The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 10,138 750,974 SH   SOLE   750,974 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 25,719 3,393,039 SH   SOLE   3,393,039 0 0
AMICUS THERAPEUTICS INC COM 03152W109 21,437 2,320,026 SH   SOLE   2,320,026 0 0
APPLE INC COM 037833100 103,650 407,606 SH   SOLE   407,606 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,841 54,100 SH   SOLE   54,100 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 13,700 234,267 SH   SOLE   234,267 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 60,395 2,047,305 SH   SOLE   2,047,305 0 0
CABLE ONE INC COM 12685J105 122,635 74,595 SH   SOLE   74,595 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 5,292 168,381 SH   SOLE   168,381 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 6,177 2,927,560 SH   SOLE   2,927,560 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 2,417 164,453 SH   SOLE   164,453 0 0
ENTASIS THERAPEUTICS HLDGS I COM 293614103 5,760 2,181,843 SH   SOLE   2,181,843 0 0
FLEXION THERAPEUTICS INC COM 33938JAB2 5,063 643,370 SH   SOLE   643,370 0 0
GALERA THERAPEUTICS INC COM 36338D108 32,386 3,409,021 SH   SOLE   3,409,021 0 0
INOGEN INC COM 45780L104 183,358 3,549,321 SH   SOLE   3,549,321 0 0
INSPIRE MED SYS INC COM 457730109 9,321 154,622 SH   SOLE   154,622 0 0
INTERSECT ENT INC COM 46071F103 4,392 370,595 SH   SOLE   370,595 0 0
MILESTONE PHARMACEUTICALS INC COM 59935V107 3,828 2,080,585 SH   SOLE   2,080,585 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 34,232 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 38,835 2,645,446 SH   SOLE   2,645,446 0 0
MYOKARDIA INC COM 62857M105 7,117 151,816 SH   SOLE   151,816 0 0
NEURONETICS INC COM 64131A105 1,706 902,872 SH   SOLE   902,872 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 4,927 697,899 SH   SOLE   697,899 0 0
SEASPINE HLDGS CORP COM 81255T108 14,015 1,715,431 SH   SOLE   1,715,431 0 0
SI BONE INC COM 825704109 11,608 971,390 SH   SOLE   971,390 0 0
SILK ROAD MEDICAL INC COM 82710M100 5,857 186,042 SH   SOLE   186,042 0 0
SPERO THERAPEUTICS INC COM 84833T103 7,523 931,099 SH   SOLE   931,099 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 746,440 5,790,400 SH   SOLE   5,790,400 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,052 740,740 SH   SOLE   740,740 0 0
ZOGENIX INC COM NEW 98978L204 5,519 223,184 SH   SOLE   223,184 0 0