The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 13,102 424,000 SH   SOLE   424,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 26,490 1,164,402 SH   SOLE   1,164,402 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 155,499 8,244,896 SH   SOLE   8,244,896 0 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 27,697 25,000,000 PRN   SOLE   25,000,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 113,826 1,162,200 SH   SOLE   1,162,200 0 0
ALLAKOS INC COM 01671P100 241,955 3,077,128 SH   SOLE   3,077,128 0 0
AMEDISYS INC COM 023436108 304 2,320 SH   SOLE   2,320 0 0
AMICUS THERAPEUTICS INC COM 03152W109 182,777 22,790,134 SH   SOLE   22,790,134 0 0
ANAPTYSBIO INC COM 032724106 21,433 612,558 SH   SOLE   612,558 0 0
ARGENX SE SPONSORED ADR 04016X101 123,126 1,080,432 SH   SOLE   1,080,432 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 63,818 4,519,717 SH   SOLE   4,519,717 0 0
ATRECA INC CL A COM 04965G109 13,943 1,139,106 SH   SOLE   1,139,106 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 83,221 2,962,655 SH   SOLE   2,962,655 0 0
AXONICS MODULATION TECH INC COM 05465P101 21,797 809,700 SH   SOLE   809,700 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 215 75,000 SH   SOLE   75,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 114,229 2,252,600 SH   SOLE   2,252,600 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 14 10,229 SH   SOLE   10,229 0 0
CELGENE CORP COM 151020104 55,876 562,700 SH   SOLE   562,700 0 0
CENTENE CORP DEL COM 15135B101 35,062 810,498 SH   SOLE   810,498 0 0
CHIMERIX INC COM 16934W106 7,604 3,235,795 SH   SOLE   3,235,795 0 0
CLOVIS ONCOLOGY INC COM 189464100 14,179 3,607,800 SH   SOLE   3,607,800 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 15,953 3,115,865 SH   SOLE   3,115,865 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 162,264 4,780,898 SH   SOLE   4,780,898 0 0
DEXCOM INC COM 252131107 45,393 304,158 SH   SOLE   304,158 0 0
EIDOS THERAPEUTICS INC COM 28249H104 33,200 923,003 SH   SOLE   923,003 0 0
ENDOLOGIX INC COM NEW 29266S304 313 78,755 SH   SOLE   78,755 0 0
EPIZYME INC COM 29428V104 89,090 8,636,933 SH   SOLE   8,636,933 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 189 10,000 SH   SOLE   10,000 0 0
FATE THERAPEUTICS INC COM 31189P102 174,197 11,216,809 SH   SOLE   11,216,809 0 0
FLEXION THERAPEUTICS INC COM 33938J106 296 21,630 SH   SOLE   21,630 0 0
FORTY SEVEN INC COM 34983P104 10,449 1,627,498 SH   SOLE   1,627,498 0 0
G1 THERAPEUTICS INC COM 3621LQ109 8,905 390,934 SH   SOLE   390,934 0 0
GENMAB A S SPONSORED ADS 372303206 25,297 1,248,600 SH   SOLE   1,248,600 0 0
GLYCOMIMETICS INC COM 38000Q102 8,610 1,997,647 SH   SOLE   1,997,647 0 0
GOSSAMER BIO INC COM 38341P102 4,374 260,500 SH   SOLE   260,500 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 26,807 3,104,494 SH   SOLE   3,104,494 0 0
HCA HEALTHCARE INC COM 40412C101 28,359 235,500 SH   SOLE   235,500 0 0
HOOKIPA PHARMA INC COM 43906K100 14,233 1,897,721 SH   SOLE   1,897,721 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 400 14,700 SH   SOLE   14,700 0 0
IGM BIOSCIENCES INC COM 449585108 55,806 3,144,000 SH   SOLE   3,144,000 0 0
IMMUNOGEN INC COM 45253H101 35,372 14,616,560 SH   SOLE   14,616,560 0 0
INSPIRE MED SYS INC COM 457730109 239 3,910 SH   SOLE   3,910 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 24,039 187,599 SH   SOLE   187,599 0 0
KRYSTAL BIOTECH INC COM 501147102 37,444 1,078,300 SH   SOLE   1,078,300 0 0
LHC GROUP INC COM 50187A107 246 2,166 SH   SOLE   2,166 0 0
LIVANOVA PLC SHS G5509L101 25,309 342,987 SH   SOLE   342,987 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 8,097 749,026 SH   SOLE   749,026 0 0
MYOKARDIA INC COM 62857M105 375 7,182 SH   SOLE   7,182 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 247 2,740 SH   SOLE   2,740 0 0
NEVRO CORP COM 64157F103 55,353 643,864 SH   SOLE   643,864 0 0
ODONATE THERAPEUTICS INC COM 676079106 20,136 773,571 SH   SOLE   773,571 0 0
OVID THERAPEUTICS INC COM 690469101 395 121,950 SH   SOLE   121,950 0 0
PENUMBRA INC COM 70975L107 40,074 297,972 SH   SOLE   297,972 0 0
PRA HEALTH SCIENCES INC COM 69354M108 39,236 395,400 SH   SOLE   395,400 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 22,310 790,006 SH   SOLE   790,006 0 0
REGENXBIO INC COM 75901B107 84,105 2,362,486 SH   SOLE   2,362,486 0 0
REPLIMUNE GROUP INC COM 76029N106 30,766 2,213,417 SH   SOLE   2,213,417 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 25,574 2,857,389 SH   SOLE   2,857,389 0 0
SMILEDIRECTCLUB INC CL A COM 83192H106 6,806 490,340 SH   SOLE   490,340 0 0
STEREOTAXIS INC COM NEW 85916J409 11,530 3,285,000 SH   SOLE   3,285,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 21,866 1,017,478 SH   SOLE   1,017,478 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 40,365 3,888,752 SH   SOLE   3,888,752 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 68,440 1,160,401 SH   SOLE   1,160,401 0 0
TCR2 THERAPEUTICS INC COM 87808K106 26,908 1,790,288 SH   SOLE   1,790,288 0 0
TRICIDA INC COM 89610F101 64,139 2,077,700 SH   SOLE   2,077,700 0 0
UNIQURE NV SHS N90064101 94,863 2,410,125 SH   SOLE   2,410,125 0 0
UNITEDHEALTH GROUP INC COM 91324P102 211 971 SH   SOLE   971 0 0
VAPOTHERM INC COM 922107107 9,087 959,539 SH   SOLE   959,539 0 0
VERICEL CORP COM 92346J108 253 16,720 SH   SOLE   16,720 0 0
VIKING THERAPEUTICS INC COM 92686J106 112 16,260 SH   SOLE   16,260 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 65,239 3,177,760 SH   SOLE   3,177,760 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 49,598 2,404,157 SH   SOLE   2,404,157 0 0
XENCOR INC COM 98401F105 29,670 879,627 SH   SOLE   879,627 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 29,496 3,000,641 SH   SOLE   3,000,641 0 0