The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 20,528 425,000 SH   SOLE   425,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 264 22,236 SH   SOLE   22,236 0 0
AKERO THERAPEUTICS INC COM 00973Y108 22,383 1,168,802 SH   SOLE   1,168,802 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 97,042 8,244,896 SH   SOLE   8,244,896 0 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 23,197 25,000,000 PRN   SOLE   25,000,000 0 0
ALLAKOS INC COM 01671P100 99,672 2,300,301 SH   SOLE   2,300,301 0 0
AMEDISYS INC COM 023436108 282 2,320 SH   SOLE   2,320 0 0
AMICUS THERAPEUTICS INC COM 03152W109 284,452 22,792,634 SH   SOLE   22,792,634 0 0
ANAPTYSBIO INC COM 032724106 34,397 609,658 SH   SOLE   609,658 0 0
ANTHEM INC COM 036752103 51,786 183,500 SH   SOLE   183,500 0 0
ARGENX SE SPONSORED ADR 04016X101 151,325 1,068,832 SH   SOLE   1,068,832 0 0
ARRAY BIOPHARMA INC COM 04269X105 405,492 8,752,254 SH   SOLE   8,752,254 0 0
ARRAY BIOPHARMA INC NOTE 2.625%12/0 04269XAB1 50,155 16,500,000 PRN   SOLE   16,500,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 92,524 4,600,917 SH   SOLE   4,600,917 0 0
ATRECA INC CL A COM 04965G109 21,483 1,140,306 SH   SOLE   1,140,306 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 112,526 2,972,167 SH   SOLE   2,972,167 0 0
AVEDRO INC COM 05355N109 4,246 216,200 SH   SOLE   216,200 0 0
AXONICS MODULATION TECH INC COM 05465P101 33,329 813,500 SH   SOLE   813,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 4,946 39,900 SH   SOLE   39,900 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,324 97,191 SH   SOLE   97,191 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,565 100,000 SH Call SOLE   100,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 75,707 1,669,400 SH   SOLE   1,669,400 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 33 10,229 SH   SOLE   10,229 0 0
CELGENE CORP COM 151020104 51,489 557,000 SH   SOLE   557,000 0 0
CENTENE CORP DEL COM 15135B101 36,229 690,870 SH   SOLE   690,870 0 0
CHIMERIX INC COM 16934W106 15,372 3,558,388 SH   SOLE   3,558,388 0 0
CLOVIS ONCOLOGY INC COM 189464100 51,484 3,462,300 SH   SOLE   3,462,300 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 22,471 3,138,365 SH   SOLE   3,138,365 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 50,137 2,223,376 SH   SOLE   2,223,376 0 0
DEXCOM INC COM 252131107 25,787 172,100 SH   SOLE   172,100 0 0
EHEALTH INC COM 28238P109 76,518 888,705 SH   SOLE   888,705 0 0
EIDOS THERAPEUTICS INC COM 28249H104 27,301 878,403 SH   SOLE   878,403 0 0
ENDOLOGIX INC COM NEW 29266S304 570 78,755 SH   SOLE   78,755 0 0
EPIZYME INC COM 29428V104 109,551 8,729,142 SH   SOLE   8,729,142 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 220 10,000 SH   SOLE   10,000 0 0
FATE THERAPEUTICS INC COM 31189P102 210,301 10,359,666 SH   SOLE   10,359,666 0 0
FLEXION THERAPEUTICS INC COM 33938J106 266 21,630 SH   SOLE   21,630 0 0
FORTY SEVEN INC COM 34983P104 2,480 234,000 SH   SOLE   234,000 0 0
G1 THERAPEUTICS INC COM 3621LQ109 8,975 292,734 SH   SOLE   292,734 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 9,889 188,000 SH   SOLE   188,000 0 0
GLYCOMIMETICS INC COM 38000Q102 23,941 2,008,447 SH   SOLE   2,008,447 0 0
GOSSAMER BIO INC COM 38341P102 5,514 248,600 SH   SOLE   248,600 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 35,826 3,215,994 SH   SOLE   3,215,994 0 0
HOOKIPA PHARMA INC COM 43906K100 12,732 1,891,879 SH   SOLE   1,891,879 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 274 11,400 SH   SOLE   11,400 0 0
IMMUNOGEN INC COM 45253H101 30,282 13,954,794 SH   SOLE   13,954,794 0 0
INVITAE CORP COM 46185L103 8,821 375,375 SH   SOLE   375,375 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 24,005 168,387 SH   SOLE   168,387 0 0
JOUNCE THERAPEUTICS INC COM 481116101 1,260 254,590 SH   SOLE   254,590 0 0
KRYSTAL BIOTECH INC COM 501147102 43,504 1,080,300 SH   SOLE   1,080,300 0 0
LHC GROUP INC COM 50187A107 259 2,166 SH   SOLE   2,166 0 0
LIVANOVA PLC SHS G5509L101 30,510 423,987 SH   SOLE   423,987 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 10,594 814,898 SH   SOLE   814,898 0 0
MORPHOSYS AG SPONSORED ADS 617760202 17,711 733,699 SH   SOLE   733,699 0 0
MYOKARDIA INC COM 62857M105 313 6,252 SH   SOLE   6,252 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 231 2,740 SH   SOLE   2,740 0 0
NEVRO CORP COM 64157F103 220 3,400 SH   SOLE   3,400 0 0
ODONATE THERAPEUTICS INC COM 676079106 27,175 740,671 SH   SOLE   740,671 0 0
OVID THERAPEUTICS INC COM 690469101 1,364 737,550 SH   SOLE   737,550 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 24,720 1,796,477 SH   SOLE   1,796,477 0 0
PERSONALIS INC COM 71535D106 10,860 400,000 SH   SOLE   400,000 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 8,102 244,100 SH   SOLE   244,100 0 0
REGENXBIO INC COM 75901B107 71,475 1,391,376 SH   SOLE   1,391,376 0 0
REPLIMUNE GROUP INC COM 76029N106 32,208 2,197,003 SH   SOLE   2,197,003 0 0
SAREPTA THERAPEUTICS INC COM 803607100 62,603 412,000 SH   SOLE   412,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 46,317 2,920,389 SH   SOLE   2,920,389 0 0
STOKE THERAPEUTICS INC COM 86150R107 29,806 1,021,808 SH   SOLE   1,021,808 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 33,525 3,620,376 SH   SOLE   3,620,376 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 75,232 1,166,032 SH   SOLE   1,166,032 0 0
TCR2 THERAPEUTICS INC COM 87808K106 25,747 1,799,216 SH   SOLE   1,799,216 0 0
TELADOC HEALTH INC COM 87918A105 30,673 461,880 SH   SOLE   461,880 0 0
TRICIDA INC COM 89610F101 76,758 1,945,200 SH   SOLE   1,945,200 0 0
UNIQURE NV SHS N90064101 130,473 1,669,525 SH   SOLE   1,669,525 0 0
UNITEDHEALTH GROUP INC COM 91324P102 34,625 141,901 SH   SOLE   141,901 0 0
VAPOTHERM INC COM 922107107 22,069 959,539 SH   SOLE   959,539 0 0
VERICEL CORP COM 92346J108 316 16,720 SH   SOLE   16,720 0 0
VIKING THERAPEUTICS INC COM 92686J106 135 16,260 SH   SOLE   16,260 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 70,957 2,719,707 SH   SOLE   2,719,707 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 70,738 2,372,157 SH   SOLE   2,372,157 0 0
XENCOR INC COM 98401F105 66,012 1,612,798 SH   SOLE   1,612,798 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 34,327 3,000,641 SH   SOLE   3,000,641 0 0