The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 4,186 1,911,573 SH   SOLE   1,911,573 0 0
Amarin ADR 023111206 100,989 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc COMM 03753U106 1,256 49,580 SH   SOLE   49,580 0 0
Ascendis Pharma A/S ADR 04351P101 126,645 1,099,824 SH   SOLE   1,099,824 0 0
Audentes Therapeutics COMM 05070R104 35,348 933,640 SH   SOLE   933,640 0 0
Chiasma COMM 16706W102 12,178 1,630,221 SH   SOLE   1,630,221 0 0
Coherus BioSciences COMM 19249H103 46,260 2,093,221 SH   SOLE   2,093,221 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 7,612 1,180,178 SH   SOLE   1,180,178 0 0
Iterum Therapeutics COMM G6333L101 11,878 1,726,514 SH   SOLE   1,726,514 0 0
Karuna Therapeutics, Inc. COMM 48576A100 34,622 1,729,352 SH   SOLE   1,729,352 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 12,493 922,700 SH   SOLE   922,700 0 0
Merus N.V. COMM N5749R100 28,729 1,961,039 SH   SOLE   1,961,039 0 0
Natera COMM 632307104 85,513 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 37,777 2,521,856 SH   SOLE   2,521,856 0 0
Nucana Biomed Ltd ADR 67022C106 23,528 2,266,666 SH   SOLE   2,266,666 0 0
Nucana Biomed Ltd Ordinary Shares GB00BYWYV 24,912 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 53,718 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 854 142,635 SH   SOLE   142,635 0 0
Principia Biopharma COMM 74257L108 67,648 2,038,208 SH   SOLE   2,038,208 0 0
Spark Therapeutics COMM 84652J103 49,272 481,270 SH   SOLE   481,270 0 0
Synlogic Inc. COMM 87166L100 5,232 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 48,125 2,104,278 SH   SOLE   2,104,278 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 1,493 55,850 SH   SOLE   55,850 0 0
AbbVie Inc COMM 00287Y109 753 10,352 SH   SOLE   10,352 0 0
Acceleron Pharma Inc COMM 00434H108 3,570 86,908 SH   SOLE   86,908 0 0
Acorda Therapeutics Inc COMM 00484M106 537 70,066 SH   SOLE   70,066 0 0
Adverum Biotechnologies Inc COMM 00773U108 802 67,444 SH   SOLE   67,444 0 0
Akebia Therapeutics Inc COMM 00972D105 1,475 304,787 SH   SOLE   304,787 0 0
Allergan plc COMM G0177J108 5,103 30,481 SH   SOLE   30,481 0 0
Allergan plc COMM G0177J908 3,014 18,000 SH Call SOLE   18,000 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q107 725 9,994 SH   SOLE   9,994 0 0
Amgen Inc COMM 031162950 3,317 18,000 SH Put SOLE   18,000 0 0
Amicus Therapeutics Inc COMM 03152W109 3,032 242,971 SH   SOLE   242,971 0 0
Applied Therapeutics Inc COMM 03828A101 415 50,350 SH   SOLE   50,350 0 0
ArQule Inc COMM 04269E107 1,114 101,215 SH   SOLE   101,215 0 0
Autolus Therapeutics PLC ADR 05280R100 380 23,616 SH   SOLE   23,616 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 583 153,942 SH   SOLE   153,942 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 2,572 30,029 SH   SOLE   30,029 0 0
Bristol-Myers Squibb Co COMM 110122908 1,628 35,900 SH Call SOLE   35,900 0 0
Bristol-Myers Squibb Co COMM 110122108 2,828 62,368 SH   SOLE   62,368 0 0
Calithera Biosciences Inc COMM 13089P101 741 190,075 SH   SOLE   190,075 0 0
Clovis Oncology Inc COMM 189464100 669 44,966 SH   SOLE   44,966 0 0
Deciphera Pharmaceuticals Inc COMM 24344T951 810 35,900 SH Put SOLE   35,900 0 0
Dermira Inc COMM 24983L104 2,263 236,746 SH   SOLE   236,746 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 973 408,895 SH   SOLE   408,895 0 0
Forty Seven Inc COMM 34983P104 452 42,665 SH   SOLE   42,665 0 0
Halozyme Therapeutics Inc COMM 40637H109 4,200 244,475 SH   SOLE   244,475 0 0
Heron Therapeutics Inc COMM 427746102 4,134 222,360 SH   SOLE   222,360 0 0
Incyte Corp COMM 45337C102 2,124 24,998 SH   SOLE   24,998 0 0
Intra-Cellular Therapies Inc COMM 46116X901 819 63,100 SH Call SOLE   63,100 0 0
Intra-Cellular Therapies Inc COMM 46116X101 588 45,291 SH   SOLE   45,291 0 0
Kadmon Holdings Inc COMM 48283N106 1,601 777,390 SH   SOLE   777,390 0 0
Kala Pharmaceuticals Inc COMM 483119103 671 105,105 SH   SOLE   105,105 0 0
MacroGenics Inc COMM 556099109 3,360 197,969 SH   SOLE   197,969 0 0
MorphoSys AG COMM D55040105 3,315 34,528 SH   SOLE   34,528 0 0
Neurocrine Biosciences Inc COMM 64125C109 4,721 55,921 SH   SOLE   55,921 0 0
Novo Nordisk A/S ADR 670100205 5,931 116,204 SH   SOLE   116,204 0 0
Orchard Therapeutics PLC ADR 68570P101 1,795 128,298 SH   SOLE   128,298 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 707 186,030 SH   SOLE   186,030 0 0
Otonomy Inc COMM 68906L105 1,287 467,940 SH   SOLE   467,940 0 0
PTC Therapeutics Inc COMM 69366J200 5,984 132,983 SH   SOLE   132,983 0 0
Reata Pharmaceuticals Inc COMM 75615P103 3,931 41,660 SH   SOLE   41,660 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 812 87,170 SH   SOLE   87,170 0 0
TG Therapeutics Inc COMM 88322Q108 3,924 453,638 SH   SOLE   453,638 0 0
Uniqure NV COMM N90064101 1,407 18,000 SH Call SOLE   18,000 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 3,265 17,803 SH   SOLE   17,803 0 0
XBiotech Inc COMM 98400H102 903 119,117 SH   SOLE   119,117 0 0
Zogenix Inc COMM 98978L904 865 18,100 SH Call SOLE   18,100 0 0
Zymeworks Inc COMM 98985W102 1,484 67,470 SH   SOLE   67,470 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 888 33,222 SH   OTR 1 33,222 0 0
AbbVie Inc COMM 00287Y109 449 6,168 SH   OTR 1 6,168 0 0
Acceleron Pharma Inc COMM 00434H108 2,126 51,752 SH   OTR 1 51,752 0 0
Acorda Therapeutics Inc COMM 00484M106 319 41,539 SH   OTR 1 41,539 0 0
Adverum Biotechnologies Inc COMM 00773U108 478 40,162 SH   OTR 1 40,162 0 0
Akebia Therapeutics Inc COMM 00972D105 878 181,392 SH   OTR 1 181,392 0 0
Allergan plc COMM G0177J108 3,026 18,076 SH   OTR 1 18,076 0 0
Allergan plc COMM G0177J908 1,792 10,700 SH Call OTR 1 10,700 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q107 432 5,952 SH   OTR 1 5,952 0 0
Amgen Inc COMM 031162950 1,953 10,600 SH Put OTR 1 10,600 0 0
Amicus Therapeutics Inc COMM 03152W109 1,811 145,118 SH   OTR 1 145,118 0 0
Applied Therapeutics Inc COMM 03828A101 250 30,324 SH   OTR 1 30,324 0 0
ArQule Inc COMM 04269E107 663 60,239 SH   OTR 1 60,239 0 0
Autolus Therapeutics PLC ADR 05280R100 227 14,104 SH   OTR 1 14,104 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 346 91,299 SH   OTR 1 91,299 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 1,552 18,115 SH   OTR 1 18,115 0 0
Bristol-Myers Squibb Co COMM 110122908 970 21,400 SH Call OTR 1 21,400 0 0
Bristol-Myers Squibb Co COMM 110122108 1,683 37,113 SH   OTR 1 37,113 0 0
Calithera Biosciences Inc COMM 13089P101 441 113,008 SH   OTR 1 113,008 0 0
Clovis Oncology Inc COMM 189464100 398 26,761 SH   OTR 1 26,761 0 0
Deciphera Pharmaceuticals Inc COMM 24344T951 483 21,400 SH Put OTR 1 21,400 0 0
Dermira Inc COMM 24983L104 1,348 140,956 SH   OTR 1 140,956 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 549 230,742 SH   OTR 1 230,742 0 0
Forty Seven Inc COMM 34983P104 269 25,364 SH   OTR 1 25,364 0 0
Halozyme Therapeutics Inc COMM 40637H109 2,532 147,379 SH   OTR 1 147,379 0 0
Heron Therapeutics Inc COMM 427746102 2,461 132,387 SH   OTR 1 132,387 0 0
Incyte Corp COMM 45337C102 1,264 14,878 SH   OTR 1 14,878 0 0
Intra-Cellular Therapies Inc COMM 46116X901 488 37,600 SH Call OTR 1 37,600 0 0
Intra-Cellular Therapies Inc COMM 46116X101 350 26,970 SH   OTR 1 26,970 0 0
Kadmon Holdings Inc COMM 48283N106 966 468,954 SH   OTR 1 468,954 0 0
Kala Pharmaceuticals Inc COMM 483119103 406 63,588 SH   OTR 1 63,588 0 0
MacroGenics Inc COMM 556099109 1,999 117,813 SH   OTR 1 117,813 0 0
MorphoSys AG COMM D55040105 1,973 20,546 SH   OTR 1 20,546 0 0
Neurocrine Biosciences Inc COMM 64125C109 2,812 33,301 SH   OTR 1 33,301 0 0
Novo Nordisk A/S ADR 670100205 3,528 69,122 SH   OTR 1 69,122 0 0
Orchard Therapeutics PLC ADR 68570P101 1,110 79,372 SH   OTR 1 79,372 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 426 112,146 SH   OTR 1 112,146 0 0
Otonomy Inc COMM 68906L105 781 283,853 SH   OTR 1 283,853 0 0
PTC Therapeutics Inc COMM 69366J200 3,564 79,193 SH   OTR 1 79,193 0 0
Reata Pharmaceuticals Inc COMM 75615P103 2,341 24,809 SH   OTR 1 24,809 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 483 51,880 SH   OTR 1 51,880 0 0
TG Therapeutics Inc COMM 88322Q108 2,335 269,999 SH   OTR 1 269,999 0 0
Uniqure NV COMM N90064101 836 10,700 SH Call OTR 1 10,700 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 1,970 10,742 SH   OTR 1 10,742 0 0
XBiotech Inc COMM 98400H102 537 70,855 SH   OTR 1 70,855 0 0
Zogenix Inc COMM 98978L904 511 10,700 SH Call OTR 1 10,700 0 0
Zymeworks Inc COMM 98985W102 884 40,170 SH   OTR 1 40,170 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 1,778 66,504 SH   OTR 2 66,504 0 0
AbbVie Inc COMM 00287Y109 901 12,391 SH   OTR 2 12,391 0 0
Acceleron Pharma Inc COMM 00434H108 4,206 102,383 SH   OTR 2 102,383 0 0
Acorda Therapeutics Inc COMM 00484M106 632 82,431 SH   OTR 2 82,431 0 0
Adverum Biotechnologies Inc COMM 00773U108 945 79,453 SH   OTR 2 79,453 0 0
Akebia Therapeutics Inc COMM 00972D105 1,753 362,177 SH   OTR 2 362,177 0 0
Allergan plc COMM G0177J108 6,007 35,876 SH   OTR 2 35,876 0 0
Allergan plc COMM G0177J908 3,566 21,300 SH Call OTR 2 21,300 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q107 860 11,846 SH   OTR 2 11,846 0 0
Amgen Inc COMM 031162950 3,944 21,400 SH Put OTR 2 21,400 0 0
Amicus Therapeutics Inc COMM 03152W109 2,436 195,220 SH   OTR 2 195,220 0 0
Applied Therapeutics Inc COMM 03828A101 505 61,330 SH   OTR 2 61,330 0 0
ArQule Inc COMM 04269E107 1,326 120,403 SH   OTR 2 120,403 0 0
Autolus Therapeutics PLC ADR 05280R100 452 28,060 SH   OTR 2 28,060 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 687 181,159 SH   OTR 2 181,159 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 3,148 36,752 SH   OTR 2 36,752 0 0
Bristol-Myers Squibb Co COMM 110122908 1,936 42,700 SH Call OTR 2 42,700 0 0
Bristol-Myers Squibb Co COMM 110122108 3,373 74,368 SH   OTR 2 74,368 0 0
Calithera Biosciences Inc COMM 13089P101 884 226,756 SH   OTR 2 226,756 0 0
Clovis Oncology Inc COMM 189464100 797 53,576 SH   OTR 2 53,576 0 0
Deciphera Pharmaceuticals Inc COMM 24344T951 965 42,800 SH Put OTR 2 42,800 0 0
Dermira Inc COMM 24983L104 2,698 282,180 SH   OTR 2 282,180 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,133 476,173 SH   OTR 2 476,173 0 0
Forty Seven Inc COMM 34983P104 538 50,774 SH   OTR 2 50,774 0 0
Halozyme Therapeutics Inc COMM 40637H109 5,126 298,345 SH   OTR 2 298,345 0 0
Heron Therapeutics Inc COMM 427746102 4,879 262,438 SH   OTR 2 262,438 0 0
Incyte Corp COMM 45337C102 2,526 29,736 SH   OTR 2 29,736 0 0
Intra-Cellular Therapies Inc COMM 46116X901 964 74,300 SH Call OTR 2 74,300 0 0
Intra-Cellular Therapies Inc COMM 46116X101 697 53,694 SH   OTR 2 53,694 0 0
Kadmon Holdings Inc COMM 48283N106 1,973 957,858 SH   OTR 2 957,858 0 0
Kala Pharmaceuticals Inc COMM 483119103 820 128,557 SH   OTR 2 128,557 0 0
MacroGenics Inc COMM 556099109 3,982 234,661 SH   OTR 2 234,661 0 0
MorphoSys AG COMM D55040105 3,943 41,061 SH   OTR 2 41,061 0 0
Neurocrine Biosciences Inc COMM 64125C109 5,626 66,638 SH   OTR 2 66,638 0 0
Novo Nordisk A/S ADR 670100205 7,062 138,371 SH   OTR 2 138,371 0 0
Orchard Therapeutics PLC ADR 68570P101 2,208 157,799 SH   OTR 2 157,799 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 863 227,022 SH   OTR 2 227,022 0 0
Otonomy Inc COMM 68906L105 1,611 585,775 SH   OTR 2 585,775 0 0
PTC Therapeutics Inc COMM 69366J200 7,053 156,727 SH   OTR 2 156,727 0 0
Reata Pharmaceuticals Inc COMM 75615P103 4,629 49,067 SH   OTR 2 49,067 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 965 103,679 SH   OTR 2 103,679 0 0
TG Therapeutics Inc COMM 88322Q108 4,652 537,747 SH   OTR 2 537,747 0 0
Uniqure NV COMM N90064101 1,665 21,300 SH Call OTR 2 21,300 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 3,990 21,756 SH   OTR 2 21,756 0 0
XBiotech Inc COMM 98400H102 1,075 141,839 SH   OTR 2 141,839 0 0
Zogenix Inc COMM 98978L904 1,013 21,200 SH Call OTR 2 21,200 0 0
Zymeworks Inc COMM 98985W102 1,769 80,417 SH   OTR 2 80,417 0 0