The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 1,902 674,300 SH   SOLE 674,300 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 2,646 438,884 SH   SOLE 438,884 0 0
ADVAXIS INC COM NEW 007624307 300 350,000 SH   SOLE 350,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 6,474 267,839 SH   SOLE 267,839 0 0
AFFIMED NV COM N01045108 3,106 1,133,559 SH   SOLE 1,133,559 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 4,870 770,538 SH   SOLE 770,538 0 0
ALECTOR INC COM 014442107 2,498 145,000 SH   SOLE 145,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,245 40,657 SH   SOLE 40,657 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,624 359,190 SH   SOLE 359,190 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 1,890 173,914 SH   SOLE 173,914 0 0
ARDELYX INC COM 039697107 1,500 199,850 SH   SOLE 199,850 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,494 98,942 SH   SOLE 98,942 0 0
ARGENX SE SPONSORED ADR 04016X101 975 6,071 SH   SOLE 6,071 0 0
ARQULE INC COM 04269E107 9,935 497,762 SH   SOLE 497,762 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,909 28,100 SH   SOLE 28,100 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 239 117,682 SH   SOLE 117,682 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 728 35,573 SH   SOLE 35,573 0 0
ATRICURE INC COM 04963C209 10,362 318,729 SH   SOLE 318,729 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,320 100,000 SH   SOLE 100,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,773 514,051 SH   SOLE 514,051 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 4,067 74,700 SH   SOLE 74,700 0 0
BIOTELEMETRY INC COM 090672106 2,560 55,300 SH   SOLE 55,300 0 0
BLUEBIRD BIO INC COM 09609G100 2,238 25,500 SH   SOLE 25,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 9,871 123,218 SH   SOLE 123,218 0 0
CARA THERAPEUTICS INC COM 140755109 5,293 328,533 SH   SOLE 328,533 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 2,245 46,200 SH   SOLE 46,200 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,623 297,300 SH   SOLE 297,300 0 0
CYTOKINETICS INC COM NEW 23282W605 4,443 418,727 SH   SOLE 418,727 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 831 100,000 SH   SOLE 100,000 0 0
DEXCOM INC COM 252131107 7,949 36,338 SH   SOLE 36,338 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 556 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,606 118,314 SH   SOLE 118,314 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 1,515 205,825 SH   SOLE 205,825 0 0
EPIZYME INC COM 29428V104 1,673 68,000 SH   SOLE 68,000 0 0
EVELO BIOSCIENCES INC COM 299734103 44 10,726 SH   SOLE 10,726 0 0
EXICURE INC COM 30205M101 787 275,000 SH   SOLE 275,000 0 0
FATE THERAPEUTICS INC COM 31189P102 9,198 470,000 SH   SOLE 470,000 0 0
GALAPAGOS NV SPON ADR 36315X101 9,721 47,000 SH   SOLE 47,000 0 0
GAMIDA CELL LTD SHS M47364100 640 148,781 SH   SOLE 148,781 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,123 542,564 SH   SOLE 542,564 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 449 50,000 SH   SOLE 50,000 0 0
INOGEN INC COM 45780L104 1,572 23,000 SH   SOLE 23,000 0 0
INSMED INC COM PAR $.01 457669307 716 30,000 SH   SOLE 30,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 7,821 64,900 SH   SOLE 64,900 0 0
JOHNSON AND JOHNSON COM 478160104 1,371 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 1,696 374,423 SH   SOLE 374,423 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 440 24,725 SH   SOLE 24,725 0 0
KURA ONCOLOGY INC COM 50127T109 2,385 173,475 SH   SOLE 173,475 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 85 95,000 SH   SOLE 95,000 0 0
LUMINEX CORP COM 55027E102 4,727 204,091 SH   SOLE 204,091 0 0
MACROGENICS INC COM 556099109 1,632 150,000 SH   SOLE 150,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 1,239 13,600 SH   SOLE 13,600 0 0
MASIMO CORPORATION COM 574795100 474 3,000 SH   SOLE 3,000 0 0
MENLO THERAPEUTICS INC COM 586858102 3,701 797,565 SH   SOLE 797,565 0 0
MERSANA THERAPEUTICS INC COM 59045L106 621 108,463 SH   SOLE 108,463 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 873 129,525 SH   SOLE 129,525 0 0
MORPHIC HOLDING INC COM 61775R105 635 37,000 SH   SOLE 37,000 0 0
NATUS MEDICAL INC COM 639050103 1,415 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 6,558 61,008 SH   SOLE 61,008 0 0
NEURONETICS INC COM 64131A105 1,777 395,772 SH   SOLE 395,772 0 0
NEXTCURE INC COM 65343E108 1,127 20,000 SH   SOLE 20,000 0 0
OTONOMY INC COM 68906L105 1,797 469,135 SH   SOLE 469,135 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,203 360,542 SH   SOLE 360,542 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 1,187 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 11,040 1,114,000 SH   SOLE 1,114,000 0 0
RADIUS HEALTH INC COM NEW 750469207 444 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,395 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 337 157,700 SH   SOLE 157,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,010 124,806 SH   SOLE 124,806 0 0
SCYNEXIS INC COM 811292101 1,099 1,207,413 SH   SOLE 1,207,413 0 0
STEREOTAXIS INC COM NEW 85916J409 72,370 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 440 40,000 SH   SOLE 40,000 0 0
SYNLOGIC INC COM 87166L100 1,292 500,731 SH   SOLE 500,731 0 0
TRANSLATE BIO INC COM 89374L104 1,464 179,845 SH   SOLE 179,845 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,894 30,408 SH   SOLE 30,408 0 0
UROGEN PHARMA LTD COM M96088105 133 3,987 SH   SOLE 3,987 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,678 209,200 SH   SOLE 209,200 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 296 36,960 SH   SOLE 36,960 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,262 248,854 SH   SOLE 248,854 0 0
ZAFGEN INC COM 98885E103 339 305,500 SH   SOLE 305,500 0 0
ZOGENIX INC COM NEW 98978L204 5,565 106,749 SH   SOLE 106,749 0 0