667101 634 3,516 SH   DFND 1 3,516 0 0
STURM RUGER & CO INC COM 864159108 801 10,533 SH   DFND 1 10,533 0 0
SUMMIT MATLS INC CL A 86614U100 51,596 3,208,741 SH   DFND 1 3,208,741 0 0
SUMMIT MATLS INC CL A 86614U100 8,838 549,596 SH   OTR 2 549,596 0 0
SUNCOR ENERGY INC NEW COM 867224107 30,563 1,812,772 SH   DFND 1 1,812,540 0 232
SUNNOVA ENERGY INTL INC COM 86745K104 9,497 556,340 SH   DFND 1 556,140 0 200
SUNRUN INC COM 86771W105 10,327 523,657 SH   DFND 1 523,462 0 195
SYNEOS HEALTH INC CL A 87166B102 21,766 373,669 SH   DFND 1 373,669 0 0
SYNEOS HEALTH INC CL A 87166B102 4,492 77,119 SH   OTR 2 77,119 0 0
SYNOPSYS INC COM 871607107 5,017 25,729 SH   DFND 1 25,729 0 0
SYSCO CORP COM 871829107 319 5,835 SH   DFND 1 5,835 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 67,791 1,194,135 SH   DFND 1 1,194,023 0 112
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 37,674 269,930 SH   DFND 1 268,758 0 1,172
TANDEM DIABETES CARE INC COM NEW 875372203 39,482 399,126 SH   DFND 1 399,126 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 6,008 60,740 SH   OTR 2 60,740 0 0
TARGA RES CORP COM 87612G101 16,647 829,439 SH   DFND 1 829,439 0 0
TAYLOR MORRISON HOME CORP COM 87724P106 706 36,606 SH   DFND 1 36,606 0 0
TC ENERGY CORP COM 87807B107 32,155 752,428 SH   DFND 1 752,428 0 0
TC PIPELINES LP UT COM LTD PRT 87233Q108 2,684 86,409 SH   DFND 1 86,409 0 0
TD AMERITRADE HLDG CORP COM 87236Y108 882 24,240 SH   DFND 1 24,240 0 0
TECH DATA CORP COM 878237106 816 5,627 SH   DFND 1 5,627 0 0
TELADOC HEALTH INC COM 87918A105 679,132 3,558,644 SH   DFND 1 3,343,929 0 214,715
TELADOC HEALTH INC COM 87918A105 22,004 115,303 SH   OTR 2 115,303 0 0
TELEFLEX INCORPORATED COM 879369106 51,812 142,348 SH   DFND 1 141,879 0 469
TERADYNE INC COM 880770102 3,220 38,101 SH   DFND 1 38,101 0 0
TESLA INC COM 88160R101 4,091,330 3,788,935 SH   DFND 1 3,624,865 0 164,070
TESLA INC COM 88160R101 86,176 79,807 SH   OTR 2 79,807 0 0
TEXAS INSTRS INC COM 882508104 135,598 1,067,951 SH   DFND 1 1,067,951 0 0
TFI INTL INC COM 87241L109 15,956 450,097 SH   DFND 1 450,097 0 0
TFI INTL INC COM 87241L109 2,627 74,113 SH   OTR 2 74,113 0 0
THE TRADE DESK INC COM CL A 88339J105 994,044 2,445,374 SH   DFND 1 2,298,696 0 146,678
THE TRADE DESK INC COM CL A 88339J105 27,502 67,655 SH   OTR 2 67,655 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 442 1,221 SH   DFND 1 1,221 0 0
THERMON GROUP HLDGS INC COM 88362T103 2,940 201,767 SH   DFND 1 201,767 0 0
THERMON GROUP HLDGS INC COM 88362T103 1,073 73,677 SH   OTR 2 73,677 0 0
TJX COS INC NEW COM 872540109 438 8,655 SH   DFND 1 8,655 0 0
TOLL BROTHERS INC COM 889478103 1,214 37,243 SH   DFND 1 37,243 0 0
TOTAL S.A. SPONSORED ADS 89151E109 25,859 672,355 SH   DFND 1 672,233 0 122
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 30,422 1,593,563 SH   DFND 1 1,593,563 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 5,859 306,937 SH   OTR 2 306,937 0 0
TPI COMPOSITES INC COM 87266J104 3,939 168,558 SH   DFND 1 168,495 0 63
TRANE TECHNOLOGIES PLC SHS G8994E103 31,210 350,757 SH   DFND 1 349,292 0 1,465
TRANSLATE BIO INC COM 89374L104 452 25,216 SH   DFND 1 25,216 0 0
TREX CO INC COM 89531P105 16,304 125,353 SH   DFND 1 125,353 0 0
TREX CO INC COM 89531P105 5,453 41,922 SH   OTR 2 41,922 0 0
TRI POINTE GROUP INC COM 87265H109 1,238 84,260 SH   DFND 1 84,260 0 0
TRINITY INDS INC COM 896522109 15,887 746,210 SH   DFND 1 746,210 0 0
TRINITY INDS INC COM 896522109 4,601 216,102 SH   OTR 2 216,102 0 0
TRUIST FINL CORP COM 89832Q109 104,132 2,773,166 SH   DFND 1 2,773,166 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 39,014 604,020 SH   DFND 1 604,020 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,969 30,484 SH   OTR 2 30,484 0 0
TWILIO INC CL A 90138F102 1,085,578 4,947,486 SH   DFND 1 4,656,979 0 290,507
TWILIO INC CL A 90138F102 28,041 127,798 SH   OTR 2 127,798 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,387,251 44,634,860 SH   DFND 1 42,926,293 0 1,708,567
UBER TECHNOLOGIES INC COM 90353T100 15,624 502,696 SH   OTR 2 502,696 0 0
UBIQUITI INC COM 90353W103 1,332 7,633 SH   DFND 1 7,633 0 0
UFP INDUSTRIES INC COM 90278Q108 505 10,194 SH   DFND 1 10,194 0 0
UNION PAC CORP COM 907818108 793,724 4,694,648 SH   DFND 1 4,511,292 0 183,356
UNION PAC CORP COM 907818108 8,567 50,673 SH   OTR 2 50,673 0 0
UNIQURE NV SHS N90064101 6,562 145,621 SH   DFND 1 145,621 0 0
UNITED CMNTY BKS BLAIRSVLE G COM 90984P303 648 32,212 SH   DFND 1 32,212 0 0
UNITED RENTALS INC COM 911363109 63,059 423,101 SH   DFND 1 423,101 0 0
UNITEDHEALTH GROUP INC COM 91324P102 108,719 368,600 SH   DFND 1 368,600 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 9,192 61,438 SH   DFND 1 61,438 0 0
VAIL RESORTS INC COM 91879Q109 12,630 69,339 SH   DFND 1 69,339 0 0
VALERO ENERGY CORP COM 91913Y100 5,279 89,741 SH   DFND 1 89,706 0 35
VANGUARD INDEX FDS GROWTH ETF 922908736 247 1,224 SH   DFND 1 1,224 0 0
VARONIS SYS INC COM 922280102 43,359 490,044 SH   DFND 1 490,044 0 0
VARONIS SYS INC COM 922280102 9,019 101,937 SH   OTR 2 101,937 0 0
VEEVA SYS INC CL A COM 922475108 1,341 5,719 SH   DFND 1 5,719 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 121,382 2,201,741 SH   DFND 1 2,201,741 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,269,634 4,373,373 SH   DFND 1 4,220,991 0 152,382
VERTEX PHARMACEUTICALS INC COM 92532F100 13,095 45,108 SH   OTR 2 45,108 0 0
VISA INC COM CL A 92826C839 2,435,565 12,608,405 SH   DFND 1 12,086,272 0 522,133
VISA INC COM CL A 92826C839 25,385 131,412 SH   OTR 2 131,412 0 0
VISHAY INTERTECHNOLOGY INC COM 928298108 705 46,164 SH   DFND 1 46,164 0 0
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 15,190 952,951 SH   DFND 1 952,951 0 0
VROOM INC COM 92918V109 27,873 534,583 SH   DFND 1 534,583 0 0
VROOM INC COM 92918V109 4,677 89,703 SH   OTR 2 89,703 0 0
WABTEC COM 929740108 4,723 82,036 SH   DFND 1 82,036 0 0
WALMART INC COM 931142103 149,507 1,248,182 SH   DFND 1 1,248,182 0 0
WASTE CONNECTIONS INC COM 94106B101 8,593 91,624 SH   DFND 1 91,624 0 0
WASTE MGMT INC DEL COM 94106L109 5,580 52,683 SH   DFND 1 52,683 0 0
WELLS FARGO CO NEW COM 949746101 8,166 318,977 SH   DFND 1 318,977 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 1,466 6,453 SH   DFND 1 6,453 0 0
WESTERN DIGITAL CORP. COM 958102105 775 17,544 SH   DFND 1 17,544 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 6,486 147,249 SH   DFND 1 147,193 0 56
WILLIAMS COS INC COM 969457100 129,832 6,826,068 SH   DFND 1 6,826,068 0 0
WINGSTOP INC COM 974155103 29,689 213,642 SH   DFND 1 213,642 0 0
WINGSTOP INC COM 974155103 9,523 68,523 SH   OTR 2 68,523 0 0
WINNEBAGO INDS INC COM 974637100 1,036 15,557 SH   DFND 1 15,557 0 0
WINTRUST FINL CORP COM 97650W108 27,086 620,949 SH   DFND 1 620,949 0 0
WINTRUST FINL CORP COM 97650W108 4,645 106,491 SH   OTR 2 106,491 0 0
WORKDAY INC CL A 98138H101 785,870 4,194,437 SH   DFND 1 3,927,987 0 266,450
WORKDAY INC CL A 98138H101 10,665 56,924 SH   OTR 2 56,924 0 0
WPX ENERGY INC COM 98212B103 49,732 7,794,884 SH   DFND 1 7,794,215 0 669
WPX ENERGY INC COM 98212B103 4,665 731,224 SH   OTR 2 731,224 0 0
WSFS FINL CORP COM 929328102 7,438 259,180 SH   DFND 1 259,180 0 0
WSFS FINL CORP COM 929328102 1,108 38,597 SH   OTR 2 38,597 0 0
XCEL ENERGY INC COM 98389B100 53,874 861,984 SH   DFND 1 861,984 0 0
ZAI LAB LTD ADR 98887Q104 20,872 254,128 SH   DFND 1 254,128 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 88,011 737,356 SH   DFND 1 737,356 0 0
ZOETIS INC CL A 98978V103 200,663 1,464,263 SH   DFND 1 1,391,800 0 72,463
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 1,333 5,259 SH   DFND 1 5,259 0 0
ZUMIEZ INC COM 989817101 203 7,414 SH   DFND 1 7,414 0 0