The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 3,844 200,000 SH Call DFND 1,2,3,4 200,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 15,578 810,488 SH   DFND 1,2,3,4 810,488 0 0
AKAZOO SA SHS L0164E108 2,036 321,600 SH   DFND 1,2,3,4 321,600 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 22,469 134,360 SH   DFND 1,2,3,4 134,360 0 0
ALLERGAN PLC SHS G0177J108 10,134 60,216 SH   DFND 1,2,3,4 60,216 0 0
ALPHABET INC CAP STK CL A 02079K305 31,416 25,727 SH   DFND 1,2,3,4 25,727 0 0
AMAZON COM INC COM 023135106 17,081 9,840 SH   DFND 1,2,3,4 9,840 0 0
ARAMARK COM 03852U106 26,382 605,371 SH   DFND 1,2,3,4 605,371 0 0
ARGENX SE SPONSORED ADR 04016X101 21,041 184,631 SH   DFND 1,2,3,4 184,631 0 0
ARQULE INC COM 04269E107 717 100,000 SH Call DFND 1,2,3,4 100,000 0 0
ARQULE INC COM 04269E107 8,399 1,171,352 SH   DFND 1,2,3,4 1,171,352 0 0
ATHENEX INC COM 04685N103 6,525 536,373 SH   DFND 1,2,3,4 536,373 0 0
AXSOME THERAPEUTICS INC COM 05464T104 3,036 150,000 SH Put DFND 1,2,3,4 150,000 0 0
BEYOND AIR INC COM 08862L103 1,844 400,859 SH   DFND 1,2,3,4 400,859 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,172 100,000 SH Call DFND 1,2,3,4 100,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 48,261 1,156,774 SH   DFND 1,2,3,4 1,156,774 0 0
CANADIAN PAC RY LTD COM 13645T100 15,147 68,088 SH   DFND 1,2,3,4 68,088 0 0
CARA THERAPEUTICS INC COM 140755109 5,151 281,808 SH   DFND 1,2,3,4 281,808 0 0
CONSTELLIUM SE CL A N22035104 26,274 2,067,180 SH   DFND 1,2,3,4 2,067,180 0 0
CROWN HOLDINGS INC COM 228368106 25,805 390,623 SH   DFND 1,2,3,4 390,623 0 0
DISNEY WALT CO COM DISNEY 254687106 8,356 64,122 SH   DFND 1,2,3,4 64,122 0 0
DISNEY WALT CO COM DISNEY 254687106 13,032 100,000 SH Call DFND 1,2,3,4 100,000 0 0
ELDORADO RESORTS INC COM 28470R102 26,131 655,401 SH   DFND 1,2,3,4 655,401 0 0
FACEBOOK INC CL A 30303M102 15,902 89,296 SH   DFND 1,2,3,4 89,296 0 0
FACEBOOK INC CL A 30303M102 17,808 100,000 SH Call DFND 1,2,3,4 100,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 13,485 983,924 SH   DFND 1,2,3,4 983,924 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,990 686,222 SH   DFND 1,2,3,4 686,222 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 4,650 1,267,030 SH   DFND 1,2,3,4 1,267,030 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 7,524 1,200,000 SH   DFND 1,2,3,4 1,200,000 0 0
HERON THERAPEUTICS INC COM 427746102 9,356 505,729 SH   DFND 1,2,3,4 505,729 0 0
HUYA INC ADS REP SHS A 44852D108 15,265 645,738 SH   DFND 1,2,3,4 645,738 0 0
IAA INC COM 449253103 12,053 288,838 SH   DFND 1,2,3,4 288,838 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 747 100,000 SH Call DFND 1,2,3,4 100,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 25,961 137,500 SH Put DFND 1,2,3,4 137,500 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 21,188 140,000 SH Put DFND 1,2,3,4 140,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 1,263 3,000,000 PRN   DFND 1,2,3,4 3,000,000 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 5,984 327,277 SH   DFND 1,2,3,4 327,277 0 0
MARATHON PETE CORP COM 56585A102 30,641 504,377 SH   DFND 1,2,3,4 504,377 0 0
MEDIFAST INC COM 58470H101 13,571 130,956 SH   DFND 1,2,3,4 130,956 0 0
MICROSOFT CORP COM 594918104 30,234 217,467 SH   DFND 1,2,3,4 217,467 0 0
MOLECULAR TEMPLATES INC COM 608550109 3,569 541,565 SH   DFND 1,2,3,4 541,565 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 20,861 122,414 SH   DFND 1,2,3,4 122,414 0 0
NEW ORIENTAL ED & TECH GRP I SPON ADR 647581107 16,281 146,996 SH   DFND 1,2,3,4 146,996 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 12,421 605,919 SH   DFND 1,2,3,4 605,919 0 0
PRETIUM RES INC COM 74139C102 3,453 300,000 SH   DFND 1,2,3,4 300,000 0 0
PTC THERAPEUTICS INC COM 69366J200 6,193 183,119 SH   DFND 1,2,3,4 183,119 0 0
RAPID7 INC COM 753422104 13,366 294,469 SH   DFND 1,2,3,4 294,469 0 0
REGENERON PHARMACEUTICALS COM 75886F107 17,328 62,465 SH   DFND 1,2,3,4 62,465 0 0
SALESFORCE COM INC COM 79466L302 14,106 95,029 SH   DFND 1,2,3,4 95,029 0 0
SEATTLE GENETICS INC COM 812578102 8,540 100,000 SH Put DFND 1,2,3,4 100,000 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 602 9,800 SH   DFND 1,2,3,4 9,800 0 0
SESEN BIO INC COM 817763105 7,202 6,155,323 SH   DFND 1,2,3,4 6,155,323 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 5,137 571,382 SH   DFND 1,2,3,4 571,382 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 73,005 246,000 SH Put DFND 1,2,3,4 246,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 12,200 160,000 SH Put DFND 1,2,3,4 160,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 2,381 398,169 SH   DFND 1,2,3,4 398,169 0 0
TRILOGY METALS INC NEW COM 89621C105 2,406 1,449,446 SH   DFND 1,2,3,4 1,449,446 0 0
UNION PACIFIC CORP COM 907818108 16,695 103,067 SH   DFND 1,2,3,4 103,067 0 0
UNITED PARCEL SERVICE INC CL B 911312106 15,709 131,108 SH   DFND 1,2,3,4 131,108 0 0
WILLSCOT CORP COM 971375126 11,394 731,300 SH   DFND 1,2,3,4 731,300 0 0
ZEBRA TECHNOLOGIES CORP CL A 989207105 13,287 64,382 SH   DFND 1,2,3,4 64,382 0 0