The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AKERO THERAPEUTICS INC COM 00973Y108 16,438 740,621 SH   DFND 1 740,621 0 0
ALLAKOS INC COM 01671P100 28,608 300,000 SH   DFND 1 300,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 27,872 1,300,000 SH   DFND 1 1,300,000 0 0
ANAPTYSBIO INC COM 032724106 5,931 365,000 SH   DFND 1 365,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 82,674 2,700,000 SH   DFND 1 2,700,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 7,826 172,300 SH   DFND 1 172,300 0 0
ARGENX SE SPONSORED ADR 04016X101 16,052 100,000 SH   DFND 1 100,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 55,648 400,000 SH   DFND 1 400,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 34,780 250,000 SH Call DFND 1 250,000 0 0
ATRECA INC CL A COM 04965G109 5,045 326,141 SH   DFND 1 326,141 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 6,336 479,988 SH   DFND 1 479,988 0 0
AVROBIO INC COM 05455M100 6,393 317,579 SH   DFND 1 317,579 0 0
AXONICS MODULATION TECH INC COM 05465P101 33,880 1,222,671 SH   DFND 1 1,222,671 0 0
AXSOME THERAPEUTICS INC COM 05464T104 62,016 600,000 SH   DFND 1 600,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 54,440 1,000,000 SH   DFND 1 1,000,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 27,220 500,000 SH Call DFND 1 500,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 27,638 345,000 SH   DFND 1 345,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 88,076 2,512,865 SH   DFND 1 2,512,865 0 0
CABALETTA BIO INC COM 12674W109 29,604 2,119,132 SH   DFND 1 2,119,132 0 0
CHEMOCENTRYX INC COM 16383L106 114,695 2,900,000 SH   DFND 1 2,900,000 0 0
CHEMOCENTRYX INC COM 16383L106 9,888 250,000 SH Call DFND 1 250,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 108,353 2,300,000 SH   DFND 1 2,300,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 60,905 1,000,000 SH   DFND 1 1,000,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 28,008 450,000 SH   DFND 1 450,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 28,448 495,692 SH   DFND 1 495,692 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 12,418 833,400 SH   DFND 1 833,400 0 0
GALAPAGOS NV SPON ADR 36315X101 20,921 100,000 SH   DFND 1 100,000 0 0
GOSSAMER BIO INC COM 38341P102 4,689 300,000 SH   DFND 1 300,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 9,613 649,994 SH   DFND 1 649,994 0 0
IGM BIOSCIENCES INC COM 449585108 5,968 156,400 SH   DFND 1 156,400 0 0
IMMUNOVANT INC UNIT 12/18/2024 45258J201 26,548 1,080,000 SH   DFND 1 1,080,000 0 0
INSPIRE MED SYS INC COM 457730109 12,786 172,300 SH   DFND 1 172,300 0 0
KURA ONCOLOGY INC COM 50127T109 13,750 1,000,000 SH   DFND 1 1,000,000 0 0
MERUS N V COM N5749R100 14,080 1,000,000 SH   DFND 1 1,000,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,322 607,903 SH   DFND 1 607,903 0 0
MIRATI THERAPEUTICS INC COM 60468T105 165,249 1,282,392 SH   DFND 1 1,282,392 0 0
MIRATI THERAPEUTICS INC COM 60468T105 64,430 500,000 SH Call DFND 1 500,000 0 0
MYOKARDIA INC COM 62857M105 51,020 700,000 SH   DFND 1 700,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 31,040 2,000,000 SH   DFND 1 2,000,000 0 0
NEKTAR THERAPEUTICS COM 640268108 4,317 200,000 SH   DFND 1 200,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,224 39,300 SH   DFND 1 39,300 0 0
NEXTCURE INC COM 65343E108 56,330 1,000,000 SH   DFND 1 1,000,000 0 0
OMEROS CORP COM 682143102 21,487 1,525,000 SH   DFND 1 1,525,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,815 350,203 SH   DFND 1 350,203 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 27 416,666 SH   DFND 1 416,666 0 0
PRECISION BIOSCIENCES INC COM 74019P108 6,494 467,516 SH   DFND 1 467,512 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 109,063 1,990,922 SH   DFND 1 1,990,922 0 0
QUOTIENT LTD SHS G73268107 33,285 3,500,000 SH   DFND 1 3,500,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 13,873 295,600 SH   DFND 1 295,600 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 166,897 816,400 SH   DFND 1 816,400 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 51,108 250,000 SH Call DFND 1 250,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 41,816 1,837,269 SH   DFND 1 1,837,269 0 0
SAREPTA THERAPEUTICS INC COM 803607100 32,260 250,000 SH   DFND 1 250,000 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 16,893 858,382 SH   DFND 1 858,382 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 13,520 4,000,000 SH   DFND 1 4,000,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 47,555 500,000 SH Put DFND 1 500,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 50,654 1,788,643 SH   DFND 1 1,788,643 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 1,295 50,000 SH   DFND 1 50,000 0 0
TRICIDA INC COM 89610F101 35,022 927,975 SH   DFND 1 927,975 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 211,577 3,396,650 SH   DFND 1 3,396,650 0 0
TWIST BIOSCIENCE CORP COM 90184D100 14,430 687,149 SH   DFND 1 687,149 0 0
UNIQURE NV SHS N90064101 28,664 400,000 SH   DFND 1 400,000 0 0
VIELA BIO INC COM 926613100 40,657 1,497,500 SH   DFND 1 1,497,500 0 0
X4 PHARMACEUTICALS INC COM 98420X103 2,704 252,747 SH   DFND 1 252,747 0 0
Y-MABS THERAPEUTICS INC COM 984241109 50,074 1,602,376 SH   DFND 1 1,602,376 0 0
ZAI LAB LTD ADR 98887Q104 11,527 277,161 SH   DFND 1 277,161 0 0
ZYMEWORKS INC COM 98985W102 31,822 700,000 SH   DFND 1 700,000 0 0