The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 1,673 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 1,643 | 40,000 | SH | DFND | 1 | 40,000 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 548 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 14,704 | 767,842 | SH | DFND | 1 | 767,842 | 0 | 0 | |
| ALLAKOS INC | COM | 01671P100 | 28,165 | 650,000 | SH | DFND | 1 | 650,000 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 9,695 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 39,494 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 75,161 | 2,966,108 | SH | DFND | 1 | 2,966,108 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 11,726 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 21,237 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 20,849 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 46,060 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 28,788 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 8,044 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 8,383 | 444,942 | SH | DFND | 1 | 444,942 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 2,840 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 11,270 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| AVROBIO INC | COM | 05455M100 | 4,472 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |
| AXONICS MODULATION TECH INC | COM | 05465P101 | 51,315 | 1,252,495 | SH | DFND | 1 | 1,252,495 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 67,875 | 1,550,000 | SH | DFND | 1 | 1,550,000 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 24,085 | 550,000 | SH | Call | DFND | 1 | 550,000 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 33,016 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 75,000 | 2,780,885 | SH | DFND | 1 | 2,780,885 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | *W EXP 08/20/201 | 15117F120 | 3 | 52,999 | SH | DFND | 1 | 52,999 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 21,997 | 2,365,280 | SH | DFND | 1 | 2,365,280 | 0 | 0 | |
| CONSTELLATION PHARMCETICLS I | COM | 210373106 | 15,616 | 1,271,685 | SH | DFND | 1 | 1,271,685 | 0 | 0 | |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 32,970 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 17,154 | 551,921 | SH | DFND | 1 | 551,921 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 12,190 | 1,150,000 | SH | DFND | 1 | 1,150,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 22,576 | 175,000 | SH | DFND | 1 | 175,000 | 0 | 0 | |
| GENFIT S A | ADS | 372279109 | 6,314 | 319,700 | SH | DFND | 1 | 319,700 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 14,265 | 643,129 | SH | DFND | 1 | 643,129 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 8,450 | 649,994 | SH | DFND | 1 | 649,994 | 0 | 0 | |
| HEALTH SCIENCES ACQUSTN CORP | UNIT 04/01/2024 | 42227C201 | 11,450 | 1,080,000 | SH | DFND | 1 | 1,080,000 | 0 | 0 | |
| HOMOLOGY MEDICINES INC | COM | 438083107 | 5,871 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| INFLARX NV | COM | N44821101 | 4,740 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| INSPIRE MED SYS INC | COM | 457730109 | 12,130 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ITERUM THERAPEUTICS PLC | SHS | G6333L101 | 2,727 | 396,385 | SH | DFND | 1 | 396,385 | 0 | 0 | |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 7,466 | 968,294 | SH | DFND | 1 | 968,294 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 27,566 | 1,400,000 | SH | DFND | 1 | 1,400,000 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 3,422 | 607,903 | SH | DFND | 1 | 607,903 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 113,300 | 1,100,000 | SH | DFND | 1 | 1,100,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 20,600 | 200,000 | SH | Call | DFND | 1 | 200,000 | 0 | 0 |
| MYOKARDIA INC | COM | 62857M105 | 25,070 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 14,232 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 4,222 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| NEXTCURE INC | COM | 65343E108 | 14,980 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 10,217 | 730,325 | SH | DFND | 1 | 730,325 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | COM NEW | 69012T206 | 32 | 15,752 | SH | DFND | 1 | 15,752 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 46 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 11,890 | 906,229 | SH | DFND | 1 | 906,229 | 0 | 0 | |
| PRECISION BIOSCIENCES, INC - SERIES B PREFERRED | COM | 74019P108 | 6,195 | 467,518 | SH | DFND | 1 | 467,518 | 0 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 45,201 | 1,361,898 | SH | DFND | 1 | 1,361,898 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 35,530 | 3,800,000 | SH | DFND | 1 | 3,800,000 | 0 | 0 | |
| RA PHARMACEUTICALS INC | COM | 74933V108 | 10,525 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 76,060 | 806,150 | SH | DFND | 1 | 806,150 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 31,119 | 2,074,595 | SH | DFND | 1 | 2,074,595 | 0 | 0 | |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 | 9,438 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 18,309 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 34,189 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 2,379 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 78,939 | 900,000 | SH | Put | DFND | 1 | 900,000 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 54,539 | 1,869,680 | SH | DFND | 1 | 1,869,680 | 0 | 0 | |
| TRICIDA INC | COM | 89610F101 | 46,483 | 1,177,975 | SH | DFND | 1 | 1,177,975 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 127,080 | 3,122,367 | SH | DFND | 1 | 3,122,367 | 0 | 0 | |
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 20,483 | 706,064 | SH | DFND | 1 | 706,064 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 46,890 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 7,815 | 100,000 | SH | Call | DFND | 1 | 100,000 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 15,587 | 85,000 | SH | DFND | 1 | 85,000 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 13,356 | 890,387 | SH | DFND | 1 | 890,387 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 22,870 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ZAI LAB LTD | ADR | 98887Q104 | 10,461 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |