The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 2,029 524,300 SH   SOLE 524,300 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 1,621 604,884 SH   SOLE 604,884 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 6,071 205,440 SH   SOLE 205,440 0 0
AILERON THERAPEUTICS INC COM 00887A105 72 99,502 SH   SOLE 99,502 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 4,020 830,538 SH   SOLE 830,538 0 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 232 250,000 PRN   SOLE 250,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 7,486 636,013 SH   SOLE 636,013 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 300 50,000 SH   SOLE 50,000 0 0
ALECTOR INC COM 014442107 440 23,166 SH   SOLE 23,166 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,361 359,190 SH   SOLE 359,190 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 23 2,400 SH   SOLE 2,400 0 0
ARDELYX INC COM 039697107 1,834 681,759 SH   SOLE 681,759 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 5,508 93,942 SH   SOLE 93,942 0 0
ARGENX SE SPONSORED ADR 04016X101 4,495 31,750 SH   SOLE 31,750 0 0
ARQULE INC COM 04269E107 5,480 497,762 SH   SOLE 497,762 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 6,838 59,380 SH   SOLE 59,380 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 682 50,573 SH   SOLE 50,573 0 0
ATRICURE INC COM 04963C209 9,511 318,729 SH   SOLE 318,729 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,610 100,000 SH   SOLE 100,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 51 30,000 SH   SOLE 30,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,557 410,888 SH   SOLE 410,888 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 4,160 95,000 SH   SOLE 95,000 0 0
BIOTELEMETRY INC COM 090672106 2,181 45,300 SH   SOLE 45,300 0 0
BIOTIME INC COM 09066L105 105 95,000 SH   SOLE 95,000 0 0
BLUEBIRD BIO INC COM 09609G100 3,244 25,500 SH   SOLE 25,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 11,623 123,218 SH   SOLE 123,218 0 0
CARA THERAPEUTICS INC COM 140755109 4,408 205,011 SH   SOLE 205,011 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 2,198 51,200 SH   SOLE 51,200 0 0
CIDARA THERAPEUTICS INC COM 171757107 357 212,766 SH   SOLE 212,766 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 2,060 297,300 SH   SOLE 297,300 0 0
CORTEXYME INC COM 22053A107 2,780 65,400 SH   SOLE 65,400 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,506 349,996 SH   SOLE 349,996 0 0
CYTOKINETICS INC COM NEW 23282W605 5,368 477,196 SH   SOLE 477,196 0 0
DERMIRA INC COM 24983L104 994 104,000 SH   SOLE 104,000 0 0
DEXCOM INC COM 252131107 5,445 36,338 SH   SOLE 36,338 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 399 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,863 118,314 SH   SOLE 118,314 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 3,739 375,000 SH   SOLE 375,000 0 0
EPIZYME INC COM 29428V104 2,178 173,536 SH   SOLE 173,536 0 0
FATE THERAPEUTICS INC COM 31189P102 1,219 60,031 SH   SOLE 60,031 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,923 808,000 SH   SOLE 808,000 0 0
GALAPAGOS NV SPON ADR 36315X101 6,770 52,509 SH   SOLE 52,509 0 0
GAMIDA CELL LTD SHS M47364100 1,397 275,000 SH   SOLE 275,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 2,879 734,422 SH   SOLE 734,422 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 557 50,000 SH   SOLE 50,000 0 0
INOGEN INC COM 45780L104 1,535 23,000 SH   SOLE 23,000 0 0
INSMED INC COM PAR $.01 457669307 768 30,000 SH   SOLE 30,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 1,805 415,989 SH   SOLE 415,989 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 6,699 61,400 SH   SOLE 61,400 0 0
JOHNSON AND JOHNSON COM 478160104 1,309 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 1,826 886,177 SH   SOLE 886,177 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 548 24,725 SH   SOLE 24,725 0 0
KARUNA THERAPEUTICS INC COM 48576A100 200 10,000 SH   SOLE 10,000 0 0
KURA ONCOLOGY INC COM 50127T109 930 47,242 SH   SOLE 47,242 0 0
LUMINEX CORP COM 55027E102 4,006 194,091 SH   SOLE 194,091 0 0
MACROGENICS INC COM 556099109 849 50,000 SH   SOLE 50,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 692 6,600 SH   SOLE 6,600 0 0
MASIMO CORPORATION COM 574795100 446 3,000 SH   SOLE 3,000 0 0
MENLO THERAPEUTICS INC COM 586858102 3,594 600,030 SH   SOLE 600,030 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,115 275,236 SH   SOLE 275,236 0 0
MORPHIC HOLDING INC COM 61775R105 1,189 60,000 SH   SOLE 60,000 0 0
NATUS MEDICAL INC COM 639050103 1,102 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,455 64,608 SH   SOLE 64,608 0 0
NEVRO CORP COM 64157F103 1,699 26,210 SH   SOLE 26,210 0 0
NEXTCURE INC COM 65343E108 1,440 96,100 SH   SOLE 96,100 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 92 6,265 SH   SOLE 6,265 0 0
OBSEVA SA COM H5861P103 564 49,848 SH   SOLE 49,848 0 0
ORAMED PHARMACEUTICALS INC COM NEW 68403P203 57 16,000 SH   SOLE 16,000 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,624 200,013 SH   SOLE 200,013 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 990 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 2,380 261,521 SH   SOLE 261,521 0 0
RADIUS HEALTH INC COM NEW 750469207 536 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,624 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 359 137,600 SH   SOLE 137,600 0 0
SAGE THERAPEUTICS INC COM 78667J108 22,668 123,806 SH   SOLE 123,806 0 0
SCYNEXIS INC COM 811292101 1,668 1,272,927 SH   SOLE 1,272,927 0 0
SOL GEL TECHNOLOGIES LTD SHS M8694L103 319 35,000 SH   SOLE 35,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 806 70,000 SH   SOLE 70,000 0 0
STEREOTAXIS INC COM 85916J409 39,673 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 358 31,494 SH   SOLE 31,494 0 0
TRANSLATE BIO INC COM 89374L104 2,252 178,306 SH   SOLE 178,306 0 0
UROGEN PHARMA LTD COM M96088105 539 15,000 SH   SOLE 15,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,736 209,200 SH   SOLE 209,200 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 5,676 217,554 SH   SOLE 217,554 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,260 330,667 SH   SOLE 330,667 0 0
ZAFGEN INC COM 98885E103 340 285,500 SH   SOLE 285,500 0 0
ZOGENIX INC COM NEW 98978L204 6,726 140,764 SH   SOLE 140,764 0 0