The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 4,297 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
21VIANET GROUP INC SPONSORED ADS 90138A103 13,860 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AC IMMUNE SA SHS H00263105 6,910 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 4,998 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ACCELERON PHARMA INC COM 00434H108 134,805 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 5,556 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ADURO BIOTECH INC COM 00739L101 2,740 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 5,862 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,864 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AGENUS INC COM NEW 00847G705 6,125 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 14,192 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 3,222 425,000 SH   DFND 1,2,3,4,5,6 425,000 0 0
ALBIREO PHARMA INC COM 01345P106 9,628 588,125 SH   DFND 1,2,3,4,5,6 588,125 0 0
ALECTOR INC COM 014442107 6,033 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 77,792 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 77,792 400,000 SH Call DFND 1,2,3,4,5,6 400,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 119,735 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 6,095 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 46,200 5,000,000 SH   DFND 1,2,3,4,5,6 5,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 9,240 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
APTINYX INC COM 03836N103 3,600 1,666,666 SH   DFND 1,2,3,4,5,6 1,666,666 0 0
ARAVIVE INC COM 03890D108 8,352 1,450,000 SH   DFND 1,2,3,4,5,6 1,450,000 0 0
ARGENX SE SPONSORED ADR 04016X101 62,572 475,000 SH   DFND 1,2,3,4,5,6 475,000 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 17,262 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 11,261 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 21,275 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 10,883 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 2,995 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AVANTOR INC COM 05352A100 56,205 4,500,000 SH   DFND 1,2,3,4,5,6 4,500,000 0 0
AXCELLA HEALTH INC COM 05454B105 2,052 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BK OF AMERICA CORP COM 060505104 42,460 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 80,022 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 16,900 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 130,123 2,228,130 SH   DFND 1,2,3,4 2,228,130 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 42,328 1,696,517 SH   DFND 1,2,3,4,5,6 1,696,517 0 0
BLUEBIRD BIO INC COM 09609G100 4,596 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 23,392 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 11,696 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 15,950 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 6,360 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,180 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
CURIS INC COM NEW 231269200 1,056 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 4,904 1,850,531 SH   DFND 1,2,3,4,5,6 1,850,531 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 29 11,053 SH   DFND 1,2,3,4 11,053 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 32,936 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 8,755 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
EPIZYME INC COM 29428V104 35,673 2,300,000 SH   DFND 1,2,3,4,5,6 2,300,000 0 0
EPIZYME INC COM 29428V104 3,878 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
FATE THERAPEUTICS INC COM 31189P102 46,641 2,100,000 SH   DFND 1,2,3,4,5,6 2,100,000 0 0
FIBROGEN INC COM 31572Q808 20,850 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
GOSSAMER BIO INC COM 38341P102 18,361 1,808,968 SH   DFND 1,2,3,4,5,6 1,808,968 0 0
HARPOON THERAPEUTICS INC COM 41358P106 13,896 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
HOOKIPA PHARMA INC COM 43906K100 6,569 796,259 SH   DFND 1,2,3,4,5,6 796,259 0 0
I MAB SPONSORED ADS 44975P103 4,550 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
IMMUNIC INC COM 4525EP101 3,812 630,019 SH   DFND 1,2,3,4,5,6 630,019 0 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 35,406 600,000 SH Call DFND 1,2,3,4,5,6 600,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 22,451 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,115 110,532 SH   DFND 1,2,3,4 110,532 0 0
KALEIDO BIOSCIENCES INC COM 483347100 3,078 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KRYSTAL BIOTECH INC COM 501147102 4,324 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
KURA ONCOLOGY INC COM 50127T109 3,980 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 395 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 6,857 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 110,613 56,724,650 SH   DFND 1,2,3,4 61,045,864 0 0
MASTERCARD INC CL A 57636Q104 24,156 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 6,200 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MERUS N V COM N5749R100 6,050 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 6,020 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MODERNA INC COM 60770K107 89,850 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
MORPHIC HLDG INC COM 61775R105 26,706 1,819,186 SH   DFND 1,2,3,4,5,6 1,819,186 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 3,012 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
PASSAGE BIO INC COM 702712100 3,938 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
PAYPAL HLDGS INC COM 70450Y103 42,126 440,000 SH   DFND 1,2,3,4,5,6 440,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,426 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 2,438 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 14,845 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 7,137 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
PROTHENA CORP PLC SHS G72800108 3,210 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
REGENXBIO INC COM 75901B107 8,095 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
REPLIMUNE GROUP INC COM 76029N106 5,982 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 546 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 17,283 3,883,791 SH   DFND 1,2,3,4,5,6 3,883,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 10,052 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 30,833 2,546,040 SH   DFND 1,2,3,4,5,6 2,546,040 0 0
SCHRODINGER INC COM 80810D103 38,698 897,445 SH   DFND 1,2,3,4,5,6 897,445 0 0
SELECTA BIOSCIENCES INC COM 816212104 8,227 3,413,629 SH   DFND 1,2,3,4,5,6 3,413,629 0 0
SOLID BIOSCIENCES INC COM 83422E105 4,302 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 38,720 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 4,654 576,000 SH   DFND 1,2,3,4,5,6 576,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,450 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 5,725 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
STONECO LTD COM CL A G85158106 8,708 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 3,001 506,138 SH   DFND 1,2,3,4,5,6 506,138 0 0
TCR2 THERAPEUTICS INC COM 87808K106 3,096 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TG THERAPEUTICS INC COM 88322Q108 9,840 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
TRANSLATE BIO INC COM 89374L104 5,982 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
TRICIDA INC COM 89610F101 7,920 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 4,040 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 10,904 465,000 SH   DFND 1,2,3,4,5,6 465,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 13,398 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 11,168 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
UNIQURE NV SHS N90064101 54,568 1,150,000 SH   DFND 1,2,3,4,5,6 1,150,000 0 0
WW INTL INC COM 98262P101 250,577 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 10,440 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 32,418 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0