The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 187,317 2,156,534 SH   DFND 1 1,776,336 0 380,198
ACACIA COMMUNICATIONS INC COM 00401C108 396 5,839 SH   DFND 1 5,839 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 33,875 1,019,729 SH   DFND 1 1,019,729 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 5,676 170,847 SH   OTR 2 170,847 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,399 149,585 SH   DFND 1 149,585 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 828 3,930 SH   DFND 1 3,930 0 0
ACTUANT CORP CL A NEW 00508X203 15,681 602,407 SH   DFND 1 602,407 0 0
ACTUANT CORP CL A NEW 00508X203 5,067 194,659 SH   OTR 2 194,659 0 0
ADECOAGRO S A COM L00849106 24,870 2,971,334 SH   DFND 1 2,971,334 0 0
ADECOAGRO S A COM L00849106 4,141 494,712 SH   OTR 2 494,712 0 0
ADOBE INC COM 00724F101 2,409,767 7,306,532 SH   DFND 1 7,029,899 0 276,633
ADOBE INC COM 00724F101 26,759 81,134 SH   OTR 2 81,134 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 53,029 331,099 SH   DFND 1 330,656 0 443
ADVANCED DISP SVCS INC DEL COM 00790X101 5,046 153,514 SH   DFND 1 153,514 0 0
ADVANCED DISP SVCS INC DEL COM 00790X101 129 3,910 SH   OTR 2 3,910 0 0
ADVANCED MICRO DEVICES INC COM 007903107 1,743 38,015 SH   DFND 1 38,015 0 0
AEROJET ROCKETDYNE HLDGS INC COM 007800105 494 10,809 SH   DFND 1 10,809 0 0
AES CORP COM 00130H105 56,605 2,844,484 SH   DFND 1 2,844,484 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 27,775 325,579 SH   DFND 1 324,388 0 1,191
AGIOS PHARMACEUTICALS INC COM 00847X104 26,184 548,353 SH   DFND 1 548,353 0 0
AGNICO EAGLE MINES LTD COM 008474108 45,014 730,628 SH   DFND 1 730,529 0 99
ALCON INC COM H01301128 28,943 511,058 SH   DFND 1 511,058 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 201,487 1,863,030 SH   DFND 1 1,669,793 0 193,237
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,147,533 14,839,851 SH   DFND 1 14,304,870 0 534,981
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 70,290 331,401 SH   OTR 2 331,401 0 0
ALIGN TECHNOLOGY INC COM 016255101 12,298 44,071 SH   DFND 1 44,071 0 0
ALLEGHANY CORP DEL COM 017175100 9,073 11,347 SH   DFND 1 11,347 0 0
ALLETE INC COM NEW 018522300 653 8,045 SH   DFND 1 8,045 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 628 5,600 SH   DFND 1 5,600 0 0
ALLIANT ENERGY CORP COM 018802108 106,702 1,949,960 SH   DFND 1 1,949,960 0 0
ALPHABET INC CAP STK CL A 02079K305 2,496,216 1,863,696 SH   DFND 1 1,794,735 0 68,961
ALPHABET INC CAP STK CL A 02079K305 37,690 28,140 SH   OTR 2 28,140 0 0
ALPHABET INC CAP STK CL C 02079K107 2,371,813 1,773,955 SH   DFND 1 1,694,939 0 79,016
ALPHABET INC CAP STK CL C 02079K107 26,194 19,591 SH   OTR 2 19,591 0 0
AMARIN CORP PLC CALL OPTIONS 023111206 6,432 300,000 SH Call DFND 1 0 0 0
AMAZON COM INC COM 023135106 4,725,939 2,557,548 SH   DFND 1 2,437,661 0 119,887
AMAZON COM INC COM 023135106 98,006 53,038 SH   OTR 2 53,038 0 0
AMC NETWORKS INC CL A 00164V103 627 15,880 SH   DFND 1 15,880 0 0
AMEDISYS INC COM 023436108 1,192 7,142 SH   DFND 1 7,142 0 0
AMEREN CORP COM 023608102 186,226 2,424,817 SH   DFND 1 2,424,817 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 980 34,163 SH   DFND 1 34,163 0 0
AMERICAN ASSETS TR INC COM 024013104 942 20,521 SH   DFND 1 20,521 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 78,458 1,668,260 SH   DFND 1 1,668,260 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 870 59,180 SH   DFND 1 59,180 0 0
AMERICAN ELEC PWR CO INC COM 025537101 409,101 4,328,648 SH   DFND 1 4,328,648 0 0
AMERICAN ELEC PWR CO INC UNIT 03/15/2022 025537127 9,521 175,892 SH   DFND 1 175,892 0 0
AMERICAN EXPRESS CO COM 025816109 4,408 35,411 SH   DFND 1 35,411 0 0
AMERICAN STS WTR CO COM 029899101 493 5,689 SH   DFND 1 5,689 0 0
AMERICAN TOWER CORP NEW COM 03027X100 357,145 1,554,021 SH   DFND 1 1,473,014 0 81,007
AMERICAN WTR WKS CO INC NEW COM 030420103 64,280 523,236 SH   DFND 1 523,236 0 0
AMERIPRISE FINL INC COM 03076C106 1,913 11,486 SH   DFND 1 11,486 0 0
AMERIS BANCORP COM 03076K108 52,857 1,242,512 SH   DFND 1 1,242,512 0 0
AMERIS BANCORP COM 03076K108 8,233 193,547 SH   OTR 2 193,547 0 0
AMETEK INC NEW COM 031100100 59,848 600,040 SH   DFND 1 597,843 0 2,197
AMGEN INC COM 031162100 3,689 15,301 SH   DFND 1 15,301 0 0
AMICUS THERAPEUTICS INC COM 03152W109 65,946 6,770,668 SH   DFND 1 6,770,668 0 0
AMICUS THERAPEUTICS INC COM 03152W109 4,301 441,553 SH   OTR 2 441,553 0 0
AMKOR TECHNOLOGY INC COM 031652100 1,139 87,639 SH   DFND 1 87,639 0 0
AMPHENOL CORP NEW CL A 032095101 37,044 342,268 SH   DFND 1 341,018 0 1,250
ANALOG DEVICES INC COM 032654105 46,110 388,004 SH   DFND 1 386,572 0 1,432
ANIXTER INTL INC COM 035290105 435 4,727 SH   DFND 1 4,727 0 0
ANTHEM INC COM 036752103 41,296 136,728 SH   DFND 1 136,728 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 33,836 1,105,031 SH   DFND 1 1,105,031 0 0
APPFOLIO INC COM CL A 03783C100 11,313 102,892 SH   DFND 1 102,892 0 0
APPFOLIO INC COM CL A 03783C100 1,935 17,597 SH   OTR 2 17,597 0 0
APPLE INC COM 037833100 4,080,184 13,894,720 SH   DFND 1 13,421,961 0 472,759
APPLE INC COM 037833100 42,660 145,274 SH   OTR 2 145,274 0 0
APTIV PLC SHS G6095L109 31,819 335,043 SH   DFND 1 333,861 0 1,182
AQUA AMERICA INC COM 03836W103 111,627 2,378,077 SH   DFND 1 2,378,077 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 8,184 2,943,789 SH   DFND 1 2,943,789 0 0
ARCOSA INC COM 039653100 1,609 36,112 SH   DFND 1 36,112 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 864 19,030 SH   DFND 1 19,030 0 0
ARGENX SE SPONSORED ADR 04016X101 44,140 274,981 SH   DFND 1 274,981 0 0
ARMSTRONG WORLD INDS INC NEW COM 04247X102 16,795 178,725 SH   DFND 1 178,725 0 0
ARMSTRONG WORLD INDS INC NEW COM 04247X102 2,604 27,710 SH   OTR 2 27,710 0 0
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 516 15,953 SH   DFND 1 15,953 0 0
ARYA SCIENCES ACQUISITION CO UNIT 10/04/2023 G3165V117 8,879 772,074 SH   DFND 1 772,074 0 0
ASBURY AUTOMOTIVE GROUP INC COM 043436104 1,030 9,212 SH   DFND 1 9,212 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 7,063 23,866 SH   DFND 1 23,312 0 554
ASSEMBLY BIOSCIENCES INC COM 045396108 48,010 2,346,510 SH   DFND 1 2,346,510 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 12,330 424,873 SH   DFND 1 424,873 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 2,106 72,568 SH   OTR 2 72,568 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,810,715 36,315,990 SH   DFND 1 35,397,926 0 918,064
ASTRAZENECA PLC SPONSORED ADR 046353108 16,851 337,968 SH   OTR 2 337,968 0 0
AT&T INC COM 00206R102 67,994 1,739,878 SH   DFND 1 1,739,878 0 0
ATKORE INTL GROUP INC COM 047649108 883 21,830 SH   DFND 1 21,830 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 26,881 715,881 SH   DFND 1 715,881 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 5,563 148,148 SH   OTR 2 148,148 0 0
ATMOS ENERGY CORP COM 049560105 53,221 475,785 SH   DFND 1 475,785 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 418 6,977 SH   DFND 1 6,977 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 229 1,342 SH   DFND 1 1,342 0 0
AVALARA INC COM 05338G106 16,691 227,867 SH   DFND 1 227,224 0 643
AVALONBAY CMNTYS INC COM 053484101 432 2,059 SH   DFND 1 2,059 0 0
AVANTOR INC COM 05352A100 37,365 2,058,671 SH   DFND 1 2,058,671 0 0
AXIS CAPITAL HOLDINGS LTD SHS G0692U109 24,499 412,150 SH   DFND 1 412,150 0 0
AXIS CAPITAL HOLDINGS LTD SHS G0692U109 3,637 61,193 SH   OTR 2 61,193 0 0
BAKER HUGHES COMPANY CL A 05722G100 10,319 402,626 SH   DFND 1 402,523 0 103
BANDWIDTH INC COM CL A 05988J103 22,349 348,932 SH   DFND 1 348,932 0 0
BANDWIDTH INC COM CL A 05988J103 7,941 123,980 SH   OTR 2 123,980 0 0
BANK AMER CORP COM 060505104 212,150 6,023,575 SH   DFND 1 6,023,575 0 0
BANKUNITED INC COM 06652K103 85,983 2,351,835 SH   DFND 1 2,351,835 0 0
BANKUNITED INC COM 06652K103 10,895 297,995 SH   OTR 2 297,995 0 0
BARRICK GOLD CORPORATION COM 067901108 28,122 1,512,755 SH   DFND 1 1,512,432 0 323
BEACON ROOFING SUPPLY INC COM 073685109 7,853 245,549 SH   DFND 1 245,549 0 0
BEACON ROOFING SUPPLY INC COM 073685109 1,256 39,275 SH   OTR 2 39,275 0 0
BEIGENE LTD SPONSORED ADR 07725L102 366 2,206 SH   DFND 1 2,206 0 0
BENCHMARK ELECTRS INC COM 08160H101 1,365 39,731 SH   DFND 1 39,731 0 0
BHP GROUP LTD SPONSORED ADS 088606108 19,581 357,906 SH   DFND 1 357,810 0 96
BIOGEN INC COM 09062X103 615 2,071 SH   DFND 1 2,071 0 0
BIOMARIN PHARMACEUTICAL INC CALL OPTIONS 09061G101 5,073 60,000 SH Call DFND 1 0 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 590,653 6,985,834 SH   DFND 1 6,762,899 0 222,935
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,594 54,339 SH   OTR 2 54,339 0 0
BJS RESTAURANTS INC COM 09180C106 617 16,263 SH   DFND 1 16,263 0 0
BLACK HILLS CORP COM 092113109 744 9,478 SH   DFND 1 9,478 0 0
BLACKBERRY LTD COM 09228F103 2,909 453,067 SH   DFND 1 453,067 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 4,858 60,642 SH   DFND 1 60,642 0 0
BMC STK HLDGS INC COM 05591B109 784 27,321 SH   DFND 1 27,321 0 0
BOEING CO COM 097023105 1,373,055 4,214,928 SH   DFND 1 4,004,114 0 210,814
BOEING CO COM 097023105 26,802 82,276 SH   OTR 2 82,276 0 0
BOOT BARN HLDGS INC COM 099406100 32,750 735,470 SH   DFND 1 735,470 0 0
BOOT BARN HLDGS INC COM 099406100 7,250 162,801 SH   OTR 2 162,801 0 0
BOSTON PROPERTIES INC COM 101121101 62,632 454,314 SH   DFND 1 454,314 0 0
BOSTON SCIENTIFIC CORP COM 101137107 509,273 11,262,105 SH   DFND 1 11,157,615 0 104,490
BOSTON SCIENTIFIC CORP COM 101137107 4,357 96,354 SH   OTR 2 96,354 0 0
BP PLC SPONSORED ADR 055622104 16,129 427,360 SH   DFND 1 427,253 0 107
BRIGHAM MINERALS INC CL A COM 10918L103 4,710 219,696 SH   DFND 1 219,630 0 66
BRIGHT HORIZONS FAM SOL IN D COM 109194100 39,376 262,001 SH   DFND 1 261,047 0 954
BRIGHTHOUSE FINL INC COM 10922N103 31,732 808,879 SH   DFND 1 808,879 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 35,025 3,427,104 SH   DFND 1 3,427,104 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 5,297 518,275 SH   OTR 2 518,275 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 37,971 591,548 SH   DFND 1 591,548 0 0
BROADCOM INC COM 11135F101 848,313 2,684,364 SH   DFND 1 2,651,362 0 33,002
BROADCOM INC COM 11135F101 10,583 33,489 SH   OTR 2 33,489 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 10,743 652,665 SH   DFND 1 652,665 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 3,576 217,247 SH   OTR 2 217,247 0 0
BROOKS AUTOMATION INC COM 114340102 29,860 711,628 SH   DFND 1 711,628 0 0
BROOKS AUTOMATION INC COM 114340102 5,209 124,137 SH   OTR 2 124,137 0 0
BRUKER CORP COM 116794108 648 12,706 SH   DFND 1 12,706 0 0
BUILDERS FIRSTSOURCE INC COM 12008R107 878 34,544 SH   DFND 1 34,544 0 0
BURLINGTON STORES INC COM 122017106 69,463 304,624 SH   DFND 1 303,832 0 792
BYLINE BANCORP INC COM 124411109 17,255 881,722 SH   DFND 1 881,722 0 0
BYLINE BANCORP INC COM 124411109 4,631 236,617 SH   OTR 2 236,617 0 0
CABLE ONE INC COM 12685J105 621 417 SH   DFND 1 417 0 0
CACTUS INC CL A 127203107 45,099 1,314,073 SH   DFND 1 1,314,004 0 69
CACTUS INC CL A 127203107 6,662 194,116 SH   OTR 2 194,116 0 0
CAPITAL ONE FINL CORP COM 14040H105 98,731 959,393 SH   DFND 1 959,393 0 0
CARDLYTICS INC COM 14161W105 26,206 416,897 SH   DFND 1 416,897 0 0
CARDLYTICS INC COM 14161W105 4,111 65,393 SH   OTR 2 65,393 0 0
CATALENT INC COM 148806102 48,615 863,507 SH   DFND 1 861,190 0 2,317
CBIZ INC COM 124805102 853 31,655 SH   DFND 1 31,655 0 0
CBRE GROUP INC CL A 12504L109 59,018 962,926 SH   DFND 1 959,589 0 3,337
CDW CORP COM 12514G108 104,345 730,501 SH   DFND 1 729,180 0 1,321
CENTENE CORP DEL COM 15135B101 68,196 1,084,719 SH   DFND 1 1,081,646 0 3,073
CF INDS HLDGS INC COM 125269100 4,675 97,934 SH   DFND 1 97,908 0 26
CHANGE HEALTHCARE INC COM 15912K100 6,921 422,270 SH   DFND 1 422,270 0 0
CHART INDS INC COM PAR $0.01 16115Q308 7,243 107,326 SH   DFND 1 107,305 0 21
CHARTER COMMUNICATIONS INC N CL A 16119P108 649 1,338 SH   DFND 1 1,338 0 0
CHEMED CORP NEW COM 16359R103 628 1,429 SH   DFND 1 1,429 0 0
CHENIERE ENERGY INC COM NEW 16411R208 103,329 1,691,981 SH   DFND 1 1,691,911 0 70
CHENIERE ENERGY PARTNERS LP COM UNIT 16411Q101 24,435 613,782 SH   DFND 1 613,782 0 0
CHEVRON CORP NEW COM 166764100 167,734 1,391,871 SH   DFND 1 1,391,841 0 30
CHIPOTLE MEXICAN GRILL INC COM 169656105 709,991 848,146 SH   DFND 1 802,834 0 45,312
CHIPOTLE MEXICAN GRILL INC COM 169656105 9,324 11,138 SH   OTR 2 11,138 0 0
CHUBB LIMITED COM H1467J104 140,000 899,398 SH   DFND 1 899,398 0 0
CHURCH & DWIGHT INC COM 171340102 31,833 452,560 SH   DFND 1 450,904 0 1,656
CIGNA CORP NEW COM 125523100 80,840 395,327 SH   DFND 1 395,327 0 0
CINTAS CORP COM 172908105 30,031 111,607 SH   DFND 1 111,206 0 401
CIRCOR INTL INC COM 17273K109 31,417 679,441 SH   DFND 1 679,441 0 0
CIRCOR INTL INC COM 17273K109 5,384 116,432 SH   OTR 2 116,432 0 0
CISCO SYS INC COM 17275R102 32,478 677,199 SH   DFND 1 677,199 0 0
CITIGROUP INC COM NEW 172967424 154,498 1,933,886 SH   DFND 1 1,933,886 0 0
CME GROUP INC COM 12572Q105 297 1,482 SH   DFND 1 1,482 0 0
CMS ENERGY CORP COM 125896100 153,116 2,436,604 SH   DFND 1 2,436,604 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 468 7,108 SH   DFND 1 7,108 0 0
COGNEX CORP COM 192422103 14,771 263,573 SH   DFND 1 262,650 0 923
COHEN & STEERS INC COM 19247A100 626 9,967 SH   DFND 1 9,967 0 0
COLONY CAP INC NEW CL A COM 19626G108 968 203,741 SH   DFND 1 203,741 0 0
COLUMBIA PPTY TR INC COM NEW 198287203 36,799 1,759,877 SH   DFND 1 1,759,877 0 0
COLUMBIA PPTY TR INC COM NEW 198287203 6,590 315,178 SH   OTR 2 315,178 0 0
COMCAST CORP NEW CL A 20030N101 189,271 4,208,837 SH   DFND 1 4,208,837 0 0
COMMERCIAL METALS CO COM 201723103 407 18,289 SH   DFND 1 18,289 0 0
CONAGRA BRANDS INC COM 205887102 73,637 2,150,623 SH   DFND 1 2,150,623 0 0
CONCHO RES INC COM 20605P101 15,701 179,291 SH   DFND 1 179,244 0 47
CONMED CORP COM 207410101 427 3,821 SH   DFND 1 3,821 0 0
CONOCOPHILLIPS COM 20825C104 19,432 298,820 SH   DFND 1 298,741 0 79
CONSTELLATION BRANDS INC CL A 21036P108 376,152 1,982,358 SH   DFND 1 1,827,322 0 155,036
CONSTELLATION BRANDS INC CL A 21036P108 4,357 22,962 SH   OTR 2 22,962 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 11,232 238,429 SH   DFND 1 238,429 0 0
CONSTELLIUM SE CL A SHS F21107101 8,970 669,383 SH   DFND 1 669,202 0 181
CONSTRUCTION PARTNERS INC COM CL A 21044C107 10,665 632,202 SH   DFND 1 632,202 0 0
CONSTRUCTION PARTNERS INC COM CL A 21044C107 2,090 123,872 SH   OTR 2 123,872 0 0
COOPER COS INC COM NEW 216648402 20,109 62,588 SH   DFND 1 62,360 0 228
COPART INC COM 217204106 1,471 16,170 SH   DFND 1 16,170 0 0
CORECIVIC INC COM 21871N101 5,560 319,906 SH   DFND 1 319,906 0 0
COSTAR GROUP INC COM 22160N109 41,284 69,003 SH   DFND 1 68,758 0 245
COSTCO WHSL CORP NEW COM 22160K105 1,474,333 5,016,101 SH   DFND 1 4,786,477 0 229,624
COSTCO WHSL CORP NEW COM 22160K105 15,977 54,360 SH   OTR 2 54,360 0 0
COUPA SOFTWARE INC COM 22266L106 668,668 4,572,088 SH   DFND 1 4,371,897 0 200,191
COUPA SOFTWARE INC COM 22266L106 21,079 144,133 SH   OTR 2 144,133 0 0
COUSINS PPTYS INC COM NEW 222795502 50,785 1,232,645 SH   DFND 1 1,232,645 0 0
COUSINS PPTYS INC COM NEW 222795502 8,207 199,202 SH   OTR 2 199,202 0 0
CRESTWOOD EQUITY PARTNERS LP UNIT LTD PARTNER 226344208 7,353 238,590 SH   DFND 1 238,590 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 73,912 519,956 SH   DFND 1 516,594 0 3,362
CYBERARK SOFTWARE LTD SHS M2682V108 73,488 630,362 SH   DFND 1 629,870 0 492
CYBERARK SOFTWARE LTD SHS M2682V108 9,032 77,477 SH   OTR 2 77,477 0 0
CYRUSONE INC COM 23283R100 13,286 203,056 SH   DFND 1 203,056 0 0
CYTOKINETICS INC COM NEW 23282W605 6,472 609,964 SH   DFND 1 609,964 0 0
DANA INCORPORATED COM 235825205 1,235 67,830 SH   DFND 1 67,830 0 0
DANAHER CORPORATION 4.75 MND CV PFD 235851300 1,784 1,513 SH   DFND 1 1,513 0 0
DANAHER CORPORATION COM 235851102 705,397 4,596,017 SH   DFND 1 4,359,810 0 236,207
DANAHER CORPORATION COM 235851102 8,134 53,000 SH   OTR 2 53,000 0 0
DARLING INGREDIENTS INC COM 237266101 59,952 2,135,051 SH   DFND 1 2,135,051 0 0
DARLING INGREDIENTS INC COM 237266101 10,447 372,048 SH   OTR 2 372,048 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,454 71,560 SH   DFND 1 71,560 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 6,524 111,556 SH   DFND 1 111,556 0 0
DENNYS CORP COM 24869P104 1,435 72,182 SH   DFND 1 72,182 0 0
DEXCOM INC COM 252131107 737,168 3,370,063 SH   DFND 1 3,209,939 0 160,124
DEXCOM INC COM 252131107 19,401 88,695 SH   OTR 2 88,695 0 0
DIAMONDBACK ENERGY INC COM 25278X109 25,279 272,227 SH   DFND 1 272,167 0 60
DISCOVER FINL SVCS COM 254709108 2,039 24,036 SH   DFND 1 24,036 0 0
DISNEY WALT CO COM DISNEY 254687106 1,210,393 8,368,895 SH   DFND 1 8,191,013 0 177,882
DISNEY WALT CO COM DISNEY 254687106 13,575 93,857 SH   OTR 2 93,857 0 0
DOLLAR GEN CORP NEW COM 256677105 38,125 244,421 SH   DFND 1 243,523 0 898
DOLLAR TREE INC COM 256746108 68,102 724,108 SH   DFND 1 723,192 0 916
DOMINION ENERGY INC COM 25746U109 213,529 2,578,235 SH   DFND 1 2,578,235 0 0
DOUGLAS EMMETT INC COM 25960P109 9,911 225,760 SH   DFND 1 225,760 0 0
DOW INC COM 260557103 24,295 443,909 SH   DFND 1 443,909 0 0
DRIL QUIP INC COM 262037104 5,529 117,870 SH   DFND 1 117,839 0 31
DTE ENERGY CO COM 233331107 125,719 968,034 SH   DFND 1 968,034 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 34,951 383,189 SH   DFND 1 383,189 0 0
DUNKIN BRANDS GROUP INC COM 265504100 16,152 213,817 SH   DFND 1 213,037 0 780
EAST WEST BANCORP INC COM 27579R104 82,053 1,684,871 SH   DFND 1 1,684,871 0 0
EAST WEST BANCORP INC COM 27579R104 11,244 230,888 SH   OTR 2 230,888 0 0
EBAY INC COM 278642103 1,291 35,765 SH   DFND 1 35,765 0 0
ECOLAB INC COM 278865100 1,597 8,277 SH   DFND 1 8,277 0 0
EDISON INTL COM 281020107 144,088 1,910,722 SH   DFND 1 1,910,722 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 1,101,421 4,721,253 SH   DFND 1 4,500,638 0 220,615
EDWARDS LIFESCIENCES CORP COM 28176E108 39,708 170,208 SH   OTR 2 170,208 0 0
EL PASO ELEC CO COM NEW 283677854 10,007 147,396 SH   DFND 1 147,396 0 0
EL PASO ELEC CO COM NEW 283677854 3,349 49,336 SH   OTR 2 49,336 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 13,222 448,970 SH   DFND 1 448,970 0 0
ELECTRONIC ARTS INC COM 285512109 705 6,559 SH   DFND 1 6,559 0 0
EMCOR GROUP INC COM 29084Q100 742 8,599 SH   DFND 1 8,599 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 29,524 547,256 SH   DFND 1 547,256 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 5,114 94,791 SH   OTR 2 94,791 0 0
EMERSON ELEC CO COM 291011104 78,129 1,024,513 SH   DFND 1 1,024,513 0 0
ENABLE MIDSTREAM PARTNERS LP COM UNIT RP IN 292480100 4,366 435,332 SH   DFND 1 435,332 0 0
ENBRIDGE INC COM 29250N105 92,345 2,322,318 SH   DFND 1 2,322,318 0 0
ENERGY TRANSFER LP COM UT LTD PTN 29273V100 38,169 2,974,977 SH   DFND 1 2,974,977 0 0
ENSIGN GROUP INC COM 29358P101 1,040 22,913 SH   DFND 1 22,913 0 0
ENTERGY CORP NEW COM 29364G103 143,409 1,197,070 SH   DFND 1 1,197,070 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 41,945 1,489,518 SH   DFND 1 1,489,518 0 0
EOG RES INC COM 26875P101 20,376 243,263 SH   DFND 1 243,199 0 64
EPIZYME INC COM 29428V104 377 15,309 SH   DFND 1 15,309 0 0
EQM MIDSTREAM PARTNERS LP UNIT LTD PARTN 26885B100 3,327 111,237 SH   DFND 1 111,237 0 0
EQUINIX INC COM 29444U700 107,949 184,940 SH   DFND 1 184,721 0 219
EQUINOR ASA SPONSORED ADR 29446M102 10,980 551,458 SH   DFND 1 551,330 0 128
EQUITRANS MIDSTREAM CORPORAT COM 294600101 1,809 135,412 SH   DFND 1 135,412 0 0
ESSENT GROUP LTD COM G3198U102 531 10,207 SH   DFND 1 10,207 0 0
ETSY INC COM 29786A106 21,787 491,795 SH   DFND 1 490,970 0 825
EVENTBRITE INC COM CL A 29975E109 4,062 201,346 SH   DFND 1 201,346 0 0
EVENTBRITE INC COM CL A 29975E109 35 1,754 SH   OTR 2 1,754 0 0
EVERBRIDGE INC COM 29978A104 14,753 188,955 SH   DFND 1 188,955 0 0
EVERBRIDGE INC COM 29978A104 4,854 62,162 SH   OTR 2 62,162 0 0
EVERI HLDGS INC COM 30034T103 970 72,258 SH   DFND 1 72,258 0 0
EVERSOURCE ENERGY COM 30040W108 35,887 421,849 SH   DFND 1 421,849 0 0
EVERTEC INC COM 30040P103 1,022 30,032 SH   DFND 1 30,032 0 0
EVO PMTS INC CL A COM 26927E104 8,248 312,276 SH   DFND 1 312,276 0 0
EVO PMTS INC CL A COM 26927E104 2,931 110,994 SH   OTR 2 110,994 0 0
EXACT SCIENCES CORP COM 30063P105 503,688 5,446,452 SH   DFND 1 5,108,226 0 338,226
EXACT SCIENCES CORP COM 30063P105 16,697 180,547 SH   OTR 2 180,547 0 0
EXELON CORP COM 30161N101 74,259 1,628,854 SH   DFND 1 1,628,854 0 0
EXTENDED STAY AMER INC UNIT 99/99/9999B 30224P200 3,511 236,264 SH   DFND 1 236,264 0 0
F M C CORP COM NEW 302491303 139,978 1,402,307 SH   DFND 1 1,400,617 0 1,690
FACEBOOK INC CL A 30303M102 2,594,654 12,641,434 SH   DFND 1 12,024,243 0 617,191
FACEBOOK INC CL A 30303M102 48,294 235,294 SH   OTR 2 235,294 0 0
FAIR ISAAC CORP COM 303250104 627 1,674 SH   DFND 1 1,674 0 0
FATE THERAPEUTICS INC COM 31189P102 25,578 1,307,006 SH   DFND 1 1,307,006 0 0
FEDERAL SIGNAL CORP COM 313855108 1,220 37,841 SH   DFND 1 37,841 0 0
FEDERATED INVS INC PA CL B 314211103 1,087 33,353 SH   DFND 1 33,353 0 0
FERRARI N V COM N3167Y103 6,968 42,091 SH   DFND 1 41,047 0 1,044
FERRO CORP COM 315405100 13,708 924,363 SH   DFND 1 924,363 0 0
FERRO CORP COM 315405100 1,986 133,906 SH   OTR 2 133,906 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 71,179 511,745 SH   DFND 1 509,826 0 1,919
FIRST BANCORP N C COM 318910106 20,255 507,519 SH   DFND 1 507,519 0 0
FIRST BANCORP N C COM 318910106 7,043 176,463 SH   OTR 2 176,463 0 0
FIRST FINL BANCORP OH COM 320209109 1,061 41,699 SH   DFND 1 41,699 0 0
FIRST FNDTN INC COM 32026V104 7,198 413,677 SH   DFND 1 413,677 0 0
FIRST FNDTN INC COM 32026V104 2,896 166,429 SH   OTR 2 166,429 0 0
FIRST SOLAR INC COM 336433107 8,646 154,508 SH   DFND 1 154,476 0 32
FIRSTENERGY CORP COM 337932107 165,341 3,402,081 SH   DFND 1 3,402,081 0 0
FISERV INC COM 337738108 68,843 595,375 SH   DFND 1 593,207 0 2,168
FIVE BELOW INC COM 33829M101 83,243 651,046 SH   DFND 1 650,269 0 777
FIVE BELOW INC COM 33829M101 7,051 55,145 SH   OTR 2 55,145 0 0
FLAGSTAR BANCORP INC COM PAR .001 337930705 664 17,372 SH   DFND 1 17,372 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 1,247,621 4,336,233 SH   DFND 1 4,130,576 0 205,657
FLEETCOR TECHNOLOGIES INC COM 339041105 14,394 50,028 SH   OTR 2 50,028 0 0
FLIR SYS INC COM 302445101 3,820 73,370 SH   DFND 1 73,370 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 13,747 466,466 SH   DFND 1 466,466 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 2,153 73,066 SH   OTR 2 73,066 0 0
FREEPORT-MCMORAN INC CL B 35671D857 8,526 649,854 SH   DFND 1 649,682 0 172
FRESHPET INC COM 358039105 4,159 70,371 SH   DFND 1 70,371 0 0
FRESHPET INC COM 358039105 1,694 28,676 SH   OTR 2 28,676 0 0
FTI CONSULTING INC COM 302941109 1,076 9,721 SH   DFND 1 9,721 0 0
G-III APPAREL GROUP LTD COM 36237H101 976 29,120 SH   DFND 1 29,120 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 66,207 1,537,907 SH   DFND 1 1,537,907 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 5,247 121,885 SH   OTR 2 121,885 0 0
GARDNER DENVER HLDGS INC COM 36555P107 23,111 630,069 SH   DFND 1 630,069 0 0
GARDNER DENVER HLDGS INC COM 36555P107 3,569 97,313 SH   OTR 2 97,313 0 0
GENERAC HLDGS INC COM 368736104 888 8,823 SH   DFND 1 8,823 0 0
GEO GROUP INC NEW COM 36162J106 613 36,935 SH   DFND 1 36,935 0 0
GLAUKOS CORP COM 377322102 25,228 463,152 SH   DFND 1 463,152 0 0
GLAUKOS CORP COM 377322102 5,283 96,992 SH   OTR 2 96,992 0 0
GLOBAL PMTS INC COM 37940X102 61,931 339,236 SH   DFND 1 337,989 0 1,247
GOLDMAN SACHS GROUP INC COM 38141G104 203,238 883,914 SH   DFND 1 754,217 0 129,697
GOOSEHEAD INS INC COM CL A 38267D109 14,255 336,192 SH   DFND 1 336,192 0 0
GOOSEHEAD INS INC COM CL A 38267D109 5,107 120,453 SH   OTR 2 120,453 0 0
GOSSAMER BIO INC COM 38341P102 9,461 605,299 SH   DFND 1 605,299 0 0
GRAFTECH INTL LTD COM 384313508 3,129 269,291 SH   DFND 1 269,214 0 77
GREAT LAKES DREDGE & DOCK CO COM 390607109 40,267 3,554,051 SH   DFND 1 3,554,051 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 5,628 496,739 SH   OTR 2 496,739 0 0
GREAT WESTN BANCORP INC COM 391416104 1,734 49,901 SH   DFND 1 49,901 0 0
GUARDANT HEALTH INC COM 40131M109 203,349 2,602,371 SH   DFND 1 2,495,060 0 107,311
GUARDANT HEALTH INC COM 40131M109 4,678 59,862 SH   OTR 2 59,862 0 0
GUIDEWIRE SOFTWARE INC COM 40171V100 44,789 408,027 SH   DFND 1 406,542 0 1,485
HALOZYME THERAPEUTICS INC COM 40637H109 471 26,592 SH   DFND 1 26,592 0 0
HANESBRANDS INC COM 410345102 1,868 125,816 SH   DFND 1 125,816 0 0
HARSCO CORP COM 415864107 28,666 1,245,804 SH   DFND 1 1,245,804 0 0
HARSCO CORP COM 415864107 4,598 199,836 SH   OTR 2 199,836 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 32,358 510,627 SH   DFND 1 510,627 0 0
HEALTHCARE SVCS GRP INC COM 421906108 4,565 187,710 SH   DFND 1 187,710 0 0
HEALTHCARE SVCS GRP INC COM 421906108 1,352 55,602 SH   OTR 2 55,602 0 0
HEALTHEQUITY INC COM 42226A107 10,974 148,160 SH   DFND 1 148,160 0 0
HEALTHEQUITY INC COM 42226A107 3,755 50,697 SH   OTR 2 50,697 0 0
HERSHA HOSPITALITY TR PR SHS BEN INT 427825500 1,282 88,080 SH   DFND 1 88,080 0 0
HERSHEY CO COM 427866108 1,300 8,848 SH   DFND 1 8,848 0 0
HILL ROM HLDGS INC COM 431475102 80,363 707,855 SH   DFND 1 706,081 0 1,774
HILLENBRAND INC COM 431571108 3,715 111,535 SH   DFND 1 111,535 0 0
HILLENBRAND INC COM 431571108 1,312 39,373 SH   OTR 2 39,373 0 0
HILLTOP HOLDINGS INC COM 432748101 1,211 48,568 SH   DFND 1 48,568 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 49,256 444,109 SH   DFND 1 442,536 0 1,573
HMS HLDGS CORP COM 40425J101 655 22,132 SH   DFND 1 22,132 0 0
HOME BANCSHARES INC COM 436893200 1,856 94,419 SH   DFND 1 94,419 0 0
HOME DEPOT INC COM 437076102 899,774 4,120,220 SH   DFND 1 3,857,398 0 262,822
HOME DEPOT INC COM 437076102 9,932 45,482 SH   OTR 2 45,482 0 0
HONEYWELL INTL INC COM 438516106 450 2,543 SH   DFND 1 2,543 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 61,535 1,699,878 SH   DFND 1 1,699,878 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 9,321 257,476 SH   OTR 2 257,476 0 0
HOUGHTON MIFFLIN HARCOURT CO COM 44157R109 3,409 545,512 SH   DFND 1 545,512 0 0
HOULIHAN LOKEY INC CL A 441593100 13,273 271,599 SH   DFND 1 271,599 0 0
HOULIHAN LOKEY INC CL A 441593100 5,317 108,805 SH   OTR 2 108,805 0 0
HOWARD HUGHES CORP COM 44267D107 57,881 456,474 SH   DFND 1 455,890 0 584
HUBSPOT INC COM 443573100 106,514 672,014 SH   DFND 1 671,339 0 675
HUBSPOT INC COM 443573100 10,784 68,035 SH   OTR 2 68,035 0 0
HUDSON LTD COM CL A G46408103 13,115 854,998 SH   DFND 1 854,998 0 0
HUDSON LTD COM CL A G46408103 4,661 303,821 SH   OTR 2 303,821 0 0
HUMANA INC COM 444859102 75,760 206,701 SH   DFND 1 206,701 0 0
HUNT J B TRANS SVCS INC COM 445658107 59,104 506,116 SH   DFND 1 504,762 0 1,354
HURON CONSULTING GROUP INC COM 447462102 13,741 199,954 SH   DFND 1 199,954 0 0
HURON CONSULTING GROUP INC COM 447462102 4,677 68,061 SH   OTR 2 68,061 0 0
IBERIABANK CORP COM 450828108 602 8,041 SH   DFND 1 8,041 0 0
IDEX CORP COM 45167R104 35,166 204,451 SH   DFND 1 203,707 0 744
IHS MARKIT LTD SHS G47567105 49,953 662,943 SH   DFND 1 660,510 0 2,433
ILLUMINA INC COM 452327109 1,322,744 3,987,292 SH   DFND 1 3,838,002 0 149,290
ILLUMINA INC COM 452327109 12,087 36,434 SH   OTR 2 36,434 0 0
IMAX CORP COM 45245E109 21,687 1,061,506 SH   DFND 1 1,061,506 0 0
IMAX CORP COM 45245E109 5,187 253,912 SH   OTR 2 253,912 0 0
IMMUNOMEDICS INC COM 452907108 63,979 3,023,577 SH   DFND 1 3,023,577 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 21,612 1,534,924 SH   DFND 1 1,534,924 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 7,338 521,162 SH   OTR 2 521,162 0 0
ING GROEP N V SPONSORED ADR 456837103 26,826 2,226,183 SH   DFND 1 2,226,183 0 0
INGERSOLL-RAND PLC SHS G47791101 38,066 286,383 SH   DFND 1 285,342 0 1,041
INPHI CORP COM 45772F107 23,221 313,721 SH   DFND 1 313,721 0 0
INPHI CORP COM 45772F107 8,276 111,804 SH   OTR 2 111,804 0 0
INSULET CORP COM 45784P101 12,597 73,579 SH   DFND 1 73,303 0 276
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 39,661 680,524 SH   DFND 1 680,524 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 6,420 110,154 SH   OTR 2 110,154 0 0
INTEL CORP COM 458140100 5,021 83,885 SH   DFND 1 83,885 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 20,906 168,706 SH   DFND 1 168,706 0 0
INTERNATIONAL BANCSHARES COR COM 459044103 1,951 45,300 SH   DFND 1 45,300 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 3,007 22,434 SH   DFND 1 22,434 0 0
INTERNATIONAL GAME TECHNOLOG SHS USD G4863A108 5,415 361,711 SH   DFND 1 361,711 0 0
INTERSECT ENT INC COM 46071F103 15,140 608,036 SH   DFND 1 608,036 0 0
INTERSECT ENT INC COM 46071F103 5,293 212,572 SH   OTR 2 212,572 0 0
INTERXION HOLDING N.V SHS N47279109 42,556 507,771 SH   DFND 1 507,771 0 0
INTERXION HOLDING N.V SHS N47279109 3,497 41,727 SH   OTR 2 41,727 0 0
INTUIT COM 461202103 262 1,002 SH   DFND 1 1,002 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 1,457,813 2,466,063 SH   DFND 1 2,352,140 0 113,923
INTUITIVE SURGICAL INC COM NEW 46120E602 36,583 61,884 SH   OTR 2 61,884 0 0
INVITAE CORP COM 46185L103 6,329 392,357 SH   DFND 1 392,357 0 0
IQVIA HLDGS INC COM 46266C105 106,911 691,934 SH   DFND 1 690,554 0 1,380
IRHYTHM TECHNOLOGIES INC COM 450056106 10,539 154,781 SH   DFND 1 154,781 0 0
ISHARES TR MSCI ACWI ETF 464288257 1,684 21,250 SH   DFND 1 20,847 0 403
ISHARES TR NORTH AMERN NAT 464287374 1,087 36,115 SH   DFND 1 35,965 0 150
ISHARES TR RUS 1000 GRW ETF 464287614 8,852 50,318 SH   DFND 1 33,496 0 16,822
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 623 4,176 SH   DFND 1 4,176 0 0
JELD-WEN HLDG INC COM 47580P103 16,532 706,199 SH   DFND 1 706,199 0 0
JELD-WEN HLDG INC COM 47580P103 3,792 161,988 SH   OTR 2 161,988 0 0
JOHNSON CTLS INTL PLC SHS G51502105 88,283 2,168,594 SH   DFND 1 2,168,594 0 0
JPMORGAN CHASE & CO COM 46625H100 959,198 6,880,901 SH   DFND 1 6,670,863 0 210,038
JPMORGAN CHASE & CO COM 46625H100 8,585 61,585 SH   OTR 2 61,585 0 0
K12 INC COM 48273U102 616 30,254 SH   DFND 1 30,254 0 0
KBR INC COM 48242W106 665 21,809 SH   DFND 1 21,809 0 0
KENNAMETAL INC COM 489170100 1,493 40,467 SH   DFND 1 40,467 0 0
KENNEDY-WILSON HLDGS INC COM 489398107 915 41,042 SH   DFND 1 41,042 0 0
KINDER MORGAN INC DEL COM 49456B101 63,607 3,004,585 SH   DFND 1 3,004,393 0 192
KKR & CO INC CL A 48251W104 1,577 54,078 SH   DFND 1 54,078 0 0
KNOLL INC COM NEW 498904200 1,418 56,134 SH   DFND 1 56,134 0 0
KONTOOR BRANDS INC COM 50050N103 6,260 149,075 SH   DFND 1 149,075 0 0
KONTOOR BRANDS INC COM 50050N103 2,169 51,666 SH   OTR 2 51,666 0 0
KORN FERRY COM NEW 500643200 46,861 1,105,208 SH   DFND 1 1,105,208 0 0
KORN FERRY COM NEW 500643200 7,608 179,440 SH   OTR 2 179,440 0 0
KOSMOS ENERGY LTD COM 500688106 9,971 1,749,300 SH   DFND 1 1,748,941 0 359
L3HARRIS TECHNOLOGIES INC COM 502431109 34,203 172,858 SH   DFND 1 172,232 0 626
LABORATORY CORP AMER HLDGS COM NEW 50540R409 96,494 570,395 SH   DFND 1 570,395 0 0
LAM RESEARCH CORP COM 512807108 45,396 155,253 SH   DFND 1 154,762 0 491
LAMB WESTON HLDGS INC COM 513272104 29,281 340,358 SH   DFND 1 339,118 0 1,240
LATTICE SEMICONDUCTOR CORP COM 518415104 367 19,200 SH   DFND 1 19,200 0 0
LAUDER ESTEE COS INC CL A 518439104 1,237,180 5,990,025 SH   DFND 1 5,711,129 0 278,896
LAUDER ESTEE COS INC CL A 518439104 13,771 66,676 SH   OTR 2 66,676 0 0
LAUREATE EDUCATION INC CL A 518613203 5,110 290,148 SH   DFND 1 290,148 0 0
LAZARD LTD SHS A G54050102 24,898 623,081 SH   DFND 1 623,081 0 0
LEXINGTON REALTY TRUST COM 529043101 1,598 150,493 SH   DFND 1 150,493 0 0
LIBERTY GLOBAL PLC SHS CL C G5480U120 5,053 231,843 SH   DFND 1 231,843 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 6,448 61,833 SH   DFND 1 61,833 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 2,099 20,124 SH   OTR 2 20,124 0 0
LILLY ELI & CO COM 532457108 587,001 4,466,262 SH   DFND 1 4,312,634 0 153,628
LILLY ELI & CO COM 532457108 6,074 46,216 SH   OTR 2 46,216 0 0
LINDE PLC SHS G5494J103 210,815 990,209 SH   DFND 1 990,196 0 13
LIVEPERSON INC COM 538146101 4,788 129,386 SH   DFND 1 129,386 0 0
LIVEPERSON INC COM 538146101 1,881 50,844 SH   OTR 2 50,844 0 0
LIVERAMP HLDGS INC COM 53815P108 9,739 202,601 SH   DFND 1 202,601 0 0
LIVERAMP HLDGS INC COM 53815P108 3,390 70,531 SH   OTR 2 70,531 0 0
LIVONGO HEALTH INC COM 539183103 13,980 557,847 SH   DFND 1 557,847 0 0
LIVONGO HEALTH INC COM 539183103 4,432 176,865 SH   OTR 2 176,865 0 0
LOCKHEED MARTIN CORP COM 539830109 15,551 39,938 SH   DFND 1 39,938 0 0
LOWES COS INC COM 548661107 112,684 940,916 SH   DFND 1 940,916 0 0
LPL FINL HLDGS INC COM 50212V100 1,838 19,927 SH   DFND 1 19,927 0 0
LTC PPTYS INC COM 502175102 1,105 24,684 SH   DFND 1 24,684 0 0
LULULEMON ATHLETICA INC COM 550021109 1,826,212 7,882,816 SH   DFND 1 7,563,012 0 319,804
LULULEMON ATHLETICA INC COM 550021109 39,854 172,028 SH   OTR 2 172,028 0 0
MACK CALI RLTY CORP COM 554489104 629 27,214 SH   DFND 1 27,214 0 0
MADDEN STEVEN LTD COM 556269108 68,847 1,600,736 SH   DFND 1 1,600,736 0 0
MADDEN STEVEN LTD COM 556269108 9,849 228,989 SH   OTR 2 228,989 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 23,691 260,022 SH   DFND 1 260,022 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 1,495 16,408 SH   OTR 2 16,408 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 11,251 178,962 SH   DFND 1 178,962 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 1,619 70,718 SH   DFND 1 70,718 0 0
MARATHON PETE CORP COM 56585A102 13,880 230,367 SH   DFND 1 230,312 0 55
MARCUS & MILLICHAP INC COM 566324109 538 14,443 SH   DFND 1 14,443 0 0
MARRIOTT INTL INC NEW CL A 571903202 731,496 4,830,588 SH   DFND 1 4,494,932 0 335,656
MARRIOTT INTL INC NEW CL A 571903202 8,643 57,079 SH   OTR 2 57,079 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 93,856 3,533,726 SH   DFND 1 3,524,730 0 8,996
MASTERCARD INC CL A 57636Q104 3,630,254 12,157,988 SH   DFND 1 11,548,706 0 609,282
MASTERCARD INC CL A 57636Q104 77,813 260,603 SH   OTR 2 260,603 0 0
MATCH GROUP INC COM 57665R106 654 7,966 SH   DFND 1 7,966 0 0
MAXIMUS INC COM 577933104 1,518 20,411 SH   DFND 1 20,411 0 0
MAXLINEAR INC COM 57776J100 16,449 775,193 SH   DFND 1 775,193 0 0
MAXLINEAR INC COM 57776J100 5,639 265,721 SH   OTR 2 265,721 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 5,017 534,852 SH   DFND 1 534,852 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 2,001 213,358 SH   OTR 2 213,358 0 0
MCCORMICK & CO INC COM NON VTG 579780206 13,068 76,992 SH   DFND 1 76,711 0 281
MCDONALDS CORP COM 580135101 86,114 435,777 SH   DFND 1 435,777 0 0
MEDPACE HLDGS INC COM 58506Q109 814 9,681 SH   DFND 1 9,681 0 0
MERCADOLIBRE INC COM 58733R102 300,199 524,879 SH   DFND 1 482,452 0 42,427
MERCADOLIBRE INC COM 58733R102 27,114 47,407 SH   OTR 2 47,407 0 0
MERCK & CO INC COM 58933Y105 61,717 678,586 SH   DFND 1 678,586 0 0
MERIT MED SYS INC COM 589889104 1,507 48,273 SH   DFND 1 48,273 0 0
METHODE ELECTRS INC COM 591520200 1,474 37,457 SH   DFND 1 37,457 0 0
METLIFE INC COM 59156R108 179,815 3,527,868 SH   DFND 1 3,527,868 0 0
MFA FINL INC COM 55272X102 70,529 9,219,491 SH   DFND 1 9,219,491 0 0
MFA FINL INC COM 55272X102 9,788 1,279,485 SH   OTR 2 1,279,485 0 0
MGM RESORTS INTERNATIONAL COM 552953101 6,770 203,476 SH   DFND 1 203,476 0 0
MGP INGREDIENTS INC NEW COM 55303J106 15,582 321,601 SH   DFND 1 321,601 0 0
MGP INGREDIENTS INC NEW COM 55303J106 5,658 116,783 SH   OTR 2 116,783 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 20,083 191,774 SH   DFND 1 191,068 0 706
MICROSOFT CORP COM 594918104 4,543,443 28,810,672 SH   DFND 1 27,656,621 0 1,154,051
MICROSOFT CORP COM 594918104 76,451 484,788 SH   OTR 2 484,788 0 0
MIRATI THERAPEUTICS INC COM 60468T105 71,761 556,894 SH   DFND 1 556,894 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,968 30,793 SH   OTR 2 30,793 0 0
MOBILE MINI INC COM 60740F105 80,177 2,114,949 SH   DFND 1 2,114,949 0 0
MOBILE MINI INC COM 60740F105 12,198 321,753 SH   OTR 2 321,753 0 0
MOELIS & CO CL A 60786M105 32,027 1,003,344 SH   DFND 1 1,003,344 0 0
MOELIS & CO CL A 60786M105 4,635 145,200 SH   OTR 2 145,200 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 11,838 600,000 SH   DFND 1 600,000 0 0
MONDELEZ INTL INC CL A 609207105 225,040 4,085,692 SH   DFND 1 3,623,292 0 462,400
MONOLITHIC PWR SYS INC COM 609839105 37,706 211,806 SH   DFND 1 211,806 0 0
MONOLITHIC PWR SYS INC COM 609839105 6,293 35,351 SH   OTR 2 35,351 0 0
MONRO INC COM 610236101 18,741 239,661 SH   DFND 1 239,661 0 0
MONRO INC COM 610236101 6,732 86,082 SH   OTR 2 86,082 0 0
MOODYS CORP COM 615369105 34,824 146,683 SH   DFND 1 146,163 0 520
MORGAN STANLEY COM NEW 617446448 6,965 136,239 SH   DFND 1 136,239 0 0
MPLX LP COM UNIT REP LTD 55336V100 21,886 859,631 SH   DFND 1 859,631 0 0
MRC GLOBAL INC COM 55345K103 650 47,619 SH   DFND 1 47,619 0 0
MUELLER WTR PRODS INC COM SER A 624758108 9,439 787,974 SH   DFND 1 787,974 0 0
MUELLER WTR PRODS INC COM SER A 624758108 3,394 283,267 SH   OTR 2 283,267 0 0
NATERA INC COM 632307104 79,444 2,358,086 SH   DFND 1 2,358,086 0 0
NATERA INC COM 632307104 5,871 174,269 SH   OTR 2 174,269 0 0
NATIONAL ENERGY SERVICES REU SHS G6375R107 6,046 662,932 SH   DFND 1 662,788 0 144
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 23,081 686,541 SH   DFND 1 686,541 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 8,510 253,115 SH   OTR 2 253,115 0 0
NATIONAL VISION HLDGS INC COM 63845R107 9,959 307,095 SH   DFND 1 307,095 0 0
NATIONAL VISION HLDGS INC COM 63845R107 3,726 114,881 SH   OTR 2 114,881 0 0
NETFLIX INC COM 64110L106 2,460,245 7,603,440 SH   DFND 1 7,232,017 0 371,423
NETFLIX INC COM 64110L106 55,942 172,889 SH   OTR 2 172,889 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 26,607 247,528 SH   DFND 1 247,528 0 0
NEWMONT GOLDCORP CORPORATION COM 651639106 20,295 467,100 SH   DFND 1 467,006 0 94
NEXPOINT RESIDENTIAL TR INC COM 65341D102 451 10,020 SH   DFND 1 10,020 0 0
NEXTCURE INC COM 65343E108 5,633 100,000 SH   DFND 1 100,000 0 0
NEXTERA ENERGY INC COM 65339F101 273,675 1,130,141 SH   DFND 1 1,130,141 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 184,851 3,510,931 SH   DFND 1 3,510,879 0 52
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 9,929 188,589 SH   OTR 2 188,589 0 0
NIKE INC CL B 654106103 2,288,453 22,588,612 SH   DFND 1 21,296,239 0 1,292,373
NIKE INC CL B 654106103 55,279 545,645 SH   OTR 2 545,645 0 0
NISOURCE INC COM 65473P105 85,011 3,053,541 SH   DFND 1 3,053,541 0 0
NLIGHT INC COM 65487K100 18,767 925,395 SH   DFND 1 925,395 0 0
NLIGHT INC COM 65487K100 4,699 231,687 SH   OTR 2 231,687 0 0
NN INC COM 629337106 13,780 1,489,696 SH   DFND 1 1,489,696 0 0
NN INC COM 629337106 2,117 228,884 SH   OTR 2 228,884 0 0
NOBLE ENERGY INC COM 655044105 114,235 4,598,837 SH   DFND 1 4,595,346 0 3,491
NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST 65506L105 4,778 179,889 SH   DFND 1 179,889 0 0
NORDSON CORP COM 655663102 18,567 114,022 SH   DFND 1 113,777 0 245
NORFOLK SOUTHERN CORP COM 655844108 21,217 109,293 SH   DFND 1 109,293 0 0
NORTHROP GRUMMAN CORP COM 666807102 1,868 5,431 SH   DFND 1 5,431 0 0
NORTHWESTERN CORP COM NEW 668074305 563 7,857 SH   DFND 1 7,857 0 0
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 665 11,380 SH   DFND 1 11,380 0 0
NOVARTIS A G SPONSORED ADR 66987V109 266,566 2,815,145 SH   DFND 1 2,747,442 0 67,703
NOVARTIS A G SPONSORED ADR 66987V109 2,538 26,798 SH   OTR 2 26,798 0 0
NOVO-NORDISK A S ADR 670100205 65,539 1,132,334 SH   DFND 1 1,132,334 0 0
NOVOCURE LTD ORD SHS G6674U108 1,128 13,380 SH   DFND 1 13,380 0 0
NUTRIEN LTD COM 67077M108 7,738 161,520 SH   DFND 1 161,479 0 41
NVIDIA CORP COM 67066G104 1,920,323 8,161,168 SH   DFND 1 7,861,944 0 299,224
NVIDIA CORP COM 67066G104 21,286 90,463 SH   OTR 2 90,463 0 0
OFG BANCORP COM 67103X102 606 25,666 SH   DFND 1 25,666 0 0
OKTA INC CL A 679295105 1,005 8,710 SH   DFND 1 8,710 0 0
OMNICOM GROUP INC COM 681919106 2,032 25,082 SH   DFND 1 25,082 0 0
ONEOK INC NEW COM 682680103 148,764 1,965,962 SH   DFND 1 1,965,962 0 0
ORACLE CORP COM 68389X105 2,835 53,507 SH   DFND 1 53,507 0 0
PALO ALTO NETWORKS INC COM 697435105 35,663 154,218 SH   DFND 1 153,666 0 552
PARKER HANNIFIN CORP COM 701094104 115,855 562,896 SH   DFND 1 405,482 0 157,414
PARSLEY ENERGY INC CL A 701877102 21,277 1,125,160 SH   DFND 1 1,124,858 0 302
PARSONS CORPORATION COM 70202L102 3,681 89,161 SH   DFND 1 89,161 0 0
PATTERN ENERGY GROUP INC CL A 70338P100 367 13,701 SH   DFND 1 13,701 0 0
PAYCHEX INC COM 704326107 617 7,252 SH   DFND 1 7,252 0 0
PAYCOM SOFTWARE INC COM 70432V102 31,582 119,285 SH   DFND 1 119,001 0 284
PAYLOCITY HLDG CORP COM 70438V106 627 5,193 SH   DFND 1 5,193 0 0
PAYPAL HLDGS INC COM 70450Y103 925,275 8,553,892 SH   DFND 1 8,102,451 0 451,441
PAYPAL HLDGS INC COM 70450Y103 19,147 177,010 SH   OTR 2 177,010 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 28,820 1,074,968 SH   DFND 1 1,074,968 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 4,850 180,893 SH   OTR 2 180,893 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 53,500 1,883,810 SH   DFND 1 1,883,810 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 1,731 60,947 SH   OTR 2 60,947 0 0
PEMBINA PIPELINE CORP COM 706327103 88,643 2,391,804 SH   DFND 1 2,391,804 0 0
PENN NATL GAMING INC COM 707569109 28,302 1,107,273 SH   DFND 1 1,107,273 0 0
PENN NATL GAMING INC COM 707569109 3,950 154,552 SH   OTR 2 154,552 0 0
PENTAIR PLC SHS G7S00T104 7,170 156,316 SH   DFND 1 156,316 0 0
PEPSICO INC COM 713448108 111,925 818,944 SH   DFND 1 818,944 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 90,970 1,767,111 SH   DFND 1 1,767,111 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 13,596 264,094 SH   OTR 2 264,094 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 3,563 223,500 SH   DFND 1 223,441 0 59
PFIZER INC COM 717081103 83,273 2,125,396 SH   DFND 1 2,125,396 0 0
PGT INNOVATIONS INC COM 69336V101 8,096 542,995 SH   DFND 1 542,995 0 0
PGT INNOVATIONS INC COM 69336V101 2,535 170,007 SH   OTR 2 170,007 0 0
PHILIP MORRIS INTL INC COM 718172109 25,576 300,574 SH   DFND 1 300,574 0 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 11,886 192,827 SH   DFND 1 192,827 0 0
PHREESIA INC COM 71944F106 10,255 384,933 SH   DFND 1 384,933 0 0
PHREESIA INC COM 71944F106 676 25,380 SH   OTR 2 25,380 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 115,846 1,810,096 SH   DFND 1 1,810,096 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 11,366 177,587 SH   OTR 2 177,587 0 0
PINTEREST INC CL A 72352L106 11,931 640,093 SH   DFND 1 638,105 0 1,988
PIONEER NAT RES CO COM 723787107 7,899 52,183 SH   DFND 1 52,172 0 11
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 26,655 1,449,419 SH   DFND 1 1,449,419 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 2,228 117,580 SH   DFND 1 117,580 0 0
PLANET FITNESS INC CL A 72703H101 62,660 839,043 SH   DFND 1 838,340 0 703
PLANET FITNESS INC CL A 72703H101 7,861 105,269 SH   OTR 2 105,269 0 0
PLAYA HOTELS & RESORTS NV SHS N70544106 3,509 417,795 SH   DFND 1 417,795 0 0
PNC FINL SVCS GROUP INC COM 693475105 180,999 1,133,863 SH   DFND 1 1,133,863 0 0
PNM RES INC COM 69349H107 12,768 251,786 SH   DFND 1 251,786 0 0
PNM RES INC COM 69349H107 3,427 67,574 SH   OTR 2 67,574 0 0
POLYONE CORP COM 73179P106 51,716 1,405,728 SH   DFND 1 1,405,728 0 0
POLYONE CORP COM 73179P106 7,303 198,494 SH   OTR 2 198,494 0 0
PORTLAND GEN ELEC CO COM NEW 736508847 777 13,928 SH   DFND 1 13,928 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 277 11,588 SH   DFND 1 11,588 0 0
PPL CORP COM 69351T106 34,218 953,686 SH   DFND 1 953,686 0 0
PRA HEALTH SCIENCES INC COM 69354M108 14,197 127,726 SH   DFND 1 127,726 0 0
PREMIER INC CL A 74051N102 21,606 570,392 SH   DFND 1 570,392 0 0
PREMIER INC CL A 74051N102 3,272 86,376 SH   OTR 2 86,376 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 12,975 320,376 SH   DFND 1 320,376 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 4,870 120,236 SH   OTR 2 120,236 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 17,655 322,288 SH   DFND 1 322,288 0 0
PROCTER & GAMBLE CO COM 742718109 93,389 747,707 SH   DFND 1 747,707 0 0
PROLOGIS INC COM 74340W103 49,883 559,602 SH   DFND 1 559,602 0 0
PROOFPOINT INC COM 743424103 59,962 522,405 SH   DFND 1 521,303 0 1,102
PROOFPOINT INC COM 743424103 8,798 76,654 SH   OTR 2 76,654 0 0
PROPETRO HLDG CORP COM 74347M108 4,122 366,360 SH   DFND 1 366,291 0 69
PROQR THRAPEUTICS N V SHS EURO N71542109 26,070 2,630,626 SH   DFND 1 2,630,626 0 0
PROSIGHT GLOBAL INC COM 74349J103 8,587 532,335 SH   DFND 1 532,335 0 0
PROSIGHT GLOBAL INC COM 74349J103 1,280 79,358 SH   OTR 2 79,358 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 65,405 1,107,621 SH   DFND 1 1,107,621 0 0
Q2 HLDGS INC COM 74736L109 18,581 229,167 SH   DFND 1 229,167 0 0
Q2 HLDGS INC COM 74736L109 6,262 77,232 SH   OTR 2 77,232 0 0
QTS RLTY TR INC COM CL A 74736A103 41,574 766,047 SH   DFND 1 766,047 0 0
QTS RLTY TR INC COM CL A 74736A103 9,410 173,396 SH   OTR 2 173,396 0 0
QUALCOMM INC COM 747525103 1,035,739 11,739,085 SH   DFND 1 11,264,848 0 474,237
QUALCOMM INC COM 747525103 12,024 136,275 SH   OTR 2 136,275 0 0
QUANTA SVCS INC COM 74762E102 81,145 1,993,248 SH   DFND 1 1,988,476 0 4,772
QURATE RETAIL INC COM SER A 74915M100 1,367 162,135 SH   DFND 1 162,135 0 0
RADIAN GROUP INC COM 750236101 1,011 40,189 SH   DFND 1 40,189 0 0
RATTLER MIDSTREAM LP COM UNITS 75419T103 5,782 325,007 SH   DFND 1 325,007 0 0
RBC BEARINGS INC COM 75524B104 662 4,182 SH   DFND 1 4,182 0 0
RENAISSANCERE HOLDINGS LTD COM G7496G103 4,057 20,698 SH   DFND 1 20,698 0 0
RENASANT CORP COM 75970E107 15,928 449,684 SH   DFND 1 449,684 0 0
RENASANT CORP COM 75970E107 5,705 161,076 SH   OTR 2 161,076 0 0
REPLIGEN CORP COM 759916109 17,854 193,016 SH   DFND 1 193,016 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 32,185 1,822,507 SH   DFND 1 1,822,507 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 6,290 356,160 SH   OTR 2 356,160 0 0
REXNORD CORP NEW COM 76169B102 76,817 2,354,894 SH   DFND 1 2,354,894 0 0
REXNORD CORP NEW COM 76169B102 11,748 360,152 SH   OTR 2 360,152 0 0
RINGCENTRAL INC CL A 76680R206 104,475 619,402 SH   DFND 1 551,908 0 67,494
RINGCENTRAL INC CL A 76680R206 12,686 75,214 SH   OTR 2 75,214 0 0
ROPER TECHNOLOGIES INC COM 776696106 41,962 118,460 SH   DFND 1 118,023 0 437
ROSS STORES INC COM 778296103 84,838 728,720 SH   DFND 1 727,315 0 1,405
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 95,369 1,616,974 SH   DFND 1 1,616,914 0 60
ROYAL GOLD INC COM 780287108 15,247 124,719 SH   DFND 1 124,719 0 0
S&P GLOBAL INC COM 78409V104 855,110 3,131,699 SH   DFND 1 2,983,006 0 148,693
S&P GLOBAL INC COM 78409V104 9,756 35,730 SH   OTR 2 35,730 0 0
SAGE THERAPEUTICS INC COM 78667J108 31,129 431,209 SH   DFND 1 431,209 0 0
SAGE THERAPEUTICS INC PUT OPTIONS 78667J108 5,790 80,200 SH Put DFND 1 80,200 0 0
SAIA INC COM 78709Y105 76,585 822,430 SH   DFND 1 822,430 0 0
SAIA INC COM 78709Y105 12,416 133,337 SH   OTR 2 133,337 0 0
SALESFORCE COM INC COM 79466L302 3,096,469 19,038,794 SH   DFND 1 18,154,750 0 884,044
SALESFORCE COM INC COM 79466L302 43,565 267,859 SH   OTR 2 267,859 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 9,028 1,211,768 SH   DFND 1 1,211,768 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 2,759 370,383 SH   OTR 2 370,383 0 0
SAP SE SPON ADR 803054204 230,080 1,717,146 SH   DFND 1 1,612,974 0 104,172
SAREPTA THERAPEUTICS INC COM 803607100 99,362 770,011 SH   DFND 1 770,011 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 97,895 406,219 SH   DFND 1 405,436 0 783
SCHLUMBERGER LTD COM 806857108 87,706 2,181,751 SH   DFND 1 2,181,659 0 92
SCHWEITZER-MAUDUIT INTL INC COM 808541106 679 16,169 SH   DFND 1 16,169 0 0
SEA LTD SPONSORED ADS 81141R100 27,777 690,635 SH   DFND 1 690,635 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 11,042 361,191 SH   DFND 1 361,191 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 2,683 87,768 SH   OTR 2 87,768 0 0
SEAWORLD ENTMT INC COM 81282V100 4,564 143,939 SH   DFND 1 143,939 0 0
SELECT MED HLDGS CORP COM 81619Q105 1,743 74,668 SH   DFND 1 74,668 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 414 6,901 SH   DFND 1 6,863 0 38
SEMPRA ENERGY 6% PFD CONV A 816851406 18,806 156,694 SH   DFND 1 156,694 0 0
SEMPRA ENERGY COM 816851109 137,691 908,971 SH   DFND 1 908,971 0 0
SERVICE CORP INTL COM 817565104 299 6,487 SH   DFND 1 6,487 0 0
SERVICENOW INC COM 81762P102 837,720 2,967,272 SH   DFND 1 2,845,660 0 121,612
SERVICENOW INC COM 81762P102 9,166 32,467 SH   OTR 2 32,467 0 0
SHOCKWAVE MED INC COM 82489T104 25,488 580,334 SH   DFND 1 580,334 0 0
SHOPIFY INC CL A 82509L107 1,237,794 3,113,321 SH   DFND 1 2,993,380 0 119,941
SHOPIFY INC CL A 82509L107 38,741 97,441 SH   OTR 2 97,441 0 0
SILICON LABORATORIES INC COM 826919102 3,202 27,604 SH   DFND 1 27,604 0 0
SILK ROAD MEDICAL INC COM 82710M100 45,929 1,137,436 SH   DFND 1 1,137,436 0 0
SILK ROAD MEDICAL INC COM 82710M100 3,571 88,427 SH   OTR 2 88,427 0 0
SKYWEST INC COM 830879102 497 7,686 SH   DFND 1 7,686 0 0
SLM CORP COM 78442P106 75,108 8,429,616 SH   DFND 1 8,429,582 0 34
SMILEDIRECTCLUB INC CL A COM 83192H106 5,416 619,629 SH   DFND 1 619,629 0 0
SOUTHERN COPPER CORP COM 84265V105 16,262 382,817 SH   DFND 1 382,715 0 102
SOUTHWEST AIRLS CO COM 844741108 615 11,399 SH   DFND 1 11,399 0 0
SPDR S&P MIDCAP 400 ETF TR UTSER1 S&PDCRP 78467Y107 676 1,802 SH   DFND 1 1,663 0 139
SPDR SERIES TRUST PUT OPTIONS 78464A870 19,022 200,000 SH Put DFND 1 200,000 0 0
SPDR SERIES TRUST S&P METALS MNG 78464A755 3,151 107,563 SH   DFND 1 106,978 0 585
SPIRIT AIRLS INC COM 848577102 352 8,735 SH   DFND 1 8,735 0 0
SPLUNK INC COM 848637104 901,468 6,019,017 SH   DFND 1 5,681,768 0 337,249
SPLUNK INC COM 848637104 11,365 75,883 SH   OTR 2 75,883 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 3,794 25,371 SH   DFND 1 25,371 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,678 251,447 SH   DFND 1 251,447 0 0
SQUARE INC CL A 852234103 363,367 5,808,290 SH   DFND 1 5,569,842 0 238,448
SQUARE INC CL A 852234103 3,932 62,856 SH   OTR 2 62,856 0 0
STANLEY BLACK & DECKER INC COM 854502101 23,032 138,962 SH   DFND 1 138,462 0 500
STARWOOD PPTY TR INC COM 85571B105 55,932 2,249,872 SH   DFND 1 2,244,263 0 5,609
STERLING BANCORP INC COM 85917W102 639 78,924 SH   DFND 1 78,924 0 0
STIFEL FINL CORP COM 860630102 1,553 25,606 SH   DFND 1 25,606 0 0
STONERIDGE INC COM 86183P102 7,721 263,346 SH   DFND 1 263,346 0 0
STONERIDGE INC COM 86183P102 1,229 41,921 SH   OTR 2 41,921 0 0
STRYKER CORP COM 863667101 637 3,033 SH   DFND 1 3,033 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 23,092 1,871,352 SH   DFND 1 1,871,352 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 3,973 321,927 SH   OTR 2 321,927 0 0
SUMMIT MATLS INC CL A 86614U100 89,625 3,749,993 SH   DFND 1 3,749,993 0 0
SUMMIT MATLS INC CL A 86614U100 13,862 580,019 SH   OTR 2 580,019 0 0
SUN CMNTYS INC COM 866674104 638 4,249 SH   DFND 1 4,249 0 0
SUNCOR ENERGY INC NEW COM 867224107 62,729 1,912,472 SH   DFND 1 1,912,284 0 188
SUNNOVA ENERGY INTL INC COM 86745K104 4,248 380,617 SH   DFND 1 380,513 0 104
SUNRUN INC COM 86771W105 8,139 589,320 SH   DFND 1 589,183 0 137
SYNCHRONY FINL COM 87165B103 829 23,033 SH   DFND 1 23,033 0 0
SYNEOS HEALTH INC CL A 87166B102 28,710 482,717 SH   DFND 1 482,717 0 0
SYNEOS HEALTH INC CL A 87166B102 5,395 90,711 SH   OTR 2 90,711 0 0
TABULA RASA HEALTHCARE INC COM 873379101 30,936 635,503 SH   DFND 1 635,503 0 0
TABULA RASA HEALTHCARE INC COM 873379101 4,742 97,407 SH   OTR 2 97,407 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 21,923 377,335 SH   DFND 1 377,335 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 39,032 318,808 SH   DFND 1 317,651 0 1,157
TALLGRASS ENERGY LP CLASS A SHS 874696107 43,467 1,965,055 SH   DFND 1 1,965,055 0 0
TALLGRASS ENERGY LP CLASS A SHS 874696107 155 6,986 SH   OTR 2 6,986 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 26,735 448,498 SH   DFND 1 448,498 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 3,345 56,107 SH   OTR 2 56,107 0 0
TAPESTRY INC COM 876030107 4,187 155,254 SH   DFND 1 155,254 0 0
TARGA RES CORP COM 87612G101 89,646 2,195,593 SH   DFND 1 2,195,483 0 110
TAYLOR MORRISON HOME CORP COM 87724P106 848 38,791 SH   DFND 1 38,791 0 0
TC ENERGY CORP COM 87807B107 21,837 409,955 SH   DFND 1 409,955 0 0
TD AMERITRADE HLDG CORP COM 87236Y108 24,724 497,463 SH   DFND 1 495,914 0 1,549
TECH DATA CORP COM 878237106 639 4,447 SH   DFND 1 4,447 0 0
TECHNIPFMC PLC COM G87110105 18,622 868,549 SH   DFND 1 868,400 0 149
TEGNA INC COM 87901J105 1,179 70,626 SH   DFND 1 70,626 0 0
TELADOC HEALTH INC COM 87918A105 66,579 795,261 SH   DFND 1 794,230 0 1,031
TELADOC HEALTH INC COM 87918A105 6,885 82,237 SH   OTR 2 82,237 0 0
TELEFLEX INC COM 879369106 67,806 180,125 SH   DFND 1 179,709 0 416
TERRENO RLTY CORP COM 88146M101 645 11,907 SH   DFND 1 11,907 0 0
TESLA INC COM 88160R101 1,608,206 3,844,348 SH   DFND 1 3,662,138 0 182,210
TESLA INC COM 88160R101 28,253 67,538 SH   OTR 2 67,538 0 0
TEXAS INSTRS INC COM 882508104 135,597 1,056,955 SH   DFND 1 1,056,955 0 0
TEXAS ROADHOUSE INC COM 882681109 8,623 153,108 SH   DFND 1 153,108 0 0
TEXAS ROADHOUSE INC COM 882681109 3,125 55,482 SH   OTR 2 55,482 0 0
THE TRADE DESK INC COM CL A 88339J105 180,934 696,490 SH   DFND 1 630,513 0 65,977
THE TRADE DESK INC COM CL A 88339J105 19,112 73,569 SH   OTR 2 73,569 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 204,581 629,734 SH   DFND 1 586,746 0 42,988
THERMO FISHER SCIENTIFIC INC COM 883556102 21,059 64,822 SH   OTR 2 64,822 0 0
THERMON GROUP HLDGS INC COM 88362T103 9,075 338,605 SH   DFND 1 338,605 0 0
THERMON GROUP HLDGS INC COM 88362T103 3,731 139,231 SH   OTR 2 139,231 0 0
TJX COS INC NEW COM 872540109 1,945 31,861 SH   DFND 1 31,861 0 0
TOTAL S A SPONSORED ADS 89151E109 37,641 680,670 SH   DFND 1 680,581 0 89
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 27,864 1,158,093 SH   DFND 1 1,158,093 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 4,928 204,825 SH   OTR 2 204,825 0 0
TPI COMPOSITES INC COM 87266J104 3,052 164,872 SH   DFND 1 164,845 0 27
TRACTOR SUPPLY CO COM 892356106 13,604 145,590 SH   DFND 1 145,590 0 0
TREX CO INC COM 89531P105 11,097 123,464 SH   DFND 1 123,464 0 0
TREX CO INC COM 89531P105 3,977 44,243 SH   OTR 2 44,243 0 0
TRI POINTE GROUP INC COM 87265H109 899 57,697 SH   DFND 1 57,697 0 0
TRINITY INDS INC COM 896522109 16,381 739,536 SH   DFND 1 739,536 0 0
TRINITY INDS INC COM 896522109 3,830 172,912 SH   OTR 2 172,912 0 0
TRUIST FINL CORP COM 89832Q109 150,975 2,680,656 SH   DFND 1 2,680,656 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 32,619 523,659 SH   DFND 1 523,659 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,357 21,791 SH   OTR 2 21,791 0 0
TWILIO INC CL A 90138F102 422,824 4,302,243 SH   DFND 1 4,040,846 0 261,397
TWILIO INC CL A 90138F102 15,622 158,950 SH   OTR 2 158,950 0 0
TYLER TECHNOLOGIES INC COM 902252105 1,297 4,322 SH   DFND 1 4,322 0 0
U S SILICA HLDGS INC COM 90346E103 282 45,860 SH   DFND 1 45,860 0 0
UBER TECHNOLOGIES INC COM 90353T100 283,229 9,523,500 SH   DFND 1 8,847,481 0 676,019
UBER TECHNOLOGIES INC COM 90353T100 4,269 143,532 SH   OTR 2 143,532 0 0
ULTA BEAUTY INC COM 90384S303 11,823 46,706 SH   DFND 1 46,691 0 15
UNION PACIFIC CORP COM 907818108 873,550 4,831,847 SH   DFND 1 4,778,602 0 53,245
UNION PACIFIC CORP COM 907818108 9,536 52,746 SH   OTR 2 52,746 0 0
UNITED AIRLINES HLDGS INC COM 910047109 1,807 20,509 SH   DFND 1 20,509 0 0
UNITED RENTALS INC COM 911363109 71,699 429,928 SH   DFND 1 429,928 0 0
UNITED TECHNOLOGIES CORP COM 913017109 137,337 917,050 SH   DFND 1 917,050 0 0
UNITEDHEALTH GROUP INC COM 91324P102 88,921 302,472 SH   DFND 1 302,472 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 150,553 730,593 SH   DFND 1 699,810 0 30,783
UNIVERSAL DISPLAY CORP COM 91347P105 2,377 11,534 SH   OTR 2 11,534 0 0
UNIVERSAL FST PRODS INC COM 913543104 1,389 29,118 SH   DFND 1 29,118 0 0
UNIVERSAL INS HLDGS INC COM 91359V107 634 22,644 SH   DFND 1 22,644 0 0
US FOODS HLDG CORP COM 912008109 22,033 525,983 SH   DFND 1 524,062 0 1,921
VAIL RESORTS INC COM 91879Q109 66,037 275,349 SH   DFND 1 274,846 0 503
VALERO ENERGY CORP NEW COM 91913Y100 19,508 208,305 SH   DFND 1 208,253 0 52
VANGUARD INDEX FDS GROWTH ETF 922908736 270 1,484 SH   DFND 1 1,484 0 0
VARONIS SYS INC COM 922280102 22,814 293,578 SH   DFND 1 293,578 0 0
VARONIS SYS INC COM 922280102 8,310 106,940 SH   OTR 2 106,940 0 0
VERINT SYS INC COM 92343X100 4,275 77,218 SH   DFND 1 77,218 0 0
VERISK ANALYTICS INC COM 92345Y106 7,958 53,290 SH   DFND 1 53,088 0 202
VERIZON COMMUNICATIONS INC COM 92343V104 130,349 2,122,945 SH   DFND 1 2,122,945 0 0
VERRA MOBILITY CORP COM 92511U102 2,824 201,884 SH   DFND 1 201,884 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 773,759 3,533,953 SH   DFND 1 3,392,453 0 141,500
VERTEX PHARMACEUTICALS INC COM 92532F100 8,166 37,296 SH   OTR 2 37,296 0 0
VIACOMCBS INC CL B 92556H206 5,151 122,722 SH   DFND 1 122,722 0 0
VISA INC COM CL A 92826C839 2,646,262 14,083,351 SH   DFND 1 13,442,131 0 641,220
VISA INC COM CL A 92826C839 27,809 148,001 SH   OTR 2 148,001 0 0
VISHAY INTERTECHNOLOGY INC COM 928298108 1,171 55,008 SH   DFND 1 55,008 0 0
VMWARE INC CL A COM 928563402 1,242 8,180 SH   DFND 1 8,180 0 0
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 17,461 903,314 SH   DFND 1 903,314 0 0
VULCAN MATLS CO COM 929160109 24,383 169,337 SH   DFND 1 168,739 0 598
WABASH NATL CORP COM 929566107 555 37,762 SH   DFND 1 37,762 0 0
WALMART INC COM 931142103 228,924 1,926,322 SH   DFND 1 1,926,322 0 0
WASTE CONNECTIONS INC COM 94106B101 8,155 89,824 SH   DFND 1 89,824 0 0
WASTE MGMT INC DEL COM 94106L109 8,468 74,307 SH   DFND 1 74,307 0 0
WELBILT INC COM 949090104 13,862 888,049 SH   DFND 1 888,049 0 0
WELBILT INC COM 949090104 5,045 323,192 SH   OTR 2 323,192 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 4,605 13,947 SH   DFND 1 13,947 0 0
WELLS FARGO CO NEW COM 949746101 28,944 537,998 SH   DFND 1 537,998 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 620 4,123 SH   DFND 1 4,123 0 0
WESTERN DIGITAL CORP COM 958102105 471 7,415 SH   DFND 1 7,415 0 0
WESTERN MIDSTREAM PARTNERS L COM UNIT LP INT 958669103 4,264 216,561 SH   DFND 1 216,561 0 0
WESTERN UN CO COM 959802109 1,863 69,549 SH   DFND 1 69,549 0 0
WEYERHAEUSER CO COM 962166104 13,287 439,963 SH   DFND 1 439,899 0 64
WHEATON PRECIOUS METALS CORP COM 962879102 4,030 135,459 SH   DFND 1 135,423 0 36
WILLIAMS COS INC DEL COM 969457100 177,061 7,464,626 SH   DFND 1 7,464,626 0 0
WINGSTOP INC COM 974155103 15,621 181,145 SH   DFND 1 181,145 0 0
WINGSTOP INC COM 974155103 5,407 62,709 SH   OTR 2 62,709 0 0
WINNEBAGO INDS INC COM 974637100 720 13,583 SH   DFND 1 13,583 0 0
WINTRUST FINL CORP COM 97650W108 34,485 486,397 SH   DFND 1 486,397 0 0
WINTRUST FINL CORP COM 97650W108 7,172 101,150 SH   OTR 2 101,150 0 0
WORKDAY INC CL A 98138H101 890,456 5,414,756 SH   DFND 1 5,178,287 0 236,469
WORKDAY INC CL A 98138H101 7,645 46,486 SH   OTR 2 46,486 0 0
WPX ENERGY INC COM 98212B103 118,888 8,652,694 SH   DFND 1 8,652,216 0 478
WPX ENERGY INC COM 98212B103 10,606 771,910 SH   OTR 2 771,910 0 0
XCEL ENERGY INC COM 98389B100 53,935 849,508 SH   DFND 1 849,508 0 0
XENIA HOTELS & RESORTS INC COM 984017103 684 31,631 SH   DFND 1 31,631 0 0
XILINX INC COM 983919101 329,595 3,371,131 SH   DFND 1 3,221,549 0 149,582
XILINX INC COM 983919101 5,428 55,518 SH   OTR 2 55,518 0 0
ZAI LAB LTD ADR 98887Q104 10,637 255,759 SH   DFND 1 255,759 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 173,239 1,157,394 SH   DFND 1 1,157,394 0 0
ZOETIS INC CL A 98978V103 142,189 1,074,338 SH   DFND 1 1,018,774 0 55,564
ZYNGA INC CL A 98986T108 601 98,161 SH   DFND 1 98,161 0 0