The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics, Inc. Common 00461U105 1,713 1,647,214 SH   SOLE   1,647,214 0 0
Aduro Biotech Inc Common 00739L101 14,025 5,118,560 SH   SOLE   5,118,560 0 0
Akero Therapeutics Inc Common 00973Y108 17,135 808,247 SH   SOLE   808,247 0 0
Amyris, Inc Common 03236M200 16,620 6,492,247 SH   SOLE   6,492,247 0 0
Arcutis Biotherapeutics Inc Common 03969K108 50,259 1,686,527 SH   SOLE   1,686,527 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 22,115 768,674 SH   SOLE   768,674 0 0
Ascendis Pharma A/S ADR 04351P101 225,574 2,003,147 SH   SOLE   2,003,147 0 0
Atricure Inc Common 04963C209 2,169 64,573 SH   SOLE   64,573 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 7,266 500,732 SH   SOLE   500,732 0 0
Avadel Pharmaceuticals PLC ADR 05337M104 28,389 3,575,424 SH   SOLE   3,575,424 0 0
Avrobio Inc Common 05455M100 11,168 717,753 SH   SOLE   717,753 0 0
Black Diamond Therapeutics Inc Common 09203E105 6,290 252,119 SH   SOLE   252,119 0 0
Chiasma Inc Common 16706W102 4,643 1,272,156 SH   SOLE   1,272,156 0 0
Codexis, Inc Common 192005106 16,672 1,493,903 SH   SOLE   1,493,903 0 0
Collegium Pharmaceutical Inc Common 19459J104 7,302 447,173 SH   SOLE   447,173 0 0
Constellation Pharmaceutical Common 210373106 4,410 140,298 SH   SOLE   140,298 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 48,816 3,320,801 SH   SOLE   3,320,801 0 0
Cymabay Therapeutics Inc Common 23257D103 1,595 1,077,467 SH   SOLE   1,077,467 0 0
DBV Technologies S.A. ADR 23306J101 1,058 269,995 SH   SOLE   269,995 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 12,181 1,791,257 SH   SOLE   1,791,257 0 0
Forty Seven Inc Common 34983P104 37,757 395,691 SH   SOLE   395,691 0 0
Galmed Pharmaceuticals Ltd SHS M47238106 2,976 860,103 SH   SOLE   860,103 0 0
Homology Medicines, Inc. Common 438083107 15,673 1,008,562 SH   SOLE   1,008,562 0 0
IGM Biosciences Inc Common 449585108 11,209 199,626 SH   SOLE   199,626 0 0
Kadmon Holdings Inc Common 48283N106 52,541 12,539,515 SH   SOLE   12,539,515 0 0
Kala Pharmaceuticals, Inc. Common 483119103 6,917 786,883 SH   SOLE   786,883 0 0
KalVista Pharmaceuticals Inc. Common 483497103 11,297 1,476,796 SH   SOLE   1,476,796 0 0
Karuna Therapeutics Inc Common 48576A100 16,106 223,692 SH   SOLE   223,692 0 0
Kiniksa Pharmaceuticals Common G5269C101 11,750 759,050 SH   SOLE   759,050 0 0
Matinas Biopharma Hldgs Inc Common 576810105 6,770 11,279,323 SH   SOLE   11,279,323 0 0
MEI Pharma Inc Common 55279B202 15,753 9,784,422 SH   SOLE   9,784,422 0 0
Menlo Therapeutics Inc. Common 586858102 10,301 3,843,824 SH   SOLE   3,843,824 0 0
Myokardia Inc Common 62857M105 15,640 333,621 SH   SOLE   333,621 0 0
Nabriva Therapeutics AG SHS G63637105 980 1,704,130 SH   SOLE   1,704,130 0 0
New Frontier Health Corp Common G6461G106 117,975 14,300,000 SH   SOLE   14,300,000 0 0
Orchard Therapeutics plc ADS 68570P101 12,253 1,627,225 SH   SOLE   1,627,225 0 0
Passage Bio Inc Common 702712100 35,116 2,229,587 SH   SOLE   2,229,587 0 0
Precision Biosciences Inc Common 74019P108 846 140,255 SH   SOLE   140,255 0 0
Revolution Medicines Inc Common 76155X100 4,371 199,518 SH   SOLE   199,518 0 0
Rocket Pharmaceuticals Inc Common 77313F106 12,006 860,648 SH   SOLE   860,648 0 0
Selecta Biosciences Inc Common 816212104 18,910 7,846,509 SH   SOLE   7,846,509 0 0
Sierra Oncology, Inc Common 82640U107 18,826 1,917,074 SH   SOLE   1,917,074 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Soleno Therapeutics, Inc. Common 834203200 4,811 2,021,377 SH   SOLE   2,021,377 0 0
Tricida, Inc. Common 89610F101 11,534 524,290 SH   SOLE   524,290 0 0
Trillium Therapeutics Inc Common 89620X506 8,300 2,054,468 SH   SOLE   2,054,468 0 0
Uniqure NV Common N90064101 1,088 22,932 SH   SOLE   22,932 0 0
Verastem Inc Common 92337C104 21,488 8,139,535 SH   SOLE   8,139,535 0 0
Verona Pharma PLC ADS 925050106 6,151 1,492,951 SH   SOLE   1,492,951 0 0
Xenon Pharmaceuticals Inc Common 98420N105 4,497 396,589 SH   SOLE   396,589 0 0
Zai Lab Limited ADR 98887Q104 11,434 222,107 SH   SOLE   222,107 0 0
Zogenix Inc Common 98978L204 21,978 888,724 SH   SOLE   888,724 0 0
Zymeworks Inc Common 98985W102 39,061 1,101,236 SH   SOLE   1,101,236 0 0