The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 6,997 83,198 SH   SOLE   83,198 0 0
ABEONA THERAPEUTICS COM 00289Y107 61 12,681 SH   SOLE   12,681 0 0
ABIOMED INC COM 003654100 424 1,626 SH   SOLE   1,626 0 0
ACCELERON PHARMA COM 00434H108 11,067 269,396 SH   SOLE   131,299 0 138,097
ACELRX PHARMACEUTICALS COM 00444T100 187 73,778 SH   SOLE   73,778 0 0
AERIE PHARMACEUTICALS COM 00771V108 28,251 956,036 SH   SOLE   517,252 0 438,784
AEGLEA BIOTHERAPEUTICS COM 00773J103 89 12,954 SH   SOLE   12,954 0 0
AGIOS PHARMACEUTICALS COM 00847X104 3,990 80,000 SH   SOLE   80,000 0 0
ALBIREO PHARMA INC COM 01345P106 7,834 242,978 SH   SOLE   124,789 0 118,189
ALEXION PHARM INC COM 015351109 9,588 73,199 SH   SOLE   73,199 0 0
ALNYLAM PHARMACEUTICALS COM 02043Q107 29,216 402,641 SH   SOLE   209,441 0 193,200
AMICUS THERAPEUTICS COM 03152W109 41,491 3,324,623 SH   SOLE   1,490,366 0 1,834,257
ANTARES PHARMA INC COM 036642106 156 47,280 SH   SOLE   47,280 0 0
APELLIS PHARMACEUTICALS COM 03753U106 37,756 1,489,957 SH   SOLE   1,171,994 0 317,963
ARRAY BIOPHARMA INC COM 04269X105 36,826 794,868 SH   SOLE   330,510 0 464,358
ASSEMBLY BIOSCIENCES COM 045396108 11,435 847,696 SH   SOLE   633,596 0 214,100
ATRICURE INC COM 04963C209 11,555 387,224 SH   SOLE   105,937 0 281,287
BECTON DICKINSON COM 075887109 760 3,015 SH   SOLE   3,015 0 0
BEIGENE LIMITED SPONSORED ADR 07725L102 1,392 11,227 SH   SOLE   11,227 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,113 153,101 SH   SOLE   153,101 0 0
BIOLINERX LTD SPONSORED ADS 09071M106 65 178,297 SH   SOLE   178,297 0 0
BLUEPRINT MEDICINES COM 09627Y109 1,036 10,984 SH   SOLE   10,984 0 0
BOSTON SCIENTIFIC COM 101137107 9,738 226,576 SH   SOLE   226,576 0 0
BRISTOL MYERS SQUIBB COM 110122108 9,737 214,697 SH   SOLE   214,697 0 0
CIGNA CORP COM 125523100 7,454 47,313 SH   SOLE   47,313 0 0
CHANGE HEALTHCARE IN COM 15912K100 6,578 450,550 SH   SOLE   187,342 0 263,208
CHEMOCENTRYX INC COM 16383L106 166 17,811 SH   SOLE   17,811 0 0
CLEARSIDE BIOMEDICAL COM 185063104 25 25,959 SH   SOLE   25,959 0 0
COLLEGIUM PHARMACEUTICAL COM 19459J104 15,449 1,174,847 SH   SOLE   673,691 0 501,156
CORVUS PHARMACEUTICALS COM 221015100 47 12,594 SH   SOLE   12,594 0 0
CYTOMX THERAPEUTICS COM 23284F105 113 10,058 SH   SOLE   10,058 0 0
DR REDDYS LABS LTD ADR 256135203 1,476 39,397 SH   SOLE   39,397 0 0
EVELO BIOSCIENCES COM 299734103 6,011 669,382 SH   SOLE   276,029 0 393,353
EVOLENT HEALTH INC COM 30050B101 10,799 1,358,352 SH   SOLE   567,100 0 791,252
EXACT SCIENCES CORP COM 30063P105 4,533 38,400 SH   SOLE   0 0 38,400
FIBROGEN INC COM 31572Q808 13,674 302,660 SH   SOLE   136,400 0 166,260
FORTY SEVEN INC COM 34983P104 6,961 656,651 SH   SOLE   412,801 0 243,850
GILEAD SCIENCES INC COM 375558103 26,892 398,040 SH   SOLE   398,040 0 0
GLOBAL BLOOD THERAPEUTICS COM 37890U108 11,900 226,241 SH   SOLE   123,488 0 102,753
GLYCOMIMETICS INC COM 38000Q102 6,589 552,806 SH   SOLE   300,699 0 252,107
HMS HOLDINGS CORP COM 40425J101 10,082 311,278 SH   SOLE   49,378 0 261,900
HILL-ROM HLDS INC COM 431475102 16,614 158,799 SH   SOLE   15,800 0 142,999
HUTCHISON CHINA ME SPONSORED ADR 44842L103 696 31,628 SH   SOLE   31,628 0 0
IRHYTHM TECHNOLOGIES COM 450056106 6,848 86,600 SH   SOLE   0 0 86,600
IMMUNOMEDICS INC COM 452907108 5,810 418,900 SH   SOLE   67,700 0 351,200
INSPIRE MED SYS INC COM 457730109 7,333 120,900 SH   SOLE   26,000 0 94,900
INSULET CORP COM 45784P101 4,317 36,160 SH   SOLE   9,251 0 26,909
KALVISTA PHARMACEUTICALS COM 483497103 389 17,551 SH   SOLE   17,551 0 0
KURA ONCOLOGY INC COM 50127T109 232 11,800 SH   SOLE   11,800 0 0
LA JOLLA PHARMACEUTICAL COM 503459604 15,329 1,657,171 SH   SOLE   982,227 0 674,944
LILLY ELI & CO COM 532457108 11,817 106,665 SH   SOLE   106,665 0 0
MEI PHARMA INC COM 55279B202 111 44,539 SH   SOLE   44,539 0 0
MARINUS PHARMACEUTICALS COM 56854Q101 70 16,800 SH   SOLE   16,800 0 0
MERCK & CO INC COM 58933Y105 13,986 166,800 SH   SOLE   166,800 0 0
MOLECULAR TEMPLATES COM 608550109 2,923 350,000 SH   SOLE   350,000 0 0
MYOKARDIA INC COM 62857M105 203 4,051 SH   SOLE   4,051 0 0
NOVARTIS AG SPONSORED ADR 66987V109 16,677 182,646 SH   SOLE   182,646 0 0
PTC THERAPEUTICS I COM 69366J200 20,279 450,638 SH   SOLE   229,781 0 220,857
PFIZER INC COM 717081103 15,722 362,927 SH   SOLE   362,927 0 0
PHASEBIO PHARMACEUTICALS COM 717224109 2,309 176,000 SH   SOLE   176,000 0 0
PORTOLA PHARMACEUTICALS COM 737010108 19,576 721,556 SH   SOLE   323,114 0 398,442
PROTAGONIST THERAPEUTICS COM 74366E102 138 11,400 SH   SOLE   11,400 0 0
RA PHARMACEUTICALS COM 74933V108 20,018 665,713 SH   SOLE   346,190 0 319,523
R1 RCM INC COM 749397105 13,572 1,078,872 SH   SOLE   308,072 0 770,800
REVANCE THERAPEUTICS COM 761330109 146 11,234 SH   SOLE   11,234 0 0
SAGE THERAPEUTICS COM 78667J108 4,467 24,400 SH   SOLE   24,400 0 0
SAREPTA THERAPEUTICS COM 803607100 17,793 117,097 SH   SOLE   80,999 0 36,098
SAVARA INC COM 805111101 1,756 741,100 SH   SOLE   474,692 0 266,408
SHOCKWAVE MEDICAL COM 82489T104 48,516 849,811 SH   SOLE   849,811 0 0
SIERRA ONCOLOGY INC COM 82640U107 23 41,076 SH   SOLE   41,076 0 0
SPRING BK PHARMACEUTICALS COM 849431101 1,021 276,656 SH   SOLE   276,656 0 0
STEMLINE THERAPEUTICS COM 85858C107 10,206 666,158 SH   SOLE   360,958 0 305,200
TANDEM DIABETES CARE COM 875372203 20,638 319,866 SH   SOLE   80,766 0 239,100
TELADOC HEALTH COM 87918A105 34,079 513,166 SH   SOLE   134,510 0 378,656
TETRAPHASE PHARMACEUTICALS COM 88165N105 19 39,821 SH   SOLE   39,821 0 0
THERMO FISHER SCIENTIFIC COM 883556102 1,013 3,450 SH   SOLE   3,450 0 0
TOCAGEN INC COM 888846102 4,476 669,997 SH   SOLE   371,650 0 298,347
UNUM THERAPEUTICS COM 903214104 4,159 1,587,437 SH   SOLE   862,009 0 725,428
VERTEX PHARMACEUTICALS COM 92532F100 6,926 37,771 SH   SOLE   37,771 0 0
VIEWRAY INC COM 92672L107 9,438 1,071,265 SH   SOLE   326,770 0 744,495
VOCERA COMMUNICATIONS COM 92857F107 12,181 381,604 SH   SOLE   136,722 0 244,882
ZAI LAB LTD ADR 98887Q104 439 12,589 SH   SOLE   12,589 0 0
ZIMMER BIOMET HLDS COM 98956P102 5,957 50,598 SH   SOLE   50,598 0 0
ALLERGAN PLC SHS G0177J108 13,110 78,300 SH   SOLE   78,300 0 0
MEDTRONIC PLC SHS G5960L103 7,485 76,851 SH   SOLE   76,851 0 0
MEIRAGTX HLDINGS PLC COM G59665102 6,072 225,906 SH   SOLE   225,906 0 0
NABRIVA THERAPEUTICS SHS G63637105 93 38,255 SH   SOLE   38,255 0 0
OBSEVA SA COM H5861P103 7,274 643,151 SH   SOLE   643,151 0 0
INTEC PHARMA LTD JER SHS M53644106 3,815 879,000 SH   SOLE   879,000 0 0
UROGEN PHARMA LTD COM M96088105 2,338 65,063 SH   SOLE   65,063 0 0
UNIQURE N.V. SHS N90064101 1,133 14,500 SH   SOLE   14,500 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 15,243 511,173 SH   SOLE   203,501 0 307,672