The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 3,166 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
AC IMMUNE SA SHS H00263105 4,950 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 9,285 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ACCELERON PHARMA INC COM 00434H108 59,265 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 4,635 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ADURO BIOTECH INC COM 00739L101 1,060 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 2,307 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
AGENUS INC COM NEW 00847G705 6,450 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 12,960 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 1,666 425,000 SH   DFND 1,2,3,4,5,6 425,000 0 0
ALBIREO PHARMA INC COM 01345P106 9,004 450,200 SH   DFND 1,2,3,4,5,6 450,200 0 0
ALECTOR INC COM 014442107 3,245 225,000 SH   DFND 1,2,3,4,5,6 225,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 75,254 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 16,723 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 2,726 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 56,294 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 13,485 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 20,050 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 4,010 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
ARAVIVE INC COM 03890D108 3,000 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ARGENX SE SPONSORED ADR 04016X101 22,792 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ARQULE INC COM 04269E107 6,095 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 14,448 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 21,180 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 9,832 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 6,210 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AVANTOR INC COM 05352A100 88,200 6,000,000 SH   DFND 1,2,3,4,5,6 6,000,000 0 0
AVROBIO INC COM 05455M100 331 23,449 SH   DFND 1,2,3,4,5,6 23,449 0 0
AXCELLA HEALTH INC COM 05454B105 2,547 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
BANK AMER CORP COM 060505104 87,510 3,000,000 SH Call DFND 1,2,3,4,5,6 3,000,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 79,599 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BLUEBIRD BIO INC COM 09609G100 9,182 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 44,082 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 4,294 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 177,485 3,500,000 SH Call DFND 1,2,3,4,5,6 3,500,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,965 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 16,502 1,361,584 SH   DFND 1,2,3,4 1,361,584 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 16,970 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DELPHI TECHNOLOGIES PLC SHS G2709G107 10,050 750,000 SH Call DFND 1,2,3,4,5,6 750,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 6,128 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 14,360 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
DOUYU INTERNATIONAL HLDNGS L SPONSORED ADS 25985W105 3,276 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
EPIZYME INC COM 29428V104 15,473 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
FATE THERAPEUTICS INC COM 31189P102 31,060 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
FIBROGEN INC COM 31572Q808 6,656 180,000 SH   DFND 1,2,3,4,5,6 180,000 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 9,957 75,000 SH   DFND 1,2,3,4,5,6 75,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 16,982 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
GOSSAMER BIO INC COM 38341P102 6,716 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
GOSSAMER BIO INC COM 38341P102 20,299 1,208,968 SH   DFND 1,2,3,4 1,208,968 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 2,159 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
HOOKIPA PHARMA INC COM 43906K100 4,013 535,000 SH   DFND 1,2,3,4,5,6 535,000 0 0
HOOKIPA PHARMA INC COM 43906K100 4,497 599,616 SH   DFND 1,2,3,4 599,616 0 0
IGM BIOSCIENCES INC COM 449585108 3,550 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
INCYTE CORP COM 45337C102 18,558 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 12,740 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 949 110,532 SH   DFND 1,2,3,4 110,532 0 0
KALEIDO BIOSCIENCES INC COM 483347100 3,012 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
KALEIDO BIOSCIENCES INC COM 483347100 3,769 500,500 SH   DFND 1,2,3,4 500,500 0 0
KRYSTAL BIOTECH INC COM 501147102 5,209 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
KURA ONCOLOGY INC COM 50127T109 3,793 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 10,584 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 170,741 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
LIONS GATE ENTMNT CORP CL A VTG 535919401 4,625 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MEDICINES CO COM 584688105 70,000 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
MERUS N V COM N5749R100 8,910 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 7,750 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,582 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
MODERNA INC COM 60770K107 7,960 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MODERNA INC COM 60770K107 73,332 4,606,298 SH   DFND 1,2,3,4 4,606,298 0 0
MORGAN STANLEY COM NEW 617446448 64,005 1,500,000 SH Call DFND 1,2,3,4,5,6 1,500,000 0 0
MORPHIC HLDG INC COM 61775R105 9,055 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 23,890 1,319,186 SH   DFND 1,2,3,4 1,319,186 0 0
NEKTAR THERAPEUTICS COM 640268108 9,108 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
NEKTAR THERAPEUTICS COM 640268108 10,929 600,000 SH Call DFND 1,2,3,4,5,6 600,000 0 0
NIO INC SPONSORED ADS 62914V106 3,120 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
NIO INC SPONSORED ADS 62914V106 2,730 1,750,000 SH Call DFND 1,2,3,4,5,6 1,750,000 0 0
NVIDIA CORP COM 67066G104 34,814 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,158 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 7,488 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
THE REALREAL INC COM 88339P101 12,633 565,000 SH   DFND 1,2,3,4,5,6 565,000 0 0
REGENXBIO INC COM 75901B107 5,162 145,000 SH   DFND 1,2,3,4,5,6 145,000 0 0
REPLIMUNE GROUP INC COM 76029N106 8,340 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
RESTORBIO INC COM 76133L103 4,420 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 3,533 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 18,713 2,383,791 SH   DFND 1,2,3,4 2,383,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 21,044 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 3,665 405,000 SH   DFND 1,2,3,4,5,6 405,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 3,580 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 17,417 1,946,040 SH   DFND 1,2,3,4 1,946,040 0 0
SELECTA BIOSCIENCES INC COM 816212104 3,675 2,100,000 SH   DFND 1,2,3,4,5,6 2,100,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 17,578 1,700,000 SH   DFND 1,2,3,4,5,6 1,700,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 19,063 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 5,724 540,000 SH   DFND 1,2,3,4,5,6 540,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 6,689 308,526 SH   DFND 1,2,3,4,5,6 308,526 0 0
SQUARE INC CL A 852234103 1,859 30,000 SH   DFND 1,2,3,4,5,6 30,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,748 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
STONECO LTD COM CL A G85158106 10,434 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 7,092 471,846 SH   DFND 1,2,3,4,5,6 471,846 0 0
TG THERAPEUTICS INC COM 88322Q108 5,054 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
TRANSLATE BIO INC COM 89374L104 7,433 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TRICIDA INC COM 89610F101 11,113 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 15,040 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 2,388 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 15,235 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,408 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
WW INTL INC COM 98262P101 560,428 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
XENCOR INC COM 98401F105 10,119 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
Y MABS THERAPEUTICS INC COM 984241109 10,424 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 19,383 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0