The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 1,281 674,300 SH   SOLE 674,300 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 3,961 293,440 SH   SOLE 293,440 0 0
AFFIMED NV COM N01045108 1,791 1,133,401 SH   SOLE 1,133,401 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 6,470 853,538 SH   SOLE 853,538 0 0
ALECTOR INC COM 014442107 3,740 155,000 SH   SOLE 155,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,448 54,054 SH   SOLE 54,054 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 3,808 1,160,878 SH   SOLE 1,160,878 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 715 52,586 SH   SOLE 52,586 0 0
ARCUS BIOSCIENCES INC COM 03969F109 386 27,798 SH   SOLE 27,798 0 0
ARDELYX INC COM 039697107 1,051 184,850 SH   SOLE 184,850 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 7,545 179,642 SH   SOLE 179,642 0 0
ARGENX SE SPONSORED ADR 04016X101 589 4,471 SH   SOLE 4,471 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,799 33,737 SH   SOLE 33,737 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 88 86,082 SH   SOLE 86,082 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 528 35,573 SH   SOLE 35,573 0 0
ATRICURE INC COM 04963C209 8,052 239,729 SH   SOLE 239,729 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,317 219,800 SH   SOLE 219,800 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 2,493 1,021,566 SH   SOLE 1,021,566 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 958 479,051 SH   SOLE 479,051 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 3,083 90,600 SH   SOLE 90,600 0 0
BIOTELEMETRY INC COM 090672106 2,330 60,500 SH   SOLE 60,500 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 103 4,614 SH   SOLE 4,614 0 0
BLUEBIRD BIO INC COM 09609G100 1,172 25,500 SH   SOLE 25,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 13,339 228,089 SH   SOLE 228,089 0 0
CARA THERAPEUTICS INC COM 140755109 4,901 371,033 SH   SOLE 371,033 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 1,803 51,200 SH   SOLE 51,200 0 0
COMPUGEN LTD ORD M25722105 4,356 600,000 SH   SOLE 600,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 3,916 747,300 SH   SOLE 747,300 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 767 100,000 SH   SOLE 100,000 0 0
DEXCOM INC COM 252131107 8,977 33,338 SH   SOLE 33,338 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 687 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,714 147,714 SH   SOLE 147,714 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 375 191,494 SH   SOLE 191,494 0 0
EPIZYME INC COM 29428V104 1,643 105,900 SH   SOLE 105,900 0 0
EXICURE INC COM 30205M101 407 275,000 SH   SOLE 275,000 0 0
FATE THERAPEUTICS INC COM 31189P102 10,439 470,000 SH   SOLE 470,000 0 0
GALAPAGOS NV SPON ADR 36315X101 9,086 46,375 SH   SOLE 46,375 0 0
GAMIDA CELL LTD SHS M47364100 449 148,781 SH   SOLE 148,781 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 933 542,564 SH   SOLE 542,564 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 291 50,000 SH   SOLE 50,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 1,708 147,468 SH   SOLE 147,468 0 0
INOGEN INC COM 45780L104 1,188 23,000 SH   SOLE 23,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 7,854 72,900 SH   SOLE 72,900 0 0
JOHNSON AND JOHNSON COM 478160104 1,233 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 2,332 556,564 SH   SOLE 556,564 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,797 234,952 SH   SOLE 234,952 0 0
KARUNA THERAPEUTICS INC COM 48576A100 449 6,231 SH   SOLE 6,231 0 0
KURA ONCOLOGY INC COM 50127T109 3,060 307,541 SH   SOLE 307,541 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 79 95,000 SH   SOLE 95,000 0 0
LUMINEX CORP COM 55027E102 5,619 204,091 SH   SOLE 204,091 0 0
MACROGENICS INC COM 556099109 873 150,000 SH   SOLE 150,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 908 13,600 SH   SOLE 13,600 0 0
MASIMO CORPORATION COM 574795100 531 3,000 SH   SOLE 3,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,341 401,619 SH   SOLE 401,619 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,236 42,102 SH   SOLE 42,102 0 0
MORPHIC HOLDING INC COM 61775R105 543 37,000 SH   SOLE 37,000 0 0
NATUS MEDICAL INC COM 639050103 992 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 6,942 80,208 SH   SOLE 80,208 0 0
NEURONETICS INC COM 64131A105 937 495,772 SH   SOLE 495,772 0 0
NEXTCURE INC COM 65343E108 741 20,000 SH   SOLE 20,000 0 0
OTONOMY INC COM 68906L105 924 469,135 SH   SOLE 469,135 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 1,061 320,542 SH   SOLE 320,542 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 914 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 6,793 1,237,400 SH   SOLE 1,237,400 0 0
RADIUS HEALTH INC COM NEW 750469207 286 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 2,828 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 246 157,700 SH   SOLE 157,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,748 165,306 SH   SOLE 165,306 0 0
SPERO THERAPEUTICS INC COM 84833T103 389 48,103 SH   SOLE 48,103 0 0
STEREOTAXIS INC COM NEW 85916J409 41,315 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 408 40,000 SH   SOLE 40,000 0 0
SYNLOGIC INC COM 87166L100 861 500,731 SH   SOLE 500,731 0 0
TCR2 THERAPEUTICS INC COM 87808K106 610 78,786 SH   SOLE 78,786 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 2,095 46,908 SH   SOLE 46,908 0 0
UROGEN PHARMA LTD COM M96088105 42 2,369 SH   SOLE 2,369 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,110 450,900 SH   SOLE 450,900 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,930 346,535 SH   SOLE 346,535 0 0
ZAFGEN INC COM 98885E103 235 305,500 SH   SOLE 305,500 0 0
ZOGENIX INC COM NEW 98978L204 3,543 143,249 SH   SOLE 143,249 0 0
ZYMEWORKS INC COM 98985W102 1,135 32,000 SH   SOLE 32,000 0 0