The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
BOOKING HOLDINGS INC COM 09857L108 10,519 5,611 SH   SOLE   5,611 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 14,289 532,166 SH   SOLE   532,166 0 0
COSTAR GROUP INC COM 22160N109 66,704 120,392 SH   SOLE   120,392 0 0
EDITAS MEDICINE INC COM 28106W103 4,593 185,668 SH   SOLE   185,668 0 0
ENTERA BIO LTD SHS M40527109 697 203,190 SH   SOLE   203,190 0 0
FACEBOOK INC CL A 30303M102 12,845 66,553 SH   SOLE   66,553 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 2,167 194,499 SH   SOLE   194,499 0 0
GOOSEHEAD INS INC COM CL A 38267D109 3,324 69,533 SH   SOLE   69,533 0 0
NANTKWEST INC COM 63016Q102 568 556,453 SH   SOLE   556,453 0 0
PLAYA HOTELS & RESORTS NV SHS N70544106 2,313 300,000 SH   SOLE   300,000 0 0
SABINE ROYALTY TR UNIT BEN INT 785688102 16,157 335,564 SH   SOLE   335,564 0 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 257 295,613 SH   SOLE   295,613 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 1,110 415,765 SH   SOLE   415,765 0 0
UROGEN PHARMA LTD COM M96088105 18,774 522,361 SH   SOLE   522,361 0 0
BEYOND MEAT INC CALL 08862E909 1,120 27,072 SH Call DFND   27,072 0 0
VANECK VECTORS ETF TR PUT 92189F156 192 80,000 SH Put DFND   80,000 0 0
UNITED STATES NATL GAS FUND CALL 912318900 3 4,000 SH Call DFND   4,000 0 0
UNITED STATES NATL GAS FUND PUT 912318950 1,248 534,400 SH Put DFND   534,400 0 0
SELECT SECTOR SPDR TR CALL 81369Y906 3,325 423,500 SH Call DFND   423,500 0 0
SELECT SECTOR SPDR TR PUT 81369Y956 2,149 289,800 SH Put DFND   289,800 0 0
SELECT SECTOR SPDR TR CALL 81369Y906 320 135,200 SH Call DFND   135,200 0 0
NANTHEALTH INC COM 630104107 43 81,870 SH   DFND   81,870 0 0
UROGEN PHARMA LTD COM M96088105 11,537 321,004 SH   DFND   321,004 0 0
SPDR GOLD TRUST GOLD SHS 78463V107 17,934 134,643 SH   DFND   134,643 0 0
ISHARES TR IBOXX HI YD ETF 464288513 6,479 74,648 SH   DFND   74,648 0 0
ISHARES TR IBOXX INV CP ETF 464287242 9,579 77,237 SH   DFND   77,237 0 0
ISHARES TR JPMORGAN USD EMG 464288281 7,932 70,289 SH   DFND   70,289 0 0
VANGUARD WHITEHALL FDS INC HIGH DIV YLD 921946406 2,830 32,391 SH   DFND   32,391 0 0
ISHARES TR 20 YR TR BD ETF 464287432 3,397 25,630 SH   DFND   25,630 0 0
CAMECO CORP COM 13321L108 4,013 374,039 SH   DFND   374,039 0 0
ISHARES TR NATIONAL MUN ETF 464288414 4,582 40,600 SH   DFND   40,600 0 0
UNITED STATES NATL GAS FUND UNIT PAR 912318300 103 5,200 SH   DFND   5,200 0 0