The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 452 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 988 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 270 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 1,635 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 16,849 | 740,621 | SH | DFND | 1 | 740,621 | 0 | 0 | |
| ALLAKOS INC | COM | 01671P100 | 34,920 | 444,100 | SH | DFND | 1 | 444,100 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 20,193 | 1,332,000 | SH | DFND | 1 | 1,332,000 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 20,686 | 591,200 | SH | DFND | 1 | 591,200 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 71,692 | 2,976,000 | SH | DFND | 1 | 2,976,000 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 7,886 | 172,300 | SH | DFND | 1 | 172,300 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 14,599 | 128,110 | SH | DFND | 1 | 128,110 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 45,107 | 468,300 | SH | DFND | 1 | 468,300 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 24,080 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 4,236 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 4,971 | 406,142 | SH | DFND | 1 | 406,142 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 1,405 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 5,961 | 479,988 | SH | DFND | 1 | 479,988 | 0 | 0 | |
| AVROBIO INC | COM | 05455M100 | 8,024 | 568,294 | SH | DFND | 1 | 568,294 | 0 | 0 | |
| AXONICS MODULATION TECH INC | COM | 05465P101 | 32,914 | 1,222,671 | SH | DFND | 1 | 1,222,671 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 53,460 | 1,281,400 | SH | DFND | 1 | 1,281,400 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 25,032 | 600,000 | SH | Call | DFND | 1 | 600,000 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 36,221 | 493,000 | SH | DFND | 1 | 493,000 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 56,199 | 2,617,566 | SH | DFND | 1 | 2,617,566 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 12,340 | 1,820,000 | SH | DFND | 1 | 1,820,000 | 0 | 0 | |
| CONSTELLATION PHARMACEUTICAL I | COM | 210373106 | 7,838 | 1,213,274 | SH | DFND | 1 | 1,213,274 | 0 | 0 | |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 44,445 | 1,084,300 | SH | DFND | 1 | 1,084,300 | 0 | 0 | |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 26,762 | 788,500 | SH | DFND | 1 | 788,500 | 0 | 0 | |
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 19,448 | 540,686 | SH | DFND | 1 | 540,686 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 10,228 | 997,892 | SH | DFND | 1 | 997,892 | 0 | 0 | |
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 1,025 | 1,000 | SH | DFND | 1 | 1,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 22,854 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| GENFIT S A | ADS | 372279109 | 5,223 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 10,378 | 618,129 | SH | DFND | 1 | 618,129 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 8,879 | 649,994 | SH | DFND | 1 | 649,994 | 0 | 0 | |
| HEALTH SCIENCES ACQUISITN CORP | UNIT 04/01/2024 | 42227C201 | 11,588 | 1,080,000 | SH | DFND | 1 | 1,080,000 | 0 | 0 | |
| HOMOLOGY MEDICINES INC | COM | 438083107 | 4,436 | 245,100 | SH | DFND | 1 | 245,100 | 0 | 0 | |
| IGM BIOSCIENCES INC | COM | 449585108 | 2,776 | 156,400 | SH | DFND | 1 | 156,400 | 0 | 0 | |
| INFLARX NV | COM | N44821101 | 741 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| INSPIRE MED SYS INC | COM | 457730109 | 10,514 | 172,300 | SH | DFND | 1 | 172,300 | 0 | 0 | |
| ITERUM THERAPEUTICS PLC | SHS | G6333L101 | 2,339 | 396,385 | SH | DFND | 1 | 396,385 | 0 | 0 | |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 3,043 | 927,869 | SH | DFND | 1 | 927,869 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 18,682 | 1,231,500 | SH | DFND | 1 | 1,231,500 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 4,711 | 607,903 | SH | DFND | 1 | 607,903 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 124,656 | 1,600,000 | SH | DFND | 1 | 1,600,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 15,582 | 200,000 | SH | Call | DFND | 1 | 200,000 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 42,851 | 550,000 | SH | Put | DFND | 1 | 550,000 | 0 | 0 |
| MYOKARDIA INC | COM | 62857M105 | 23,102 | 443,000 | SH | DFND | 1 | 443,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 14,368 | 788,800 | SH | DFND | 1 | 788,800 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 3,541 | 39,300 | SH | DFND | 1 | 39,300 | 0 | 0 | |
| NEXTCURE INC | COM | 65343E108 | 27,290 | 884,600 | SH | DFND | 1 | 884,600 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 8,023 | 675,325 | SH | DFND | 1 | 675,325 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | COM NEW | 69012T206 | 23 | 15,753 | SH | DFND | 1 | 15,753 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 50 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 3,405 | 816,448 | SH | DFND | 1 | 816,448 | 0 | 0 | |
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 3,922 | 467,518 | SH | DFND | 1 | 467,518 | 0 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 37,895 | 1,341,896 | SH | DFND | 1 | 1,341,896 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 28,298 | 3,642,000 | SH | DFND | 1 | 3,642,000 | 0 | 0 | |
| RA PHARMACEUTICALS INC | COM | 74933V108 | 6,991 | 295,600 | SH | DFND | 1 | 295,600 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 65,819 | 819,769 | SH | DFND | 1 | 819,769 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 24,742 | 2,123,760 | SH | DFND | 1 | 2,123,760 | 0 | 0 | |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 | 3,860 | 491,700 | SH | DFND | 1 | 491,700 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 12,444 | 88,700 | SH | DFND | 1 | 88,700 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 16,698 | 221,700 | SH | DFND | 1 | 221,700 | 0 | 0 | |
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 12,884 | 858,382 | SH | DFND | 1 | 858,382 | 0 | 0 | |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,065 | 118,950 | SH | DFND | 1 | 118,950 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 118,708 | 400,000 | SH | Put | DFND | 1 | 400,000 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 38,433 | 1,788,394 | SH | DFND | 1 | 1,788,394 | 0 | 0 | |
| TRICIDA INC | COM | 89610F101 | 33,429 | 1,082,880 | SH | DFND | 1 | 1,082,880 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 133,155 | 3,541,367 | SH | DFND | 1 | 3,541,367 | 0 | 0 | |
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 16,409 | 687,149 | SH | DFND | 1 | 687,149 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 35,424 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 11,206 | 881,681 | SH | DFND | 1 | 881,681 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 30,500 | 400,000 | SH | Put | DFND | 1 | 400,000 | 0 | 0 |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 23,032 | 883,800 | SH | DFND | 1 | 883,800 | 0 | 0 | |
| ZAI LAB LTD | ADR | 98887Q104 | 8,966 | 277,161 | SH | DFND | 1 | 277,161 | 0 | 0 | |