The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 37,006 209,760 SH   DFND 1 209,760 0 0
ABBVIE INC COM 00287Y109 216 2,440 SH   DFND 1 2,440 0 0
ADVANCED ENERGY INDUSTRIES INC COM 007973100 260 3,650 SH   DFND 1 3,650 0 0
AKARI THERAPEUTICS PLC COM 00972G108 2,625 1,500,096 SH   DFND 1 1,500,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 465 80,020 SH   DFND 1 80,020 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 37,412 195,700 SH   DFND 1 195,700 0 0
ALLISON TRANSMISSION HOLDINGS INC COM 01973R101 206 4,270 SH   DFND 1 4,270 0 0
ALPHABET INC CLASS C CL C 38259P706 8,102 6,060 SH   DFND 1 0 0 6,060
ALPINE IMMUNE SCIENCES INC COM 02083G100 712 185,287 SH   DFND 1 185,287 0 0
ALTRIA GROUP INC COM 02209S103 13,873 277,960 SH   DFND 1 277,960 0 0
AMERISOURCEBERGEN CORP COM 03073E105 220 2,590 SH   DFND 1 2,590 0 0
AMGEN INC COM 031162100 8,112 33,650 SH   DFND 1 33,650 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,112 429,200 SH   DFND 1 429,200 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 7,687 93,700 SH   DFND 1 93,700 0 0
APPLIED MATERIALS INC COM 038222105 283 4,630 SH   DFND 1 4,630 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 16,070 319,290 SH   DFND 1 319,290 0 0
BECTON DICKINSON & CO COM 075887109 6,519 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 258,088 760 SH   DFND 1 760 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 612 2,700 SH   DFND 1 2,700 0 0
BHP BILLITON PLC COM 05545E209 10,621 225,930 SH   DFND 1 225,930 0 0
BIOGEN INC COM 09062X103 252 850 SH   DFND 1 850 0 0
BOEING CO COM 097023105 18,862 57,900 SH   DFND 1 57,900 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 919 21,650 SH   DFND 1 21,650 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 2,042 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 5,381 26,316 SH   DFND 1 26,316 0 0
CISCO SYSTEMS INC COM 17275R102 4,983 103,900 SH   DFND 1 103,900 0 0
COCA COLA CO COM 191216100 2,546 46,000 SH   DFND 1 46,000 0 0
CORCEPT THERAPEUTICS INC COM 218352102 203 16,790 SH   DFND 1 16,790 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 435 80,000 SH   DFND 1 80,000 0 0
DANAHER CORP COM 235851102 33,121 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 302 4,020 SH   DFND 1 4,020 0 0
DELUXE CORP COM 248019101 215 4,300 SH   DFND 1 4,300 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 8,053 271,680 SH   DFND 1 271,680 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 253 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 604 105,573 SH   DFND 1 105,573 0 0
ECOLAB INC COM 278865100 405 2,100 SH   DFND 1 2,100 0 0
EMCOR GROUP INC COM 29084Q100 222 2,570 SH   DFND 1 2,570 0 0
EXXON MOBIL CORPORATION COM 30231G102 13,450 192,750 SH   DFND 1 192,750 0 0
FACEBOOK INC CLASS A CL A 30303M102 205 1,000 SH   DFND 1 1,000 0 0
FIAT CHRYSLER AUTOMOBILES NV COM N31738102 490 33,350 SH   DFND 1 33,350 0 0
FORTIVE CORP COM 34959J108 11,038 144,500 SH   DFND 1 144,500 0 0
FTS INTERNATIONAL INC COM 30283W104 19 18,640 SH   DFND 1 18,640 0 0
GAMESTOP CORP-CLASS A CL A 36467W109 134 22,120 SH   DFND 1 22,120 0 0
GENERAL ELECTRIC COMPANY COM 369604103 561 50,280 SH   DFND 1 50,280 0 0
GENERAL MILLS INC COM 370334104 353 6,600 SH   DFND 1 6,600 0 0
GILEAD SCIENCES INC COM 375558103 1,407 21,650 SH   DFND 1 21,650 0 0
GRAFTECH INTERNATIONAL LTD COM 384313508 164 14,150 SH   DFND 1 14,150 0 0
HP INC COM 40434L105 201 9,790 SH   DFND 1 9,790 0 0
INNOVIVA INC COM 45781M101 203 14,340 SH   DFND 1 14,340 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 2,843 21,210 SH   DFND 1 21,210 0 0
INTUITIVE SURGICAL INC COM 46120E602 11,025 18,650 SH   DFND 1 18,650 0 0
ISHARES CORE HIGH DIVIDEND ETF ETF 46429B663 3,341 34,070 SH   DFND 1 34,070 0 0
ISHARES MSCI RUSSIA ETF ETF 46434G798 335 7,850 SH   DFND 1 7,850 0 0
ISHARES MSCI SOUTH KOREA ETF ETF 464286772 1,875 30,150 SH   DFND 1 30,150 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 3,918 32,510 SH   DFND 1 32,510 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,996 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 45,863 314,410 SH   DFND 1 314,410 0 0
KLA-TENCOR CORP COM 482480100 287 1,610 SH   DFND 1 1,610 0 0
THE KRAFT HEINZ COMPANY COM 500754106 2,037 63,400 SH   DFND 1 63,400 0 0
LAM RESEARCH CORP COM 512807108 298 1,020 SH   DFND 1 1,020 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 32,152 151,020 SH   DFND 1 151,020 0 0
MANPOWERGROUP INC COM 56418H100 223 2,300 SH   DFND 1 2,300 0 0
MASTERCARD INC CL A 57636Q104 2,986 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 8,702 76,700 SH   DFND 1 76,700 0 0
MERITOR INC COM 59001K100 222 8,470 SH   DFND 1 8,470 0 0
METLIFE INC COM 59156R108 1,058 20,760 SH   DFND 1 20,760 0 0
THE MICHAELS COS INC COM 59408Q106 125 15,450 SH   DFND 1 15,450 0 0
MOODYS CORPORATION COM 20775CZK3 12,215 51,450 SH   DFND 1 51,450 0 0
NASDAQ INC COM 631103108 1,200 11,200 SH   DFND 1 11,200 0 0
NESTLE SA SPONSORED ADR 641069406 24,589 227,130 SH   DFND 1 227,130 0 0
NIC INC COM 62914B100 260 11,620 SH   DFND 1 11,620 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 6,766 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 15,634 326,310 SH   DFND 1 326,310 0 0
OMNICOM GROUP INC COM 681919106 654 8,070 SH   DFND 1 8,070 0 0
PHILLIPS 66 COM 718546104 16,886 151,570 SH   DFND 1 151,570 0 0
PRESTIGE CONSUMER HEALTHCARE COM 74112D101 282 6,960 SH   DFND 1 6,960 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 2,170 17,370 SH   DFND 1 17,370 0 0
RAYTHEON COMPANY COM 755111507 237 1,080 SH   DFND 1 1,080 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 9,040 222,320 SH   DFND 1 222,320 0 0
ROPER TECHNOLOGIES INC COM 776696106 25,009 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 9,635 160,660 SH   DFND 1 160,660 0 0
SEAGATE TECHNOLOGY COM G7945M107 238 4,000 SH   DFND 1 4,000 0 0
SESEN BIO INC COM 817763105 220 211,855 SH   DFND 1 211,855 0 0
SIERRA ONCOLOGY INC COM 82640U107 171 500,138 SH   DFND 1 500,138 0 0
SOPHIRIS BIO INC COM 83578Q209 111 300,900 SH   DFND 1 300,900 0 0
SPDR PORT SHRT TRM TRSRY ETF 78468R101 11,280 376,500 SH   DFND 1 376,500 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 207 131,271 SH   DFND 1 131,271 0 0
STAMPS.COM INC COM 852857200 215 2,580 SH   DFND 1 2,580 0 0
STERICYCLE INC COM 858912108 676 10,600 SH   DFND 1 10,600 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,367 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 227 6,300 SH   DFND 1 6,300 0 0
TEGNA INC COM 87901J105 203 12,180 SH   DFND 1 12,180 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 325 1,000 SH   DFND 1 1,000 0 0
THE TRAVELERS COMPANIES INC COM 893939AE8 205 1,500 SH   DFND 1 1,500 0 0
US BANCORP COM 902973304 7,552 127,370 SH   DFND 1 127,370 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 6,545 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 5,754 129,390 SH   DFND 1 129,390 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 1,787 9,320 SH   DFND 1 9,320 0 0
VANGUARD S&P 500 ETF ETF 922908363 15,071 50,950 SH   DFND 1 50,950 0 0
VANGUARD SHORT-TERM BOND ETF ETF 921937827 9,238 114,600 SH   DFND 1 114,600 0 0
VANGUARD SMALL- CAP ETF ETF 922908751 2,402 14,500 SH   DFND 1 14,500 0 0
VECTOR GROUP LTD COM 92240M108 266 19,834 SH   DFND 1 19,834 0 0
VIACOMCBC INC CL B 92556H206 325 7,755 SH   DFND 1 0 0 7,755
VISA INC CLASS A CL A 92826C839 28,805 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 10,625 136,570 SH   DFND 1 136,570 0 0
WATERS CORPORATION COM 941848103 9,475 40,550 SH   DFND 1 40,550 0 0
WEIGHT WATCHERS INTL INC COM 948626106 405 10,600 SH   DFND 1 10,600 0 0
WELLS FARGO & CO COM 949746101 88,226 1,639,880 SH   DFND 1 1,639,880 0 0
WESTERN DIGITAL CORP COM 958102105 242 3,810 SH   DFND 1 3,810 0 0
ZAFGEN INC COM 98885E103 223 200,621 SH   DFND 1 200,621 0 0
ZOETIS INC COM 98978V103 609 4,600 SH   DFND 1 4,600 0 0