The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 55,175 724,174 SH   DFND   0 724,174 0
ACCELERON PHARMA INC COM 00434H108 5,518 61,400 SH   DFND   0 61,400 0
ACORDA THERAPEUTICS INC COM 00484M106 1,423 1,526,174 SH   DFND   0 1,526,174 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 1,721 2,000,000 PRN   DFND   0 2,000,000 0
AERIE PHARMACEUTICALS INC COM 00771V108 34,132 2,528,276 SH   DFND   0 2,528,276 0
ALEXION PHARMACEUTICALS INC COM 015351109 61,618 686,249 SH   DFND   0 686,249 0
ALLENA PHARMACEUTICALS INC COM 018119107 274 284,285 SH   DFND 1 0 284,285 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 13,630 70,083 SH   DFND   0 70,083 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,904 81,804 SH   DFND   0 81,804 0
AMAZON COM INC COM 023135106 10,415 5,342 SH   DFND   0 5,342 0
AMERISOURCEBERGEN CORP COM 03073E105 29,978 338,732 SH   DFND   0 338,732 0
ANTHEM INC COM 036752103 50,840 223,925 SH   DFND   0 223,925 0
ARCUS BIOSCIENCES INC COM 03969F109 11,236 809,511 SH   DFND   0 809,511 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 31,467 749,217 SH   DFND   0 749,217 0
BAXTER INTL INC COM 071813109 25,139 309,635 SH   DFND   0 309,635 0
BECTON DICKINSON & CO COM 075887109 34,730 151,150 SH   DFND   0 151,150 0
BIOGEN INC COM 09062X103 25,631 81,013 SH   DFND   0 81,013 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 33,767 399,605 SH   DFND   0 399,605 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 43,421 41,600,000 PRN   DFND   0 41,600,000 0
CARDINAL HEALTH INC COM 14149Y108 42,117 878,531 SH   DFND   0 878,531 0
CENTENE CORP DEL COM 15135B101 18,265 307,441 SH   DFND   0 307,441 0
CIGNA CORP NEW COM 125523100 34,495 194,690 SH   DFND   0 194,690 0
COHERUS BIOSCIENCES INC COM 19249H103 7,689 474,055 SH   DFND   0 474,055 0
CONSTELLATION PHARMCETICLS I COM 210373106 9,929 315,894 SH   DFND   0 315,894 0
COUPA SOFTWARE INC COM 22266L106 2,922 20,909 SH   DFND   0 20,909 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 8,495 206,336 SH   DFND   0 206,336 0
DEERE & CO COM 244199105 5,555 40,208 SH   DFND   0 40,208 0
EDWARDS LIFESCIENCES CORP COM 28176E108 22,331 118,392 SH   DFND   0 118,392 0
FLUIDIGM CORP DEL COM 34385P108 6,790 2,673,090 SH   DFND   0 2,673,090 0
GILEAD SCIENCES INC COM 375558103 41,368 553,339 SH   DFND   0 553,339 0
HALOZYME THERAPEUTICS INC COM 40637H109 11,131 618,726 SH   DFND   0 618,726 0
HCA HEALTHCARE INC COM 40412C101 16,699 185,849 SH   DFND   0 185,849 0
HERON THERAPEUTICS INC COM 427746102 29,138 2,481,917 SH   DFND   0 2,481,917 0
HUMANA INC COM 444859102 32,353 103,030 SH   DFND   0 103,030 0
ICON PLC SHS G4705A100 12,573 92,446 SH   DFND   0 92,446 0
ICU MED INC COM 44930G107 40,826 202,339 SH   DFND   0 202,339 0
IGM BIOSCIENCES INC COM 449585108 9,158 163,105 SH   DFND   0 163,105 0
IMMUNOMEDICS INC COM 452907108 6,035 447,700 SH Call DFND   0 447,700 0
IMMUNOMEDICS INC COM 452907108 14,343 1,064,041 SH   DFND   0 1,064,041 0
INSMED INC COM PAR $.01 457669307 3,667 228,781 SH   DFND   0 228,781 0
IQVIA HLDGS INC COM 46266C105 16,956 157,201 SH   DFND   0 157,201 0
IRHYTHM TECHNOLOGIES INC COM 450056106 18,988 233,409 SH   DFND   0 233,409 0
JOHNSON & JOHNSON COM 478160104 21,817 166,375 SH   DFND   0 166,375 0
KARUNA THERAPEUTICS INC COM 48576A100 35,965 499,510 SH   DFND   0 499,510 0
MCKESSON CORP COM 58155Q103 46,523 343,950 SH   DFND   0 343,950 0
MICROSOFT CORP COM 594918104 15,010 95,177 SH   DFND   0 95,177 0
MOLINA HEALTHCARE INC COM 60855R100 17,386 124,444 SH   DFND   0 124,444 0
MORPHOSYS AG SPONSORED ADS D55040105 9,270 102,941 SH   DFND   0 102,941 0
MYOKARDIA INC COM 62857M105 1,669 35,592 SH   DFND   0 35,592 0
NEXTERA ENERGY INC COM 65339F101 3,205 13,320 SH   DFND   0 13,320 0
NVIDIA CORP COM 67066G104 16,302 61,842 SH   DFND   0 61,842 0
PENUMBRA INC COM 70975L107 19,068 118,190 SH   DFND   0 118,190 0
PFIZER INC COM 717081103 38,537 1,180,658 SH   DFND   0 1,180,658 0
PPD INC COM 69355F102 8,509 477,743 SH   DFND   0 477,743 0
REATA PHARMACEUTICALS INC CL A 75615P103 14,126 97,864 SH   DFND   0 97,864 0
SAGE THERAPEUTICS INC COM 78667J108 12,536 436,477 SH   DFND   0 436,477 0
SHOPIFY INC CL A 82509L107 3,942 9,454 SH   DFND   0 9,454 0
UNITEDHEALTH GROUP INC COM 91324P102 26,116 104,722 SH   DFND   0 104,722 0
VERTEX PHARMACEUTICALS INC COM 92532F100 22,720 95,482 SH   DFND   0 95,482 0
XILINX INC COM 983919101 9,717 124,677 SH   DFND   0 124,677 0
ZAI LAB LTD ADR 98887Q104 4,344 84,387 SH   DFND   0 84,387 0