The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 10X Genomics Inc Class A | CL A COM | 88025U109 | 99 | 1,589 | SH | DFND | 3 | 1,589 | 0 | 0 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 27,615 | 566,817 | SH | DFND | 1 | 566,817 | 0 | 0 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 68,407 | 1,404,077 | SH | SOLE | 0 | 1,299,390 | 0 | 104,687 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 20,035 | 411,221 | SH | DFND | 3 | 278,344 | 0 | 132,877 | |
| 58.Com Inc Adr | SPON ADR REP A | 31680Q104 | 100,794 | 2,068,844 | SH | DFND | 2 | 1,909,649 | 0 | 159,195 | |
| AJ Gallagher & Co | COM | 363576109 | 267,880 | 3,286,464 | SH | DFND | 2 | 3,028,373 | 0 | 258,091 | |
| AJ Gallagher & Co | COM | 363576109 | 81,648 | 1,001,693 | SH | DFND | 1 | 1,001,693 | 0 | 0 | |
| AJ Gallagher & Co | COM | 363576109 | 51,925 | 637,034 | SH | DFND | 3 | 433,372 | 0 | 203,662 | |
| AJ Gallagher & Co | COM | 363576109 | 185,068 | 2,270,498 | SH | SOLE | 0 | 2,108,552 | 0 | 161,946 | |
| Abiomed | COM | 003654100 | 177,328 | 1,221,607 | SH | DFND | 2 | 1,164,996 | 0 | 56,611 | |
| Abiomed | COM | 003654100 | 109,929 | 757,296 | SH | DFND | 1 | 757,296 | 0 | 0 | |
| Abiomed | COM | 003654100 | 23,546 | 162,204 | SH | DFND | 3 | 117,042 | 0 | 45,162 | |
| Abiomed | COM | 003654100 | 84,958 | 585,273 | SH | SOLE | 0 | 554,489 | 0 | 30,784 | |
| Acacia Research Corp | ACACIA TCH COM | 003881307 | 182 | 82,038 | SH | DFND | 1 | 82,038 | 0 | 0 | |
| Acacia Research Corp | ACACIA TCH COM | 003881307 | 281 | 126,652 | SH | SOLE | 0 | 126,652 | 0 | 0 | |
| Activision Blizzard Inc | COM | 00507V109 | 41,960 | 705,451 | SH | DFND | 1 | 705,451 | 0 | 0 | |
| Activision Blizzard Inc | COM | 00507V109 | 54,184 | 910,960 | SH | DFND | 2 | 817,565 | 0 | 93,395 | |
| Activision Blizzard Inc | COM | 00507V109 | 604 | 10,148 | SH | DFND | 3 | 10,148 | 0 | 0 | |
| Activision Blizzard Inc | COM | 00507V109 | 11,516 | 193,606 | SH | SOLE | 0 | 193,606 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 5,538 | 2,035,855 | SH | DFND | 1 | 2,035,855 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 3,276 | 1,204,553 | SH | DFND | 2 | 530,691 | 0 | 673,862 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 1,906 | 700,697 | SH | SOLE | 0 | 700,697 | 0 | 0 | |
| Adaptimmune Therapeutics ADR | SPONDS ADR | 00653A107 | 1,123 | 412,918 | SH | DFND | 3 | 412,918 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 3,511 | 1,281,541 | SH | DFND | 2 | 551,223 | 0 | 730,318 | |
| Aduro Biotechnology | COM | 00739L101 | 5,428 | 1,980,937 | SH | DFND | 1 | 1,980,937 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 1,182 | 431,553 | SH | DFND | 3 | 431,553 | 0 | 0 | |
| Aduro Biotechnology | COM | 00739L101 | 1,604 | 585,293 | SH | SOLE | 0 | 585,293 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 14,385 | 235,970 | SH | DFND | 2 | 104,225 | 0 | 131,745 | |
| Aerovironment | COM | 008073108 | 17,661 | 289,717 | SH | DFND | 1 | 289,717 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 4,881 | 80,076 | SH | DFND | 3 | 80,076 | 0 | 0 | |
| Aerovironment | COM | 008073108 | 13,446 | 220,567 | SH | SOLE | 0 | 220,567 | 0 | 0 | |
| Albemarle Corp | COM | 012653101 | 36,270 | 643,420 | SH | DFND | 1 | 643,420 | 0 | 0 | |
| Albemarle Corp | COM | 012653101 | 109,015 | 1,933,918 | SH | DFND | 2 | 1,782,366 | 0 | 151,552 | |
| Albemarle Corp | COM | 012653101 | 80,824 | 1,433,814 | SH | SOLE | 0 | 1,338,730 | 0 | 95,084 | |
| Albemarle Corp | COM | 012653101 | 20,839 | 369,690 | SH | DFND | 3 | 250,801 | 0 | 118,889 | |
| Alector Inc | COM | 014442107 | 50 | 2,072 | SH | DFND | 3 | 2,072 | 0 | 0 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 694,072 | 3,568,861 | SH | DFND | 1 | 3,568,861 | 0 | 0 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 1,793,780 | 9,223,467 | SH | SOLE | 0 | 7,684,186 | 0 | 1,539,281 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 15,623 | 80,332 | SH | DFND | 4 | 80,332 | 0 | 0 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 555,499 | 2,856,330 | SH | DFND | 3 | 920,431 | 0 | 1,935,899 | |
| Alibaba Group Holding Sponsored ADR | SPONSORED ADS | 01609W102 | 6,888,050 | 35,417,780 | SH | DFND | 2 | 24,147,887 | 0 | 11,269,893 | |
| Align Technology Inc | COM | 016255101 | 7,600 | 43,691 | SH | DFND | 2 | 43,691 | 0 | 0 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 208,778 | 1,918,035 | SH | DFND | 1 | 1,918,035 | 0 | 0 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 387,934 | 3,563,931 | SH | DFND | 2 | 3,092,674 | 0 | 471,257 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 69,168 | 635,445 | SH | DFND | 3 | 502,405 | 0 | 133,040 | |
| Alnylam Pharmaceuticals | COM | 02043Q107 | 249,741 | 2,294,358 | SH | SOLE | 0 | 2,188,703 | 0 | 105,655 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 28,511 | 24,537 | SH | DFND | 1 | 24,537 | 0 | 0 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 45,523 | 39,178 | SH | DFND | 2 | 37,323 | 0 | 1,855 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 95,072 | 81,821 | SH | SOLE | 0 | 81,821 | 0 | 0 | |
| Alphabet Inc Class A | CAP STK CL A | 02079K305 | 9,600 | 8,262 | SH | DFND | 3 | 6,589 | 0 | 1,673 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 443,489 | 381,394 | SH | DFND | 1 | 381,394 | 0 | 0 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 172,046 | 147,957 | SH | DFND | 3 | 99,418 | 0 | 48,539 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 1,558,060 | 1,339,909 | SH | DFND | 2 | 839,958 | 0 | 499,951 | |
| Alphabet Inc Class C | CAP STK CL C | 02079K107 | 773,048 | 664,810 | SH | SOLE | 0 | 530,766 | 0 | 134,044 | |
| Amazon.Com | COM | 023135106 | 925,446 | 474,656 | SH | DFND | 1 | 474,656 | 0 | 0 | |
| Amazon.Com | COM | 023135106 | 2,406,282 | 1,234,168 | SH | SOLE | 0 | 1,046,775 | 0 | 187,393 | |
| Amazon.Com | COM | 023135106 | 322,452 | 165,384 | SH | DFND | 3 | 109,520 | 0 | 55,864 | |
| Amazon.Com | COM | 023135106 | 4,728,092 | 2,425,011 | SH | DFND | 2 | 1,649,407 | 0 | 775,604 | |
| Ambarella | SHS | G037AX101 | 7,163 | 147,500 | SH | DFND | 1 | 147,500 | 0 | 0 | |
| Ambarella | SHS | G037AX101 | 6,241 | 128,524 | SH | DFND | 2 | 56,998 | 0 | 71,526 | |
| Ambarella | SHS | G037AX101 | 2,145 | 44,181 | SH | DFND | 3 | 44,181 | 0 | 0 | |
| Ambarella | SHS | G037AX101 | 4,740 | 97,605 | SH | SOLE | 0 | 97,605 | 0 | 0 | |
| Ameren | COM | 023608102 | 517 | 7,100 | SH | DFND | 1 | 7,100 | 0 | 0 | |
| American Express | COM | 025816109 | 12,138 | 141,786 | SH | DFND | 2 | 141,786 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 15 | 170 | SH | DFND | 3 | 170 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 12,175 | 135,801 | SH | DFND | 1 | 135,801 | 0 | 0 | |
| Analog Devices | COM | 032654105 | 678 | 7,560 | SH | DFND | 2 | 0 | 0 | 7,560 | |
| Analog Devices | COM | 032654105 | 14,675 | 163,688 | SH | SOLE | 0 | 163,688 | 0 | 0 | |
| Anaplan Inc Common | COM | 03272L108 | 56,636 | 1,871,644 | SH | SOLE | 0 | 1,871,644 | 0 | 0 | |
| Annaly Capital Man. | COM | 035710409 | 110 | 21,682 | SH | DFND | 1 | 21,682 | 0 | 0 | |
| Anthem Inc | COM | 036752103 | 119,742 | 527,403 | SH | DFND | 1 | 527,403 | 0 | 0 | |
| Anthem Inc | COM | 036752103 | 431,638 | 1,901,156 | SH | DFND | 2 | 1,753,780 | 0 | 147,376 | |
| Anthem Inc | COM | 036752103 | 84,187 | 370,802 | SH | DFND | 3 | 249,959 | 0 | 120,843 | |
| Anthem Inc | COM | 036752103 | 294,634 | 1,297,717 | SH | SOLE | 0 | 1,200,892 | 0 | 96,825 | |
| Apollo Commercial Real Estate Finance REIT | COM | 03762U105 | 110 | 14,800 | SH | DFND | 1 | 14,800 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 50,864 | 1,264,335 | SH | DFND | 1 | 1,264,335 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 31,966 | 794,588 | SH | SOLE | 0 | 794,588 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 6,664 | 165,641 | SH | DFND | 3 | 165,641 | 0 | 0 | |
| Appian Corp | CL A | 03782L101 | 53,851 | 1,338,587 | SH | DFND | 2 | 1,088,780 | 0 | 249,807 | |
| Apple | COM | 037833100 | 13 | 52 | SH | DFND | 3 | 52 | 0 | 0 | |
| Apple | COM | 037833100 | 668 | 2,625 | SH | DFND | 2 | 0 | 0 | 2,625 | |
| Apple | COM | 037833100 | 10,496 | 41,274 | SH | DFND | 1 | 41,274 | 0 | 0 | |
| Apple | COM | 037833100 | 12,794 | 50,311 | SH | SOLE | 0 | 50,311 | 0 | 0 | |
| Atlassian Corp Plc | CL A | G06242104 | 97,695 | 711,749 | SH | DFND | 1 | 711,749 | 0 | 0 | |
| Atlassian Corp Plc | CL A | G06242104 | 215,475 | 1,569,828 | SH | SOLE | 0 | 810,025 | 0 | 759,803 | |
| Atlassian Corp Plc | CL A | G06242104 | 51,402 | 374,486 | SH | DFND | 3 | 242,598 | 0 | 131,888 | |
| Atlassian Corp Plc | CL A | G06242104 | 675,312 | 4,919,951 | SH | DFND | 2 | 1,736,505 | 0 | 3,183,446 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 28,485 | 401,089 | SH | DFND | 1 | 401,089 | 0 | 0 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 103,468 | 1,456,882 | SH | DFND | 2 | 1,345,556 | 0 | 111,326 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 20,416 | 287,464 | SH | DFND | 3 | 193,926 | 0 | 93,538 | |
| Autohome Inc - ADR | SP ADR RP CL A | 05278C107 | 73,309 | 1,032,224 | SH | SOLE | 0 | 959,027 | 0 | 73,197 | |
| Axogen Inc | COM | 05463X106 | 3,735 | 359,100 | SH | DFND | 1 | 359,100 | 0 | 0 | |
| Axogen Inc | COM | 05463X106 | 3,998 | 384,438 | SH | DFND | 2 | 169,238 | 0 | 215,200 | |
| Axogen Inc | COM | 05463X106 | 1,764 | 169,600 | SH | SOLE | 0 | 169,600 | 0 | 0 | |
| Axogen Inc | COM | 05463X106 | 1,346 | 129,392 | SH | DFND | 3 | 129,392 | 0 | 0 | |
| Axon Enterprise Inc | COM | 05464C101 | 28,464 | 402,203 | SH | DFND | 3 | 294,567 | 0 | 107,636 | |
| Axon Enterprise Inc | COM | 05464C101 | 44,808 | 633,148 | SH | DFND | 1 | 633,148 | 0 | 0 | |
| Axon Enterprise Inc | COM | 05464C101 | 133,792 | 1,890,522 | SH | DFND | 2 | 1,648,946 | 0 | 241,576 | |
| Axon Enterprise Inc | COM | 05464C101 | 88,685 | 1,253,151 | SH | SOLE | 0 | 1,168,781 | 0 | 84,370 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 17,640 | 175,017 | SH | DFND | 3 | 14,397 | 0 | 160,620 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 497,982 | 4,940,788 | SH | DFND | 2 | 4,426,169 | 0 | 514,619 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 8,184 | 81,202 | SH | DFND | 1 | 81,202 | 0 | 0 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 894 | 8,867 | SH | DFND | 4 | 8,867 | 0 | 0 | |
| Baidu.com Sponsored ADR | SPON ADR REP A | 056752108 | 789 | 7,831 | SH | SOLE | 0 | 7,831 | 0 | 0 | |
| BanColombia Pref ADR | SPON ADR PREF | 05968L102 | 6,419 | 257,155 | SH | DFND | 2 | 0 | 0 | 257,155 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 14,636 | 3,604,805 | SH | DFND | 1 | 3,604,805 | 0 | 0 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 95,655 | 23,560,253 | SH | DFND | 2 | 11,273,197 | 0 | 12,287,056 | |
| Banco Bradesco Pn ADR | SP ADR PFD NEW | 059460303 | 8,953 | 2,205,100 | SH | DFND | 3 | 2,139,239 | 0 | 65,861 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 14,856 | 531,708 | SH | DFND | 1 | 531,708 | 0 | 0 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 11,963 | 428,185 | SH | DFND | 2 | 189,386 | 0 | 238,799 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 4,084 | 146,166 | SH | DFND | 3 | 146,166 | 0 | 0 | |
| Baozun Spn Adr 1:1 | SPONSORED ADR | 06684L103 | 8,217 | 294,100 | SH | SOLE | 0 | 294,100 | 0 | 0 | |
| Beigene Ltd | SPONSORED ADR | 07725L102 | 6,601 | 53,616 | SH | DFND | 1 | 53,616 | 0 | 0 | |
| Beigene Ltd | SPONSORED ADR | 07725L102 | 30,581 | 248,407 | SH | DFND | 2 | 126,092 | 0 | 122,315 | |
| Benefitfocus Inc | COM | 08180D106 | 924 | 103,732 | SH | DFND | 3 | 103,732 | 0 | 0 | |
| Benefitfocus Inc | COM | 08180D106 | 2,481 | 278,500 | SH | DFND | 2 | 108,529 | 0 | 169,971 | |
| Benefitfocus Inc | COM | 08180D106 | 2,730 | 306,448 | SH | DFND | 1 | 306,448 | 0 | 0 | |
| Benefitfocus Inc | COM | 08180D106 | 2,017 | 226,368 | SH | SOLE | 0 | 226,368 | 0 | 0 | |
| BitAuto Holdings Ltd - ADR | SPONSORED ADS | 091727107 | 174 | 16,750 | SH | SOLE | 0 | 16,750 | 0 | 0 | |
| BlackRock Floating Rate Income | COM | 091941104 | 7,693 | 784,230 | SH | DFND | 1 | 784,230 | 0 | 0 | |
| Blackline | COM | 09239B109 | 13,821 | 262,705 | SH | DFND | 1 | 262,705 | 0 | 0 | |
| Blackline | COM | 09239B109 | 11,456 | 217,750 | SH | DFND | 2 | 95,955 | 0 | 121,795 | |
| Blackline | COM | 09239B109 | 3,891 | 73,962 | SH | DFND | 3 | 73,962 | 0 | 0 | |
| Blackline | COM | 09239B109 | 7,322 | 139,175 | SH | SOLE | 0 | 139,175 | 0 | 0 | |
| Blue Apron Holdings Inc | CL A | 09523Q101 | 1,789 | 148,506 | SH | DFND | 1 | 148,506 | 0 | 0 | |
| Blue Capital Reinsurance Holdings Fund (USD) | COM | G1190F107 | 714 | 615,658 | SH | DFND | 1 | 615,658 | 0 | 0 | |
| Bluebird Bio Inc | COM | 09609G100 | 28 | 608 | SH | DFND | 3 | 608 | 0 | 0 | |
| Bluebird Bio Inc | COM | 09609G100 | 31,942 | 695,000 | SH | SOLE | 0 | 695,000 | 0 | 0 | |
| BridgeBio Pharma Inc | COM | 10806X102 | 78 | 2,700 | SH | DFND | 3 | 2,700 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 156 | 4,555 | SH | DFND | 2 | 0 | 0 | 4,555 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 5 | 148 | SH | DFND | 3 | 148 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 3,352 | 98,030 | SH | DFND | 1 | 98,030 | 0 | 0 | |
| British Amer.Tobacco - ADR | SPONSORED ADR | 110448107 | 3,967 | 116,021 | SH | SOLE | 0 | 116,021 | 0 | 0 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 44,603 | 470,351 | SH | DFND | 1 | 470,351 | 0 | 0 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 157,418 | 1,659,997 | SH | DFND | 2 | 1,529,069 | 0 | 130,928 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 30,805 | 324,847 | SH | DFND | 3 | 220,050 | 0 | 104,797 | |
| Broadridge Finl.Sltn. | COM | 11133T103 | 107,175 | 1,130,183 | SH | SOLE | 0 | 1,046,618 | 0 | 83,565 | |
| CEVA Inc | COM | 157210105 | 1,332 | 53,447 | SH | DFND | 3 | 53,447 | 0 | 0 | |
| CEVA Inc | COM | 157210105 | 3,914 | 156,980 | SH | DFND | 1 | 156,980 | 0 | 0 | |
| CEVA Inc | COM | 157210105 | 3,792 | 152,116 | SH | DFND | 2 | 67,082 | 0 | 85,034 | |
| CEVA Inc | COM | 157210105 | 2,057 | 82,500 | SH | SOLE | 0 | 82,500 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 15,097 | 228,055 | SH | DFND | 1 | 228,055 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 867 | 13,103 | SH | DFND | 2 | 0 | 0 | 13,103 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 19 | 288 | SH | DFND | 3 | 288 | 0 | 0 | |
| CH Robinson Worldwide | COM NEW | 12541W209 | 18,292 | 276,315 | SH | SOLE | 0 | 276,315 | 0 | 0 | |
| CarMax Inc | COM | 143130102 | 14,165 | 263,146 | SH | DFND | 2 | 263,146 | 0 | 0 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 18,259 | 8,612,625 | SH | DFND | 3 | 437,193 | 0 | 8,175,432 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 51,715 | 24,393,748 | SH | DFND | 2 | 9,464,132 | 0 | 14,929,616 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 9,562 | 4,510,465 | SH | DFND | 1 | 4,510,465 | 0 | 0 | |
| Cemex ADR | SPON ADR NEW | 151290889 | 924 | 435,758 | SH | DFND | 4 | 435,758 | 0 | 0 | |
| Chegg | COM | 163092109 | 159,793 | 4,465,976 | SH | DFND | 1 | 4,465,976 | 0 | 0 | |
| Chegg | COM | 163092109 | 209,180 | 5,846,291 | SH | DFND | 2 | 5,228,804 | 0 | 617,487 | |
| Chegg | COM | 163092109 | 32,997 | 922,214 | SH | DFND | 3 | 716,903 | 0 | 205,311 | |
| Chegg | COM | 163092109 | 114,034 | 3,187,099 | SH | SOLE | 0 | 3,067,885 | 0 | 119,214 | |
| Chewy Inc | CL A | 16679L109 | 84,396 | 2,251,158 | SH | DFND | 1 | 2,251,158 | 0 | 0 | |
| Chewy Inc | CL A | 16679L109 | 83,282 | 2,221,447 | SH | DFND | 2 | 2,221,447 | 0 | 0 | |
| Chewy Inc | CL A | 16679L109 | 25,333 | 675,714 | SH | SOLE | 0 | 675,714 | 0 | 0 | |
| Chewy Inc | CL A | 16679L109 | 1,182 | 31,532 | SH | DFND | 3 | 31,532 | 0 | 0 | |
| Chipotle Mexican Grill | COM | 169656105 | 28,426 | 43,438 | SH | DFND | 1 | 43,438 | 0 | 0 | |
| Chipotle Mexican Grill | COM | 169656105 | 19,458 | 29,734 | SH | DFND | 3 | 20,260 | 0 | 9,474 | |
| Chipotle Mexican Grill | COM | 169656105 | 98,709 | 150,839 | SH | DFND | 2 | 139,335 | 0 | 11,504 | |
| Chipotle Mexican Grill | COM | 169656105 | 66,232 | 101,211 | SH | SOLE | 0 | 93,773 | 0 | 7,438 | |
| CoStar Group | COM | 22160N109 | 109,428 | 186,352 | SH | DFND | 2 | 186,352 | 0 | 0 | |
| CoStar Group | COM | 22160N109 | 97,355 | 165,792 | SH | DFND | 1 | 165,792 | 0 | 0 | |
| CoStar Group | COM | 22160N109 | 1,381 | 2,352 | SH | DFND | 3 | 2,352 | 0 | 0 | |
| CoStar Group | COM | 22160N109 | 30,440 | 51,838 | SH | SOLE | 0 | 51,838 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 27,261 | 616,070 | SH | SOLE | 0 | 616,070 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 29 | 659 | SH | DFND | 3 | 659 | 0 | 0 | |
| Coca Cola | COM | 191216100 | 1,228 | 27,743 | SH | DFND | 2 | 0 | 0 | 27,743 | |
| Coca Cola | COM | 191216100 | 22,268 | 503,239 | SH | DFND | 1 | 503,239 | 0 | 0 | |
| Codexis | COM | 192005106 | 14,834 | 1,329,233 | SH | DFND | 1 | 1,329,233 | 0 | 0 | |
| Codexis | COM | 192005106 | 15,195 | 1,361,518 | SH | DFND | 2 | 602,665 | 0 | 758,853 | |
| Codexis | COM | 192005106 | 5,158 | 462,194 | SH | DFND | 3 | 462,194 | 0 | 0 | |
| Codexis | COM | 192005106 | 10,428 | 934,372 | SH | SOLE | 0 | 934,372 | 0 | 0 | |
| Consolidated Edison | COM | 209115104 | 688 | 8,820 | SH | DFND | 1 | 8,820 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 1,196 | 26,411 | SH | DFND | 4 | 26,411 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 24,019 | 530,345 | SH | DFND | 3 | 27,459 | 0 | 502,886 | |
| Copa Holdings S A | CL A | P31076105 | 99,375 | 2,194,190 | SH | DFND | 2 | 1,506,218 | 0 | 687,972 | |
| Copa Holdings S A | CL A | P31076105 | 5,705 | 125,969 | SH | DFND | 1 | 125,969 | 0 | 0 | |
| Copa Holdings S A | CL A | P31076105 | 12,583 | 277,829 | SH | SOLE | 0 | 277,829 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 14,207 | 99,302 | SH | DFND | 1 | 99,302 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 211,955 | 1,481,476 | SH | DFND | 2 | 829,622 | 0 | 651,854 | |
| Credicorp | COM | G2519Y108 | 28,855 | 201,682 | SH | DFND | 3 | 10,248 | 0 | 191,434 | |
| Credicorp | COM | G2519Y108 | 1,444 | 10,091 | SH | DFND | 4 | 10,091 | 0 | 0 | |
| Credicorp | COM | G2519Y108 | 17,391 | 121,553 | SH | SOLE | 0 | 121,553 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 5,619 | 100,721 | SH | DFND | 1 | 100,721 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 332 | 5,942 | SH | DFND | 2 | 0 | 0 | 5,942 | |
| Cullen/Frost Bankers | COM | 229899109 | 6,810 | 122,059 | SH | SOLE | 0 | 122,059 | 0 | 0 | |
| Cullen/Frost Bankers | COM | 229899109 | 7 | 128 | SH | DFND | 3 | 128 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 9,420 | 110,100 | SH | DFND | 1 | 110,100 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 3,528 | 41,231 | SH | DFND | 3 | 41,231 | 0 | 0 | |
| CyberArk Software Ltd | SHS | M2682V108 | 10,320 | 120,617 | SH | DFND | 2 | 53,317 | 0 | 67,300 | |
| CyberArk Software Ltd | SHS | M2682V108 | 6,888 | 80,500 | SH | SOLE | 0 | 80,500 | 0 | 0 | |
| Deere & Co | COM | 244199105 | 4,477 | 32,401 | SH | DFND | 2 | 23,827 | 0 | 8,574 | |
| Deere & Co | COM | 244199105 | 6,847 | 49,559 | SH | DFND | 1 | 49,559 | 0 | 0 | |
| Deere & Co | COM | 244199105 | 2,423 | 17,536 | SH | DFND | 3 | 17,536 | 0 | 0 | |
| Denali Therapeutics | COM | 24823R105 | 35,390 | 2,021,153 | SH | DFND | 1 | 2,021,153 | 0 | 0 | |
| Denali Therapeutics | COM | 24823R105 | 35,614 | 2,033,925 | SH | DFND | 2 | 2,033,925 | 0 | 0 | |
| Denali Therapeutics | COM | 24823R105 | 1,972 | 112,635 | SH | DFND | 3 | 80,858 | 0 | 31,777 | |
| Denali Therapeutics | COM | 24823R105 | 86,885 | 4,962,039 | SH | SOLE | 0 | 4,962,039 | 0 | 0 | |
| Dexcom Inc | COM | 252131107 | 815,706 | 3,029,325 | SH | DFND | 2 | 1,098,863 | 0 | 1,930,462 | |
| Dexcom Inc | COM | 252131107 | 150,674 | 559,565 | SH | DFND | 1 | 559,565 | 0 | 0 | |
| Dexcom Inc | COM | 252131107 | 74,222 | 275,640 | SH | DFND | 3 | 198,277 | 0 | 77,363 | |
| Dexcom Inc | COM | 252131107 | 260,121 | 966,022 | SH | SOLE | 0 | 519,665 | 0 | 446,357 | |
| Digimarc | COM | 25381B101 | 2,429 | 186,145 | SH | DFND | 1 | 186,145 | 0 | 0 | |
| Digimarc | COM | 25381B101 | 3,806 | 291,675 | SH | DFND | 2 | 127,997 | 0 | 163,678 | |
| Digimarc | COM | 25381B101 | 1,293 | 99,043 | SH | DFND | 3 | 99,043 | 0 | 0 | |
| Digimarc | COM | 25381B101 | 2,019 | 154,711 | SH | SOLE | 0 | 154,711 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 6,377 | 117,629 | SH | DFND | 1 | 117,629 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 374 | 6,904 | SH | DFND | 2 | 0 | 0 | 6,904 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 8 | 148 | SH | DFND | 3 | 148 | 0 | 0 | |
| Dolby Laboratories 'A' | COM | 25659T107 | 7,705 | 142,139 | SH | SOLE | 0 | 142,139 | 0 | 0 | |
| EOG Resources | COM | 26875P101 | 130,704 | 3,638,747 | SH | DFND | 2 | 3,364,480 | 0 | 274,267 | |
| EOG Resources | COM | 26875P101 | 35,794 | 996,503 | SH | DFND | 1 | 996,503 | 0 | 0 | |
| EOG Resources | COM | 26875P101 | 17,567 | 489,070 | SH | DFND | 3 | 268,003 | 0 | 221,067 | |
| EOG Resources | COM | 26875P101 | 83,574 | 2,326,681 | SH | SOLE | 0 | 2,150,673 | 0 | 176,008 | |
| Ecolab | COM | 278865100 | 6,615 | 42,448 | SH | DFND | 1 | 42,448 | 0 | 0 | |
| Ecolab | COM | 278865100 | 2,403 | 15,421 | SH | DFND | 3 | 15,421 | 0 | 0 | |
| Ecolab | COM | 278865100 | 4,380 | 28,106 | SH | DFND | 2 | 20,643 | 0 | 7,463 | |
| Edwards Lifesciences Corp | COM | 28176E108 | 214 | 1,137 | SH | DFND | 3 | 1,137 | 0 | 0 | |
| Estee Lauder 'A' | COM | 518439104 | 25,090 | 157,459 | SH | DFND | 2 | 157,459 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 10,497 | 1,437,899 | SH | DFND | 2 | 1,437,899 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 10,184 | 1,395,096 | SH | DFND | 1 | 1,395,096 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 144 | 19,741 | SH | DFND | 3 | 19,741 | 0 | 0 | |
| Eventbrite Inc Class A | COM CL A | 29975E109 | 2,370 | 324,617 | SH | SOLE | 0 | 324,617 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 5,003 | 190,608 | SH | DFND | 1 | 190,608 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 5,770 | 219,801 | SH | DFND | 2 | 96,962 | 0 | 122,839 | |
| EverQuote Inc | COM CL A | 30041R108 | 1,950 | 74,282 | SH | DFND | 3 | 74,282 | 0 | 0 | |
| EverQuote Inc | COM CL A | 30041R108 | 3,933 | 149,814 | SH | SOLE | 0 | 149,814 | 0 | 0 | |
| Eversource Energy | COM | 30040W108 | 817 | 10,450 | SH | DFND | 1 | 10,450 | 0 | 0 | |
| Exact Sciences | COM | 30063P105 | 13,371 | 230,528 | SH | DFND | 1 | 230,528 | 0 | 0 | |
| Exact Sciences | COM | 30063P105 | 13,267 | 228,745 | SH | DFND | 2 | 105,488 | 0 | 123,257 | |
| Exact Sciences | COM | 30063P105 | 5,628 | 97,042 | SH | DFND | 3 | 89,445 | 0 | 7,597 | |
| Exact Sciences | COM | 30063P105 | 10,057 | 173,392 | SH | SOLE | 0 | 173,392 | 0 | 0 | |
| Exelon Corporation | COM | 30161N101 | 572 | 15,550 | SH | DFND | 1 | 15,550 | 0 | 0 | |
| Facebook Cl.A | CL A | 30303M102 | 326,390 | 1,956,773 | SH | DFND | 1 | 1,956,773 | 0 | 0 | |
| Facebook Cl.A | CL A | 30303M102 | 1,465,849 | 8,788,065 | SH | DFND | 2 | 4,589,828 | 0 | 4,198,237 | |
| Facebook Cl.A | CL A | 30303M102 | 138,097 | 827,917 | SH | DFND | 3 | 546,396 | 0 | 281,521 | |
| Facebook Cl.A | CL A | 30303M102 | 620,550 | 3,720,326 | SH | SOLE | 0 | 2,662,126 | 0 | 1,058,200 | |
| Farfetch | ORD SHS CL A | 30744W107 | 2,162 | 273,614 | SH | DFND | 1 | 273,614 | 0 | 0 | |
| Farfetch | ORD SHS CL A | 30744W107 | 796 | 100,755 | SH | DFND | 3 | 100,755 | 0 | 0 | |
| Farfetch | ORD SHS CL A | 30744W107 | 15,240 | 1,929,063 | SH | SOLE | 0 | 1,401,206 | 0 | 527,857 | |
| Faro Technologies | COM | 311642102 | 4,526 | 101,715 | SH | DFND | 1 | 101,715 | 0 | 0 | |
| Faro Technologies | COM | 311642102 | 7,129 | 160,196 | SH | DFND | 2 | 71,049 | 0 | 89,147 | |
| Faro Technologies | COM | 311642102 | 2,405 | 54,052 | SH | DFND | 3 | 54,052 | 0 | 0 | |
| Faro Technologies | COM | 311642102 | 4,801 | 107,880 | SH | SOLE | 0 | 107,880 | 0 | 0 | |
| Fastenal | COM | 311900104 | 23,597 | 755,094 | SH | DFND | 1 | 755,094 | 0 | 0 | |
| Fastenal | COM | 311900104 | 14,230 | 455,376 | SH | DFND | 2 | 419,092 | 0 | 36,284 | |
| Fastenal | COM | 311900104 | 25,803 | 825,683 | SH | SOLE | 0 | 825,683 | 0 | 0 | |
| Fastenal | COM | 311900104 | 2,634 | 84,301 | SH | DFND | 3 | 53,390 | 0 | 30,911 | |
| Ferrari NV | COM | N3167Y103 | 1,758,943 | 11,324,952 | SH | DFND | 2 | 8,496,745 | 0 | 2,828,207 | |
| Ferrari NV | COM | N3167Y103 | 311,098 | 2,003,000 | SH | SOLE | 0 | 2,003,000 | 0 | 0 | |
| Fiat Chrysler Automobiles | SHS | N31738102 | 249,151 | 34,550,994 | SH | DFND | 2 | 25,119,835 | 0 | 9,431,159 | |
| First Republic Bank | COM | 33616C100 | 5,881 | 71,471 | SH | DFND | 3 | 51,358 | 0 | 20,113 | |
| First Republic Bank | COM | 33616C100 | 35,975 | 437,222 | SH | SOLE | 0 | 437,222 | 0 | 0 | |
| First Republic Bank | COM | 33616C100 | 110,545 | 1,343,524 | SH | DFND | 1 | 1,343,524 | 0 | 0 | |
| First Republic Bank | COM | 33616C100 | 129,984 | 1,579,773 | SH | DFND | 2 | 1,579,773 | 0 | 0 | |
| Fortive Corp | COM | 34959J108 | 1,537 | 27,853 | SH | SOLE | 0 | 27,853 | 0 | 0 | |
| Fortive Corp | COM | 34959J108 | 1,660 | 30,085 | SH | DFND | 3 | 18,937 | 0 | 11,148 | |
| Fortive Corp | COM | 34959J108 | 2,871 | 52,014 | SH | DFND | 1 | 52,014 | 0 | 0 | |
| Fortive Corp | COM | 34959J108 | 8,623 | 156,234 | SH | DFND | 2 | 156,234 | 0 | 0 | |
| Glaukos Corp | COM | 377322102 | 49,067 | 1,589,971 | SH | DFND | 1 | 1,589,971 | 0 | 0 | |
| Glaukos Corp | COM | 377322102 | 46,243 | 1,498,486 | SH | DFND | 2 | 1,473,176 | 0 | 25,310 | |
| Glaukos Corp | COM | 377322102 | 3,067 | 99,377 | SH | DFND | 3 | 89,428 | 0 | 9,949 | |
| Glaukos Corp | COM | 377322102 | 14,070 | 455,918 | SH | SOLE | 0 | 455,918 | 0 | 0 | |
| Grifols ADR | SP ADR REP B NVT | 398438408 | 56,175 | 2,789,250 | SH | DFND | 2 | 1,913,401 | 0 | 875,849 | |
| Grifols ADR | SP ADR REP B NVT | 398438408 | 7,783 | 386,447 | SH | SOLE | 0 | 386,447 | 0 | 0 | |
| Grubhub Inc | COM | 400110102 | 114,179 | 2,803,315 | SH | DFND | 1 | 2,803,315 | 0 | 0 | |
| Grubhub Inc | COM | 400110102 | 173,802 | 4,267,171 | SH | DFND | 2 | 3,904,261 | 0 | 362,910 | |
| Grubhub Inc | COM | 400110102 | 23,844 | 585,405 | SH | DFND | 3 | 446,573 | 0 | 138,832 | |
| Grubhub Inc | COM | 400110102 | 85,856 | 2,107,923 | SH | SOLE | 0 | 2,007,211 | 0 | 100,712 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 24,668 | 641,387 | SH | DFND | 2 | 534,065 | 0 | 107,322 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 5,395 | 140,263 | SH | DFND | 3 | 78,483 | 0 | 61,780 | |
| HDFC Bank ADR | ADR REPS 3 SHS | 40415F101 | 55,140 | 1,433,688 | SH | SOLE | 0 | 1,317,134 | 0 | 116,554 | |
| HEICO | COM | 422806109 | 11,412 | 152,960 | SH | DFND | 1 | 152,960 | 0 | 0 | |
| HEICO | COM | 422806109 | 5,467 | 73,276 | SH | SOLE | 0 | 73,276 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 26,763 | 418,832 | SH | DFND | 1 | 418,832 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 45,761 | 716,131 | SH | DFND | 2 | 716,131 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 490 | 7,666 | SH | DFND | 3 | 7,666 | 0 | 0 | |
| HEICO 'A' | CL A | 422806208 | 5,631 | 88,117 | SH | SOLE | 0 | 88,117 | 0 | 0 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 4,384 | 258,616 | SH | DFND | 1 | 258,616 | 0 | 0 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 3,420 | 201,782 | SH | SOLE | 0 | 201,782 | 0 | 0 | |
| HUYA ADR | ADS REP SHS A | 44852D108 | 6 | 357 | SH | DFND | 3 | 357 | 0 | 0 | |
| Health Catalyst Inc | COM | 42225T107 | 88 | 3,352 | SH | DFND | 3 | 3,352 | 0 | 0 | |
| Howard Hughes | COM | 44267D107 | 22,029 | 436,040 | SH | DFND | 1 | 436,040 | 0 | 0 | |
| Howard Hughes | COM | 44267D107 | 78,394 | 1,551,735 | SH | DFND | 2 | 1,431,091 | 0 | 120,644 | |
| Howard Hughes | COM | 44267D107 | 15,308 | 303,015 | SH | DFND | 3 | 205,703 | 0 | 97,312 | |
| Howard Hughes | COM | 44267D107 | 53,845 | 1,065,813 | SH | SOLE | 0 | 988,886 | 0 | 76,927 | |
| Hutchison China Meditech | SPONSORED ADR | 44842L103 | 508 | 28,459 | SH | DFND | 1 | 28,459 | 0 | 0 | |
| Hutchison China Meditech | SPONSORED ADR | 44842L103 | 3,412 | 191,146 | SH | DFND | 3 | 0 | 0 | 191,146 | |
| ICICI Bank ADR | ADR | 45104G104 | 63,324 | 7,449,855 | SH | DFND | 1 | 7,449,855 | 0 | 0 | |
| ICICI Bank ADR | ADR | 45104G104 | 61,492 | 7,234,300 | SH | DFND | 2 | 6,445,972 | 0 | 788,328 | |
| ICICI Bank ADR | ADR | 45104G104 | 30,637 | 3,604,374 | SH | DFND | 3 | 2,346,922 | 0 | 1,257,452 | |
| ICICI Bank ADR | ADR | 45104G104 | 4,588 | 539,749 | SH | DFND | 4 | 539,749 | 0 | 0 | |
| ICICI Bank ADR | ADR | 45104G104 | 86,608 | 10,189,136 | SH | SOLE | 0 | 9,596,528 | 0 | 592,608 | |
| IPG Photonics Corp | COM | 44980X109 | 3,885 | 35,224 | SH | DFND | 3 | 35,224 | 0 | 0 | |
| IPG Photonics Corp | COM | 44980X109 | 11,568 | 104,901 | SH | DFND | 2 | 46,392 | 0 | 58,509 | |
| IPG Photonics Corp | COM | 44980X109 | 8,817 | 79,947 | SH | DFND | 1 | 79,947 | 0 | 0 | |
| IPG Photonics Corp | COM | 44980X109 | 8,121 | 73,636 | SH | SOLE | 0 | 73,636 | 0 | 0 | |
| Illumina | COM | 452327109 | 441,960 | 1,618,188 | SH | DFND | 1 | 1,618,188 | 0 | 0 | |
| Illumina | COM | 452327109 | 2,870,210 | 10,508,972 | SH | DFND | 2 | 6,526,750 | 0 | 3,982,222 | |
| Illumina | COM | 452327109 | 1,343,953 | 4,920,742 | SH | SOLE | 0 | 4,020,182 | 0 | 900,560 | |
| Illumina | COM | 452327109 | 156,000 | 571,176 | SH | DFND | 3 | 380,808 | 0 | 190,368 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 7,307 | 889,976 | SH | DFND | 1 | 889,976 | 0 | 0 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 2,597 | 316,310 | SH | DFND | 3 | 193,893 | 0 | 122,417 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 2,348 | 286,039 | SH | DFND | 2 | 198,753 | 0 | 87,286 | |
| Infosys Ltd ADR | SPONSORED ADR | 456788108 | 1,564 | 190,455 | SH | DFND | 4 | 190,455 | 0 | 0 | |
| Interactive Brokers Group | COM | 45841N107 | 19,957 | 462,282 | SH | DFND | 3 | 312,635 | 0 | 149,647 | |
| Interactive Brokers Group | COM | 45841N107 | 139,803 | 3,238,432 | SH | DFND | 2 | 3,095,599 | 0 | 142,833 | |
| Interactive Brokers Group | COM | 45841N107 | 74,357 | 1,722,422 | SH | DFND | 1 | 1,722,422 | 0 | 0 | |
| Interactive Brokers Group | COM | 45841N107 | 73,060 | 1,692,390 | SH | SOLE | 0 | 1,596,931 | 0 | 95,459 | |
| Intuitive Surgical | COM NEW | 46120E602 | 88,767 | 179,251 | SH | DFND | 1 | 179,251 | 0 | 0 | |
| Intuitive Surgical | COM NEW | 46120E602 | 618,588 | 1,249,142 | SH | DFND | 2 | 440,654 | 0 | 808,488 | |
| Intuitive Surgical | COM NEW | 46120E602 | 47,025 | 94,960 | SH | DFND | 3 | 61,660 | 0 | 33,300 | |
| Intuitive Surgical | COM NEW | 46120E602 | 318,343 | 642,845 | SH | SOLE | 0 | 449,727 | 0 | 193,118 | |
| Invesco Senior Income Trust | COM | 46131H107 | 7,062 | 2,193,291 | SH | DFND | 1 | 2,193,291 | 0 | 0 | |
| Invesco Senior Income Trust | COM | 46131H107 | 748 | 232,277 | SH | DFND | 3 | 232,277 | 0 | 0 | |
| Ionis Pharmaceuticals | COM | 462222100 | 38,780 | 820,220 | SH | DFND | 1 | 820,220 | 0 | 0 | |
| Ionis Pharmaceuticals | COM | 462222100 | 269,398 | 5,697,926 | SH | DFND | 2 | 2,015,549 | 0 | 3,682,377 | |
| Ionis Pharmaceuticals | COM | 462222100 | 85,479 | 1,807,923 | SH | SOLE | 0 | 923,478 | 0 | 884,445 | |
| Ionis Pharmaceuticals | COM | 462222100 | 19,839 | 419,614 | SH | DFND | 3 | 266,921 | 0 | 152,693 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 10,148 | 2,260,216 | SH | DFND | 1 | 2,260,216 | 0 | 0 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 112,976 | 25,161,785 | SH | DFND | 2 | 12,291,915 | 0 | 12,869,870 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 2,214 | 493,153 | SH | DFND | 4 | 493,153 | 0 | 0 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 54,645 | 12,170,359 | SH | DFND | 3 | 489,557 | 0 | 11,680,802 | |
| Itau Unibanco Holding SA-ADR | SPON ADR REP PFD | 465562106 | 9,422 | 2,098,498 | SH | SOLE | 0 | 2,098,498 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 76,378 | 1,885,867 | SH | DFND | 1 | 1,885,867 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 92,719 | 2,289,354 | SH | DFND | 2 | 651,035 | 0 | 1,638,319 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 71,170 | 1,757,292 | SH | DFND | 3 | 190,086 | 0 | 1,567,206 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 3,354 | 82,826 | SH | DFND | 4 | 82,826 | 0 | 0 | |
| JD.Com Inc - ADR | SPON ADR CL A | 47215P106 | 15,430 | 380,984 | SH | SOLE | 0 | 380,984 | 0 | 0 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 23,683 | 1,732,474 | SH | DFND | 1 | 1,732,474 | 0 | 0 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 56,596 | 4,140,197 | SH | SOLE | 0 | 3,841,959 | 0 | 298,238 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 16,143 | 1,180,936 | SH | DFND | 3 | 798,090 | 0 | 382,846 | |
| Jefferies Financial Group Inc | COM | 47233W109 | 80,883 | 5,916,795 | SH | DFND | 2 | 5,450,563 | 0 | 466,232 | |
| Jianpu Technology Inc- ADR | ADR | 47738D101 | 852 | 1,014,428 | SH | DFND | 1 | 1,014,428 | 0 | 0 | |
| Jianpu Technology Inc- ADR | ADR | 47738D101 | 738 | 878,974 | SH | SOLE | 0 | 878,974 | 0 | 0 | |
| Jumia Technologies Ag ADR | SPONSORED ADS | 48138M105 | 27,001 | 9,246,855 | SH | DFND | 2 | 8,964,242 | 0 | 282,613 | |
| Kaleido Biosciences Inc | COM | 483347100 | 1,516 | 246,500 | SH | DFND | 1 | 246,500 | 0 | 0 | |
| Kaleido Biosciences Inc | COM | 483347100 | 1,190 | 193,500 | SH | SOLE | 0 | 193,500 | 0 | 0 | |
| Kirby | COM | 497266106 | 41,769 | 960,871 | SH | DFND | 1 | 960,871 | 0 | 0 | |
| Kirby | COM | 497266106 | 146,343 | 3,366,521 | SH | DFND | 2 | 3,099,335 | 0 | 267,186 | |
| Kirby | COM | 497266106 | 99,519 | 2,289,372 | SH | SOLE | 0 | 2,118,721 | 0 | 170,651 | |
| Kirby | COM | 497266106 | 28,777 | 661,992 | SH | DFND | 3 | 449,198 | 0 | 212,794 | |
| Korea Electric Power ADR | SPONSORED ADR | 500631106 | 14 | 1,900 | SH | DFND | 2 | 1,900 | 0 | 0 | |
| Korea Electric Power ADR | SPONSORED ADR | 500631106 | 1,018 | 134,900 | SH | DFND | 3 | 134,900 | 0 | 0 | |
| LIBERTY MEDIA CORP | DEB 4.00011/1 | 530715AG6 | 21,739 | 32,556,000 | SH | DFND | 1 | 32,556,000 | 0 | 0 | |
| LIBERTY MEDIA CORP | DEB 4.00011/1 | 530715AG6 | 6 | 9,000 | SH | DFND | 2 | 9,000 | 0 | 0 | |
| LIBERTY MEDIA CORP | DEB 4.00011/1 | 530715AG6 | 1,140 | 1,708,000 | SH | DFND | 3 | 1,708,000 | 0 | 0 | |
| LendingTree | COM | 52603B107 | 47,647 | 259,810 | SH | DFND | 1 | 259,810 | 0 | 0 | |
| LendingTree | COM | 52603B107 | 104,993 | 572,511 | SH | DFND | 2 | 434,235 | 0 | 138,276 | |
| LendingTree | COM | 52603B107 | 28,582 | 155,851 | SH | DFND | 3 | 126,294 | 0 | 29,557 | |
| LendingTree | COM | 52603B107 | 66,433 | 362,250 | SH | SOLE | 0 | 343,934 | 0 | 18,316 | |
| Lindblad Expeditions Holdings | COM | 535219109 | 2,919 | 700,000 | SH | SOLE | 0 | 700,000 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 7,779 | 236,300 | SH | DFND | 1 | 236,300 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 9,616 | 292,100 | SH | DFND | 2 | 128,800 | 0 | 163,300 | |
| Liveramp Holdings Inc | COM | 53815P108 | 3,246 | 98,600 | SH | DFND | 3 | 98,600 | 0 | 0 | |
| Liveramp Holdings Inc | COM | 53815P108 | 6,110 | 185,600 | SH | SOLE | 0 | 185,600 | 0 | 0 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 18,804 | 700,329 | SH | DFND | 1 | 700,329 | 0 | 0 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 30,381 | 1,131,520 | SH | DFND | 2 | 952,003 | 0 | 179,517 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 1,163 | 43,309 | SH | DFND | 3 | 30,009 | 0 | 13,300 | |
| Lyft Inc Class A Common | CL A COM | 55087P104 | 49,719 | 1,851,738 | SH | SOLE | 0 | 1,851,738 | 0 | 0 | |
| M&T Bank | COM | 55261F104 | 8,748 | 84,580 | SH | DFND | 2 | 84,580 | 0 | 0 | |
| MRC Global | COM | 55345K103 | 2,769 | 650,000 | SH | SOLE | 0 | 650,000 | 0 | 0 | |
| MakeMyTrip | SHS | V5633W109 | 43,006 | 3,597,299 | SH | DFND | 2 | 2,508,953 | 0 | 1,088,346 | |
| Markel Corp | COM | 570535104 | 234,643 | 252,878 | SH | DFND | 2 | 237,239 | 0 | 15,639 | |
| Markel Corp | COM | 570535104 | 89,459 | 96,411 | SH | DFND | 1 | 96,411 | 0 | 0 | |
| Markel Corp | COM | 570535104 | 39,032 | 42,065 | SH | DFND | 3 | 28,596 | 0 | 13,469 | |
| Markel Corp | COM | 570535104 | 138,510 | 149,274 | SH | SOLE | 0 | 139,430 | 0 | 9,844 | |
| MarketAxess Holdings | COM | 57060D108 | 267,683 | 804,892 | SH | DFND | 1 | 804,892 | 0 | 0 | |
| MarketAxess Holdings | COM | 57060D108 | 297,323 | 894,015 | SH | DFND | 2 | 801,289 | 0 | 92,726 | |
| MarketAxess Holdings | COM | 57060D108 | 31,170 | 93,724 | SH | DFND | 3 | 83,030 | 0 | 10,694 | |
| MarketAxess Holdings | COM | 57060D108 | 104,417 | 313,971 | SH | SOLE | 0 | 313,971 | 0 | 0 | |
| Martin Marietta Materials | COM | 573284106 | 66,828 | 353,157 | SH | DFND | 1 | 353,157 | 0 | 0 | |
| Martin Marietta Materials | COM | 573284106 | 165,457 | 874,369 | SH | SOLE | 0 | 812,991 | 0 | 61,378 | |
| Martin Marietta Materials | COM | 573284106 | 45,843 | 242,259 | SH | DFND | 3 | 165,006 | 0 | 77,253 | |
| Martin Marietta Materials | COM | 573284106 | 240,196 | 1,269,334 | SH | DFND | 2 | 1,172,777 | 0 | 96,557 | |
| Masimo Corp | COM | 574795100 | 78 | 438 | SH | DFND | 3 | 438 | 0 | 0 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 664,524 | 2,750,967 | SH | DFND | 2 | 2,600,266 | 0 | 150,701 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 97,030 | 401,682 | SH | DFND | 3 | 274,112 | 0 | 127,570 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 291,195 | 1,205,476 | SH | DFND | 1 | 1,205,476 | 0 | 0 | |
| Mastercard Inc-Class A | CL A | 57636Q104 | 365,557 | 1,513,316 | SH | SOLE | 0 | 1,416,102 | 0 | 97,214 | |
| McDonald's | COM | 580135101 | 15 | 92 | SH | DFND | 3 | 92 | 0 | 0 | |
| McDonald's | COM | 580135101 | 715 | 4,322 | SH | DFND | 2 | 0 | 0 | 4,322 | |
| McDonald's | COM | 580135101 | 11,992 | 72,527 | SH | DFND | 1 | 72,527 | 0 | 0 | |
| McDonald's | COM | 580135101 | 14,625 | 88,451 | SH | SOLE | 0 | 88,451 | 0 | 0 | |
| Menlo Therapeutics Inc | COM | 586858102 | 172 | 64,097 | SH | DFND | 1 | 64,097 | 0 | 0 | |
| Menlo Therapeutics Inc | COM | 586858102 | 177 | 65,874 | SH | SOLE | 0 | 65,874 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 14,162 | 28,986 | SH | DFND | 3 | 28,986 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 2,017,407 | 4,129,123 | SH | DFND | 2 | 3,297,932 | 0 | 831,191 | |
| MercadoLibre | COM | 58733R102 | 89,289 | 182,752 | SH | DFND | 1 | 182,752 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 4,632 | 9,480 | SH | DFND | 4 | 9,480 | 0 | 0 | |
| MercadoLibre | COM | 58733R102 | 148,813 | 304,582 | SH | SOLE | 0 | 304,582 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 37,644 | 54,516 | SH | DFND | 1 | 54,516 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 344,181 | 498,445 | SH | DFND | 2 | 350,194 | 0 | 148,251 | |
| Mettler-Toledo | COM | 592688105 | 1,440 | 2,085 | SH | DFND | 3 | 2,085 | 0 | 0 | |
| Mettler-Toledo | COM | 592688105 | 20,523 | 29,721 | SH | SOLE | 0 | 29,721 | 0 | 0 | |
| Microsoft | COM | 594918104 | 93,016 | 589,791 | SH | DFND | 3 | 399,428 | 0 | 190,363 | |
| Microsoft | COM | 594918104 | 529,748 | 3,359,003 | SH | DFND | 2 | 3,116,999 | 0 | 242,004 | |
| Microsoft | COM | 594918104 | 153,411 | 972,743 | SH | DFND | 1 | 972,743 | 0 | 0 | |
| Microsoft | COM | 594918104 | 345,131 | 2,188,390 | SH | SOLE | 0 | 2,038,079 | 0 | 150,311 | |
| Mobile Telesystems ADR | SPONSORED ADR | 607409109 | 195 | 25,700 | SH | DFND | 1 | 25,700 | 0 | 0 | |
| Moderna Inc | COM | 60770K107 | 48,202 | 1,609,414 | SH | DFND | 1 | 1,609,414 | 0 | 0 | |
| Moderna Inc | COM | 60770K107 | 42,958 | 1,434,312 | SH | DFND | 2 | 1,387,665 | 0 | 46,647 | |
| Moderna Inc | COM | 60770K107 | 3,588 | 119,812 | SH | DFND | 3 | 119,812 | 0 | 0 | |
| Moderna Inc | COM | 60770K107 | 11,871 | 396,346 | SH | SOLE | 0 | 396,346 | 0 | 0 | |
| Moody's Corp | COM | 615369105 | 153,531 | 725,917 | SH | DFND | 1 | 725,917 | 0 | 0 | |
| Moody's Corp | COM | 615369105 | 565,864 | 2,675,481 | SH | DFND | 2 | 2,475,502 | 0 | 199,979 | |
| Moody's Corp | COM | 615369105 | 365,180 | 1,726,618 | SH | SOLE | 0 | 1,596,923 | 0 | 129,695 | |
| Moody's Corp | COM | 615369105 | 106,694 | 504,463 | SH | DFND | 3 | 342,221 | 0 | 162,242 | |
| Myriad Genetics Inc | COM | 62855J104 | 17,243 | 1,204,954 | SH | DFND | 1 | 1,204,954 | 0 | 0 | |
| Myriad Genetics Inc | COM | 62855J104 | 12,084 | 844,452 | SH | DFND | 3 | 574,110 | 0 | 270,342 | |
| Myriad Genetics Inc | COM | 62855J104 | 59,140 | 4,132,799 | SH | DFND | 2 | 3,807,125 | 0 | 325,674 | |
| Myriad Genetics Inc | COM | 62855J104 | 39,893 | 2,787,801 | SH | SOLE | 0 | 2,578,640 | 0 | 209,161 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 6,380 | 2,294,797 | SH | DFND | 3 | 1,453,571 | 0 | 841,226 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 174,036 | 62,602,940 | SH | DFND | 2 | 38,058,413 | 0 | 24,544,527 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 12,570 | 4,521,662 | SH | DFND | 1 | 4,521,662 | 0 | 0 | |
| NIO Inc ADR | SPON ADS | 62914V106 | 89,863 | 32,324,732 | SH | SOLE | 0 | 27,610,423 | 0 | 4,714,309 | |
| NVIDIA | COM | 67066G104 | 79,613 | 302,022 | SH | DFND | 3 | 195,954 | 0 | 106,068 | |
| NVIDIA | COM | 67066G104 | 1,114,752 | 4,228,952 | SH | DFND | 2 | 1,715,249 | 0 | 2,513,703 | |
| NVIDIA | COM | 67066G104 | 205,342 | 778,990 | SH | DFND | 1 | 778,990 | 0 | 0 | |
| NVIDIA | COM | 67066G104 | 566,600 | 2,149,468 | SH | SOLE | 0 | 1,569,433 | 0 | 580,035 | |
| National Instruments Corp | COM | 636518102 | 10,531 | 318,357 | SH | DFND | 1 | 318,357 | 0 | 0 | |
| National Instruments Corp | COM | 636518102 | 5,276 | 159,494 | SH | DFND | 2 | 65,308 | 0 | 94,186 | |
| National Instruments Corp | COM | 636518102 | 1,702 | 51,441 | SH | DFND | 3 | 51,441 | 0 | 0 | |
| National Instruments Corp | COM | 636518102 | 12,208 | 369,048 | SH | SOLE | 0 | 369,048 | 0 | 0 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 69,471 | 216,449 | SH | DFND | 1 | 216,449 | 0 | 0 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 445,133 | 1,386,880 | SH | DFND | 2 | 481,599 | 0 | 905,281 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 33,541 | 104,503 | SH | DFND | 3 | 66,645 | 0 | 37,858 | |
| NetEase.com ADR | SPONSORED ADR | 64110W102 | 144,143 | 449,100 | SH | SOLE | 0 | 230,374 | 0 | 218,726 | |
| Netflix Inc | COM | 64110L106 | 462,995 | 1,233,010 | SH | DFND | 1 | 1,233,010 | 0 | 0 | |
| Netflix Inc | COM | 64110L106 | 1,537,472 | 4,094,467 | SH | DFND | 2 | 2,188,181 | 0 | 1,906,286 | |
| Netflix Inc | COM | 64110L106 | 884,138 | 2,354,562 | SH | SOLE | 0 | 1,886,510 | 0 | 468,052 | |
| Netflix Inc | COM | 64110L106 | 124,013 | 330,261 | SH | DFND | 3 | 218,944 | 0 | 111,317 | |
| New Relic | COM | 64829B100 | 369 | 7,981 | SH | DFND | 3 | 7,981 | 0 | 0 | |
| New Relic | COM | 64829B100 | 25,318 | 547,542 | SH | DFND | 2 | 547,542 | 0 | 0 | |
| New Relic | COM | 64829B100 | 25,177 | 544,490 | SH | DFND | 1 | 544,490 | 0 | 0 | |
| New Relic | COM | 64829B100 | 8,221 | 177,799 | SH | SOLE | 0 | 177,799 | 0 | 0 | |
| Novocure Ltd | ORD SHS | G6674U108 | 30,204 | 448,532 | SH | DFND | 3 | 353,724 | 0 | 94,808 | |
| Novocure Ltd | ORD SHS | G6674U108 | 226,422 | 3,362,375 | SH | DFND | 2 | 3,039,794 | 0 | 322,581 | |
| Novocure Ltd | ORD SHS | G6674U108 | 148,677 | 2,207,860 | SH | DFND | 1 | 2,207,860 | 0 | 0 | |
| Novocure Ltd | ORD SHS | G6674U108 | 115,680 | 1,717,851 | SH | SOLE | 0 | 1,641,220 | 0 | 76,631 | |
| Now Inc/DE | COM | 67011P100 | 6,295 | 1,219,984 | SH | DFND | 1 | 1,219,984 | 0 | 0 | |
| Now Inc/DE | COM | 67011P100 | 24,538 | 4,755,434 | SH | DFND | 2 | 4,410,086 | 0 | 345,348 | |
| Now Inc/DE | COM | 67011P100 | 4,260 | 825,613 | SH | DFND | 3 | 574,013 | 0 | 251,600 | |
| Now Inc/DE | COM | 67011P100 | 18,329 | 3,552,123 | SH | SOLE | 0 | 3,333,795 | 0 | 218,328 | |
| Nucana Plc ADR | SPONSORED ADR | 67022C106 | 1,959 | 336,100 | SH | SOLE | 0 | 336,100 | 0 | 0 | |
| Nucana Plc ADR | SPONSORED ADR | 67022C106 | 2,864 | 491,208 | SH | DFND | 1 | 491,208 | 0 | 0 | |
| Nuveen Senior Income Fund | COM | 67067Y104 | 1,658 | 375,012 | SH | DFND | 1 | 375,012 | 0 | 0 | |
| Orchard Therapeutics PLC ADR | ADS | 68570P101 | 20,632 | 2,740,000 | SH | SOLE | 0 | 2,740,000 | 0 | 0 | |
| Pacira BioSciences | COM | 695127100 | 13,913 | 414,932 | SH | DFND | 2 | 195,955 | 0 | 218,977 | |
| Pacira BioSciences | COM | 695127100 | 16,213 | 483,526 | SH | DFND | 1 | 483,526 | 0 | 0 | |
| Pacira BioSciences | COM | 695127100 | 6,564 | 195,779 | SH | DFND | 3 | 172,297 | 0 | 23,482 | |
| Pacira BioSciences | COM | 695127100 | 10,651 | 317,655 | SH | SOLE | 0 | 317,655 | 0 | 0 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 43,778 | 1,648,892 | SH | DFND | 1 | 1,648,892 | 0 | 0 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 299,501 | 11,280,627 | SH | DFND | 2 | 3,972,129 | 0 | 7,308,498 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 96,801 | 3,645,980 | SH | SOLE | 0 | 1,800,105 | 0 | 1,845,875 | |
| Peloton Interactive Inc | CL A COM | 70614W100 | 23,628 | 889,960 | SH | DFND | 3 | 571,945 | 0 | 318,015 | |
| Penumbra Inc | COM | 70975L107 | 67,430 | 417,965 | SH | DFND | 1 | 417,965 | 0 | 0 | |
| Penumbra Inc | COM | 70975L107 | 1,131 | 7,012 | SH | DFND | 3 | 7,012 | 0 | 0 | |
| Penumbra Inc | COM | 70975L107 | 65,441 | 405,637 | SH | DFND | 2 | 405,637 | 0 | 0 | |
| Penumbra Inc | COM | 70975L107 | 20,667 | 128,106 | SH | SOLE | 0 | 128,106 | 0 | 0 | |
| Pepsico | COM | 713448108 | 1,126 | 9,378 | SH | DFND | 2 | 0 | 0 | 9,378 | |
| Pepsico | COM | 713448108 | 19,200 | 159,865 | SH | DFND | 1 | 159,865 | 0 | 0 | |
| Pepsico | COM | 713448108 | 26 | 213 | SH | DFND | 3 | 213 | 0 | 0 | |
| Pepsico | COM | 713448108 | 23,933 | 199,279 | SH | SOLE | 0 | 199,279 | 0 | 0 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 27,999 | 5,090,714 | SH | DFND | 1 | 5,090,714 | 0 | 0 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 146,109 | 26,565,354 | SH | DFND | 2 | 10,001,143 | 0 | 16,564,211 | |
| Petrobras Common ADR | SPONSORED ADR | 71654V408 | 4,101 | 745,563 | SH | SOLE | 0 | 745,563 | 0 | 0 | |
| Petrobras Pref ADR | SP ADR NON VTG | 71654V101 | 3,456 | 641,229 | SH | DFND | 1 | 641,229 | 0 | 0 | |
| Petrobras Pref ADR | SP ADR NON VTG | 71654V101 | 23,202 | 4,304,608 | SH | DFND | 2 | 1,938,764 | 0 | 2,365,844 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 84,054 | 2,332,879 | SH | DFND | 1 | 2,332,879 | 0 | 0 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 587,801 | 16,314,222 | SH | DFND | 2 | 5,667,956 | 0 | 10,646,266 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 265,520 | 7,369,405 | SH | SOLE | 0 | 4,812,433 | 0 | 2,556,972 | |
| Pinduoduo Inc ADR | SPONSORED ADS | 722304102 | 44,632 | 1,238,732 | SH | DFND | 3 | 794,514 | 0 | 444,218 | |
| Pioneer Floating Rate Trust | COM | 72369J102 | 4,120 | 538,606 | SH | DFND | 1 | 538,606 | 0 | 0 | |
| Procter & Gamble | COM | 742718109 | 23,293 | 211,751 | SH | DFND | 1 | 211,751 | 0 | 0 | |
| Procter & Gamble | COM | 742718109 | 31 | 280 | SH | DFND | 3 | 280 | 0 | 0 | |
| Procter & Gamble | COM | 742718109 | 1,374 | 12,492 | SH | DFND | 2 | 0 | 0 | 12,492 | |
| Procter & Gamble | COM | 742718109 | 28,755 | 261,412 | SH | SOLE | 0 | 261,412 | 0 | 0 | |
| Redfin | COM | 75737F108 | 2,637 | 171,010 | SH | DFND | 3 | 124,321 | 0 | 46,689 | |
| Redfin | COM | 75737F108 | 50,466 | 3,272,795 | SH | DFND | 2 | 3,272,795 | 0 | 0 | |
| Redfin | COM | 75737F108 | 52,530 | 3,406,634 | SH | DFND | 1 | 3,406,634 | 0 | 0 | |
| Redfin | COM | 75737F108 | 16,834 | 1,091,692 | SH | SOLE | 0 | 1,091,692 | 0 | 0 | |
| ResMed | COM | 761152107 | 86,089 | 584,483 | SH | DFND | 1 | 584,483 | 0 | 0 | |
| ResMed | COM | 761152107 | 209,715 | 1,423,823 | SH | SOLE | 0 | 1,320,196 | 0 | 103,627 | |
| ResMed | COM | 761152107 | 310,628 | 2,108,953 | SH | DFND | 2 | 1,945,854 | 0 | 163,099 | |
| ResMed | COM | 761152107 | 60,814 | 412,887 | SH | DFND | 3 | 280,279 | 0 | 132,608 | |
| ResTORbio Inc | COM | 76133L103 | 674 | 654,147 | SH | DFND | 1 | 654,147 | 0 | 0 | |
| ResTORbio Inc | COM | 76133L103 | 636 | 617,240 | SH | SOLE | 0 | 617,240 | 0 | 0 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 21,049 | 615,832 | SH | DFND | 3 | 415,692 | 0 | 200,140 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 173,684 | 5,081,439 | SH | DFND | 2 | 4,398,250 | 0 | 683,189 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 30,475 | 891,597 | SH | DFND | 1 | 891,597 | 0 | 0 | |
| Ritchie Bros Auctioneers (USA) | COM | 767744105 | 71,257 | 2,084,756 | SH | SOLE | 0 | 1,929,026 | 0 | 155,730 | |
| Ritchie Bros. Auctioneers | COM | 767744105 | 42,749 | 1,262,381 | SH | DFND | 2 | 707,277 | 0 | 555,104 | |
| Ritchie Bros. Auctioneers | COM | 767744105 | 14,695 | 433,928 | SH | SOLE | 0 | 433,928 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 87,410 | 999,202 | SH | DFND | 1 | 999,202 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 88,474 | 1,011,364 | SH | DFND | 2 | 1,011,364 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 1,231 | 14,067 | SH | DFND | 3 | 14,067 | 0 | 0 | |
| Roku | COM CL A | 77543R102 | 27,295 | 312,017 | SH | SOLE | 0 | 312,017 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 2,006 | 450,800 | SH | DFND | 1 | 450,800 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 15,929 | 3,579,565 | SH | SOLE | 0 | 3,579,565 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 250 | 56,095 | SH | DFND | 3 | 56,095 | 0 | 0 | |
| Rubius Therapeutics Inc | COM | 78116T103 | 758 | 170,440 | SH | DFND | 2 | 75,393 | 0 | 95,047 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 394,289 | 7,426,810 | SH | DFND | 2 | 5,776,923 | 0 | 1,649,887 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 2,816 | 53,049 | SH | DFND | 3 | 5,983 | 0 | 47,066 | |
| Ryanair ADR | SPONSORED ADR NE | 783513203 | 2,666 | 50,222 | SH | SOLE | 0 | 50,222 | 0 | 0 | |
| SEA Ltd ADR | ADR | 81141R100 | 71,315 | 1,609,457 | SH | DFND | 1 | 1,609,457 | 0 | 0 | |
| SEA Ltd ADR | ADR | 81141R100 | 163,024 | 3,679,164 | SH | DFND | 2 | 2,656,470 | 0 | 1,022,694 | |
| SEA Ltd ADR | ADR | 81141R100 | 26,296 | 593,462 | SH | DFND | 3 | 404,878 | 0 | 188,584 | |
| SEA Ltd ADR | ADR | 81141R100 | 112,055 | 2,528,889 | SH | SOLE | 0 | 2,379,770 | 0 | 149,119 | |
| SINA Corp | ORD | G81477104 | 4,189 | 131,550 | SH | DFND | 3 | 0 | 0 | 131,550 | |
| SUNPOWER CORP | DBCV 4.000 1/1 | 867652AL3 | 4,246 | 5,343,000 | SH | DFND | 1 | 5,343,000 | 0 | 0 | |
| SUNPOWER CORP | DBCV 4.000 1/1 | 867652AL3 | 649 | 817,000 | SH | DFND | 3 | 817,000 | 0 | 0 | |
| Sage Therapeutics Inc | COM | 78667J108 | 25 | 879 | SH | DFND | 3 | 879 | 0 | 0 | |
| Salesforce.com | COM | 79466L302 | 160,627 | 1,115,622 | SH | SOLE | 0 | 574,682 | 0 | 540,940 | |
| Salesforce.com | COM | 79466L302 | 501,837 | 3,485,465 | SH | DFND | 2 | 1,231,534 | 0 | 2,253,931 | |
| Salesforce.com | COM | 79466L302 | 37,903 | 263,253 | SH | DFND | 3 | 169,912 | 0 | 93,341 | |
| Salesforce.com | COM | 79466L302 | 71,848 | 499,012 | SH | DFND | 1 | 499,012 | 0 | 0 | |
| Schlumberger | COM | 806857108 | 1,342 | 99,477 | SH | DFND | 2 | 99,477 | 0 | 0 | |
| Seattle Genetics | COM | 812578102 | 152,165 | 1,318,815 | SH | SOLE | 0 | 1,228,740 | 0 | 90,075 | |
| Seattle Genetics | COM | 812578102 | 225,091 | 1,950,870 | SH | DFND | 2 | 1,749,519 | 0 | 201,351 | |
| Seattle Genetics | COM | 812578102 | 45,897 | 397,794 | SH | DFND | 3 | 282,293 | 0 | 115,501 | |
| Seattle Genetics | COM | 812578102 | 70,766 | 613,331 | SH | DFND | 1 | 613,331 | 0 | 0 | |
| Service Corp.Intl. | COM | 817565104 | 39,749 | 1,016,344 | SH | DFND | 3 | 688,189 | 0 | 328,155 | |
| Service Corp.Intl. | COM | 817565104 | 57,354 | 1,466,479 | SH | DFND | 1 | 1,466,479 | 0 | 0 | |
| Service Corp.Intl. | COM | 817565104 | 137,478 | 3,515,158 | SH | SOLE | 0 | 3,254,610 | 0 | 260,548 | |
| Service Corp.Intl. | COM | 817565104 | 202,632 | 5,181,075 | SH | DFND | 2 | 4,774,711 | 0 | 406,364 | |
| Severstal GDR Reg S | COM | 818150302 | 114 | 10,286 | SH | DFND | 1 | 10,286 | 0 | 0 | |
| Sherwin-Williams Co | COM | 824348106 | 8,767 | 19,079 | SH | DFND | 2 | 19,079 | 0 | 0 | |
| ShockWave Medical Inc | COM | 82489T104 | 30 | 891 | SH | DFND | 3 | 891 | 0 | 0 | |
| Shopify 'A' | CL A | 82509L107 | 541,924 | 1,299,795 | SH | SOLE | 0 | 1,069,475 | 0 | 230,320 | |
| Shopify 'A' | CL A | 82509L107 | 103,462 | 248,152 | SH | DFND | 3 | 169,010 | 0 | 79,142 | |
| Shopify 'A' | CL A | 82509L107 | 1,399,308 | 3,356,218 | SH | DFND | 2 | 2,387,087 | 0 | 969,131 | |
| Shopify 'A' | CL A | 82509L107 | 466,877 | 1,119,797 | SH | DFND | 1 | 1,119,797 | 0 | 0 | |
| SiteOne Landscape Supply | COM | 82982L103 | 25,428 | 345,391 | SH | DFND | 3 | 235,818 | 0 | 109,573 | |
| SiteOne Landscape Supply | COM | 82982L103 | 129,212 | 1,755,125 | SH | DFND | 2 | 1,617,519 | 0 | 137,606 | |
| SiteOne Landscape Supply | COM | 82982L103 | 87,778 | 1,192,313 | SH | SOLE | 0 | 1,104,276 | 0 | 88,037 | |
| SiteOne Landscape Supply | COM | 82982L103 | 36,755 | 499,256 | SH | DFND | 1 | 499,256 | 0 | 0 | |
| Slack Technologies Inc | COM CL A | 83088V102 | 28,169 | 1,049,526 | SH | SOLE | 0 | 1,049,526 | 0 | 0 | |
| Snap Inc | CL A | 83304A106 | 2,202 | 185,160 | SH | DFND | 2 | 185,160 | 0 | 0 | |
| Sohu.com | COM | 83410S108 | 1,247 | 200,140 | SH | DFND | 3 | 0 | 0 | 200,140 | |
| Splunk Inc | COM | 848637104 | 9,326 | 73,884 | SH | SOLE | 0 | 73,884 | 0 | 0 | |
| Splunk Inc | COM | 848637104 | 5,924 | 46,930 | SH | DFND | 3 | 46,930 | 0 | 0 | |
| Splunk Inc | COM | 848637104 | 17,232 | 136,509 | SH | DFND | 2 | 60,442 | 0 | 76,067 | |
| Splunk Inc | COM | 848637104 | 12,742 | 100,940 | SH | DFND | 1 | 100,940 | 0 | 0 | |
| Spotify Technology SA | SHS | L8681T102 | 54,354 | 447,583 | SH | DFND | 3 | 296,739 | 0 | 150,844 | |
| Spotify Technology SA | SHS | L8681T102 | 1,973,994 | 16,254,889 | SH | DFND | 2 | 11,138,153 | 0 | 5,116,736 | |
| Spotify Technology SA | SHS | L8681T102 | 461,607 | 3,801,113 | SH | SOLE | 0 | 3,168,049 | 0 | 633,064 | |
| Spotify Technology SA | SHS | L8681T102 | 142,550 | 1,173,830 | SH | DFND | 1 | 1,173,830 | 0 | 0 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 8,119 | 251,689 | SH | DFND | 3 | 223,046 | 0 | 28,643 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 24,114 | 747,490 | SH | DFND | 1 | 747,490 | 0 | 0 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 13,863 | 429,720 | SH | SOLE | 0 | 429,720 | 0 | 0 | |
| Staar Surgical | COM PAR $0.01 | 852312305 | 17,408 | 539,617 | SH | DFND | 2 | 254,875 | 0 | 284,742 | |
| Stericycle Inc | COM | 858912108 | 21,711 | 446,911 | SH | DFND | 3 | 297,971 | 0 | 148,940 | |
| Stericycle Inc | COM | 858912108 | 77,029 | 1,585,603 | SH | SOLE | 0 | 1,466,653 | 0 | 118,950 | |
| Stericycle Inc | COM | 858912108 | 31,465 | 647,697 | SH | DFND | 1 | 647,697 | 0 | 0 | |
| Stericycle Inc | COM | 858912108 | 110,846 | 2,281,727 | SH | DFND | 2 | 2,103,781 | 0 | 177,946 | |
| Stitch Fix | COM CL A | 860897107 | 25,707 | 2,024,184 | SH | DFND | 1 | 2,024,184 | 0 | 0 | |
| Stitch Fix | COM CL A | 860897107 | 25,077 | 1,974,585 | SH | DFND | 2 | 1,974,585 | 0 | 0 | |
| Stitch Fix | COM CL A | 860897107 | 357 | 28,128 | SH | DFND | 3 | 28,128 | 0 | 0 | |
| Stitch Fix | COM CL A | 860897107 | 8,073 | 635,685 | SH | SOLE | 0 | 635,685 | 0 | 0 | |
| StoneCo | COM CL A | G85158106 | 2,351 | 108,000 | SH | DFND | 2 | 108,000 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 1,944 | 121,857 | SH | DFND | 3 | 121,857 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 2,306 | 144,600 | SH | SOLE | 0 | 144,600 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 3,609 | 226,300 | SH | DFND | 1 | 226,300 | 0 | 0 | |
| Stratasys | SHS | M85548101 | 5,897 | 369,732 | SH | DFND | 2 | 162,097 | 0 | 207,635 | |
| T. Rowe Price | COM | 74144T108 | 224 | 2,293 | SH | DFND | 2 | 0 | 0 | 2,293 | |
| T. Rowe Price | COM | 74144T108 | 4,764 | 48,787 | SH | DFND | 1 | 48,787 | 0 | 0 | |
| T. Rowe Price | COM | 74144T108 | 6 | 62 | SH | DFND | 3 | 62 | 0 | 0 | |
| T. Rowe Price | COM | 74144T108 | 5,755 | 58,930 | SH | SOLE | 0 | 58,930 | 0 | 0 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 96,889 | 1,819,161 | SH | DFND | 1 | 1,819,161 | 0 | 0 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 2,138,348 | 40,149,232 | SH | DFND | 2 | 29,646,841 | 0 | 10,502,391 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 215,152 | 4,039,661 | SH | SOLE | 0 | 2,084,868 | 0 | 1,954,793 | |
| TAL Education Group ADR | ADS REPSTG COM | 874080104 | 50,052 | 939,773 | SH | DFND | 3 | 602,780 | 0 | 336,993 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 30,544 | 881,258 | SH | DFND | 1 | 881,258 | 0 | 0 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 21,455 | 618,999 | SH | DFND | 3 | 421,626 | 0 | 197,373 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 107,301 | 3,095,808 | SH | DFND | 2 | 2,852,432 | 0 | 243,376 | |
| TD Ameritrade Holding Corp | COM | 87236Y108 | 73,336 | 2,115,881 | SH | SOLE | 0 | 1,961,922 | 0 | 153,959 | |
| TJX Companies | COM | 872540109 | 10,569 | 221,058 | SH | DFND | 1 | 221,058 | 0 | 0 | |
| TJX Companies | COM | 872540109 | 3,922 | 82,023 | SH | SOLE | 0 | 82,023 | 0 | 0 | |
| TJX Companies | COM | 872540109 | 1,552 | 32,468 | SH | DFND | 3 | 20,250 | 0 | 12,218 | |
| TJX Companies | COM | 872540109 | 17,441 | 364,806 | SH | DFND | 2 | 355,288 | 0 | 9,518 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 100,698 | 2,107,095 | SH | DFND | 1 | 2,107,095 | 0 | 0 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 833,577 | 17,442,492 | SH | DFND | 2 | 12,054,488 | 0 | 5,388,004 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 57,460 | 1,202,334 | SH | DFND | 3 | 825,678 | 0 | 376,656 | |
| TSMC ADR | SPONSORED ADR | 874039100 | 206,237 | 4,315,475 | SH | SOLE | 0 | 4,020,836 | 0 | 294,639 | |
| Tandem Diabetes Care | COM NEW | 875372203 | 14,485 | 225,100 | SH | DFND | 1 | 225,100 | 0 | 0 | |
| Tandem Diabetes Care | COM NEW | 875372203 | 13,488 | 209,600 | SH | SOLE | 0 | 209,600 | 0 | 0 | |
| Teladoc | COM | 87918A105 | 71,864 | 463,611 | SH | DFND | 3 | 363,605 | 0 | 100,006 | |
| Teladoc | COM | 87918A105 | 391,791 | 2,527,522 | SH | DFND | 2 | 2,201,350 | 0 | 326,172 | |
| Teladoc | COM | 87918A105 | 211,959 | 1,367,386 | SH | DFND | 1 | 1,367,386 | 0 | 0 | |
| Teladoc | COM | 87918A105 | 219,414 | 1,415,483 | SH | SOLE | 0 | 1,336,205 | 0 | 79,278 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 179,476 | 17,840,572 | SH | DFND | 2 | 11,871,833 | 0 | 5,968,739 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 4,741 | 471,279 | SH | DFND | 1 | 471,279 | 0 | 0 | |
| Tencent Music Entertainment ADR | SPONSORED ADS | 88034P109 | 19,608 | 1,949,121 | SH | SOLE | 0 | 1,949,121 | 0 | 0 | |
| Teradyne | COM | 880770102 | 250,349 | 4,621,543 | SH | DFND | 2 | 4,379,262 | 0 | 242,281 | |
| Teradyne | COM | 880770102 | 48,315 | 891,919 | SH | DFND | 1 | 891,919 | 0 | 0 | |
| Teradyne | COM | 880770102 | 33,161 | 612,158 | SH | DFND | 3 | 414,002 | 0 | 198,156 | |
| Teradyne | COM | 880770102 | 111,550 | 2,059,259 | SH | SOLE | 0 | 1,906,771 | 0 | 152,488 | |
| TerraForm Power | CL A COM | 88104R209 | 23,044 | 1,461,241 | SH | DFND | 1 | 1,461,241 | 0 | 0 | |
| TerraForm Power | CL A COM | 88104R209 | 34 | 2,150 | SH | DFND | 2 | 2,150 | 0 | 0 | |
| TerraForm Power | CL A COM | 88104R209 | 1,548 | 98,185 | SH | DFND | 3 | 98,185 | 0 | 0 | |
| Tesla Inc | COM | 88160R101 | 615,490 | 1,174,600 | SH | DFND | 1 | 1,174,600 | 0 | 0 | |
| Tesla Inc | COM | 88160R101 | 3,769,731 | 7,194,143 | SH | DFND | 2 | 4,919,719 | 0 | 2,274,424 | |
| Tesla Inc | COM | 88160R101 | 190,241 | 363,055 | SH | DFND | 3 | 252,272 | 0 | 110,783 | |
| Tesla Inc | COM | 88160R101 | 1,752,580 | 3,344,618 | SH | SOLE | 0 | 2,848,776 | 0 | 495,842 | |
| The Trade Desk | COM CL A | 88339J105 | 231,942 | 1,201,770 | SH | DFND | 2 | 1,161,238 | 0 | 40,532 | |
| The Trade Desk | COM CL A | 88339J105 | 166,600 | 863,215 | SH | DFND | 1 | 863,215 | 0 | 0 | |
| The Trade Desk | COM CL A | 88339J105 | 23,702 | 122,808 | SH | DFND | 3 | 85,919 | 0 | 36,889 | |
| The Trade Desk | COM CL A | 88339J105 | 111,156 | 575,939 | SH | SOLE | 0 | 550,241 | 0 | 25,698 | |
| Thermo Fisher Scientific | COM | 883556102 | 293,196 | 1,033,836 | SH | DFND | 2 | 955,594 | 0 | 78,242 | |
| Thermo Fisher Scientific | COM | 883556102 | 80,480 | 283,780 | SH | DFND | 1 | 283,780 | 0 | 0 | |
| Thermo Fisher Scientific | COM | 883556102 | 56,352 | 198,701 | SH | DFND | 3 | 134,821 | 0 | 63,880 | |
| Thermo Fisher Scientific | COM | 883556102 | 195,061 | 687,805 | SH | SOLE | 0 | 637,992 | 0 | 49,813 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 639,119 | 27,254,556 | SH | DFND | 2 | 18,855,899 | 0 | 8,398,657 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 60,806 | 2,592,988 | SH | DFND | 1 | 2,592,988 | 0 | 0 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 53,837 | 2,295,841 | SH | DFND | 3 | 938,460 | 0 | 1,357,381 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 222,200 | 9,475,488 | SH | SOLE | 0 | 7,871,527 | 0 | 1,603,961 | |
| Trip.com Group Sponsored ADR | AMERICAN DEP SHS | 89677Q107 | 1,124 | 47,913 | SH | DFND | 4 | 47,913 | 0 | 0 | |
| Trupanion | COM | 898202106 | 5,144 | 197,600 | SH | DFND | 1 | 197,600 | 0 | 0 | |
| Trupanion | COM | 898202106 | 2,990 | 114,860 | SH | DFND | 3 | 114,860 | 0 | 0 | |
| Trupanion | COM | 898202106 | 8,885 | 341,322 | SH | DFND | 2 | 151,517 | 0 | 189,805 | |
| Trupanion | COM | 898202106 | 19,132 | 735,000 | SH | SOLE | 0 | 735,000 | 0 | 0 | |
| United Parcel Service | CL B | 911312106 | 14,076 | 150,675 | SH | DFND | 1 | 150,675 | 0 | 0 | |
| United Parcel Service | CL B | 911312106 | 826 | 8,847 | SH | DFND | 2 | 0 | 0 | 8,847 | |
| United Parcel Service | CL B | 911312106 | 19 | 199 | SH | DFND | 3 | 199 | 0 | 0 | |
| United Parcel Service | CL B | 911312106 | 17,468 | 186,981 | SH | SOLE | 0 | 186,981 | 0 | 0 | |
| Unity Biotechnology Inc | COM | 91381U101 | 1,438 | 248,000 | SH | DFND | 1 | 248,000 | 0 | 0 | |
| Unity Biotechnology Inc | COM | 91381U101 | 20,619 | 3,555,014 | SH | SOLE | 0 | 3,555,014 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 3,058 | 474,100 | SH | DFND | 1 | 474,100 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 2,853 | 442,400 | SH | DFND | 2 | 195,900 | 0 | 246,500 | |
| Upwork Inc | COM | 91688F104 | 989 | 153,300 | SH | DFND | 3 | 153,300 | 0 | 0 | |
| Upwork Inc | COM | 91688F104 | 1,934 | 299,900 | SH | SOLE | 0 | 299,900 | 0 | 0 | |
| Uxin ADR | ADS | 91818X108 | 1,866 | 1,211,500 | SH | DFND | 1 | 1,211,500 | 0 | 0 | |
| Uxin ADR | ADS | 91818X108 | 869 | 564,600 | SH | SOLE | 0 | 564,600 | 0 | 0 | |
| Vale SA ADR | ADR | 91912E105 | 29,561 | 3,565,900 | SH | DFND | 1 | 3,565,900 | 0 | 0 | |
| Vale SA ADR | ADR | 91912E105 | 223,587 | 26,970,700 | SH | DFND | 2 | 11,304,500 | 0 | 15,666,200 | |
| Varian Medical Systems Inc | COM | 92220P105 | 6,674 | 65,009 | SH | DFND | 2 | 65,009 | 0 | 0 | |
| Veeco Instruments | COM | 922417100 | 5,616 | 586,854 | SH | DFND | 1 | 586,854 | 0 | 0 | |
| Veeco Instruments | COM | 922417100 | 4,780 | 499,501 | SH | DFND | 2 | 222,383 | 0 | 277,118 | |
| Veeco Instruments | COM | 922417100 | 1,661 | 173,580 | SH | DFND | 3 | 173,580 | 0 | 0 | |
| Verisk Analytics | COM | 92345Y106 | 9,225 | 66,186 | SH | DFND | 2 | 66,186 | 0 | 0 | |
| Vir Biotechnology Inc | COM | 92764N102 | 4,451 | 129,869 | SH | SOLE | 0 | 129,869 | 0 | 0 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 66,487 | 412,653 | SH | DFND | 1 | 412,653 | 0 | 0 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 231,599 | 1,437,432 | SH | DFND | 2 | 1,324,380 | 0 | 113,052 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 45,259 | 280,904 | SH | DFND | 3 | 190,944 | 0 | 89,960 | |
| Visa Inc-Class A Shares | COM CL A | 92826C839 | 156,004 | 968,250 | SH | SOLE | 0 | 896,928 | 0 | 71,322 | |
| Voya Prime Rate Trust | SH BEN INT | 92913A100 | 2,118 | 571,000 | SH | DFND | 1 | 571,000 | 0 | 0 | |
| Voya Prime Rate Trust | SH BEN INT | 92913A100 | 718 | 193,400 | SH | DFND | 3 | 193,400 | 0 | 0 | |
| WEC Energy Group | COM | 92939U106 | 857 | 9,720 | SH | DFND | 1 | 9,720 | 0 | 0 | |
| Wabtec | COM | 929740108 | 88,178 | 1,832,074 | SH | DFND | 2 | 1,703,634 | 0 | 128,440 | |
| Wabtec | COM | 929740108 | 16,284 | 338,336 | SH | DFND | 3 | 227,209 | 0 | 111,127 | |
| Wabtec | COM | 929740108 | 23,065 | 479,223 | SH | DFND | 1 | 479,223 | 0 | 0 | |
| Wabtec | COM | 929740108 | 54,964 | 1,141,999 | SH | SOLE | 0 | 1,057,151 | 0 | 84,848 | |
| Waters | COM | 941848103 | 57,046 | 313,351 | SH | DFND | 1 | 313,351 | 0 | 0 | |
| Waters | COM | 941848103 | 204,464 | 1,123,121 | SH | DFND | 2 | 1,039,777 | 0 | 83,344 | |
| Waters | COM | 941848103 | 39,765 | 218,431 | SH | DFND | 3 | 147,526 | 0 | 70,905 | |
| Waters | COM | 941848103 | 127,710 | 701,512 | SH | SOLE | 0 | 647,933 | 0 | 53,579 | |
| Watsco Inc | COM | 942622200 | 103,004 | 651,799 | SH | DFND | 2 | 647,290 | 0 | 4,509 | |
| Watsco Inc | COM | 942622200 | 102,044 | 645,727 | SH | DFND | 1 | 645,727 | 0 | 0 | |
| Watsco Inc | COM | 942622200 | 4,123 | 26,088 | SH | DFND | 3 | 19,234 | 0 | 6,854 | |
| Watsco Inc | COM | 942622200 | 44,335 | 280,548 | SH | SOLE | 0 | 280,548 | 0 | 0 | |
| Wayfair Inc Class A | CL A | 94419L101 | 113,325 | 2,120,606 | SH | DFND | 1 | 2,120,606 | 0 | 0 | |
| Wayfair Inc Class A | CL A | 94419L101 | 113,265 | 2,119,487 | SH | DFND | 2 | 1,970,381 | 0 | 149,106 | |
| Wayfair Inc Class A | CL A | 94419L101 | 8,089 | 151,360 | SH | DFND | 3 | 138,670 | 0 | 12,690 | |
| Wayfair Inc Class A | CL A | 94419L101 | 94,890 | 1,775,634 | SH | SOLE | 0 | 1,775,634 | 0 | 0 | |
| Wheaton Precious Metals | COM | 962879102 | 195 | 7,073 | SH | DFND | 1 | 7,073 | 0 | 0 | |
| Wipro Ltd ADR | SPON ADR 1 SH | 97651M109 | 433 | 139,630 | SH | DFND | 2 | 139,630 | 0 | 0 | |
| Wix Com | SHS | M98068105 | 377,818 | 3,747,447 | SH | DFND | 2 | 1,953,446 | 0 | 1,794,001 | |
| Workday Inc | CL A | 98138H101 | 148,372 | 1,139,397 | SH | DFND | 1 | 1,139,397 | 0 | 0 | |
| Workday Inc | CL A | 98138H101 | 483,272 | 3,711,195 | SH | DFND | 2 | 1,882,818 | 0 | 1,828,377 | |
| Workday Inc | CL A | 98138H101 | 28,926 | 222,129 | SH | DFND | 3 | 146,380 | 0 | 75,749 | |
| Workday Inc | CL A | 98138H101 | 258,244 | 1,983,139 | SH | SOLE | 0 | 1,543,607 | 0 | 439,532 | |
| Xylem | COM | 98419M100 | 10,222 | 156,954 | SH | DFND | 1 | 156,954 | 0 | 0 | |
| Xylem | COM | 98419M100 | 3,624 | 55,635 | SH | DFND | 3 | 55,635 | 0 | 0 | |
| Xylem | COM | 98419M100 | 6,707 | 102,971 | SH | DFND | 2 | 75,698 | 0 | 27,273 | |
| Yext Inc | COM | 98585N106 | 42,262 | 4,147,372 | SH | DFND | 1 | 4,147,372 | 0 | 0 | |
| Yext Inc | COM | 98585N106 | 18,058 | 1,772,093 | SH | SOLE | 0 | 1,772,093 | 0 | 0 | |
| Yext Inc | COM | 98585N106 | 5,981 | 586,971 | SH | DFND | 3 | 558,196 | 0 | 28,775 | |
| Yext Inc | COM | 98585N106 | 42,569 | 4,177,487 | SH | DFND | 2 | 3,415,303 | 0 | 762,184 | |
| Zai Lab ADR | ADR | 98887Q104 | 42,486 | 825,300 | SH | DFND | 1 | 825,300 | 0 | 0 | |
| Zai Lab ADR | ADR | 98887Q104 | 81,328 | 1,579,800 | SH | DFND | 2 | 785,500 | 0 | 794,300 | |
| Zai Lab ADR | ADR | 98887Q104 | 18,270 | 354,900 | SH | DFND | 3 | 135,500 | 0 | 219,400 | |
| Zai Lab ADR | ADR | 98887Q104 | 18,265 | 354,800 | SH | SOLE | 0 | 354,800 | 0 | 0 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 35,196 | 1,036,093 | SH | DFND | 1 | 1,036,093 | 0 | 0 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 60,222 | 1,772,796 | SH | DFND | 2 | 1,665,544 | 0 | 107,252 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 3,165 | 93,164 | SH | DFND | 3 | 69,194 | 0 | 23,970 | |
| Zillow Group Inc Class A | CL A | 98954M101 | 21,354 | 628,625 | SH | SOLE | 0 | 612,475 | 0 | 16,150 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 73,435 | 2,038,739 | SH | DFND | 1 | 2,038,739 | 0 | 0 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 175,930 | 4,884,223 | SH | DFND | 2 | 4,034,760 | 0 | 849,463 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 118,525 | 3,290,522 | SH | SOLE | 0 | 3,079,207 | 0 | 211,315 | |
| Zillow Group Inc Class C | CL C CAP STK | 98954M200 | 39,763 | 1,103,902 | SH | DFND | 3 | 838,191 | 0 | 265,711 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 178,878 | 1,224,187 | SH | DFND | 1 | 1,224,187 | 0 | 0 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 551,265 | 3,772,687 | SH | DFND | 2 | 1,782,519 | 0 | 1,990,168 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 37,226 | 254,765 | SH | DFND | 3 | 165,002 | 0 | 89,763 | |
| Zoom Video Communications Inc | CL A | 98980L101 | 280,243 | 1,917,899 | SH | SOLE | 0 | 1,446,525 | 0 | 471,374 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 3,898 | 484,179 | SH | DFND | 1 | 484,179 | 0 | 0 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 1,002 | 124,432 | SH | DFND | 3 | 124,432 | 0 | 0 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 2,880 | 357,766 | SH | DFND | 2 | 158,852 | 0 | 198,914 | |
| Zuora Inc Class A | COM CL A | 98983V106 | 1,975 | 245,311 | SH | SOLE | 0 | 245,311 | 0 | 0 | |
| iRobot | COM | 462726100 | 7,135 | 174,459 | SH | DFND | 1 | 174,459 | 0 | 0 | |
| iRobot | COM | 462726100 | 13,237 | 323,653 | SH | SOLE | 0 | 323,653 | 0 | 0 | |
| iRobot | COM | 462726100 | 4,256 | 104,052 | SH | DFND | 3 | 91,939 | 0 | 12,113 | |
| iRobot | COM | 462726100 | 9,043 | 221,110 | SH | DFND | 2 | 104,181 | 0 | 116,929 | |