The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCELERON PHARMA INC | COM | 00434H108 | 74,143 | 825,000 | SH | DFND | 1 | 825,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 29,827 | 12,174,486 | SH | DFND | 1 | 12,174,486 | 0 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 13,622 | 642,539 | SH | DFND | 1 | 642,539 | 0 | 0 | |
| ALLAKOS INC | COM | 01671P100 | 8,898 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 3,600 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 15,655 | 1,107,900 | SH | DFND | 1 | 1,107,900 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 60,709 | 2,266,108 | SH | DFND | 1 | 2,266,108 | 0 | 0 | |
| ARCTURUS THERAPEUTICS HLDG I | COM | 03969T109 | 3,561 | 262,037 | SH | DFND | 1 | 262,037 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 4,200 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 10,538 | 80,000 | SH | DFND | 1 | 80,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 28,153 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 39,414 | 350,000 | SH | Call | DFND | 1 | 350,000 | 0 | 0 |
| ATRECA INC | CL A COM | 04965G109 | 5,398 | 326,139 | SH | DFND | 1 | 326,139 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 2,875 | 479,988 | SH | DFND | 1 | 479,988 | 0 | 0 | |
| AVROBIO INC | COM | 05455M100 | 4,942 | 317,579 | SH | DFND | 1 | 317,579 | 0 | 0 | |
| AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 20,328 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 29,415 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| BEAM THERAPEUTICS INC | COM | 07373V105 | 14,336 | 796,429 | SH | DFND | 1 | 796,429 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 29,795 | 875,551 | SH | DFND | 1 | 875,551 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 26,316 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 85,550 | 2,950,000 | SH | DFND | 1 | 2,950,000 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 15,373 | 2,105,846 | SH | DFND | 1 | 2,105,846 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 81,365 | 2,025,000 | SH | DFND | 1 | 2,025,000 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 25,113 | 625,000 | SH | Call | DFND | 1 | 625,000 | 0 | 0 |
| CONSTELLATION PHARMACEUTICALS I | COM | 210373106 | 64,118 | 2,040,021 | SH | DFND | 1 | 2,040,021 | 0 | 0 | |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 26,735 | 630,400 | SH | DFND | 1 | 630,400 | 0 | 0 | |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 14,410 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 53,889 | 1,100,000 | SH | DFND | 1 | 1,100,000 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 5,543 | 815,127 | SH | DFND | 1 | 815,127 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 1,666 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 19,681 | 98,603 | SH | DFND | 1 | 98,603 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 2,014 | 198,382 | SH | DFND | 1 | 198,382 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 7,527 | 649,993 | SH | DFND | 1 | 649,993 | 0 | 0 | |
| HOMOLOGY MEDICINES INC | COM | 438083107 | 9,324 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| IGM BIOSCIENCES INC | COM | 449585108 | 23,926 | 426,104 | SH | DFND | 1 | 426,104 | 0 | 0 | |
| IMMUNOVANT INC | UNIT 12/18/2024 | 45258J201 | 19,396 | 1,078,380 | SH | DFND | 1 | 1,078,380 | 0 | 0 | |
| INSMED INC | COM PAR $.01 | 457669307 | 5,807 | 362,273 | SH | DFND | 1 | 362,273 | 0 | 0 | |
| INSPIRE MED SYS INC | COM | 457730109 | 9,042 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 7,960 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| MERUS N V | COM | N5749R100 | 7,260 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 3,660 | 607,903 | SH | DFND | 1 | 607,903 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 65,340 | 850,000 | SH | DFND | 1 | 850,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 38,435 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| MYOKARDIA INC | COM | 62857M105 | 32,816 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| MYOVANT SCIENCES LTD | COM | G637AM102 | 19,630 | 2,600,000 | SH | DFND | 1 | 2,600,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 2,678 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 2,164 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| NEXTCURE INC | COM | 65343E108 | 27,558 | 743,400 | SH | DFND | 1 | 743,400 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 33,742 | 2,523,700 | SH | DFND | 1 | 2,523,700 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 1,933 | 256,649 | SH | DFND | 1 | 256,649 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 65 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 2,090 | 346,524 | SH | DFND | 1 | 346,524 | 0 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 124,698 | 2,100,000 | SH | DFND | 1 | 2,100,000 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 12,488 | 3,161,500 | SH | DFND | 1 | 3,161,500 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 70,323 | 487,206 | SH | DFND | 1 | 487,206 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 36,085 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 60,627 | 2,767,078 | SH | DFND | 1 | 2,767,078 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 21,881 | 1,568,550 | SH | DFND | 1 | 1,568,550 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 14,673 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 17,396 | 808,382 | SH | DFND | 1 | 808,382 | 0 | 0 | |
| SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 9,200 | 5,000,000 | SH | DFND | 1 | 5,000,000 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 257,750 | 1,000,000 | SH | Put | DFND | 1 | 1,000,000 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 39,154 | 1,709,765 | SH | DFND | 1 | 1,709,765 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 2,311 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| TRICIDA INC | COM | 89610F101 | 19,315 | 877,975 | SH | DFND | 1 | 877,975 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 136,517 | 3,056,797 | SH | DFND | 1 | 3,056,797 | 0 | 0 | |
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 21,013 | 687,149 | SH | DFND | 1 | 687,149 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 11,863 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| VIELA BIO INC | COM | 926613100 | 66,975 | 1,762,500 | SH | DFND | 1 | 1,762,500 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 3,416 | 341,618 | SH | DFND | 1 | 341,618 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 45,210 | 1,732,200 | SH | DFND | 1 | 1,732,200 | 0 | 0 | |
| ZAI LAB LTD | ADR | 98887Q104 | 14,882 | 289,092 | SH | DFND | 1 | 289,092 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 24,829 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |