The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 4,375 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
AC IMMUNE SA SHS H00263105 8,520 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 10,140 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ACCELERON PHARMA INC COM 00434H108 63,624 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 4,488 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ADURO BIOTECH INC COM 00739L101 1,180 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 2,292 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
AGENUS INC COM NEW 00847G705 10,175 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 28,650 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,686 425,000 SH   DFND 1,2,3,4,5,6 425,000 0 0
ALBIREO PHARMA INC COM 01345P106 11,444 450,200 SH   DFND 1,2,3,4,5,6 450,200 0 0
ALECTOR INC COM 014442107 3,877 225,000 SH   DFND 1,2,3,4,5,6 225,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 95,445 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 115,170 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 14,340 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 29,220 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 4,870 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
ARAVIVE INC COM 03890D108 18,455 1,350,000 SH   DFND 1,2,3,4,5,6 1,350,000 0 0
ARGENX SE SPONSORED ADR 04016X101 56,182 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 13,912 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 28,823 1,750,000 SH   DFND 1,2,3,4,5,6 1,750,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 6,600 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AVANTOR INC COM 05352A100 86,213 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
AXCELLA HEALTH INC COM 05454B105 1,805 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 106,086 640,000 SH   DFND 1,2,3,4,5,6 640,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,455 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 75,489 2,228,130 SH   DFND 1,2,3,4 2,228,130 0 0
BIONTECH SE SPONSORED ADS 09075V102 13,552 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
BLUEBIRD BIO INC COM 09609G100 8,775 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 32,044 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 8,011 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 7,010 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,425 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 7,819 750,000 SH Call DFND 1,2,3,4,5,6 750,000 0 0
CURIS INC COM NEW 231269200 2,550 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 3,673 1,350,531 SH   DFND 1,2,3,4,5,6 1,350,531 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 30 11,053 SH   DFND 1,2,3,4 11,053 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 15,560 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 6,968 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 11,015 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DOUYU INTERNATIONAL HLDNGS L SPONSORED ADS 25985W105 3,388 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
EPIZYME INC COM 29428V104 55,350 2,250,000 SH   DFND 1,2,3,4,5,6 2,250,000 0 0
FATE THERAPEUTICS INC COM 31189P102 39,140 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
FATE THERAPEUTICS INC COM 31189P102 3,914 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
FIBROGEN INC COM 31572Q808 17,156 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
GOSSAMER BIO INC COM 38341P102 25,148 1,608,968 SH   DFND 1,2,3,4,5,6 1,608,968 0 0
HARPOON THERAPEUTICS INC COM 41358P106 12,572 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
HOOKIPA PHARMA INC COM 43906K100 12,291 1,004,987 SH   DFND 1,2,3,4,5,6 1,004,987 0 0
IGM BIOSCIENCES INC COM 449585108 5,724 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
IMMUNIC INC COM 4525EP101 6,111 630,019 SH   DFND 1,2,3,4,5,6 630,019 0 0
INCYTE CORP COM 45337C102 8,732 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,930 199,700 SH   DFND 1,2,3,4,5,6 199,700 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 13,840 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,471 110,532 SH   DFND 1,2,3,4 110,532 0 0
KALEIDO BIOSCIENCES INC COM 483347100 2,513 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KARUNA THERAPEUTICS INC COM 48576A100 3,767 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
KRYSTAL BIOTECH INC COM 501147102 4,430 80,000 SH   DFND 1,2,3,4,5,6 80,000 0 0
KURA ONCOLOGY INC COM 50127T109 5,500 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 14,592 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 235,407 56,724,650 SH   DFND 1,2,3,4 61,045,868 0 0
LIONS GATE ENTMNT CORP CL A VTG 535919401 5,330 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MERUS N V COM N5749R100 7,040 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 7,110 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MODERNA INC COM 60770K107 90,099 4,606,298 SH   DFND 1,2,3,4,5,6 4,606,298 0 0
MODERNA INC COM 60770K107 9,780 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MORGAN STANLEY COM NEW 617446448 102,240 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
MORPHIC HLDG INC COM 61775R105 31,217 1,819,186 SH   DFND 1,2,3,4,5,6 1,319,186 0 0
NEKTAR THERAPEUTICS COM 640268108 10,793 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
NIO INC SPONSORED ADS 62914V106 7,035 1,750,000 SH Call DFND 1,2,3,4,5,6 1,750,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,813 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
PAYPAL HLDGS INC COM 70450Y103 21,634 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 12,883 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
PROTHENA CORP PLC SHS G72800108 4,749 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
THE REALREAL INC COM 88339P101 3,770 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 10,222 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
REGENXBIO INC COM 75901B107 5,941 145,000 SH   DFND 1,2,3,4,5,6 145,000 0 0
REPLIMUNE GROUP INC COM 76029N106 8,610 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 26,921 2,833,791 SH   DFND 1,2,3,4,5,6 2,833,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 10,829 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 3,390 405,000 SH   DFND 1,2,3,4,5,6 405,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 33,557 2,546,040 SH   DFND 1,2,3,4,5,6 2,546,040 0 0
SELECTA BIOSCIENCES INC COM 816212104 8,124 3,413,629 SH   DFND 1,2,3,4,5,6 3,413,629 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,010 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 4,808 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 13,472 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,827 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
STONECO LTD COM CL A G85158106 15,956 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 5,712 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TG THERAPEUTICS INC COM 88322Q108 7,215 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
TRANSLATE BIO INC COM 89374L104 5,291 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
TRICIDA INC COM 89610F101 13,586 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 18,687 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 2,100 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 14,870 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,807 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
WW INTL INC COM 98262P101 566,207 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
XENCOR INC COM 98401F105 18,915 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
Y MABS THERAPEUTICS INC COM 984241109 12,500 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 34,455 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0