The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 16,440 100,000 SH Put DFND   100,000 0 0
ADAMIS PHARMACEUTICALS CORP COM NEW 00547W208 1,366 1,938,825 SH   DFND   1,938,825 0 0
ADECOAGRO S A COM L00849106 1,749 300,000 SH   DFND   300,000 0 0
ADIENT PLC ORD SHS G0084W101 18,643 812,000 SH   DFND   812,000 0 0
ADMA BIOLOGICS INC COM 000899104 6,338 1,424,378 SH   DFND   1,424,378 0 0
AFFIMED N V COM N01045108 1,249 425,000 SH   DFND   425,000 0 0
AGILE THERAPEUTICS INC COM 00847L100 444 375,000 SH   DFND   375,000 0 0
AKAZOO SA SHS L0164E108 633 100,000 SH   DFND   100,000 0 0
AKAZOO SA *W EXP 09/11/202 L0164E116 385 500,000 SH   DFND   500,000 0 0
AKERNA CORP *W EXP 06/17/202 00973W110 55 75,000 SH   DFND   75,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 12,384 2,350,000 SH   DFND   2,350,000 0 0
ALLEGRO MERGER CORP *W EXP 01/06/202 01749N111 102 443,772 SH   DFND   443,772 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 28,469 354,000 SH   DFND   354,000 0 0
AMCI ACQUISITION CORP *W EXP 05/20/202 00165R119 70 200,000 SH   DFND   200,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,321 557,834 SH   DFND   557,834 0 0
ARDELYX INC COM 039697107 9,635 2,050,010 SH   DFND   2,050,010 0 0
ARYA SCIENCES ACQUISITION CO SHS CL A G3165V109 10,310 1,000,000 SH   DFND   1,000,000 0 0
ARYA SCIENCES ACQUISITION CO *W EXP 10/10/202 G3165V125 760 500,000 SH   DFND   500,000 0 0
AT HOME GROUP INC COM 04650Y100 23,569 2,450,000 SH   DFND   2,450,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 1,671 1,978,723 SH   DFND   1,978,723 0 0
AZURRX BIOPHARMA INC COM 05502L105 640 1,067,571 SH   DFND   1,067,571 0 0
BEYOND MEAT INC COM 08862E109 22,665 152,500 SH Call DFND   152,500 0 0
BIG ROCK PARTNERS ACQUISI CO *W EXP 12/01/202 089482111 14 82,500 SH   DFND   82,500 0 0
BIG ROCK PARTNERS ACQUISI CO RIGHT 12/01/2022 089482129 36 165,000 SH   DFND   165,000 0 0
BIOCERES CROP SOLUTIONS CORP *W EXP 03/14/202 G1117K106 68 200,000 SH   DFND   200,000 0 0
BONANZA CREEK ENERGY INC COM NEW 097793400 336 15,000 SH   DFND   15,000 0 0
CARDLYTICS INC COM 14161W105 12,569 375,000 SH   DFND   375,000 0 0
CARVANA CO CL A 146869102 118,800 1,800,000 SH   DFND   1,800,000 0 0
CHARDAN HEALTHCARE ACQUISITI COM 15957A108 1,391 136,995 SH   DFND   136,995 0 0
CHARDAN HEALTHCARE ACQUISITI *W EXP 12/13/202 15957A116 116 150,000 SH   DFND   150,000 0 0
CHASERG TECHNLGY ACQUISITN C *W EXP 04/10/202 16166A111 75 75,000 SH   DFND   75,000 0 0
CHIMERIX INC COM 16934W106 776 330,061 SH   DFND   330,061 0 0
COCA COLA CO COM 191216100 16,332 300,000 SH Put DFND   300,000 0 0
CONCRETE PUMPING HLDGS INC COM 206704108 783 197,245 SH   DFND   197,245 0 0
CONTRAFECT CORP COM 212326102 895 2,500,000 SH   DFND   2,500,000 0 0
CRESUD S A C I F Y A SPONSORED ADR 226406106 5,540 937,360 SH   DFND   937,360 0 0
CUE BIOPHARMA INC COM 22978P106 2,529 300,000 SH   DFND   300,000 0 0
DERMTECH INC *W EXP 08/29/202 24984K113 46 380,000 SH   DFND   380,000 0 0
DHT HOLDINGS INC SHS NEW Y2065G121 3,168 515,000 SH   DFND   515,000 0 0
DIAMOND S SHIPPING INC COM Y20676105 5,345 485,000 SH   DFND   485,000 0 0
DIANA SHIPPING INC COM Y2066G104 921 272,622 SH   DFND   272,622 0 0
EDTECHX HLDGS ACQUISITION CO *W EXP 12/31/202 28138X111 30 125,000 SH   DFND   125,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 19,071 1,860,529 SH   DFND   1,860,529 0 0
ENERGY RECOVERY INC COM 29270J100 8,987 970,000 SH   DFND   970,000 0 0
ENOVA INTL INC COM 29357K103 18,571 895,000 SH   DFND   895,000 0 0
ESTRE AMBIENTAL INC *W EXP 12/21/202 G3206V118 17 730,000 SH   DFND   730,000 0 0
FALCON MINERALS CORP *W EXP 07/21/202 30607B208 52 149,600 SH   DFND   149,600 0 0
FATE THERAPEUTICS INC COM 31189P102 3,494 225,000 SH   DFND   225,000 0 0
FENNEC PHARMACEUTICALS INC COM 31447P100 4,672 971,351 SH   DFND   971,351 0 0
FORTRESS BIOTECH INC COM 34960Q109 283 200,000 SH   DFND   200,000 0 0
FORUM MERGER II CORP *W EXP 09/30/202 34986F111 177 300,000 SH   DFND   300,000 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 6,483 1,356,356 SH   DFND   1,356,356 0 0
GENCO SHIPPING & TRADING LTD SHS Y2685T131 1,660 180,496 SH   DFND   180,496 0 0
GENERAL MLS INC COM 370334104 5,512 100,000 SH Put DFND   100,000 0 0
GENERAL MTRS CO COM 37045V100 28,110 750,000 SH Call DFND   750,000 0 0
GIGCAPITAL INC RIGHT 03/06/2020 37518N114 88 98,600 SH   DFND   98,600 0 0
GIGCAPITAL INC *W EXP 06/08/202 37518N122 102 150,000 SH   DFND   150,000 0 0
GLOBALSTAR INC COM 378973408 6,377 15,415,778 SH   DFND   15,415,778 0 0
GLOBALSTAR INC NOTE 5.750% 4/0 378973AD3 361 508,004 SH   DFND   508,004 0 0
GORDON POINTE ACQUISITION CO *W EXP 07/30/202 382788115 90 225,000 SH   DFND   225,000 0 0
GRAF INDL CORP *W EXP 12/31/202 384278115 88 225,000 SH   DFND   225,000 0 0
GREENLAND ACQUISITIN CORPORA *W EXP 03/03/202 G40981105 29 150,000 SH   DFND   150,000 0 0
GREENLAND ACQUISITIN CORPORA RIGHT 04/27/2025 G40981113 90 150,000 SH   DFND   150,000 0 0
GREIF INC CL B 397624206 543 11,910 SH   DFND   11,910 0 0
HEALTH SCIENCES ACQUSTN CORP COM 42227C102 8,016 800,000 SH   DFND   800,000 0 0
HEALTH SCIENCES ACQUSTN CORP *W EXP 04/01/202 42227C110 672 800,000 PRN   DFND   800,000 0 0
HERSHEY CO COM 427866108 54,247 350,000 SH Put DFND   350,000 0 0
HL ACQUISITIONS CORP *W EXP 06/21/202 G4603R122 47 180,000 SH   DFND   180,000 0 0
HL ACQUISITIONS CORP RIGHT 07/17/2023 G4603R130 49 180,000 SH   DFND   180,000 0 0
HOSTESS BRANDS INC *W EXP 11/04/202 44109J114 4,309 2,520,000 SH   DFND   2,520,000 0 0
IFRESH INC COM 449538107 56 30,000 SH   DFND   30,000 0 0
INSPIRED ENTMT INC COM 45782N108 5,764 801,824 SH   DFND   801,824 0 0
INTEL CORP COM 458140100 5,153 100,000 SH Put DFND   100,000 0 0
IRSA INVERSIONES Y REP S A GLOBL DEP RCPT 450047204 4,767 906,224 SH   DFND   906,224 0 0
IRSA PROPIEDADES COMERCIALES SPONSORED ADR 463588103 2,405 185,000 SH   DFND   185,000 0 0
JOHNSON & JOHNSON COM 478160104 3,235 25,000 SH   DFND   25,000 0 0
JOHNSON & JOHNSON COM 478160104 6,469 50,000 SH Put DFND   50,000 0 0
KADMON HLDGS INC COM 48283N106 844 334,900 SH   DFND   334,900 0 0
KROGER CO COM 501044101 12,890 500,000 SH Call DFND   500,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 176 150,142 SH   DFND   150,142 0 0
LEGACY ACQUISITION CORP *W EXP 11/30/202 524643111 175 500,000 SH   DFND   500,000 0 0
LEISURE ACQUISITION CORP *W EXP 12/05/201 52539T115 95 125,000 SH   DFND   125,000 0 0
LF CAP ACQUISITION CORP *W EXP 06/22/202 50200K116 185 450,000 SH   DFND   450,000 0 0
MACROGENICS INC COM 556099109 5,104 400,000 SH   DFND   400,000 0 0
MAIDEN HOLDINGS LTD SHS G5753U112 5,908 7,876,964 SH   DFND   7,876,964 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,695 1,100,000 SH   DFND   1,100,000 0 0
M D C HLDGS INC COM 552676108 4,310 100,000 SH Put DFND   100,000 0 0
MEGALITH FINL ACQUISITION CO *W EXP 08/26/202 58518F117 152 400,000 SH   DFND   400,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 6,380 400,000 SH   DFND   400,000 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 1,291 1,766,038 SH   DFND   1,766,038 0 0
MUDRICK CAP ACQUISITION CORP COM CLASS A 624745105 19,534 1,900,000 SH   DFND   1,900,000 0 0
MUDRICK CAP ACQUISITION CORP *W EXP 02/12/202 624745113 1,563 2,500,000 SH   DFND   2,500,000 0 0
MUSTANG BIO INC COM 62818Q104 2,038 625,000 SH   DFND   625,000 0 0
NATIONAL ENERGY SERVICES REU *W EXP 05/05/202 G6375R115 290 725,000 SH   DFND   725,000 0 0
NAVIOS MARITIME CONTAINERS L COM UNIT RP LP Y62151108 4,447 2,235,000 SH   DFND   2,235,000 0 0
NEW FRONTIER CORP *W EXP 99/99/999 G6485P124 50 50,000 SH   DFND   50,000 0 0
NII HLDGS INC COM PAR 62913F508 25,800 13,163,432 SH   DFND   13,163,432 0 0
NOVUS THERAPEUTICS INC COM 67011N105 386 623,102 SH   DFND   623,102 0 0
NRC GROUP HLDGS CORP *W EXP 10/17/202 629375114 1,269 537,500 SH   DFND   537,500 0 0
ON DECK CAP INC COM 682163100 12,517 3,725,000 SH   DFND   3,725,000 0 0
ONCONOVA THERAPEUTICS INC COM PAR 68232V405 476 560,000 SH   DFND   560,000 0 0
ONCOSEC MED INC COM 68234L306 370 188,000 SH   DFND   188,000 0 0
OPES ACQUISITION CORP *W EXP 03/13/202 68373P118 27 150,000 SH   DFND   150,000 0 0
ORACLE CORP COM 68389X105 22,012 400,000 SH Put DFND   400,000 0 0
ORISUN ACQUISITION CORP UNIT 99/99/9999 68632T208 500 50,000 SH   DFND   50,000 0 0
OTONOMY INC COM 68906L105 2,629 1,100,000 SH   DFND   1,100,000 0 0
PENN VA CORP NEW COM 70788V102 16,790 577,599 SH   DFND   577,599 0 0
PENSARE ACQUISITION CORP *W EXP 07/27/202 70957E113 27 115,000 SH   DFND   115,000 0 0
PENSARE ACQUISITION CORP RIGHT 99/99/9999 70957E121 181 605,000 SH   DFND   605,000 0 0
PEPSICO INC COM 713448108 13,710 100,000 SH Put DFND   100,000 0 0
PG&E CORP COM 69331C108 9,000 900,000 SH   DFND   900,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 512 150,257 SH   DFND   150,257 0 0
POLARITYTE INC COM 731094108 474 146,733 SH   DFND   146,733 0 0
PROCTER & GAMBLE CO COM 742718109 24,876 200,000 SH Put DFND   200,000 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 24,472 3,476,039 SH   DFND   3,476,039 0 0
SCHULTZE SPL PURP ACQUSTN CO *W EXP 12/31/202 80821R117 105 300,000 SH   DFND   300,000 0 0
SCORPIO TANKERS INC NOTE 3.000% 5/1 80918TAB5 2,127 2,000,000 SH   DFND   2,000,000 0 0
SCORPIO TANKERS INC SHS Y7542C130 5,568 187,100 SH   DFND   187,100 0 0
SEADRILL LTD COM G7998G106 1,317 627,302 SH   DFND   627,302 0 0
SELLAS LIFE SCIENCES GROUP I COM 81642T100 400 3,300,000 SH   DFND   3,300,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 1,279 3,274,953 SH   DFND   3,274,953 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 854 569,087 SH   DFND   569,087 0 0
SEQUENTIAL BRNDS GROUP INC N COM 81734P107 504 2,190,000 SH   DFND   2,190,000 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 2,208 923,700 SH   DFND   923,700 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 8,751 1,171,648 SH   DFND   1,171,648 0 0
SYNTHETIC BIOLOGICS INC COM NEW 87164U201 19 42,858 SH   DFND   42,858 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 4,461 429,775 SH   DFND   429,775 0 0
TEEKAY TANKERS LTD CL A Y8565N102 1,853 1,425,000 SH   DFND   1,425,000 0 0
TENZING ACQUISITION CORP *W EXP 02/23/202 G8708A108 40 200,000 SH   DFND   200,000 0 0
TESLA INC COM 88160R101 6,022 25,000 SH Call DFND   25,000 0 0
TESLA INC COM 88160R101 59,615 247,500 SH Put DFND   247,500 0 0
TG THERAPEUTICS INC COM 88322Q108 2,246 400,000 SH   DFND   400,000 0 0
TIBERIUS ACQUISITION CORP *W EXP 02/28/202 88633A115 266 450,000 PRN   DFND   450,000 0 0
TKK SYMPHONY ACQUISITION COR *W EXP 02/20/202 G88950129 20 225,000 SH   DFND   225,000 0 0
TKK SYMPHONY ACQUISITION COR RIGHT 02/20/2020 G88950137 54 225,000 SH   DFND   225,000 0 0
TOTTENHAM ACQUISITION I LTD *W EXP 05/06/202 G8959N114 92 542,000 SH   DFND   542,000 0 0
TOTTENHAM ACQUISITION I LTD RIGHT 06/05/2020 G8959N122 39 134,000 SH   DFND   134,000 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 1,161 2,597,680 SH   DFND   2,597,680 0 0
TRIDENT ACQUISITIONS CORP *W EXP 05/09/202 89615T114 299 1,993,750 SH   DFND   1,993,750 0 0
TRINITY MERGER CORP *W EXP 05/11/202 89653L114 889 700,000 SH   DFND   700,000 0 0
TRIVAGO N V SPON ADS A SHS 89686D105 12,829 3,121,334 SH   DFND   3,121,334 0 0
TWELVE SEAS INVESTMENT COMPA *W EXP 12/22/202 G9145A115 186 581,850 SH   DFND   581,850 0 0
TWELVE SEAS INVESTMENT COMPA RIGHT 12/22/2019 G9145A131 65 175,000 SH   DFND   175,000 0 0
UNIQURE NV SHS N90064101 22,435 570,000 SH   DFND   570,000 0 0
VBI VACCINES INC COM NEW 91822J103 942 2,000,000 SH   DFND   2,000,000 0 0
VECTOIQ ACQUISITION CORP *W EXP 05/11/202 92243N111 258 500,000 SH   DFND   500,000 0 0
WARRIOR MET COAL INC COM 93627C101 4,782 245,000 SH   DFND   245,000 0 0
XBIOTECH INC COM 98400H102 628 60,000 SH   DFND   60,000 0 0
ZAFGEN INC COM 98885E103 1,723 2,331,413 SH   DFND   2,331,413 0 0
ZIOPHARM ONCOLOGY INC COM 98973P101 428 100,000 SH   DFND   100,000 0 0
ZOGENIX INC COM NEW 98978L204 2,002 50,000 SH   DFND   50,000 0 0