The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 15,633 370,000 SH   OTR   370,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 8,830 416,495 SH   OTR   416,495 0 0
AGENUS INC COM NEW 00847G705 9,800 4,000,000 SH   OTR   4,000,000 0 0
ALLAKOS INC COM 01671P100 30,031 675,000 SH   OTR   675,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 9,000 2,250,000 SH   OTR   2,250,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 21,483 2,325,000 SH   OTR   2,325,000 0 0
ANAPTYSBIO INC COM 032724106 18,369 1,300,000 SH   OTR   1,300,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 42,818 3,084,883 SH   OTR   3,084,883 0 0
ARGENX SE SPONSORED ADR 04016X101 26,346 200,000 SH   OTR   200,000 0 0
ARTARA THERAPEUTICS INC COM 04300J107 4,590 199,567 SH   OTR   199,567 0 0
ATRECA INC CL A COM 04965G109 28,691 1,733,583 SH   OTR   1,733,583 0 0
AXSOME THERAPEUTICS INC COM 05464T104 8,825 150,000 SH   OTR   150,000 0 0
BARCLAYS BK PLC SHRT TRM ETN 48 06746P621 3,469 75,000 SH   OTR   75,000 0 0
BARCLAYS BK PLC PUT 06746P951 13,875 300,000 SH Put OTR   300,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 113,877 925,000 SH   OTR   925,000 0 0
BELLEROPHON THERAPEUTICS INC COM 078771300 1,083 98,809 SH   OTR   98,809 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 17,715 1,775,000 SH   OTR   1,775,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 21,125 250,000 SH   OTR   250,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 50,271 2,014,858 SH   OTR   2,014,858 0 0
CABALETTA BIO INC COM 12674W109 11,434 1,566,361 SH   OTR   1,566,361 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 1,226 920,000 SH   OTR   920,000 0 0
COMPUGEN LTD ORD M25722105 17,305 2,383,673 SH   OTR   2,383,673 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,960 2,000,000 SH   OTR   2,000,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 27,576 7,034,598 SH   OTR   7,034,598 0 0
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460E539 17,600 1,250,000 SH   OTR   1,250,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 30,742 975,000 SH   OTR   975,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 12,773 250,000 SH   OTR   250,000 0 0
GOSSAMER BIO INC COM 38341P102 22,178 2,185,000 SH   OTR   2,185,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 3,149 764,252 SH   OTR   764,252 0 0
IMMUNOMEDICS INC COM 452907108 113,906 8,450,000 SH   OTR   8,450,000 0 0
KADMON HLDGS INC COM 48283N106 26,003 6,205,882 SH   OTR   6,205,882 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 4,498 290,577 SH   OTR   290,577 0 0
KODIAK SCIENCES INC COM 50015M109 7,155 150,000 SH   OTR   150,000 0 0
KURA ONCOLOGY INC COM 50127T109 8,406 844,789 SH   OTR   844,789 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3,741 890,700 SH   OTR   890,700 0 0
LIFESCI ACQUISITION CORP UNIT 03/31/2025 53228P208 3,000 300,000 SH   OTR   300,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 9,744 4,800,000 SH   OTR   4,800,000 0 0
MATINAS BIOPHARMA HLDGS INC COM 576810105 6,889 11,478,634 SH   OTR   11,478,634 0 0
MEI PHARMA INC COM NEW 55279B202 4,690 2,913,091 SH   OTR   2,913,091 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 2,561 2,450,543 SH   OTR   2,450,543 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 2,028 1,102,194 SH   OTR   1,102,194 0 0
MIRATI THERAPEUTICS INC COM 60468T105 135,719 1,765,560 SH   OTR   1,765,560 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 4,438 317,000 SH   OTR   317,000 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 11,485 1,009,255 SH   OTR   1,009,255 0 0
ODONATE THERAPEUTICS INC COM 676079106 92,863 3,363,377 SH   OTR   3,363,377 0 0
PASSAGE BIO INC COM 702712100 29,662 1,883,315 SH   OTR   1,883,315 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 13,691 1,123,105 SH   OTR   1,123,105 0 0
REGENERON PHARMACEUTICALS COM 75886F107 65,919 135,000 SH   OTR   135,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 10,233 300,000 SH   OTR   300,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 66,820 3,049,764 SH   OTR   3,049,764 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 20,451 1,466,051 SH   OTR   1,466,051 0 0
SAGE THERAPEUTICS INC COM 78667J108 44,014 1,532,510 SH   OTR   1,532,510 0 0
SEATTLE GENETICS INC COM 812578102 46,152 400,000 SH   OTR   400,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 7,915 3,284,072 SH   OTR   3,284,072 0 0
SOLID BIOSCIENCES INC COM 83422E105 3,661 1,531,872 SH   OTR   1,531,872 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 56,049 2,075,905 SH   OTR   2,075,905 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 7,962 725,782 SH   OTR   725,782 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 16,463 4,075,000 SH   OTR   4,075,000 0 0
UNIQURE NV SHS N90064101 36,318 765,400 SH   OTR   765,400 0 0
XENON PHARMACEUTICALS INC COM 98420N105 6,804 600,000 SH   OTR   600,000 0 0
ZOGENIX INC COM NEW 98978L204 4,328 175,000 SH   OTR   175,000 0 0
ZYMEWORKS INC COM 98985W102 887 25,000 SH   OTR   25,000 0 0